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https://www.readbyqxmd.com/read/29782261/-chronic-kidney-disease-as-basis-of-high-thrombotic-and-bleeding-risk-in-patients-with-atrial-fibrillation-place-of-oral-anticoagulants
#1
A G Obrezan, A Y Zemchenkov
Chronic kidney disease (CKD) aggravates course of practically all diseases by worsening outcomes and hindering adequate treatment. Specificities of renal excretion of various drugs, changes of parameters of their pharmacokinetics and pharmacodynamics, nephrotoxic effects of drugs, tactics of drug therapy in conditions of CKD, terminal stage of kidney failure and dialysis are in the focus of attention of internists. To a greatest degree difficulties of drug therapy in CKD and associated clinical states refer to the group of anticoagulants...
April 2018: Kardiologiia
https://www.readbyqxmd.com/read/29781063/anticoagulation-resumption-after-intracerebral-hemorrhage
#2
REVIEW
Yan-Guang Li, Gregory Y H Lip
PURPOSE OF REVIEW: Decision-making on resuming oral anticoagulant (OAC) after intracerebral hemorrhage (ICH) evokes significant debate among clinicians. Such patients have been excluded from randomized clinical trials. This review article provides a comprehensive summary of the evidence on anticoagulation resumption after ICH. RECENT FINDINGS: OAC resumption does not increase the risk of recurrent ICH and can also reduce the risk of all-cause mortality. OAC cessation exposes patients to a significantly higher risk of thromboembolism, which could be reduced by resumption...
May 21, 2018: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/29775703/ultrastructural-characterization-of-corticotropin-releasing-factor-and-neuropeptide-y-in-the-rat-locus-coeruleus-anatomical-evidence-for-putative-interactions
#3
Catherine C Theisen, Beverly A S Reyes, E L Sabban, Elisabeth J Van Bockstaele
As a neurochemical mediator of stress resilience, NPY has been shown to oppose excitatory effects of the pro-stress neuropeptide corticotropin-releasing factor (CRF). Previous studies have described the anatomical organization of NPY and CRF in the central nucleus of the amygdala, which sends CRF projections to the locus coeruleus (LC), activating LC norepinephrine release. However, the cellular substrates for interactions between NPY and CRF in the LC remain unknown. In this study, we investigated these anatomical substrates in the male rat LC, using immunocytochemistry, confocal microscopy, and immunoelectron microscopy to detect NPY and CRF, as well as CRF and Y1 or Y2 receptors (Y1R or Y2R)...
May 15, 2018: Neuroscience
https://www.readbyqxmd.com/read/29770459/identification-of-correlative-shifts-in-indices-of-brain-cholesterol-metabolism-in-the-c57bl6-mecp2-tm1-1bird-mouse-a-model-for-rett-syndrome
#4
Dieter Lütjohann, Adam M Lopez, Jen-Chieh Chuang, Anja Kerksiek, Stephen D Turley
Rett syndrome (RS) is a pervasive neurodevelopmental disorder resulting from loss-of-function mutations in the X-linked gene methyl-Cpg-binding protein 2 (MECP2). Using a well-defined model for RS, the C57BL6/Mecp2 tm1.1Bird mouse, we have previously found a moderate but persistently lower rate of cholesterol synthesis, measured in vivo, in the brains of Mecp2 -/y mice, starting from about the third week after birth. There was no genotypic difference in the total cholesterol concentration throughout the brain at any age...
May 17, 2018: Lipids
https://www.readbyqxmd.com/read/29768678/the-ideal-strategy-for-cervical-cancer-screening-in-japan-result-from-the-fukui-cervical-cancer-screening-study
#5
T Kurokawa, T Onuma, A Shinagawa, Y Chino, M Kobayashi, Y Yoshida
OBJECTIVE: The aims of the Fukui Cervical Cancer Screening (FCCS) study are to determine the frequency of women with high-risk HPV (hrHPV), whether HPV16 or HPV18 (HPV16/18), in the Japanese cancer screening population for the first time and to identify the best strategy for cervical cancer screening in Japan. METHODS: This study enrolled 7,584 women ≥25 years of age who were undergoing routine screening. All women underwent liquid-based cytology and cobas HPV tests...
