keyword
https://read.qxmd.com/read/38490460/efficient-production-of-r-2-4-hydroxyphenoxy-propionic-acid-by-beauveria-bassiana-using-biofilm-based-two-stage-fermentation
#21
JOURNAL ARTICLE
Shuping Zou, Yizhi Ma, Wei Ding, Yongkang Jiang, Xiaomin Chen, Juan Chen, Hailing Gao, Yaping Xue, Yuguo Zheng
In this work, a novel biofilm-based fermentation of Beauveria bassiana was employed to convert R-2- phenoxypropionic acid (R-PPA) to R-2-(4-hydroxyphenoxy) propionic acid (R-HPPA). The biofilm culture model of Beauveria bassiana produced a significantly higher R-HPPA titer than the traditional submerged fermentation method. Mannitol dosage, tryptone dosage, and initial pH were the factors that played a significant role in biofilm formation and R-HPPA synthesis. Under the optimal conditions, the maximum R-HPPA titer and productivity approached 22...
March 13, 2024: Bioresource Technology
https://read.qxmd.com/read/38490425/development-of-3d-printable-stabilized-earth-based-construction-materials-using-excavated-soil-evaluation-of-fresh-and-hardened-properties
#22
JOURNAL ARTICLE
Prabhath Ranjan Kumar Soda, Ashutosh Dwivedi, Sahana Cm, Souradeep Gupta
Soil excavated during construction and demolition can be utilized to reduce the demand for natural sand in 3D printed constructions. This research attempts to systematically develop 3D printable stabilized earth-based materials using excavated soil (clay content of 42.5 %) as 25 % and 50 % replacement of natural sand, and examine their compressive strength, water permeable porosity, and moisture sensitivity. The effectiveness of two binder systems - ordinary Portland cement (OPC) and a combination of OPC and ground granulated blast furnace slag (GGBS used to replace 30 % OPC by mass), was investigated...
March 13, 2024: Science of the Total Environment
https://read.qxmd.com/read/38490379/microwave-promoted-graft-copolymerization-of-poly-ethylacrylate-onto-k-carrageenan-for-removal-of-cd-and-ni-from-aqueous-solution
#23
JOURNAL ARTICLE
Mwumvaneza Moses, Eric Mutegoa, Somit K Singh
Microwave promoted graft copolymerization of poly (ethyl acrylate) onto kappa-carrageenan in presence of a redox pair (ascorbic acid and potassium persulfate) led to the formation of a novel copolymer hydrogel, kappa-carrageenan-graft-poly (ethylacrylate). By varying the reaction conditions such as the microwave power, reaction time, concentration of kappa-carrageenan, ascorbic acid and persulfate, copolymers of highest percentage grafting was obtained and characterized by FT-IR, SEM, TGA and XRD. The copolymer was evaluated as an adsorbent for the adsorption of Ni(II) and Cd(II)...
March 13, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38490374/rotor-based-lmage-guided-therapy-of-glioblastoma
#24
JOURNAL ARTICLE
Zhenxing Pan, Yaoxun Zeng, Zhaoyi Ye, Yushan Li, Yakun Wang, Zhenzhen Feng, Ying Bao, Jiongpeng Yuan, Guining Cao, Jiapeng Dong, Wei Long, Yu-Jing Lu, Kun Zhang, Yan He, Xujie Liu
Glioblastoma (GBM), deep in the brain, is more challenging to diagnose and treat than other tumors. Such challenges have blocked the development of high-impact therapeutic approaches that combine reliable diagnosis with targeted therapy. Herein, effective cyanine dyes (IRLy) with the near-infrared two region (NIR-II) adsorption and aggregation-induced emission (AIE) have been developed via an "extended conjugation & molecular rotor" strategy for multimodal imaging and phototherapy of deep orthotopic GBM...
March 13, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38490373/liposome-integrated-hydrogel-hybrids-promising-platforms-for-cancer-therapy-and-tissue-regeneration
#25
JOURNAL ARTICLE
Mehdi Sanati, Saber Amin Yavari
Drug delivery platforms have gracefully emerged as an indispensable component of novel cancer chemotherapy, bestowing targeted drug distribution, elevating therapeutic effects, and reducing the burden of unwanted side effects. In this context, hybrid delivery systems artfully harnessing the virtues of liposomes and hydrogels bring remarkable benefits, especially for localized cancer therapy, including intensified stability, excellent amenability to hydrophobic and hydrophilic medications, controlled liberation behavior, and appropriate mucoadhesion to mucopenetration shift...
