Gabriella Maria Andriani, Lais Fernanda de Almeida Spoladori, Marciéli Fabris, Priscila Goes Camargo, Patrícia Morais Lopes Pereira, Jussevania Pereira Santos, Guilherme Bartolomeu-Gonçalves, Lais Alonso, Cesar Armando Contreras Lancheros, Antonio Alonso, Celso Vataru Nakamura, Fernando Macedo, Phileno Pinge-Filho, Lucy Megumi Yamauchi, Marcelle de Lima Ferreira Bispo, Eliandro Reis Tavares, Sueli Fumie Yamada-Ogatta
INTRODUCTION: Cryptococcus neoformans is one of the leading causes of invasive fungal infections worldwide. Cryptococcal meningoencephalitis is the main challenge of antifungal therapy due to high morbidity and mortality rates, especially in low- and middle-income countries. This can be partly attributed to the lack of specific diagnosis difficulty accessing treatment, antifungal resistance and antifungal toxicity. METHODS: In the present study, the effect of the synthetic thiourea derivative N -(butylcarbamothioyl) benzamide (BTU-01), alone and combined with amphotericin B (AmB), was evaluated in planktonic and sessile (biofilm) cells of C...
2023: Frontiers in Microbiology