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Jonathan G Quicke, Nadine E Foster, Reuben O Ogollah, Peter R Croft, Melanie A Holden
Objective To investigate how attitudes and beliefs about exercise relate to physical activity behaviour in older adults with knee pain attributable to osteoarthritis (OA). Design Secondary data analyses of a randomised controlled trial of exercise interventions (ISRCTN 93634563). Participants were adults over 45 years old with knee pain attributable to OA (n=514). Crude and adjusted cross-sectional and longitudinal associations between baseline i) Self-Efficacy for Exercise (SEE), ii) Positive Outcome Expectations for Exercise (POEE), iii) Negative Outcome Expectations for Exercise (NOEE) and physical activity level at baseline, 3 and 6 months follow-up (measured by the self-report Physical Activity Scale for the Elderly (PASE)) and important increase in physical activity level (from baseline to 6 month follow-up) were investigated using multiple linear and logistic regression...
October 1, 2016: Arthritis Care & Research
Martin Nilsson, Daniel Sundh, Dan Mellström, Mattias Lorentzon
Physical activity is believed to have the greatest effect on the skeleton if exerted early in life, but whether or not possible benefits of physical activity on bone microstructure or geometry remain at old age has not been investigated in women. The aim of this study was to investigate if physical activity during skeletal growth and young adulthood or at old age was associated with cortical geometry and trabecular microarchitecture in weight-bearing and non-weight bearing bone, and areal bone mineral density (aBMD) in elderly women...
September 27, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Palmira Bernocchi, Simonetta Scalvini, Tiziana Galli, Mara Paneroni, Doriana Baratti, Ottavia Turla, Maria Teresa La Rovere, Maurizio Volterrani, Michele Vitacca
BACKGROUND: Chronic obstructive pulmonary disease (COPD) and chronic heart failure (CHF) frequently coexist, significantly reducing patients' quality of life and increasing morbidity and mortality. For either single disease, a multidisciplinary disease-management approach supported by telecommunication technologies offers the best outcome in terms of prolonged survival and reduced hospital readmissions. However, no data exist in patients with combined COPD/CHF. We planned a randomized controlled trial to investigate the feasibility and efficacy of an integrated, home-based, medical/nursing intervention plus a rehabilitation program versus conventional care in patients with coexisting COPD/CHF...
2016: Trials
A Kapan, E Luger, S Haider, S Titze, K Schindler, C Lackinger, T E Dorner
BACKGROUND: In older adults, fear of falling (FOF) leads to a decline in daily physical activity quality of life and an increased risk of falling. The aim of this randomised controlled trial was to assess the effects of a 12-week home-based intervention program carried out by lay volunteers on FOF in frail older adults. METHODS: Thirty-nine participants were randomised to a physical training and nutrition (PTN) group and 41 participants to a social support (SOSU) group...
August 28, 2016: Archives of Gerontology and Geriatrics
Ryan T Lewinson, Isabelle A Vallerand, Kelsey H Collins, J Preston Wiley, Victor M Y Lun, Chirag Patel, Linda J Woodhouse, Raylene A Reimer, Jay T Worobets, Walter Herzog, Darren J Stefanyshyn
Wedged insoles are believed to be of clinical benefit to individuals with knee osteoarthritis by reducing the knee adduction moment (KAM) during gait. However, previous clinical trials have not specifically controlled for KAM reduction at baseline, thus it is unknown if reduced KAMs actually confer a clinical benefit. Forty-eight participants with medial knee osteoarthritis were randomly assigned to either a control group where no footwear intervention was given, or a wedged insole group where KAM reduction was confirmed at baseline...
August 26, 2016: Gait & Posture
David Vidal, Dèlia Reina, José Luis Martin, Dacia Cerdà, Paula Estrada, Silvia García-Diaz, Vanessa Navarro, Laura Peramiquel, Daniel Roig, Vicenç Torrente, Hèctor Corominas
The aim of this study was to assess the diagnostic value of the Psoriatic Arthritis Screening Evaluation (PASE) and Early Psoriatic Arthritis Screening Questionnaire (EARP) questionnaires in the ultrasonographic detection of enthesitis, synovitis, and tenosynovitis. A cross-sectional study was done in a total of 96 consecutive patients. Double blind clinical examination and echographic assessment were performed. A receiver-operating characteristic (ROC) model analysis for the questionnaires was established using echographic findings as reference variable...
October 2016: Clinical Rheumatology
Jia Zhou, Jingjing Ling, Yong Wang, Jing Shang, Fengfeng Ping
Skin is the largest organ in our body and strategically placed to provide a metabolically active biological barrier against a range of noxious stressors. A lot of inflammatory cytokines, which are increased after ultraviolet (UV) irradiation produced by keratinocytes or other immunocytes, are closely related to pigmentary changes, including interleukin-18 (IL-18) and interferon-γ (IFN-γ). In this study, the effect of cross-talk between IL-18 and IFN-γ on melanogenesis was investigated. Treatment with IL-18 resulted in a dose-dependent increase of melanogenesis, while IFN-γ made an opposite effect...
