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https://www.readbyqxmd.com/read/29032273/torquetenovirus-dynamics-and-immune-marker-properties-in-patients-following-allogeneic-hematopoietic-stem-cell-transplantation-a-prospective-longitudinal-study
#1
Philipp Wohlfarth, Michael Leiner, Christian Schoergenhofer, Georg Hopfinger, Irene Goerzer, Elisabeth Puchhammer-Stoeckl, Werner Rabitsch
BACKGROUND: Torquetenovirus (TTV) has been proposed as a marker of immune function in patients receiving immunosuppression after solid organ transplantation. This study aimed to define TTV plasma dynamics and investigate clinical associations in patients following allogeneic hematopoietic stem cell transplantation (HSCT). METHODS: Single-center prospective longitudinal study involving 50 consecutive patients treated with HSCT between March 2015 and April 2016. TTV plasma DNA levels were measured with quantitative PCR on twelve consecutive timepoints during the first year following HSCT...
October 12, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28993019/a-modified-formula-for-dose-calculations-of-stereotactic-ablative-body-radiotherapy-for-non-small-cell-lung-cancer
#2
Yangsen Cao, Xiaofei Zhu, Yu Zhang, Chunshan Yu, Yongming Liu, Yongjian Sun, Zhitao Dai, Xueling Guo, Xiaoping Ju, Huojun Zhang
To provide a modified formula consistent with the Monte Carlo (MC) algorithm for dose calculations during stereotactic ablative body radiotherapy for non-small cell lung cancer. Seventy CyberKnife treatment plans were calculated and analyzed by MC and ray-tracing (RT) algorithms, separately. Parameters of treatment plans were compared, and those associated with differences of dose distributions were analyzed to establish a modified formula. Gross tumor volume and tumor tracking volume (TTV) were defined as the evident disease on the sequences of the window width and level of the lung and the mediastinum...
October 6, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28972950/phylogenetic-analysis-of-torque-teno-virus-in-thalassemic-children-in-egypt
#3
Noha A Hassuna, Eman Naguib, Medhat Abdel-Fatah, Suzan M Omar Mousa
OBJECTIVE: Torque teno virus (TTV) is a ubiquitous virus that is commonly associated with blood transfusion. The main aims of this study were to evaluate the incidence of TTV in polytransfused children with thalassemia and to determine for the first time the prevalent TTV genotypes in Egypt. METHODS: TTV was detected in 2 groups by nested PCR: the first group comprised 200 children with thalassemia, and the second included age- and sex-matched healthy children with no history of blood transfusion...
October 4, 2017: Intervirology
https://www.readbyqxmd.com/read/28966070/prevalence-of-occult-hepatitis-b-virus-infection-and-torque-teno-virus-infection-and-their-association-with-hepatocellular-carcinoma-in-chronic-hepatitis-c-patients
#4
Agatha S Rosa, Oscar C Araujo, Flavia Savassi-Ribas, Carlos A Fernandes, Henrique S Coelho, Christian Niel, Cristiane A Villela-Nogueira, Natalia M Araujo
BACKGROUND: The role of occult hepatitis B virus (HBV) infection and Torque teno virus (TTV) infection in the development of hepatocellular carcinoma (HCC) in chronic hepatitis C patients is still uncertain. AIM: The aim of the present study was to investigate the prevalence and significance of OBI and TTV infection, and to examine the genetic diversity of these viruses, in chronic hepatitis C patients with and without HCC. METHODS: Sera from 151 hepatitis C virus (HCV)-infected patients (49 patients with HCC and 102 without HCC) negative for HBV surface antigen (HBsAg) were tested for the presence of OBI and TTV infection by semi-nested and group-specific multiplex PCR assays, respectively...
September 29, 2017: Virus Research
https://www.readbyqxmd.com/read/28868270/torque-teno-virus-ttv-among-%C3%AE-thalassemia-and-haemodialysis-patients-in-mazandaran-province-north-of-iran
#5
Hossein Jalali, Mohammad Reza Mahdavi, Najmeh Zaeromali
Torque Teno virus (TTV) is a transfusion transmitted virus that seems to be involved in several complications such as acute respiratory diseases, liver diseases, AIDS, cancer, and autoimmune reactions. In the present study the frequency of TTV was investigated among β- thalassemia (BT) and haemodialysis (HD) patients (high risk patients for TTV) in Mazandaran province, Iran. DNA was extracted from the serum of 82 BT and 100 HD patients, and nested PCR method was applied to detect TTV DNA. The aspartate transaminase(AST) and alanine transaminase (ALT) enzyme levels in BT patients were measured using photometric assay...
