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https://www.readbyqxmd.com/read/29331464/somatic-cell-count-based-selection-reduces-susceptibility-to-energy-shortage-during-early-lactation-in-a-sheep-model
#1
J Bouvier-Muller, C Allain, F Enjalbert, Y Farizon, D Portes, G Foucras, R Rupp
During the transition from late gestation to early lactation ruminants experience a negative energy balance (NEB), which is considered to increase susceptibility to mammary infections. Our previous study in 2 divergent lines of sheep selected for high and low somatic cell score (SCS) suggested an association between the response to NEB and genetic susceptibility to mastitis. Forty-eight early-lactation primiparous dairy ewes from the 2 SCS genetic lines were allocated to 2 homogeneous subgroups-an NEB group, which was energy restricted and received 60% of the energy requirements for 15 d, and a control-fed group-to obtain 4 balanced groups of 12 ewes: high-SCS positive energy balance, low-SCS positive energy balance, high-SCS NEB, and low-SCS NEB...
January 10, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29329698/effect-of-combined-exercise-training-on-serum-brain-derived-neurotrophic-factor-suppressors-of-cytokine-signaling-1-and-3-in-patients-with-multiple-sclerosis
#2
C Ozkul, A Guclu-Gunduz, C Irkec, I Fidan, Y Aydin, T Ozkan, G Yazici
BACKGROUND: Suppressors of cytokine signaling (SOCS) and brain-derived neurotrophic factor (BDNF) are important immunologic, and neurotrophic factors for MS pathogenesis. The impact of exercise on these factors is yet to be fully elucidated in patients with MS. OBJECTIVE: The primary aim of this study is to investigate the effect of 8-week combined exercise training on serum concentrations of SOCS1, SOCS3, and BDNF. The secondary aim is to determine the effects of combined exercise training on balance, functional exercise capacity, and fatigue in patients with MS...
January 3, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29325345/-important-issues-need-to-be-emphasized-in-the-diagnosis-and-treatment-of-pancreatic-cystic-neoplasms
#3
W H Lou, Y P Zhao
The patients of pancreatic cystic neoplasms diagnosed and treated are increasing over the past decade. Recent and long-tern risk and benefit should be well balanced when considering treatment, follow the principle of patient-benefit. For low malignancy potential neoplasm like serous cystic tumor or branch duct intraductal papillary mucinous neoplasm, surgical indication should be reserved to those with obvious malignant potential.Decreasing perioperative mortality and morbidity should be emphasized. Comprehensive studies are needed to validate the efficacy of new diagnostic and treatment technique before applied to clinical...
January 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29322510/lolium-perenne-peptide-immunotherapy-is-well-tolerated-and-elicits-a-protective-b-cell-response-in-seasonal-allergic-rhinitis-patients
#4
R Mösges, A F Koch, E Raskopf, J Singh, K Shah-Hosseini, B Hauswald, Y Yarin, F Corazza, L Haazen, S Pirotton, S Allekotte, G Zadoyan, T Legon, S R Durham, M H Shamji
BACKGROUND: Systemic allergic reactions are a risk for allergen immunotherapy that utilizes intact allergen preparations. We evaluated the safety, efficacy and immune mechanisms of short-course treatment with adjuvant-free Lolium perenne peptides (LPP) following a 6-week dose-escalation protocol. METHODS: In a prospective, dose-escalation study, 61 grass pollen-allergic patients received 2 subcutaneous injections of LPP once weekly for 6 weeks. Safety was assessed evaluating local reactions, systemic reactions and adverse events...
January 10, 2018: Allergy
https://www.readbyqxmd.com/read/29317155/compensatory-mechanism-of-the-spine-after-corrective-surgery-without-lumbar-sacral-fixation-for-traumatic-thoracolumbar-kyphotic-spine-deformity
#5
Koji Matsumoto, Masahiro Hoshino, Keita Omori, Hidetoshi Igarashi, Takashi Tsuruta, Koji Yamasaki, Hiromi Matsuzaki, Takanori Iriuchishima, Yasuaki Tokuhashi
BACKGROUND: It remains unclear whether long fusion including lumbar-sacral fixation is needed in corrective surgery to obtain good global sagittal balance (GSB) for the treatment of traumatic thoracolumbar kyphotic spine deformity. The purposes of this study were to evaluate compensatory mechanism of the spine after corrective surgery without lumbar-sacral fixation and to evaluate the parameters affecting the achievement of good GSB post-operatively. METHODS: Twenty (20) subjects requiring corrective surgery (distal end of fixation was L3) were included in this study...
