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https://www.readbyqxmd.com/read/28473633/aortic-stiffness-increased-white-matter-free-water-and-altered-microstructural-integrity-a-continuum-of-injury
#1
Pauline Maillard, Gary F Mitchell, Jayandra J Himali, Alexa Beiser, Evan Fletcher, Connie W Tsao, Matthew P Pase, Claudia L Satizabal, Ramachandran S Vasan, Sudha Seshadri, Charles DeCarli
BACKGROUND AND PURPOSE: Previous reports from the Framingham Heart Study have identified cross-sectional associations of arterial stiffness, as reflected by carotid-femoral pulse wave velocity (CFPWV) and systolic blood pressure with vascular brain injury. The purpose of this study is to examine free water (FW), fractional anisotropy (FA), and white matter hyperintensities (WMH) in relation to arterial stiffness among subjects of the Framingham Offspring and Third-Generation cohorts. METHODS: In 2422 participants aged 51...
May 4, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28428346/sugar-and-artificially-sweetened-beverages-and-the-risks-of-incident-stroke-and-dementia-a-prospective-cohort-study
#2
Matthew P Pase, Jayandra J Himali, Alexa S Beiser, Hugo J Aparicio, Claudia L Satizabal, Ramachandran S Vasan, Sudha Seshadri, Paul F Jacques
BACKGROUND AND PURPOSE: Sugar- and artificially-sweetened beverage intake have been linked to cardiometabolic risk factors, which increase the risk of cerebrovascular disease and dementia. We examined whether sugar- or artificially sweetened beverage consumption was associated with the prospective risks of incident stroke or dementia in the community-based Framingham Heart Study Offspring cohort. METHODS: We studied 2888 participants aged >45 years for incident stroke (mean age 62 [SD, 9] years; 45% men) and 1484 participants aged >60 years for incident dementia (mean age 69 [SD, 6] years; 46% men)...
May 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28420169/ultrasensitive-label-free-sensing-of-il-6-based-on-pase-functionalized-carbon-nanotube-micro-arrays-with-rna-aptamers-as-molecular-recognition-elements
#3
Farhad Khosravi, Seyed Masoud Loeian, Balaji Panchapakesan
This study demonstrates the rapid and label-free detection of Interleukin-6 (IL-6) using carbon nanotube micro-arrays with aptamer as the molecular recognition element. Single wall carbon nanotubes micro-arrays biosensors were manufactured using photo-lithography, metal deposition, and etching techniques. Nanotube biosensors were functionalized with 1-Pyrenebutanoic Acid Succinimidyl Ester (PASE) conjugated IL-6 aptamers. Real time response of the sensor conductance was monitored with increasing concentration of IL-6 (1 pg/mL to 10 ng/mL), exposure to the sensing surface in buffer solution, and clinically relevant spiked blood samples...
April 17, 2017: Biosensors
https://www.readbyqxmd.com/read/28382966/the-pu-1-target-gene-zbtb11-regulates-neutrophil-development-through-its-integrase-like-hhcc-zinc-finger
#4
Maria-Cristina Keightley, Duncan P Carradice, Judith E Layton, Luke Pase, Julien Y Bertrand, Johannes G Wittig, Aleksandar Dakic, Andrew P Badrock, Nicholas J Cole, David Traver, Stephen L Nutt, Julia McCoey, Ashley M Buckle, Joan K Heath, Graham J Lieschke
In response to infection and injury, the neutrophil population rapidly expands and then quickly re-establishes the basal state when inflammation resolves. The exact pathways governing neutrophil/macrophage lineage outputs from a common granulocyte-macrophage progenitor are still not completely understood. From a forward genetic screen in zebrafish, we identify the transcriptional repressor, ZBTB11, as critical for basal and emergency granulopoiesis. ZBTB11 sits in a pathway directly downstream of master myeloid regulators including PU...
April 6, 2017: Nature Communications
https://www.readbyqxmd.com/read/28330721/changes-in-the-human-transcriptome-upon-vitamin-d-supplementation
#5
Yvonne Pasing, Christopher Graham Fenton, Rolf Jorde, Ruth Hracky Paulssen
Vitamin D is hydroxylated in the liver and kidneys to its active form, which can bind to the vitamin D receptor (VDR). The VDR is present in a wide variety of different cells types and tissues and acts as a transcription factor. Although activation of the VDR is estimated to regulate expression of up to 5% of the human genome, our study is the first analysing gene expression after supplementation in more than 10 subjects. Subjects of a randomized controlled trial (RCT) received either vitamin D3 (n47) in a weekly dose of 20,000 IU or placebo (n 47) for a period of three to five years...
