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High cut off membrane

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https://www.readbyqxmd.com/read/29136724/-expert-consensus-for-the-diagnosis-and-treatment-of-patients-with-renal-impairment-of-multiple-myeloma
#1
(no author information available yet)
Renal impairment (RI) is a common complication of multiple myeloma (MM), which is presented as chronic kidney disease (CKD) or acute kidney injury (AKI). The typical pathological feature is cast nephropathy. Presently international system staging (ISS) is used in evaluating MM. Although the classic Durie-Salmon staging system could be still used in clinical practice, it may miss out some patients with renal impairment. For evaluations of RI in MM patients with CKD, it's recommended to assess the estimated glomerular filtration rate (eGFR) by creatinine based formula CKD-epidemiology collaboration (EPI) or modification of diet in renal disease(MDRD) and to stage the renal injuries according to 2013 Kidney Disease Improving Global Outcomes (KDIGO) CKD guidelines...
November 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29128957/expression-of-glut-1-in-malignant-melanoma-and-melanocytic-nevi-an-immunohistochemical-study-of-400-cases
#2
Miroslav Důra, Kristýna Němejcová, Radek Jakša, Michaela Bártů, Ondřej Kodet, Ivana Tichá, Romana Michálková, Pavel Dundr
The glucose transporter-1 (Glut-1) is a cell membrane glycoprotein involved in glucose uptake. An increased expression of Glut-1 is an important cell adaptation mechanism against hypoxia. An upregulation of Glut-1 can be found in several types of malignant tumors, which are able to reprogram their metabolism from oxidative phosphorylation to aerobic glycolysis (Warburg effect). However, the data regarding melanocytic lesions is equivocal. We performed comprehensive immunohistochemical analysis of the Glut-1 expression in 225 malignant melanomas (MM) and 175 benign nevi...
November 11, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/29108919/egfr-immunohistochemistry-as-biomarker-for-antibody-based-therapy-of-squamous-nsclc-experience-from-the-first-ring-trial-of-the-german-quality-assurance-initiative-for-pathology-quip-%C3%A2
#3
Iver Petersen, Manfred Dietel, Wolf J Geilenkeuser, Masoud Mireskandari, Wilko Weichert, Katja Steiger, Andreas H Scheel, Reinhard Büttner, Peter Schirmacher, Arne Warth, Felix Lasitschka, Hans-Ulrich Schildhaus, Thomas Kirchner, Simone Reu, Hans Kreipe, Florian Länger, Markus Tiemann, Christoph Schulte, Korinna Jöhrens
BACKGROUND: EGFR and its downstream signaling pathway are important targets for cancer therapy. Recently, the monoclonal anti-EGFR antibody Necitumumab in combination with gemcitabine and cisplatin was approved (EMA/14106/2016) for first-line treatment of squamous non-small cell carcinoma (SqNSCLC). Eligibility was restricted to cases with positive EGFR expression. In this context, a ring trial of the Quality Assurance Initiative for Pathology (QuIP(®)) was launched to prepare the German pathology community for a reliable and reproducible, immunohistochemically based biomarker test...
September 28, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29098820/-analyze-nanofiltration-separation-rule-of-chlorogenic-acid-from-low-concentration-ethanol-by-donnan-effect-and-solution-diffusion-effect
#4
Cun-Yu Li, Li-Cheng Liu, Li-Yang Jin, Hong-Yang Li, Guo-Ping Peng
To separate chlorogenic acid from low concentration ethanol and explore the influence of Donnan effect and solution-diffusion effect on the nanofiltration separation rule. The experiment showed that solution pH and ethanol volume percent had influences on the separation of chlorogenic acid. Within the pH values from 3 to 7 for chlorogenic acid in 30% ethanol, the rejection rate of chlorogenic acid was changed by 70.27%. Through the response surface method for quadratic regression model, an interaction had been found in molecule weight cut-off, pH and ethanol volume percent...
July 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29090523/digital-microscopy-as-a-screening-tool-for-the-diagnosis-of-hereditary-hemolytic-anemia
#5
R Huisjes, W W van Solinge, M D Levin, R van Wijk, J A Riedl
INTRODUCTION: Evaluation of red blood cell (RBC) morphology is an important first step in the differential diagnosis of hereditary hemolytic anemia. It is, however, labor intensive, expensive, and prone to subjectivity. To improve and standardize the analysis of RBC morphology as a screening tool in the diagnosis of hereditary hemolytic anemia, we studied its automated analysis by digital microscopy (DM). METHODS: Blood from 90 patients with hereditary hemolytic anemia and 32 normal control subjects was analyzed by the CellaVision DM96 Digital Microscope...
