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Hua Shi, Qingming Luo
Biophotonics is a highly interdisciplinary field where physicists, chemists, biologists, physicians and engineers work together to solve the problems appearing in biology and medicine. In China, the Biophotonics discipline is often referred to as Biomedical Photonics, under the first-level disciplines Biomedical Engineering or Optical Engineering, and was initiated in the late 1990s. Over the past 20 years, biophotonics research in China expanded extraordinarily and has reached the frontiers of the world-level sciences...
December 2017: Journal of Biophotonics
Nirosha J Murugan, Nicolas Rouleau, Lukasz M Karbowski, Michael A Persinger
Early detection is a critically important factor when successfully diagnosing and treating cancer. Whereas contemporary molecular techniques are capable of identifying biomarkers associated with cancer, surgical interventions are required to biopsy tissue. The common imaging alternative, positron-emission tomography (PET), involves the use of nuclear material which poses some risks. Novel, non-invasive techniques to assess the degree to which tissues express malignant properties are now needed. Recent developments in biophoton research have made it possible to discriminate cancerous cells from normal cells both in vitro and in vivo...
March 2018: Biochemistry and Biophysics Reports
Hui Li, Lei Xu, Guanying Chen
The ability to synthesize upconversion nanocrystals (UCNCs) with tailored upconversion luminescence and controlled size is of great importance for biophotonic applications. However, until now, limited success has been met to prepare bright, ultrasmall, and monodispersed β-NaYF₄:Yb3+/Er3+ UCNCs. In this work, we report on a synthetic method to produce monodisperse hexagonal NaYF₄:Yb3+/Er3+ nanocrystals of ultrasmall size (5.4 nm) through a precise control of the reaction temperature and the ratio of Na⁺/Ln3+/F-...
December 1, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Andreas Nikolis, Stéphane Fauverghe, Giovanni Scapagnini, Dimitrios Sotiriadis, George Kontochristopoulos, Athanasios Petridis, Dimitrios Rigopoulos, Clio Dessinioti, Konstantinos Kalokasidis, Christina Antoniou
A variety of laser/light-based devices have been reported to be effective for the treatment of acne, yet no long-term data on efficacy and safety have been published. A first 12-week clinical trial ("Main trial") recently demonstrated that the KLOX BioPhotonic System, an LED blue light device using photo-converter chromophores, can significantly improve moderate and severe facial acne vulgaris with an excellent safety profile. This Extension trial followed the Main trial, using the same BioPhotonic System, with the same dose and instructions for use, on patients having already completed treatment in the Main trial...
November 20, 2017: International Journal of Dermatology
A T Press, M J Butans, T P Haider, C Weber, S Neugebauer, M Kiehntopf, U S Schubert, M G Clemens, M Bauer, A Kortgen
Simultaneous assessment of excretory liver and kidney function is still an unmet need in experimental stress models as well as in critical care. The aim of the study was to characterize two polymethine-dyes potentially suitable for this purpose in vivo. Plasma disappearance rate and elimination measurements of simultaneously injected fluorescent dyes DY-780 (hepato-biliary elimination) and DY-654(renal elimination) were conducted using catheter techniques and intravital microscopy in animals subjected to different organ injuries, i...
November 13, 2017: Scientific Reports
Tobias Tiess, Martin Becker, Manfred Rothhardt, Hartmut Bartelt, Matthias Jäger
We present a fiber-integrated laser enabling independent tuning of two emission wavelengths with a synchronized pulsed emission. The discrete tuning concept comprises a theta cavity fiber laser (TCFL), a fiber Bragg grating (FBG) array as a versatile spectral filter, facilitating tailored tuning ranges, and optical gating to control the emission spectrum. A novel electrical driving scheme uniquely enables independently tunable multi-wavelength emission from a single laser oscillator. Tunable dual-wavelength emission is experimentally investigated with a ytterbium (Yb)-doped TCFL using an FBG array with 11 gratings...
