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Liver ablation

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https://www.readbyqxmd.com/read/28547928/application-of-endobronchial-ultrasonography-in-laparoscopic-liver-segmentectomy-in-an-animal-model
#1
Tomoyuki Abe, Tsuyoshi Kobayashi, Seiichi Shimizu, Michinori Hamaoka, Hiroshi Iwako, Masakazu Hashimoto, Yoshihiro Mikuriya, Shintaro Kuroda, Hirotaka Tashiro, Hideki Ohdan
INTRODUCTION: This study investigated whether laparoscopic ultrasound-guided segment staining and real-time ultrasound-guided hepatectomy, with endobronchial ultrasonography equipped with a guide sheath, would be useful for laparoscopic liver segmentectomy in a porcine model. MATERIAL AND SURGICAL TECHNIQUE: The abdominal cavity (in two pigs) was reached via a 12-mm umbilical trocar. An artificial tumor was created by radiofrequency ablation within the intended resection area...
May 2017: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/28547649/hklc-triages-more-hepatocellular-carcinoma-patients-to-curative-therapies-compared-to-bclc-and-is-associated-with-better-survival
#2
Michael C Wallace, Yi Huang, David B Preen, George Garas, Leon A Adams, Gerry MacQuillan, Jonathan Tibballs, John Ferguson, Shaun Samuelson, Gary P Jeffrey
BACKGROUND AND AIMS: The Hong Kong Liver Cancer (HKLC) system proposes to triage hepatocellular carcinoma (HCC) patients to more aggressive treatment and may be associated with superior survival compared with the Barcelona Clinic Liver Cancer (BCLC) system. We aimed to identify the influence of adherence to HKLC or BCLC treatment recommendations on survival and time to progression. METHODS: We examined a prospectively enrolled cohort of 292 patients undergoing 532 treatment episodes from a single clinical center...
May 25, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28545858/hemocoagulase-combined-with-microbubble-enhanced-ultrasound-cavitation-for-augmented-ablation-of-microvasculature-in-rabbit-vx2-liver-tumors
#3
Qian Yang, Peng Tang, Guangbin He, Shuping Ge, Liwen Liu, Xiaodong Zhou
We investigated a new method for combining microbubble-enhanced ultrasound cavitation (MEUC) with hemocoagulase (HC) atrox. Our goal was to induce embolic effects in the vasculature and combine these with an anti-angiogenic treatment strategy. Fourteen days after being implanted with a single slice of the liver VX2 tumor, rabbits were randomly divided into five groups: (i) a control group injected intra-venously with saline using a micropump; (ii) a group given only an injection of HC; (iii) a group treated only with ultrasound cavitation; (iv) a group treated with MEUC; (v) a group treated with MEUC + HC...
May 22, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28545181/hepatocellular-carcinoma-a-comprehensive-review-of-biomarkers-clinical-aspects-and-therapy
#4
Nathalia Martines Tunissiolli, Márcia Maria Urbanin Castanhole-Nunes, Patrícia Matos Biselli-Chicote, Érika Cristina Pavarino, Renato Ferreira da Silva, Rita de Cássia Martins Alves da Silva, Eny Maria Goloni-Bertollo
Hepatocellular carcinoma (HCC) is a cause of several deaths related to cancer worldwidely. In early stage, curative treatments such as surgical resection, liver transplant and local ablation can improve the patient ´s survival. However, the disease is detected in advanced stage; moreover some available therapies are restricted to palliative care and local treatment. Early detections of HCC and adequate therapy are crucial to increase survival as well as to improve the patient´s quality of life. Therefore, researchers have been investigating molecular biomarkers with high sensibility and reliability as Golgi 73 protein (GP73), Glypican-3 (GPC3), Osteopontin (OPN), microRNAs and others...
April 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28545098/survival-and-prognostic-factors-for-patients-with-advanced-hepatocellular-carcinoma-after-stereotactic-ablative-radiotherapy
#5
Cheng-Hsiang Lo, Jen-Fu Yang, Ming-Yueh Liu, Yee-Min Jen, Chun-Shu Lin, Hsing-Lung Chao, Wen-Yen Huang
OBJECTIVE: To evaluate the survival outcomes and prognostic factors of patients with advanced hepatocellular carcinoma (HCC) who underwent stereotactic ablative radiotherapy (SABR). METHODS: This retrospective study evaluated patients with advanced HCC who underwent SABR between December 2007 and July 2015. All patients had Barcelona Clinic Liver Cancer stage C disease and Child-Turcotte-Pugh (CTP) class A-B function. In-field control (IFC), overall survival (OS), prognostic factors, and toxicity were evaluated...
