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Gastrointestinal ischemia

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https://www.readbyqxmd.com/read/30013889/neonatal-intrathoracic-gastric-volvulus-in-marfan-s-syndrome
#1
Javier Serradilla, Alba Bueno, Carlos De La Torre, Eduardo Alonso Gamarra, Martha Muñoz Romo, Francisco de Borja Nava Hurtado de Saracho, María Álvarez Barrial, Manuel Gomez Cervantes, Manuel Lopez Santamaria
We report a 12-day-old male who was admitted with vomiting because of an unusual early complication of Marfan's syndrome (MS): a sliding hiatal hernia. Initial ultrasound showed no stomach at its normal position and the chest X-ray presented an intrathoracic gas bubble with the nasogastric tube inside. An upper gastrointestinal contrast study confirmed the complete herniation of the stomach into the thorax. Via an exploratory laparotomy it was carefully reintroduced into the abdomen, following a hiatal reconstruction...
January 2018: European Journal of Pediatric Surgery Reports
https://www.readbyqxmd.com/read/29995617/a-spectrum-of-entities-that-may-mimic-abdominopelvic-abscesses-requiring-image-guided-drainage
#2
Lauren N Moomjian, Ryan D Clayton, Laura R Carucci
A variety of entities may mimic drainable abscesses. This can lead to misdiagnosis of these entities, unnecessary percutaneous placement of a pigtail drainage catheter, other complications, and delay in appropriate treatment of the patient. Types of entities that may mimic drainable abscesses include neoplasms (lymphoma, gallbladder cancer, gastrointestinal stromal tumor, ovarian cancer, mesenteric fibromatosis, ruptured mature cystic teratoma, recurrent malignancy in a surgical bed), ischemia/infarction (liquefactive infarction of the spleen, infarcted splenule), diverticula (calyceal, Meckel, and giant colonic diverticula), and congenital variants (obstructed duplicated collecting system)...
July 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29973094/intra-observer-and-inter-observer-reliability-of-visible-light-spectroscopy-during-upper-gastrointestinal-endoscopy
#3
Louisa J D van Dijk, Twan van der Wel, Desirée van Noord, Adriaan Moelker, Hence J Verhagen, Daan Nieboer, Ernst J Kuipers, Marco J Bruno
BACKGROUND: Visible Light Spectroscopy (VLS) performed during upper gastrointestinal endoscopy allows measuring mucosal oxygen saturation levels to determine gastrointestinal ischemia. We aimed to determine the observer variability of VLS. RESEARCH DESIGN AND METHODS: This is a single-center prospective study of 24 patients planned for usual care upper endoscopy. To test intra-observer variability, VLS-measurements were performed in duplicate by a single endoscopist in 12 patients...
July 4, 2018: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/29956615/roles-of-cyclooxygenase-prostaglandin-e2-and-ep-receptors-in-mucosal-protection-and-ulcer-healing-in-the-gastrointestinal-tract
#4
Koji Takeuchi, Kikuko Amagase
Endogenous prostaglandins (PGs), produced from arachidonic acid by the two isoforms of cyclooxygenase (COX), play a pivotal role in maintaining mucosal integrity by modulating various functions of the gastrointestinal (GI) tract, and PGE2 is most effective in these actions. The PGE2 receptor is classified into 4 specific G-protein coupled subtypes, EP1-EP4, and their distribution accounts for the multiple effects of this prostanoid. PGE2 prevents acid-reflux esophagitis and indomethacin-induced gastric lesions through EP1 receptors, while endogenous PGs protect the stomach against cold restraint stress mediated by mainly PGI2/IP receptors and partly EP4 receptors...
June 28, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29952954/the-outcomes-and-prognostic-factors-of-the-patients-with-unplanned-intensive-care-unit-readmissions
#5
Wei-Ting Lin, Wan-Ling Chen, Chien-Ming Chao, Chih-Cheng Lai
This retrospective cohort study investigated the outcomes of patients with unplanned intensive care unit (ICU) readmission.All of the patients readmitted to ICU within 48 hours between 2010 and 2016 were enrolled.A total of 99 patients early readmitted to ICU were identified and their mean age of the patients was 68.8 ± 14.8 years. Respiratory failure was the most common cause of ICU readmission (n = 48, 48.5%), followed by acute myocardial ischemia or worsening heart failure (n = 25, 25.3%), sepsis (n = 22, 22...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29950267/enteroenteric-fistulae-in-acute-bowel-ischemia
#6
Muhammad Salman Khan, Inamullah Khan, Amir Humza, Y Bashir Hadi, Zeeshan Haider
Gastrointestinal fistulae are classified as enteroenteric or enterocutaneous. Most gastrointestinal fistulae are formed after surgical procedures for inflammatory bowel disease or malignancy. For spontaneous enteroenteric fistulae, ischemia has been reported as a possible etiology. We report two cases of spontaneous enteroenteric fistulae arising after bowel ischemia; a 38-year male with a 10-day history of severe abdominal pain with fever and vomiting, and a 22-year female with a one-week history of abdominal pain and diarrhea...
