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Liver ablation

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https://www.readbyqxmd.com/read/28813662/a-liver-capsular-network-of-monocyte-derived-macrophages-restricts-hepatic-dissemination-of-intraperitoneal-bacteria-by-neutrophil-recruitment
#1
Frederic Sierro, Maximilien Evrard, Simone Rizzetto, Michelle Melino, Andrew J Mitchell, Manuela Florido, Lynette Beattie, Shaun B Walters, Szun Szun Tay, Bo Lu, Lauren E Holz, Ben Roediger, Yik Chun Wong, Alessandra Warren, William Ritchie, Claire McGuffog, Wolfgang Weninger, David G Le Couteur, Florent Ginhoux, Warwick J Britton, William R Heath, Bernadette M Saunders, Geoffrey W McCaughan, Fabio Luciani, Kelli P A MacDonald, Lai Guan Ng, David G Bowen, Patrick Bertolino
The liver is positioned at the interface between two routes traversed by pathogens in disseminating infection. Whereas blood-borne pathogens are efficiently cleared in hepatic sinusoids by Kupffer cells (KCs), it is unknown how the liver prevents dissemination of peritoneal pathogens accessing its outer membrane. We report here that the hepatic capsule harbors a contiguous cellular network of liver-resident macrophages phenotypically distinct from KCs. These liver capsular macrophages (LCMs) were replenished in the steady state from blood monocytes, unlike KCs that are embryonically derived and self-renewing...
August 15, 2017: Immunity
https://www.readbyqxmd.com/read/28809734/wait-time-for-curative-intent-radio-frequency-ablation-is-associated-with-increased-mortality-in-patients-with-early-stage-hepatocellular-carcinoma
#2
Mayur Brahmania, Osman Ahmed, Melissa Kelley, David Wong, Matthew Kowgier, Korosh Khalili, Rob Beecroft, Eberhard L Renner, Hemant Shah, Jordan Feld, Harry L A Janssen, Morris Sherman
INTRODUCTION: Radiofrequency ablation (RFA) is a recommended curative intent treatment option for patients with early stage hepatocellular carcinoma (HCC). We investigated if wait times for RFA were associated with residual tumor, tumor recurrence, need for liver transplantation, or death. MATERIAL AND METHODS: We conducted a retrospective study of patients diagnosed with HCC between January 2010 and December 2013 presenting to University Health Network (UHN) in Toronto, Canada...
August 8, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28809681/a-prototype-therapy-system-for-transcutaneous-application-of-boiling-histotripsy
#3
Adam D Maxwell, Petr V Yuldashev, Wayne Kreider, Tatiana D Khokhlova, George R Schade, Timothy L Hall, Oleg A Sapozhnikov, Michael R Bailey, Vera A Khokhlova
Boiling histotripsy is a method of focused ultrasound surgery that noninvasively applies millisecond-length pulses with high-amplitude shock fronts to generate liquefied lesions in tissue. Such a technique requires unique outputs compared to a focused ultrasound thermal therapy apparatus, particularly to achieve high in situ pressure levels through intervening tissue. This article describes the design and characterization of a system capable of producing the necessary pressure to transcutaneously administer boiling histotripsy therapy through clinically relevant overlying tissue paths using pulses with duration up to 10 ms...
August 14, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28807570/albumin-bilirubin-grade-predicts-the-outcomes-of-liver-resection-versus-radiofrequency-ablation-for-very-early-early-stage-of-hepatocellular-carcinoma
#4
Charing Ching-Ning Chong, Anthony Wing-Hung Chan, John Wong, Cheuk-Man Chu, Stephen Lam Chan, Kit-Fai Lee, Simon Chun-Ho Yu, Ka-Fai To, Philip Johnson, Paul Bo-San Lai
BACKGROUND AND PURPOSE: Whether liver resection or ablation should be the first-line treatment for very early/early hepatocellular carcinoma (HCC) in patients who are candidates for both remains controversial. The aim of this study was to determine if the newly-developed Albumin-Bilirubin (ALBI) grade might help in treatment selections and to evaluate the survival of patients treated with liver resection and radiofrequency ablation (RFA). METHODS: Patients with BCLC stage 0/A HCC who were treated with curative liver resection and RFA from 2003 to 2013 were included...
