keyword
MENU ▼
Read by QxMD icon Read
search

menagment

keyword
https://www.readbyqxmd.com/read/28528777/fcab-her2-interaction-a-m%C3%A3-nage-%C3%A3-trois-lessons-from-x-ray-and-solution-studies
#1
Elisabeth Lobner, Anne-Sophie Humm, Kathrin Göritzer, Georg Mlynek, Martin G Puchinger, Christoph Hasenhindl, Florian Rüker, Michael W Traxlmayr, Kristina Djinović-Carugo, Christian Obinger
The crystallizable fragment (Fc) of the immunoglobulin class G (IgG) is an attractive scaffold for the design of novel therapeutics. Upon engineering the C-terminal loops in the CH3 domains, Fcabs (Fc domain with antigen-binding sites) can be designed. We present the first crystal structures of Fcabs, i.e., of the HER2-binding clone H10-03-6 having the AB and EF loop engineered and the stabilized version STAB19 derived by directed evolution. Comparison with the crystal structure of the Fc wild-type protein reveals conservation of the overall domain structures but significant differences in EF-loop conformations...
May 18, 2017: Structure
https://www.readbyqxmd.com/read/28516118/quantitative-measurements-of-hiv-1-and-dextran-capture-by-human-monocyte-derived-dendritic-cells-mddcs
#2
Mickaël M Ménager, Dan R Littman
The aim of this protocol is to describe how to measure and quantify the amount of HIV-1 particles and dextran molecules internalized in human monocyte derived dendritic cells (MDDCs), using three different techniques: flow cytometry, quantitative PCR and confocal microscopy. BACKGROUND: This protocol was developed in order to assess the changes of HIV-1 internalization upon disruption of actin nucleation in human monocyte derived dendritic cells. Following a shRNA screen to identify genes important for HIV-1 transfer from dendritic cells to T cells, we observed that a disruption of actin nucleation leads to a switch from actin rich dendrites to blebs, due to an excess of actomyosin contraction...
November 20, 2016: Bio-protocol
https://www.readbyqxmd.com/read/28495647/prevalence-of-human-cosavirus-and-saffold-virus-with-an-emergence-of-saffold-virus-genotype-6-in-patients-hospitalized-with-acute-gastroenteritis-in-chiang-mai-thailand-2014-2016
#3
Lucy Menage, Arpaporn Yodmeeklin, Pattara Khamrin, Kattareeya Kumthip, Niwat Maneekarn
Human cosavirus and saffold virus are both newly discovered members of the Picornaviridae family. It has been suggested that these viruses may be the causative agents of acute gastroenteritis. In this study, 1093 stool samples collected from patients with acute gastroenteritis between January 2014 and December 2016, were screened for cosavirus and saffold virus using reverse transcription-polymerase chain reaction. The viral genotypes were then established via nucleotide sequencing. Here, cosavirus was detected in 16 of 1093 stool samples (1...
May 8, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28491005/puritan-s-view-of-the-m%C3%A3-nage-%C3%A3-trois
#4
COMMENT
Libor Velisek
No abstract text is available yet for this article.
March 2017: Epilepsy Currents
https://www.readbyqxmd.com/read/28486146/plant-insect-pathogen-interactions-a-naturally-complex-m%C3%A3-nage-%C3%A3-trois
#5
REVIEW
Flávia P Franco, Daniel S Moura, Jorge M Vivanco, Marcio C Silva-Filho
Under environmental conditions, plants are constantly exposed to a wide range of biotic interactions, which include insects, and pathogens. Usually scientists are tempted to study each association individually, which reduces the complexity of the interaction. This restricted view of the problem does not consider that plants are the ballroom in which a multitude of organisms are constantly interacting with each other affecting not only plant responses but also how one organism responds to the other. Plants attacked by insects and pathogens display profound physiological, morphological and chemical changes or adaptations that result in organism attraction or avoidance, depending on the species involved...
May 6, 2017: Current Opinion in Microbiology
https://www.readbyqxmd.com/read/28482009/the-microbiota-the-gut-and-the-brain-in-eating-and-alcohol-use-disorders-a-m%C3%A3-nage-%C3%A3-trois
#6
Jamie E Temko, Sofia Bouhlal, Mehdi Farokhnia, Mary R Lee, John F Cryan, Lorenzo Leggio
Aims: Accumulating evidence for the influence of the gut microbiota on the bidirectional communication along the gut-brain axis suggests a role of the gut microbiota in eating disorders (EDs) and alcohol and substance use disorders. The potential influence of altered gut microbiota (dysbiosis) on behaviors associated with such disorders may have implications for developing therapeutic interventions. Methods: A systematic review of preclinical and clinical studies evaluating the gut microbiota, EDs and alcohol and substance use disorders was conducted using MEDLINE, Embase and Web of Science databases with the objective being to examine the role of the gut microbiota in behavioral correlates of these disorders...
