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https://www.readbyqxmd.com/read/28294270/ultra-weak-photon-emission-in-healthy-subjects-and-patients-with-type-2-diabetes-evidence-for-a-non-invasive-diagnostic-tool
#1
Meina Yang, Wenyu Ding, Yanli Liu, Hua Fan, Rajendra P Bajpai, Jialei Fu, Jingxiang Pang, Xiaolei Zhao, Jinxiang Han
BACKGROUND: Spontaneous ultra-weak photon emission (UPE) is a common phenomenon in biological systems and has been linked to pathological states. Researchers have always considered ultra-weak photon emission a potential non-invasive diagnostic tool, but its application in the medical field is stagnant due to the lack of relevant data for pathological states. METHODS: Ultra-weak photon signals from five body sites (forehead, neck, heart, stomach, and navel) in fifty patients with type 2 diabetes and sixty age-matched healthy subjects were measured using a moveable whole-body biophoton detection system...
March 15, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/28285197/graphene-oxide-functionalized-long-period-grating-for-ultrasensitive-label-free-immunosensing
#2
Chen Liu, Qi Cai, Baojian Xu, Weidong Zhu, Lin Zhang, Jianlong Zhao, Xianfeng Chen
We explore graphene oxide (GO) nanosheets functionalized dual-peak long period grating (dLPG) based biosensor for ultrasensitive label-free antibody-antigen immunosensing. The GO linking layer provides a remarkable analytical platform for bioaffinity binding interface due to its favorable combination of exceptionally high surface-to-volume ratio and excellent optical and biochemical properties. A new GO deposition technique based on chemical-bonding in conjunction with physical-adsorption was proposed to offer the advantages of a strong bonding between GO and fiber device surface and a homogeneous GO overlay with desirable stability, repeatability and durability...
March 9, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28278290/exosomes-are-released-by-bystander-cells-exposed-to-radiation-induced-biophoton-signals-reconciling-the-mechanisms-mediating-the-bystander-effect
#3
Michelle Le, Cristian Fernandez-Palomo, Fiona E McNeill, Colin B Seymour, Andrew J Rainbow, Carmel E Mothersill
OBJECTIVE: The objective of our study was to explore a possible molecular mechanism by which ultraviolet (UV) biophotons could elicit bystander responses in reporter cells and resolve the problem of seemingly mutually exclusive mechanisms of a physical UV signal & a soluble factor-mediated bystander signal. METHODS: The human colon carcinoma cell line, HCT116 p53 +/+, was directly irradiated with 0.5 Gy tritium beta particles to induce ultraviolet biophoton emission...
2017: PloS One
https://www.readbyqxmd.com/read/28276967/near-infrared-biophotonics-based-nanodrug-release-systems-and-their-potential-application-for-neuro-disorders
#4
Vidya Sagar, Madhavan Nair
Near-infrared ray (NIR)-responsive 'smart' nanoagents allow spatial and temporal control over the drug delivery process, noninvasively, without affecting healthy tissues and therefore they possess high potential for on-demand, targeted drug/gene delivery. Various NIR-responsive drug/gene delivery techniques are under investigation for peripheral disorders (especially for cancer). Nonetheless, their potential not been extensively examined for brain biomedical application. Areas covered: This review focuses on NIR-responsive characteristics of different NIR-nanobiophotonics-based nanoagents and associated drug delivery strategies...
February 28, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28253906/molecular-imaging-of-nestin-in-neuroinflammatory-conditions-reveals-marked-signal-induction-in-activated-microglia
#5
Senthil Krishnasamy, Yuan-Cheng Weng, Sai Sampath Thammisetty, Daniel Phaneuf, Melanie Lalancette-Hebert, Jasna Kriz
BACKGROUND: Nestin is a known marker of neuronal progenitor cells in the adult brain. Following neuro- and gliogenesis, nestin is replaced by cell type-specific intermediate filaments, e.g., neurofilaments for panneuronal expression and glial fibrillary acidic protein as a specific marker of mature astrocytes. While previous work have been mostly focused on the neuronal fate of nestin-positive progenitors, in the present study, we sought to investigate in real time how nestin signals and cellular expression patterns are controlled in the context of neuroinflammatory challenge and ischemic brain injury...
March 3, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28215331/a-user-s-guide-for-characterizing-plasma-membrane-subdomains-in-living-cells-by-spot-variation-fluorescence-correlation-spectroscopy
#6
S Mailfert, Y Hamon, N Bertaux, H-T He, D Marguet
Due to the intrinsic molecular Brownian agitation within plasma membrane and the vast diversity of membrane components, it is expected that the plasma membrane organization is highly heterogeneous with the formation of local complex multicomponent assemblies of lipids and proteins on different time scales. Still, deciphering this lateral organization on living cells and on the appropriate length and temporal scales has been challenging but is crucial to advance our knowledge on the biological function of the plasma membrane...
2017: Methods in Cell Biology
https://www.readbyqxmd.com/read/28098964/2017-one-decade-of-journal-of-biophotonics
#7
EDITORIAL
Jürgen Popp
No abstract text is available yet for this article.