October 30, 2017: Optics Express
Radwanul H Siddique, Yidenekachew J Donie, Guillaume Gomard, Sisir Yalamanchili, Tsvetelina Merdzhanova, Uli Lemmer, Hendrik Hölscher
The wings of the black butterfly, Pachliopta aristolochiae, are covered by micro- and nanostructured scales that harvest sunlight over a wide spectral and angular range. Considering that these properties are particularly attractive for photovoltaic applications, we analyze the contribution of these micro- and nanostructures, focusing on the structural disorder observed in the wing scales. In addition to microspectroscopy experiments, we conduct three-dimensional optical simulations of the exact scale structure...
October 2017: Science Advances
Liana Lucchetti, Tommaso P Fraccia, Fabrizio Ciciulla, Francesco Simoni, Tommaso Bellini
We report the experimental evidence of nonlinear optical response in DNA lyotropic nematic liquid crystals. Pump-probe experiments indicate that the non-linearity is remarkably large. Quantitative assessment of the non-linear optical coefficient by transient optical grating demonstrates that the response is of the same order of the well-known Giant Optical Nonlinearity (GON) of thermotropic nematics. These results represent a further incentive to the current investigation of potential applications of DNA in biophotonics...
October 16, 2017: Optics Express
Pei-Han Liu, Pawel L Urban
The temporal effects of luciferase reaction luminescence have only been discussed in the context of light intensity (flash vs. glow). However, alterations in the color of the light emitted over the course of the luciferase reaction have not been reported. Here, we show a temporal change in the light color emitted during the reaction catalyzed by unmodified firefly luciferase when concentrations of one of the substrates, adenosine triphosphate (ATP), are gradually increased. The temporal color change from green to red occurs within the first few minutes of the luciferase reaction when an ATP-containing solution is either added or synthesized in situ with the aid of an autocatalytic reaction occurring simultaneously...
October 13, 2017: Analytical Biochemistry
Jürgen Popp, Dennis Matthews, Alfredo Martinez-Coll, Thomas Mayerhöfer, Brian C Wilson
We first discuss the main obstacles for clinical translation of biophotonics technologies, in particular, the different valleys of death, after which we present different examples of ways to bridge these gaps, remove the obstacles, and promote clinical translation.
October 2017: Journal of Biomedical Optics
Susan M Smith, George R Flentke
Prenatal alcohol exposure (PAE) remains a leading preventable cause of structural birth defects and permanent neurodevelopmental disability. The chick (Gallus gallus domesticus) is a powerful embryological research model and was possibly the first (Fere, 1895) in which alcohol's teratogenicity was demonstrated. Pharmacologically relevant alcohol exposures in the range of 20-70 mM (20-80 mg/egg) disrupt chick embryo growth, morphogenesis, and behavior, and the resulting phenotypes strongly parallel those of mammalian models...
October 12, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
Martin Leahy, Tia Keyes, Valery Tuchin, Alexander Priezzhev
This guest editorial introduces the special section on Advanced Laser Technologies for Biophotonics.
September 27, 2017: Journal of Biomedical Optics
Thibaud Mathis, Stephane Vignot, Cecila Leal, Jean-Pierre Caujolle, Celia Maschi, Martine Mauget-Faÿsse, Laurent Kodjikian, Stéphanie Baillif, Joel Herault, Juliette Thariat
Anomalous visual perceptions have been reported in various diseases of the retina and visual pathways or can be experienced under specific conditions in healthy individuals. Phosphenes are perceptions of light in the absence of ambient light, occurring independently of the physiological and classical photonic stimulation of the retina. They are a frequent symptom in patients irradiated in the region of the central nervous system (CNS), head and neck and the eyes. Phosphenes have historically been attributed to complex physical phenomena such as Cherenkov radiation...
September 8, 2017: Oncotarget
Mengyu Jia, Jingying Jiang, Wenjuan Ma, Chenxi Li, Shuang Wang, Huijuan Zhao, Feng Gao
Image reconstruction in the most model-based biophotonic imaging modalities essentially poses an ill-posed nonlinear inverse problem, which has been effectively tackled in the diffusion-approximation-satisfied scenarios such as diffuse optical tomography. Nevertheless, a nonlinear implementation in high-resolution laminar optical tomography (LOT) is normally computationally-costly due to its strong dependency on a dense source-detector configuration and a physically-rigorous photon-transport model. To circumvent the adversity, we herein propose a practical nonlinear LOT approach to the absorption reconstruction...
