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https://www.readbyqxmd.com/read/28089380/biotic-host-pathogen-interactions-as-major-drivers-of-plastid-endosymbiosis
#1
REVIEW
Ugo Cenci, Debashish Bhattacharya, Andreas P M Weber, Christophe Colleoni, Agathe Subtil, Steven G Ball
The plastid originated 1.5 billion years ago through a primary endosymbiosis involving a heterotrophic eukaryote and an ancient cyanobacterium. Phylogenetic and biochemical evidence suggests that the incipient endosymbiont interacted with an obligate intracellular chlamydial pathogen that housed it in an inclusion. This aspect of the ménage-à-trois hypothesis (MATH) posits that Chlamydiales provided critical novel transporters and enzymes secreted by the pathogens in the host cytosol. This initiated the efflux of photosynthate to both the inclusion lumen and host cytosol...
January 11, 2017: Trends in Plant Science
https://www.readbyqxmd.com/read/28060465/ferritin-protein-regulates-the-degradation-of-iron-oxide-nanoparticles
#2
Jeanne Volatron, Florent Carn, Jelena Kolosnjaj-Tabi, Yasir Javed, Quoc Lam Vuong, Yves Gossuin, Christine Ménager, Nathalie Luciani, Gaëlle Charron, Miryana Hémadi, Damien Alloyeau, Florence Gazeau
Proteins implicated in iron homeostasis are assumed to be also involved in the cellular processing of iron oxide nanoparticles. In this work, the role of an endogenous iron storage protein-namely the ferritin-is examined in the remediation and biodegradation of magnetic iron oxide nanoparticles. Previous in vivo studies suggest the intracellular transfer of the iron ions released during the degradation of nanoparticles to endogenous protein cages within lysosomal compartments. Here, the capacity of ferritin cages to accommodate and store the degradation products of nanoparticles is investigated in vitro in the physiological acidic environment of the lysosomes...
January 2017: Small
https://www.readbyqxmd.com/read/28057692/cdk4-6-inhibition-and-sorafenib-a-m%C3%A3-nage-%C3%A3-deux-in-hcc-therapy
#3
Diego Calvisi, Robert Eferl
No abstract text is available yet for this article.
January 5, 2017: Gut
https://www.readbyqxmd.com/read/28044965/-actin-nucleation-and-hiv-transfer-from-dendritic-cells-to-t-lymphocytes
#4
Mickaël Ménager
No abstract text is available yet for this article.
December 2016: Médecine Sciences: M/S
https://www.readbyqxmd.com/read/28029258/liposomes-for-pet-and-mr-imaging-and-for-dual-targeting-magnetic-field-glucose-moiety-synthesis-properties-and-in-vivo-studies
#5
Jeremy Malinge, Bastien Géraudie, Paul Savel, Valerie Nataf, Aurelie Prignon, Claire Provost, Yongmin Zhang, Phalla Ou, Khaldoun Kerrou, Jean-Noel Talbot, Jean-Michel Siaugue, Matthieu Sollogoub, Christine Menager
We describe the potentiality of a new liposomal formulation enabling PET and MR imaging for cancer diagnosis. The bimodality is achieved by coupling a 68Ga-based radiotracer on the bilayer of ultra magnetic liposomes. In order to enhance the targeting properties obtained under a permanent magnetic field, a sugar moiety was added in the lipid formulation. Two new phospholipids were synthesized, one with a specific chelator of 68Ga (DSPE-PEG-NODAGA) and one with a glucose moiety (DSPE-PEG-Glucose). The liposomes were produced according to a fast and safe process, with a high radiolabeling yield...
December 28, 2016: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28024888/optimization-of-magnetic-retention-in-the-gastrointestinal-tract-enhanced-bioavailability-of-poorly-permeable-drug
#6
Anjali Seth, David Lafargue, Cécile Poirier, Thomas Badier, Nathalie Delory, Alain Laporte, Jean-Marie Delbos, Véronique Jeannin, Jean-Manuel Péan, Christine Ménager
Oral administration of low permeable drugs remains a challenge as they do not cross biological membrane efficiently and therefore exhibit a poor bioavailability. Herein, the effect of magnetic retention on the circulation and bioavailability of magnetic beads in the gastrointestinal tract in the presence of an external magnetic field is evaluated. Retention efficiency is imaged using magnetic resonance and near infrared techniques. The effect on bioavailability is then evaluated in a pharmacokinetic study. Iron oxide nanoparticles, the drug (dipeptidyl peptidase-IV inhibitor) and a fluorophore (Alexa Fluor-750) are co-encapsulated in chitosan-alginate core-shell beads...