January 6, 2018: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/29315472/early-prognostic-factors-in-septic-shock-cancer-patients-a-prospective-study-with-a-proteomic-approach
#6
D Mokart, C Saillard, C Zemmour, M Bisbal, A Sannini, L Chow-Chine, J-P Brun, M Faucher, J-M Boher, Y Toiron, C Chabannon, J-P Borg, A Gonçalves, L Camoin
BACKGROUND: Organ failures are the main prognostic factors in septic shock. The aim was to assess classical clinico-biological parameters evaluating organ dysfunctions at intensive care unit admission, combined with proteomics, on day-30 mortality in critically ill onco-hematology patients admitted to the intensive care unit for septic shock. METHODS: This was a prospective monocenter cohort study. Clinico-biological parameters were collected at admission. Plasma proteomics analyses were performed, including protein profiling using isobaric Tag for Relative and Absolute Quantification (iTRAQ) and subsequent validation by ELISA...
January 7, 2018: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/29314872/collegiate-football-players-ankle-range-of-motion-and-dynamic-balance-in-braced-and-self-adherent-taped-conditions
#7
Kristin Willeford, Justin M Stanek, Todd A McLoda
CONTEXT:   Ankle sprains are one of the most common injuries in the physically active population. Previous researchers have shown that supporting the ankle with taping or bracing is effective in preventing ankle sprains. However, no authors have compared the effects of self-adherent tape and lace-up ankle braces on ankle range of motion (ROM) and dynamic balance in collegiate football players. OBJECTIVE:   To examine the effectiveness of self-adherent tape and lace-up ankle braces in reducing ankle ROM and improving dynamic balance before and after a typical collegiate football practice...
January 9, 2018: Journal of Athletic Training
https://www.readbyqxmd.com/read/29314657/molecular-and-genetic-interactions-of-the-rna-degradation-machineries-in-firmicute-bacteria
#8
REVIEW
Peter Redder
Correct balance between bacterial RNA degradation and synthesis is essential for controlling expression level of all RNAs. The RNA polymerase, which performs the RNA synthesis, is highly conserved across the bacterial domain. However, this is surprisingly not the case for the RNA degradation machinery, which is composed of different subunits and performs different enzymatic reactions, depending on the organism. In Escherichia coli, the RNA decay is performed by the degradosome complex, which forms around the membrane-associated endoribonuclease RNase E, and is stable enough to be purified without falling apart...
January 5, 2018: Wiley Interdisciplinary Reviews. RNA
https://www.readbyqxmd.com/read/29314584/qsar-analysis-of-plant-derived-compounds-with-larvicidal-activity-against-zika-aedes-aegypti-diptera-culicidae-vector-using-freely-available-descriptors
#9
Laura M Saavedra, Gustavo P Romanelli, Pablo R Duchowicz
BACKGROUND: We develop a QSAR model for predicting the larvicidal activity of 60 plant-derived molecules against Aedes aegypti L. (Diptera: Culicidae), vector of several diseases such as, dengue, yellow fever, chikungunya and Zika virus. The balanced subsets method (BSM) based on k-means cluster analysis (k-MCA) is employed to split the data set. The replacement method (RM) variable subset selection technique coupled with multivariable linear regression (MLR) proves to be successful for exploring 18,326 molecular descriptors and fingerprints calculated with PaDEL, Mold2 and EPI Suite open-source software...
January 4, 2018: Pest Management Science
https://www.readbyqxmd.com/read/29290452/short-communication-effects-of-dietary-5-6-dimethylbenzimidazole-supplementation-on-vitamin-b12-supply-lactation-performance-and-energy-balance-in-dairy-cows-during-the-transition-period-and-early-lactation
#10
D M Wang, B X Zhang, J K Wang, H Y Liu, J X Liu
The current study was conducted to investigate the effects of 5,6-dimethylbenzimidazole (DMB) supplementation to the feed during the transition period and early lactation on the vitamin B12 supply, lactation performance, and energy balance in postpartum cows. Twenty-four prepartum Holstein dairy cows were divided into 12 blocks based on their parity and milk yield at the last lactation and were then randomly allocated to 1 of 2 treatments: a basal diet without DMB (control) or a treatment diet that contained 1...
