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https://www.readbyqxmd.com/read/29141219/preventive-inhibition-of-liver-tumorigenesis-by-systemic-activation-of-innate-immune-functions
#1
Jin Lee, Rui Liao, Gaowei Wang, Bi-Huei Yang, Xiaolin Luo, Nissi M Varki, Shuang-Jian Qiu, Bing Ren, Wenxian Fu, Gen-Sheng Feng
Liver cancer has become the second most deadly malignant disease, with no efficient targeted or immune therapeutic agents available yet. While dissecting the roles of cytoplasmic signaling molecules in hepatocarcinogenesis using an inducible mouse gene targeting system, Mx1-cre, we identified a potent liver tumor-inhibitory effect of synthetic double-stranded RNA (dsRNA), polyinosinic-polycytidylic acid (pIC), an inducer of the Mx1-cre system. Injection of pIC at the pre-cancer stage robustly suppressed liver tumorigenesis either induced by chemical carcinogens or by Pten loss and associated hepatosteatosis...
November 14, 2017: Cell Reports
https://www.readbyqxmd.com/read/29141156/plasmid-azobr_p1-borne-fabg-gene-for-putative-3-oxoacyl-acyl-carrier-protein-reductase-is-essential-for-proper-assembly-and-work-of-the-dual-flagellar-system-in-the-alphaproteobacterium-azospirillum-brasilense-sp245
#2
Yulia A Filip'echeva, Andrei V Shelud'ko, Alexei G Prilipov, Gennady L Burygin, Elizaveta M Telesheva, Stella S Yevstigneyeva, Marina P Chernyshova, Lilia P Petrova, Elena I Katsy
Azospirillum brasilense can swim and swarm owing to the activity of a constitutive polar flagellum (Fla) and inducible lateral flagella (Laf), respectively. Experimental data on the regulation of the Fla and Laf assembly in azospirilla are scarce. Here, the coding sequence (CDS) AZOBR_p1160043 (fabG1) for a putative 3-oxoacyl-[acyl-carrier protein (ACP)] reductase was found essential for the construction of both types of flagella. In an immotile leaky Fla- Laf- fabG1::Omegon-Km mutant, Sp245.1610, defects in flagellation and motility were fully complemented by expressing the CDS AZOBR_p1160043 from plasmid pRK415...
November 15, 2017: Canadian Journal of Microbiology
https://www.readbyqxmd.com/read/29141150/all-dielectric-dual-color-pixel-with-subwavelength-resolution
#3
Yusuke Nagasaki, Masafumi Suzuki, Junichi Takahara
An all-dielectric optical antenna supporting Mie resonances enables light confinement below the free-space diffraction limit. The Mie scattering wavelengths of the antenna depend on the structural geometry, which allows the antennas to be used for colored imprint images. However, there is still room for improving the spatial resolution, and new polarization-dependent color functionalities are highly desirable for realizing a wider color tuning range. Here, we show all-dielectric color printing by means of dual-color pixels with a subwavelength-scale resolution...
November 15, 2017: Nano Letters
https://www.readbyqxmd.com/read/29141058/disparity-in-cutaneous-pigmentary-response-to-led-vs-halogen-incandescent-visible-light-results-from-a-single-center-investigational-clinical-trial-determining-a-minimal-pigmentary-visible-light-dose
#4
Teo Soleymani, David E Cohen, Lorcan M Folan, Uchenna R Okereke, Nada Elbuluk, Nicholas A Soter
<p>Background: While most of the attention regarding skin pigmentation has focused on the effects of ultraviolet radiation, the cutaneous effects of visible light (400 to 700nm) are rarely reported. OBJECTIVE: The purpose of this study was to investigate the cutaneous pigmentary response to pure visible light irradiation, examine the difference in response to different sources of visible light irradiation, and determine a minimal pigmentary dose of visible light irradiation in melanocompetent subjects with Fitzpatrick skin type III - VI...
November 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29140820/renal-effects-of-cytokines-in-hypertension
#5
Yi Wen, Steven D Crowley
PURPOSE OF REVIEW: Inflammatory cytokines contribute to the pathogenesis of hypertension through effects on renal blood flow and sodium handling. This review will update recent advances that explore the renal actions of immune cells and cytokines in the pathogenesis of hypertension. RECENT FINDINGS: Populations of cells from both the innate and adaptive immune systems contribute to hypertension by modulating functions of the vasculature and epithelial cells in the kidney...
