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High cut off membrane

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https://www.readbyqxmd.com/read/28073845/agreement-between-programmed-cell-death-ligand-1-diagnostic-assays-across-multiple-protein-expression-cut-offs-in-non-small-cell-lung-cancer
#1
Marianne J Ratcliffe, Alan Sharpe, Anita Midha, Craig Barker, Marietta Scott, Paul Scorer, Hytham Al-Masri, Marlon Rebelatto, Jill Walker
PURPOSE: agents:Immunotherapies targeting programmed cell death-1 (PD-1) and programmed cell death ligand-1 (PD-L1) demonstrate encouraging antitumor activity and manageable tolerability in non-small cell lung cancer (NSCLC), especially in patients with high tumor PD-L1 expression, as detected by companion or complementary diagnostic assays developed for individual agents. A laboratory is unlikely to use multiple assay platforms. Furthermore, commercially available diagnostic assays are not standardized and different assay methods could lead to inappropriate treatment selection...
January 10, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28042837/purification-and-characterization-of-antioxidant-peptides-of-pseudosciaena-crocea-protein-hydrolysates
#2
Ningning Zhang, Chong Zhang, Yuanyuan Chen, Baodong Zheng
Two peptides with antioxidant activity were isolated from Pseudosciaena crocea proteins. Pseudosciaena crocea muscle was hydrolyzed with neutral protease to obtain Pseudosciaena crocea protein hydrolysates (PCPH). After ultrafiltration through molecular weight cut-off membranes of 10, 5 and 3 kDa and assessment of free radical scavenging ability, the fraction (PCPH-IV) with the highest antioxidant activity was obtained. Several purification steps, i.e., ion exchange chromatography, gel filtration chromatography and reversed phase high performance liquid chromatography, were applied to further purify PCPH-IV...
December 30, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27987984/biological-and-structural-analyses-of-bovine-heparin-fractions-of-intermediate-and-high-molecular-weight
#3
Alexsandro V Nogueira, Daiana L Drehmer, Marcello Iacomini, Guilherme L Sassaki, Thales R Cipriani
Low molecular weight heparin, which is generally obtained by chemical and enzymatic depolymerization of unfractionated heparin, has high bioavailability and can be subcutaneously injected. The aim of the present investigation was to fractionate bovine heparin using a physical method (ultrafiltration through a 10kDa cut-off membrane), avoiding structural modifications that can be caused by chemical or enzymatic treatments. Two fractions with different molecular weights were obtained: the first had an intermediate molecular weight (B-IMWH; Mn=9587Da) and the other had a high molecular weight (B-HMWH; 22,396Da)...
February 10, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27888732/biorefinery-of-microalgal-soluble-proteins-by-sequential-processing-and-membrane-filtration
#4
C Safi, G Olivieri, R P Campos, N Engelen-Smit, W J Mulder, L A M van den Broek, L Sijtsma
A mild biorefinery process was investigated on the microalga Nannochloropsis gaditana, to obtain an enriched fraction of water soluble proteins free from chlorophyll. After harvesting, a 100g.L(-1) solution of cells was first subjected to cell disruption by either high-pressure homogenization (HPH) or enzymatic treatment (ENZ). HPH resulted in a larger release of proteins (49%) in the aqueous phase compared to the Alcalase incubation (35%). In both cases, an ultrafiltration/diafiltration (UF/DF) was then performed on the supernatant obtained from cell disruption by testing different membrane cut-off (1000kDa, 500kDa and 300kDa)...
February 2017: Bioresource Technology
https://www.readbyqxmd.com/read/27887601/protocol-for-a-prospective-randomized-study-on-neurophysiological-assessment-of-lower-urinary-tract-function-in-a-healthy-cohort
#5
Stéphanie van der Lely, Martina Stefanovic, Melanie R Schmidhalter, Marta Pittavino, Reinhard Furrer, Martina D Liechti, Martin Schubert, Thomas M Kessler, Ulrich Mehnert
BACKGROUND: Lower urinary tract symptoms are highly prevalent and a large proportion of these symptoms are known to be associated with a dysfunction of the afferent pathways. Diagnostic tools for an objective and reproducible assessment of afferent nerve function of the lower urinary tract are missing. Previous studies showed first feasibility results of sensory evoked potential recordings following electrical stimulation of the lower urinary tract in healthy subjects and patients. Nevertheless, a refinement of the methodology is necessary...
