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https://www.readbyqxmd.com/read/29169144/targeting-the-wnt-beta-catenin-pathway-in-cancer-update-on-effectors-and-inhibitors
#1
REVIEW
Nithya Krishnamurthy, Razelle Kurzrock
The Wnt/beta-catenin pathway is a family of proteins that is implicated in many vital cellular functions like stem cell regeneration and organogenesis. Several intra-cellular signal transduction pathways are induced by Wnt, notably the Wnt/beta-catenin dependent pathway or canonical pathway and the non-canonical or beta-catenin-independent pathway, the latter includes the Wnt/Ca2+ and Planar Cell Polarity pathway (PCP). Wnt activation occurs at the intestinal crypt floor, and is critical to optimal maintenance of stem cells...
November 13, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29168886/phytochemical-profiling-of-anti-inflammatory-lavandula-extracts-via-rp-hplc-dad-qtof-ms-and-ms-ms-assessment-of-their-qualitative-and-quantitative-differences
#2
María Del Mar Contreras, Francesca Algieri, Alba Rodriguez-Nogales, Julio Gálvez, Antonio Segura-Carretero
As for other aromatic plants, there are many analytical methods for the determination of volatile compounds in lavender essential oils. Alternatively, in this study RP-HPLC-DAD-QTOF-MS was used for the profiling of the phytochemical constituents of hydromethanolic extracts of L. stoechas and L. dentata, which were obtained by pressurized liquid extraction. The spectrometric data revealed complex profiles constituted of a wide range of polar and semi-polar phytochemicals, mainly, phenolic compounds (68). Most phenolic compounds (55) have not been previously reported in Lavandula; such is the case of caffeic acid-based oligomers...
November 23, 2017: Electrophoresis
https://www.readbyqxmd.com/read/29168868/structural-elucidation-and-immunostimulatory-activity-of-a-new-polysaccharide-from-cordyceps-militaris
#3
Sixue Bi, Yongshuai Jing, Qinqin Zhou, Xianjing Hu, Jianhua Zhu, Zhongyi Guo, Liyan Song, Rongmin Yu
A new polysaccharide (CMPB90-1) was isolated from cultured Cordyceps militaris by alkaline extraction. The chemical structure of CMPB90-1 was determined by analysis of physicochemical and spectral data. The backbone of CMPB90-1 is composed of (1→6)-linked α-d-glucopyranosyl and (1→3)-linked α-d-glucopyranosyl residues, with branching at O-6, which consists of (1→4)-linked β-d-mannopyranosyl and (1→6)-linked α-d-glucopyranosyl residues, respectively. β-d-Galactopyranosyl residues is the terminal unit...
November 23, 2017: Food & Function
https://www.readbyqxmd.com/read/29168735/a-polar-initial-alignment-algorithm-for-unmanned-underwater-vehicles
#4
Zheping Yan, Lu Wang, Tongda Wang, Honghan Zhang, Xun Zhang, Xiangling Liu
Due to its highly autonomy, the strapdown inertial navigation system (SINS) is widely used in unmanned underwater vehicles (UUV) navigation. Initial alignment is crucial because the initial alignment results will be used as the initial SINS value, which might affect the subsequent SINS results. Due to the rapid convergence of Earth meridians, there is a calculation overflow in conventional initial alignment algorithms, making conventional initial algorithms are invalid for polar UUV navigation. To overcome these problems, a polar initial alignment algorithm for UUV is proposed in this paper, which consists of coarse and fine alignment algorithms...
November 23, 2017: Sensors
https://www.readbyqxmd.com/read/29168728/interference-of-htlv-1-tax-protein-with-cell-polarity-regulators-defining-the-subcellular-localization-of-the-tax-dlg1-interaction
#5
Federico Marziali, Marina Bugnon Valdano, Clarisse Brunet Avalos, Lucía Moriena, Ana Laura Cavatorta, Daniela Gardiol
Human T cell leukemia virus (HTLV)-1 Tax (Tax) protein is very important in viral replication and cell transformation. Tax localizes in the nucleus and cytoplasm in association with organelles. Some activities of Tax depend on interactions with PDZ (PSD-95/Discs Large/Z0-1) domain-containing proteins such as Discs large protein 1 (DLG1) which is involved in cell polarity and proliferation. The DLG1 interaction results in a cytoplasmic co-localization pattern resembling vesicular aggregates, the nature of which is still unknown...
