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Methamphetamine pups

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https://www.readbyqxmd.com/read/26739436/does-route-of-methamphetamine-exposure-during-pregnancy-have-an-impact-on-neonatal-development-and-behaviour-in-rat-offspring
#1
Kate McDonnell-Dowling, John P Kelly
Many preclinical studies have aimed to elucidate the effects of methamphetamine (MA) exposure during pregnancy on the offspring in recent years. However, the severity of effects on the neonate may be related to the subcutaneous (sc) route of administration of the drug that is often employed (88% of preclinical studies) and consequently the delivered dose that the foetus is exposed to. To date there is a paucity of comparative studies investigating different routes of administration for MA during pregnancy and it is not known how these different routes compare when it comes to neonatal outcome...
April 2016: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/26683901/prenatal-methamphetamine-differentially-alters-myocardial-sensitivity-to-ischemic-injury-in-male-and-female-adult-hearts
#2
Boyd R Rorabaugh, Sarah L Seeley, Albert D Bui, Lisanne Sprague, Manoranjan S D'Souza
Methamphetamine is one of the most common illicit drugs abused during pregnancy. The neurological effects of prenatal methamphetamine are well known. However, few studies have investigated the potential effects of prenatal methamphetamine on adult cardiovascular function. Previous work demonstrated that prenatal cocaine exposure increases sensitivity of the adult heart to ischemic injury. Methamphetamine and cocaine have different mechanisms of action, but both drugs exert their effects by increasing dopaminergic and adrenergic receptor stimulation...
February 15, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/26391019/the-consequences-of-prenatal-and-or-postnatal-methamphetamine-exposure-on-neonatal-development-and-behaviour-in-rat-offspring
#3
Kate McDonnell-Dowling, John P Kelly
Methamphetamine (MA) has become a popular drug of abuse in recent years not only in the general population but also amongst pregnant women. Although there is a growing body of preclinical investigations of MA exposure during pregnancy, there has been little investigation of the consequences of such exposure via the breast milk during the neonatal period. Therefore, the aim of this study was to determine the consequences of MA exposure during pregnancy and lactation on neurodevelopment and behaviour in the rat offspring...
December 2015: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/25669687/differences-in-maternal-behavior-and-development-of-their-pups-depend-on-the-time-of-methamphetamine-exposure-during-gestation-period
#4
M Malinová-Ševčíková, I Hrebíčková, E Macúchová, E Nová, M Pometlová, R Šlamberová
The present study examined the hypothesis that the extension of noxious effect of methamphetamine (MA) on maternal behavior and postnatal development on the pups may differ in dependence with time of application. Female rats were injected with MA (5 mg/kg) or saline during first (embryonic day (ED) 1-11) or second (ED 12-22) half of gestation. Our results demonstrated that MA exposure on ED 12-22 led to decreased birth weight and weight gained during lactation period relative to rats treated on ED 1-11. Both sexes treated prenatally with MA on ED 1-11 opened eyes earlier compared to animals treated on ED 12-22...
2014: Physiological Research
https://www.readbyqxmd.com/read/25535855/maternal-separation-increases-methamphetamine-induced-damage-in-the-striatum-in-male-but-not-female-rats
#5
Emily Hensleigh, Laurel M Pritchard
Methamphetamine abuse impacts the global economy through costs associated with drug enforcement, emergency room visits, and treatment. Previous research has demonstrated early life stress, such as childhood abuse, increases the likelihood of developing a substance abuse disorder. However, the effects of early life stress on neuronal damage induced by binge methamphetamine administration are unknown. We aimed to elucidate the effects of early life stress on methamphetamine induced dopamine damage in the striatum...
December 15, 2015: Behavioural Brain Research
https://www.readbyqxmd.com/read/24726427/sex-differences-in-methamphetamine-pharmacokinetics-in-adult-rats-and-its-transfer-to-pups-through-the-placental-membrane-and-breast-milk
#6
Lukas Rambousek, Petr Kacer, Kamila Syslova, Jakub Bumba, Vera Bubenikova-Valesova, Romana Slamberova
BACKGROUND: Methamphetamine (METH) abuse is a growing health problem worldwide, and METH use during pregnancy not only endangers the mother's health but also the developing fetus. To provide better insight into these risks, we performed the following experiments. METHOD: First, we investigated how sex influences the pharmacokinetics of METH and amphetamine (AMP) in male and female rats. Subsequently, we simulated chronic exposure of prenatal infants to METH abuse by investigating brain and plasma levels of METH and AMP in dams and pups...