2017: International Journal of Molecular and Cellular Medicine
https://www.readbyqxmd.com/read/28846911/testicular-volumetry-and-prediction-of-daily-sperm-output-in-stallions-by-orchidometry-and-two-and-three-dimensional-sonography
#6
S Pricking, H Bollwein, K Spilker, G Martinsson, A Schweizer, S Thomas, H Oldenhof, H Sieme
Accurate determination of the testes volume and prediction of the daily sperm output (DSO) is valuable information for reproductive management of a stallion. The aim of this study was to compare different methods for measuring the testes volume, including caliper, 2D and 3D ultrasound. Special emphasis was on feasibility of 3D volume analysis. First, 22 castrated testes were measured and derived volumes were compared with volumes determined via volume displacement in a graded cylinder with saline solution. Then, during the breeding season, testes sizes of 52 stallions were measured in vivo and analyzed...
August 19, 2017: Theriogenology
https://www.readbyqxmd.com/read/28754109/prognostic-value-of-total-tumor-volume-in-patients-with-nasopharyngeal-carcinoma-treated-with-intensity-modulated-radiotherapy
#7
Shao-Bo Liang, Jian-Jian Teng, Xue-Feng Hu, Xing-Li Yang, Min Luo, Xiao-Na Fang, Dong-Sheng Liu, Yong Chen, Li-Wu Fu
BACKGROUND: Few studies have evaluated the prognostic value of total tumor volume (TTV), which reflects both the primary tumor volume and nodal tumor volume, in NPC. Furthermore, the relationship between TTV and survival remains unknown. The purpose of this study was to evaluate the prognostic value of TTV in patients with NPC treated with intensity-modulated radiation therapy (IMRT). METHODS: TTV was retrospectively assessed in 455 patients with newly diagnosed, non-metastatic NPC...
July 28, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28750638/erratum-to-prevalence-of-anelloviruses-ttv-ttmdv-and-ttmv-in-healthy-blood-donors-and-in-patients-infected-with-hbv-or-hcv-in-qatar
#8
Ahmed A Al-Qahtani, Enas S Alabsi, Raed AbuOdeh, Lukman Thalib, Mohamed E El Zowalaty, Gheyath K Nasrallah
No abstract text is available yet for this article.
July 27, 2017: Virology Journal
https://www.readbyqxmd.com/read/28710997/dynamics-of-torque-teno-virus-plasma-dnaemia-in-allogeneic-stem-cell-transplant-recipients
#9
Eliseo Albert, Carlos Solano, Tania Pascual, Ignacio Torres, Lisa Macera, Daniele Focosi, Fabrizio Maggi, Estela Giménez, Paula Amat, David Navarro
BACKGROUND: Torque Teno virus (TTV) plasma DNA load directly correlate with the level of immunosuppresion in different clinical settings. It is uncertain whether this may be the case in allogeneic hematopoietic stem cell transplant recipients (allo-HSCT). OBJECTIVES: We characterized the dynamics of TTV DNAemia in patients undergoing T-cell replete allo-SCT. STUDY DESIGN: Retrospective single-center observational study including 72 allo-HSCT patients...
July 8, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28702856/dynamics-of-torque-teno-virus-viremia-could-predict-risk-of-complications-after-allogeneic-hematopoietic-stem-cell-transplantation
#10
Ramona Gilles, Marco Herling, Udo Holtick, Eva Heger, Sabine Awerkiew, Irina Fish, Konstantin Höller, Saleta Sierra, Elena Knops, Rolf Kaiser, Christof Scheid, Veronica Di Cristanziano
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an established treatment option for several hematological diseases. However, the first year post-transplantation is often complicated by infections and graft-versus-host disease (GVHD). Improvements in immunological monitoring could reduce such post-transplant complications. Torque Teno virus (TTV), a chronically persisting DNA virus, is reported to be a marker for immune function in immunocompromised patients. In the present study, the TTV kinetics were analyzed to investigate the potential role of TTV viremia as immune-competence read-out after allo-HSCT...
