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C Le Cossec, A-L Perrine, N Beltzer, C Fuhrman, L Carcaillon-Bentata
OBJECTIVE: To estimate the prevalence of pre-frailty, frailty and multimorbidity in individuals without disability in France. To describe independent determinants of each indicators. DESIGN: Two nationally representative cross-sectional French surveys. SETTINGS: Wave 2012 of the Health, Health Care and Insurance Survey (Enquête Santé et Protection Sociale, ESPS) and data from the Disability Healthcare Household section Survey (Enquête Handicap Santé - Ménages, HSM) from 2008...
2016: Journal of Nutrition, Health & Aging
Elizabeth Pennisi
No abstract text is available yet for this article.
July 22, 2016: Science
Clara Azemard, Matthieu Menager, Catherine Vieillescazes
The three principal types of molecules composing diterpenic resins are the abietanes, pimaranes and labdanes. The study of their fragmentation was performed by gas chromatography coupled to an ion trap mass spectrometer, on standards and resins used in paint varnishes: colophony and sandarac. We found that the general fragmentation pattern was mostly governed by the location of the double bonds on the different cycles and the presence of functional groups, and not by the nature of the C13 group in the case of abietanes and pimaranes...
September 2016: Analytical and Bioanalytical Chemistry
Charlène Esmieu, Maylis Orio, Laurent Le Pape, Colette Lebrun, Jacques Pécaut, Stéphane Ménage, Stéphane Torelli
Due to their redox capabilities, thiols have an important role in biological oxidative/reductive processes through the formation of disulfides or their oxidation to into sulfenic, sulfinic, or sulfonic derivatives being also relevant for specific enzyme activities. The mechanisms of these biological pathways often involve metal ion(s). In this case, deciphering metal-assisted transformation of the S-S bond is of primary interest. This report details the reactivity of the disulfide-containing 2,6-bis[(bis(pyridylmethyl)amino)methyl]-4-methylmercaptophenyldisulfide (L(Me(BPA)S-S)) ligand with Cu(II) using different experimental conditions (anaerobic, H2O-only, H2O/O2, or O2-only)...
June 20, 2016: Inorganic Chemistry
Elisabetta Furlanis, Peter Scheiffele
Regulation of neurotransmitter receptor localization is critical for synaptic function and plasticity. In this issue of Neuron, Matsuda and colleagues (Matsuda et al., 2016) uncover a transsynaptic complex consisting of neurexin-3, C1q-like proteins, and kainate receptors that drives glutamate receptor clustering at hippocampal synapses.
May 18, 2016: Neuron
Sean Waite, Nicole Denier
This study presents novel evidence on the relationship between sexual orientation and self-employment. Using data from the 2001 and 2006 Census of Canada and the 2011 Canadian National Household Survey, we explore the propensity for self-employment among same- and opposite-sex couples. We examine the demographic, human capital, and family characteristics of coupled gay men and lesbians relative to their coupled heterosexual counterparts to offer potential mechanisms generating differences in rates of self-employment...
May 2016: Canadian Review of Sociology, Revue Canadienne de Sociologie
Dilantha Gunawardana
Diverse cellular activities are mediated through the interaction of protein domains and their binding partners. One such protein domain widely distributed in the higher metazoan world is the PDZ domain, which facilitates abundant protein-protein interactions. The PDZ domain-PDZ binding domain interaction has been implicated in several pathologies including Alzheimer's disease, Parkinson's disease and Down syndrome. PDZ domains bind to C-terminal peptides/proteins which have either of the following combinations: S/T-X-hydrophobic-COOH for type I, hydrophobic-Xhydrophobic- COOH for type II, and D/E-X-hydrophobic-COOH for type III, although hydrophobicity in the termini form the key characteristic of the PDZ-binding domains...