November 23, 2017: Viruses
https://www.readbyqxmd.com/read/29168620/simple-organic-salts-having-naphthalenediimide-ndi-core-displaying-multi-functional-properties-gelation-anti-cancer-and-semiconducting-properties
#6
Parthasarathi Dastidar, Rumana Parveen, Nabasmita Maity
Following a supramolecular synthon rationale a dicarboxylic acid derivative having naphthalenediimide (NDI) core namely bis-N-carboxymethyl naphthalenediimide (NDI-A) was reacted with n-alkyl amines having varying alkyl chain length to generate a new series of primary ammonium dicarboxylate (PAD) salts. Majority of the salts (~85%) were found to gel various polar solvents. The gels were characterized by dynamic rheology and high resolution electron microscopy. Single crystal and powder X-ray diffraction were employed to study the supramolecular synthon present in one of the gelator salts namely S8...
November 23, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29168554/relation-between-denaturation-time-measured-by-optical-coherence-reflectometry-and-thermal-lesion-depth-during-radiofrequency-cardiac-ablation-feasibility-numerical-study
#7
Ana González-Suárez, David Herranz, Enrique Berjano, Jose L Rubio-Guivernau, Eduardo Margallo-Balbás
BACKGROUND/OBJECTIVE: Radiofrequency (RF) catheter ablation is a minimally invasive medical procedure used to thermally destroy the focus of cardiac arrhythmias. Novel optical techniques are now being integrated into RF catheters in order to detect the changes in tissue properties. Loss of birefringence due to fiber denaturation at around 70°C is related to changes in accumulated phase retardation and can be measured by polarization-sensitive optical coherence reflectometry (PS-OCR)...
November 23, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29168481/direct-mapping-of-the-angle-dependent-barrier-to-reaction-for-cl%C3%A2-%C3%A2-chd3-using-polarized-scattering-data
#8
Huilin Pan, Fengyan Wang, Gábor Czakó, Kopin Liu
The transition state, which gates and modulates reactive flux, serves as the central concept in our understanding of activated reactions. The barrier height of the transition state can be estimated from the activation energy taken from thermal kinetics data or from the energetic threshold in the measured excitation function (the dependence of reaction cross-sections on initial collision energies). However, another critical and equally important property, the angle-dependent barrier to reaction, has not yet been amenable to experimental determination until now...
December 2017: Nature Chemistry
https://www.readbyqxmd.com/read/29168318/validation-of-x-ray-wavefunction-refinement
#9
Magdalena Woińska, Dylan Jayatilaka, Birger Dittrich, Ralf Flaig, Peter Luger, Krzysztof Woźniak, Paulina M Dominiak, Simon Grabowsky
In this work, the quality of the electron density in crystals reconstructed by the multipolar model (MM) and by X-ray wavefunction refinement (XWR) is tested on a set of high-resolution X-ray diffraction data sets of four amino acids and six tripeptides. It results in the first thorough validation of XWR. Agreement statistics, figures of merit, residual- and deformation-density maps, as well as atomic displacement parameters are used to measure the quality of the reconstruction relative to the measured structure factors...
November 23, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/29167836/optical-spin-transfer-and-spin-orbit-torques-in-thin-film-ferromagnets
#10
Junwen Li, Paul M Haney
We study the optically induced torques in thin film ferromagnetic layers under excitation by circularly polarized light. We study cases both with and without Rashba spin-orbit coupling using a 4-band model. In the absence of Rashba spin-orbit coupling, we derive an analytic expression for the optical torques, revealing the conditions under which the torque is mostly derived from optical spin transfer torque (i.e. when the torque is along the direction of optical angular momentum), versus when the torque is derived from the inverse Faraday effect (i...