2017: PloS One
https://www.readbyqxmd.com/read/28543540/computational-modeling-of-915-mhz-microwave-ablation-comparative-assessment-of-temperature-dependent-tissue-dielectric-models
#6
Garron Deshazer, Mark Hagmann, Derek Merck, Jan Sebek, Kent B Moore, Punit Prakash
PURPOSE: The objective of this study is to develop a computational model for simulating 915 MHz microwave ablation (MWA), and verify the simulation predictions of transient temperature profiles against experimental measurements. Due to the limited experimental data characterizing temperature-dependent changes of tissue dielectric properties at 915 MHz, we comparatively assess two temperature dependent approaches of modeling of dielectric properties: model A- piecewise linear temperature dependencies based on existing, but limited, experimental data, and model B- similar to model A, but augmented with linear decrease in electrical conductivity above 95 °C, as guided by our experimental measurements...
May 23, 2017: Medical Physics
https://www.readbyqxmd.com/read/28543100/syndecan-1-limits-the-progression-of-liver-injury-and-promotes-liver-repair-in-acetaminophen-induced-liver-injury
#7
Eon Jeong Nam, Kazutaka Hayashida, Rafael S Aquino, John R Couchman, Rosemary A Kozar, Jian Liu, Pyong Woo Park
Accidental or intentional misuse of acetaminophen (APAP) is the leading cause of acute liver failure in the Western world. While mechanisms that trigger APAP-induced liver injury are well known, those that halt the progression of APAP liver disease and facilitate liver recovery are less understood. Heparan sulfate proteoglycans (HSPGs) bind to and regulate various tissue injury factors through their heparan sulfate (HS) chains, but the importance of HSPGs in liver injury in vivo remains unknown. Here, we examined the role of syndecan-1, the major cell surface HSPG of hepatocytes, in APAP-induced liver injury...
May 22, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28542246/a-drastic-superoxide-dependent-oxidative-stress-is-prerequisite-for-the-down-regulation-of-irp1-insights-from-studies-on-sod1-deficient-mice-and-macrophages-treated-with-paraquat
#8
Anna Milczarek, Rafał R Starzyński, Agnieszka Styś, Aneta Jończy, Robert Staroń, Agnieszka Grzelak, Paweł Lipiński
Iron regulatory protein 1 (IRP1) is a cytosolic bifunctional [4Fe-4S] protein which exhibits aconitase activity or binds iron responsive elements (IREs) in untranslated regions of specific mRNA encoding proteins involved in cellular iron metabolism. Superoxide radical (O2.-) converts IRP1 from a [4Fe-4S] aconitase to a [3Fe-4S] "null" form possessing neither aconitase nor trans-regulatory activity. Genetic ablation of superoxide dismutase 1 (SOD1), an antioxidant enzyme that acts to reduce O2.- concentration, revealed a new O2...
2017: PloS One
https://www.readbyqxmd.com/read/28540818/long-term-outcome-of-percutaneous-radiofrequency-ablation-in-recurrent-hepatocellular-carcinoma-after-liver-transplantation
#9
Wei Yang, Hao Wu, Zhong-Yi Zhang, Jung-Chieh Lee, Song Wang, Yan-Jie Wang, Wei Wu, Min-Hua Chen, Kun Yan
PURPOSE: To investigate the long-term outcome and prognostic factors of radiofrequency ablation (RFA) in recurrent hepatocellular carcinoma (HCC) after liver transplantation (LT). METHODS: From 2004 to 2014, 15 patients with 23 hepatic recurrent HCCs after LT underwent ultrasound-guided percutaneous RFA. There were 14 males and 1 female aged 54.3 ± 9.5 years old (37-78 years old). The average tumour size was 3.3 ± 1.2 cm (1.7-6.0 cm). Seven patients had a single HCC and eight had 2-4 HCCs...
May 16, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28540805/the-in-vivo-performance-of-a-novel-thermal-accelerant-agent-used-for-augmentation-of-microwave-energy-delivery-within-biologic-tissues-during-image-guided-thermal-ablation-a-porcine-study
#10
William Keun Chan Park, Aaron Wilhelm Palmer Maxwell, Victoria Elizabeth Frank, Michael Patrick Primmer, Jarod Brian Paul, Scott Andrew Collins, Kara Anne Lombardo, Shaolei Lu, Tiffany Marie Borjeson, Grayson Luderman Baird, Damian Edward Dupuy
OBJECTIVES: To investigate the effects of a novel caesium-based thermal accelerant (TA) agent on ablation zone volumes following in vivo microwave ablation of porcine liver and skeletal muscle, and to correlate the effects of TA with target organ perfusion. MATERIALS AND METHODS: This prospective study was performed following institutional animal care and use committee approval. Microwave ablation was performed in liver and resting skeletal muscle in eight Sus scrofa domesticus swine following administration of TA at concentrations of 0 mg/mL (control), 100 mg/mL and 250 mg/mL...