2016: Protein and Peptide Letters
Jérémie Ménager, Jean-Baptiste Gorin, Nolwenn Fichou, Sébastien Gouard, Alfred Morgenstern, Frank Bruchertseifer, François Davodeau, Françoise Kraeber-Bodéré, Michel Chérel, Joëlle Gaschet, Yannick Guilloux
Alpha-radioimmunotherapy (α-RIT) is a targeted anti-tumor therapy using usually a monoclonal antibody specific for a tumor antigen that is coupled to an α-particle emitter. α-emitters represent an ideal tool to eradicate disseminated tumors or metastases. Recent data demonstrate that ionizing radiation in addition to its direct cytotoxic ability can also induce an efficient anti-tumor immunity. This suggests that biologic effects on irradiated tissues could be used to potentiate immunotherapy efficacy and opens the way for development of new therapies combining α-RIT and different types of immunotherapy...
April 2016: Médecine Sciences: M/S
Philippe Tuppin, Sébastien Rivière, Alexandre Rigault, Stéphane Tala, Jérôme Drouin, Laurence Pestel, Pierre Denis, Christelle Gastaldi-Ménager, Claude Gissot, Yves Juillière, Anne Fagot-Campagna
BACKGROUND: Cardiovascular diseases (CVDs) constitute the second leading cause of death in France. The Système national d'information interrégimes de l'assurance maladie (SNIIRAM; national health insurance information system) can be used to estimate the national medical and economic burden of CVDs. OBJECTIVES: To describe the rates, characteristics and expenditure of people reimbursed for CVDs in 2013. METHODS: Among 57 million general health scheme beneficiaries (86% of the French population), people managed for CVDs were identified using algorithms based on hospital diagnoses either during the current year (acute phase) or over the previous 5 years (chronic phase) and long-term diseases...
June 2016: Archives of Cardiovascular Diseases
T J Tull, T Toma, H P Menagé
No abstract text is available yet for this article.
August 2016: Clinical and Experimental Dermatology
Linford Briant, Albert Salehi, Elisa Vergari, Quan Zhang, Patrik Rorsman
Type 2 diabetes involves a ménage à trois of impaired glucose regulation of pancreatic hormone release: in addition to impaired glucose-induced insulin secretion, the release of the hyperglycaemic hormone glucagon becomes dysregulated; these last-mentioned defects exacerbate the metabolic consequences of hypoinsulinaemia and are compounded further by hypersecretion of somatostatin (which inhibits both insulin and glucagon secretion). Glucagon secretion has been proposed to be regulated by either intrinsic or paracrine mechanisms, but their relative significance and the conditions under which they operate are debated...
May 2016: Upsala Journal of Medical Sciences
Kristine E Ensrud, Terri L Blackwell, Howard A Fink, Jie Zhang, Jane A Cauley, Peggy M Cawthon, Dennis M Black, Douglas C Bauer, Jeffrey R Curtis, Eric S Orwoll, Elizabeth Barrett-Connor, Deborah M Kado, Lynn M Marshall, James M Shikany, John T Schousboe
To determine the proportion of incident radiographic vertebral fractures (vfx) also diagnosed as incident clinical vfx in older men and vice-versa, we used data from 4398 community-dwelling men age ≥65 years enrolled in the Osteoporotic Fractures in Men (MrOS) study. Incident radiographic vfx were identified by comparing baseline and follow-up lateral thoracic and lumbar spine study films (average 4.6 years between films) using a semiquantitative (SQ) method and defined as a change in SQ reading of ≥1 at a given vertebral level from baseline to follow-up study radiograph...
August 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Daniel A Donahue, Olivier Schwartz
Dendritic cells (DCs) capture HIV particles and transmit them to CD4 T cells. In a recent article published in Cell, Ménager and Littman (2016) perform an shRNA screen in DCs and find that actin nucleation and stabilization regulate HIV uptake and maintain the virus on membrane protrusions for efficient transfer.
