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https://www.readbyqxmd.com/read/28095473/the-asymmetric-cell-division-regulators-par3-scribble-and-pins-gpsm2-are-not-essential-for-erythroid-development-or-enucleation
#1
Christina B Wölwer, Nathan Gödde, Luke B Pase, Imogen A Elsum, Krystle Y B Lim, Faruk Sacirbegovic, Carl R Walkley, Sarah Ellis, Shigeo Ohno, Fumio Matsuzaki, Sarah M Russell, Patrick O Humbert
Erythroid enucleation is the process by which the future red blood cell disposes of its nucleus prior to entering the blood stream. This key event during red blood cell development has been likened to an asymmetric cell division (ACD), by which the enucleating erythroblast divides into two very different daughter cells of alternate molecular composition, a nucleated cell that will be removed by associated macrophages, and the reticulocyte that will mature to the definitive erythrocyte. Here we investigated gene expression of members of the Par, Scribble and Pins/Gpsm2 asymmetric cell division complexes in erythroid cells, and functionally tested their role in erythroid enucleation in vivo and ex vivo...
2017: PloS One
https://www.readbyqxmd.com/read/28089435/jejunal-gluconeogenesis-associated-with-insulin-resistance-level-and-its-evolution-after-roux-en-y-gastric-bypass
#2
Carolina Gutierrez-Repiso, Sara Garcia-Serrano, Francisco J Moreno-Ruiz, Guillermo Alcain-Martinez, Francisca Rodriguez-Pacheco, Eduardo Garcia-Fuentes
BACKGROUND: Intestinal gluconeogenesis (GNG) may play an important role in glucose homeostasis, but there is little information about the condition in humans. OBJECTIVES: To study the relationship between intestinal GNG and insulin resistance, its association with the evolution of morbidly obese patients after bariatric surgery, and the effect of insulin and or leptin. SETTING: Regional university hospital, Malaga (Spain). METHODS: Jejunal mRNA expression of genes involved in GNG was analyzed in 3 groups of morbidly obese patients who underwent Roux-en-Y gastric bypass: with low insulin resistance (MO-low-IR), with high insulin resistance (MO-high-IR), and with type 2 diabetes treated with metformin (MO-metf-T2D)...
December 2, 2016: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28053520/psychometric-properties-of-the-physical-activity-scale-for-the-elderly-in-chinese-patients-with-copd
#3
Yan-Xia Tao, Lan Wang, Xiao-Yan Dong, Hong Zheng, Ya-Shu Zheng, Xing-Yue Tang, Yue Zhao, Qing Zhang
BACKGROUND: For patients with COPD, physical activity (PA) is recommended as the core component of pulmonary rehabilitation, but there is lack of a validated questionnaire for assessing the PA effectively. AIM: To evaluate the reliability and validity of the Chinese version of Physical Activity Scale for the Elderly (PASE-C) in patients with COPD. METHODS: A cross-sectional study was conducted with 167 outpatients aged 60 years or older with COPD...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28013202/performance-of-screening-tools-for-psoriatic-arthritis-a-cross-sectional-study-in-primary-care
#4
Maren C Karreman, Angelique E A M Weel, Myrthe van der Ven, Marijn Vis, Ilja Tchetverikov, Tamar E C Nijsten, Marlies Wakkee, Johanna M W Hazes, Jolanda J Luime
OBJECTIVE: To compare the screening performance of the Psoriasis Epidemiology Screening Tool (PEST), Psoriatic Arthritis Screening and Evaluation (PASE) and Early Arthritis for Psoriatic Patients (EARP) questionnaires for detecting PsA among psoriasis patients in a primary care setting. METHODS: In a cross-sectional study, 473 primary care psoriasis patients at risk for PsA completed the PEST, PASE and EARP questionnaires and were clinically evaluated by a trained research nurse...