August 11, 2017: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
https://www.readbyqxmd.com/read/28807252/role-of-hepatic-trisectionectomy-in-advanced-hepatocellular-carcinoma
#5
J S Tsang, K S H Chok, C M Lo
BACKGROUND: Advanced hepatocellular carcinoma (HCC) with underlying cirrhosis poses a major operative challenge. Patients have a dismal prognosis without curative resection. The role of hepatic trisectionectomy in these patients is not established. The aim of this study was to analyze and compare the perioperative outcome and prognosis of patients undergoing trisectionectomy with hepatic resection of a lesser extent. METHODS: From 2000 to 2014, 48 patients underwent hepatic trisectionectomy for HCC with background cirrhosis or chronic hepatitis (Group A)...
September 2017: Surgical Oncology
https://www.readbyqxmd.com/read/28807242/efficacy-and-safety-of-combination-therapy-of-chemoembolization-and-radiofrequency-ablation-with-different-time-intervals-for-hepatocellular-carcinoma-patients
#6
Yue-Min Feng, Xing Wang, Le Wang, Xiao-Wen Ma, Hao Wu, Hao-Ran Bu, Xiao-Yu Xie, Jian-Ni Qi, Qiang Zhu
BACKGROUND AND OBJECTIVES: Combination of transcatheter arterial chemoembolization (TACE) and radiofrequency ablation (RFA) has become an effective alternative therapy for hepatocellular carcinoma (HCC). In clinical practice, the choice of time interval between TACE and RFA is a key point for curative effect, but optimal time interval is uncertain in guidelines. We aim to explore the optimal time interval for HCC patients of Child-Pugh classification A or B. METHODS: Two hundred and thirty-three HCC patients of Child A or B who had undergone TACE and RFA were enrolled and divided into seven groups according to different time intervals (1-7weeks)...
September 2017: Surgical Oncology
https://www.readbyqxmd.com/read/28803547/cryoablation-of-cardiophrenic-angle-lymph-node-metastases-a-case-report
#7
Xiaomei Luo, Weibing He, Xinan Long, Gang Fang, Zhonghai Li, Rongrong Li, Kecheng Xu, Lizhi Niu
BACKGROUND: Cardiophrenic angle lymph node metastases are relatively rare. Surgical resection is the main treatment for cardiophrenic angle lymph node metastasis, but it is not always possible. CASE PRESENTATION: Here, we report our initial experience with cryoablation of a cardiophrenic angle lymph node metastasis from liver cancer. As the cardiophrenic angle lymph node metastasis was located close to the heart, about 200 mL of 0.9% saline was injected into the pericardium to separate the heart from the target area...
August 14, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28799842/midterm-safety-and-efficacy-of-irreversible-electroporation-of-malignant-liver-tumors-located-close-to-major-portal-or-hepatic-veins
#8
Martina Distelmaier, Alexandra Barabasch, Philipp Heil, Nils A Kraemer, Peter Isfort, Sebastian Keil, Christiane K Kuhl, Philipp Bruners
Purpose To investigate the efficacy and safety of irreversible electroporation (IRE) in the treatment of hepatic tumors not suitable for thermal ablation (radiofrequency ablation [RFA] or microwave ablation). Materials and Methods This was an institutional review board-approved prospective study in 29 patients (15 men, 14 women; mean age, 63 years ± 12 [standard deviation]) with 43 primary (n = 8) or secondary (n = 35) malignant liver tumors who underwent computed tomography (CT)-guided IRE. All target tumors were located immediately adjacent to major hepatic veins, portal veins, or both; thus, they were not considered suitable for RFA or microwave ablation...