November 14, 2017: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/29140697/accurate-excited-state-geometries-a-caspt2-and-coupled-cluster-reference-database-for-small-molecules
#6
Simon Budzak, Giovanni Scalmani, Denis Jacquemin
We present an investigation of the excited-state structural parameters determined for a large set of small compounds with the dual goals of defining reference values for further works and assessing the quality of the geometries obtained with relatively cheap computational approaches. In the first stage, we compare the excited-state geometries obtained with ADC(2), CC2, CCSD, CCSDR(3), CC3 and CASPT2 and large atomic basis sets. It is found that CASPT2 and CC3 results are generally in very good agreement with one another (typical differences of ca...
November 15, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29140363/snapshot-second-harmonic-generation-polarimeter-based-on-spectral-analysis
#7
Matthieu Dubreuil, Sylvain Rivet, Yann Le Grand
A new high-speed second-harmonic generation (SHG) polarimetric method is reported. It is based on the spectral analysis of the SHG radiation emitted by a nonlinear medium excited with circularly polarized femtosecond laser pulses. The setup uses only passive components for polarization encoding and a fast spectrometer for spectral analysis. The method is validated on a z-cut quartz plate, then on a collagen-rich biological tissue with a view to single image polarization-resolved SHG microscopy.
November 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/29140360/ultracompact-high-extinction-ratio-polarization-beam-splitter-rotator-based-on-hybrid-plasmonic-dielectric-directional-coupling
#8
Bowen Bai, Lu Liu, Zhiping Zhou
A polarization beam splitter-rotator based on asymmetric directional coupling is proposed. An ultrashort cross-polarization coupling length of 7.7 μm is achieved by manipulating the optical field distribution via the plasmonic effect, which is the shortest one reported so far, to the best of our knowledge. At the wavelength of 1.55 μm, the extinction ratios are as high as 50.9 dB and 28.2 dB for fundamental transverse magnetic (TM0) and transverse electric (TE0) polarizations, respectively, and the corresponding insertion losses are 1...
November 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/29140352/extended-ellipticity-control-for-attosecond-pulses-by-high-harmonic-generation
#9
Nickolai Zhavoronkov, Mikhail Ivanov
Attosecond (1  as=10(-18)  s) pulses produced through high harmonic generation (HHG) are a basis for studies of electron dynamics during light-matter interaction on an electron's natural time scale. Extensively exploited HHG technology has, however, a few unsolved problems, where producing of circularly polarized or chiral attosecond pulses belongs to them. We have demonstrated experimentally a way to control the ellipticity of attosecond pulse trains produced via HHG in two-color, bi-circular laser fields...
November 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/29140340/response-of-an-erbium-doped-dual-polarization-fiber-laser-to-a-perpendicular-gradient-magnetic-field
#10
Tianfang Zhang, Jun Zhang, Linghao Cheng, Yizhi Liang, Long Jin, Hao Liang, Bai-Ou Guan
Direct interaction between fiber lasers and a magnetic field is useful but seldom explored because fiber is known as magnetic field insensitive. In this Letter, the response of an erbium-doped dual-polarization fiber laser to a perpendicular gradient magnetic field is investigated. Measured as beat note frequency change, significant response greater than 500 MHz has been observed that is within theoretical expectation, and translates to a birefringence change of about 4×10(-6) and a potentially very high response to a magnetic field of about 12...
November 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/29140322/fourier-processing-with-partially-coherent-fields
#11
Taco D Visser, Govind P Agrawal, Peter W Milonni
We describe how Fourier signal processing techniques can be generalized to partially coherent fields. Using standard coherence theory, we first show that focusing of a partially coherent beam by a lens modifies its coherence properties. We then consider a 4f imaging system composed of two lenses and discuss how spatial filtering in the Fourier plane allows one to tune the coherence properties of the beam. This, in turn, provides control over the beam's directionality, spectrum, and degree of polarization.