December 24, 2016: Rheumatology
https://www.readbyqxmd.com/read/27981025/long-term-effects-of-a-weight-loss-intervention-with-or-without-exercise-component-in-postmenopausal-women-a-randomized-trial
#5
Martijn de Roon, Willemijn A van Gemert, Petra H Peeters, Albertine J Schuit, Evelyn M Monninkhof
The aim of this study was to determine the long-term effects of a weight loss intervention with or without an exercise component on body weight and physical activity. Women were randomized to diet (n = 97) or exercise (N = 98) for 16 weeks. During the intervention, both groups had achieved the set goal of 5-6 kg weight loss. All women were re-contacted twelve months after study cessation for follow-up where body weight and physical activity were measured (PASE questionnaire and ActiGraph accelerometer)...
March 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/27938474/human-muse-cells-non-tumorigenic-pluripotent-like-stem-cells-have-the-capacity-for-liver-regeneration-by-specific-homing-and-replenishment-of-new-hepatocytes-in-liver-fibrosis-mouse-model
#6
Masahiro Iseki, Yoshihiro Kushida, Shohei Wakao, Takahiro Akimoto, Masamichi Mizuma, Fuyuhiko Motoi, Ryuta Asada, Shinobu Shimizu, Michiaki Unno, Gregorio Chazenbalk, Mari Dezawa
Muse cells, a novel type of non-tumorigenic pluripotent-like stem cells reside in the bone marrow, skin and adipose tissue, are collectable as cells positive for pluripotent surface marker SSEA-3. They are able to differentiate into cells representative of all three germ layers. The capacity of intravenously injected human bone marrow-Muse cells to repair the liver fibrosis model of immunodeficient mice was evaluated in this study. They exhibited the ability for differentiation spontaneously into hepatoblast/hepatocyte-lineage cells and high migration toward the serum and liver tissue of carbon tetrachloride-treated mice in vitro...
2, 2016: Cell Transplantation
https://www.readbyqxmd.com/read/27924167/reduction-of-falls-and-factors-affecting-falls-a-year-after-total-knee-arthroplasty-in-elderly-patients-with-severe-knee-osteoarthritis
#7
T Tsonga, M Michalopoulou, S Kapetanakis, E Giovannopoulou, P Malliou, G Godolias, P Soucacos
BACKGROUND: Total Knee Arthroplasty (TKA) is a common surgical treatment for severe knee Osteoarthritis (OA), which generally improves pain, physical function, quality of life and possibly fall risk. Fall risk increases for older adults with severe knee OA; however it has not been studied extensively whether this parameter is improved after TKA. OBJECTIVE: To investigate: a) the history and frequency of falls, including mechanism or causes of falls, injuries sustained from falls reported, activity during falling and location of falls and, b) the factors affecting falls, a year after TKA in elderly patients with severe knee OA...
2016: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/27918596/degeneration-in-acl-injured-knees-with-and-without-reconstruction-in-relation-to-muscle-size-and-fat-content-data-from-the-osteoarthritis-initiative
#8
Pia M Jungmann, Thomas Baum, Michael C Nevitt, Lorenzo Nardo, Alexandra S Gersing, Nancy E Lane, Charles E McCulloch, Ernst J Rummeny, Thomas M Link
BACKGROUND: Anterior cruciate ligaments (ACL) injuries represent a major risk factor for early osteoarthritis (OA). PURPOSE: To evaluate the prevalence and 4-year progression of knee OA measured with 3T MR-imaging in individuals with ruptured, reconstructed or normal ACL and to assess the impact of thigh muscle characteristics. METHODS: A total of 54 knees (23/54 male, 31/54 female) were recruited from the Osteoarthritis Initiative (OAI). At baseline, 15/54 subjects had prevalent ACL ruptures and 15/54 subjects had prevalent ACL reconstruction (24/54 normal ACL)...