July 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29950058/-analysis-of-protective-effects-of-chaihu-jia-longgu-muli-tang-against-ischemic-stroke-by-combining-traditional-chinese-medicine-pathogenesis-and-efficacy-with-modern-pathology-and-pharmacology
#7
Peng-Qian Wang, Yin Wu, Miao Zhang, Hai-Ru Huo, Xin-Ling Du, Feng Sui
Chaihu Jia Longgu Muli Tang is a classical Chinese formulas treating Shaoyang syndrome complicated with Yangming syndrome according to Treatise on Febrile Diseases. This formula is used in mental disorder, nervous system, gynecologic, andrologic, and cardiovascular disease. However, its therapeutic effect on ischemia stroke and its mechanism is far from clear. In clinical practice, we have found that this formula is effective in treating ischemic stroke, which can shorten the course of the disease and reduce recurrence...
June 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29943197/combined-resection-of-the-transpancreatic-common-hepatic-artery-preserving-the-gastric-arterial-arcade-without-arterial-reconstruction-in-hepatopancreatoduodenectomy-a-case-report
#8
Takashi Miyata, Yusuke Yamamoto, Teiichi Sugiura, Yukiyasu Okamura, Takaaki Ito, Ryo Ashida, Sunao Uemura, Yoshiyasu Kato, Katsuhisa Ohgi, Atsushi Kohga, Tsuneyuki Uchida, Shusei Sano, Katsuhiko Uesaka
BACKGROUND: Surgeons sometimes must plan pancreatoduodenectomy (PD) for patients with a variant common hepatic artery (CHA) branching from the superior mesenteric artery (SMA) penetrating the pancreatic parenchyma, known as a transpancreatic CHA (tp-CHA). CASE PRESENTATION: A 67-year-old man was admitted to our hospital because of liver dysfunction. A duodenal tumor was identified by gastrointestinal endoscopy, and a biopsy revealed a neuroendocrine tumor. Computed tomography showed multiple metastases in the left three sections of the liver...
June 26, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29942902/digital-gangrene-and-pneumatosis-intestinalis-associated-with-calciphylaxis
#9
Qingwen Kawaji, Erik Brian Eller, Jerry Yee, Judith C Lin
Reports of calciphylaxis or calcific uremic arteriolopathy associated with acral and gastrointestinal involvement are rare. We describe a 36-year-old white woman with end-stage renal disease on hemodialysis after failed kidney and pancreas transplantation who developed dry gangrene of bilateral digits, osteomyelitis, and small bowel ischemia within several months of each presentation. She had multiple débridements of a septic right ankle. Computed tomography angiography showed severe vascular calcification and pneumatosis intestinalis...
June 2018: Journal of vascular surgery cases and innovative techniques
https://www.readbyqxmd.com/read/29942212/management-of-diverticular-disease-in-the-setting-of-other-colorectal-pathology-data-on-simultaneous-issues-in-segmental-colitis-inflammatory-bowel-disease-cancer-and-complications
#10
REVIEW
Nasrin Ghalyaie
Diverticulosis of the colon is a very common anatomical condition. In the Western world, it affects more than 70% of over 65 years old population and represents the fifth most important gastrointestinal disease in terms of health care costs in Western countries. The diagnosis of diverticular disease and diverticulitis can be challenging. Often, there is overlap with other colonic pathologies, such as segmental colitis, ischemia, inflammatory bowel disease, cancer, or infectious colitis. Management of diverticular disease in these settings might be different...