July 12, 2017: Medical Microbiology and Immunology
https://www.readbyqxmd.com/read/28542207/metagenomic-sequencing-complements-routine-diagnostics-in-identifying-viral-pathogens-in-lung-transplant-recipients-with-unknown-etiology-of-respiratory-infection
#11
Dagmara W Lewandowska, Peter W Schreiber, Macé M Schuurmans, Bettina Ruehe, Osvaldo Zagordi, Cornelia Bayard, Michael Greiner, Fabienne D Geissberger, Riccarda Capaul, Andrea Zbinden, Jürg Böni, Christian Benden, Nicolas J Mueller, Alexandra Trkola, Michael Huber
BACKGROUND: Lung transplant patients are a vulnerable group of immunosuppressed patients that are prone to frequent respiratory infections. We studied 60 episodes of respiratory symptoms in 71 lung transplant patients. Almost half of these episodes were of unknown infectious etiology despite extensive routine diagnostic testing. METHODS: We re-analyzed respiratory samples of all episodes with undetermined etiology in order to detect potential viral pathogens missed/not accounted for in routine diagnostics...
2017: PloS One
https://www.readbyqxmd.com/read/28527409/molecular-characterization-of-pigeon-torque-teno-virus-pttv-in-jiangsu-province
#12
Zhicheng Zhang, Wei Dai, Dingzhen Dai
The torque teno virus (TTV) is a recently discovered DNA virus that has been detected in many different hosts, including humans, livestock and poultry. To date, there is no report of pigeon TTV (PTTV) from anywhere in the world. To investigate the distribution of PTTV in pigeons from the eastern Chinese province of Jiangsu and characterize their genomes, we employed PCR to detect PTTV in 144 samples collected from 6 pigeon plants in Jiangsu province, amplify complete genomes from representative samples and analyze genetic characteristics using bioinformatics...
May 6, 2017: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/28489804/comparison-of-learning-performance-of-2-intubating-laryngeal-mask-airways-in-novice-a-randomized-crossover-manikin-study
#13
RANDOMIZED CONTROLLED TRIAL
Zi-Jia Liu, Jie Yi, Wei-Yun Chen, Xiu-Hua Zhang, Yu-Guang Huang
BACKGROUND: Intubating laryngeal mask airways (LMAs) such as i-gel and Aura-i could serve as rescue devices in resuscitation and further ensure the airway by facilitating trachea intubation without ventilation interruption. But data regarding intubating LMAs in novice are limited and skill degeneration without regular training has not been evaluated. So we designed this prospective randomized crossover manikin study to compare the learning performance of 2 intubating LMAs (i-gel and Aura-i)...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28482844/transplacental-transmission-of-torque-teno-virus
#14
Elena A Tyschik, Sophia M Shcherbakova, Ruslan R Ibragimov, Denis V Rebrikov
BACKGROUND: TTV has been detected in almost every human tissue type or body fluid reaching near 100% prevalence. Several studies report mother-to-child postnatal transmission of TTV in infancy but the risk of transplacental transmission of TTV is still unclear. METHODS: The blood and plasma collected postpartum from 100 mother-child pairs were analyzed using TTV-specific qPCR. Samples were collected from the peripheral vein of the mother and the umbilical cord. RESULTS: Eighty four percent of pregnant women were TTV positive (median titers: 8 × 10(4) copies/mL; range: 10(3) - 3 × 10(7))...
May 8, 2017: Virology Journal
https://www.readbyqxmd.com/read/28169509/nonalcoholic-fatty-liver-disease-and-measures-of-early-brain-health-in-middle-aged-adults-the-cardia-study
#15
Lisa B VanWagner, James G Terry, Lisa S Chow, Amy C Alman, Hakmook Kang, Katherine H Ingram, Christina Shay, Cora E Lewis, R Nick Bryan, Lenore J Launer, J Jeffrey Carr
OBJECTIVE: To assess associations between nonalcoholic fatty liver disease (NAFLD) and measures of brain health in a population-based sample of adults. METHODS: Participants from the CARDIA study (Y25 exam; age 43-55 years) with concurrent computed tomography quantification of liver fat, visceral adipose tissue (VAT), and brain magnetic resonance (MR) images were included (n = 505). NAFLD was identified after exclusion of other causes of liver fat. Total tissue volume (TTV) and gray matter cerebral blood flow (GM-CBF) were estimated using 3T brain MR images...
