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https://www.readbyqxmd.com/read/29339752/prognostic-performance-of-ten-liver-function-models-in-patients-with-hepatocellular-carcinoma-undergoing-radiofrequency-ablation
#1
Shu-Yein Ho, Po-Hong Liu, Chia-Yang Hsu, Yi-You Chiou, Chien-Wei Su, Yun-Hsuan Lee, Yi-Hsiang Huang, Fa-Yauh Lee, Ming-Chih Hou, Teh-Ia Huo
Liver functional capacity is a crucial survival determinant for hepatocellular carcinoma (HCC). Noninvasive models were proposed to assess hepatic reserve, but their performance in outcome prediction is unclear. We aimed to investigate 10 currently used liver function models in HCC patients undergoing radiofrequency ablation (RFA). A total 499 HCC patients were prospectively identified. Homogeneity and corrected Akaike information criteria (AICc) were compared. Cox proportional hazards model was used to identify independent survival predictors...
January 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29339491/kinase-independent-function-of-e-type-cyclins-in-liver-cancer
#2
Yan Geng, Wojciech Michowski, Joel M Chick, Yaoyu E Wang, M Emmanuelle Jecrois, Katharine E Sweeney, Lijun Liu, Richard C Han, Nan Ke, Agnieszka Zagozdzon, Ewa Sicinska, Roderick T Bronson, Steven P Gygi, Piotr Sicinski
E-type cyclins (cyclins E1 and E2) are components of the core cell cycle machinery and are overexpressed in many human tumor types. E cyclins are thought to drive tumor cell proliferation by activating the cyclin-dependent kinase 2 (CDK2). The cyclin E1 gene represents the site of recurrent integration of the hepatitis B virus in the pathogenesis of hepatocellular carcinoma, and this event is associated with strong up-regulation of cyclin E1 expression. Regardless of the underlying mechanism of tumorigenesis, the majority of liver cancers overexpress E-type cyclins...
January 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29335429/rfa-guardian-comprehensive-simulation-of-radiofrequency-ablation-treatment-of-liver-tumors
#3
Philip Voglreiter, Panchatcharam Mariappan, Mika Pollari, Ronan Flanagan, Roberto Blanco Sequeiros, Rupert Horst Portugaller, Jurgen Fütterer, Dieter Schmalstieg, Marina Kolesnik, Michael Moche
The RFA Guardian is a comprehensive application for high-performance patient-specific simulation of radiofrequency ablation of liver tumors. We address a wide range of usage scenarios. These include pre-interventional planning, sampling of the parameter space for uncertainty estimation, treatment evaluation and, in the worst case, failure analysis. The RFA Guardian is the first of its kind that exhibits sufficient performance for simulating treatment outcomes during the intervention. We achieve this by combining a large number of high-performance image processing, biomechanical simulation and visualization techniques into a generalized technical workflow...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29333633/long-term-outcome-of-stereotactic-body-radiotherapy-for-patients-with-small-hepatocellular-carcinoma
#4
Katsumaro Kubo, Tomoki Kimura, Hiroshi Aikata, Shigeo Takahashi, Yuki Takeuchi, Ippei Takahashi, Ikuno Nishibuchi, Yuji Murakami, Kazuaki Chayama, Yasushi Nagata
AIM: To evaluate the long-term outcome of stereotactic body radiotherapy in patients with small hepatocellular carcinoma who were ineligible for resection or ablation therapies. METHODS: Sixty-five patients with 74 hepatocellular carcinomas (median tumor size, 16 mm) were enrolled in this study. They were treated with the prescribed dose of 48 Gy in four fractions at the isocenter. We extended the observation period and analyzed long-term outcomes, including overall survival, progression-free survival, local control, and various prognostic factors, in these patients...
