Theodore G Liou, Natalia Argel, Fadi Asfour, Perry S Brown, Barbara A Chatfield, David R Cox, Cori L Daines, Dixie Durham, Jessica A Francis, Barbara Glover, My Helms, Theresa Heynekamp, John R Hoidal, Judy L Jensen, Christiana Kartsonaki, Ruth Keogh, Carol M Kopecky, Noah Lechtzin, Yanping Li, Jerimiah Lysinger, Osmara Molina, Craig Nakamura, Kristyn A Packer, Robert Paine, Katie R Poch, Alexandra L Quittner, Peggy Radford, Abby J Redway, Scott D Sagel, Rhonda D Szczesniak, Shawna Sprandel, Jennifer L Taylor-Cousar, Jane B Vroom, Ryan Yoshikawa, John P Clancy, J Stuart Elborn, Kenneth N Olivier, Frederick R Adler
Airway inflammation underlies cystic fibrosis (CF) pulmonary exacerbations. In a prospective multicenter study of randomly selected, clinically stable adolescents and adults, we assessed relationships between 24 inflammation-associated molecules and the future occurrence of CF pulmonary exacerbation using proportional hazards models. We explored relationships for potential confounding or mediation by clinical factors and assessed sensitivities to treatments including CF transmembrane regulator (CFTR) protein synthesis modulators...
March 15, 2024: IScience