March 13, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38490343/caffeic-acid-phenethyl-ester-an-effective-antiviral-agent-against-porcine-reproductive-and-respiratory-syndrome-virus
#26
JOURNAL ARTICLE
Zhanding Cui, Jing Zhang, Jinlong Wang, Jinlong Liu, Pu Sun, Jiaoyang Li, Guoxiu Li, Ying Sun, Juanbin Ying, Kun Li, Zhixun Zhao, Hong Yuan, Xingwen Bai, Xueqing Ma, Pinghua Li, Yuanfang Fu, Huifang Bao, Dong Li, Qiang Zhang, Zaixin Liu, Yimei Cao, Zengjun Lu
Porcine Reproductive and Respiratory Syndrome (PRRS) presents a formidable viral challenge in swine husbandry. Confronting the constraints of existing veterinary pharmaceuticals and vaccines, this investigation centers on Caffeic Acid Phenethyl Ester (CAPE) as a prospective clinical suppressant for the Porcine Reproductive and Respiratory Syndrome Virus (PRRSV). The study adopts an integrated methodology to evaluate CAPE's antiviral attributes. This encompasses a dual-phase analysis of CAPE's interaction with PRRSV, both in vitro and in vivo, and an examination of its influence on viral replication...
March 13, 2024: Antiviral Research
https://read.qxmd.com/read/38490332/evaluation-of-an-enhanced-depression-and-anxiety-screening-with-targeted-pharmacist-intervention
#27
JOURNAL ARTICLE
Shelby Reid, Robert Nichols, Stevie Veach, Eilan Alhersh, Matthew Witry
BACKGROUND: Depression is a significant source of morbidity but often goes undiagnosed. Broader screening is recommended, and pharmacists could contribute. OBJECTIVES: Assess the feasibility of community pharmacy depression and anxiety screening and describe the medication-related problems (MRP) identified, pharmacist interventions, and provider responses for high-risk patients. METHODS: This pilot was conducted between October 2022 and January 2023 at an independently owned community pharmacy in the Midwest U...
March 13, 2024: Journal of the American Pharmacists Association: JAPhA
https://read.qxmd.com/read/38490153/dose-dependent-physiological-effects-of-uv-c-radiation-on-seashore-paspalum
#28
JOURNAL ARTICLE
Qianqian Fan, Paul L Raymer, Bochra Amina Bahri, David Jespersen
Positive effects of ultraviolet-C (UV-C) radiation on plants have been documented in previous literature with a focus on extending shelf life and reducing disease development. However, its effect on plant growth habits has been scarcely explored, especially in turfgrass where a compact shoot growth is a desirable trait. Seashore paspalum (Paspalum vaginatum) is a warm-season perennial turfgrass requiring low fertilizer and pesticide inputs. This project aimed to test the effects of different doses of UV-C radiation on growth and performance of seashore paspalum cv...
March 11, 2024: Plant Physiology and Biochemistry: PPB
https://read.qxmd.com/read/38490043/a-randomized-double-blind-clinical-trial-comparison-of-oclacitinib-with-a-traditional-chinese-herbal-medicine-product-dihuang-guiqin-capsule-in-the-treatment-of-canine-atopic-dermatitis
#29
JOURNAL ARTICLE
Jun-Jie Qin, Hao Zhu, Zhe-Wen Song, Xiao-Jiao Hou, Xiu-Min Wang, Lei Wang, Jian-Xi Li
Canine atopic dermatitis (cAD) is a common chronic inflammatory skin disease, which seriously affects the quality of life for both dogs and their owners. Currently, the common therapeutic drugs in the clinic have disadvantages such as obvious adverse effects and high prices. Traditional Chinese herbal medicine (TCHM) has great potential for the treatment of cAD. The aim of this study is to compare the effects of different doses of the TCHM product (Dihuang Guiqin capsule) and oclacitinib in the treatment of cAD through a randomized, double-blind trial...
March 11, 2024: Research in Veterinary Science
https://read.qxmd.com/read/38490042/liquid-chromatography-coupled-to-tandem-mass-spectrometry-lc-ms-ms-methods-for-the-therapeutic-drug-monitoring-of-cytotoxic-anticancer-drugs-an-update
#30
REVIEW
M Briki, A Murisier, M Guidi, C Seydoux, T Buclin, C Marzolini, F R Girardin, Y Thoma, S Carrara, E Choong, L A Decosterd
In the era of precision medicine, there is increasing evidence that conventional cytotoxic agents may be suitable candidates for therapeutic drug monitoring (TDM)- guided drug dosage adjustments and patient's tailored personalization of non-selective chemotherapies. To that end, many liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) assays have been developed for the quantification of conventional cytotoxic anticancer chemotherapies, that have been comprehensively and critically reviewed...