January 14, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29327594/liver-resection-and-surgical-strategies-for-management-of-primary-liver-cancer
#5
Sonia T Orcutt, Daniel A Anaya
Primary liver cancer-including hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC)-incidence is increasing and is an important source of cancer-related mortality worldwide. Management of these cancers, even when localized, is challenging due to the association with underlying liver disease and the complex anatomy of the liver. Although for ICC, surgical resection provides the only potential cure, for HCC, the risks and benefits of the multiple curative intent options must be considered to individualize treatment based upon tumor factors, baseline liver function, and the functional status of the patient...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/29327179/liver-transplantation-is-equally-effective-as-a-salvage-therapy-for-patients-with-hepatocellular-carcinoma-recurrence-following-radiofrequency-ablation-or-liver-resection-with-curative-intent
#6
Hala Muaddi, David P Al-Adra, Rob Beecroft, Anand Ghanekar, Carol-Anne Moulton, Adam Doyle, Markus Selzner, Alice Wei, Ian D McGilvray, Steven Gallinger, David R Grant, Mark S Cattral, Paul D Greig, John Kachura, Sean P Cleary, Gonzalo Sapisochin
BACKGROUND: Liver resection (LR) and radiofrequency ablation (RFA) are curative-intent therapies for early stages of hepatocellular carcinoma (HCC). If HCC recurs, salvage liver transplant (SLT) may constitute a treatment option. OBJECTIVE: We aimed to compare the outcomes of patients transplanted for recurrent HCC after curative-intent therapies with those transplanted as initial therapy. METHODS: We conducted a matched-control (1:1) cohort study comparing patients with HCC treated with primary liver transplant (PLT) with SLT after HCC recurrence...
January 11, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29325292/-therapeutic-effect-of-transcatheter-arterial-chemoembolization-combined-with-ultrasound-guided-microwave-ablation-for-treatment-of-liver-cancer-in-special-sites
#7
A Liu, W Xu, H Xu, Y Wang, Y M Gu
Objective: To investigate the efficacy and clinical value of transcatheter arterial chemoembolization (TACE) combined with ultrasound-guided microwave ablation for the treatment of liver cancer in special sites. Methods: The patients with liver cancer in special sites (the liver cancer was adjacent to the gallbladder, dome of diaphragm, gastrointestinal tract, heart, great vessels, and portal vein, with the shortest distance from the tumor to the organ/lumen < 0.5 cm ) were enrolled as treatment group, and the patients with primary liver cancer in normal sites treated in our hospital during the same period were randomly enrolled as control group...
December 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/29323550/assessing-the-effect-of-weight-based-protocol-modifications-to-lower-dose-for-ct-guided-hepatic-and-renal-tumor-radiofrequency-ablations
#8
Supriya Gupta, Ronald S Arellano, Debra A Gervais, Dushyant V Sahani
OBJECTIVE: This study assessed radiation dose after CT-guided percutaneous radiofrequency ablations (RFAs) of hepatic and renal tumors and the effect of weight-based CT protocol modification for lowering overall dose in these procedures. MATERIALS AND METHODS: CT-guided RFA for renal and hepatic ablations performed from January 1, 2009, through December 31, 2009, were retrospectively reviewed (90 men and 48 women; age, 42-81 years). The radiation dose was recorded during each of the following steps: planning, performing, and postprocedure...
January 11, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29318905/multiparametric-mri-for-early-detection-of-diffuse-liver-disease-an-interview-with-david-breen
#9
David J Breen
David J Breen is Associate Professor of Radiology and previous Clinical Director of Radiology at University Hospital Southampton. His interests are in abdominal imaging and intervention, particularly of hepato-pancreato-biliary (HPB)and renal disease. He has a major interest in image-guided tumor ablation and improving outcomes from these procedures. He has previously served as Vice Chair of the NHS England Clinical Reference Group in Interventional Radiology and for the NIHR/NCRN Upper GI Clinical Studies Group...
January 10, 2018: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29318366/-surgical-innovations-in-treatment-of-metastatic-colorectal-cancer-complexity-of-metastatic-surgery-as-example-for-personalized-medicine
#10
REVIEW
C Hackl, S M Brunner, K M Schmidt, H J Schlitt
BACKGROUND: Extensive, bilobular and multifocal colorectal liver metastases (CLM) or metastases that are critically situated require an experienced surgeon and advanced surgical techniques to enable curative resection. OBJECTIVE: This article describes the toolbox of hepato-oncologic surgery including functional augmentation of liver segments by portal vein embolization/ligation, combinations of ablation and resection, two-stage resections and in situ split liver resection, also known as associating liver partition and portal vein ligation for staged hepatectomy (ALPPS)...