July 2018: Clinics in Colon and Rectal Surgery
https://www.readbyqxmd.com/read/29932372/fibrin-patch-influences-the-expression-of-hypoxia-inducible-factor-1%C3%AE-and-nuclear-factor-%C3%AE%C2%BAbp65-factors-on-ischemic-intestinal-anastomosis
#11
Carlos García-Vásquez, María J Fernández-Aceñero, Soledad García Gómez-Heras, Carlos Pastor
The intestinal anastomotic failure is one of the most severe complications in gastrointestinal surgery. Despite the great surgical improvements during the last decade, anastomotic leak rates remain practically the same, with a dramatically high grade of morbidity for patients. Leakages are usually the final consequence of ischemia in the anastomosis, leading to tissue hypoxia. In response to hypoxia, the cell orchestrates a variety of coordinated responses in order to restore oxygen homeostasis. The molecular mechanism of hypoxia sensitivity involves oxygen sensing hydroxylases, prolyl-hydroxylases, orchestrating two main transcription factors related to induction of inflammation and angiogenesis, namely nuclear factor-κB and hypoxia-inducible factors...
June 2018: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29904492/reduced-iodinated-contrast-media-for-abdominal-imaging-by-dual-layer-spectral-detector-computed-tomography-for-patients-with-kidney-disease
#12
Hirokazu Saito, Kana Noda, Koji Ogasawara, Shutaro Atsuji, Hiroko Takaoka, Hiroo Kajihara, Jiro Nasu, Mitsuhiko Kitaoka, Shoji Morishita, Ikuo Matsushita, Kazuhiro Katahira
Contrast-enhanced computed tomography using iodinated contrast media is useful for diagnosis of gastrointestinal diseases. However, contrast-induced nephropathy remains problematic for kidney diseases patients. Although current guidelines recommended the use of a minimal dose of contrast media necessary to obtain adequate images for diagnosis, obtaining adequate images with sufficient contrast enhancement is difficult with conventional computed tomography using reduced contrast media. Dual-layer spectral detector computed tomography enables the simultaneous acquisition of low- and high-energy data and the reconstruction of virtual monochromatic images ranging from 40 to 200 keV, retrospectively...
April 2018: Radiology Case Reports
https://www.readbyqxmd.com/read/29880362/living-donor-liver-transplantation-in-hepatitis-c-virus-era-a-report-of-500-consecutive-cases-in-a-single-center
#13
M A Wahab, A Shehta, M Elshoubary, A M Yassen, M Elmorshedi, T Salah, A M Sultan, O Fathy, W R Elsarraf, U Shiha, K Zalata, A N Elghawalby, M Eldesoky, A Monier, R Said, A M Elsabagh, M Ali, A Kandeel, U Abdalla, M Aboelella, M Elsadany, E E Abdel-Khalek, A Marwan, F M ElMorsi, R Adly
BACKGROUND: Living donor liver transplantation (LDLT) is considered a safe alternative to deceased donor liver transplantation (DDLT). In Egypt, DDLT program is still awaited, making LDLT the only hope for patients with end-stage liver disease, mainly due to chronic hepatitis C virus (HCV) infection. The current study is conducted to evaluate our experience of LDLT and discuss the lessons learned from 500 consecutive cases in HCV area. METHODS: We reviewed the data of patients who underwent LDLT at Gastrointestinal Surgery Center, Mansoura University during the period between May 2004 and March 2017...
June 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29866817/von-willebrand-factor-regulation-of-blood-vessel-formation
#14
REVIEW
Anna M Randi, Koval E Smith, Giancarlo Castaman
Several important physiological processes, from permeability to inflammation to hemostasis, take place at the vessel wall and are regulated by endothelial cells (ECs). Thus, proteins that have been identified as regulators of one process are increasingly found to be involved in other vascular functions. Such is the case for von Willebrand factor (VWF), a large glycoprotein best known for its critical role in hemostasis. In vitro and in vivo studies have shown that lack of VWF causes enhanced vascularization, both constitutively and following ischemia...
July 12, 2018: Blood
https://www.readbyqxmd.com/read/29863654/intestinal-stem-cell-isolation-and-culture-in-a-porcine-model-of-segmental-small-intestinal-ischemia
#15
Amy Stieler Stewart, John M Freund, Anthony T Blikslager, Liara M Gonzalez
Intestinal ischemia remains a major cause of morbidity and mortality in human and veterinary patients. Many disease processes result in intestinal ischemia, when the blood supply and therefore oxygen is decreased to the intestine. This leads to intestinal barrier loss and damage to the underlying tissue. Intestinal stem cells reside at the base of the crypts of Lieberkühn and are responsible for intestinal renewal during homeostasis and following injury. Ex vivo cell culture techniques have allowed for the successful study of epithelial stem cell interactions by establishing culture conditions that support the growth of three-dimensional epithelial organ-like systems (termed "enteroids" and "colonoids" from the small and large intestine, respectively)...