August 11, 2017: Radiology
https://www.readbyqxmd.com/read/28797220/a-review-of-ultrasound-tissue-characterization-with-mean-scatterer-spacing
#9
Zhuhuang Zhou, Weiwei Wu, Shuicai Wu, Kebin Jia, Po-Hsiang Tsui
Tissues exhibiting quasi-periodic structures can be modeled as a collection of diffuse scatterers and coherent scatterers. The mean scatterer spacing (MSS) of coherent and quasi-periodic components is directly related to tissue microstructure and has become an important quantitative ultrasound (QUS) parameter in the characterization of quasi-periodic tissues. In this paper, a review of the literature on the development of MSS as a QUS parameter was conducted. First, a unified theoretical background of MSS estimates was provided...
September 2017: Ultrasonic Imaging
https://www.readbyqxmd.com/read/28794002/klf4-regulation-of-ch25h-and-lxr-mitigates-atherosclerosis-susceptibility
#10
Zhao Li, Marcy Martin, Jin Zhang, Hsi-Yuan Huang, Liang Bai, Jiao Zhang, Jian Kang, Ming He, Jie Li, Mano R Maurya, Shakti Gupta, Guangjin Zhou, Panjamaporn Sangwung, Yong-Jiang Xu, Ting Lei, Hsien-Da Huang, Mohit Jain, Mukesh K Jain, Shankar Subramaniam, John Y-J Shyy
Background -Atherosclerosis is a multifaceted inflammatory disease involving cells in the vascular wall [e.g., endothelial cells (ECs)] as well as circulating and resident immunogenic cells (e.g., monocytes/macrophages). Acting as a ligand for liver X receptor (LXR), but an inhibitor of sterol regulatory element binding protein 2 (SREBP2), 25-hydroxycholesterol (25-HC) and its catalyzing enzyme cholesterol-25-hydroxylase (Ch25h) are important in regulating cellular inflammatory status and cholesterol biosynthesis in both ECs and monocytes/macrophages...
August 9, 2017: Circulation
https://www.readbyqxmd.com/read/28791798/cost-effectiveness-analysis-of-potentially-curative-and-combination-treatments-for-hepatocellular-carcinoma-with-person-level-data-in-a-canadian-setting
#11
Hla-Hla Thein, Wanrudee Isaranuwatchai, Yao Qiao, Kenny Wong, Gonzalo Sapisochin, Kelvin K W Chan, Eric M Yoshida, Craig C Earle
Patients with early-stage hepatocellular carcinoma (HCC) are potential candidates for curative treatments such as radiofrequency ablation (RFA), surgical resection (SR), or liver transplantation (LT), which have demonstrated a significant survival benefit. We aimed to estimate the cost-effectiveness of curative and combination treatment strategies among patients diagnosed with HCC during 2002-2010. This study used Ontario Cancer Registry-linked administrative data to estimate effectiveness and costs (2013 USD) of the treatment strategies from the healthcare payer's perspective...
August 8, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28789977/ablation-of-systemic-sirt1-activity-promotes-nonalcoholic-fatty-liver-disease-by-affecting-liver-mesenteric-adipose-tissue-fatty-acid-mobilization
#12
Junrui Cheng, Chun Liu, Kangquan Hu, Andrew Greenberg, Dayong Wu, Lynne M Ausman, Michael W McBurney, Xiang-Dong Wang
Sirtuin 1 (SIRT1) has been reported to protect against nonalcoholic fatty liver disease (NAFLD) development. The mechanism of how SIRT1 deacetylase activity affects NAFLD has not been well investigated. The current investigation addressed the causal effect of systemic SIRT1 activity on NAFLD development and the underlying mechanism involved in both liver and mesenteric adipose tissue (MAT). Both SIRT1 homozygous mice ablated the catalytic activity (sirt1(Y/Y)) and their corresponding wild type littermates (WT) were fed a high fat diet (HFD, 60% calories from fat) for 34weeks...