March 19, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28274718/sugary-beverage-intake-and-preclinical-alzheimer-s-disease-in-the-community
#6
Matthew P Pase, Jayandra J Himali, Paul F Jacques, Charles DeCarli, Claudia L Satizabal, Hugo Aparicio, Ramachandran S Vasan, Alexa S Beiser, Sudha Seshadri
INTRODUCTION: Excess sugar consumption has been linked with Alzheimer's disease (AD) pathology in animal models. METHODS: We examined the cross-sectional association of sugary beverage consumption with neuropsychological (N = 4276) and magnetic resonance imaging (N = 3846) markers of preclinical Alzheimer's disease and vascular brain injury (VBI) in the community-based Framingham Heart Study. Intake of sugary beverages was estimated using a food frequency questionnaire...
March 6, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28269052/effect-of-oral-glucose-supplementation-on-surface-emg-during-fatiguing-dynamic-exercise
#7
Clare M Davidson, Giuseppe De Vito, Madeleine M Lowery
The aim of this study was to examine the effect of oral glucose supplementation on the surface electromyographic (sEMG) signal recorded during a dynamic, fatiguing exercise protocol. Five healthy subjects participated in the study. Blood glucose concentration and sEMG signals from five upper leg muscles were recorded during a cycling exercise performed at 70% VO2peak until task failure, on two separate occasions. Glucose was consumed at 15 minute intervals throughout one trial. The median frequency of the sEMG was observed to increase progressively throughout the exercise, with a greater increase in the with glucose condition...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28238574/could-hypoxia-acclimation-cause-morphological-changes-and-protect-against-mn-induced-oxidative-injuries-in-silver-catfish-rhamdia-quelen-even-after-reoxygenation
#8
G S Dolci, H Z Rosa, L T Vey, C S Pase, R C S Barcelos, V T Dias, L Loebens, P Dalla Vecchia, C A Bizzi, B Baldisserotto, M E Burger
Exposure to hypoxia has shown beneficial adjustments in different species, including silver catfish (Rhamdia quelen), especially in situations of aquatic contamination with pollutants such as manganese (Mn). Considering that hypoxia is seasonal in the natural aquatic environment, we decided to assess whether these adaptive mechanisms could be maintained when reoxygenation is established. Silver catfish acclimated to moderate hypoxia (∼3 mg L(-1), 41% O2 saturation) for 10 days and subsequently exposed to Mn (∼8...
February 23, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28228567/prolonged-sleep-duration-as-a-marker-of-early-neurodegeneration-predicting-incident-dementia
#9
Andrew J Westwood, Alexa Beiser, Nikita Jain, Jayandra J Himali, Charles DeCarli, Sanford H Auerbach, Matthew P Pase, Sudha Seshadri
OBJECTIVE: To evaluate the association between sleep duration and the risk of incident dementia and brain aging. METHODS: Self-reported total hours of sleep were examined in the Framingham Heart Study (n = 2,457, mean age 72 ± 6 years, 57% women) as a 3-level variable: <6 hours (short), 6-9 hours (reference), and >9 hours (long), and was related to the risk of incident dementia over 10 years, and cross-sectionally to total cerebral brain volume (TCBV) and cognitive performance...
March 21, 2017: Neurology
https://www.readbyqxmd.com/read/28227269/effect-of-oral-glucose-supplementation-on-surface-emg-during-fatiguing-dynamic-exercise
#10
Clare M Davidson, Giuseppe De Vito, Madeleine M Lowery, Clare M Davidson, Giuseppe De Vito, Madeleine M Lowery, Madeleine M Lowery, Giuseppe De Vito, Clare M Davidson
The aim of this study was to examine the effect of oral glucose supplementation on the surface electromyographic (sEMG) signal recorded during a dynamic, fatiguing exercise protocol. Five healthy subjects participated in the study. Blood glucose concentration and sEMG signals from five upper leg muscles were recorded during a cycling exercise performed at 70% VO2peak until task failure, on two separate occasions. Glucose was consumed at 15 minute intervals throughout one trial. The median frequency of the sEMG was observed to increase progressively throughout the exercise, with a greater increase in the with glucose condition...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28185297/physical-activity-in-solid-organ-transplant-recipients-participation-predictors-barriers-and-facilitators
#11
Tanya Gustaw, Emma Schoo, Colleen Barbalinardo, Nicole Rodrigues, Yalda Zameni, Vinícius Nogueira Motta, Sunita Mathur, Tania Janaudis-Ferreira
BACKGROUND: Our objectives were to describe the physical activity (PA) levels, predictors, barriers, and facilitators to PA in solid organ transplant (SOT) recipients. METHODS: A web-based questionnaire was sent to members of the Canadian Transplant Association including the Physical Activity Scale for the Elderly (PASE), and questions regarding barriers and facilitators of PA. RESULTS: One hundred and thirteen SOT recipients completed the survey...
