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https://www.readbyqxmd.com/read/27648373/the-benefit-of-personalized-hybrid-spect-ct-pulmonary-imaging
#1
Milan Simanek, Pavel Koranda
Hybrid pulmonary imaging in the present day has seen a fusion of various uses of CT scans, including angiography (CTAG), diagnostic CT, low dose CT (LDCT), and perfusion or ventilation scintigraphy in tomographic or planar imaging. Determining the most effective individualized test for the complete diagnostics of patients with pulmonary symptoms for various groups of patients is a major issue. The aim of the present study was to assess the effectiveness of the implementation of hybrid imaging in current methods of nuclear medicine in differential diagnostics of pulmonary embolism (PE)...
2016: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27637724/functional-image-guided-radiotherapy-planning-for-normal-lung-avoidance
#2
R H Ireland, B A Tahir, J M Wild, C E Lee, M Q Hatton
For patients with lung cancer undergoing curative intent radiotherapy, functional lung imaging can be incorporated into treatment planning to modify the dose distribution within non-target volume lung by differentiation of lung regions that are functionally defective or viable. This concept of functional image-guided lung avoidance treatment planning has been investigated with several imaging modalities, primarily single photon emission computed tomography (SPECT), but also hyperpolarised gas magnetic resonance (MR) imaging, positron emission tomography (PET) and computed tomography (CT)-based measures of lung biomechanics...
November 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/27620309/radionuclide-diagnosis-of-pulmonary-embolism
#3
Søren Hess, Poul Henning Madsen
Diagnostic imaging plays an integral role in the diagnostic workup of suspected pulmonary embolism, and several modalities have been employed over the years. In recent years, the choice has been narrowed to either computer tomographic or radionuclide based methods, i.e. computer tomographic angiography (CTA) and ventilation-perfusion scintigraphy (V/Q-scan). Both methods display advantages and shortcomings, and while we provide some insights into CTA and alternative methods, the paper's main focus is a review of the V/Q-scan...
September 13, 2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27553468/-68-ga-pet-ventilation-and-perfusion-lung-imaging-current-status-and-future-challenges
#4
REVIEW
Dale L Bailey, Enid M Eslick, Geoffrey P Schembri, Paul J Roach
Gallium-68 ((68)Ga) is a positron-emitting radionuclide suitable for positron emission tomography (PET) imaging that has a number of convenient features-it has a physical half life of 68 minutes, it is generator produced at the PET facility and needs no local cyclotron, and being a radiometal is able to be chelated to a number of useful molecules for diagnostic imaging with PET. (68)Ga has recently been investigated as a radiotracer for ventilation and perfusion (V/Q) lung imaging. It is relatively easy to produce both V/Q radiopharmaceuticals labeled with (68)Ga for PET studies, it offers higher spatial resolution than equivalent SPECT studies, the short half life allows for multiple (repeated) scans on the same day, and low amounts of radiotracer can be used thus limiting the radiation dose to the subject...
September 2016: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/27540433/vertebral-uptake-of-tc-99m-macroaggregated-albumin-maa-with-spect-ct-occurring-in-superior-vena-cava-obstruction
#5
Shawn Karls, Hani Hassoun, Vilma Derbekyan
A 67-year-old male presented with dyspnea for which lung scintigraphy was ordered to rule out pulmonary embolus. Planar images demonstrated abnormal midline uptake of Tc-99m macroaggregated albumin, which SPECT/CT localized to several thoracic vertebrae. Thoracic vertebral uptake on perfusion lung scintigraphy was previously described on planar imaging. Radionuclide venography and contrast-enhanced CT subsequently demonstrated superior vena cava (SVC) obstruction with collateralization through the azygous/hemiazygous system and vertebral venous plexus...
September 2016: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27523813/contrast-enhanced-ct-and-mri-based-perfusion-assessment-for-pulmonary-diseases-basics-and-clinical-applications
#6
Yoshiharu Ohno, Hisanobu Koyama, Ho Yun Lee, Sachiko Miura, Takeshi Yoshikawa, Kazuro Sugimura
Assessment of regional pulmonary perfusion as well as nodule and tumor perfusions in various pulmonary diseases are currently performed by means of nuclear medicine studies requiring radioactive macroaggregates, dual-energy computed tomography (CT), and dynamic first-pass contrast-enhanced perfusion CT techniques and unenhanced and dynamic first-pass contrast enhanced perfusion magnetic resonance imaging (MRI), as well as time-resolved three-dimensional or four-dimensional contrast-enhanced magnetic resonance angiography (MRA)...
