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https://www.readbyqxmd.com/read/29924185/evaluation-of-systemic-inflammation-in-patients-being-weaned-from-mechanical-ventilation
#1
Soraia Genebra Ibrahim Forgiarini, Darlan Pase da Rosa, Luiz Felipe Forgiarini, Cassiano Teixeira, Cristiano Feijó Andrade, Luiz Alberto Forgiarini Junior, Elaine Aparecida Felix, Gilberto Friedman
OBJECTIVES: The aim of this study was to evaluate systemic inflammatory factors and their relation to success or failure in a spontaneous ventilation test. METHODS: This cross-sectional study included a sample of 54 adult patients. Demographic data and clinical parameters were collected, and blood samples were collected in the first minute of the spontaneous ventilation test to evaluate interleukin (IL)-1β, IL-6, IL-8, and IL-10, tumour necrosis factor alpha (TNFα) and C-reactive protein...
2018: Clinics
https://www.readbyqxmd.com/read/29898998/operational-performance-of-a-plasmodium-falciparum-ultrasensitive-rapid-diagnostic-test-for-the-detection-of-asymptomatic-infections-in-eastern-myanmar
#2
Jordi Landier, Warat Haohankhunnatham, Smita Das, Kamonchanok Konghahong, Peter Christensen, Jathee Raksuansak, Pase Phattharakokoedbun, Ladda Kajeechiwa, May Myo Thwin, Ihn Kyung Jang, Mallika Imwong, Jacher Wiladphaingern, Khin Maung Lwin, Clare Ling, Stephane Proux, Gonzalo J Domingo, Gilles Delmas, François H Nosten
Context In the Greater Mekong Subregion, malaria elimination strategies target all Plasmodium falciparum parasites, including those carried asymptomatically. Over 70% of asymptomatic carriers are undetectable by current rapid diagnostic tests (RDT) or microscopy. An HRP2-based ultrasensitive RDT (uRDT) developed to improve the detection of low density infections was evaluated during prevalence surveys within a malaria elimination program in a low transmission area of Eastern Myanmar. Methods Surveys were conducted to identify high prevalence villages...
June 13, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29893610/associations-between-sedentary-behavior-physical-activity-and-out-of-pocket-health-care-expenditure-evidence-from-chinese-older-adults
#3
Hongjun Yu, Andiara Schwingel
OBJECTIVE: This study examined the associations between sedentary behavior, physical activity, and health care expenditures among Chinese older adults. METHOD: We conducted a survey on 4,165 older men and women living in major cities in China. Sedentary behavior and physical activity were measured by the Physical Activity Scale for the Elderly (PASE) questionnaire. Healthcare costs were assessed by self-reported out-of-pocket health care expenditures across outpatient care, inpatient care, medication, and formal caregiver expenses...
June 12, 2018: Journal of Aging and Physical Activity
https://www.readbyqxmd.com/read/29883484/macrophages-protect-talaromyces-marneffei-conidia-from-myeloperoxidase-dependent-neutrophil-fungicidal-activity-during-infection-establishment-in-vivo
#4
Felix Ellett, Vahid Pazhakh, Luke Pase, Erica L Benard, Harshini Weerasinghe, Denis Azabdaftari, Sultan Alasmari, Alex Andrianopoulos, Graham J Lieschke
Neutrophils and macrophages provide the first line of cellular defence against pathogens once physical barriers are breached, but can play very different roles for each specific pathogen. This is particularly so for fungal pathogens, which can occupy several niches in the host. We developed an infection model of talaromycosis in zebrafish embryos with the thermally-dimorphic intracellular fungal pathogen Talaromyces marneffei and used it to define different roles of neutrophils and macrophages in infection establishment...
June 8, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29788252/translation-the-universal-structural-core-of-life
#5
Chad R Bernier, Anton S Petrov, Nicholas A Kovacs, Petar Penev, Loren Dean Williams
The Universal Gene Set of Life (UGSL) is common to genomes of all extant organisms. The UGSL is small, consisting of less than 100 genes, and is dominated by genes encoding the translation system. Here we extend the search for biological universality to three dimensions. We characterize and quantitate the universality of structure of macromolecules that are common to all of life. We determine that around 90% of prokaryotic rRNA forms a common core, which are the structural and functional foundation of rRNAs of all cytoplasmic ribosomes...
