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https://www.readbyqxmd.com/read/29143757/simultaneous-determination-of-seven-anthraquinone-aglycones-of-crude-and-processed-semen-cassiae-extracts-in-rat-plasma-by-uplc-ms-ms-and-its-application-to-a-comparative-pharmacokinetic-study
#1
Rixin Guo, Hongwei Wu, Xiankuo Yu, Mengying Xu, Xiao Zhang, Liying Tang, Zhuju Wang
Semen cassiae is the ripe seed of Cassia obtusifolia L. or Cassia tora L. of the family Leguminosae. In traditional Chinese medicine, the two forms of Semen cassiae are raw Semen cassiae (R-SC) and parched Semen cassiae (P-SC). To clarify the processing mechanism of Semen cassiae, the pharmacokinetics of R-SC and P-SC extracts were examined. A simple, rapid, sensitive ultra-high-performance liquid chromatography-tandem mass spectroscopy (UPLC-MS/MS) method was developed and validated for the simultaneous determination of seven anthraquinone aglycones of Semen cassiae (aurantio-obtusin, obtusifolin, questin, 2-hydroxyemodin-1-methyl-ether, rhein, emodin, 1,2,7-trimethoxyl-6,8-dihydroxy-3-methylanthraquinone) to compare the pharmacokinetics of raw and parched Semen cassiae in rat plasma...
October 28, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29141604/genome-wide-identification-of-mirnas-and-lncrnas-in-cajanus-cajan
#2
Chandran Nithin, Amal Thomas, Jolly Basak, Ranjit Prasad Bahadur
BACKGROUND: Non-coding RNAs (ncRNAs) are important players in the post transcriptional regulation of gene expression (PTGR). On one hand, microRNAs (miRNAs) are an abundant class of small ncRNAs (~22nt long) that negatively regulate gene expression at the levels of messenger RNAs stability and translation inhibition, on the other hand, long ncRNAs (lncRNAs) are a large and diverse class of transcribed non-protein coding RNA molecules (> 200nt) that play both up-regulatory as well as down-regulatory roles at the transcriptional level...
November 15, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29117745/antihyperglycemic-antihyperlipidemic-and-antioxidative-evaluation-of-compounds-from-senna-sophera-l-roxb-in-streptozotocin-induced-diabetic-rats
#3
Amol R Kharat, Kiran Kharat, Mahadev Jadhav, S J Makhija
Senna sophera (L.) Roxb (Common name: Kasunda, Baner) (Leguminosae) is used as traditional medicine in Africa and Asia. The compounds were isolated from methanolic extract of leaves of Senna sophera (MFCS). Compound A was identified as Hexahydroxy diphenic acid and Compound B as Kaempferol. MFCS administration to diabetic rats exhibited significant reduction in the blood sugar level and showed gain in body weight. After the treatment of 100 mg/kg of MFCS, the blood sugar level was reduced to 52.33 ± 2.83 mg/dl in comparison to the blood sugar level of vehicle control 76...
November 8, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29098509/identification-of-seeds-based-on-molecular-markers-and-secondary-metabolites-in-senna-obtusifolia-and-senna-occidentalis
#4
Renjun Mao, Pengguo Xia, Zhigui He, Yan Liu, Fenghua Liu, Hongguang Zhao, Ruilian Han, Zongsuo Liang
BACKGROUND: Senna obtusifolia and Senna occidentalis (Leguminosae), whose seeds have similar appearance and chemical constituents, are easily confused in using their seeds. To elucidate the similarities and differences between S. obtusifolia seeds and S. occidentalis seeds, three molecular markers and high performance liquid chromatography (HPLC) were employed to evaluate the seeds characteristics of these two medicinal herbs. RESULTS: The results showed that selected 3 ISSR and 7 SCoT primers could distinguish S...
November 2, 2017: Botanical Studies (Taipei, Taiwan)
https://www.readbyqxmd.com/read/29022875/spatio-temporal-control-of-mutualism-in-legumes-helps-spread-symbiotic-nitrogen-fixation
#5
Benoit Daubech, Philippe Remigi, Ginaini Doin de Moura, Marta Marchetti, Cécile Pouzet, Marie-Christine Auriac, Chaitanya S Gokhale, Catherine Masson-Boivin, Delphine Capela
Mutualism is of fundamental importance in ecosystems. Which factors help to keep the relationship mutually beneficial and evolutionarily successful is a central question. We addressed this issue for one of the most significant mutualistic interactions on Earth, which associates plants of the leguminosae family and hundreds of nitrogen (N2)-fixing bacterial species. Here we analyze the spatio-temporal dynamics of fixers and non-fixers along the symbiotic process in the Cupriavidus taiwanensis-Mimosa pudica system...