January 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28059178/nodeless-hollow-core-fiber-for-the-visible-spectral-range
#8
Shou-Fei Gao, Ying-Ying Wang, Xiao-Lu Liu, Chang Hong, Shuai Gu, Pu Wang
We report on a hollow-core fiber (HCF) whose fundamental transmission band covers almost the whole visible spectral window, starting at 440 nm. This HCF, in the form of a nodeless structure (NL-HCF), exhibits unprecedented optical performance in terms of low transmission attenuation of 80 dB/km at 532 nm, a broad transmission bandwidth from 440 to 1200 nm, a low bending loss of 0.2 dB/m at 532 nm under 8 cm bending radius, and single-mode profile. When launched to high-power picosecond laser systems at 532 nm, the fiber, exposed to ambient air, could easily deliver an 80 ps, 58 MHz, 32 W average power laser pulse with no damage and a 20 ps, 1 kHz high-energy laser pulse with a damage threshold in excess of 144 μJ at a fiber output...
January 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28048672/tu-c-horizons-01-the-expanding-horizons-travel-grant-program-eposters-and-discussion
#9
J Siewerdsen, R Jeraj
The Expanding Horizons travel grant program provides opportunity for students and trainees to broaden the scope of scientific meetings they attend and gain insight from research outside traditional domains of medical physics. Through participation in such conferences, early-career researchers are introduced to new topics with relevance to medical physics research as a means to expand the scientific horizons of our discipline. This year, 21 Expanding Horizons travel grants were awarded, granting travel to 17 conferences, including: Radiomics, the World Molecular Imaging Society (WMIS), the 3D Printing Conference and Expo, the GPU Technology Conference, the SIAM Imaging Science Conference, the Human Brain Mapping Conference, the OSA Conference on Clinical and Translational Biophotonics, the Society for Neuroscience, the AACR Conference on Tumor Microenvironment, and the Conference on Knowledge Discovery and Data Mining...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28038335/airborne-soil-particulates-as-vehicles-for-salmonella-contamination-of-tomatoes
#10
Govindaraj Dev Kumar, Robert C Williams, Hamzeh M Al Qublan, Nammalwar Sriranganathan, Renee R Boyer, Joseph D Eifert
The presence of dust is ubiquitous in the produce growing environment and its deposition on edible crops could occur. The potential of wind-distributed soil particulate to serve as a vehicle for S. Newport transfer to tomato blossoms and consequently, to fruits, was explored. Blossoms were challenged with previously autoclaved soil containing S. Newport (9.39log CFU/g) by brushing and airborne transfer. One hundred percent of blossoms brushed with S. Newport-contaminated soil tested positive for presence of the pathogen one week after contact (P<0...
February 21, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/27999859/special-section-guest-editorial-translational-biophotonics
#11
Gabriela Apiou-Sbirlea, Conor L Evans, Kristen M Kelly, Bruce J Tromberg
No abstract text is available yet for this article.
December 1, 2016: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/27958465/simulation-and-experimental-verification-for-imaging-of-gray-scale-objects-through-scattering-layers
#12
Huijuan Li, Tengfei Wu, Jietao Liu, Changmei Gong, Xiaopeng Shao
We analyze the imaging of gray-scale objects through highly scattering layers. The theoretical investigation with numerical simulations shows that the contrast of the speckle autocorrelations varies regularly with the change of the gray scale of the object. Therefore, gray information is well contained in the autocorrelations of the speckle patterns, and gray-scale objects are able to be exacted from these autocorrelations via speckle correlation technology. Combined with phase retrieval via the generalized approximate message passing algorithm, recovery of the objects is realized and accurate gray-scale reconstruction is demonstrated via numerical simulations...
December 1, 2016: Applied Optics
https://www.readbyqxmd.com/read/27943650/modern-trends-in-biophotonics-for-clinical-diagnosis-and-therapy-to-solve-unmet-clinical-needs
#13
Christoph Krafft
This contribution covers recent original research papers in the biophotonics field. The content is organized into main techniques such as multiphoton microscopy, Raman spectroscopy, infrared spectroscopy, optical coherence tomography and photoacoustic tomography, and their applications in the context of fluid, cell, tissue and skin diagnostics. Special attention is paid to vascular and blood flow diagnostics, photothermal and photodynamic therapy, tissue therapy, cell characterization, and biosensors for biomarker detection...
December 2016: Journal of Biophotonics
https://www.readbyqxmd.com/read/27819310/possible-existence-of-optical-communication-channels-in-the-brain
#14
Sourabh Kumar, Kristine Boone, Jack Tuszyński, Paul Barclay, Christoph Simon
Given that many fundamental questions in neuroscience are still open, it seems pertinent to explore whether the brain might use other physical modalities than the ones that have been discovered so far. In particular it is well established that neurons can emit photons, which prompts the question whether these biophotons could serve as signals between neurons, in addition to the well-known electro-chemical signals. For such communication to be targeted, the photons would need to travel in waveguides. Here we show, based on detailed theoretical modeling, that myelinated axons could serve as photonic waveguides, taking into account realistic optical imperfections...