April 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28154108/contextual-correlates-of-physical-activity-among-older-adults-a-neighborhood-environment-wide-association-study-ne-was
#12
EDITORIAL
Stephen J Mooney, Spruha Joshi, Magdalena Cerdá, Gary J Kennedy, John R Beard, Andrew G Rundle
Background: Few older adults achieve recommended physical activity levels. We conducted a "neighborhood environment-wide association study (NE-WAS)" of neighborhood influences on physical activity among older adults, analogous, in a genetic context, to a genome-wide association study.Methods: Physical Activity Scale for the Elderly (PASE) and sociodemographic data were collected via telephone survey of 3,497 residents of New York City aged 65 to 75 years. Using Geographic Information Systems, we created 337 variables describing each participant's residential neighborhood's built, social, and economic context...
April 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28108872/neighborhood-disorder-and-physical-activity-among-older-adults-a-longitudinal-study
#13
Stephen J Mooney, Spruha Joshi, Magdalena Cerdá, Gary J Kennedy, John R Beard, Andrew G Rundle
Neighborhood physical disorder-the visual indications of neighborhood deterioration-may inhibit outdoor physical activity, particularly among older adults. However, few previous studies of the association between neighborhood disorder and physical activity have focused on this sensitive population group, and most have been cross-sectional. We examined the relationship between neighborhood physical disorder and physical activity, measured using the Physical Activity Scale for the Elderly (PASE), in a three-wave longitudinal study of 3497 New York City residents aged 65-75 at baseline weighted to be representative of the older adult population of New York City...
February 2017: Journal of Urban Health: Bulletin of the New York Academy of Medicine
https://www.readbyqxmd.com/read/28095473/the-asymmetric-cell-division-regulators-par3-scribble-and-pins-gpsm2-are-not-essential-for-erythroid-development-or-enucleation
#14
Christina B Wölwer, Nathan Gödde, Luke B Pase, Imogen A Elsum, Krystle Y B Lim, Faruk Sacirbegovic, Carl R Walkley, Sarah Ellis, Shigeo Ohno, Fumio Matsuzaki, Sarah M Russell, Patrick O Humbert
Erythroid enucleation is the process by which the future red blood cell disposes of its nucleus prior to entering the blood stream. This key event during red blood cell development has been likened to an asymmetric cell division (ACD), by which the enucleating erythroblast divides into two very different daughter cells of alternate molecular composition, a nucleated cell that will be removed by associated macrophages, and the reticulocyte that will mature to the definitive erythrocyte. Here we investigated gene expression of members of the Par, Scribble and Pins/Gpsm2 asymmetric cell division complexes in erythroid cells, and functionally tested their role in erythroid enucleation in vivo and ex vivo...
2017: PloS One
https://www.readbyqxmd.com/read/28089435/jejunal-gluconeogenesis-associated-with-insulin-resistance-level-and-its-evolution-after-roux-en-y-gastric-bypass
#15
Carolina Gutierrez-Repiso, Sara Garcia-Serrano, Francisco J Moreno-Ruiz, Guillermo Alcain-Martinez, Francisca Rodriguez-Pacheco, Eduardo Garcia-Fuentes
BACKGROUND: Intestinal gluconeogenesis (GNG) may play an important role in glucose homeostasis, but there is little information about the condition in humans. OBJECTIVES: To study the relationship between intestinal GNG and insulin resistance, its association with the evolution of morbidly obese patients after bariatric surgery, and the effect of insulin and or leptin. SETTING: Regional university hospital, Malaga (Spain). METHODS: Jejunal mRNA expression of genes involved in GNG was analyzed in 3 groups of morbidly obese patients who underwent Roux-en-Y gastric bypass: with low insulin resistance (MO-low-IR), with high insulin resistance (MO-high-IR), and with type 2 diabetes treated with metformin (MO-metf-T2D)...