March 2017: Obesity
https://www.readbyqxmd.com/read/28130627/crescent-pyramid-and-drop-set-systems-do-not-promote-greater-strength-gains-muscle-hypertrophy-and-changes-on-muscle-architecture-compared-with-traditional-resistance-training-in-well-trained-men
#16
RANDOMIZED CONTROLLED TRIAL
Vitor Angleri, Carlos Ugrinowitsch, Cleiton Augusto Libardi
PURPOSE: The aim of this study was to compare the effects of crescent pyramid (CP) and drop-set (DS) systems with traditional resistance training (TRAD) with equalized total training volume (TTV) on maximum dynamic strength (1-RM), muscle cross-sectional area (CSA), pennation angle (PA), and fascicle length (FL). METHODS: Thirty-two volunteers had their legs randomized in a within-subject design in TRAD (3-5 sets of 6-12 repetitions at 75% 1-RM), CP (3-5 sets of 6-15 repetitions at 65-85% 1-RM), and DS (3-5 sets of ~50-75% 1-RM to muscle failure) protocols...
February 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28031027/prevalence-of-anelloviruses-ttv-ttmdv-and-ttmv-in-healthy-blood-donors-and-in-patients-infected-with-hbv-or-hcv-in-qatar
#17
Ahmed A Al-Qahtani, Enas S Alabsi, Raed AbuOdeh, Lukman Thalib, Mohamed E El Zowalaty, Gheyath K Nasrallah
BACKGROUND: Anelloviruses (TTV, TTMV, and TTMDV) have been associated with non A-G hepatitis. The goal of the current study was to estimate the prevalence of these anelloviruses in Qatar. METHODS: A total of 607 blood samples (500 healthy donors, and 53 HBV-and 54 HCV-positive patients) representing different nationalities were tested for the presence of TTV, TTMV, and TTMDV DNA by nested PCR. RESULTS: Prevalence rates for the three viruses were high in all studied groups, and exceeding 95% in the HBV group (for TTV and TTMDV)...
December 28, 2016: Virology Journal
https://www.readbyqxmd.com/read/27986348/updated-outcome-and-analysis-of-tumor-response-in-mobile-spine-and-sacral-chordoma-treated-with-definitive-high-dose-photon-proton-radiation-therapy
#18
Peyman Kabolizadeh, Yen-Lin Chen, Norbert Liebsch, Francis J Hornicek, Joseph H Schwab, Edwin Choy, Daniel I Rosenthal, Andrzej Niemierko, Thomas F DeLaney
PURPOSE: Treatment of spine and sacral chordoma generally involves surgical resection, usually in conjunction with radiation therapy. In certain circumstances where resection may result in significant neurologic or organ dysfunction, patients can be treated definitively with radiation therapy alone. Herein, we report the outcome and the assessment of tumor response to definitive radiation therapy. METHODS AND MATERIALS: A retrospective analysis was performed on 40 patients with unresected chordoma treated with photon/proton radiation therapy...
February 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27924796/detection-and-phylogenetic-analysis-of-torque-teno-virus-in-salivary-and-tumor-biopsy-samples-from-head-and-neck-carcinoma-patients
#19
Andrea Hettmann, Anett Demcsák, Ádám Bach, Gábor Decsi, Ágnes Dencs, Dóra Pálinkó, László Rovó, Katalin Nagy, Janos Minarovits, Mária Takács
OBJECTIVES: Because torque teno virus (TTV) has been implicated in tumorigenesis as a cocarcinogen, we studied TTV prevalence in saliva and biopsy samples from head and neck cancer (HNCC) patients, patients with premalignant lesions of oral cancer, and controls. We also wished to determine the TTV genotypes in HNCC patients. METHODS: A seminested polymerase chain reaction (PCR) amplifying the N22 region of the TTV genome, as well as direct sequencing of PCR fragments, was used...
2016: Intervirology
https://www.readbyqxmd.com/read/27878979/prevalence-of-the-novel-torque-teno-sus-virus-species-k2b-from-pigs-in-the-united-states-and-lack-of-association-with-post-weaning-multisystemic-wasting-syndrome-or-mulberry-heart-disease
#20
A J Rogers, Y-W Huang, C L Heffron, T Opriessnig, A R Patterson, X-J Meng
The family Anelloviridae includes a number of viruses infecting humans (Torque teno viruses, TTV) and other animals including swine (Torque teno sus viruses, TTSuV). Two genetically distinct TTSuV species have been identified from swine thus far (TTSuV1 and TTSuVk2), although their definitive association with disease remains debatable. In 2012, a novel TTSuV species was identified from commercial swine serum and classified in the genus Kappatorquevirus as TTSuVk2b. The other Kappatorquevirus species, TTSuVk2a, has been associated with post-weaning multisystemic wasting syndrome (PMWS) when coinfected with porcine circovirus type 2 (PCV2)...
November 23, 2016: Transboundary and Emerging Diseases
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