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Liver ablation

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https://www.readbyqxmd.com/read/28214976/defining-the-optimal-use-of-ablation-for-metastatic-colorectal-cancer-to-the-liver-without-high-level-evidence
#1
REVIEW
Rafael Diaz-Nieto, Stephen Fenwick, Hassan Malik, Graeme Poston
The role of physical interventions (surgical resection and surgical/radiological ablation) for liver metastases of colorectal cancer has changed dramatically over the last 10-15 years. Whereas in the 1990s, when only those patients with up to three unilobar metastases were considered for any form of such intervention, our present approach to these physical interventions is determined by how much viable disease-free liver can be preserved (most authorities accepting 25-30% disease-free future remnant liver volume) and the possibility of further such interventions if the disease recurs in the liver...
February 2017: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/28205111/risk-factors-for-bile-duct-injury-after-percutaneous-thermal-ablation-of-malignant-liver-tumors-a-retrospective-case-control-study
#2
Man-Xia Lin, Jie-Yi Ye, Wen-Shuo Tian, Ming Xu, Bo-Wen Zhuang, Ming-De Lu, Xiao-Yan Xie, Ming Kuang
BACKGROUND: Bile duct injury after ablation of malignant liver tumors (MLTs) was not unusual and should be avoided. However, few studies have focused on evaluating the risk factors for intrahepatic bile duct injury. AIM: To evaluate the risk factors for intrahepatic bile duct injury after ablation of MLTs and to evaluate the minimum safe distance for ablating tumors abutting bile ducts. METHODS: Sixty-five patients with intrahepatic bile duct injury after ablation of MLTs, and 65 controls were recruited...
February 15, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28196771/liver-metastases-from-breast-cancer-what-role-for-surgery-indications-and-results
#3
REVIEW
Nicolas Golse, René Adam
Liver metastases from breast cancer (LMBC) have long been considered as a systemic disease because of the hematological route of dissemination, requiring noncurative management. In fact, despite recent advances in drug therapies personalized to tumor phenotype, the chances of a cure are nil and there is little hope of long-term survivors after nonsurgical management alone. By contrast, there is a growing evidence in the literature for satisfactory long-term results after a combination of chemotherapy and liver resection, with 5-year survival reaching >40% in some series...
January 9, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28196353/importance-of-screening-for-esophagogastric-varices-in-na%C3%A3-ve-hepatocellular-carcinoma-patients-within-milan-criteria-indicator-for-liver-transplantation
#4
Takamasa Kawakami, Atsushi Hiraoka, Kojiro Michitaka, Tomoyuki Ninomiya, Masashi Hirooka, Yoichi Hiasa
BACKGROUND/AIMS: Patients with hepatocellular carcinoma (HCC) beyond Milan criteria (MC) are not eligible for liver transplantation (LT). To elucidate prognostic factors significantly linked to recurrence beyond MC or death related to the liver, we evaluated the clinical features in a series of HCC patients within MC at baseline. METHODS: We enrolled 255 naïve HCC patients (≤70 years) within the MC who underwent upper-gastrointestinal-endoscopy, and were treated with resection or radiofrequency ablation (62 years old [median]; male:female = 202:53; Child-Pugh A:B = 216:39)...
February 15, 2017: Digestive Surgery
https://www.readbyqxmd.com/read/28193132/finding-optimal-ablation-parameters-for-multipolar-radiofrequency-ablation
#5
Franz G M Poch, Christian Rieder, Hanne Ballhausen, Verena Knappe, Jörg Peter Ritz, Ole Gemeinhardt, Martin E Kreis, Kai S Lehmann
PURPOSE: Radiofrequency ablation (RFA) for primary liver tumors and liver metastases is restricted by a limited ablation size. Multipolar RFA is a technical advancement of RFA, which is able to achieve larger ablations. The aim of this ex vivo study was to determine optimal ablation parameters for multipolar RFA depending on applicator distance and energy input. METHODS: RFA was carried out ex vivo in porcine livers with three internally cooled, bipolar applicators in multipolar ablation mode...