January 9, 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29316303/feasibility-study-of-modeling-liver-thermal-damage-using-minimally-invasive-optical-method-adequate-for-in-situ-measurement
#11
Jinzhe Zhao, Qi Zhao, Yingxu Jiang, Weitao Li, Yamin Yang, Zhiyu Qian, Jia Liu
Liver thermal ablation techniques have been widely used for the treatment of liver cancer. Kinetic model of damage propagation play an important role for ablation prediction and real-time efficacy assessment. However, practical methods for modeling liver thermal damage are rare. A minimally invasive optical method especially adequate for in situ liver thermal damage modeling is introduced in this paper. Porcine liver tissue was heated by water bath under different temperatures. During thermal treatment, diffuse reflectance spectrum (DRS) of liver was measured by optical fiber and used to deduce reduced scattering coefficient (μ's )...
January 9, 2018: Journal of Biophotonics
https://www.readbyqxmd.com/read/29308914/numerical-study-to-establish-relationship-between-coagulation-volume-and-target-tip-temperature-during-temperature-controlled-radiofrequency-ablation
#12
Sundeep Singh, Ramjee Repaka
The present study aims at proposing a relationship between the coagulation volume and the target tip temperature in different tissues (viz., liver, lung, kidney, and breast) during temperature-controlled radiofrequency ablation (RFA). A 20-min RFA has been modelled using commercially available monopolar multi-tine electrode subjected to different target tip temperatures that varied from 70°C to 100°C with an increment of 10°C. A closed-loop feedback proportional-integral-derivative (PID) controller has been employed within the finite element model to perform temperature-controlled RFA...
January 8, 2018: Electromagnetic Biology and Medicine
https://www.readbyqxmd.com/read/29308685/randomized-trial-of-preoperative-administration-of-oral-pregabalin-for-postoperative-analgesia-in-patients-scheduled-for-radiofrequency-ablation-of-focal-lesions-in-the-liver
#13
Amr Ahmed Magdy Abdelfattah, Fatma Rizk, Nehad Hawash, Amr Hanafy, Ferial El-Kalla, Sherief Abd-Elsalam
PURPOSE: The aim of this study was to evaluate the effect of preoperative pregabalin on postoperative analgesia in patients undergoing radiofrequency ablation (RFA) of hepatic focal lesions (HFLs). METHODS: This randomized controlled study was carried out on 70 adult patients for whom RFA was indicated to treat hepatocellular carcinoma. They were randomized into two groups: Group I: 35 patients who were given a placebo before the procedure and Group II: 35 patients who were given 150 mg of oral pregabalin one hour before the procedure...
January 7, 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29307784/ablating-both-fabp1-and-scp2-scpx-tko-induces-hepatic-phospholipid-and-cholesterol-accumulation-in-high-fat-fed-mice
#14
Sherrelle Milligan, Gregory G Martin, Danilo Landrock, Avery L McIntosh, John T Mackie, Friedhelm Schroeder, Ann B Kier
Although singly ablating Fabp1 or Scp2/Scpx genes may exacerbate the impact of high fat diet (HFD) on whole body phenotype and non-alcoholic fatty liver disease (NAFLD), concomitant upregulation of the non-ablated gene, preference for ad libitum fed HFD, and sex differences complicate interpretation. Therefore, these issues were addressed in male and female mice ablated in both genes (Fabp1/Scp2/Scpx null or TKO) and pair-fed HFD. Wild-type (WT) males gained more body weight as fat tissue mass (FTM) and exhibited higher hepatic lipid accumulation than WT females...
January 4, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29307467/hepatocellular-carcinoma
#15
REVIEW
Alejandro Forner, María Reig, Jordi Bruix
Hepatocellular carcinoma appears frequently in patients with cirrhosis. Surveillance by biannual ultrasound is recommended for such patients because it allows diagnosis at an early stage, when effective therapies are feasible. The best candidates for resection are patients with a solitary tumour and preserved liver function. Liver transplantation benefits patients who are not good candidates for surgical resection, and the best candidates are those within Milan criteria (solitary tumour ≤5 cm or up to three nodules ≤3 cm)...