November 25, 2016: BMC Urology
https://www.readbyqxmd.com/read/27863531/effects-of-continuous-renal-replacement-therapy-on-linezolid-pharmacokinetic-pharmacodynamics-a-systematic-review
#6
Gianluca Villa, Paola Di Maggio, A Raffaele De Gaudio, Andrea Novelli, Riccardo Antoniotti, Enrico Fiaccadori, Chiara Adembri
BACKGROUND: Major alterations in linezolid pharmacokinetic/pharmacodynamic (PK/PD) parameters might be expected in critically ill septic patients with acute kidney injury (AKI) who are undergoing continuous renal replacement therapy (CRRT). The present review is aimed at describing extracorporeal removal of linezolid and the main PK-PD parameter changes observed in critically ill septic patients with AKI, who are on CRRT. METHOD: Citations published on PubMed up to January 2016 were systematically reviewed according to the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement...
November 19, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27812452/efficacy-of-indirect-elisa-for-serodiagnosis-of-melioidosis-using-immunodominant-antigens-from-non-pathogenic-burkholderia-thailandensis
#7
Sumet Wajanarogana, Kanyanan Kritsiriwuthinan
Melioidosis caused by gram negative bacteria, B. pseudomallei, is a fatal disease in the tropical and sub-tropical regions. However, sporadic cases have been reported in elsewhere. Early detection is imperative to reduce the mortality rate. Serological tests have being substantially developed using recombinant proteins as specific targeted antigens to melioidosis antibodies. In the present study, we focus on a truncated flagellin fragment (FLAG300) and outer membrane protein A (OmpABT) of B. thailandensis E264 as potential antigens for developing indirect ELISA to improve the serodiagnosis of melioidosis...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27775143/nickel-hydroxide-nanosheet-membranes-with-fast-water-and-organics-transport-for-molecular-separation
#8
Yan Qu, Qiu Gen Zhang, Faizal Soyekwo, Run Sheng Gao, Rui Xue Lv, Chen Xiao Lin, Meng Meng Chen, Ai Mei Zhu, Qing Lin Liu
Two-dimensional nanosheets of late show great promise as novel materials for size-selective separation membranes of high efficiency. Herein, we demonstrate a novel laminated nanofiltration membrane for fast water purification and organic solvent nanofiltration using the 1 nm-thick and 50 nm-wide nickel hydroxide nanosheets that are facilely prepared by a green chemistry method. The resulting membranes exhibit uniform and flectional two-dimensional laminated structure. With about 1 nm high laminated channels, they allow super-fast transport of water and organic solvents...
October 24, 2016: Nanoscale
https://www.readbyqxmd.com/read/27774905/estradiol-uptake-in-a-combined-magnetic-ion-exchange-ultrafiltration-miex-uf-process-during-water-treatment
#9
Alessandra Imbrogno, Jennifer Biscarat, Andrea Iris Schäfer
BACKGROUND: Estrogens and their synthetic analogues are widely used as pharmaceuticals. Upon oral administration these drugs are eventually excreted via urine. The persistence of these pharmaceuticals and inefficient removal by water treatment lead to accumulation in surface water and effluents with negative effects for aquatic life and human health. METHODS: In this study, the uptake of estradiol by a combined magnetic ion exchange resin - ultrafiltration process (MIEX-UF) was investigated...
October 21, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27717372/development-of-a-programmed-cell-death-ligand-1-immunohistochemical-assay-validated-for-analysis-of-non-small-cell-lung-cancer-and-head-and-neck-squamous-cell-carcinoma
#10
Marlon C Rebelatto, Anita Midha, Amita Mistry, Constantine Sabalos, Nicole Schechter, Xia Li, Xiaoping Jin, Keith E Steele, Paul B Robbins, John A Blake-Haskins, Jill Walker
BACKGROUND: A high-quality programmed cell-death ligand 1 (PD-L1) diagnostic assay may help predict which patients are more likely to respond to anti-programmed cell death-1 (PD-1)/PD-L1 antibody-based cancer therapy. Here we describe a PD-L1 immunohistochemical (IHC) staining protocol developed by Ventana Medical Systems Inc. and key analytical parameters of its use in formalin-fixed, paraffin-embedded (FFPE) samples of non-small cell lung cancer (NSCLC) and head and neck squamous cell carcinoma (HNSCC)...