September 1, 2017: Biomedical Optics Express
Minhee Kang, Myeong-Su Ahn, Youngseop Lee, Ki-Hun Jeong
Unlike monometallic materials, bimetallic plasmonic materials offer extensive benefits such as broadband tuning capability or high environmental stability. Here we report a broad range tuning of plasmon resonance of alloyed nanoislands by using solid-state dewetting of gold and silver bilayer thin films. Thermal dewetting after successive thermal evaporation of thin metal double-layer films readily forms AuAg-alloyed nanoislands with a precise composition ratio. The complete miscibility of alloyed nanoislands results in programmable tuning of plasmon resonance wavelength in a broadband visible range...
October 12, 2017: ACS Applied Materials & Interfaces
Melanie L Sutton-McDowall, Martin Gosnell, Ayad G Anwer, Melissa White, Malcolm Purdey, Andrew D Abell, Ewa M Goldys, Jeremy G Thompson
STUDY QUESTION: Can we separate embryos cultured under either 7% or 20% oxygen atmospheres by measuring their metabolic heterogeneity? SUMMARY ANSWER: Metabolic heterogeneity and changes in metabolic profiles in morula exposed to two different oxygen concentrations were not detectable using traditional fluorophore and two-channel autofluorescence but were detectable using hyperspectral microscopy. WHAT IS KNOWN ALREADY: Increased genetic and morphological blastomere heterogeneity is associated with compromised developmental competence of embryos and currently forms the basis for embryo scoring within the clinic...
October 1, 2017: Human Reproduction
Velu Arasu, Sreekantha Reddy Dugasani, Mallikarjuna Reddy Kesama, Ho Kyoon Chung, Sung Ha Park
To be useful in optoelectronic devices and sensors, a platform comprising stable fluorescence materials is essential. Here we constructed quantum dots (QDs) embedded DNA thin films which aims for stable fluorescence through the stabilization of QDs in the high aspect ratio salmon DNA (SDNA) matrix. Also for maximum luminescence, different concentration and configurations of core- and core/alloy/shell-type QDs were embedded within SDNA. The QD-SDNA thin films were constructed by drop-casting and investigated their optoelectronic properties...
September 14, 2017: Scientific Reports
Pascual Muñoz, Gloria Micó, Luis A Bru, Daniel Pastor, Daniel Pérez, José David Doménech, Juan Fernández, Rocío Baños, Bernardo Gargallo, Rubén Alemany, Ana M Sánchez, Josep M Cirera, Roser Mas, Carlos Domínguez
Silicon nitride photonics is on the rise owing to the broadband nature of the material, allowing applications of biophotonics, tele/datacom, optical signal processing and sensing, from visible, through near to mid-infrared wavelengths. In this paper, a review of the state of the art of silicon nitride strip waveguide platforms is provided, alongside the experimental results on the development of a versatile 300 nm guiding film height silicon nitride platform.
September 12, 2017: Sensors
Ling Huang, Yang Zhao, He Zhang, Kai Huang, Jinyi Yang, Gang Han
A strategy to expand anti-Stokes shifting from the far-red to deep-blue region in metal-free triplet-triplet annihilation upconversion (TTA-UC) is presented. The method is demonstrated by in vivo titration of the photorelease of an anticancer prodrug. This new TTA system has robust brightness and the longest anti-Stokes shift of any reported TTA system. TTA core-shell-structured prodrug delivery capsules that benefit from these properties were developed; they can operate with low-power density far-red light-emitting diode light...
September 5, 2017: Angewandte Chemie
Yuchao Li, Xiaoshuai Liu, Xianguang Yang, Hongxiang Lei, Yao Zhang, Baojun Li
Upconversion fluorescence has triggered extensive efforts in the past decade because of its superior physicochemical features and great potential in biomedical and biophotonic studies. However, practical applications of upconversion fluorescence are often hindered by its relatively low luminescence efficiency (<1%). Here, we employ a living yeast or human cell as a natural bio-microlens to enhance the upconversion fluorescence. The natural bio-microlens, which was stably trapped on a fiber probe, could concentrate the excitation light into a subwavelength region so that the upconversion fluorescence of core-shell NaYF4:Yb(3+)/Tm(3+) nanoparticles was enhanced by 2 orders of magnitude...
September 7, 2017: ACS Nano
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