Thibault Kervarrec, Daniel Pissaloux, Franck Tirode, Arnaud de la Fouchardière, Pierre Sohier, Eric Frouin, Aymeric Hamard, Roland Houben, David Schrama, Anne Barlier, Bernard Cribier, Maxime Battistella, Nicolas Macagno
Poroma is a benign sweat gland tumour showing morphological features recapitulating the superficial portion of the eccrine sweat coil. A subset of poromas may transform into porocarcinoma, its malignant counterpart. Poroma and porocarcinoma are characterised by recurrent gene fusions involving YAP1, a transcriptional co-activator, which is controlled by the Hippo signalling pathway. The fusion genes frequently involve MAML2 and NUTM1, which are also rearranged in other cutaneous and extracutaneous neoplasms...
August 23, 2023: Histopathology