May 21, 2018: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/29785635/self-monitoring-physical-activity-with-a-smartphone-application-in-cancer-patients-a-randomized-feasibility-study-smart-trial
#6
Harm L Ormel, Gabriela G F van der Schoot, Nico-Derk L Westerink, Wim J Sluiter, Jourik A Gietema, Annemiek M E Walenkamp
PURPOSE: Evidence accumulates that an active lifestyle positively influences cancer treatment outcome. A "smartphone application" (app) such as "RunKeeper," to self-monitor physical activity (PA) might be helpful. This study aimed to examine whether using RunKeeper to increase self-reported PA is feasible in cancer patients and to evaluate patients' opinion about using RunKeeper in a 12-week program. METHODS: Adult patients (n = 32), diagnosed with cancer, were randomized between usual care (n = 16) or a 12-week intervention with instructions to self-monitor PA with RunKeeper (n = 16)...
May 21, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29716737/development-and-optimization-of-a-plunger-assisted-solvent-extraction-method-for-polycyclic-aromatic-hydrocarbons-sampled-onto-multi-channel-silicone-rubber-traps
#7
Chiedza F Munyeza, Onkarabile Dikale, Egmont R Rohwer, Patricia B C Forbes
A plunger assisted solvent extraction (PASE) method for multi-channel silicone rubber trap samplers was developed and evaluated as an alternative to direct thermal desorption for the monitoring of polycyclic aromatic hydrocarbons (PAHs). The proposed extraction method was simple, fast (a total of 2 min for extraction), and used a small volume of solvent (a total of 2 mL from two sequential 1 mL extractions). The PASE method presented an advantage over thermal desorption in that samples could be re-analyzed, as only a portion of the extract was injected...
April 23, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29593384/cross-cultural-adaptation-and-validation-of-the-arabic-version-of-the-physical-activity-scale-for-the-elderly-among-community-dwelling-older-adults-in-saudi-arabia
#8
Ayidh M Alqarni, Vishal Vennu, Sulaiman A Alshammari, Saad M Bindawas
Purpose: Older adults are the fastest growing population group worldwide. Regular physical activity (PA) is reported to reduce the risk of health conditions and improve personal well-being. Few validated instruments can be used to measure the PA levels among older adults in Saudi Arabia. The Physical Activity Scale for the Elderly (PASE) is used worldwide for evaluating the PA levels of the elderly in epidemiological studies. However, this scale has not been translated into Arabic. This study aimed to cross-culturally adapt the PASE into Arabic language and evaluate its reliability and validity among community-dwelling older adults in Saudi Arabia...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29529273/the-association-between-trajectories-of-physical-activity-and-all-cause-and-cause-specific-mortality
#9
Deepika Laddu, Neeta Parimi, Jane A Cauley, Peggy M Cawthon, Kristine E Ensrud, Eric Orwoll, Marcia Stefanick, Lisa Langsetmo
Background: The benefits of physical activity (PA) for health have primarily been evaluated during midlife. Whether patterns of change in late-life PA associate with overall and cause-specific mortality remains unclear. Methods: We examined the association between PA trajectories and subsequent mortality among 3,767 men aged ≥ 65 years. Men self-reported PA using the Physical Activity Scale for the Elderly scale (PASE) at up to 4 time points from 2000 through 2009 (Year 7); mortality was assessed over an average of 7...
February 26, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29507137/author-response-sleep-architecture-and-the-risk-of-incident-dementia-in-the-community
#10
Matthew P Pase, Jayandra J Himali, Natalie A Grima, Alexa S Beiser, Claudia L Satizabal, Hugo J Aparicio, Robert J Thomas, Daniel J Gottlieb, Sanford H Auerbach, Sudha Seshadri
No abstract text is available yet for this article.
March 6, 2018: Neurology
https://www.readbyqxmd.com/read/29499895/-characteristics-present-in-secondary-school-students-who-do-not-smoke-and-who-have-no-intention-to-smoke
#11
Marta Lima-Serrano, José Manuel Martínez-Montilla, Ana Magdalena Vargas-Martínez, José Antonio Zafra-Agea, Joaquín Salvador Lima-Rodríguez
OBJECTIVE: To know the variables present in primary and secondary school students who do not smoke or intend to smoke from a positive health model. METHODS: Cross-sectional study with 482 students from Andalusia and Catalonia using a validated questionnaire (ESFA and PASE project). Binary logistic regression analysis was performed. RESULTS: Those who did not intend to smoke viewed smoking unfavourably and had high self-efficacy (p <0.001)...