October 12, 2017: ELife
https://www.readbyqxmd.com/read/28990503/effects-of-isolated-isoflavones-intake-on-health
#6
Antonella Smeriglio, Antonella Calderaro, Marcella Denaro, Giuseppina Laganà, Ersilia Bellocco
Isoflavones are naturally occurring flavonoids characterized by a structure able to exert non-steroidal estrogen-like activity on human cells. The atypical linkage between the rings B and C remarkable influences these potentialities and confers them specific applications, along with the biochemical modification such as acetylation and malonylation. Plants belonging to Leguminosae family are the most abundant and rich sources for human organism, where, after their ingestion and metabolization, they show positive health effects on several diseases, especially in the prevention of coronary heart and neurological diseases, hormone-related cancers, osteoporosis, and postmenopausal symptoms...
October 6, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28990045/anti%C3%A2-tumor-effects-of-bakuchiol-on-human-gastric-carcinoma-cell-lines-are-mediated-through-pi3k-akt-and-mapk-signaling-pathways
#7
Long Lv, Bo Liu
Bakuchiol is extracted from Psoralea corylifolia, a member of the Leguminosae family, has been used in Indian Ayurvedic and Chinese traditional medicine, and it possesses an anticancer effect. The primary aim of the present study was to identify the molecular mechanisms underlying the anticancer effect of bakuchiol monoterpenes. Bakuchiol treatment significantly inhibited NUGC3 human gastric cancer cell viability in a concentration dependent manner. In addition, bakuchiol significantly increased the apoptotic cell population in the sub‑G1 phase, and Annexin‑V‑fluorescein isothiocyanate/propidium iodide double staining confirmed the increase in apoptosis...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28982307/psoralea-corylifolia-extract-induces-vasodilation-in-rat-arteries-through-both-endothelium-dependent-and-independent-mechanisms-involving-inhibition-of-trpc3-channel-activity-and-elaboration-of-prostaglandin
#8
Addis Kassahun Gebremeskel, Tharaka Darshana Wijerathne, Ji Hyun Kim, Min Ji Kim, Chang-Seob Seo, Hyeun-Kyoo Shin, Kyu Pil Lee
CONTEXT: Fructus Psoralea, Psoralea corylifolia L. (Leguminosae), has been widely used in traditional medicines for the treatment of dermatitis, leukoderma, asthma and osteoporosis. OBJECTIVES: In this study, we sought to study mechanisms underlying the vasoactive properties of Psoralea corylifolia extract (PCE) and its active ingredients. MATERIALS AND METHODS: To study mechanisms underlying the vasoactive properties of PCE prepared by extracting dried seeds of Psoralea corylifolia with 70% ethanol, isometric tension recordings of rat aortic rings and the ionic currents through TRPC3 (transient receptor potential canonical 3) channels were measured with the cumulative concentration (10-600 μg/mL) of PCE or its constituents...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28973728/morphological-cytogenetic-and-molecular-characterization-of-arachis-kuhlmannii-krapov-w-c-greg-leguminosae
#9
A P Fávero, A P S Peñaloza, C R Lopes, J F M Valls
Arachis kuhlmannii occurs in Mato Grosso and Mato Grosso do Sul States, Brazil. Its area of occurrence partially overlaps with that of other species in the Arachis section. Because of their morphological similarities, these species are often mistaken one for another. This study aimed the correct classification of available accessions as Arachis kuhlmannii, or other species, and the characterization of similarities among accessions and Arachis hypogaea by morphological, cytogenetic, and molecular marker analyses...
September 21, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28965009/licochalcone-a-induces-morphological-and-biochemical-alterations-in-schistosoma-mansoni-adult-worms
#10
Ritieres Lovo Souza, Ubirajara Oliveira Gonçalves, Fernanda Rafacho Badoco, Lucas de Souza Galvão, Raquel Alves Dos Santos, Paulo Henrique Dias de Carvalho, Lara Soares Aleixo de Carvalho, Ademar Alves da Silva Filho, Rodrigo Cássio Sola Veneziani, Vanderlei Rodrigues, Sérgio Ricardo Ambrósio, Lizandra Guidi Magalhães
This paper is the first report on the in vitro effects of licochalcone A, a chalcone isolated from Glycyrrhiza inflate Batalin (Leguminosae), on Schistosoma mansoni adult worms. In vitro, licochalcone A afforded lethal concentrations for 50% of parasites (LC50) of 9.12±1.1 and 9.52±0.9μM against female and male adult worms, respectively, at 24h. Additionally, the compound reduced the total number of S. mansoni eggs and affected the development of eggs produced by S. mansoni adult worms. Together, the results achieved after 24h showed that licochalcone A was 55...
