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https://www.readbyqxmd.com/read/29209877/effects-of-fish-and-grape-seed-oils-as-core-of-haloperidol-loaded-nanocapsules-on-oral-dyskinesia-in-rats
#1
Dalila Moter Benvegnú, Katiane Roversi, Raquel Cristine Silva Barcelos, Fabíola Trevizol, Camila Simonetti Pase, Hecson Jesser Segat, Verônica Tironi Dias, Ana Luiza Savian, Bruna Lopes Piccoli, Jaqueline Piccolo, Carlos Severo Dutra-Filho, Tatiana Emanuelli, Cristiane de Bona da Silva, Ruy Carlos Ruver Beck, Marilise Escobar Burger
Haloperidol is a widely used antipsychotic, despite the severe motor side effects associated with its chronic use. This study was carried out to compare oral dyskinesia induced by different formulations of haloperidol-loaded nanocapsules containing caprylic/capric triglycerides, fish oil or grape seed oil (GSO) as core, as well as free haloperidol. Haloperidol-loaded lipid-core nanocapsules formulations were prepared, physicochemical characterized and administered (0.5 mg kg-1-ip) to rats for 28 days. Oral dyskinesia was evaluated acutely and subchronically and after that cell viability and free radical generation in cortex and substantia nigra...
December 5, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/29197532/vascular-risk-factor-burden-and-new-onset-depression-in-the-community
#2
Shayna Adams, Sarah Conner, Jayandra J Himali, Alexa Beiser, Ramachandran S Vasan, Sudha Seshadri, Matthew P Pase
Depression is associated with an increased likelihood of cardiac events and stroke. We hypothesized that the vascular risk factor burden might itself predispose to both cardiovascular events and depression. Therefore, we examined whether aggregate scores of vascular risk factor burden were associated with the new-onset of depression in the community. We studied 2023 depression- and dementia-free Framingham Heart Study (Framingham, USA) Offspring participants who attended both examination cycles 7 (1998-2001) and 8 (2005-2008)...
November 29, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/29192470/the-stripp-questionnaire-screening-tool-for-rheumatologic-investigation-in-psoriatic-patients-as-a-new-tool-for-the-diagnosis-of-early-psoriatic-arthritis
#3
Martina Burlando, Emanuele Cozzani, Irene Schiavetti, Stefano Cicchelli, Marco Repetto, Gianluca Rossotto, Enrico Scaparro, Aurora Parodi
BACKGROUND: Psoriatic arthritis (PsA) is an inflammatory arthritis associated with psoriasis in up to one third of psoriatic patients. Clinically it's characterized from an insidious onset. To help clinicians screen for PsA, several screening tools have been developed. The psoriatic arthritis screening and evaluation questionnaire (PASE) is one of the most used in the Psocare units. The sensibility of PASE is of 83% with a cut off of 47 or greater. The aim of our study is to create an Italian self-administered questionnaire, lighter than the PASE, able to identify patients who need a rheumatologic consultation...
November 30, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29178359/elevated-luteinising-hormone-despite-normal-testosterone-levels-in-older-men-natural-history-risk-factors-and-clinical-features
#4
Robert J A H Eendebak, Tomas Ahern, Agnieszka Swiecicka, Stephen R Pye, Terence W O'Neill, Bartfai Gyorgy, Felipe F Casanueva, Mario Maggi, Gianni Forti, Aleksander Giwercman, Thang S Han, Jolanta Słowikowska-Hilczer, Michael E J Lean, Margus Punab, Neil Pendleton, Brian G Keevil, Dirk Vanderschueren, Martin K Rutter, Gindo Tampubolon, Royston Goodacre, Ilpo T Huhtaniemi, Frederick C W Wu
OBJECTIVE: Elevated LH with normal testosterone (T) suggests compensated dysregulation of the gonadal axis. We describe the natural history, risk factors and clinical parameters associated with the development of high LH (HLH, LH>9.4 U/L) in ageing men with normal T (T≥10.5 nmol/L). DESIGN, PATIENTS AND MEASUREMENTS: We conducted a 4.3 year prospective observational study of 3,369 community-dwelling European men aged 40-79 years. Participants were classified as: incident (i) HLH (n=101, 5...