February 27, 2018: Gaceta Sanitaria
https://www.readbyqxmd.com/read/29487746/impact-of-exercise-counseling-on-physical-function-in-chronic-kidney-disease-an-observational-study
#12
Clara J Bohm, Leroy J Storsley, Brett M Hiebert, Serena Nelko, Navdeep Tangri, Lawrence J Cheskin, Mara A McAdams-DeMarco, Claudio Rigatto
Background: Individuals with chronic kidney disease (CKD) have low levels of physical activity and physical function. Although guidelines endorse exercise counseling for individuals with CKD, it is not yet part of routine care. Objective: We investigated the effect of attending a real-life exercise counseling clinic (ECC) on physical function in individuals with CKD. Design: Retrospective analysis of prospectively collected observational data with quasi-experimental design...
2018: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/29474961/the-presence-of-glutamate-residues-on-the-pas-sequence-of-the-stimuli-sensitive-nano-ferritin-improves-in-vivo-biodistribution-and-mitoxantrone-encapsulation-homogeneity
#13
Elisabetta Falvo, Francesca Malagrinò, Alessandro Arcovito, Francesco Fazi, Gianni Colotti, Elisa Tremante, Patrizio Di Micco, Aldo Braca, Roberta Opri, Alessandro Giuffrè, Giulio Fracasso, Pierpaolo Ceci
A genetically engineered human ferritin heavy chain (HFt)-based construct has been recently shown by our group to efficiently entrap and deliver doxorubicin to cancer cells. This construct, named HFt-MP-PAS, contained a tumor-selective sequence (MP) responsive to proteolytic cleavage by tumor proteases (MMPs), located between each HFt subunit and an outer shielding polypeptide sequence rich in proline (P), serine (S) and alanine (A) residues (PAS). HFt-MP-PAS displayed excellent therapeutic efficacy in xenogenic pancreatic and head and neck cancer models in vivo, leading to a significant increase in overall animal survivals...
April 10, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29454336/change-in-physical-activity-level-and-clinical-outcomes-in-older-adults-with-knee-pain-a-secondary-analysis-from-a-randomised-controlled-trial
#14
Jonathan G Quicke, Nadine E Foster, Peter R Croft, Reuben O Ogollah, Melanie A Holden
BACKGROUND: Exercise interventions improve clinical outcomes of pain and function in adults with knee pain due to osteoarthritis and higher levels of physical activity are associated with lower severity of pain and higher levels of physical functioning in older adults with knee osteoarthritis in cross-sectional studies. However, to date no studies have investigated if change in physical activity level during exercise interventions can explain clinical outcomes of pain and function. This study aimed to investigate if change in physical activity during exercise interventions is associated with future pain and physical function in older adults with knee pain...
February 17, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29430733/the-relationship-between-clinical-characteristics-including-presence-of-exposed-lesions-and-health-related-quality-of-life-hrqol-in-patients-with-psoriasis-analysis-from-the-nationwide-epidemiologic-study-for-psoriasis-in-korea-epi-psode-study
#15
S W Youn, J-H Lee, D Y Yu, Y Kim, B S Kim, S J Seo, Y B Choe, S-K Yun, J Park, N I Kim, C W Choi, J I Youn, S-J Lee, M-G Lee, K J Kim, C J Park, Y S Ro, H J Song, B S Shin, S K Ahn, J Y Lee, Y H Won, M S Jang, K H Kim, M H Kim, T Y Kim, J-H Choi
BACKGROUND: Psychological aspect and quality of life should be considered in treating patients with psoriasis. OBJECTIVE: We sought to ascertain which clinical characteristics including presence of exposed lesions are associated with impairment of health-related quality of life (HRQoL) in patients with psoriasis. METHODS: The EPI-PSODE study was a nationwide, multicenter, cross-sectional study conducted in Korea that included 1260 adult patients with psoriasis...
February 11, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29317381/using-social-media-for-the-promotion-of-education-and-consultation-in-adolescents-who-have-undergone-kidney-transplant-protocol-for-a-randomized-control-trial
#16
Claudiana Pase, Andréia Dias Mathias, Clotilde Druck Garcia, Clarissa Garcia Rodrigues
BACKGROUND: Falling ill represents a traumatic experience especially in adolescence, since in addition to the moments of ambiguity and contradictions that this period brings, there is coping with the disease. Renal transplantation provides a better quality of life but the dependence on dialysis is replaced by the greater responsibility of self-care. With advances in technology, contemporary communication methods are a strategic mechanism for the approximation of the adolescent and the multiprofessional team...