September 28, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28964376/phytochemical-profiling-of-underexploited-fabaceae-species-insights-on-the-ontogenic-and-phylogenetic-effects-over-isoflavone-levels
#11
João C M Barreira, Tatiana Visnevschi-Necrasov, Graça Pereira, Eugénia Nunes, M Beatriz P P Oliveira
There is an increasing trend towards finding alternative sources of valued phytochemicals due to their diverse potentialities in food industry and pharmaceutical applications. Phenolic compounds, in particular, have been the focus of several profiling reports, but isoflavones characterization has been studied in fewer cases and in a very limited group of plant species. Despite their acknowledged bioactivity, there's actually a strict number of plants validated for their isoflavones contents. In a previous report, we have identified nine Leguminosae species (from genera Biserrula, Lotus, Ornithopus and Scorpiurus) as potential alternative sources of these phenolic compounds...
October 2017: Food Research International
https://www.readbyqxmd.com/read/28959634/safety-assessment-of-freeze-dried-powdered-cassiae-semen-evaluation-of-chronic-toxicity-26-week-in-sprague-dawley-rats
#12
Yanyu Pei, Ruoyao Wei, Jingjiang Sun, Hong Gao
There is a lack of safety assessment data regarding the long-term consumption of Cassiae Semen (Leguminosae, the seeds of Cassia obtusifolia L. and Cassia tora L.). Thus, we evaluated the toxicity of freeze-dried powdered Cassiae Semen in male and female Sprague-Dawley rats. Rats were intragastrically administered freeze-dried powdered Cassiae Semen at a dose of 0.5, 2.2, or 10.0 g/kg body weight/day for 26 weeks; several variables were assessed after 13 and 26 weeks as well as after a 4-week recovery period...
2017: Toxicology Reports
https://www.readbyqxmd.com/read/28944625/allergy-to-peanut-soybean-and-other-legumes-recent-advances-in-allergen-characterization-stability-to-processing-and-ige-cross-reactivity
#13
REVIEW
Beatriz Cabanillas, Uta Jappe, Natalija Novak
Peanut and soybean are members of the Leguminosae family. They are two of the eight foods that account for the most significant food allergies in the US and Europe. Allergic reactions to other legume species can be of importance in other regions of the world. The major allergens from peanut and soybean have been extensively analyzed and members of new protein families identified as potential marker allergens for symptom severity. Important recent advances concerning their molecular properties or clinical relevance have been made...
September 25, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28925932/chloroplast-genome-sequence-of-clusterbean-cyamopsis-tetragonoloba-l-genome-structure-and-comparative-analysis
#14
Tanvi Kaila, Pavan K Chaduvla, Hukam C Rawal, Swati Saxena, Anshika Tyagi, S V Amitha Mithra, Amolkumar U Solanke, Pritam Kalia, T R Sharma, N K Singh, Kishor Gaikwad
Clusterbean (Cyamopsis tetragonoloba L.), also known as guar, belongs to the family Leguminosae, and is an annual herbaceous legume. Guar is the main source of galactomannan for gas mining industries. In the present study, the draft chloroplast genome of clusterbean was generated and compared to some of the previously reported legume chloroplast genomes. The chloroplast genome of clusterbean is 152,530 bp in length, with a quadripartite structure consisting of large single copy (LSC) and small single copy (SSC) of 83,025 bp and 17,879 bp in size, respectively, and a pair of inverted repeats (IRs) of 25,790 bp in size...
September 19, 2017: Genes
https://www.readbyqxmd.com/read/28919947/genomic-characterisation-of-arachis-porphyrocalyx-valls-c-e-simpson-2005-leguminosae-multiple-origin-of-arachis-species-with-x-9
#15
Silvestri María Celeste, Alejandra Marcela Ortiz, Germán Ariel Robledo, José Francisco Montenegro Valls, Graciela Inés Lavia
The genus Arachis Linnaeus, 1753 comprises four species with x = 9, three belong to the section Arachis: Arachis praecox (Krapov. W.C. Greg. & Valls, 1994), Arachis palustris (Krapov. W.C. Greg. & Valls, 1994) and Arachis decora (Krapov. W.C. Greg. & Valls, 1994) and only one belongs to the section Erectoides: Arachis porphyrocalyx (Valls & C.E. Simpson, 2005). Recently, the x = 9 species of section Arachis have been assigned to G genome, the latest described so far. The genomic relationship of Arachis porphyrocalyx with these species is controversial...