November 27, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29164375/patient-reported-physical-activity-and-the-association-with-health-related-quality-of-life-in-head-and-neck-cancer-survivors
#5
Annette J van Nieuwenhuizen, Laurien M Buffart, Cornelia F van Uden-Kraan, Lilly-Ann van der Velden, Martin Lacko, Johannes Brug, C René Leemans, Irma M Verdonck-de Leeuw
PURPOSE: This study aimed to assess patient-reported levels of physical activity (PA) and its associations with health-related quality of life (HRQoL) adjusted for important demographic, lifestyle-related, and clinical factors, among head and neck (HNC) survivors. METHODS: This cross-sectional study included 116 HNC survivors. PA was assessed with the Physical Activity Scale for the Elderly (PASE) and HRQoL with the EORTC-QLQ-C30 and EORTC-HN35. Associations were studied using univariable and multivariable regression analyses...
November 21, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29134006/cecidonius-pampeanus-gen-et-sp-n-an-overlooked-and-rare-new-gall-inducing-micromoth-associated-with-schinus-in-southern-brazil-lepidoptera-cecidosidae
#6
Gilson R P Moreira, Rodrigo P Eltz, Ramoim B Pase, Gabriela T Silva, Sérgio A L Bordignon, Wolfram Mey, Gislene L Gonçalves
Galls induced by the larval stage of cecidosids (Lepidoptera: Cecidosidae) are complex, multi-trophic systems, still poorly studied. They may be associated with other insect feeding guilds, including inquilines, kleptoparasites, cecidophages, parasitoids, and predators. By causing death of the gall inducer early in life and altering the gall phenotype, inquilines may lead to misidentification of the true gall inducers. Here, we describe through light and scanning electron microscopy Cecidonius pampeanus, a new genus and species of cecidosid moth, from the Pampa biome, south Brazil...
2017: ZooKeys
https://www.readbyqxmd.com/read/29029009/the-effect-of-physical-activity-and-cardiorespiratory-fitness-on-all-cause-mortality-in-hong-kong-chinese-older-people
#7
Zhihui Lu, Jean Woo, Timothy Kwok
Background: It is unclear whether physical activity (PA) could predict all-cause mortality independently of cardiorespiratory fitness, and there are relatively few studies evaluating the combined effect of PA and cardiorespiratory fitness on mortality. Methods: We invited 1,242 Chinese older adults aged 69 to 94 years from the MrOs and MsOs cohort (Hong Kong) study for a 7-year follow-up. PA was measured by the Physical Activity Scale of the Elderly (PASE). Cardiorespiratory fitness, expressed as maximal oxygen uptake (VO2max), was assessed by performing symptom-limited maximal exercise testing on an electrically braked bicycle ergometer and 6-meter walk test...
September 19, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28985325/home-based-telerehabilitation-in-older-patients-with-chronic-obstructive-pulmonary-disease-and-heart-failure-a-randomised-controlled-trial
#8
Palmira Bernocchi, Michele Vitacca, Maria Teresa La Rovere, Maurizio Volterrani, Tiziana Galli, Doriana Baratti, Mara Paneroni, Giuseppe Campolongo, Barbara Sposato, Simonetta Scalvini
Background: chronic obstructive pulmonary disease (COPD) and chronic heart failure (CHF) frequently coexist in older people, reducing patients' quality of life (QoL) and increasing morbidity and mortality. Objective: we studied the feasibility and efficacy of an integrated telerehabilitation home-based programme (Telereab-HBP), 4 months long, in patients with combined COPD and CHF. The primary outcome was exercise tolerance evaluated at the 6-min walk test (6MWT)...
August 30, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28980277/straightforward-protocol-for-gel-free-proteomic-analysis-of-adipose-tissue
#9
Yvonne Pasing, Armin Schniers, Terkel Hansen
After conducting systematic and quantitative comparisons of different sample preparation techniques regarding their capability to efficiently and reproducibly recover proteins from biopsies, we present here our superior protocol for extracting proteins from low amounts of adipose tissue. Adipose tissue as a matrix in bottom-up proteomics is challenging due to the extremely high lipid content.The lysis buffer utilized contains the detergent sodium deoxycholate, which does not impair the activity of trypsin and therefore enables direct digestion without detergent removal steps...