February 3, 2024: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://read.qxmd.com/read/38489886/effects-of-dietary-supplementation-of-postbiotic-derived-from-bacillus-subtilis-accc-11025-on-growth-performance-meat-yield-meat-quality-excreta-bacteria-and-excreta-ammonia-emission-of-broiler-chicks
#31
JOURNAL ARTICLE
Shan Fang, Xinyan Fan, Suixin Xu, Shenyang Gao, Tieliang Wang, Zeliang Chen, Desheng Li
The primary aim of this study was to explore the impact of dietary supplementation with a postbiotic derived from Bacillus subtilis ACCC 11025 on growth performance, meat yield, meat quality, excreta bacterial populations, and excreta ammonia emissions of broiler chicks. A total of 480 day-old Arbor Acre broiler chicks, initially weighing 52.83 ± 1.38 g, were randomly allocated into 4 distinct groups. Each group was housed in 6 separate cages, each containing 20 birds. The experimental phase spanned 42 d, divided into 2 periods (d 1-21 and d 22-42)...
January 9, 2024: Poultry Science
https://read.qxmd.com/read/38489728/clinical-responses-to-vemurafenib-in-postoperative-recurrence-of-papillary-thyroid-carcinoma-with-esophageal-fistula-a-case-report
#32
JOURNAL ARTICLE
Sicheng He, Wei Lu, Xun Ding, Jun Zhou, Di Liu, Yang Zhu, Fugang Yang, Zanmei Fu
BACKGROUND: While papillary thyroid carcinoma (PTC) generally exhibits a favorable prognosis post-surgery, the poorly differentiated subtype presents elevated rates of postoperative recurrence. Certain aggressive cases demonstrate invasive behavior, compromising adjacent structures and leading to a poor prognosis. This study delineates a unique case of postoperative PTC recurrence, complicated by esophageal fistula, that showed favorable outcomes following brief Vemurafenib treatment...
March 15, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38488523/uncovering-a-novel-mechanism-butyrate-induces-estrogen-receptor-alpha-activation-independent-of-estrogen-stimulation-in-mcf-7-breast-cancer-cells
#33
JOURNAL ARTICLE
Veronica Dayali Gutierrez-Martinez, Alfonso León-Del-Río, Abelardo Camacho-Luis, Victor Manuel Ayala-Garcia, Angélica María Lopez-Rodriguez, Estela Ruiz-Baca, Ivan Meneses-Morales
Butyrate is a promising candidate for an antitumoral drug, as it promotes cancer cell apoptosis and reduces hormone receptor activity, while promoting differentiation and proliferation in normal cells. However, the effects of low-dose butyrate on breast cancer cell cultures are unclear. We explored the impact of sub-therapeutic doses of butyrate on estrogen receptor alpha (ERα) transcriptional activity in MCF-7 cells, using RT-qPCR, Western blot, wound-healing assays, and chromatin immunoprecipitation...
2024: Genetics and Molecular Biology
https://read.qxmd.com/read/38488241/po-2-reporter-composite-hydrogel-macroencapsulation-devices-for-magnetic-resonance-imaging-oxygen-quantification
#34
JOURNAL ARTICLE
Amy E Emerson, Yuka Sugamura, Jad Mazboudi, Tuhfah M Abdallah, Charmayne D Seaton, Azin Ghasemi, Vikram D Kodibagkar, Jessica D Weaver
Hydrogel cell encapsulation devices are a common approach to reduce the need for chronic systemic immunosuppression in allogeneic cell product transplantation. Macroencapsulation approaches are an appealing strategy, as they maximize graft retrievability and cell dosage within a single device; however, macroencapsulation devices face oxygen transport challenges as geometries increase from preclinical to clinical scales. Device design guided by computational approaches can facilitate graft oxygen availability to encapsulated cells in vivo but is limited without accurate measurement of oxygen levels within the transplant site and graft...
March 15, 2024: Journal of Biomedical Materials Research. Part A
https://read.qxmd.com/read/38487986/effect-of-single-oral-coingestion-of-gaba-and-malic-acid-on-postprandial-glp-1-glucose-and-insulin-responses-in-healthy-volunteers-a-randomized-double-blind-placebo-controlled-crossover-study
#35
JOURNAL ARTICLE
Hiroki Noguchi, Takeshi Ikenaga, Shota Ueno, Chieko Kohashi, Yasuhiro Matsumura, Yusuke Kakumoto, Noriyuki Kohda, Hiroshi Hara, Tohru Hira
SCOPE: This study examines whether coingestion of γ-aminobutyric acid (GABA) and malic acid (MA) before meals enhances glucagon-like peptide-1 (GLP-1) secretion, and which affects subsequent insulin and glycemic responses in humans. METHODS AND RESULTS: Initially, a murine enteroendocrine STC-1 cell line is used to verify coadministration of GABA and MA synergistically induces GLP-1 secretion. Next, 22 healthy adults are given water (50 mL) containing 400 mg GABA and 400 mg MA (Test), or only 400 mg citric acid (CA) (Placebo) 20 min before meal tolerance test (MTT)...