October 8, 2016: Diagnostic Pathology
https://www.readbyqxmd.com/read/27703642/immunohistochemistry-study-of-p53-and-c-erbb-2-expression-in-trophoblastic-tissue-and-their-predictive-values-in-diagnosing-malignant-progression-of-simple-molar-pregnancy
#11
Malihe Hasanzadeh, Norrie Sharifi, Marjaneh Farazestanian, Seyed Saman Nazemian, Faezeh Madani Sani
BACKGROUND: Finding a tumor marker to predict the aggressive behavior of molar pregnancy in early stages has yet been a topic for studies. OBJECTIVES: In this survey we planned to study patients with molar pregnancy to 1) assess the p53 and c-erbB-2 expression in trophoblastic tissue, 2) to study the relationship between their expression intensity and progression of a molar pregnancy to gestational trophoblastic neoplasia, and 3) to determine a cut off value for the amount of p53 and c-erbB-2 expression which might correlate with aggressive behavior of molar pregnancy...
June 2016: Iranian Journal of Cancer Prevention
https://www.readbyqxmd.com/read/27670395/impact-of-serum-and-dialysates-obtained-from-chronic-hemodialysis-patients-maintained-on-high-cut-off-membranes-on-inflammation-profile-in-human-thp-1-monocytes
#12
Bogusz Trojanowicz, Christof Ulrich, Roman Fiedler, Markus Storr, Torsten Boehler, Peter Martus, Michael Pawlak, Marcus A Glomb, Christian Henning, Markus Templin, Kristin Werner, Daniel Zickler, Kevin Willy, Ralf Schindler, Matthias Girndt
Introduction Patients with chronic kidney disease maintained on intermittent hemodialysis suffer from systemic chronic inflammation which is causally associated with high mortality. Inflammation mediators of 15-45 kDa range cannot be effectively removed by conventional dialysis membranes. In this study, we tested the influence of serum and dialysates obtained from patients maintained on High cut-off or High flux membranes on the inflammation profile of THP-1 monocytes. Methods THP-1 monocytes were treated with serum or dialysates obtained from patients maintained on High cut-off and High flux membranes within a randomized crossover pilot trial...
September 26, 2016: Hemodialysis International
https://www.readbyqxmd.com/read/27663975/prevention-of-adhesions-in-the-temporomandibular-joint-by-the-use-of-chitosan-membrane-in-goats
#13
Hp Li, Sf Sun, Bt Fan, P Shen, Js Zheng, Sy Zhang
We evaluated the effects of chitosan membrane, a highly absorbable and viscous material, in the prevention of intra-articular adhesions after anchoring of the disc in the temporomandibular joints (TMJ) of six adult goats (12 joints). To simulate anterior displacement of the disc and TMJ trauma, we cut off the retrodiscal attachment and damaged the surface of the condylar bone, then randomly divided the goats into two groups: the control group (n=2) and the experimental group (n=4). In the experimental group we covered the condylar surfaces on both sides of the animals with chitosan membranes...
September 20, 2016: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/27646819/current-treatments-for-renal-failure-due-to-multiple-myeloma
#14
Maria Gavriatopoulou, Evangelos Terpos, Efstathios Kastritis, Meletios A Dimopoulos
Renal impairment (RI) is one of the most common complication of multiple myeloma (MM). RI is present in almost 20% of MM patients at diagnosis and in 40%-50% of patients during the course of their disease. Areas covered: Biology along with tools for diagnosis and management of RI are reported in this paper. Papers published in PubMed and reported abstracts up to May 2016 were used. Expert opinion: Moderate and severe RI increases the risk of early death; thus rapid intervention and initiation of anti-myeloma treatment is essential and improves renal outcomes in RI patients...
November 2016: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/27627366/robust-ion-current-oscillations-under-a-steady-electric-field-an-ion-channel-analog
#15
Yu Yan, Yunshan Wang, Satyajyoti Senapati, Jarrod Schiffbauer, Gilad Yossifon, Hsueh-Chia Chang
We demonstrate a nonlinear, nonequilibrium field-driven ion flux phenomenon, which unlike Teorell's nonlinear multiple field theory, requires only the application of one field: robust autonomous current-mass flux oscillations across a porous monolith coupled to a capillary with a long air bubble, which mimics a hydrophobic protein in an ion channel. The oscillations are driven by the hysteretic wetting dynamics of the meniscus when electro-osmotic flow and pressure driven backflow, due to bubble expansion, compete to approach zero mass flux within the monolith...