April 24, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28540787/microwave-ablation-is-effective-against-liver-metastases-from-gastric-adenocarcinoma
#11
Fubo Zhou, Xiao-Ling Yu, Ping Liang, Zhigang Cheng, Zhi-Yu Han, Jie Yu, Fangyi Liu, Yi Hu
PURPOSE: The resection rate for liver metastases from gastric cancer is only 1.4-21.1%. This study aimed to evaluate the safety and therapeutic efficacy of microwave ablation (MWA) for liver metastases from gastric adenocarcinoma (LMGC). MATERIALS AND METHODS: A database of 108 gastric adenocarcinoma patients with liver metastases who underwent MWA (n = 32) or systemic chemotherapy (n = 76) for LMGC between 2008 and 2016 was reviewed. Overall survival curves were assessed and compared based on different therapies...
March 29, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28540784/safety-and-efficacy-of-radiofrequency-assisted-alpps-ralpps-in-patients-with-cirrhosis-related-hepatocellular-carcinoma
#12
Qiang Wang, Jun Yan, Xiaobin Feng, Geng Chen, Feng Xia, Xiaowu Li, Kuansheng Ma, Ping Bie
BACKGROUND AND AIMS: Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) has high morbidity and mortality. In this study, the safety and efficacy of a modification of ALPPS (radiofrequency-assisted ALPPS, RALPPS) were assessed in patients with hepatocellular carcinoma (HCC). MATERIALS AND METHODS: Patients who were diagnosed with HCC and were considered to have an insufficient future liver remnant (FLR) were enrolled. In stage I, a radiofrequency ablation (RFA) device was used to cauterise along the planned transection plane to form a coagulum avascular area...
March 23, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28540782/computational-modelling-of-internally-cooled-wet-icw-electrodes-for-radiofrequency-ablation-impact-of-rehydration-thermal-convection-and-electrical-conductivity
#13
Macarena Trujillo, Jose Bon, Enrique Berjano
PURPOSE: (1) To analyse rehydration, thermal convection and increased electrical conductivity as the three phenomena which distinguish the performance of internally cooled electrodes (IC) and internally cooled wet (ICW) electrodes during radiofrequency ablation (RFA), (2) Implement a RFA computer model with an ICW which includes these phenomena and (3) Assess their relative influence on the thermal and electrical tissue response and on the coagulation zone size. METHODS: A 12-min RFA in liver was modelled using an ICW electrode (17 G, 3 cm tip) by an impedance-control pulsing protocol with a constant current of 1...
March 21, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28540775/preventing-intrahepatic-infection-after-ablation-of-liver-tumours-in-biliary-enteric-anastomosis-patients
#14
Shui-Lian Tan, Xiao-Ling Yu, Ping Liang, Fangyi Liu, Zhigang Cheng, Zhi-Yu Han, Jie Yu
PURPOSE: To assess the value of bowel preparation plus targeted antibiotics for preventing intrahepatic infections after MWA of liver tumours in BEA patients. MATERIALS AND METHODS: This retrospective study included 21 patients (divided into two groups) with a history of BEA undergoing ultrasound-guided MWA of liver tumours from November 2008 to June 2014. Group A (n = 10) received single-antibiotic therapy (cefazedone 2 g bid 4, amoxicillin and flucloxacillin sodium 2 g bid 3, levofloxacin 0...
February 28, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28537410/-liver-hemangiomas-when-is-invasive-treatment-indicated
#15
V Třeška, T Skalický, V Liška, J Fichtl, J Brůha, M Skála, J Šebek, P Duras
INTRODUCTION: Liver hemangiomas are the most common benign tumors of the liver. Most are asymptomatic and are found accidentally by ultrasonography, computed tomography or magnetic resonance imaging of the abdomen. Liver hemangiomas usually do not need any treatment. Nevertheless, symptomatic, giant hemangiomas can be indicated for surgery, embolization or thermoablation. The aim of this study was to define based on our own experience and on the literature when and what treatment option should be indicated in patients suffering from liver hemangioma...