February 1, 2017: Surgical Innovation
https://www.readbyqxmd.com/read/28192185/hepatic-decompensation-is-the-major-driver-of-death-in-hcv-infected-cirrhotic-patients-with-successfully-treated-early-hepatocellular-carcinoma
#6
Giuseppe Cabibbo, Salvatore Petta, Marco Barbara, Simona Attardo, Laura Bucci, Fabio Farinati, Edoardo G Giannini, Giulia Negrini, Francesca Ciccarese, Gian Lodovico Rapaccini, Maria Di Marco, Eugenio Caturelli, Marco Zoli, Franco Borzio, Rodolfo Sacco, Roberto Virdone, Fabio Andrea Marra Mega, Filomena Morisco, Luisa Benvegnù, Antonio Gasbarrini, Gianluca Svegliati-Baroni, Francesco Giuseppe Foschi, Andrea Olivani, Alberto Masotto, Gerardo Nardone, Antonio Colecchia, Marcello Persico, Antonio Craxì, Franco Trevisani, Calogero Cammà
BACKGROUND & AIMS: A major problem in assessing the long-term outcome of HCV-infected cirrhotic patients with successfully treated Barcelona Clinic Liver Cancer (BCLC) A hepatocellular carcinoma (HCC) arises from the lack of models accounting for early changes during follow-up. AIM: of study is to estimate the impact on 5-year overall survival (OS) of early (occurring within 12 months after complete radiological response) time-dependents events (HCC recurrence or hepatic decompensation) in a large cohort of successfully treated HCC patients with HCV cirrhosis...
February 9, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28191906/intracardiac-echocardiography-for-verification-for-left-atrial-appendage-thrombus-presence-detected-by-transesophageal-echocardiography-the-actionice-ii-study
#7
Jakub Baran, Beata Zaborska, Roman Piotrowski, Malgorzata Sikora-Frąc, Ewa Pilichowska-Paszkiet, Piotr Kułakowski
BACKGROUND: Transesophageal echocardiography (TEE) remains the gold standard for exclusion of left atrial appendage (LAA) thrombus in patients scheduled for direct electrical cardioversion (DEC) or atrial fibrillation (AF) ablation. Recently, intracardiac echocardiography (ICE) of the pulmonary artery (PA) has been shown to provide excellent LAA images and to be useful in verification of equivocal TEE findings. HYPOTHESIS: ICE of the PA may have a role in detecting false-positive TEE results...
February 13, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28190707/safety-and-efficacy-of-percutaneous-microwave-hepatic-ablation-near-the-heart
#8
George A Carberry, Amanda R Smolock, Mircea Cristescu, Shane A Wells, Timothy J Ziemlewicz, Meghan G Lubner, J Louis Hinshaw, Christopher L Brace, Fred T Lee
PURPOSE: To evaluate safety and efficacy of percutaneous hepatic microwave (MW) ablation performed near the heart. MATERIALS AND METHODS: This study reviewed 118 consecutive peripheral (ablation zone margins within 5 mm of liver capsule) percutaneous MW hepatic ablations performed between June 2010 and August 2015. Ablation zones of 27 tumors (22.8%) extended to ≤ 5 mm from myocardium, and these ablations comprised the study group; the remaining ablations formed the control group...
February 9, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28187878/embryonic-origin-of-primary-colon-cancer-predicts-survival-in-patients-undergoing-ablation-for-colorectal-liver-metastases
#9
S Yamashita, B C Odisio, S Y Huang, S E Kopetz, K Ahrar, Y S Chun, C Conrad, T A Aloia, S Gupta, S Harmoush, M E Hicks, J-N Vauthey
BACKGROUND: In patients with primary colorectal cancer (CRC) or unresectable metastatic CRC, midgut embryonic origin is associated with worse prognosis. The impact of embryonic origin on survival after ablation of colorectal liver metastases (CLM) is unclear. METHODS: We identified 74 patients with CLM who underwent percutaneous ablation during 2004-2015. Survival and recurrence after ablation of CLM from midgut origin (n = 18) and hindgut origin (n = 56) were analyzed...
January 29, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28187746/slow-lung-clearance-and-limited-translocation-of-four-sizes-of-inhaled-iridium-nanoparticles
#10
Alison Buckley, James Warren, Alan Hodgson, Tim Marczylo, Konstantin Ignatyev, Chang Guo, Rachel Smith
BACKGROUND: Concerns have been expressed that inhaled nanoparticles may behave differently to larger particles in terms of lung clearance and translocation, with potential implications for their toxicity. Studies undertaken to investigate this have typically involved limited post-exposure periods. There is a shortage of information on longer-term clearance and translocation patterns and their dependence on particle size, which this study aimed to address. METHODS: Rats were exposed (<3 h) nose-only to aerosols of spark-generated radioactive iridium-192 nanoparticles of four sizes: 10 nm, 15 nm, 35 nm and 75 nm (count median diameter) (aerosol mass concentrations 17, 140, 430, and 690 μg/m(3), respectively)...
