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https://www.readbyqxmd.com/read/27933586/preparation-and-optimization-of-meropenem-loaded-solid-lipid-nanoparticles-in-vitro-evaluation-and-molecular-modeling
#1
Ellen K G Mhango, Rahul S Kalhapure, Mahantesh Jadhav, Sandeep J Sonawane, Chunderika Mocktar, Suresh Vepuri, Mahmoud Soliman, Thirumala Govender
Encapsulation of antibiotics into nanocarriers has the potential to overcome resistance and disadvantages associated with conventional dosage forms as well as increase half-life of an antibiotic. Encapsulation of meropenem (MRPN) into solid lipid nanoparticles (SLNs) remains unexplored among the limited work reported on nanoformulation incorporating MRPN. The study aimed to use an experimental design, to optimize MRPN-loaded SLNs, and to undertake in vitro and in silico evaluations. A Box-Behnken design (BBD) was used to optimize manufacturing conditions of glycerol monostearate (GMS) SLNs loaded with MRPN...
December 8, 2016: AAPS PharmSciTech
https://www.readbyqxmd.com/read/27933497/a-review-and-investigation-of-the-effect-of-nanophotocatalytic-ozonation-process-for-phenolic-compound-removal-from-real-effluent-of-pulp-and-paper-industry
#2
Hamed Biglari, Mojtaba Afsharnia, Vali Alipour, Rasoul Khosravi, Kiomars Sharafi, Amir Hossein Mahvi
Phenol and its derivatives are the major environmental pollutants discharged from paper and pulp industries into water bodies. All these compounds and chlorinated phenolic compounds in particular are very toxic to fauna and flora, even at relatively low concentration. This study aimed to investigate the removal rate of phenolic compounds from the effluent of pulp and paper industries using a combination of ozonation and photocatalytic processes. Firstly, a certain volume from the effluent of paper and pulp industries containing certain phenol concentrations was obtained and fed into a prefabricated reactor at laboratory scale...
December 8, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27933391/-tapering-and-termination-of-immunosuppressive-treatment-in-spondyloarthritides-including-psoriatic-arthritis
#3
REVIEW
G Scholz, B Möller
BACKGROUND: Immunomodulatory long-term treatment has also become the standard treatment for spondyloarthritides (SpA), including psoriatic arthritis (PsA); however, uncertainty exists about dose reduction or termination of treatment after remission or low disease activity. OBJECTIVE: When is it possible to reduce medication or terminate treatment for SpA? MATERIAL AND METHODS: An extensive non-systematic literature search was performed focusing on practice guidelines, systematic meta-analyses and clinical trials on medicinal long-term treatment and voluntary medication reduction in axial and peripheral SpA, including PsA...
December 8, 2016: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/27933375/a-novel-method-of-adrenal-venous-sampling-via-an-antecubital-approach
#4
Xiongjing Jiang, Hui Dong, Meng Peng, Wuqiang Che, Yubao Zou, Lei Song, Huimin Zhang, Haiying Wu
PURPOSE: Currently, almost all adrenal venous sampling (AVS) procedures are performed by femoral vein access. The purpose of this study was to establish the technique of AVS via an antecubital approach and evaluate its safety and feasibility. MATERIALS AND METHODS: From January 2012 to June 2015, 194 consecutive patients diagnosed as primary aldosteronism underwent AVS via an antecubital approach without ACTH simulation. Catheters used for bilateral adrenal cannulations were recorded...
December 8, 2016: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/27933366/deficits-in-autonomic-indices-of-emotion-regulation-and-reward-processing-associated-with-prescription-opioid-use-and-misuse
#5
Eric L Garland, Craig J Bryan, Yoshio Nakamura, Brett Froeliger, Matthew O Howard
RATIONALE: Prescription opioid misuse and high-dose opioid use may result in allostatic dysregulation of hedonic brain circuitry, leading to reduced emotion regulation capacity. In particular, opioid misuse may blunt the ability to experience and upregulate positive affect from natural rewards. OBJECTIVES: The purpose of this study was to examine associations between opioid use/misuse and autonomic indices of emotion regulation capability in a sample of chronic pain patients receiving prescription opioid pharmacotherapy...
December 8, 2016: Psychopharmacology
https://www.readbyqxmd.com/read/27933328/predictors-of-emesis-in-children-undergoing-procedural-sedation-with-intramuscular-ketamine-in-a-paediatric-emergency-department
#6
Shruthi Suryaprakash, Lai Peng Tham
INTRODUCTION: Emesis is one of the most common adverse events associated with ketamine sedation. However, the predictors of emesis have not been clearly studied among Asian children. This study aimed to determine the incidence and predictors of emesis in local children undergoing intramuscular (IM) ketamine sedation in the emergency department (ED), and identify high-risk groups(s), so that antiemetics may be administered prophylactically. METHODS: In a prospective observational study, all children requiring procedural sedation under IM ketamine in the paediatric ED between 1 April 2013 and 31 January 2015 were included...