May 16, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29767680/propensity-for-adverse-pregnancy-outcomes-in-african-american-women-may-be-explained-by-low-energy-expenditure-in-early-pregnancy
#6
Jasper Most, L Anne Gilmore, Abby D Altazan, Marshall St Amant, Robbie A Beyl, Eric Ravussin, Leanne M Redman
Background: African-American (AA) women have poorer pregnancy outcomes and studies in nonpregnant women suggest a different etiology of weight gain in AA compared with white women. We hypothesized that physiologic factors such as low energy expenditure and physical activity would be present in AA compared with white women in pregnancy. Objective: We aimed to identify physiologic risk factors for disordered energy balance in AA and white women early in pregnancy...
May 14, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29765176/impairments-of-postural-control-functional-performance-and-strength-in-morbidly-obese-patients-awaiting-bariatric-surgery-in-comparison-to-healthy-individuals
#7
Max Lennart Eckstein, Jimmy Bradley Lawrence, Christoph Otto, Peggy Kotsch, Janin Messerschmidt, Richard Michael Bracken, Othmar Moser
[Purpose] There is a lack of information evaluating specific markers of performance in patients awaiting bariatric surgery. We aimed to assess the postural control, functional performance, strength and endurance performance for morbidly obese patients awaiting bariatric surgery compared to lean controls. [Subjects and Methods] All parameters were assessed by modified Y-balance test, timed-up-and-go-test, maximum strength testing on resistance exercise equipment and cardio-pulmonary exercise testing on a cycle ergometer in 10 morbidly obese patients awaiting bariatric surgery and 10 age- and sex-matched lean controls...
May 2018: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29765005/heart-rate-recovery-physical-activity-level-and-functional-status-in-subjects-with-copd
#8
Andrea A Morita, Laís K O Silva, Gianna W Bisca, Joice M Oliveira, Nidia A Hernandes, Fabio Pitta, Karina C Furlanetto
BACKGROUND: A normal heart rate reflects the balance between the sympathetic and parasympathetic autonomic nervous system. When the difference between heart rate at the end of an exercise test and after 1 min of recovery, known as the 1-min heart rate recovery, is ≤ 12 beats/min, this may indicate an abnormal delay. We sought to compare physical activity patterns and subjects' functional status with COPD with or without delayed 1-min heart rate recovery after the 6-min walk test (6MWT)...
May 15, 2018: Respiratory Care
https://www.readbyqxmd.com/read/29764702/a-novel-neuromodulation-technique-for-the-rehabilitation-of-balance-and-gait-a-case-study
#9
L Eduardo Cofré Lizama, Andisheh Bastani, Maya G Panisset, Katharine Drummond, Fary Khan, Mary P Galea
Cranial-nerve non-invasive neuromodulation (CN-NINM) through the tongue has been proposed as an adjuvant intervention to improve efficacy of rehabilitation. However, CN-NINM effects have only been explored in multiple sclerosis and stroke populations. In this report we used CN-NINM during a 2-week (2 × 1.5 h sessions daily) physiotherapy program for the rehabilitation of a 57 y/o woman presenting with balance and gait impairments after a surgical resection of a fourth ventricular ependymoma. Clinical and instrumented balance and gait assessments showed improved performance in all tests and without adverse effects This study shows the beneficial effects and feasibility of combined physiotherapy and CN-NINM in this patient...
May 12, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29764032/-genes-polymorphism-of-bin1-and-apoe-in-patients-with-amnestic-mild-cognitive-impairment-from-enshi-tujia-area
#10
J Chen, Y Xia, C L Gao, R X Wang, Z N Lu
Objective: To investigate the polymorphism of BIN1 and ApoE genes in amnestic mild cognitive impairment (aMCI) patients in Tujia minority area of Enshi, Hubei. Methods: A total of 107 patients with aMCI (aMCI group) and 150 healthy people (healthy control group) during the same period were included between December 2016 and October 2017 in Affiliated Minda Hospital of Hubei University for Nationalities, who were all the Tujia nationality. Three single nucleotide polymorphic site of BIN1 gene rs744373, rs7561528, rs6733839, and two single nucleotide polymorphic site of ApoE gene rs429358, rs7412, and Genotyping and sub-genotyping of ApoE genes were tested using ligase detection reaction technique(LDR), and gene polymorphisms of BIN1 and ApoE were analyzed with Logistic regression analysis...