August 5, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28782810/establishment-of-estrogen-receptor-1-esr1-knockout-medaka-esr1-is-dispensable-for-sexual-development-and-reproduction-in-medaka-oryzias-latipes
#13
Saki Tohyama, Yukiko Ogino, Anke Lange, Taijun Myosho, Tohru Kobayashi, Yu Hirano, Gen Yamada, Tomomi Sato, Norihisa Tatarazako, Charles R Tyler, Taisen Iguchi, Shinichi Miyagawa
Estrogens play fundamental roles in regulating reproductive activities and they act through estrogen receptor (ESR) in all vertebrates. Most vertebrates have two ESR subtypes (ESR1 and ESR2), whereas teleost fish have at least three (Esr1, Esr2a and Esr2b). Intricate functionalization has been suggested among the Esr subtypes, but to date, distinct roles of Esr have been characterized in only a limited number of species. Study of loss-of-function in animal models is a powerful tool for application to understanding vertebrate reproductive biology...
August 7, 2017: Development, Growth & Differentiation
https://www.readbyqxmd.com/read/28782504/cryoelectrolysis-an-acute-case-study-in-the-pig-liver
#14
Franco Lugnani, Enric Gunther, Pedro Torrecillas, Carlos Galacho, Adolfo Jiménez Garrido, Paul Mikus, Nina Klein, Michael K Stehling, Matteo Macchioro, Liel Rubinsky, Narayan Raju, Boris Rubinsky
We report results from an acute, single case study in the pig liver on the effects of a tissue ablation protocol (we named cryoelectrolysis) in which 10 min of cryosurgery, with a commercial cryosurgical probe, are delivered after 10 min of electrolysis generated by a current of about 60 mA. The histological appearance of tissue treated with cryoelectrolysis is compared with the appearance of tissue treated with 10 min of cryosurgery alone and with 10 min of electrolysis alone. Histology done after 3 h survival shows that the mixed rim of live and dead cells found around the ablated lesion in both cryosurgery and electrolytic ablation is replaced by a sharp margin between life and dead cells in cryoelectrolysis...
August 3, 2017: Cryobiology
https://www.readbyqxmd.com/read/28781171/first-line-selective-internal-radiotherapy-plus-chemotherapy-versus-chemotherapy-alone-in-patients-with-liver-metastases-from-colorectal-cancer-foxfire-sirflox-and-foxfire-global-a-combined-analysis-of-three-multicentre-randomised-phase-3-trials
#15
Harpreet S Wasan, Peter Gibbs, Navesh K Sharma, Julien Taieb, Volker Heinemann, Jens Ricke, Marc Peeters, Michael Findlay, Andrew Weaver, Jamie Mills, Charles Wilson, Richard Adams, Anne Francis, Joanna Moschandreas, Pradeep S Virdee, Peter Dutton, Sharon Love, Val Gebski, Alastair Gray, Guy van Hazel, Ricky A Sharma
BACKGROUND: Data suggest selective internal radiotherapy (SIRT) in third-line or subsequent therapy for metastatic colorectal cancer has clinical benefit in patients with colorectal liver metastases with liver-dominant disease after chemotherapy. The FOXFIRE, SIRFLOX, and FOXFIRE-Global randomised studies evaluated the efficacy of combining first-line chemotherapy with SIRT using yttrium-90 resin microspheres in patients with metastatic colorectal cancer with liver metastases. The studies were designed for combined analysis of overall survival...
August 3, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28777492/gankyrin-induces-stat3-activation-in-tumour-microenvironment-and-sorafenib-resistance-in-hepatocellular-carcinoma
#16
Toshiharu Sakurai, Norihisa Yada, Satoru Hagiwara, Tadaaki Arizumi, Kosuke Minaga, Ken Kamata, Mamoru Takenaka, Yasunori Minami, Tomohiro Watanabe, Naoshi Nishida, Masatoshi Kudo
Most hepatocellular carcinomas (HCCs) develop as a result of chronic liver inflammation. We have shown that the oncoprotein gankyrin is critical for inflammation-induced tumourigenesis in the colon. Although the in vitro function of gankyrin is well known, its role in vivo remains to be elucidated. We investigated the effect of gankyrin in tumour microenvironment of mice with liver parenchymal cell-specific gankyrin ablation (Alb-Cre;gankyrin(f/f) ) and gankyrin deletion both in liver parenchymal and non-parenchymal cells (Mx1-Cre;gankyrin(f/f) )...
