Fabio Del Bello, Valentina Bargelli, Carlo Cifani, Paola Gratteri, Carla Bazzicalupi, Eleonora Diamanti, Mario Giannella, Valerio Mammoli, Rosanna Matucci, Maria Vittoria Micioni Di Bonaventura, Alessandro Piergentili, Wilma Quaglia, Maria Pigini
Pharmacological studies have suggested that I1-imidazoline receptors are involved in the regulation of cardiovascular function and that selective I1-agonists, devoid of the side effects associated with the common hypotensive α2-adrenoreceptor agonists, might be considered as a second generation of centrally acting antihypertensives. Therefore, in the present study, inspired by the antihypertensive behavior of our selective I1-agonist 4, we designed, prepared, and studied the novel analogues 5-9. A selective I1-profile, associated with significant hemodinamic effects, was displayed by 5, 8, and 9...
May 14, 2015: ACS Medicinal Chemistry Letters