May 8, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29759800/-hypertensive-crisis-and-anticholinergic-toxidrome-secondary-to-accidental-consumption-of-datura-stramonium-in-two-children
#11
D D Batouche, N-F Benatta, K Tabeliouna, S Boudjahfa, Y Touhami, S Hakkoum
OBJECTIVE: To identify a hypertensive clinical form of atropine or anticholinergic toxidrome secondary to accidental consumption of Datura seeds. PATIENTS AND METHODS: We report two cases of Datura intoxication in two children who presented marked anticholinergic syndrome whose diagnosis was made by the anamnesis and the clinic. RESULT: Patient 1: A 5-year-old boy, returns home agitated with balance disorders. He was admitted to pediatric resuscitation unit...
May 11, 2018: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/29758909/water-resources-conservation-and-nitrogen-pollution-reduction-under-global-food-trade-and-agricultural-intensification
#12
Wenfeng Liu, Hong Yang, Yu Liu, Matti Kummu, Arjen Y Hoekstra, Junguo Liu, Rainer Schulin
Global food trade entails virtual flows of agricultural resources and pollution across countries. Here we performed a global-scale assessment of impacts of international food trade on blue water use, total water use, and nitrogen (N) inputs and on N losses in maize, rice, and wheat production. We simulated baseline conditions for the year 2000 and explored the impacts of an agricultural intensification scenario, in which low-input countries increase N and irrigation inputs to a greater extent than high-input countries...
August 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29755513/motor-imagery-during-action-observation-of-locomotor-tasks-improves-rehabilitation-outcome-in-older-adults-after-total-hip-arthroplasty
#13
Uros Marusic, Sidney Grosprêtre, Armin Paravlic, Simon Kovač, Rado Pišot, Wolfgang Taube
This study aimed at determining whether the combination of action observation and motor imagery (AO + MI) of locomotor tasks could positively affect rehabilitation outcome after hip replacement surgery. Of initially 405 screened participants, 21 were randomly split into intervention group ( N = 10; mean age = 64 y; AO + MI of locomotor tasks: 30 min/day in the hospital, then 3×/week in their homes for two months) and control group ( N = 11, mean age = 63 y, active controls). The functional outcomes (Timed Up and Go, TUG; Four Step Square Test, FSST; and single- and dual-task gait and postural control) were measured before (PRE) and 2 months after surgery (POST)...
2018: Neural Plasticity
https://www.readbyqxmd.com/read/29754386/nutritional-deficiencies-in-chinese-patients-undergoing-gastric-bypass-and-sleeve-gastrectomy-prevalence-and-predictors
#14
Bingsheng Guan, Jingge Yang, Yanya Chen, Wah Yang, Cunchuan Wang
BACKGROUND: Nutritional deficiencies have been reported in bariatric surgery patients with inconsistent results. However, scarce data exist for Chinese patients. We aimed to assess nutritional deficiencies in Chinese patients undergoing Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG), and to identify predictors of postoperative nutritional status. METHODS: A retrospective review of a prospectively collected database was conducted in the patients undergoing RYGB and SG in our hospital between June 2013 and January 2017...
May 12, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29753766/licorice-flavonoid-oil-enhances-muscle-mass-in-kk-a-y-mice
#15
Yasukiyo Yoshioka, Yoko Yamashita, Hideyuki Kishida, Kaku Nakagawa, Hitoshi Ashida
AIMS: Muscle mass is regulated by the balance between the synthesis and degradation of muscle proteins. Loss of skeletal muscle mass is associated with an increased risk of developing metabolic diseases such as obesity and type 2 diabetes mellitus. The aim of this study was to clarify the effects of licorice flavonoid oil on muscle mass in KK-Ay /Ta mice. MAIN METHODS: Male genetically type II diabetic KK-Ay /Ta mice received 0, 1, or 1.5 g/kg BW of licorice flavonoid oil by mouth once daily for 4 weeks...