December 28, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29288562/interactions-between-host-sex-and-age-of-exposure-modify-the-virulence-transmission-trade-off
#11
Stephen A Y Gipson, Matthew D Hall
The patterns of immunity conferred by host sex or age represent two sources of host heterogeneity that can potentially shape the evolutionary trajectory of disease. With each host sex or age encountered, a pathogen's optimal exploitative strategy may change, leading to considerable variation in expression of pathogen transmission and virulence. To date, these host characteristics have been studied in the context of host fitness alone, overlooking the effects of host sex and age on the fundamental virulence-transmission trade-off faced by pathogens...
December 29, 2017: Journal of Evolutionary Biology
https://www.readbyqxmd.com/read/29286684/three-dimensional-general-relativistic-magnetohydrodynamic-simulations-of-remnant-accretion-disks-from-neutron-star-mergers-outflows-and-r-process-nucleosynthesis
#12
Daniel M Siegel, Brian D Metzger
The merger of binary neutron stars, or of a neutron star and a stellar-mass black hole, can result in the formation of a massive rotating torus around a spinning black hole. In addition to providing collimating media for γ-ray burst jets, unbound outflows from these disks are an important source of mass ejection and rapid neutron capture (r-process) nucleosynthesis. We present the first three-dimensional general-relativistic magnetohydrodynamic (GRMHD) simulations of neutrino-cooled accretion disks in neutron star mergers, including a realistic equation of state valid at low densities and temperatures, self-consistent evolution of the electron fraction, and neutrino cooling through an approximate leakage scheme...
December 8, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29284432/mujeres-fuertes-y-corazones-saludables-adaptation-of-the-strongwomen-healthy-hearts-program-for-rural-latinas-using-an-intervention-mapping-approach
#13
Cynthia K Perry, Jean C McCalmont, Judy P Ward, Hannah-Dulya K Menelas, Christie Jackson, Jazmyne R De Witz, Emma Solanki, Rebecca A Seguin
OBJECTIVE: To describe our use of intervention mapping as a systematic method to adapt an evidence-based physical activity and nutrition program to reflect the needs of rural Latinas. METHODS: An intervention mapping process involving six steps guided the adaptation of an evidence based physical activity and nutrition program, using a community-based participatory research approach. We partnered with a community advisory board of rural Latinas throughout the adaptation process...
December 28, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29280461/comparative-outcomes-after-definitive-chemoradiotherapy-using-proton-beam-therapy-versus-intensity-modulated-radiation-therapy-for-esophageal-cancer-a-retrospective-single-institutional-analysis
#14
Mian Xi, Cai Xu, Zhongxing Liao, Joe Y Chang, Daniel R Gomez, Melenda Jeter, James D Cox, Ritsuko Komaki, Reza Mehran, Mariela A Blum, Wayne L Hofstetter, Dipen M Maru, Manoop S Bhutani, Jeffrey H Lee, Brian Weston, Jaffer A Ajani, Steven H Lin
PURPOSE: To compare clinical outcomes between proton beam therapy (PBT) and intensity modulated radiation therapy (IMRT) in patients with esophageal cancer (EC) treated with definitive chemoradiotherapy (CRT). METHODS AND MATERIALS: From 2007 through 2014, 343 EC patients who received definitive CRT with either PBT (n=132) or IMRT (n=211) were retrospectively analyzed. Survival, recurrence, and treatment toxicity were compared between groups. A Cox proportional hazards regression model was performed to test the association between patient/treatment variables and survival...
November 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29260234/evaluation-of-a-multidisciplinary-rehabilitation-programme-for-elderly-patients-with-hip-fracture-a-prospective-cohort-study
#15
Wing-Hoi Cheung, Wan-Yiu Shen, David Lok-Kwan Dai, Kin Bong Lee, Tracy Y Zhu, Ronald Man-Yeung Wong, Kwok-Sui Leung
OBJECTIVE: To investigate the effectiveness and cost of an 18-month multi-disciplinary Comprehensive Fragility Fracture Management Program (CFFMP) for fragility hip fracture patients. DESIGN: Prospective cohort study. PATIENTS: Elderly patients with hip fracture were recruited at their first postoperative follow-up in 2 district hospitals. The intervention group comprised patients from the hospital undergoing CFFMP, and the control group comprised patients from another hospital undergoing conventional care...