March 15, 2024: Molecular Nutrition & Food Research
https://read.qxmd.com/read/38487942/a-physiologically-based-pharmacokinetic-pharmacodynamic-modeling-approach-for-drug-drug-gene-interaction-evaluation-of-s-warfarin-with-fluconazole
#36
JOURNAL ARTICLE
Kuo Geng, Chaozhuang Shen, Xiaohu Wang, Xingwen Wang, Wenxin Shao, Wenhui Wang, Tao Chen, Hua Sun, Haitang Xie
Warfarin is a widely used anticoagulant, and its S-enantiomer has higher potency compared to the R-enantiomer. S-warfarin is mainly metabolized by cytochrome P450 (CYP) 2C9, and its pharmacological target is vitamin K epoxide reductase complex subunit 1 (VKORC1). Both CYP2C9 and VKORC1 have genetic polymorphisms, leading to large variations in the pharmacokinetics (PKs) and pharmacodynamics (PDs) of warfarin in the population. This makes dosage management of warfarin difficult, especially in the case of drug-drug interactions (DDIs)...
March 15, 2024: CPT: Pharmacometrics & Systems Pharmacology
https://read.qxmd.com/read/38487755/should-i-supplement-vitamin-d-in-a-patient-with-sepsis
#37
JOURNAL ARTICLE
Vedran Kovacic
Sepsis is a potentially fatal organ failure produced by the host's immune response to infection. It is critical to identify risk factors associated with a poor prognosis in septic patients in order to develop new therapy options. Vitamin D deficiency (25-hydroxyvitamin cholecalciferol < 20 ng/mL) is common in critical and septic patients. Serum vitamin D concentrations are associated with an increased incidence of mortality in critically ill adult patients. In critically ill patients, vitamin D supplementation (a very high vitamin D 3 or cholecalciferol loading dosage as a single bolus dose ranging from 400,000 to 540,000 IU) is feasible and safe...
March 1, 2024: Journal of Acute Medicine
https://read.qxmd.com/read/38487520/effective-extraction-and-determination-of-24-quinolones-in-water-and-egg-samples-using-a-novel-magnetic-covalent-organic-framework-combined-with-uplc-ms-ms
#38
JOURNAL ARTICLE
Na Li, Mengnan Liang, Hao Zhang, Zhongxia Hua, Ling Ma, Yanyu Qi, Ke Wang
The excessive use of quinolones (QNs) has seriously threatened human health. In this study, a novel functionalized magnetic covalent organic framework Fe3 O4 @SiO2 @Ah-COF was fabricated with biphenyl-3,3',5,5'-tetracarbaldehyde and hydrazine hydrate (85%) as monomers and was used as a magnetic solid-phase extraction (MSPE) absorbent for the determination of 24 QNs in water and egg samples through ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The extraction parameters of MSPE were optimized, including pH, adsorbent dosage, adsorption time, and eluent type...
March 6, 2024: RSC Advances
https://read.qxmd.com/read/38487333/long-term-treatment-with-perampanel-of-chinese-patients-with-focal-onset-seizures-especially-in-sleep-related-epilepsy-a-prospective-real-world-observational-study
#39
JOURNAL ARTICLE
Ye Xu, Qinyue Wang, Yufei Zhang, Yuncan Chen, Lan Xu, Guoxing Zhu, Chunlai Ma, Xunyi Wu
BACKGROUND: There is currently a lack of studies examining the long-term therapeutic effectiveness of the third-generation anti-sezure medication, perampanel (PER), for focal-onset seizures (FOS), particularly in Chinese patients with sleep-related epilepsy (SRE). Additionally, the appropriate dosage, plasma concentration, and the relationship between dose and plasma concentration of PER in Chinese patients are still uncertain. METHODS: A prospective, single-center, 24-month observational study was conducted in patients diagnosed with FOS, with a focus on patients with SRE...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38487172/a-comprehensive-evaluation-of-the-therapeutic-potential-of-silibinin-a-ray-of-hope-in-cancer-treatment
#40
REVIEW
Pantha Prodip Ray, Mohammad Ashraful Islam, Mohammad Safiqul Islam, Aixia Han, Peiwu Geng, Md Abdul Aziz, Abdullah Al Mamun
Natural compounds hold promise in the search for cancer therapies due to their unique chemical structures and combinations that may effectively combat cancer while minimizing toxicity and side effects compared to conventional treatments. Silibinin, a natural lignan, has been found to possess strong anti-cancer activity against several types of human cancers based on emerging research. This study aims to provide an overview of the therapeutic potential of silibinin in the treatment and prevention of cancers...
2024: Frontiers in Pharmacology
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