December 9, 2016: Singapore Medical Journal
https://www.readbyqxmd.com/read/27932882/sustained-release-liquisolid-compact-tablets-containing-artemether-lumefantrine-as-alternate-day-regimen-for-malaria-treatment-to-improve-patient-compliance
#7
Petra Obioma Nnamani, Agatha Adaora Ugwu, Emmanuel Chinedu Ibezim, Franklin Chimaobi Kenechukwu, Paul Achile Akpa, John-Dike Nwabueze Ogbonna, Nicholas Chinedu Obitte, Amelia Ngozi Odo, Maike Windbergs, Claus-Michael Lehr, Anthony Amaechi Attama
The present study aimed to develop low-dose liquisolid tablets of two antimalarial drugs artemether-lumefantrine (AL) from a nanostructured lipid carrier (NLC) of lumefantrine (LUM) and estimate the potential of AL as an oral delivery system in malariogenic Wistar mice. LUM-NLCs were prepared by hot homogenization using Precirol(®) ATO 5/Transcutol(®) HP and tallow fat/Transcutol(®) HP optimized systems containing 3:1 ratios of the lipids, respectively, as the matrices. LUM-NLC characteristics, including morphology, particle size, zeta potential, encapsulation efficiency, yield, pH-dependent stability, and interaction studies, were investigated...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27932668/quantitative-flow-measurement-after-placing-a-flow-diverter-for-a-distal-internal-carotid-artery-aneurysm
#8
Chien-Wei Chen, Ho-Fai Wong, Yu-Ling Ye, Yao-Liang Chen, Wei-Liang Chen, Chang-Hsien Ou, Yuan-Hsiung Tsai
OBJECTIVES: To evaluate the differences in arterial flow after flow diverter placement using quantitative flow measurements based on digital subtraction angiography (DSA). METHODS: Between November 2013 and November 2015, all patients who had flow diverters placed for distal internal carotid artery (ICA) aneurysms were reviewed. Patients in whom the stent was placed across the ostia of the ophthalmic artery (OphA) and anterior choroidal artery (AChA) were enrolled...
December 8, 2016: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/27932412/universal-haplotype-based-noninvasive-prenatal-testing-for-single-gene-diseases
#9
Winnie W I Hui, Peiyong Jiang, Yu K Tong, Wing-Shan Lee, Yvonne K Y Cheng, Maria I New, Rezan A Kadir, K C Allen Chan, Tak Y Leung, Y M Dennis Lo, Rossa W K Chiu
BACKGROUND: Researchers have developed approaches for the noninvasive prenatal testing of single gene diseases. One approach that allows for the noninvasive assessment of both maternally and paternally inherited mutations involves the analysis of single nucleotide polymorphisms (SNPs) in maternal plasma DNA with reference to parental haplotype information. In the past, parental haplotypes were resolved by complex experimental methods or inferential approaches, such as through the analysis of DNA from other affected family members...
December 8, 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27931932/susceptibility-of-rhipicephalus-boophilus-microplus-to-fluazuron-2-5mg-kg-and-a-combination-of-novaluron-2-0mg-kg-eprinomectin-0-36mg-kg-in-field-studies-in-brazil
#10
Willian Giquelin Maciel, Welber Daniel Zanetti Lopes, Lucas Vinicius Costa Gomes, Breno Cayeiro Cruz, Gustavo Felippelli, Isabella Barbosa Dos Santos, Fernando de Almeida Borges, Walter Antonio Gonçalves, Alexandre Braga Scarpa, João Eduardo Nicaretta, Thiago Souza Azeredo Bastos, Alvimar José da Costa
The present study aimed to determine the susceptibility of 32 R. (B.) microplus populations from Southeast, Midwest and South regions of Brazil, to fluazuron (2.5mg/kg), administered topically (pour-on). Additionally, five populations (Southeast and Midwest regions) of the southern cattle tick were evaluated using in vivo field studies, regarding their susceptibility to a new combination of novaluron (2.0mg/kg)+eprinomectin (0.36mg/kg), administered subcutaneously, compared with two positive controls (fluazuron 2...
December 1, 2016: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/27931805/evaluation-of-single-dose-rbc-pig-a-and-pigret-assays-in-detecting-the-mutagenicity-of-thiotepa-in-rats
#11
Eri Tsutsumi, Ayaka Momonami, Hisako Hori, Yoshinori Kitagawa
The Pig-a assay, which uses reticulocytes (PIGRET assay) as target cells, is anticipated to detect mutagenicity at earlier time points than the RBC Pig-a assay, which uses all red blood cells as target cells. As part of a collaborative study conducted by the Mammalian Mutagenicity Study (MMS) Group, we evaluated the PIGRET and RBC Pig-a assays to detect Pig-a gene mutations induced by the carcinogen thiotepa. A single dose of thiotepa at 7.5, 15, and 30mg/kg was administered to 8-week-old male Sprague-Dawley rats by oral gavage...