April 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28053520/psychometric-properties-of-the-physical-activity-scale-for-the-elderly-in-chinese-patients-with-copd
#16
Yan-Xia Tao, Lan Wang, Xiao-Yan Dong, Hong Zheng, Ya-Shu Zheng, Xing-Yue Tang, Yue Zhao, Qing Zhang
BACKGROUND: For patients with COPD, physical activity (PA) is recommended as the core component of pulmonary rehabilitation, but there is lack of a validated questionnaire for assessing the PA effectively. AIM: To evaluate the reliability and validity of the Chinese version of Physical Activity Scale for the Elderly (PASE-C) in patients with COPD. METHODS: A cross-sectional study was conducted with 167 outpatients aged 60 years or older with COPD...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28013202/performance-of-screening-tools-for-psoriatic-arthritis-a-cross-sectional-study-in-primary-care
#17
Maren C Karreman, Angelique E A M Weel, Myrthe van der Ven, Marijn Vis, Ilja Tchetverikov, Tamar E C Nijsten, Marlies Wakkee, Johanna M W Hazes, Jolanda J Luime
Objective: . To compare the screening performance of the Psoriasis Epidemiology Screening Tool (PEST), Psoriatic Arthritis Screening and Evaluation (PASE) and Early Arthritis for Psoriatic Patients (EARP) questionnaires for detecting PsA among psoriasis patients in a primary care setting. Methods.: In a cross-sectional study, 473 primary care psoriasis patients at risk for PsA completed the PEST, PASE and EARP questionnaires and were clinically evaluated by a trained research nurse...
April 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/27981025/long-term-effects-of-a-weight-loss-intervention-with-or-without-exercise-component-in-postmenopausal-women-a-randomized-trial
#18
Martijn de Roon, Willemijn A van Gemert, Petra H Peeters, Albertine J Schuit, Evelyn M Monninkhof
The aim of this study was to determine the long-term effects of a weight loss intervention with or without an exercise component on body weight and physical activity. Women were randomized to diet (n = 97) or exercise (N = 98) for 16 weeks. During the intervention, both groups had achieved the set goal of 5-6 kg weight loss. All women were re-contacted twelve months after study cessation for follow-up where body weight and physical activity were measured (PASE questionnaire and ActiGraph accelerometer)...
March 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/27938474/muse-cells-nontumorigenic-pluripotent-like-stem-cells-have-liver-regeneration-capacity-through-specific-homing-and-cell-replacement-in-a-mouse-model-of-liver-fibrosis
#19
Masahiro Iseki, Yoshihiro Kushida, Shohei Wakao, Takahiro Akimoto, Masamichi Mizuma, Fuyuhiko Motoi, Ryuta Asada, Shinobu Shimizu, Michiaki Unno, Gregorio Chazenbalk, Mari Dezawa
Muse cells, a novel type of nontumorigenic pluripotent-like stem cells, reside in the bone marrow, skin, and adipose tissue and are collectable as cells positive for pluripotent surface marker SSEA-3. They are able to differentiate into cells representative of all three germ layers. The capacity of intravenously injected human bone marrow-derived Muse cells to repair an immunodeficient mouse model of liver fibrosis was evaluated in this study. The cells exhibited the ability to spontaneously differentiate into hepatoblast/hepatocyte lineage cells in vitro...
May 9, 2017: Cell Transplantation
https://www.readbyqxmd.com/read/27924167/reduction-of-falls-and-factors-affecting-falls-a-year-after-total-knee-arthroplasty-in-elderly-patients-with-severe-knee-osteoarthritis
#20
T Tsonga, M Michalopoulou, S Kapetanakis, E Giovannopoulou, P Malliou, G Godolias, P Soucacos
BACKGROUND: Total Knee Arthroplasty (TKA) is a common surgical treatment for severe knee Osteoarthritis (OA), which generally improves pain, physical function, quality of life and possibly fall risk. Fall risk increases for older adults with severe knee OA; however it has not been studied extensively whether this parameter is improved after TKA. OBJECTIVE: To investigate: a) the history and frequency of falls, including mechanism or causes of falls, injuries sustained from falls reported, activity during falling and location of falls and, b) the factors affecting falls, a year after TKA in elderly patients with severe knee OA...
2016: Open Orthopaedics Journal
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