October 5, 2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28972111/author-response-prolonged-sleep-duration-as-a-marker-of-early-neurodegeneration-predicting-incident-dementia
#10
Matthew P Pase, Andrew J Westwood, Alexa Beiser, Nikita Jain, Charles DeCarli, Jayandra J Himali, Sanford H Auerbach, Sudha Seshadri
No abstract text is available yet for this article.
October 3, 2017: Neurology
https://www.readbyqxmd.com/read/28972109/author-response-prolonged-sleep-duration-as-a-marker-of-early-neurodegeneration-predicting-incident-dementia
#11
Matthew P Pase, Sudha Seshadri
No abstract text is available yet for this article.
October 3, 2017: Neurology
https://www.readbyqxmd.com/read/28962167/effect-of-l-arginine-supplementation-on-the-hepatic-phosphatidylinositol-3-kinase-signaling-pathway-and-gluconeogenic-enzymes-in-early-intrauterine-growth-restricted-rats
#12
Kaiju Luo, Pingyang Chen, Suping Li, Wen Li, Mingfeng He, Tao Wang, Juncao Chen
The present study aimed to investigate the response of the phosphatidylinositol 3-kinase (PI3K) signaling pathway and gluconeogenic enzymes in intrauterine growth-restricted rats to dietary L-arginine (L-Arg) supplementation during the lactation period early in life. Pregnant Sprague-Dawley rats were randomly divided into a control group (CON), an intrauterine growth restriction group (IUGR) and an L-Arg group (LA). The pregnant rats in the CON group were fed a 21% protein diet, and those in the IUGR and LA groups were fed a 10% low protein diet, and all rats were fed a 21% protein diet after delivery...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28917522/does-physical-activity-change-following-hip-and-knee-replacement-matched-case-control-study-evaluating-physical-activity-scale-for-the-elderly-data-from-the-osteoarthritis-initiative
#13
T O Smith, M Mansfield, J Dainty, G Hilton, C J V Mann, C M Sackley
OBJECTIVES: To determine whether physical activity measured using the Physical Activity Scale for the Elderly (PASE), changes during the initial 24 months post-total hip (THR) or knee replacement (TKR), and how this compares to a matched non-arthroplasty cohort. DESIGN: Case-controlled study analysis of a prospectively collected dataset. SETTING: USA community-based. PARTICIPANTS: 116 people post-THR, 105 people post-TKR compared to 663 people who had not undergone THR or TKR, or had hip or knee osteoarthritis...
September 13, 2017: Physiotherapy
https://www.readbyqxmd.com/read/28915820/item-response-modeling-a-psychometric-assessment-of-the-children-s-fruit-vegetable-water-and-physical-activity-self-efficacy-scales-among-chinese-children
#14
Jing-Jing Wang, Tzu-An Chen, Tom Baranowski, Patrick W C Lau
BACKGROUND: This study aimed to evaluate the psychometric properties of four self-efficacy scales (i.e., self-efficacy for fruit (FSE), vegetable (VSE), and water (WSE) intakes, and physical activity (PASE)) and to investigate their differences in item functioning across sex, age, and body weight status groups using item response modeling (IRM) and differential item functioning (DIF). METHODS: Four self-efficacy scales were administrated to 763 Hong Kong Chinese children (55...
September 16, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/28862943/inter-relations-of-orthostatic-blood-pressure-change-aortic-stiffness-and-brain-structure-and-function-in-young-adults
#15
Leroy L Cooper, Jayandra J Himali, Alyssa Torjesen, Connie W Tsao, Alexa Beiser, Naomi M Hamburg, Charles DeCarli, Ramachandran S Vasan, Sudha Seshadri, Matthew P Pase, Gary F Mitchell
BACKGROUND: Relations of orthostatic change in blood pressure with brain structure and function have not been studied thoroughly, particularly in younger, healthier individuals. Elucidation of factors that contribute to early changes in brain integrity may lead to development of interventions that delay or prevent cognitive impairment. METHODS AND RESULTS: In a sample of the Framingham Heart Study Third Generation (N=2119; 53% women; mean age±SD, 47±8 years), we assessed orthostatic change in mean arterial pressure (MAP), aortic stiffness (carotid-femoral pulse wave velocity), neuropsychological function, and markers of subclinical brain injury on magnetic resonance imaging...