March 9, 2016: Cell Host & Microbe
S Pichetti, A Penneau, P Lengagne, C Sermet
BACKGROUND: Using data from the 2008 French health and disabilities households surveys, this study examines the use of three types of routine medical care (dental, ophthalmological and gynecological care) and four preventive services (cervical cancer screening, breast cancer screening, colon cancer screening and vaccination against hepatitis B) both for people with disabilities and for those without. Two definitions of disability were retained: (1) functional limitations (motor, cognitive, visual or hearing limitations) and (2) administrative recognition of disability...
April 2016: Revue D'épidémiologie et de Santé Publique
Yann Gager, Emilia Tarland, Dietmar Lieckfeldt, Matthieu Ménage, Fidel Botero-Castro, Stephen J Rossiter, Robert H S Kraus, Arne Ludwig, Dina K N Dechmann
A fundamental condition for any work with free-ranging animals is correct species identification. However, in case of bats, information on local species assemblies is frequently limited especially in regions with high biodiversity such as the Neotropics. The bat genus Molossus is a typical example of this, with morphologically similar species often occurring in sympatry. We used a multi-method approach based on molecular, morphometric and acoustic information collected from 962 individuals of Molossus bondae, M...
2016: PloS One
P Tuppin, S Samson, N Colinot, C Gastaldi-Menager, A Fagot-Campagna, C Gissot
BACKGROUND: The objective was to investigate healthcare use among people covered by one of the two complementary healthcare insurance schemes available for people with low annual income: CMUC (universal complementary healthcare insurance) and, for people whose income exceeds the CMUC ceiling, ACS (aid for complementary healthcare insurance). Comparisons were made between CMUC and ACS beneficiaries versus CMUC and ACS non-beneficiaries and between CMUC beneficiaries and ACS beneficiaries...
April 2016: Revue D'épidémiologie et de Santé Publique
Y Wang, M J Fu, C Zhao, W Y Bao, F L Zhou, Q B Yang, S G Jiang, L H Qiu
MAT1 (ménage à trois 1), an assembly factor and targeting subunit of the CDK-dependent kinase (CAK), can regulate the cell cycle, transcription, and DNA repair. This study was intended to investigate the role of MAT1 in the reproductive maturation of black tiger shrimp (Penaeus monodon). In this study, the P. monodon MAT1 (PmMAT1) gene was identified and characterized. The full-length cDNA of PmMAT1 was 1490 bp in length with an open-reading frame of 993 bp corresponding to 330 amino acids. The temporal expression of PmMAT1 in various tissues was measured by quantitative real-time PCR with the highest expression observed in ovaries...
2016: Genetics and Molecular Research: GMR
Mickaël M Ménager, Dan R Littman
Whereas human dendritic cells (DCs) are largely resistant to productive infection with HIV-1, they have a unique ability to take up the virus and transmit it efficiently to T lymphocytes through a process of trans-infection or trans-enhancement. To elucidate the molecular and cell biological mechanism for trans-enhancement, we performed an shRNA screen of several hundred genes involved in organelle and membrane trafficking in immature human monocyte-derived dendritic cells (MDDCs). We identified TSPAN7 and DNM2, which control actin nucleation and stabilization, as having important and distinct roles in limiting HIV-1 endocytosis and in maintaining virus particles on dendrites, which is required for efficient transfer to T lymphocytes...
February 11, 2016: Cell
A Paumier, A Marquis, P Trémolières, M Lacombe, O Capitain, A-L Septans, G Peyraga, P Gustin, A Vénara, É Ménager, D Visvikis, O Couturier, E Rio, M Hatt
PURPOSE: The purpose of this study was to assess the prognostic value of different parameters on pretreatment fluorodeoxyglucose [((18)F)-FDG] positron emission tomography-computed tomography (PET-CT) in patients with localized oesophageal cancer. PATIENTS AND METHOD: We retrospectively reviewed 83 cases of localised oesophageal cancer treated in our institution. Patients were treated with curative intent and have received chemoradiotherapy alone or followed by surgery...
February 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
Marie-Thérèse Menager, Eric Ansoborlo, David Pignol
No abstract text is available yet for this article.
May 2016: Environmental Science and Pollution Research International
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