December 20, 2017: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29259127/activated-heterotrimeric-g-protein-%C3%AE-i-subunits-inhibit-rap-dependent-cell-adhesion-and-promote-cell-migration
#16
Jesi Y To, Alan V Smrcka
Our recent work uncovered novel roles for activated Gαi signaling in regulation of neutrophil polarity and adhesion. GαiGTP-dependent enhancement neutrophil polarization was dependent on inhibition of cAMP/PKA signaling, while reversal of Gβγ stimulated adhesion was cAMP/PKA-independent. To uncover the mechanism for Gαi regulation of adhesion, we analyzed the effects of constitutively active Gαi1(Q204L) expression on adhesion driven by constitutively active Rap1a(G12V) or its downstream effector Radil in neutrophil-like HL60 cells, or in HT-1080 fibrosarcoma cells...
December 19, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29258868/when-exercise-does-not-pay-counterproductive-effects-of-impending-exercise-on-energy-intake-among-restrained-eaters
#17
Aaron Y Sim, Li Ling Lee, Bobby K Cheon
Evidence suggests people may overestimate the effectiveness of future positive behaviour, leading to counterproductive behaviours in the present. Applied to weight-management, we hypothesize that inaccurate expectations about impending exercise may impede weight management by promoting overconsumption prior to exercise. This study aimed to determine how expectations about impending exercise and its potential ability to expend energy may influence i) energy intake before exercise and ii) overall energy balance (energy intake minus energy expended via exercise)...
December 16, 2017: Appetite
https://www.readbyqxmd.com/read/29242998/contrasting-liquid-imbibition-into-uncoated-versus-pigment-coated-paper-enables-a-description-of-imbibition-into-new-generation-surface-filled-paper
#18
Guodong Liu, Sijia Fu, Zhaoqing Lu, Meiyun Zhang, Cathy Ridgway, Patrick Gane
The transport of print fluids into paper is directly dependent on the imbibition characteristic of the paper including both the z-, x- and y-directions. As the measurement of free liquid imbibition into the paper thickness (z-direction) is difficult experimentally, due to the thin nature of paper, in this paper we resort to imbibition along the y-direction of paper to analyse and explore the possibility of understanding the mechanistic differences between wicking into uncoated unfilled paper versus that of controllable pigment-filled paper and paper coating...
December 18, 2017: European Physical Journal. E, Soft Matter
https://www.readbyqxmd.com/read/29239998/seasonal-changes-in-functional-fitness-and-neurocognitive-assessments-in-youth-ice-hockey-players
#19
Michelle Avery, Nick Wattie, Michael Holmes, Shilpa Dogra
Deficits in balance and strength combined with differing rates of sensory and motor neural development may increase risk of sports related injury in youth. This study evaluated changes in functional fitness and concussion status over the course of a competitive season in youth ice-hockey players, and examined the relationship between these variables and injury occurrence. Thirty-six participants (8.9 ± 1.1 years) completed pre and post-season assessments including anthropometric measurements, the Functional Movement Screen (FMS), Lower Quarter Y-Balance Test (YBT-LQ), and a computerized neurocognitive assessment (ImPACT)...
December 11, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29239030/neuromuscular-training-reduces-lower-limb-injuries-in-elite-female-basketball-players-a-cluster-randomized-controlled-trial
#20
Matteo Bonato, Roberto Benis, Antonio La Torre
The study was a two-armed, parallel group, cluster randomized controlled trial in which 15 teams (160 players) were assigned to either an experimental group (EG, 8 teams n=86), which warmed-up with bodyweight neuromuscular exercises, or a control group (CG, 7 teams, n=74) that performed standard tactical-technical exercises before training. All injuries during the 2015-2016 regular season were counted. Epidemiologic incidence proportion and incidence rate, were also calculated. Counter movement jump (CMJ) and composite Y-Excursion balance test (YBT) were used to assess lower limb strength, and postural control...
December 14, 2017: Scandinavian Journal of Medicine & Science in Sports
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