August 4, 2017: Cancer Science
https://www.readbyqxmd.com/read/28777429/changes-of-reduced-glutathione-and-glutathione-s-transferase-levels-in-colorectal-cancer-patients-undergoing-treatment
#17
Edita Baltruskeviciene, Birutė Kazbariene, Eduardas Aleknavicius, Aurelija Krikstaponiene, Lina Venceviciene, Kestutis Suziedelis, Eugenijus Stratilatovas, Janina Didziapetriene
PURPOSE: The available data concerning reduced glutathione (GSH) and glutathione S-transferase (GST) levels in colorectal cancer patients during the treatment process are contradictory and insufficient. METHODS: Forty patients with metastatic colorectal cancer receiving FOLFOX4 chemotherapy with or without bevacizumab and 40 healthy volunteers were included in the study. Blood samples were taken before treatment, after 2 months and at the end of treatment in the patient group and once in the healthy volunteer group...
July 25, 2017: Tumori
https://www.readbyqxmd.com/read/28775376/altered-circadian-feeding-behavior-and-improvement-of-metabolic-syndrome-in-obese-tac1-deficient-mice
#18
C A Maguire, S León, R S Carroll, U B Kaiser, V M Navarro
BACKGROUND: Metabolic function is regulated by the interplay of central and peripheral factors that ultimately regulate food intake and energy expenditure. The tachykinin substance P (SP) has been identified as a novel regulator of energy balance, however, the mechanisms underlying this effect are ill-defined and conflicting data regarding the role of SP on food intake have been reported by different groups. OBJECTIVE: To further characterize the metabolic role of the Tac1 gene products (SP and neurokinin A (NKA)) in mice through a series of genetic, metabolic and behavioral studies in Tac1 deficient mice...
August 4, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28774878/the-actin-binding-protein-profilin-2-is-a-novel-regulator-of-iron-homeostasis
#19
Sara Luscieti, Bruno Galy, Lucia Gutierrez, Michael Reinke, Jorge Couso, Maya Shvartsman, Antonio Di Pascale, Walter Witke, Matthias W Hentze, Pietro Pilo Boyl, Mayka Sanchez
Cellular iron homeostasis is controlled by the iron regulatory proteins (IRPs) 1 and 2 that bind cis-regulatory iron-responsive elements (IRE) on target mRNAs. We identified the profilin2 (Pfn2) mRNA, which encodes an actin binding protein involved in endocytosis and neurotransmitters release, as a novel IRP-interacting transcript and studied its role in iron metabolism. Combination of EMSA experiments and bioinformatic analyses led to the identification of an atypical and conserved IRE in the 3' untranslated region of Pfn2 mRNA...
August 3, 2017: Blood
https://www.readbyqxmd.com/read/28774210/evaluation-of-microwave-ablation-of-liver-malignancy-with-enabled-constant-spatial-energy-control-to-achieve-a-predictable-spherical-ablation-zone
#20
Thomas J Vogl, Lajos M Basten, Nour-Eldin A Nour-Eldin, Benjamin Kaltenbach, Boris Bodelle, Julian L Wichmann, Hanns Ackermann, Nagy N N Naguib
OBJECTIVES: To evaluate the clinical performance of a new microwave ablation (MWA) system with enabled constant spatial energy control (ECSEC) to achieve spherical ablation zones in the treatment of liver malignancies. MATERIALS AND METHODS: In this retrospective study, 56 hepatic tumours in 48 patients (23 men, 25 women; mean age: 59.6 years) were treated using a new high-frequency MWA-system with ECSEC. Parameters evaluated were technical success, technical efficacy, tumour diameter, tumour and ablation volume, complication rate, 90-day mortality, local tumour progression (LTP) at the 12-month follow-up, ablative margin and ablation zone sphericity...
August 3, 2017: International Journal of Hyperthermia
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