November 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/29140253/electrical-resistivity-and-wave-character-of-free-electrons-in-amorphous-and-nanoglass-sc-sub-75-sub-fe-sub-25-sub
#12
Mohammad Ghafari, Wayne D Hutchison, Stewart J Campbell, Herbert Gleiter, Horst Hahn, Tao Feng
The residual electrical resistivity of metallic amorphous alloys, ρ0, is typically in the range 50 μΩ cm < ρ0 < 310 μΩ cm corresponding to a mean free path of conduction electrons of order a few interatomic distances. In crystalline metals with low defect levels such as Cu however, the residual electrical resistivity is about ρ0 ≈ 1.54 x 10-2 μΩ cm, leading to extensive progression of free electrons through the crystalline material, of typically up to 4 x 106 nm. The relatively "high" values for the electrical resistivity of distorted Sc75Fe25 alloys are discussed here within the framework of the wave character of electrons...
November 15, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29140228/co-factor-independent-phosphoglycerate-mutase-of-leishmania-donovani-modulates-macrophage-signalling-and-promotes-t-cell-repertoires-bearing-epitopes-for-both-mhc-i-and-mhc-ii
#13
Manish K Singh, Fauzia Jamal, Amit K Dubey, Pushkar Shivam, Sarita Kumari, Pushpanjali, Ghufran Ahmed, Manas R Dikhit, S Narayan, V N R DAS, Krishna Pandey, K K Sinha, P DAS, Shubhankar K Singh
Immunoactivation depends upon the antigen potential to modulate T-cell repertoires. The present study has enumerated the effect of 61 kDa recombinant Leishmania donovani co-factor-independent phosphoglycerate mutase (rLd-iPGAM) on mononuclear cells of healthy and treated visceral leishmaniasis subjects as well as on THP-1 cell line. rLd-iPGAM stimulation induced higher expression of interleukin-1β (IL-1β) in the phagocytic cell, its receptor and CD69 on T-cell subsets. These cellular activations resulted in upregulation of host-protective cytokines IL-2, IL-12, IL-17, tumour necrosis factor-α and interferon-γ, and downregulation of IL-4, IL-10 and tumour growth factor-β...
November 15, 2017: Parasitology
https://www.readbyqxmd.com/read/29140092/determinants-and-expansion-of-specificity-in-a-trichothecene-udp-glucosyltransferase-from-oryza-sativa
#14
Karl M Wetterhorn, Kaitlyn Gabardi, Herbert Michlmayr, Alexandra Malachova, Mark Busman, Susan Patricia McCormick, Franz Berthiller, Gerhard Adam, Ivan Rayment
Family 1 UDP-glycosyltransferases in plants (UGTs) primarily form glucose conjugates of small molecules and, besides other functions, play a role in detoxification of xenobiotics. Indeed, overexpression of a barley UGT in wheat has been shown to control Fusarium head blight, where this is a plant disease of global significance that leads to reduced crop yields and contamination with trichothecene mycotoxins such as deoxynivalenol (DON), T-2 toxin and many other structural variants. The UGT Os79 from rice has emerged as a promising candidate for inactivation of mycotoxins on account of its ability to glycosylate DON, nivalenol and hydrolyzed T-2 toxin (HT-2)...
November 15, 2017: Biochemistry
https://www.readbyqxmd.com/read/29139569/lipase-catalyzed-enantioselective-transesterification-of-prochiral-1-1-3-dihydroxypropan-2-yloxy-methyl-5-6-7-8-tetrahydroquinazoline-2-4-1h-3h-dione-in-ionic-liquids
#15
Renata Kołodziejska, Renata Studzińska, Hanna Pawluk
The application of ionic liquids as solvents for transesterification of prochiral pirymidine acyclonucleoside using lipase (EC 3.1.1.3) Amano PS from Burkholderia cepacia (BCL) is reported. The effect of using medium reaction, acyl group donor, and temperature on the activity and enantioselectivity of BCL was studied. From the investigated ionic solvents, the hydrophobic ionic liquid [BMIM]PF6 ] was the preferred medium for enzymatic reactions. However, the best result was obtained in the mixture [BMIM][PF6 ]:TBME (1:1 v/v) at 50°C...