2017: Comparative Cytogenetics
https://www.readbyqxmd.com/read/28911661/corrigendum-to-biopharmaceutical-potentials-of-prosopis-spp-mimosaceae-leguminosa-j-food-drug-anal-25-2017-187-196
#16
Santhaseelan Henciya, Prabha Seturaman, Arthur Rathinam James, Yi-Hong Tsai, Rahul Nikam, Yang-Chang Wu, Hans-Uwe Dahms, Fang Rong Chang
No abstract text is available yet for this article.
July 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28911536/biopharmaceutical-potentials-of-prosopis-spp-mimosaceae-leguminosa
#17
REVIEW
Santhaseelan Henciya, Prabha Seturaman, Arthur Rathinam James, Yi-Hong Tsai, Rahul Nikam, Yang-Chang Wu, Hans-Uwe Dahms, Fang Rong Chang
Prosopis is a commercially important plant genus, which has been used since ancient times, particularly for medicinal purposes. Traditionally, Paste, gum, and smoke from leaves and pods are applied for anticancer, antidiabetic, anti-inflammatory, and antimicrobial purposes. Components of Prosopis such as flavonoids, tannins, alkaloids, quinones, or phenolic compounds demonstrate potentials in various biofunctions, such as analgesic, anthelmintic, antibiotic, antiemetic, microbial antioxidant, antimalarial, antiprotozoal, antipustule, and antiulcer activities; enhancement of H(+), K(+), ATPases; oral disinfection; and probiotic and nutritional effects; as well as in other biopharmaceutical applications, such as binding abilities for tablet production...
January 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28910286/potential-dna-barcodes-for-melilotus-species-based-on-five-single-loci-and-their-combinations
#18
Fan Wu, Jinxing Ma, Yuqin Meng, Daiyu Zhang, Blaise Pascal Muvunyi, Kai Luo, Hongyan Di, Wenli Guo, Yanrong Wang, Baochang Feng, Jiyu Zhang
Melilotus, an annual or biennial herb, belongs to the tribe Trifolieae (Leguminosae) and consists of 19 species. As an important green manure crop, diverse Melilotus species have different values as feed and medicine. To identify different Melilotus species, we examined the efficiency of five candidate regions as barcodes, including the internal transcribed spacer (ITS) and two chloroplast loci, rbcL and matK, and two non-coding loci, trnH-psbA and trnL-F. In total, 198 individuals from 98 accessions representing 18 Melilotus species were sequenced for these five potential barcodes...
2017: PloS One
https://www.readbyqxmd.com/read/28894631/ethnopharmacological-survey-on-traditional-medicinal-plants-at-kalaroa-upazila-satkhira-district-khulna-division-bangladesh
#19
Oby Dulla, Farhana Israt Jahan
AIM: The traditional source of medicinal plants is an important way for daily curative uses in the rural area throughout Bangladesh. An ethnomedicinal survey was conducted in a randomized manner among traditional medicinal practitioners to find out about the medicinal plants of Kalaroa, Bangladesh. MATERIALS AND METHODS: The information was collected through conducting interviews, discussion, and field observations with herbal healers and knowledgeable elders of the study areas from November 01, 2015, to December 31, 2015, who pointed out various medicinal plants and described their uses, using semi-structured questionnaires...
July 2017: Journal of Intercultural Ethnopharmacology
https://www.readbyqxmd.com/read/28888089/antidiabetic-potential-of-polyphenolic-rich-fraction-of-tamarindus-indica-seed-coat-in-alloxan-induced-diabetic-rats
#20
Santosh Singh Bhadoriya, Aditya Ganeshpurkar, Ravi Pratap Singh Bhadoriya, Sanjeev Kumar Sahu, Jay Ram Patel
BACKGROUND: Tamarindus is a monotypic genus and belongs to the subfamily Caesalpinioideae of the family Leguminosae (Fabaceae), Tamarindus indica L., commonly known as Tamarind tree is one of the most important multipurpose tropical fruit tree species in the India, Sudan, Nigeria, Bangladesh and entire subcontinent. METHODS: Hydroethanolic seed coat extract of Tamarindus indica (HETI) was assessed for presence of phytoconstituents and selection of optimum dose through acute and sub acute toxicity study...
September 9, 2017: Journal of Basic and Clinical Physiology and Pharmacology
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