June 1, 2014: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/24713150/the-effect-of-early-environmental-manipulation-on-locomotor-sensitivity-and-methamphetamine-conditioned-place-preference-reward
#7
E Hensleigh, L M Pritchard
Early life stress leads to several effects on neurological development, affecting health and well-being later in life. Instances of child abuse and neglect are associated with higher rates of depression, risk taking behavior, and an increased risk of drug abuse later in life. This study used repeated neonatal separation of rat pups as a model of early life stress. Rat pups were either handled and weighed as controls or separated for 180 min per day during postnatal days 2-8. In adulthood, male and female rats were tested for methamphetamine conditioned place preference reward and methamphetamine induced locomotor activity...
July 15, 2014: Behavioural Brain Research
https://www.readbyqxmd.com/read/23785337/the-effects-of-maternal-separation-on-adult-methamphetamine-self-administration-extinction-reinstatement-and-mecp2-immunoreactivity-in-the-nucleus-accumbens
#8
Candace R Lewis, Kelsey Staudinger, Lena Scheck, M Foster Olive
The maternal separation (MS) paradigm is an animal model of early life stress. Animals subjected to MS during the first 2 weeks of life display altered behavioral and neuroendocrinological stress responses as adults. MS also produces altered responsiveness to and self-administration (SA) of various drugs of abuse including cocaine, ethanol, and amphetamine. However, no studies have yet examined the effects of MS on methamphetamine (METH) SA. This study was performed to examine the effects of MS on the acquisition of METH SA, extinction, and reinstatement of METH-seeking behavior in adulthood...
2013: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/22815533/pharmacological-properties-and-procognitive-effects-of-abt-288-a-potent-and-selective-histamine-h3-receptor-antagonist
#9
Timothy A Esbenshade, Kaitlin E Browman, Thomas R Miller, Kathleen M Krueger, Victoria Komater-Roderwald, Min Zhang, Gerard B Fox, Lynne Rueter, Holly M Robb, Richard J Radek, Karla U Drescher, Thomas A Fey, R Scott Bitner, Kennan Marsh, James S Polakowski, Chen Zhao, Marlon D Cowart, Arthur A Hancock, James P Sullivan, Jorge D Brioni
Blockade of the histamine H(3) receptor (H(3)R) enhances central neurotransmitter release, making it an attractive target for the treatment of cognitive disorders. Here, we present in vitro and in vivo pharmacological profiles for the H(3)R antagonist 2-[4'-((3aR,6aR)-5-methyl-hexahydro-pyrrolo[3,4-b]pyrrol-1-yl)-biphenyl-4-yl]-2H-pyridazin-3-one (ABT-288). ABT-288 is a competitive antagonist with high affinity and selectivity for human and rat H(3)Rs (K(i) = 1.9 and 8.2 nM, respectively) that enhances the release of acetylcholine and dopamine in rat prefrontal cortex...
October 2012: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/22414962/altered-locomotor-and-stereotyped-responses-to-acute-methamphetamine-in-adolescent-maternally-separated-rats
#10
Laurel M Pritchard, Emily Hensleigh, Sarah Lynch
RATIONALE: Neonatal maternal separation (MS) has been used to model the effects of early life stress in rodents. MS alters behavioral responses to a variety of abused drugs, but few studies have examined its effects on methamphetamine sensitivity. OBJECTIVES: We sought to determine the effects of MS on locomotor and stereotyped responses to low-to-moderate doses of methamphetamine in male and female adolescent rats. METHODS: Male and female rat pups were subjected to 3 h per day of MS on postnatal days (PN) 2-14 or a brief handling control procedure during the same period...