2016: PloS One
https://www.readbyqxmd.com/read/27918086/combined-therapy-with-swimming-exercise-and-a-diet-supplemented-with-diphenyl-diselenide-is-effective-against-age-related-changes-in-the-hepatic-metabolism-of-rats
#9
Suélen O Heck, Bruna C W Fulco, Caroline B Quines, Carla E S Oliveira, Marlon R Leite, José L Cechella, Cristina W Nogueira
Aging is characterized by a widespread loss of homeostasis in biological systems and is accompanied by pathophysiological changes including the liver injury. The aim of the present study was to investigate the effects of the combined therapy with swimming exercise (20 min session, 5 days/week during 4 weeks) and a diet supplemented with 1 ppm of (PhSe)2 on the hepatic metabolic alterations caused by aging in rats. In this study, male old Wistar rats had an increase in the epididymal fat relative weight, disturbances in the activities of hepatic enzymes associated to the glucose homeostasis, higher hepatic triglyceride content and higher activity of the plasma alanine aminotransferase (ALT), and aspartate aminotransferase (AST)...
December 5, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27902846/physical-activity-and-other-determinants-of-survival-in-the-oldest-adults
#10
Antonio Muscari, Giampaolo Bianchi, Paola Forti, Marco Giovagnoli, Donatella Magalotti, Paolo Pandolfi, Marco Zoli
OBJECTIVES: To determine the role of physical activity as a possible survival determinant in the oldest adults. DESIGN: Prospective, longitudinal, population-based cohort. SETTING: The Pianoro Study of community-dwelling older adults in three towns in northern Italy. PARTICIPANTS: Noninstitutionalized individuals aged 85 and older (n = 500; mean age 89.6 ± 3.1, 65% female). MEASUREMENTS: Participants provided information on marital status, educational level, previous work activity, cardiovascular risk factors, previous cardiovascular events, self-rated health, joint pain, and functional status...
November 30, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27864043/maternal-trans-fat-intake-during-pregnancy-or-lactation-impairs-memory-and-alters-bdnf-and-trkb-levels-in-the-hippocampus-of-adult-offspring-exposed-to-chronic-mild-stress
#11
Camila Simonetti Pase, Karine Roversi, Katiane Roversi, Luciana Taschetto Vey, Verônica Tironi Dias, Juliana Cristiana Veit, Luana Haselein Maurer, Thiago Duarte, Tatiana Emanuelli, Marta Duarte, Marilise Escobar Bürger
This study aimed to assess the influence of maternal dietary fat intake during pregnancy or lactation on memory of adult offspring after chronic mild stress (CMS) exposure. Female Wistar rats were supplemented daily with soybean oil/fish oil (SO/FO) or hydrogenated vegetable fat (HVF) by oral gavage (3.0g/kg body weight) during pregnancy or lactation. On post-natal day (PND) 60, half of the animals were exposed to CMS following behavioral assessments. While the adult offspring born under influence of SO/FO and HVF supplementations during pregnancy showed higher levels of n-3 and n-6 fatty acids (FA) series DHA and ARA metabolites, respectively, in the hippocampus, adult offspring born from supplemented dams during lactation showed higher levels of their precursors: ALA and LA...
February 1, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/27836567/management-of-psoriatic-arthritis-early-diagnosis-monitoring-of-disease-severity-and-cutting-edge-therapies
#12
REVIEW
Siba P Raychaudhuri, Reason Wilken, Andrea C Sukhov, Smriti K Raychaudhuri, Emanual Maverakis
Psoriatic arthritis (PsA) is a heterogeneous disease that can involve a variety of distinct anatomical sites including a patient's peripheral and axial joints, entheses, skin and nails. Appropriate management of PsA requires early diagnosis, monitoring of disease activity, and utilization of cutting edge therapies. To accomplish the former there are a variety of PsA-specific tools available to screen, diagnose, and assess patients. This review will outline the recently developed PsA screening tools, including the Toronto Psoriatic Arthritis Screening Questionnaire (TOPAS), the Psoriasis Epidemiology Screening Tool (PEST), the Psoriatic Arthritis Screening and Evaluation (PASE), and the Psoriasis and Arthritis Screening Questionnaire (PASQ)...