February 10, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/28185998/study-on-the-effect-of-chemoembolization-combined-with-microwave-ablation-for-the-treatment-of-hepatocellular-carcinoma-in-rats
#11
Thomas Josef Vogl, Jun Qian, Andreas Tran, Elsie Oppermann, Nagy N Naguib, Huedayi Korkusuz, Nour Eldin A Nour Eldin, Wolf Otto Bechstein
PURPOSE: We aimed to evaluate the combining effects of transarterial chemoembolization (TACE) and open local thermal microwave ablation (MWA) in a hepatocellular carcinoma animal model. METHODS: Tumor cubes were implanted into the liver of 30 male inbred ACI rats. Groups of 10 animals were treated at 13 days (TACE or MWA) and 16 days (MWA) postimplantation with combined therapy (study group A) of TACE (0.1 mg mitomycin C; 0.1 mg iodized oil; 5.0 mg degradable starch microspheres) and MWA (2450 Mhz; 45 s; 35 W), TACE (control group B) or MWA (control group C) alone...
February 10, 2017: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/28185302/patterns-and-challenges-of-treatment-sequencing-in-patients-with-hepatocellular-carcinoma-experience-from-a-referral-center
#12
Martha M Kirstein, Nora Schweitzer, Theresa Winter, Katerina Lappas, Nathalie Graen, Isabell Kunstmann, Torsten Voigtländer, Tanja Reineke-Plaaß, Michael P Manns, Frank Lehner, Thomas Rodt, Arndt Vogel
BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most prevalent and lethal cancers. Several local and systemic therapies are available for patients with HCC depending on the stage of the disease. In clinical practice, treatment decision-making and sequencing may be very heterogeneous. METHODS: In this study, we retrospectively analyzed treatment algorithms in 2,101 patients with HCC treated from 2000 to 2015 at Hannover Medical School, Germany. RESULTS: Transarterial chemoembolization (TACE) was the most common initial treatment (n = 545; 25...
February 10, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28184942/radiological-biomarkers-for-assessing-response-to-locoregional-therapies-in-hepatocellular-carcinoma-from-morphological-to-functional-imaging-review
#13
Xiao-Dan Ye, Zuguo Yuan, Jian Zhang, Zheng Yuan
Many hepatocellular carcinoma (HCC) patients do not qualify for curative surgical intervention and are instead treated with locoregional therapies (LRTs) including ablative and endovascular therapies. Assessment of imaging response is essential in the management of HCC for determining efficacy of therapy and as a surrogate marker for improved survival. The established morphological image biomarkers for tumor burden measurement continue to be applied, as size measurement can easily be used in clinical practice...
March 2017: Oncology Reports
https://www.readbyqxmd.com/read/28183446/genetic-ablation-of-phosphatidylcholine-transfer-protein-stard2-in-ob-ob-mice-improves-glucose-tolerance-without-increasing-energy-expenditure
#14
Tibor I Krisko, Katherine B LeClair, David E Cohen
OBJECTIVE: Phosphatidylcholine transfer protein (PC-TP; synonym StarD2) is highly expressed in liver and oxidative tissues. PC-TP promotes hepatic glucose production during fasting and aggravates glucose intolerance in high fat fed mice. However, because PC-TP also suppresses thermogenesis in brown adipose tissue (BAT), its direct contribution to obesity-associated diabetes in mice remains unclear. Here we examined the effects of genetic PC-TP ablation on glucose homeostasis in leptin-deficient ob/ob mice, which exhibit both diabetes and altered thermoregulation...
March 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28182306/effect-of-a-hypoxic-microenvironment-after-radiofrequency-ablation-on-residual-hepatocellular-cell-migration-and-invasion
#15
Yuyang Tong, Haiyun Yang, Xiaolin Xu, Jingliang Ruan, Ming Liang, Jiayi Wu, Baoming Luo
Clinical observations have shown that the boundary of tumor ablation is often less than safe border and that the use of radiofrequency ablation (RFA) in the treatment of hepatocellular carcinoma (HCC) may probably accelerate its recurrence and metastasis. RFA can cause the formation of a transition zone between normal liver tissues and necrotic coagulation, where blood stagnation and thrombosis expose residual cancer cells to a hypoxic microenvironment. As the blocked vessels are slowly reperfused, the oxygen supply is gradually restored...