August 2016: Physical Review. E
https://www.readbyqxmd.com/read/27587605/performance-of-hemodialysis-with-novel-medium-cut-off-dialyzers
#16
Alexander H Kirsch, Raphael Lyko, Lars-Göran Nilsson, Werner Beck, Michael Amdahl, Petra Lechner, Andreas Schneider, Christoph Wanner, Alexander R Rosenkranz, Detlef H Krieter
BACKGROUND: Compared to high-flux dialysis membranes, novel medium cut-off (MCO) membranes show greater permeability for larger middle molecules. METHODS: In two prospective, open-label, controlled, randomized, crossover pilot studies, 39 prevalent hemodialysis (HD) patients were studied in four dialysis treatments as follows: study 1, three MCO prototype dialyzers (AA, BB and CC with increasing permeability) and one high-flux dialyzer in HD; and study 2, two MCO prototype dialyzers (AA and BB) in HD and high-flux dialyzers in HD and hemodiafiltration (HDF)...
September 1, 2016: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/27577325/extracorporeal-lung-support-and-continuous-renal-replacement-therapy-in-series-combination-the-role-of-high-cut-off-membranes
#17
Guglielmo Consales, Lucia Zamidei, Giuliano Michelagnoli
No abstract text is available yet for this article.
2016: Blood Purification
https://www.readbyqxmd.com/read/27542480/betalain-rich-functional-extract-with-reduced-salts-and-nitrate-content-from-red-beetroot-beta-vulgaris-l-using-membrane-separation-technology
#18
Ram Mereddy, Adeline Chan, Kent Fanning, Nilesh Nirmal, Yasmina Sultanbawa
An initial laboratory-scale evaluation of separation characteristics of membranes with nominal molecular weight cut-offs (NMWCO) ranging from 30kD down to 0.5kD indicated effective separation of betalains in the 0.5kD region. Subsequent pilot-level trials using 1kD, loose reverse osmosis (LRO) and reverse osmosis (RO) spiral-wound membranes showed LRO membrane to be very efficient with up to 96% salt and 47% other dissolved solids removed while retaining majority of the pigment (∼98%) in the betalain rich extract (BRE)...
January 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27532547/a-robust-and-efficient-production-and-purification-procedure-of-recombinant-alzheimers-disease-methionine-modified-amyloid-%C3%AE-peptides
#19
Marie Hoarau, Yannick Malbert, Romain Irague, Christelle Hureau, Peter Faller, Emmanuel Gras, Isabelle André, Magali Remaud-Siméon
An improved production and purification method for Alzheimer's disease related methionine-modified amyloid-β 1-40 and 1-42 peptides is proposed, taking advantage of the formation of inclusion body in Escherichia coli. A Thioflavin-S assay was set-up to evaluate inclusion body formation during growth and optimize culture conditions for amyloid-β peptides production. A simple and fast purification protocol including first the isolation of the inclusion bodies and second, two cycles of high pH denaturation/ neutralization combined with an ultrafiltration step on 30-kDa cut-off membrane was established...
2016: PloS One
https://www.readbyqxmd.com/read/27467401/therapeutic-efficacy-and-cost-effectiveness-of-high-cut-off-dialyzers-compared-to-conventional-dialysis-in-patients-with-cast-nephropathy
#20
Adriano Curti, Albin Schwarz, Johannes Trachsler, Yuki Tomonaga, Patrice M Ambühl
BACKGROUND: High Cut-Off (HCO) dialysis membranes efficiently reduce serum free light chain (FLC) concentrations and may improve renal recovery and survival from multiple myeloma (MM) associated renal failure with cast nephropathy. However, clinical trials comparing dialysis with HCO versus conventional filters are lacking. The aim of this study was to assess clinical outcomes and economic impact of HCO dialyzers compared to conventional hemodialysis membranes in cast nephropathy. METHODS: Multicenter retrospective analysis of 19 patients treated for renal failure from FLC associated cast nephropathy with standard induction chemotherapy (bortezomib/dexamethasone)...
2016: PloS One
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