January 4, 2018: Lancet
https://www.readbyqxmd.com/read/29307242/technology-of-irreversible-electroporation-and-review-of-its-clinical-data-on-liver-cancers
#16
Emil I Cohen, David Field, George Emmett Lynskey, Alexander Y Kim
Irreversible electroporation (IRE) has developed as a novel percutaneous ablative technique over the past decade and its utility in the treatment of primary and metastatic liver disease has progressed rapidly. Areas Covered: After discussing the principles behind the technology and the practical steps in its use, this article offers a detailed analysis of the recent published work that evaluates its safety and efficacy. The strengths and weaknesses of other ablative techniques, including radiofrequency ablation, microwave ablation and cryoablation, are discussed in detail...
January 8, 2018: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/29305395/ablation-of-endothelial-vegfr1-improves-metabolic-dysfunction-by-inducing-adipose-tissue-browning
#17
Takahiro Seki, Kayoko Hosaka, Carina Fischer, Sharon Lim, Patrik Andersson, Mitsuhiko Abe, Hideki Iwamoto, Yanyan Gao, Xinsheng Wang, Guo-Hua Fong, Yihai Cao
Angiogenesis plays an instrumental role in the modulation of adipose tissue mass and metabolism. Targeting adipose vasculature provides an outstanding opportunity for treatment of obesity and metabolic disorders. Here, we report the physiological functions of VEGFR1 in the modulation of adipose angiogenesis, obesity, and global metabolism. Pharmacological inhibition and genetic deletion of endothelial VEGFR1 augmented adipose angiogenesis and browning of subcutaneous white adipose tissue, leading to elevated thermogenesis...
January 5, 2018: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29303406/eus-dating-with-laser-ablation-against-the-caudate-lobe-or-left-liver-tumors-a-win-win-proposition
#18
Tian'an Jiang, Guo Tian, Haiwei Bao, Fen Chen, Zhuang Deng, Ju Li, Weilu Chai
Endoscopic ultrasound (EUS) have been not only a diagnostic tool, but also available in interventional therapy, which often previously needed surgical approaches to achieve. The study aimed to evaluate the effectiveness and safety of EUS-guided Nd:YAG laser ablation in unresectable tumors of the caudate lobe and left liver. We discussed ten cases of the caudate lobe and left liver tumors underwent laser ablation with EUS guidance. And we also have reviewed previous publication of EUS-guided thermal ablation for liver tumors in several decade years...
January 5, 2018: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/29301446/real-time-estimation-of-lesion-depth-and-control-of-radiofrequency-ablation-within-ex-vivo-animal-tissues-using-a-neural-network
#19
Yearnchee Curtis Wang, Terence Chee-Hung Chan, Alan Varteres Sahakian
BACKGROUND: Radiofrequency ablation (RFA), a method of inducing thermal ablation (cell death), is often used to destroy tumours or potentially cancerous tissue. Current techniques for RFA estimation (electrical impedance tomography, Nakagami ultrasound, etc.) require long compute times (≥ 2 s) and measurement devices other than the RFA device. This study aims to determine if a neural network (NN) can estimate ablation lesion depth for control of bipolar RFA using complex electrical impedance - since tissue electrical conductivity varies as a function of tissue temperature - in real time using only the RFA therapy device's electrodes...
January 4, 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29301352/stereotactic-body-radiation-therapy-in-the-management-of-upper-gi-malignancies
#20
REVIEW
Leila Tchelebi, Nicholas Zaorsky, Heath Mackley
The role of external beam radiation therapy (EBRT) in the management of upper gastrointestinal malignancies is constantly evolving. As radiation therapy techniques improve and are able to deliver more ablative doses of radiotherapy while sparing healthy tissue, radiation can be applied to a wider range of clinical scenarios. Stereotactic body radiation therapy (SBRT) allows a high dose of radiation to be delivered to a highly conformal treatment volume in a short amount of time. Another potential advantage of SBRT is its ability to increase tumor immunogenicity, while also having less of an immunosuppressive effect on the patient, as compared to conventionally fractionated radiation therapy...
January 3, 2018: Biomedicines
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