September 2016: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/27461384/spect-ct-vq-versus-ctpa-for-diagnosing-pulmonary-embolus-and-other-lung-pathology-pre-existing-lung-disease-should-not-be-a-contraindication
#7
Kartik Dev Bhatia, Chaitanya Ambati, Rajiv Dhaliwal, Royce Paschkewitz, Eugene Hsu, Bao Ho, Andy Young, Louise Emmett
INTRODUCTION: Single Photon Emission Computed Tomography-Ventilation-Perfusion (SPECT-VQ) with low-dose CT (SPECT-CT/VQ) has equivalent diagnostic accuracy to CTPA for diagnosing pulmonary embolus (PE) while using lower radiation doses, but is underutilized owing to perceived inaccuracy of scintigraphy in the setting of pre-existing lung disease. This study assesses the accuracy of SPECT-CT/VQ compared with CTPA for the diagnosis of PE, including in patients with pre-existing lung disease...
August 2016: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/27368528/systemic-and-regional-pulmonary-function-after-segmentectomy
#8
Hiroaki Nomori, Yue Cong, Hiroshi Sugimura
OBJECTIVE: Segmentectomy includes numerous kinds of procedures that may result in decreased postoperative pulmonary function. This causes controversy regarding the functional advantage of segmentectomy over lobectomy. To clarify the difference between the procedures, systemic and regional pulmonary functions of the resected segments must be examined. METHODS: Pulmonary function tests and lung perfusion single-photon emission computed tomography (SPECT) were prospectively conducted before and after segmentectomy in 117 patients who were divided into groups based on resection of <2 segments (n = 83), ≥2 segments (n = 20), and left upper division (LUD) (n = 14)...
September 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27295657/fully-automated-data-driven-respiratory-signal-extraction-from-spect-images-using-laplacian-eigenmaps
#9
James C Sanders, Philipp Ritt, Torsten Kuwert, A Hans Vija, Andreas K Maier
We propose a data-driven method for extracting a respiratory surrogate signal from SPECT list-mode data. The approach is based on dimensionality reduction with Laplacian Eigenmaps. By setting a scale parameter adaptively and adding a series of post-processing steps to correct polarity and normalization between projections, we enable fully-automatic operation and deliver a respiratory surrogate signal for the entire SPECT acquisition. We validated the method using 67 patient scans from three acquisition types (myocardial perfusion, liver shunt diagnostic, lung inhalation/perfusion) and an Anzai pressure belt as a gold standard...
June 7, 2016: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/27256350/predicting-exercise-capacity-after-lobectomy-by-single-photon-emission-computed-tomography-and-computed-tomography
#10
Yoshinori Nagamatsu, Susumu Sueyoshi, Hiroko Sasahara, Yousuke Oka, Hiroyuki Kumazoe, Masahiro Mitsuoka, Yoshito Akagi
OBJECTIVES: This study compared the prediction of postoperative exercise capacity by employing lung perfusion scintigraphy images obtained with single photon emission computed tomography together with computed tomography (SPECT/CT) versus the common method of counting subsegments (SC method). METHODS: In 18 patients scheduled for lobectomy, predicted postoperative maximum oxygen uptake per kilogram body weight ([Formula: see text]) was calculated by the SPECT/CT and SC methods...
September 2016: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27234509/evaluation-of-pulmonary-perfusion-by-spect-imaging-using-an-endothelial-cell-tracer-in-supine-humans-and-dogs
#11
Xavier Levac, François Harel, Vincent Finnerty, Quang T Nguyen, Myriam Letourneau, Sophie Marcil, Alain Fournier, Jocelyn Dupuis
BACKGROUND: Pulmonary perfusion is not spatially homogeneously distributed, and its variations could be of diagnostic value in lung vascular disease. PulmoBind is a ligand of the adrenomedullin receptor densely expressed in endothelial cells of lung capillaries. The aim of this study was to evaluate spatial distribution of human lung perfusion by using this novel molecular tracer of the pulmonary vascular endothelium. METHODS: Normal humans (n = 19) enrolled into the PulmoBind phase I trial were studied (Clinicaltrials...