January 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/27829017/physical-activity-patterns-in-normal-weight-and-overweight-obese-pregnant-women
#13
Elisabetta Bacchi, Cecilia Bonin, Maria Elisabetta Zanolin, Francesca Zambotti, Dario Livornese, Silvia Donà, Flavia Tosi, Giulia Baldisser, Tatsiana Ihnatava, Daniela Di Sarra, Enzo Bonora, Paolo Moghetti
The aims of the present study were to assess the volume of physical activity (PA) throughout pregnancy in normal-weight vs overweight/obese women, and to investigate which factors may predict compliance to PA recommendations in these women throughout gestation. In 236 pregnant women, 177 normal-weight and 59 overweight/obese (median[IQR] BMI 21.2[19.9-22.8] vs 26.5[25.5-29.0] kg/m2, respectively), medical history, anthropometry and clinical data, including glucose tolerance, were recorded. In addition, pre-pregnancy PA was estimated by the Kaiser questionnaire, while total, walking and fitness/sport PA during pregnancy were assessed by the Physical Activity Scale for the Elderly (PASE) modified questionnaire, at 14-16, 24-28 and 30-32 weeks of gestation...
2016: PloS One
https://www.readbyqxmd.com/read/27804013/healthcare-needs-of-and-access-barriers-for-brazilian-transgender-and-gender-diverse-people
#14
Angelo Brandelli Costa, Heitor Tome da Rosa Filho, Paola Fagundes Pase, Anna Martha Vaitses Fontanari, Ramiro Figueiredo Catelan, Andressa Mueller, Dhiordan Cardoso, Bianca Soll, Karine Schwarz, Maiko Abel Schneider, Daniel Augusto Mori Gagliotti, Alexandre Saadeh, Maria Inês Rodrigues Lobato, Henrique Caetano Nardi, Silvia Helena Koller
Transgender and gender diverse people (TGD) have specific healthcare needs and struggles with access barriers that should be addressed by public health systems. Our study aimed to address this topic in the Brazilian context. A hospital and web-based cross-sectional survey built with input from the medical and transgender communities was developed to assess TGD healthcare needs of and access barriers in two Brazilian states. Although services that assist this population have existed in Brazil since the 1990s, TGD have difficulty accessing these services due to discrimination, lack of information and a policy design that does not meet the needs of TGD...
November 1, 2016: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/27696795/the-relationship-between-attitudes-beliefs-and-physical-activity-in-older-adults-with-knee-pain-secondary-analysis-of-a-randomised-controlled-trial
#15
Jonathan G Quicke, Nadine E Foster, Reuben O Ogollah, Peter R Croft, Melanie A Holden
Objective To investigate how attitudes and beliefs about exercise relate to physical activity behaviour in older adults with knee pain attributable to osteoarthritis (OA). Design Secondary data analyses of a randomised controlled trial of exercise interventions (ISRCTN 93634563). Participants were adults over 45 years old with knee pain attributable to OA (n=514). Crude and adjusted cross-sectional and longitudinal associations between baseline i) Self-Efficacy for Exercise (SEE), ii) Positive Outcome Expectations for Exercise (POEE), iii) Negative Outcome Expectations for Exercise (NOEE) and physical activity level at baseline, 3 and 6 months follow-up (measured by the self-report Physical Activity Scale for the Elderly (PASE)) and important increase in physical activity level (from baseline to 6 month follow-up) were investigated using multiple linear and logistic regression...
October 1, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27676223/current-physical-activity-is-independently-associated-with-cortical-bone-size-and-bone-strength-in-elderly-swedish-women
#16
Martin Nilsson, Daniel Sundh, Dan Mellström, Mattias Lorentzon
Physical activity is believed to have the greatest effect on the skeleton if exerted early in life, but whether or not possible benefits of physical activity on bone microstructure or geometry remain at old age has not been investigated in women. The aim of this study was to investigate if physical activity during skeletal growth and young adulthood or at old age was associated with cortical geometry and trabecular microarchitecture in weight-bearing and non-weight bearing bone, and areal bone mineral density (aBMD) in elderly women...