November 1, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29017155/effectiveness-of-ihd-with-adsorptive-pmma-membrane-in-myeloma-cast-nephropathy-a-cohort-study
#6
Florence Sens, Déborah Chaintreuil, Anne Jolivot, Fitsum Guebre-Egziabher, Philip Robinson, Lionel Karlin, Frank Bridoux, Laurent Juillard
BACKGROUND: In patients with cast nephropathy and acute kidney injury (AKI) requiring dialysis, the reduction of serum free light chains (FLC) using chemotherapy and intensive hemodialysis (IHD) with a high cut-off filter may improve renal and patient outcomes. We evaluated the effectiveness of a combination of chemotherapy and IHD with an adsorbent polymethylmethacrylate membrane (IHD-PMMA) on renal recovery and survival. METHODS: A single-center retrospective cohort-study was conducted...
October 10, 2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/28992849/severe-myoglobinuric-acute-kidney-injury-in%C3%A2-a%C3%A2-kidney-recipient-rapid-recovery-after-hemodialysis-with-the-super-high-flux-membrane-theralite%C3%A2-%C3%A2
#7
Ahmed Goubella, Fabrice Gankam-Kengne, Thomas Baudoux, David Fagnoul, Cécile Husson, Marie-Luce Delforge, Nilufer Broeders, Joëlle Nortier
Myoglobinuric acute kidney injury (AKI) is a severe condition requiring early therapeutic strategies. Early recognition and treatment are crucial to reduce morbidity and mortality rate. Here, we report a kidney recipient with severe rhabdomyolysis and AKI secondary to parvovirus B19 infection. Initiation of hemodialysis with the super high-flux filter Theralite® (Gambro, cut-off 45 kDa, 2.1 m2) resulted in the clearance of myoglobin from 61 to 71% after 3 hours. Elimination rates of IL-6 and β2-microglobulin were ~ 30 - 64% and 55 - 71% after 3 hours, respectively...
October 10, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/28992224/modulation-of-leucocytic-angiotensin-converting-enzymes-expression-in-patients-maintained-on-high-permeable-haemodialysis
#8
Bogusz Trojanowicz, Christof Ulrich, Roman Fiedler, Peter Martus, Markus Storr, Torsten Boehler, Kristin Werner, Michael Hulko, Daniel Zickler, Kevin Willy, Ralf Schindler, Matthias Girndt
Background: High mortality of haemodialysis patients is associated with systemic chronic inflammation and overactivation of the renin-angiotensin system (RAS). Insufficient elimination of pro-inflammatory immune mediators, especially in the molecular weight range of 15-45 kDa, may be one of the reasons for this. Employment of haemodialysis membranes with increased permeability was shown to ameliorate the inflammatory response and might modulate the effects of local RAS. In this study, we tested the impact of high cut-off (HCO), medium cut-off (MCO) and high-flux (HF) dialysis on leucocytic transcripts of angiotensin-converting enzymes (ACE and ACE2)...
July 19, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28980429/metabolic-characteristics-of-programmed-cell-death-ligand-1-expressing-lung-cancer-on-18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography
#9
Kazuki Takada, Gouji Toyokawa, Tatsuro Okamoto, Shingo Baba, Yuka Kozuma, Taichi Matsubara, Naoki Haratake, Takaki Akamine, Shinkichi Takamori, Masakazu Katsura, Fumihiro Shoji, Hiroshi Honda, Yoshinao Oda, Yoshihiko Maehara
Programmed cell death-1 (PD-1) and programmed cell death-ligand 1 (PD-L1) have been identified as novel targets of immunotherapy of lung cancer. In present study, we evaluated the metabolic characteristics of lung cancer by using (18) F-fluorodeoxyglucose positron emission tomography/computed tomography ((18) F-FDG PET/CT) with regard to PD-L1 protein expression. PD-L1 protein expression was evaluated by immunohistochemistry with the antibody clone SP142 in 579 surgically resected primary lung cancer patients...
November 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28963830/-uremic-toxins-how-can-we-improve-the-removal-today
#10
REVIEW
Ugo Teatini, Giorgio Romei Longhena
Uremic status results from a malfunctioning of kidneys due to the accumulation of compounds which, under normal conditions, are excreted or metabolized by the kidneys. If these compounds are biologically active, they are called uremic toxins. Such compounds have toxic effects on the cardio-vascular system. An useful classification, published by the European Uremic Toxin Work Group (EUTox) is: 1) small water-soluble compounds; 2) protein-bound compounds; 3) the larger "middle molecules". High-flux membranes and more efficient treatment techniques, like HDF, improve the removal of uremic toxins in the middle molecular-weight range, and recent studies suggest that these strategies have better results on the morbidity and mortality...