December 2016: EJNMMI Research
https://www.readbyqxmd.com/read/27132077/should-we-include-spect-lung-perfusion-in-radiotherapy-treatment-plans-of-thoracic-targets-evidences-from-the-literature
#12
REVIEW
Berardino De Bari, Letizia Deantonio, Jean Bourhis, John O Prior, Mahmut Ozsahin
PURPOSE: To report the available data about the potential impact of integrating lung perfusion SPECT/CT in treatment plans optimization for the irradiation of thoracic targets. MATERIALS AND METHODS: We searched in the PubMed and Scopus databases, English-written articles published from 2000 to June 2015 dealing with the integration of perfusion SPECT/CT in radiotherapy. RESULTS: We found and analyzed 16 research articles (10 dosimetric, 6 clinical) for a total of 578 patients...
June 2016: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/27103651/hyperoxia-and-hypergravity-are-independent-risk-factors-of-atelectasis-in-healthy-sitting-humans-a-pulmonary-ultrasound-and-spect-ct-study
#13
C Dussault, E Gontier, C Verret, M Soret, A Boussuges, G Hedenstierna, S Montmerle-Borgdorff
Aeroatelectasis has developed in aircrew flying routine peacetime flights on the latest generation high-performance aircraft, when undergoing excessive oxygen supply. To single out the effects of hyperoxia and hypergravity on lung tissue compression, and on ventilation and perfusion, eight subjects were studied before and after 1 h 15 min exposure to +1 to +3.5 Gz in a human centrifuge. They performed the protocol three times, breathing air, 44.5% O2, or 100% O2 and underwent functional and topographical imaging of the whole lung by ultrasound and single-photon emission computed tomography combined with computed tomography (SPECT/CT)...
July 1, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27081214/aerosol-delivery-of-sirna-to-the-lungs-part-1-rationale-for-gene-delivery-systems
#14
Susanne R Youngren-Ortiz, Nishant S Gandhi, Laura España-Serrano, Mahavir B Chougule
This article reviews the pulmonary route of administration, aerosol delivery devices, characterization of pulmonary drug delivery systems, and discusses the rationale for inhaled delivery of siRNA. Diseases with known protein malfunctions may be mitigated through the use of siRNA therapeutics. The inhalation route of administration provides local delivery of siRNA therapeutics for the treatment of various pulmonary diseases, however barriers to pulmonary delivery and intracellular delivery of siRNA exists. siRNA loaded nanocarriers can be used to overcome the barriers associated with the pulmonary route, such as anatomical barriers, mucociliary clearance, and alveolar macrophage clearance...
February 28, 2016: Kona: Powder Science and Technology in Japan
https://www.readbyqxmd.com/read/27033892/biomarkers-for-radiation-pneumonitis-using-noninvasive-molecular-imaging
#15
Meetha Medhora, Steven Haworth, Yu Liu, Jayashree Narayanan, Feng Gao, Ming Zhao, Said Audi, Elizabeth R Jacobs, Brian L Fish, Anne V Clough
UNLABELLED: Our goal is to develop minimally invasive biomarkers for predicting radiation-induced lung injury before symptoms develop. Currently, there are no biomarkers that can predict radiation pneumonitis. Radiation damage to the whole lung is a serious risk in nuclear accidents or in radiologic terrorism. Our previous studies have shown that a single dose of 15 Gy of x-rays to the thorax causes severe pneumonitis in rats by 6-8 wk. We have also developed a mitigator for radiation pneumonitis and fibrosis that can be started as late as 5 wk after radiation...