November 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27787981/moth-eye-inspired-biophotonic-surfaces-with-antireflective-and-hydrophobic-characteristics
#15
Wen-Kai Kuo, Jyun-Jheng Hsu, Chih-Kai Nien, Hsin Her Yu
In nature, in order to prevent attention from predators, the eyes of night-flying moths have evolutionarily developed an antireflective ability. The surfaces of their eyes are covered with a layer of a sub-wavelength structure that eliminates reflections of visible light. This layer allows the eyes of moths to escape detection in darkness, without reflections that could reveal the position of the moths to potential predators. In this study, we proposed a novel procedure for manufacturing a non-close-packed polystyrene (PS) nanosphere monolayer by combining the Langmuir-Blodgett (LB) deposition technique and oxygen plasma treatment...
November 23, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27778012/dual-band-moir%C3%A3-metasurface-patches-for-multifunctional-biomedical-applications
#16
Zilong Wu, Glen Kelp, Maruthi Nagavalli Yogeesh, Wei Li, Kyle M McNicholas, Andrew Briggs, Bharath Bangalore Rajeeva, Deji Akinwande, Seth R Bank, Gennady Shvets, Yuebing Zheng
There has been strong interest in developing multi-band plasmonic metasurfaces for multiple optical functions on single platforms. Herein, we developed Au moiré metasurface patches (AMMP), which leverage the tunable multi-band responses of Au moiré metasurfaces and the additional field enhancements of the metal-insulator-metal configuration to achieve dual-band plasmon resonance modes in near-infrared and mid-infrared regimes with high field enhancement. Furthermore, we demonstrate the multifunctional applications of AMMP, including surface-enhanced infrared spectroscopy, optical capture and patterning of bacteria, and photothermal denaturation of proteins...
October 25, 2016: Nanoscale
https://www.readbyqxmd.com/read/27735017/investigation-on-dynamics-of-red-blood-cells-through-their-behavior-as-biophotonic-lenses
#17
Pasquale Memmolo, Francesco Merola, Lisa Miccio, Martina Mugnano, Pietro Ferraro
No abstract text is available yet for this article.
December 1, 2016: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/27668148/regioselective-localization-and-tracking-of-biomolecules-on-single-gold-nanoparticles
#18
Bharath Bangalore Rajeeva, Derek S Hernandez, Mingsong Wang, Evan Perillo, Linhan Lin, Leonardo Scarabelli, Bharadwaj Pingali, Luis M Liz-Marzán, Andrew K Dunn, Jason B Shear, Yuebing Zheng
Selective localization of biomolecules at the hot spots of a plasmonic nanoparticle is an attractive strategy to exploit the light-matter interaction due to the high field concentration. Current approaches for hot spot targeting are time-consuming and involve prior knowledge of the hot spots. Multiphoton plasmonic lithography is employed to rapidly immobilize bovine serum albumin (BSA) hydrogel at the hot spot tips of a single gold nanotriangle (AuNT). Regioselectivity and quantity control by manipulating the polarization and intensity of the incident laser are also established...
November 2015: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/27661870/broadband-stimulated-raman-scattering-spectroscopy-by-a-photonic-time-stretcher
#19
Francesco Saltarelli, Vikas Kumar, Daniele Viola, Francesco Crisafi, Fabrizio Preda, Giulio Cerullo, Dario Polli
Stimulated Raman scattering spectroscopy is a powerful technique for label-free molecular identification, but its broadband implementation is technically challenging. We introduce and experimentally demonstrate a novel approach based on photonic time stretch. The broadband femtosecond Stokes pulse, after interacting with the sample, is stretched by a telecom fiber to ≈15ns, mapping its spectrum in time. The signal is sampled through a fast analog-to-digital converter, providing single-shot spectra at 80-kHz rate...
September 19, 2016: Optics Express
https://www.readbyqxmd.com/read/27650872/infectivity-of-attenuated-poxvirus-vaccine-vectors-and-immunogenicity-of-a-raccoonpox-vectored-rabies-vaccine-in-the-brazilian-free-tailed-bat-tadarida-brasiliensis
#20
Ben R Stading, Jorge E Osorio, Andres Velasco-Villa, Michael Smotherman, Brock Kingstad-Bakke, Tonie E Rocke
Bats (Order Chiroptera) are an abundant group of mammals with tremendous ecological value as insectivores and plant dispersers, but their role as reservoirs of zoonotic diseases has received more attention in the last decade. With the goal of managing disease in free-ranging bats, we tested modified vaccinia Ankara (MVA) and raccoon poxvirus (RCN) as potential vaccine vectors in the Brazilian Free-tailed bat (Tadarida brasiliensis), using biophotonic in vivo imaging and immunogenicity studies. Animals were administered recombinant poxviral vectors expressing the luciferase gene (MVA-luc, RCN-luc) through oronasal (ON) or intramuscular (IM) routes and subsequently monitored for bioluminescent signal indicative of viral infection...
October 17, 2016: Vaccine
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