December 24, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28018350/m%C3%A3-nage-%C3%A3-trois-the-ratio-of-bicarbonate-to-co2-and-the-ph-regulate-the-capacity-of-neutrophils-to-form-nets
#7
Christian Maueröder, Aparna Mahajan, Susanne Paulus, Stefanie Gößwein, Jonas Hahn, Deborah Kienhöfer, Mona H Biermann, Philipp Tripal, Ralf P Friedrich, Luis E Munoz, Markus F Neurath, Christoph Becker, Georg Andreas Schett, Martin Herrmann, Moritz Leppkes
In this study, we identified and characterized the potential of a high ratio of bicarbonate to CO2 and a moderately alkaline pH to render neutrophils prone to undergo neutrophil extracellular trap (NET) formation. Both experimental settings increased the rate of spontaneous NET release and potentiated the NET-inducing capacity of phorbol esters (phorbol-2-myristate-13-acetate), ionomycin, monosodium urate, and LPS. In contrast, an acidic environment impaired NET formation both spontaneous and induced. Our findings indicate that intracellular alkalinization of neutrophils in response to an alkaline environment leads to an increase of intracellular calcium and neutrophil activation...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27972176/type-2-diabetes-how-much-does-it-cost-during-the-first-8-years-after-the-first-antidiabetic-treatment-a-dynamic-approach-from-the-french-national-health-insurance
#8
A Aguade, F Baudot, G De Lagasnerie, C Gastaldi-Menager, A Fagot-Campagna
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27970463/economic-burden-of-diseases-in-france-analysing-the-trends-from-2012-to-2014-using-the-french-health-insurance-database-sniiram
#9
C Gastaldi Menager, J Drouin, L Pestel, A Fagot-Campagna, C Gissot
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27917534/a-concept-analysis-of-compassionate-midwifery
#10
Diane Ménage, Elizabeth Bailey, Susan Lees, Jane Coad
AIM: To report a concept analysis of compassionate midwifery. BACKGROUND: Recently, compassion has been incorporated into United Kingdom nursing and midwifery language through strategy, policy, recruitment and education. Professional standards direct midwives to practise compassionately therefore the concept of compassionate midwifery exists, although this has yet to be explored as a concept in the UK or internationally. An understanding of what constitutes compassionate midwifery has the potential to increase midwifery knowledge and improve practice...
November 16, 2016: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/27882718/catching-up-or-falling-behind-continuing-wealth-disparities-for-immigrants-to-canada-by-region-of-origin-and-cohort
#11
Michelle Maroto, Laura Aylsworth
This paper investigates wealth disparities among first-generation immigrants using data from the 2012 Survey of Financial Security. We apply logistic and linear regression models to estimate disparities in homeownership and household equivalent net worth by immigrant status, region of origin, and time since arrival. By focusing on immigrant families from different regions who entered Canada at different points in time, this research applies theories related to assimilation, human capital, and structural barriers to wealth...
November 2016: Canadian Review of Sociology, Revue Canadienne de Sociologie
https://www.readbyqxmd.com/read/27876650/viruses-of-parasites-as-actors-in-the-parasite-host-relationship-a-m%C3%A3-nage-%C3%A3-trois
#12
REVIEW
Amaranta Gómez-Arreaza, Anne-Lise Haenni, Irene Dunia, Luisana Avilán
The complex parasite-host relationship involves multiple mechanisms. Moreover, parasites infected by viruses modify this relationship adding more complexity to the system that now comprises three partners. Viruses infecting parasites were described several decades ago. However, until recently little was known about the viruses involved and their impact on the resulting disease caused to the hosts. To clarify this situation, we have concentrated on parasitic diseases caused to humans and on how virus-infected parasites could alter the symptoms inflicted on the human host...
February 2017: Acta Tropica
https://www.readbyqxmd.com/read/27862540/buchnera-has-changed-flatmate-but-the-repeated-replacement-of-co-obligate-symbionts-is-not-associated-with-the-ecological-expansions-of-their-aphid-hosts
#13
A S Meseguer, A Manzano-Marín, A Coeur d'Acier, A-L Clamens, M Godefroid, E Jousselin
Symbiotic associations with bacteria have facilitated important evolutionary transitions in insects and resulted in long-term obligate interactions. Recent evidence suggests that these associations are not always evolutionarily stable and that symbiont replacement, and/or supplementation of an obligate symbiosis by an additional bacterium, has occurred during the history of many insect groups. Yet, the factors favouring one symbiont over another in this evolutionary dynamic are not well understood; progress has been hindered by our incomplete understanding of the distribution of symbionts across phylogenetic and ecological contexts...