October 2016: Journal of Photochemistry and Photobiology. B, Biology
Sunanda Panda, Anand Kar
The hitherto unknown role of saponin in the regulation of thyrotoxicosis has been revealed in chemically-induced thyrotoxic rats. l-T4 (l-thyroxine) administration at pre-standardized dose of 500-μg/kg body weight for 12days increased the levels of thyroid hormones, enhanced the activity of hepatic 5'-monodeiodinase I (5'DI) and glucose-6-phosphatase (G-6Pase) as well as lipid peroxidation (LPO) with a parallel decrease in the levels of antioxidative enzymes. However, administration of the isolated saponin for 15days ameliorated the T4-induced alterations in serum thyroid hormones, hepatic LPO, G-6-Pase and 5'DI activity, and improved the cellular antioxidant status, indicating its antithyroidal and antioxidative potential...
October 1, 2016: Bioorganic & Medicinal Chemistry Letters
Heng Zhao, Yingjie Sun, Jason M Peters, Carol A Gross, Ethan C Garner, John D Helmann
: The integrity of the bacterial cell envelope is essential to sustain life by countering the high turgor pressure of the cell and providing a barrier against chemical insults. In Bacillus subtilis, synthesis of both peptidoglycan and wall teichoic acids requires a common C55 lipid carrier, undecaprenyl-pyrophosphate (UPP), to ferry precursors across the cytoplasmic membrane. The synthesis and recycling of UPP requires a phosphatase to generate the monophosphate form Und-P, which is the substrate for peptidoglycan and wall teichoic acid synthases...
November 1, 2016: Journal of Bacteriology
S Mishra, H Kancharla, S Dogra, A Sharma
BACKGROUND: The objective of the present study was to evaluate the sensitivity and specificity of the Toronto Psoriatic Arthritis Screen II (ToPAS II), Psoriatic Arthritis Screening and Evaluation (PASE), Psoriasis Epidemiology Screening Tool (PEST) and Early Arthritis for Psoriatic Patients (EARP) questionnaires in diagnosing PsA in patients with Psoriasis (Pso) with CASPAR as gold standard. METHODS: This was a non-interventional, cross sectional study in which 302 Pso patients completed the ToPAS II, PASE, PEST and EARP prior to rheumatologic evaluation...
August 8, 2016: British Journal of Dermatology
Umberto Tarantino, Jacopo Baldi, Manuel Scimeca, Eleonora Piccirilli, Andrea Piccioli, Elena Bonanno, Elena Gasbarra
INTRODUCTION: Bone and muscle tissues are in a close relationship. They are linked from a biological and functional point of view and both are related to an increased fracture risk in the elderly. The aging process is involved in the loss of functionality of both bones and muscles. In particular, aging-induced decline in muscle size and quality accompanies catabolic alterations in bone tissue; furthermore, age-related changes in bone alter its response to muscle-derived stimulation. The increased fracture risk in individuals with sarcopenia and osteoporosis is due to the decline of muscle mass and strength, the decrease in bone mineral density (BMD) and limited mobility...
August 2, 2016: Injury
Matthew P Pase, Alexa Beiser, Jayandra J Himali, Connie Tsao, Claudia L Satizabal, Ramachandran S Vasan, Sudha Seshadri, Gary F Mitchell
BACKGROUND AND PURPOSE: Aortic stiffening increases the transfers of high pressure and flow pulsatility to small cerebral vessels potentially causing the accumulation of vascular brain injury. Our aim was to investigate the prospective association of aortic stiffness with the risks of incident mild cognitive impairment and dementia. METHODS: We studied 1101 dementia-free Framingham Offspring study participants (mean age, 69±6 years; 54% women). Aortic stiffness was measured as carotid-femoral pulse wave velocity using applanation tonometry and modeled as a linear variable and the top 2 quintiles (>11...
September 2016: Stroke; a Journal of Cerebral Circulation
Craig R Louer, Sean L Boone, Andre K Guthrie, John R Motley, Ryan P Calfee, Lindley B Wall
BACKGROUND: The physical risk factors leading to distal radial fractures are poorly understood. The goal of this study was to compare postural stability between older adults with and without a prior distal radial fragility fracture. METHODS: This case-control evaluation was performed at a single tertiary institution. The fracture cohort comprised 23 patients treated for a low-energy distal radial fracture within 6 to 24 months prior to this study. Twenty-three age and sex-matched control participants, without a prior fragility fracture, were selected from an outpatient clinic population...