May 8, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/28461690/m%C3%A3-nage-%C3%A3-trois-in-the-human-gut-interactions-between-host-bacteria-and-phages
#7
REVIEW
Mohammadali Khan Mirzaei, Corinne F Maurice
The human gut is host to one of the densest microbial communities known, the gut microbiota, which contains bacteria, archaea, viruses, fungi and other microbial eukaryotes. Bacteriophages in the gut are largely unexplored, despite their potential to regulate bacterial communities and thus human health. In addition to helping us understand gut homeostasis, applying an ecological perspective to the study of bacterial and phage communities in the gut will help us to understand how this microbial system functions...
May 2, 2017: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/28425900/mobiliser-des-repr%C3%A3-sentations-ethnoculturelles-pour-expliquer-les-disparit%C3%A3-s-d%C3%A2-acc%C3%A3-s-aux-soins-de-sant%C3%A3-au-burkina-faso
#8
Loubna Belaid, Patrick Cloos, Valéry Ridde
OBJECTIFS: Cette étude vise à décrire la mobilisation des représentations ethnoculturelles par des agents et des gestionnaires de santé pour expliquer l'échec partiel d'une politique de santé maternelle et discuter des conséquences potentielles de ces représentations sur l'accès aux soins de santé des populations.MÉTHODES : Il s'agit d'une recherche qualitative de type socio-anthropologique mobilisant des entretiens approfondis, des discussions informelles, des observations non participantes menées dans les centres de santé et une analyse documentaire...
April 20, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/28295605/peri-meatal-pein-and-urethral-scc-a-case-report
#9
LETTER
P R Doiron, H P Menage, A Freeman, A Muneer, C B Bunker
No abstract text is available yet for this article.
March 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28289745/efficient-conversion-of-alkenes-to-chlorohydrins-by-a-ru-based-artificial-enzyme
#10
Sarah Lopez, Laurianne Rondot, Christine Cavazza, Marina Iannello, Elisabetta Boeri-Erba, Nicolai Burzlaff, Frank Strinitz, Adeline Jorge-Robin, Caroline Marchi-Delapierre, Stéphane Ménage
Artificial enzymes are required to catalyse non-natural reactions. Here, a hybrid catalyst was developed by embedding a novel Ru complex in the transport protein NikA. The protein scaffold activates the bound Ru complex to produce a catalyst with high regio- and stereo-selectivity. The hybrid efficiently and stably produced α-hydroxy-β-chloro chlorohydrins from alkenes (up to 180 TON with a TOF of 1050 h(-1)).
March 14, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28285755/-the-human-and-economic-burden-of-cancer-in-france-in-2014-based-on-the-sniiram-national-database
#11
Philippe Tuppin, Laurence Pestel, Solène Samson, Anne Cuerq, Sébastien Rivière, Stéphane Tala, Pierre Denis, Jérôme Drouin, Claude Gissot, Christelle Gastaldi-Ménager, Anne Fagot-Campagna
INTRODUCTION: The national health insurance information system (Sniiram) can be used to estimate the national medical and economic burden of cancer. This study reports the annual rates, characteristics and expenditure of people reimbursed for cancer. METHODS: Among 57 million general health scheme beneficiaries (86% of the French population), people managed for cancer were identified using algorithms based on hospital diagnoses and full refund for long-term cancer...
March 9, 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/28112149/mechanotransductive-cascade-of-myo-ii-dependent-mesoderm-and-endoderm-invaginations-in-embryo-gastrulation
#12
Démosthène Mitrossilis, Jens-Christian Röper, Damien Le Roy, Benjamin Driquez, Aude Michel, Christine Ménager, Gorky Shaw, Simon Le Denmat, Laurent Ranno, Frédéric Dumas-Bouchiat, Nora M Dempsey, Emmanuel Farge
Animal development consists of a cascade of tissue differentiation and shape change. Associated mechanical signals regulate tissue differentiation. Here we demonstrate that endogenous mechanical cues also trigger biochemical pathways, generating the active morphogenetic movements shaping animal development through a mechanotransductive cascade of Myo-II medio-apical stabilization. To mimic physiological tissue deformation with a cell scale resolution, liposomes containing magnetic nanoparticles are injected into embryonic epithelia and submitted to time-variable forces generated by a linear array of micrometric soft magnets...
January 23, 2017: Nature Communications
https://www.readbyqxmd.com/read/28089380/biotic-host-pathogen-interactions-as-major-drivers-of-plastid-endosymbiosis
#13
REVIEW
Ugo Cenci, Debashish Bhattacharya, Andreas P M Weber, Christophe Colleoni, Agathe Subtil, Steven G Ball
The plastid originated 1.5 billion years ago through a primary endosymbiosis involving a heterotrophic eukaryote and an ancient cyanobacterium. Phylogenetic and biochemical evidence suggests that the incipient endosymbiont interacted with an obligate intracellular chlamydial pathogen that housed it in an inclusion. This aspect of the ménage-à-trois hypothesis (MATH) posits that Chlamydiales provided critical novel transporters and enzymes secreted by the pathogens in the host cytosol. This initiated the efflux of photosynthate to both the inclusion lumen and host cytosol...