November 14, 2016: Molecular Ecology
https://www.readbyqxmd.com/read/27817977/midwives-experiences-of-referring-obese-women-to-either-a-community-or-home-based-antenatal-weight-management-service-implications-for-service-providers-and-midwifery-practice
#14
Lou Atkinson, David P French, Diane Ménage, Ellinor K Olander
OBJECTIVE: a variety of services to support women to undertake weight management behaviours during pregnancy have recently been implemented as a means to reduce the risks to mother and infant. In the UK, midwives lead the care of the majority of pregnant women and are seen as the ideal source of referral into antenatal services. However, midwives have reported concerns regarding raising the topic of weight with obese women and negative referral experiences have been cited as a reason not to engage with a service...
October 22, 2016: Midwifery
https://www.readbyqxmd.com/read/27787518/glioblastoma-hypoxia-and-autophagy-a-survival-prone-m%C3%A3-nage-%C3%A3-trois
#15
REVIEW
Soha Jawhari, Marie-Hélène Ratinaud, Mireille Verdier
Glioblastoma multiforme is the most common and the most aggressive primary brain tumor. It is characterized by a high degree of hypoxia and also by a remarkable resistance to therapy because of its adaptation capabilities that include autophagy. This degradation process allows the recycling of cellular components, leading to the formation of metabolic precursors and production of adenosine triphosphate. Hypoxia can induce autophagy through the activation of several autophagy-related proteins such as BNIP3, AMPK, REDD1, PML, and the unfolded protein response-related transcription factors ATF4 and CHOP...
October 27, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27709236/pre-frailty-frailty-and-multimorbidity-prevalences-and-associated-characteristics-from-two-french-national-surveys
#16
C Le Cossec, A-L Perrine, N Beltzer, C Fuhrman, L Carcaillon-Bentata
OBJECTIVE: To estimate the prevalence of pre-frailty, frailty and multimorbidity in individuals without disability in France. To describe independent determinants of each indicators. DESIGN: Two nationally representative cross-sectional French surveys. SETTINGS: Wave 2012 of the Health, Health Care and Insurance Survey (Enquête Santé et Protection Sociale, ESPS) and data from the Disability Healthcare Household section Survey (Enquête Handicap Santé - Ménages, HSM) from 2008...
2016: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/27463653/symbiosis-a-lichen-m%C3%A3-nage-%C3%A3-trois
#17
Elizabeth Pennisi
No abstract text is available yet for this article.
July 22, 2016: Science
https://www.readbyqxmd.com/read/27449645/analysis-of-diterpenic-compounds-by-gc-ms-ms-contribution-to-the-identification-of-main-conifer-resins
#18
Clara Azemard, Matthieu Menager, Catherine Vieillescazes
The three principal types of molecules composing diterpenic resins are the abietanes, pimaranes and labdanes. The study of their fragmentation was performed by gas chromatography coupled to an ion trap mass spectrometer, on standards and resins used in paint varnishes: colophony and sandarac. We found that the general fragmentation pattern was mostly governed by the location of the double bonds on the different cycles and the presence of functional groups, and not by the nature of the C13 group in the case of abietanes and pimaranes...
September 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27268152/redox-innocent-metal-assisted-cleavage-of-s-s-bond-in-a-disulfide-containing-ligand
#19
Charlène Esmieu, Maylis Orio, Laurent Le Pape, Colette Lebrun, Jacques Pécaut, Stéphane Ménage, Stéphane Torelli
Due to their redox capabilities, thiols have an important role in biological oxidative/reductive processes through the formation of disulfides or their oxidation to into sulfenic, sulfinic, or sulfonic derivatives being also relevant for specific enzyme activities. The mechanisms of these biological pathways often involve metal ion(s). In this case, deciphering metal-assisted transformation of the S-S bond is of primary interest. This report details the reactivity of the disulfide-containing 2,6-bis[(bis(pyridylmethyl)amino)methyl]-4-methylmercaptophenyldisulfide (L(Me(BPA)S-S)) ligand with Cu(II) using different experimental conditions (anaerobic, H2O-only, H2O/O2, or O2-only)...
June 20, 2016: Inorganic Chemistry
https://www.readbyqxmd.com/read/27196968/synaptic-m%C3%A3-nage-%C3%A3-trois
#20
Elisabetta Furlanis, Peter Scheiffele
Regulation of neurotransmitter receptor localization is critical for synaptic function and plasticity. In this issue of Neuron, Matsuda and colleagues (Matsuda et al., 2016) uncover a transsynaptic complex consisting of neurexin-3, C1q-like proteins, and kainate receptors that drives glutamate receptor clustering at hippocampal synapses.
May 18, 2016: Neuron
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