November 15, 2017: Chirality
https://www.readbyqxmd.com/read/29139551/members-of-the-deal-subfamily-of-the-duf1218-gene-family-are-required-for-bilateral-symmetry-but-not-for-dorsoventrality-in-arabidopsis-leaves
#16
David Wilson-Sánchez, Sebastián Martínez-López, Sergio Navarro-Cartagena, Sara Jover-Gil, José Luis Micol
Most plant leaves exhibit bilateral symmetry, which has been hypothesized as an inevitable consequence of the existence of the proximodistal and dorsoventral axes. No gene has been described that affects leaf bilateral symmetry but not dorsoventrality in Arabidopsis thaliana. We screened for viable insertional mutations that affect leaf morphology, and out of more than 700 mutants found only one, desigual1-1 (deal1-1), that exhibited bilateral symmetry breaking but no obvious defects in dorsoventrality. We found that deal1-1 is an allele of VASCULATURE COMPLEXITY AND CONNECTIVITY (VCC)...
November 15, 2017: New Phytologist
https://www.readbyqxmd.com/read/29139536/planar-polarity-of-the-extraembryonic-epithelia-in-the-preimplantation-porcine-conceptus
#17
Jacques-Edmond Flechon
The present review deals with the trophoblast structure during the free intrauterine life of the pig blastocyst. The term trophoblast is used here to describe the association of the first extraembryonic cell layers, the trophectoderm and the primitive endoderm that are polarized epithelia, a fact established by ultrastructural and immunocytochemical data. The aim of this synthesis is to gather the relative works dispersed in the litterature and to explain the implication of the planar polarity of these cell layers on their developmental fate and roles...
2017: International Journal of Developmental Biology
https://www.readbyqxmd.com/read/29139525/electron-spin-fluctuation-in-intense-laser-fields
#18
Youssef Korani, Hassan Sabzyan
The effects of the orientation, wavelength and carrier-envelope phase of laser pulses on the spin fluctuation in HeH(2+) and LiH(3+) molecular ions in their bound electronic states, during their interactions with linearly polarized intense laser pulses, were investigated by solving numerically the time-dependent Dirac equation with the Foldy-Wouthuysen transformation. The results of this study showed that an increase in the wavelength of the laser pulse at a fixed intensity reduces the lifetime of the coherent spin states and increases the sensitivity of the spin vector to the applied laser field in both HeH(2+) and LiH(3+) species...
November 15, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29139497/weak-ferromagnetic-ordering-in-brownmillerite-ca2fe2o5-and-its-effect-on-electric-field-gradients
#19
Isao Kagomiya, Yuki Hirota, Ken-Ichi Kakimoto, Kotaro Fujii, Masahiro Shiraiwa, Masatomo Yashima, Akio Fuwa, Shin Nakamura
Brownmillerite Ca2Fe2O5 (CFO) exhibits a magnetic transition at TN ∼ 730 K. Many studies have reported the magnetic properties of CFO. However, the magnetic structure of CFO is still debated, i.e., whether the magnetic ordering is purely antiferromagnetic or weakly ferromagnetic, which originated from canted magnetic moments. In addition, the reason for the CFO showing large magnetoresistance is still unclear. This study attempts to address the unresolved issues stated above by multiple investigations on the crystal structure, magnetization, and Mössbauer parameters...
November 15, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29139350/nemorella-caseinilytica-gen-nov-sp-nov-isolated-from-forest-soil
#20
Dhiraj Kumar Chaudhary, Ram Hari Dahal, Jaisoo Kim
Two novel strains, J116-2(T) and J116-1, were isolated from forest soil and were taxonomically characterized by a polyphasic approach. Both strains were yellow-coloured, Gram-stain-negative, strictly aerobic, non-motile and rod-shaped bacteria. The strains were non-sporulating, catalase-positive and oxidase-negative. Strains J116-2(T) and J116-1 were able to grow at 20-32 °C, pH 6.0-8.5, and 0-0.5 % (w/v) NaCl concentration. Based on 16S rRNA gene sequence analyses, strains J116-2(T) and J116-1 formed a distinct lineage within the family Chitinophagaceae of the phylum Bacteroidetes and were closely related to genera Taibaiella (89...
November 15, 2017: International Journal of Systematic and Evolutionary Microbiology
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