August 17, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28856821/the-proteome-of-ulcerative-colitis-in-colon-biopsies-from-adults-optimized-sample-preparation-and-comparison-with-healthy-controls
#16
Armin Schniers, Endre Anderssen, Christopher Graham Fenton, Rasmus Goll, Yvonne Pasing, Ruth Hracky Paulssen, Jon Florholmen, Terkel Hansen
PURPOSE: The purpose of the study was to optimize the sample preparation and to further use an improved sample preparation to identify proteome differences between inflamed ulcerative colitis tissue from untreated adults and healthy controls. EXPERIMENTAL DESIGN: To optimize the sample preparation, we studied the effect of adding different detergents to a urea containing lysis buffer for a Lys-C/trypsin tandem digestion. With the optimized method, we prepared clinical samples from six ulcerative colitis patients and six healthy controls and analysed them by LC-MS/MS...
August 30, 2017: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/28835407/sleep-architecture-and-the-risk-of-incident-dementia-in-the-community
#17
Matthew P Pase, Jayandra J Himali, Natalie A Grima, Alexa S Beiser, Claudia L Satizabal, Hugo J Aparicio, Robert J Thomas, Daniel J Gottlieb, Sandford H Auerbach, Sudha Seshadri
OBJECTIVE: Sleep disturbance is common in dementia, although it is unclear whether differences in sleep architecture precede dementia onset. We examined the associations between sleep architecture and the prospective risk of incident dementia in the community-based Framingham Heart Study (FHS). METHODS: Our sample comprised a subset of 321 FHS Offspring participants who participated in the Sleep Heart Health Study between 1995 and 1998 and who were aged over 60 years at the time of sleep assessment (mean age 67 ± 5 years, 50% male)...
September 19, 2017: Neurology
https://www.readbyqxmd.com/read/28820755/sleep-complications-following-traumatic-brain-injury
#18
Natalie A Grima, Jennie L Ponsford, Matthew P Pase
PURPOSE OF REVIEW: Recent research has provided extensive characterization as to the frequency and nature of sleep disturbances following traumatic brain injury (TBI). This review summarizes the current state of knowledge and proposes future directions for research. RECENT FINDINGS: Complaints of sleep disturbance are common following TBI, and objective assessments of sleep largely corroborate these complaints. Sleep is often disturbed in the acute phase postinjury and can persist for decades, with the prevalence of sleep disorders higher in patients with TBI as compared with the general population...
August 17, 2017: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/28805508/corrigendum-to-effectiveness-of-a-multidimensional-web-based-intervention-program-to-change-brazilian-health-practitioners-attitudes-toward-the-lesbian-gay-bisexual-and-transgender-population
#19
Angelo Brandelli Costa, Paola Fagundes Pase, Eric Seger de Camargo, Camila Guaranha, Adriano Henrique Caetano, Daniel Kveller, Heitor Thomé da Rosa Filho, Ramiro Figueiredo Catelan, Silvia Helena Koller, Henrique Caetano Nardi
Corrigendum to: J Health Psychol DOI 10.1177/1359105316628748 Unfortunately, the online published article has an error in one of the analyses. On page 365, fifth paragraph, the corrected statistical report is (Δ 1.66, 95% CI [3.32, .01], t (305) = -1.98, p<.05), not (Δ 1.66, 95% CI [3.32, .01], t (305) = -1.66, p <.05). In spite of this correction, there is no change in the direction of the test and therefore in the interpretation of this result.
June 2017: Journal of Health Psychology
https://www.readbyqxmd.com/read/28800755/the-influence-of-3%C3%A2-months-of-physical-exercises-and-verbal-stimulation-on-functional-efficiency-and-use-of-free-time-in-an-older-population-under-institutional-care-study-protocol-for-a-randomized-controlled-trial
#20
Agnieszka Wiśniowska-Szurlej, Agnieszka Ćwirlej-Sozańska, Anna Wilmowska-Pietruszyńska, Natalia Milewska, Bernard Sozański
BACKGROUND: In recent years, there has been a significant change in the demographics of developed countries, including an increase in the number of older people. This aging population and the associated need for medical care and assistance places great strain on health care systems worldwide. In older populations, improved knowledge and understanding of the relationship between moderate exercise and health might result in greater motivation to engage in such activity; thus improving the overall health of this population...
August 11, 2017: Trials
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