April 2017: Trends in Plant Science
https://www.readbyqxmd.com/read/28060465/ferritin-protein-regulates-the-degradation-of-iron-oxide-nanoparticles
#14
Jeanne Volatron, Florent Carn, Jelena Kolosnjaj-Tabi, Yasir Javed, Quoc Lam Vuong, Yves Gossuin, Christine Ménager, Nathalie Luciani, Gaëlle Charron, Miryana Hémadi, Damien Alloyeau, Florence Gazeau
Proteins implicated in iron homeostasis are assumed to be also involved in the cellular processing of iron oxide nanoparticles. In this work, the role of an endogenous iron storage protein-namely the ferritin-is examined in the remediation and biodegradation of magnetic iron oxide nanoparticles. Previous in vivo studies suggest the intracellular transfer of the iron ions released during the degradation of nanoparticles to endogenous protein cages within lysosomal compartments. Here, the capacity of ferritin cages to accommodate and store the degradation products of nanoparticles is investigated in vitro in the physiological acidic environment of the lysosomes...
January 2017: Small
https://www.readbyqxmd.com/read/28057692/cdk4-6-inhibition-and-sorafenib-a-m%C3%A3-nage-%C3%A3-deux-in-hcc-therapy
#15
Diego Calvisi, Robert Eferl
No abstract text is available yet for this article.
January 5, 2017: Gut
https://www.readbyqxmd.com/read/28044965/-actin-nucleation-and-hiv-transfer-from-dendritic-cells-to-t-lymphocytes
#16
Mickaël Ménager
No abstract text is available yet for this article.
December 2016: Médecine Sciences: M/S
https://www.readbyqxmd.com/read/28029258/liposomes-for-pet-and-mr-imaging-and-for-dual-targeting-magnetic-field-glucose-moiety-synthesis-properties-and-in-vivo-studies
#17
Jérémy Malinge, Bastien Géraudie, Paul Savel, Valérie Nataf, Aurélie Prignon, Claire Provost, Yongmin Zhang, Phalla Ou, Khaldoun Kerrou, Jean-Noël Talbot, Jean-Michel Siaugue, Matthieu Sollogoub, Christine Ménager
We describe the potentiality of a new liposomal formulation enabling positron emission tomography (PET) and magnetic resonance MR() imaging. The bimodality is achieved by coupling a (68)Ga-based radiotracer on the bilayer of magnetic liposomes. In order to enhance the targeting properties obtained under a permanent magnetic field, a sugar moiety was added in the lipid formulation. Two new phospholipids were synthesized, one with a specific chelator of (68)Ga (DSPE-PEG-NODAGA) and one with a glucose moiety (DSPE-PEG-glucose)...
January 12, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28024888/optimization-of-magnetic-retention-in-the-gastrointestinal-tract-enhanced-bioavailability-of-poorly-permeable-drug
#18
Anjali Seth, David Lafargue, Cécile Poirier, Thomas Badier, Nathalie Delory, Alain Laporte, Jean-Marie Delbos, Véronique Jeannin, Jean-Manuel Péan, Christine Ménager
Oral administration of low permeable drugs remains a challenge as they do not cross biological membrane efficiently and therefore exhibit a poor bioavailability. Herein, the effect of magnetic retention on the circulation and bioavailability of magnetic beads in the gastrointestinal tract in the presence of an external magnetic field is evaluated. Retention efficiency is imaged using magnetic resonance and near infrared techniques. The effect on bioavailability is then evaluated in a pharmacokinetic study. Iron oxide nanoparticles, the drug (dipeptidyl peptidase-IV inhibitor) and a fluorophore (Alexa Fluor-750) are co-encapsulated in chitosan-alginate core-shell beads...
March 30, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28018350/m%C3%A3-nage-%C3%A3-trois-the-ratio-of-bicarbonate-to-co2-and-the-ph-regulate-the-capacity-of-neutrophils-to-form-nets
#19
Christian Maueröder, Aparna Mahajan, Susanne Paulus, Stefanie Gößwein, Jonas Hahn, Deborah Kienhöfer, Mona H Biermann, Philipp Tripal, Ralf P Friedrich, Luis E Munoz, Markus F Neurath, Christoph Becker, Georg Andreas Schett, Martin Herrmann, Moritz Leppkes
In this study, we identified and characterized the potential of a high ratio of bicarbonate to CO2 and a moderately alkaline pH to render neutrophils prone to undergo neutrophil extracellular trap (NET) formation. Both experimental settings increased the rate of spontaneous NET release and potentiated the NET-inducing capacity of phorbol esters (phorbol-2-myristate-13-acetate), ionomycin, monosodium urate, and LPS. In contrast, an acidic environment impaired NET formation both spontaneous and induced. Our findings indicate that intracellular alkalinization of neutrophils in response to an alkaline environment leads to an increase of intracellular calcium and neutrophil activation...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27972176/type-2-diabetes-how-much-does-it-cost-during-the-first-8-years-after-the-first-antidiabetic-treatment-a-dynamic-approach-from-the-french-national-health-insurance
#20
A Aguade, F Baudot, G De Lagasnerie, C Gastaldi-Menager, A Fagot-Campagna
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
keyword
keyword
87471
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"