September 2012: Psychopharmacology
https://www.readbyqxmd.com/read/21884713/sex-differences-in-anxiety-like-behavior-and-locomotor-activity-following-prenatal-and-postnatal-methamphetamine-exposure-in-adult-rats
#11
L Hrubá, B Schutová, R Šlamberová
The aim of the present study was to investigate the impact of prenatal and postnatal methamphetamine (MA) exposure on behavior and anxiety in adult male and female rats. Mothers were daily exposed to injection of MA (5 mg/kg) or saline (S): prior to impregnation and throughout gestation and lactation periods. On postnatal day 1, pups were cross-fostered so that each mother raised 6 saline-exposed pups and 6 MA-exposed pups. Based on the prenatal and postnatal exposure 4 experimental groups (S/S, S/MA, MA/S, MA/MA) were tested in the Open field (OF) and in the Elevated plus maze (EPM) in adulthood...
January 18, 2012: Physiology & Behavior
https://www.readbyqxmd.com/read/21861047/-effects-of-neonatal-isolation-stress-on-hyperlocomotion-of-complexin-ii-knockout-mouse
#12
Huan Yu, Yong Zhao, Wei He, Xing-Nuan Li, Yi-Chun Zhou, Li-Ping Liu
The aim of this study was to investigate the influence of neonatal isolation stress on hyperlocomotion in complexin II knockout mouse (Cplx2(-/-)). The mice were randomly divided into 4 groups: Cplx2(-/-) with stress, Cplx2(+/+) with stress, Cplx2(-/-) without stress and Cplx2(+/+) without stress. Isolation stress was employed on the pups of stress groups from the 2nd day after the postnatal to the 21st day. The PCR was used to determine the gene type and the hyperlocomotion test was employed to detect the change of animal behavior after methamphetamine or saline injection (i...
August 25, 2011: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/21067979/increased-seizure-susceptibility-induced-by-prenatal-methamphetamine-exposure-in-adult-female-rats-is-not-affected-by-early-postnatal-cross-fostering
#13
R Slamberová, L Hrubá, I Matějovská, K Bernášková, R Rokyta
Our previous studies repeatedly demonstrated that prenatal methamphetamine (MA) exposure alters seizure susceptibility in adult rats. Both the inhibitory GABA system and the excitatory NMDA system play a role in the effect of MA on epileptic seizures. On the basis of our previous behavioral results, the effect of cross-fostering on seizure susceptibility in adult female rats was examined in the present study. Bicuculline (GABA(A) receptor antagonist) and NMDA (NMDA receptor agonist) were used to induce seizures in adult female offspring exposed to MA in the prenatal and/or preweaning periods...
January 2011: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/20616555/neurotoxic-effects-of-mdma-ecstasy-on-the-developing-rodent-brain
#14
M Dzietko, M Sifringer, J Klaus, S Endesfelder, D Brait, H H Hansen, I Bendix, U Felderhoff-Mueser
The incidence of methamphetamine abuse is particularly high in adolescents and is a common problem among women of childbearing age, leading to an increasing number of children with prenatal exposure. MDMA (3,4-methylenedioxymethamphetamine, ecstasy) is an amphetamine-like stimulant and is known to induce apoptotic damage to fine serotonergic fibers in the adult rat brain. Little is known about toxic effects of MDMA and potential underlying molecular mechanisms in the developing brain. Here, we investigated whether MDMA exposure during the period of rapid brain growth causes neurodegeneration in the developing rat brain...
August 2010: Developmental Neuroscience
https://www.readbyqxmd.com/read/20599607/effect-of-cross-fostering-on-seizures-in-adult-male-offspring-of-methamphetamine-treated-rat-mothers
#15
R Slamberová, L Hrubá, K Bernásková, I Matejovská, R Rokyta
Stimulant drugs are often associated with increased seizure susceptibility. Inhibitory gamma-aminobutyric acid (GABA) and excitatory N-methyl-D-aspartate (NMDA) systems play a role in the effect of stimulants in the genesis of epileptic seizures. Our previous studies showed that prenatal methamphetamine (MA) exposure induced long-term changes in seizure susceptibility. The aim of the present study was to investigate the effect of cross-fostering on the prenatal and postnatal MA-exposed rats, respectively, on their seizures in adulthood...