August 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/26838945/veteran-player-tips-the-scale-v-q-spect-ct-proves-decisive-in-blunt-chest-trauma-case-report-and-brief-literature-review
#16
Ewa Witkowska-Patena, Andrzej Mazurek, Mirosław Dziuk
A 29-year-old patient after blunt chest trauma with right lung atelectasis and pulmonary empyema was referred for lung ventilation and perfusion scintigraphy before right-sided pneumonectomy. Radionuclide imaging revealed severely reduced perfusion and lack of ventilation in the collapsed right lung. Additionally, it showed a matching lobar perfusion-ventilation defect in the lower left lobe, which, apart from consolidation area in posterior basal segment, appeared normal in computed tomography. A normal perfusion and ventilation pattern was observed in the upper left lobe...
2016: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/26838481/ventilation-perfusion-spect-lung-scintigraphy-and-computed-tomography-pulmonary-angiography-in-patients-with-clinical-suspicion-of-pulmonary-embolism
#17
S Ibáñez-Bravo, I Banzo, R Quirce, I Martínez-Rodríguez, J Jiménez-Bonilla, N Martínez-Amador, J A Parra, J González-Macías, J M Carril
UNLABELLED: The aim was to compare ventilation/perfusion SPECT lung scintigraphy (V/Q-SPECT) and computed tomography pulmonary angiography (CTPA) in patients with suspicion of pulmonary embolism (PE). MATERIAL AND METHODS: This prospectively designed study included 53 patients with intermediate or high clinical probability of PE. A V/Q-SPECT and CTPA was performed on all patients. The V/Q-SPECT was interpreted according to the European Association of Nuclear Medicine and Molecular Imaging (EANMMI) guidelines...
July 2016: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/26814473/-mri-methods-for-pulmonary-ventilation-and-perfusion-imaging
#18
G Sommer, G Bauman
CLINICAL/METHODICAL ISSUE: Separate assessment of respiratory mechanics, gas exchange and pulmonary circulation is essential for the diagnosis and therapy of pulmonary diseases. Due to the global character of the information obtained clinical lung function tests are often not sufficiently specific in the differential diagnosis or have a limited sensitivity in the detection of early pathological changes. STANDARD RADIOLOGICAL METHODS: The standard procedures of pulmonary imaging are computed tomography (CT) for depiction of the morphology as well as perfusion/ventilation scintigraphy and single photon emission computed tomography (SPECT) for functional assessment...
February 2016: Der Radiologe
https://www.readbyqxmd.com/read/26781157/chronic-thromboembolic-pulmonary-hypertension-comparison-of-dual-energy-computed-tomography-and-single-photon-emission-computed-tomography-in-canines
#19
COMPARATIVE STUDY
Chun Xiang Tang, Gui Fen Yang, U Joseph Schoepf, Zong Hong Han, Li Qi, Yan E Zhao, Jiang Wu, Chang Sheng Zhou, Hong Zhu, Andrew C Stubenrauch, Stefanie Mangold, Long Jiang Zhang, Guang Ming Lu
PURPOSE: To compare diagnostic accuracy between dual-energy CT lung perfused blood volume (Lung PBV) imaging and single photon emission computed tomography (SPECT) in detecting chronic thromboembolic pulmonary hypertension (CTEPH) with histopathological results as reference standard in a canine model. MATERIALS AND METHODS: Eighteen CTEPH canines were included into this experimental study. All procedures including paracentesis, embolization, scanning, pressure measurement and feeding medicine were repeated each two weeks, until systolic/diastolic pressure in canines was ≥ 30/15 mm Hg or mean pulmonary artery pressure ≥ 20 mm Hg, and then sacrificed for histopathology examination...
February 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/26644008/quantification-of-nonuniform-distribution-of-hemi-lung-perfusion-in-chronic-obstructive-pulmonary-disease
#20
Osamu Mitomo
Nonuniform distribution (NUD) of perfusion on single photon emission computed tomography (SPECT) is caused by impaired perfusion-related fluctuations of the functional volume (FFV). It was determined if digital analysis of NUD in each hemi-lung damaged by chronic obstructive pulmonary disease (COPD) could improve the whole lung impairment assessment. We examined 665 subjects and 8 controls by SPECT. The basic whole lung SPECT volume was defined at 10% of maximum whole lung count cutoff threshold (T h). For the whole lung and each hemi-lung, the 10% T h width volume, FFV rate, and misfit from the control were calculated at every T h width number (n) from 1 to 9 for every additional 10% T h from 10 to 100%...
January 2016: Annals of Nuclear Medicine
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