September 27, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/27659741/a-multidisciplinary-telehealth-program-in-patients-with-combined-chronic-obstructive-pulmonary-disease-and-chronic-heart-failure-study-protocol-for-a-randomized-controlled-trial
#17
Palmira Bernocchi, Simonetta Scalvini, Tiziana Galli, Mara Paneroni, Doriana Baratti, Ottavia Turla, Maria Teresa La Rovere, Maurizio Volterrani, Michele Vitacca
BACKGROUND: Chronic obstructive pulmonary disease (COPD) and chronic heart failure (CHF) frequently coexist, significantly reducing patients' quality of life and increasing morbidity and mortality. For either single disease, a multidisciplinary disease-management approach supported by telecommunication technologies offers the best outcome in terms of prolonged survival and reduced hospital readmissions. However, no data exist in patients with combined COPD/CHF. We planned a randomized controlled trial to investigate the feasibility and efficacy of an integrated, home-based, medical/nursing intervention plus a rehabilitation program versus conventional care in patients with coexisting COPD/CHF...
September 22, 2016: Trials
https://www.readbyqxmd.com/read/27588891/fear-of-falling-reduced-by-a-lay-led-home-based-program-in-frail-community-dwelling-older-adults-a-randomised-controlled-trial
#18
A Kapan, E Luger, S Haider, S Titze, K Schindler, C Lackinger, T E Dorner
BACKGROUND: In older adults, fear of falling (FOF) leads to a decline in daily physical activity quality of life and an increased risk of falling. The aim of this randomised controlled trial was to assess the effects of a 12-week home-based intervention program carried out by lay volunteers on FOF in frail older adults. METHODS: Thirty-nine participants were randomised to a physical training and nutrition (PTN) group and 41 participants to a social support (SOSU) group...
January 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/27580080/reduced-knee-adduction-moments-for-management-of-knee-osteoarthritis-a-three-month-phase-i-ii-randomized-controlled-trial
#19
Ryan T Lewinson, Isabelle A Vallerand, Kelsey H Collins, J Preston Wiley, Victor M Y Lun, Chirag Patel, Linda J Woodhouse, Raylene A Reimer, Jay T Worobets, Walter Herzog, Darren J Stefanyshyn
Wedged insoles are believed to be of clinical benefit to individuals with knee osteoarthritis by reducing the knee adduction moment (KAM) during gait. However, previous clinical trials have not specifically controlled for KAM reduction at baseline, thus it is unknown if reduced KAMs actually confer a clinical benefit. Forty-eight participants with medial knee osteoarthritis were randomly assigned to either a control group where no footwear intervention was given, or a wedged insole group where KAM reduction was confirmed at baseline...
October 2016: Gait & Posture
https://www.readbyqxmd.com/read/27567630/pase-and-earp-questionnaires-for-the-identification-of-enthesitis-synovitis-and-tenosynovitis-in-patients-with-psoriasis
#20
David Vidal, Dèlia Reina, José Luis Martin, Dacia Cerdà, Paula Estrada, Silvia García-Diaz, Vanessa Navarro, Laura Peramiquel, Daniel Roig, Vicenç Torrente, Hèctor Corominas
The aim of this study was to assess the diagnostic value of the Psoriatic Arthritis Screening Evaluation (PASE) and Early Psoriatic Arthritis Screening Questionnaire (EARP) questionnaires in the ultrasonographic detection of enthesitis, synovitis, and tenosynovitis. A cross-sectional study was done in a total of 96 consecutive patients. Double blind clinical examination and echographic assessment were performed. A receiver-operating characteristic (ROC) model analysis for the questionnaires was established using echographic findings as reference variable...
October 2016: Clinical Rheumatology
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