August 2017: Physical Review. B
https://www.readbyqxmd.com/read/29167673/inhibition-of-allograft-inflammatory-factor-1-in-dendritic-cells-restrains-cd4-t-cell-effector-responses-and-induces-cd25-foxp3-t-regulatory-subsets
#11
Diana M Elizondo, Temesgen E Andargie, Dazhi Yang, Apollo D Kacsinta, Michael W Lipscomb
Allograft inflammatory factor-1 (AIF1) is a cytoplasmic scaffold protein shown to influence immune responses in macrophages and microglial cells. The protein contains Ca(2+) binding EF-hand and PDZ interaction domains important for mediating intracellular signaling complexes. This study now reports that AIF1 is expressed in CD11c(+) dendritic cells (DC) and silencing of expression restrains induction of antigen-specific CD4(+) T cell effector responses. AIF1 knockdown in murine DC resulted in impaired T cell proliferation and skewed polarization away from T helper type 1 and 17 fates...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29167593/establishing-brdf-calibration-capabilities-through-shortwave-infrared
#12
Georgi T Georgiev, James J Butler, Kurt Thome, Catherine Cooksey, Leibo Ding
Satellite instruments operating in the reflective solar wavelength region require accurate and precise determination of the Bidirectional Reflectance Distribution Functions (BRDFs) of the laboratory and flight diffusers used in their pre-flight and on-orbit calibrations. This paper advances that initial work and presents a comparison of spectral Bidirectional Reflectance Distribution Function (BRDF) and Directional Hemispherical Reflectance (DHR) of Spectralon, a common material for laboratory and on-orbit flight diffusers...
2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/29167580/pyridoxamine-improves-survival-and-limits-cardiac-dysfunction-after-mi
#13
Dorien Deluyker, Vesselina Ferferieva, Ronald B Driesen, Maxim Verboven, Ivo Lambrichts, Virginie Bito
Advanced glycation end products (AGEs) play a key role in the progression of heart failure. Whether treatments limiting AGEs formation would prevent adverse left ventricular remodeling after myocardial infarction (MI) remain unknown. We investigated whether pyridoxamine (PM) could limit adverse cardiac outcome in MI. Rats were divided into MI, MI + PM and Sham. Echocardiography and hemodynamic parameters were used to assess cardiac function 8 weeks post-surgery. Total interstitial collagen, collagen I and collagen III were quantified using Sirius Red and polarized light microscopy...
November 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29167513/band-gap-engineering-of-in-ga-n-gan-short-period-superlattices
#14
I Gorczyca, T Suski, P Strak, G Staszczak, N E Christensen
Discussion of band gap behavior based on first principles calculations of the electronic band structures for several InN/GaN superlattices (SLs) (free-standing and pseudomorphic) grown along different directions (polar and nonpolar) is presented. Taking into account the dependence on internal strain and lattice geometry mainly two factors influence the dependence of the band gap, E g on the layer thickness: the internal electric field and the hyb wells) is more important. We also consider mIn ridization of well and barrier wave functions...
November 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29167496/temporal-depolarization-of-mitochondria-during-m-phase
#15
Kotoe Hirusaki, Kaho Yokoyama, Kyunghak Cho, Yoshihiro Ohta
Mitochondrial activity in cells must be tightly controlled in response to changes in intracellular circumstances. Despite drastic changes in intracellular conditions and mitochondrial morphology, it is not clear how mitochondrial activity is controlled during M phase of the cell cycle. Here, we show that mitochondrial activity is drastically changed during M phase. Mitochondrial membrane potential changed during M phase progression. Mitochondria were polarized until metaphase to the same extent as mitochondria in interphase cells, but were depolarized at around telophase and cytokinesis...