February 9, 2017: Cancer Science
https://www.readbyqxmd.com/read/28180965/-18-f-fdg-pet-as-novel-imaging-biomarker-for-disease-progression-after-ablation-therapy-in-colorectal-liver-metastases
#16
M Samim, W Prevoo, B J de Wit-van der Veen, K F Kuhlmann, T Ruers, R van Hillegersberg, M A A J van den Bosch, H M Verkooijen, M G E H Lam, M P M Stokkel
PURPOSE: Recurrent disease following thermal ablation therapy is a frequently reported problem. Preoperative identification of patients with high risk of recurrent disease might enable individualized treatment based on patients' risk profile. The aim of the present work was to investigate the role of metabolic parameters derived from the pre-ablation (18)F-FDG PET/CT as imaging biomarkers for recurrent disease in patients with colorectal liver metastases (CLM). METHODS: Included in this retrospective study were all consecutive patients with CLM treated with percutaneous or open thermal ablation therapy who had a pre-treatment baseline (18)F-FDG PET/CT available...
February 8, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28180923/early-assessment-of-coagulation-necrosis-after-hepatic-microwave-ablation-a-comparison-of-non-enhanced-and-enhanced-t1-weighted-images
#17
Zhen-Yu Jia, Qi-Feng Chen, Zheng-Qiang Yang, Wen-Tao Wu, Hai-Bin Shi, Sheng Liu
PURPOSE: To compare the technical success and accuracy of hepatic microwave ablation (MWA) using non-enhanced and enhanced T1-weighted imaging early after ablation. Patients were evaluated with regard to the ablation zone and local tumor progression (LTP). METHODS: This retrospective study conducted between September 2014 and December 2015 which consisted of 56 patients with 56 hepatic malignant lesions who underwent percutaneous MWA. Non-enhanced and contrast-enhanced T1-weighted imagings were performed within 2 days after tumor ablation...
February 8, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28177652/irreversible-electroporation-defining-the-mri-appearance-of-the-ablation-zone-with-histopathologic-correlation-in-a-porcine-liver-model
#18
Ely R Felker, Isabel Dregely, Dong Jin Chung, Kyunghyun Sung, Ferdnand C Osuagwu, Charles Lassman, James Sayre, Holden Wu, David S Lu
OBJECTIVE: The purpose of this study is to evaluate the MRI appearance of the irreversible electroporation zone in porcine liver, with histopathologic correlation. MATERIALS AND METHODS: Nine irreversible electroporation ablations were percutaneously created in two Yorkshire pigs. Irreversible electroporation was performed with a bipolar 16-gauge electrode with 3-cm exposure tip and fixed 8-mm interpolar distance. Gadoxetate disodium-enhanced 3-T MRI was performed 50 hours after irreversible electroporation...
February 8, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28176349/early-detection-and-curative-treatment-of-hepatocellular-carcinoma-a-cost-effectiveness-analysis-in-france-and-in-the-united-states
#19
Benjamin Cadier, Julie Bulsei, Pierre Nahon, Olivier Seror, Alexis Laurent, Isabelle Rosa, Richard Layese, Charlotte Costentin, Carole Cagnot, Isabelle Durand-Zaleski, Karine Chevreul
: Hepatocellular carcinoma (HCC) is the leading cause of death in patients with cirrhosis. Patients outside clinical trials seldom benefit from evidence-based monitoring. The objective of this study was to estimate the cost-effectiveness of complying with HCC screening guidelines. The economic evaluation compared surveillance of patients with cirrhosis as recommended by the guidelines ("gold-standard monitoring") to "real-life monitoring" from the health care system perspective. A Markov model described the history of the disease and treatment course including current first-line curative treatment: liver resection, radiofrequency ablation (RFA), and liver transplantation...
February 8, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28170115/radiofrequency-ablation-of-hepatocellular-carcinoma-as-bridge-therapy-to-liver-transplantation-a-ten-year-intention-to-treat-analysis
#20
Min Woo Lee, Steven S Raman, Nazanin H Asvadi, Surachate Siripongsakun, Robert M Hicks, Jeffrey Chen, Akeanong Worakitsitisatorn, Justin McWilliams, Myron J Tong, Richard S Finn, Vatche G Agopian, Ronald W Busuttil, David S K Lu
: In a long-term (10 years) study of radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC) as bridging therapy in patients listed for orthotopic liver transplantation (LT), we evaluated the impact of RFA on waiting list dropout rate, post-LT tumor recurrence, and long-term intention to treat, disease-specific survival. From March 2004 to October 2014, RFA was performed as the initial stand-alone bridge therapy to LT for 121 patients (male:female = 83:38; mean age, 60.0 years) with 156 de-novo HCCs (mean size: 2...
February 7, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
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