January 9, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29305881/liver-carbohydrates-metabolism-a-new-islet-neogenesis-associated-protein-peptide-ingap-pp-target
#17
Hernán Gonzalo Villagarcía, Carolina Lisi Román, María Cecilia Castro, Luisa Arbeláez González, María Teresa Ronco, Daniel Eleazar Francés, María Laura Massa, Bárbara Maiztegui, Luis Emilio Flores, Juan José Gagliardino, Flavio Francini
Islet-Neogenesis Associated Protein-Pentadecapeptide (INGAP-PP) increases β-cell mass and enhances glucose and amino acids-induced insulin secretion. Our aim was to demonstrate its effect on liver metabolism. For that purpose, adult male Wistar rats were injected twice-daily (10 days) with saline solution or INGAP-PP (250 μg). Thereafter, serum glucose, triglyceride and insulin levels were measured and homeostasis model assessment (HOMA-IR) and hepatic insulin sensitivity (HIS) were determined. Liver glucokinase and glucose-6-phosphatase (G-6-Pase) expression and activity, phosphoenolpyruvate carboxykinase (PEPCK) expression, phosphofructokinase-2 (PFK-2) protein content, P-Akt/Akt and glycogen synthase kinase-3β (P-GSK3/GSK3) protein ratios and glycogen deposit were also determined...
March 2018: Peptides
https://www.readbyqxmd.com/read/29304778/inflammation-and-glucose-homeostasis-are-associated-with-specific-structural-features-among-adults-without-knee-osteoarthritis-a-cross-sectional-study-from-the-osteoarthritis-initiative
#18
Alina C Stout, Mary F Barbe, Charles B Eaton, Mamta Amin, Fatimah Al-Eid, Lori Lyn Price, Bing Lu, Grace H Lo, Ming Zhang, Jincheng Pang, Timothy E McAlindon, Jeffrey B Driban
BACKGROUND: Greater age and body mass index are strong risk factors for osteoarthritis (OA). Older and overweight individuals may be more susceptible to OA because these factors alter tissue turnover in menisci, articular cartilage, and bone via altered glucose homeostasis and inflammation. Understanding the role of inflammation and glucose homeostasis on structural features of early-stage OA may help identify therapeutic targets to delay or prevent the onset of OA among subsets of adults with these features...
January 5, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29299789/hiv-related-healthcare-needs-and-access-barriers-for-brazilian-transgender-and-gender-diverse-people
#19
Angelo Brandelli Costa, Anna Martha Vaitses Fontanari, Ramiro Figueiredo Catelan, Karine Schwarz, Juliana Ledur Stucky, Heitor Tome da Rosa Filho, Paola Fagundes Pase, Daniel Augusto Mori Gagliotti, Alexandre Saadeh, Maria Inês Rodrigues Lobato, Henrique Caetano Nardi, Silvia Helena Koller
The aim of this study is to investigate HIV-related healthcare needs and access barriers for Brazilian transgender and gender diverse people. Data were collected from gender identity clinics and the questionnaire was also made available on the Internet. Out of the 543 participants-62.1% (n = 337) transgender women, 28.7 (n = 156) transgender men and 9.2% (n = 50) gender diverse people, 63.7% had been tested at least once in their lives. The prevalence of self-reported HIV-positive status among transgender women was 16...
January 3, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29288178/pilot-for-the-australian-breast-device-registry-abdr-a-national-opt-out-clinical-quality-registry-for-breast-device-surgery
#20
Ingrid Hopper, Renee L Best, John J McNeil, Catherine M Mulvany, Colin C M Moore, Elisabeth Elder, Marie Pase, Rodney D Cooter, Sue M Evans
PURPOSE: To establish a pilot clinical quality registry (CQR) to monitor the quality of care and device performance for breast device surgery in Australia. PARTICIPANTS: All patients having breast device surgery from contributing hospitals in Australia. A literature review was performed which identified quality indicators for breast device surgery. FINDINGS TO DATE: A pilot CQR was established in 2011 to capture prospective data on breast device surgery...
December 28, 2017: BMJ Open
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