October 2010: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/20188158/identification-of-post-generation-effect-of-3-4-methylenedioxymethamphetamine-on-the-mouse-brain-by-large-scale-gene-expression-analysis
#16
Jung Woo Eun, Seung Jun Kwack, Ji Heon Noh, Kwang Hwa Jung, Jeong Kyu Kim, Hyun Jin Bae, Hongjian Xie, Jae Chun Ryu, Young Min Ahn, Won Sang Park, Jung Young Lee, Gyu Seek Rhee, Suk Woo Nam
The compound 3,4-methylenedioxymethamphetamine (MDMA or ecstasy) is a synthetic, psychoactive drug chemically similar to the stimulant methamphetamine and the hallucinogen mescaline. Accumulated data has revealed potential toxic effects associated with MDMA on brain serotonin and dopamine neurons in animal models. However, the relevance of these adverse effects on prenatal exposure to this drug remains unknown. In this study, we demonstrated that prenatal (F0) exposure to MDMA caused permanent large-scale transcriptional changes in the brains of the offspring (F1), especially in the cerebral cortex, by gene expression profiling analysis...
May 19, 2010: Toxicology Letters
https://www.readbyqxmd.com/read/19937742/effect-of-prenatal-and-postnatal-methamphetamine-exposure-on-nociception-in-adult-female-rats
#17
Lenka Hrubá, Simon Vaculín, Romana Slamberová
The aim of the present study was to determine effects of methamphetamine (MA) exposure and cross-fostering on thermal nociceptive thresholds in different estrous phases in adult female rats. Rat mothers were exposed daily to injection of MA (5 mg/kg) or saline for 9 weeks: prior to impregnation, throughout gestation and lactation periods. Dams without any injections were used as an absolute control. On postnatal day 1, pups were cross-fostered so that each mother raised four pups of her own and eight pups from the mothers with the other two treatments...
January 2010: Developmental Psychobiology
https://www.readbyqxmd.com/read/19900489/effect-of-methamphetamine-exposure-and-cross-fostering-on-cognitive-function-in-adult-male-rats
#18
Lenka Hrubá, Barbora Schutová, Marie Pometlová, Richard Rokyta, Romana Slamberová
The aim of our study was to examine the effect of prenatal methamphetamine (MA) exposure and cross-fostering on cognitive functions of adult male rats tested in Morris water maze (MWM). Rat mothers were exposed daily to injection of MA (5mg/kg) or saline for 9 weeks: prior to impregnation, throughout gestation and lactation periods. Females without any injections were used as an absolute control. On postnatal day 1, pups were cross-fostered so that each mother raised 4 pups of her own and 8 pups from the mothers with the other two treatments...
March 17, 2010: Behavioural Brain Research
https://www.readbyqxmd.com/read/19655695/does-cross-fostering-modify-the-prenatal-effect-of-methamphetamine-on-learning-of-adult-male-rats
#19
L Hrubá, B Schutová, M Pometlová, R Slamberová
Our previous studies demonstrated that methamphetamine administered during gestation and lactation periods impairs maternal behavior, alters the functional development of rat pups and affects behavior in adulthood. The aim of our study was to investigate the effect of prenatal methamphetamine exposure and cross-fostering on learning tested in Morris water maze (MWM) in adult male rats. Mothers were daily exposed to injection of methamphetamine (MA) (5 mg/kg) or saline (S): prior to impregnation and throughout gestation and lactation periods...
2009: Prague Medical Report
https://www.readbyqxmd.com/read/19520673/vulnerability-to-methamphetamine-effects-and-the-relationship-to-drug-disposition-in-pregnant-rats-during-chronic-infusion
#20
Sarah J White, Elizabeth M Laurenzana, William Brooks Gentry, Howard P Hendrickson, David Keith Williams, Keith W Ward, Samuel Michael Owens
Chronic (+)-methamphetamine (METH) use during pregnancy increases the health risk for both mother and fetus. To provide insights into these risks, the relationship between changes in METH disposition and METH-induced pharmacological effects were studied in Sprague-Dawley rat dams and litters. Timed-pregnant rats (n = 5-6) were given saline or METH (5.6-17.8 mg/kg/day) by continuous sc infusion from gestational day (GD) 7 (before organogenesis) until GD21 (0-2 days before delivery). By GD11, all rats in the 17...
September 2009: Toxicological Sciences: An Official Journal of the Society of Toxicology
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