November 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29167480/dynamical-binding-modes-determine-agonistic-and-antagonistic-ligand-effects-in-the-prostate-specific-g-protein-coupled-receptor-psgr
#16
Steffen Wolf, Nikolina Jovancevic, Lian Gelis, Sebastian Pietsch, Hanns Hatt, Klaus Gerwert
We analysed the ligand-based activation mechanism of the prostate-specific G-protein coupled receptor (PSGR), which is an olfactory receptor that mediates cellular growth in prostate cancer cells. Furthermore, it is an olfactory receptor with a known chemically near identic antagonist/agonist pair, α- and β-ionone. Using a combined theoretical and experimental approach, we propose that this receptor is activated by a ligand-induced rearrangement of a protein-internal hydrogen bond network. Surprisingly, this rearrangement is not induced by interaction of the ligand with the network, but by dynamic van der Waals contacts of the ligand with the involved amino acid side chains, altering their conformations and intraprotein connectivity...
November 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29167477/heterolytic-splitting-of-molecular-hydrogen-by-frustrated-and-classical-lewis-pairs-a-unified-reactivity-concept
#17
Gabriella Skara, Freija De Vleeschouwer, Paul Geerlings, Frank De Proft, Balazs Pinter
Using a set of state-of-the-art quantum chemical techniques we scrutinized the characteristically different reactivity of frustrated and classical Lewis pairs towards molecular hydrogen. The mechanisms and reaction profiles computed for the H2 splitting reaction of various Lewis pairs are in good agreement with the experimentally observed feasibility of H2 activation. More importantly, the analysis of activation parameters unambiguously revealed the existence of two reaction pathways through a low-energy and a high-energy transition state...
November 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29167432/simultaneous-quarter-wave-plate-and-half-mirror-operation-through-a-highly-flexible-single-layer-anisotropic-metasurface
#18
M Ismail Khan, Farooq A Tahir
A highly flexible single-layer metasurface manifesting quarter-wave plate as well as half-mirror (1:1 beam-splitter) operation in the microwave frequency regime is being presented in this research. The designed metasurface reflects half power of the impinging linearly polarized electromagnetic wave as circularly polarized wave while the remaining half power is transmitted as circularly polarized wave at resonance frequency. Similarly, a circularly polarized incident wave is reflected and transmitted as linearly polarized wave with equal half powers...
November 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29167383/c-terminal-src-kinase-csk-regulates-the-tricellular-junction-protein-gliotactin-independent-of-src
#19
G D N Gayathri Samarasekera, Vanessa Jane Auld
Tricellular junctions (TCJs) are uniquely placed permeability barriers formed at the corners of polarized epithelia where tight junctions (TJ) in vertebrates or septate junctions (SJ) in invertebrates from three cells converge. Gliotactin is a Drosophila TCJ protein and loss of Gliotactin results in SJ and TCJ breakdown, and permeability barrier loss. When overexpressed, Gliotactin spreads away from the TCJs resulting in disrupted epithelial architecture including over-proliferation, cell delamination and migration...
November 22, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/29167320/mapks-influence-pollen-tube-growth-by-controlling-the-formation-of-phosphatidylinositol-4-5-bisphosphate-in-an-apical-plasma-membrane-domain
#20
Franziska Hempel, Irene Stenzel, Mareike Heilmann, Praveen Krishnamoorthy, Wilhelm Menzel, Ralph Golbik, Stefan Helm, Dirk Dobritzsch, Sacha Baginsky, Justin Lee, Wolfgang Hoehenwarter, Ingo Heilmann
An apical plasma membrane domain enriched in the regulatory phospholipid phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) is critical for polar tip growth of pollen tubes. How the biosynthesis of PtdIns(4,5)P2 by phosphatidylinositol 4-phosphate 5-kinases (PI4P 5-kinases) is controlled by upstream signaling is currently unknown. The pollen-expressed PI4P 5-kinase PIP5K6 is required for clathrin-mediated endocytosis and polar tip growth in pollen tubes. Here, we identify PIP5K6 as a target of the pollen-expressed mitogen-activated protein kinase MPK6 and characterize the regulatory effects...
November 22, 2017: Plant Cell
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