May 18, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29849356/dead-legs-a-case-of-bilateral-leg-paralysis
#16
Faith Quenzer, Joel Stillings, Jacqueline Le
Aortoiliac occlusive disease (AOD) is a rare presentation of thrombosis of the abdominal aorta. Also known as Leriche syndrome, its classic description entails claudication of the buttocks, thighs, and calves, absent femoral pulses, and impotence. AOD risk factors include smoking, hypertension, hyperlipidemia, diabetes, chronic renal insufficiency, and hypercoagulopathy. Ischemic complications of gastrointestinal malperfusion, renal infarction, and paralysis secondary to spinal cord ischemia are also noted...
November 2017: Clinical practice and cases in emergency medicine
https://www.readbyqxmd.com/read/29805081/bilateral-caudate-nucleus-infarctions-following-upper-gastrointestinal-bleeding
#17
Kensuke Daida, Nobukazu Miyamoto, Hiromi Takagi, Yuji Ueno, Kazuo Yamashiro, Ryota Tanaka, Nobutaka Hattori
A 75-year-old woman presented with consciousness disturbance accompanied by hematemesis. Brain imaging revealed ischemia in the bilateral caudate nuclei and right cerebral watershed area due to stenosis of the right anterior cerebral artery (ACA) and bilateral internal carotid arteries (ICA), and hypoperfusion in the right caudate nucleus. The patient's only symptom was abulia, which gradually resolved. Further brain scans showed that the ICA stenosis had improved, although the right ACA stenosis persisted...
May 24, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29748820/trans-arterial-embolization-of-non-variceal-upper-gastrointestinal-bleeding-is-the-use-of-ethylene-vinyl-alcohol-copolymer-as-safe-as-coils
#18
Marcello Andrea Tipaldi, Gianluigi Orgera, Miltiadis Krokidis, Alberto Rebonato, Daniele Maiettini, Simone Vagnarelli, Cesare Ambrogi, Michele Rossi
PURPOSE: The safety of liquid embolics over the conventional coils for the treatment of non-variceal upper gastrointestinal bleeding (UGIB) approach is still unclear. Purpose of this study is to assess the safety of ethylene-vinyl alcohol copolymer (EVOH 6%) over coils in the treatment of UGIB. MATERIALS AND METHODS: All the upper gastrointestinal tract embolization procedures performed in a single center in a 6-year period were reviewed. Patients embolised with coils (Group A) versus those embolised with EVOH 6% (Group B) were compared...
May 10, 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29743484/released-mitochondrial-dna-following-intestinal-ischemia-reperfusion-induces-the-inflammatory-response-and-gut-barrier-dysfunction
#19
Qiongyuan Hu, Huajian Ren, Jianan Ren, Qinjie Liu, Jie Wu, Xiuwen Wu, Guanwei Li, Gefei Wang, Guosheng Gu, Kun Guo, Zhiwu Hong, Song Liu, Jieshou Li
Ischemia-reperfusion (I/R) injury is a challenging clinical problem, especially injuries involving the gastrointestinal tract. Mitochondrial DNA (mtDNA) is released upon cell death and stress, and can induce the inflammatory response. We aimed to investigate the role of mtDNA in the pathogenesis of intestinal I/R. Intestinal I/R model was established with clamping of the superior mesenteric artery, and IEC-6 cells were incubated under hypoxia/reoxygenation (H/R) conditions to simulate I/R injury. Using in vitro models, H/R up-regulated oxidative stress, disrupted mitochondrial activity and the mitochondrial membrane potential, induced apoptosis and elevated the mtDNA levels in the supernatant of intestinal epithelial cells, and the co-culture of mtDNA with human primary dendritic cells significantly elevated TLR9-MyD88 expression and enhanced the production of inflammatory cytokines and chemokines...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29737512/histomorphometric-analysis-with-a-proposed-tissue-lesion-index-in-ischemia-reperfusion-induced-gastric-mucosa-damage
#20
Eduardo Peña-Mercado, Mario Garcia-Lorenzana, Nohra E Beltran
Damage to the gastrointestinal mucosa caused by ischemia - reperfusion is a significant clinical problem associated with various physiopathological conditions. Our group has conducted various studies in patients in critical conditions and in animal models to identify early damage to the gastric mucosa under ischemia using impedance spectroscopy. It is important to perform a quantitative histopathological analysis which can be linked to changes in impedance of the gastric mucosa under conditions of ischemia and I/R...
May 8, 2018: Histology and Histopathology
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