September 28, 2017: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/28935926/ultrasensitive-quantitation-of-anti-phospholipase-a2-receptor-antibody-as-a-diagnostic-and-prognostic-indicator-of-idiopathic-membranous-nephropathy
#11
Qiuhua Zhang, Biao Huang, Xiaobin Liu, Bin Liu, Yi Zhang, Zhijian Zhang, Jia Hua, Yun Fan, Ling Hu, Meijuan Meng, Mian Wu, Liang Wang, Zhigang Hu, Zhuxing Sun
Anti-phospholipase A2 receptor antibody (PLA2R-Ab) is useful for affirming the diagnosis of idiopathic membranous nephropathy (IMN). Time-resolved fluoroimmunoassay (TRFIA) is highly sensitive and quantitative for measuring serum PLA2R-Ab immunoglobulin (IgG). We measured PLA2R-Ab levels with TRFIA in sera from 172 patients with IMN (n = 69), secondary MN (n = 9), and those with other glomerulonephritis (n = 94) at the time of renal biopsy compared to healthy controls (n = 286). Serum anti-PLA2R-IgG levels in healthy volunteers ranged from 0...
September 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28910800/the-place-of-large-pore-membranes-in-the-treatment-portfolio-of-patients-on-hemodialysis
#12
Wim Van Biesen, Raymond Vanholder, Eva Schepers, Griet Glorieux, Annemieke Dhondt, Sunny Eloot
Cardiovascular disease is a major concern in patients with end-stage kidney disease (ESKD). Inflammation induced by retention of uremic toxins, of which a substantial fraction has a molecular weight in the middle molecular range, has been associated with increased cardiovascular risk. In an attempt to reduce inflammation and thus cardiovascular toxicity in patients with ESKD, hemodiafiltration (HDF) has been promoted to enhance the clearance of middle molecular weight substances during dialysis. However, HDF increases the technical complexity and costs, and requires ultrapure dialysis fluid...
2017: Contributions to Nephrology
https://www.readbyqxmd.com/read/28910799/effects-of-hemodialysis-therapy-using-dialyzers-with-medium-cut-off-membranes-on-middle-molecules
#13
Alexander H Kirsch, Alexander R Rosenkranz, Raphael Lyko, Detlef H Krieter
The removal of larger middle molecules, such as free immunoglobulin light chains (FLC), is poor with most currently used dialysis technologies. While hemodiafiltration (HDF) provides enhanced clearance of middle molecules compared to high-flux hemodialysis (HD), this technique is currently not approved in some regions and, hence, not accessible for all patients. The retention of middle molecules is thought to be one factor, which contributes to excessive morbidity and mortality in HD patients. The development of medium cut-off (MCO) dialysis membranes is aimed at a more efficient clearance of larger uremic toxins while retaining albumin and may extend the benefit of enhanced solute removal to more patients...
2017: Contributions to Nephrology
https://www.readbyqxmd.com/read/28910795/multidimensional-classification-of-dialysis-membranes
#14
Claudio Ronco, Mauro Neri, Anna Lorenzin, Francesco Garzotto, William R Clark
Hemodialysis is a process of mass separation by a semipermeable membrane, utilized to cleanse blood from waste products retained in case of kidney failure. Traditionally, dialysis membranes have been classified based on composition and hydraulic conductance, creating the net differentiation between cellulosic versus non-cellulosic on one hand and low-flux versus high-flux on the other. With the evolution of biomaterials and improved spinning technology, new membranes have been introduced in the market with specific characteristics and refined individual properties...
2017: Contributions to Nephrology
https://www.readbyqxmd.com/read/28910786/the-evolving-patterns-of-uremia-unmet-clinical-needs-in-dialysis
#15
Xueqing Yu
End-stage renal disease (ESRD) has become a challenging health problem worldwide. Currently, ESRD patients treated with hemodialysis mainly undergo low-flux hemodialysis, high-flux hemodialysis (HF-HD), or hemodiafiltration (HDF). The clearance of middle and large molecules is, however, quite insufficient as regards HF-HD, HDF, and on-line HDF. An unsatisfactory prognosis has led to improved dialysis technology and materials; both protein-leaking membranes and high cut-off membranes increase the clearance of uremic toxin, but in clinical application they may induce albumin loss...