2017: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://www.readbyqxmd.com/read/28529987/the-role-of-radiofrequency-ablation-to-liver-transection-surface-in-patients-with-close-tumor-margin-of-hcc-during-hepatectomy-a-case-matched-study
#16
C Nicholas Kotewall, Tan To Cheung, Wong Hoi She, Ka Wing Ma, Simon Hing Ying Tsang, Jeff Wing Chiu Dai, Albert Chi Yan Chan, Kenneth Siu Ho Chok, Chung Mau Lo
BACKGROUND: To review the outcome of using radiofrequency ablation (RFA) for patients with close resection margin during hepatectomy. METHODS: From Oct 2004 to Sept 2013, 862 patients received hepatectomy for hepatocellular carcinoma (HCC) in the Department of Surgery, Queen Mary Hospital in Hong Kong. Fourteen patients received additional RFA because of close resection margin (<1 cm) during the operation for HCC. The result of 28 patients with close liver resection margin was selected for comparison...
2017: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28528576/using-non-thermal-irreversible-electroporation-to-create-an-in-vivo-niche-for-exogenous-cell-engraftment
#17
Tammy T Chang, Vivian X Zhou, Boris Rubinsky
The critical shortage of donor organs has spurred investigation of alternative approaches to either generate replacement organs or implant exogenous cells for treatment of end-stage organ failure. Non-thermal irreversible electroporation (NTIRE), which uses brief high electric field pulses to induce irreversible permeabilization of cell membranes, has emerged as a technique for tumor ablation. Here, we introduce a new application for NTIRE that employs in situ cell ablation to create a niche within a solid organ for engraftment of exogenous cells in vivo...
May 1, 2017: BioTechniques
https://www.readbyqxmd.com/read/28527884/adjuvant-medications-that-improve-survival-after-locoregional-therapy
#18
F Edward Boas, Etay Ziv, Hooman Yarmohammadi, Karen T Brown, Joseph P Erinjeri, Constantinos T Sofocleous, James J Harding, Stephen B Solomon
PURPOSE: To determine if outpatient medications taken at the time of liver tumor embolization or ablation affect survival. MATERIALS AND METHODS: A retrospective review was done of 2,032 liver tumor embolization, radioembolization, and ablation procedures performed in 1,092 patients from June 2009 to April 2016. Pathology, hepatocellular carcinoma (HCC) stage (American Joint Committee on Cancer), neuroendocrine tumor (NET) grade, initial locoregional therapy, overall survival after initial locoregional therapy, Child-Pugh score, Eastern Cooperative Oncology Group performance status, Charlson Comorbidity Index, and outpatient medications taken at the time of locoregional therapy were analyzed for each patient...
May 17, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28525365/the-clinical-utility-and-outcomes-of-microwave-ablation-for-colorectal-cancer-liver-metastases
#19
Pengyuan Song, Lijun Sheng, Yahong Sun, Yuji An, Ya Guo, Yafei Zhang
In recent years, the microwave ablation (MWA) has been reported to play an important role in the treatment of patients with colorectal liver metastases (CRLM). In this work, 62 cases of patients who received MWA for liver metastases from colon or rectal cancer between Jan 2012 and Jan 2014 were enrolled in this trial. 28 underwent MWA, and 34 were treated with liver resection as control. Perioperative and 60 months of follow-up data were collected to analyze potential adverse effects, concurrent conditions and survival status...
February 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28522174/results-after-surgical-treatment-of-liver-metastases-in-patients-with-high-grade-gastroenteropancreatic-neuroendocrine-carcinomas
#20
R B Galleberg, U Knigge, E Tiensuu Janson, L W Vestermark, S-P Haugvik, M Ladekarl, S W Langer, H Grønbæk, P Österlund, G O Hjortland, J Assmus, L Tang, A Perren, H Sorbye
BACKGROUND: Gastroenteropancreatic neuroendocrine carcinomas (GEP-NEC) are generally characterized by synchronous metastases, high aggressiveness and a dismal prognosis. Current international guidelines do not recommend surgical treatment of liver metastases, however the existing data are scarce. The aim of this study was to evaluate the results of curatively intended resection/radiofrequency ablation (RFA) of liver metastases in patients with metastatic GEP-NEC. METHODS: 32 patients with a diagnosis of high-grade gastroenteropancreatic neuroendocrine neoplasm (Ki-67 > 20%) and with intended curative resection/RFA of liver metastases, were identified among 840 patients from two Nordic GEP-NEC registries...
May 4, 2017: European Journal of Surgical Oncology
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