May 10, 2018: Life Sciences
https://www.readbyqxmd.com/read/29751614/effects-of-dietary-acute-tryptophan-depletion-atd-on-npy-serum-levels-in-healthy-adult-humans-whilst-controlling-for-methionine-supply-a-pilot-study
#16
Janice W Y Wong, Hugo A E Morandini, Vita L S Dingerkus, Tilman J Gaber, Kevin C Runions, Pradeep Rao, Simone Mahfouda, Katrin Helmbold, Sarah Bubenzer-Busch, Rebecca Koenemann, Richard M Stewart, Florian D Zepf
Central nervous serotonin (5-HT) can influence behaviour and neuropsychiatric disorders. Evidence from animal models suggest that lowered levels of neuropeptide Y (NPY) may have similar effects, although it is currently unknown whether decreased central nervous 5-HT impact NPY concentrations. Given that the production of NPY is dependent on the essential amino acid methionine (MET), it is imperative to account for the presence of MET in such investigations. Hence, this study sought to examine the effects of acute tryptophan depletion (ATD; a dietary procedure that temporarily lowers central nervous 5-HT synthesis) on serum concentrations of NPY, whilst using the potential renal acid load indicator (PRAL) to control for levels of MET...
May 11, 2018: Nutrients
https://www.readbyqxmd.com/read/29751242/local-functional-connectivity-alterations-in-schizophrenia-bipolar-disorder-and-major-depressive-disorder
#17
Yange Wei, Miao Chang, Fay Y Womer, Qian Zhou, Zhiyang Yin, Shengnan Wei, Yifang Zhou, Xiaowei Jiang, Xudong Yao, Jia Duan, Ke Xu, Xi-Nian Zuo, Yanqing Tang, Fei Wang
BACKGROUND: Local functional connectivity (FC) indicates local or short-distance functional interactions and may serve as a neuroimaging marker to investigate the human brain connectome. Local FC alterations suggest a disrupted balance in the local functionality of the whole brain network and are increasingly implicated in schizophrenia (SZ), bipolar disorder (BD), and major depressive disorder (MDD). METHODS: We aim to examine the similarities and differences in the local FC across SZ, BD, and MDD...
April 10, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29748126/feeding-the-gut-after-revisional-bariatric-surgery-the-fate-of-126-enteral-access-tubes
#18
Andrew T Strong, Hana Fayazzadeh, Gautam Sharma, Kevin El-Hayek, Matthew Kroh, John Rodriguez
BACKGROUND: Revisional bariatric surgery (RBS) is associated with higher complication rates compared with primary bariatric surgery. Feeding tubes (FTs), including gastrostomy and jejunostomy tubes placed during RBS, may serve as a safety net to provide nutrition when oral intake is contraindicated or limited; however, FTs in this setting have not been well investigated. OBJECTIVES: This study aims to determine complications, use, and duration of FTs placed during RBS...
March 9, 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29746501/dietary-challenges-differentially-affect-activity-and-sleep-wake-behavior-in-mus-musculus-isolating-independent-associations-with-diet-energy-balance-and-body-weight
#19
Isaac J Perron, Brendan T Keenan, Karthikeyani Chellappa, Nicholas F Lahens, Nicole L Yohn, Keith R Shockley, Allan I Pack, Sigrid C Veasey
BACKGROUND AND AIMS: Associated with numerous metabolic and behavioral abnormalities, obesity is classified by metrics reliant on body weight (such as body mass index). However, overnutrition is the common cause of obesity, and may independently contribute to these obesity-related abnormalities. Here, we use dietary challenges to parse apart the relative influence of diet and/or energy balance from body weight on various metabolic and behavioral outcomes. MATERIALS AND METHODS: Seventy male mice (mus musculus) were subjected to the diet switch feeding paradigm, generating groups with various body weights and energetic imbalances...
2018: PloS One
https://www.readbyqxmd.com/read/29744935/fast-magnetic-resonance-fingerprinting-for-dynamic-contrast-enhanced-studies-in-mice
#20
Yuning Gu, Charlie Y Wang, Christian E Anderson, Yuchi Liu, He Hu, Mette L Johansen, Dan Ma, Yun Jiang, Ciro Ramos-Estebanez, Susann Brady-Kalnay, Mark A Griswold, Chris A Flask, Xin Yu
PURPOSE: The goal of this study was to develop a fast MR fingerprinting (MRF) method for simultaneous T1 and T2 mapping in DCE-MRI studies in mice. METHODS: The MRF sequences based on balanced SSFP and fast imaging with steady-state precession were implemented and evaluated on a 7T preclinical scanner. The readout used a zeroth-moment-compensated variable-density spiral trajectory that fully sampled the entire k-space and the inner 10 × 10 k-space with 48 and 4 interleaves, respectively...
May 9, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
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