2017: Contributions to Nephrology
https://www.readbyqxmd.com/read/28894043/immune-disorders-in-sepsis-and-their-treatment-as-a-significant-problem-of-modern-intensive-care
#16
Lidia Łysenko, Patrycja Leśnik, Kamil Nelke, Hanna Gerber
Despite the great advances in the treatment of sepsis over the past 20 years, sepsis remains the main cause of death in intensive care units. In the context of new possibilities of treating sepsis, a comprehensive response of the immune system to the infection, immunosuppression, in particular, has in recent years gained considerable interest. There is vast evidence pointing to the correlation between comorbid immunosuppression and an increased risk of recurrent infections and death. Immune disorders may impact the clinical course of sepsis...
August 22, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/28862721/in-vitro-benchmark-of-cytokine-removal-by-dialyzers-with-various-permeability-profiles
#17
Michael Hulko, Rose Speidel, Julia Gauss, Markus Storr, Bernd Krause
PURPOSE: Removal of cytokines is relevant for dialysis patients as they are suspected to promote cardiovascular complications. The objective of this study was to benchmark membranes with different permeability profiles under standardized in vitro test conditions using miniaturized devices with respect to their ability to remove cytokines from human serum and to lower cell activating potential. METHODS: In vitro dialysis was used to dialyze cytokine enriched serum in 3 independent experiments per tested membrane...
August 11, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28852136/high-predictive-values-of-rbc-membrane-based-diagnostics-by-biophotonics-in-an-integrated-approach-for-autism-spectrum-disorders
#18
Giorgia Giacometti, Carla Ferreri, Anna Sansone, Chryssostomos Chatgilialoglu, Carla Marzetti, Ellas Spyratou, Alexandros G Georgakilas, Marina Marini, Provvidenza M Abruzzo, Alessandra Bolotta, Alessandro Ghezzo, Renato Minguzzi, Annio Posar, Paola Visconti
Membranes attract attention in medicine, concerning lipidome composition and fatty acid correlation with neurological diseases. Hyperspectral dark field microscopy (HDFM), a biophotonic imaging using reflectance spectra, provides accurate characterization of healthy adult RBC identifying a library of 8 spectral end-members. Here we report hyperspectral RBC imaging in children affected by Autism Spectrum Disorder (ASD) (n = 21) compared to healthy age-matched subjects (n = 20), investigating if statistically significant differences in their HDFM spectra exist, that can comprehensively map a membrane impairment involved in disease...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28778109/reference-ranges-for-ultrasonographic-measurements-of-the-uterine-cervix-in-low-risk-pregnant-women
#19
Kleber Cursino Andrade, Thaísa Guedes Bortoletto, Cristiane Martins Almeida, Renan Antonio Daniel, Heloísa Avo, Rodolfo Carvalho Pacagnella, José Guilherme Cecatti
Objective To define transvaginal ultrasound reference ranges for uterine cervix measurements according to gestational age (GA) in low-risk pregnancies. Methods Cohort of low-risk pregnant women undergoing transvaginal ultrasound exams every 4 weeks, comprising measurements of the cervical length and volume, the transverse and anteroposterior diameters of the cervix, and distance from the entrance of the uterine artery into the cervix until the internal os. The inter- and intraobserver variabilities were assessed with the linear correlation coefficient and the Student t-test...
September 2017: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/28777138/high-serum-bilirubin-levels-nt-pro-bnp-and-lactate-predict-mortality-in-long-term-severely-ill-respiratory-extracorporeal-membrane-oxygenation-patients
#20
Franziska Kaestner, Daniel Rapp, Franziska C Trudzinski, Nicole Olewczynska, Stefan Wagenpfeil, Frank Langer, Monika Flaig, Heinrike Wilkens, Robert Bals, Matthias Klingele, Christian Lensch, Sebastian Fähndrich, Philipp M Lepper
Mortality in patients treated with extracorporeal membrane oxygenation (ECMO) is high. Therefore, it is crucial to better understand conditions that are associated with mortality in ECMO patients. In this retrospective analysis, we observed 51 patients treated with high-flow ECMO in 2013 and 2014 at our center. We recorded laboratory values and intensive care procedures. The hypothesis of bilirubin being a predictor of mortality during ECMO treatment was initially addressed. Therefore, laboratory values were obtained before initiation and at the time of highest bilirubin throughout the procedure...
August 2, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
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