July 20, 2016: Journal of Bone and Joint Surgery. American Volume
Yvonne Pasing, Sayda Colnoe, Terkel Hansen
In a comparative study we investigated the influence of nine sample preparation workflows and seven different lysis buffers for qualitative and quantitative analysis of the human adipose tissue proteome. Adipose tissue is not just a fat depot but also an endocrine organ, which cross-talks with other tissue types and organs throughout the body, like liver, muscle, pancreas and brain. Its secreted molecules have an influence on the nervous, immune and vascular system, thus adipose tissue plays an important role in the regulation of whole-body homeostasis...
July 14, 2016: Proteomics
Sandra Haider, Eva Luger, Ali Kapan, Sylvia Titze, Christian Lackinger, Karin E Schindler, Thomas E Dorner
PURPOSE: The aim of this study was to examine the associations between daily physical activity (DPA), handgrip strength, appendicular skeletal muscle mass (ASMM) and physical performance (balance, gait speed, chair stands) with quality of life in prefrail and frail community-dwelling older adults. METHODS: Prefrail and frail individuals were included, as determined by SHARE-FI. Quality of life (QoL) was measured with WHOQOL-BREF and WHOQOL-OLD, DPA with PASE, handgrip strength with a dynamometer, ASMM with bioelectrical impedance analysis and physical performance with the SPPB test...
June 30, 2016: Quality of Life Research
Karine Roversi, Camila Simonetti Pase, Katiane Roversi, Luciana Taschetto Vey, Verônica Tironi Dias, Vinícia Garzella Metz, Marilise Escobar Burger
The abuse of morphine has risen considerably in recent years, mainly due to the increase of its prescription in clinical medicine. Also, increased consumption of processed foods, rich in trans fatty acids (TFA), has caused concerns about human health. Thus, the aim of our study was to determine whether trans fat consumption in the perinatal period may affect preference for morphine in adolescent female and male rats. Dams were orally supplemented with water (C-control) or hydrogenated vegetable fat (HVF-rich in TFA) during gestation and lactation periods...
October 5, 2016: European Journal of Pharmacology
Robert M Kwee, Wolfgang Wirth, Nima Hafezi-Nejad, Bashir A Zikria, Ali Guermazi, Shadpour Demehri
OBJECTIVE: To assess the association between physical activity and cartilage damage progression in medial tibiofemoral compartment (MTFC) using 2-year follow-up magnetic resonance imaging (MRI) in subjects with denuded areas of subchondral bone (dABs) at the central weight-bearing medial femur (cMF) at baseline MRI examination. METHODS: One hundred subjects from the Osteoarthritis Initiative progression cohort with dABs at the cMF at 3T MRI at baseline (51% men; mean age 62...
June 17, 2016: Osteoarthritis and Cartilage
Ganesh Chandra Nandi, Maya Shankar Singh
Metal-free, p-toluenesulfonic acid (p-TSA)-mediated, straightforward propargylation of β-ketothioamides with aryl propargyl alcohol has been achieved at room temperature. In addition, the reaction also provided thiazole rings as byproducts. Furthermore, the propargylated thioamides undergo intramolecular 1,5-cyclization to afford fully substituted (hydro)thiophenes in the presence of base. Notably, the approach is pot, atom, and step economical (PASE).
July 15, 2016: Journal of Organic Chemistry
Cristina Gagliardi, Roberta Papa, Demetrio Postacchini, Cinzia Giuli
BACKGROUND: The incidence of people with dementia is expected to increase significantly in the coming years, but it seems that there is a relationship between an active lifestyle and cognitive decline. The present study aimed to compare the characteristics and engagement in the physical activity (PA) of three groups of Italian elderly with different cognitive statuses at baseline phase. METHODS: Data were examined using the results from the "My Mind Project" on 305 community-dwelling Italians...
2016: International Journal of Environmental Research and Public Health
Stefano Piaserico, Paolo Gisondi, Paolo Amerio, Giuseppe Amoruso, Anna Campanati, Andrea Conti, Clara De Simone, Giulio Gualdi, Claudio Guarneri, Anna Mazzotta, Maria L Musumeci, Damiano Abeni
Psoriatic arthritis (PsA) is a potentially severe inflammatory condition (entheso-arthro-osteopathy), and early diagnosis is important to guide treatment choices in patients with psoriasis. The objective of this study is to further validate the PsA Screening and Evaluation (PASE) questionnaire, and to assess its field performance. Data were collected in 10 Italian centres, and the PASE was administered at baseline, after 3 days and after 3 months. The Skindex-29 was also administered. To determine the best cut-off value to identify patients with PsA we produced receiver operating characteristic (ROC) curves using the rheumatologist's diagnosis as outcome...
August 23, 2016: Acta Dermato-venereologica
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