November 15, 2016: Mutation Research
https://www.readbyqxmd.com/read/27931784/learning-from-patients-identifying-design-features-of-medicines-that-cause-medication-use-problems
#12
Kim Notenboom, Hubert Gm Leufkens, Herman Vromans, Marcel L Bouvy
Usability is a key factor in ensuring safe and efficacious use of medicines. However, several studies showed that people experience a variety of problems using their medicines. The purpose of this study was to identify design features of oral medicines that cause use problems among older patients in daily practice. A qualitative study with semi-structured interviews on the experiences of older people with the use of their medicines was performed (n=59). Information on practical problems, strategies to overcome these problems and the medicines' design features that caused these problems were collected...
December 5, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27931583/acute-graft-vs-host-disease-after-liver-transplantation-experience-at-a-high-volume-liver-transplantation-center-in-korea
#13
W H Kang, S Hwang, G W Song, D H Jung, G C Park, C S Ahn, D B Moon, K H Kim, T Y Ha, W J Kim, S H Kim, H D Cho, J H Kwon, E K Jwa, S G Lee
BACKGROUND: Acute graft-vs-host disease (GVHD) is a rare but life-threatening complication of orthotopic liver transplantation (OLT). We present 6 cases of GVHD after OLT. METHODS: Among our 4294 OLT recipients, we identified 6 patients (0.14%) who were diagnosed with GVHD. Their medical records were reviewed retrospectively. RESULTS: Liver graft types included deceased donor whole liver graft (n = 3) and right liver graft from son (n = 3)...
December 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27931323/lidocaine-hydrochloride-compared-with-ms222-for-the-euthanasia-of-zebrafish-danio-rerio
#14
Chereen Collymore, E Kate Banks, Patricia V Turner
Despite several shortcomings, MS222 is the most commonly used chemical agent for euthanasia of zebrafish. Although lidocaine hydrochloride has some advantages over MS222, its effectiveness as a euthanasia agent for zebrafish is unknown. Larvae at 9 to 16 d postfertilization were exposed to 250 mg/L MS222 or 400, 500, 600, 700, 800, 900, or 1000 mg/L lidocaine and observed for cessation of heartbeat. Adult zebrafish were exposed to 250 mg/L MS222 or 400, 500, or 600 mg/L lidocaine; times to loss of righting reflex, cessation of opercular movement, and complete recovery; body length; aversive behavior; and gross and microscopic evidence of acute toxicity were evaluated...
November 2016: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/27931319/subcutaneous-compared-with-intraperitoneal-ketaminexylazine-for-anesthesia-of-mice
#15
Maya Levin-Arama, Lital Abraham, Trevor Waner, Alon Harmelin, David M Steinberg, Tal Lahav, Mickey Harlev
Mice are commonly anesthetized intraperitoneally with a ketamine-xylazine (KX) solution. Although this route of administration allows rapid uptake of the injected drugs, its disadvantages and potential risks include pain, peritoneal irritation, and perforation of an abdominal organ; some of the risks depend on the operator's experience. We compared the efficacy of intraperitoneal and subcutaneous administration of KX in HSD:ICR, BALB/cOlaHsd, and C57BL/6JOlaHsd mice in terms of time to onset and duration of surgical anesthesia, procedure safety, and mortality...
November 2016: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/27931213/assessment-of-core-drug-use-indicators-using-who-inrud-methodology-at-primary-healthcare-centers-in-bahawalpur-pakistan
#16
Muhammad Atif, Muhammad Rehan Sarwar, Muhammad Azeem, Mubeen Naz, Salma Amir, Kashaf Nazir
BACKGROUND: Proper utilization of medicines is a critical component of pharmaceutical care plan. The aim of this study was to assess drug use pattern at ten primary healthcare centers (PHCCs) of the Bahawalpur district of the Punjab province of Pakistan by employing the WHO/INRUD core drug use indicators. METHODS: This was a descriptive, non-experimental and cross-sectional study. For the prescribing indicators, 1000 prescriptions (100 prescriptions per PHCC) were systematically sampled out of the total 290,000 prescriptions written during January to December 2014...
December 8, 2016: BMC Health Services Research
https://www.readbyqxmd.com/read/27931163/preparation-characterization-and-in-vitro-anticoagulant-activity-of-corn-stover-xylan-sulfates
#17
He-Li Cheng, Hao Liu, Qing-Hua Feng, Yi-Min Xie, Huai-Yu Zhan
A new anticoagulant agent was prepared by introducing sulfate groups into corn stover xylan through homogeneous reactions. Three organic solvents, N, N-dimethylformamide (DMF), dimethyl sulfoxide (DMSO) and formamide (FA), were adopted as reaction media, with the assistance of LiCl. Structural characterization by FT-IR and (13)CNMR showed that xylan sulfate (XS) could be successfully synthesized with SO3∙Pyridine (SO3∙Py) complexes sulfation reagent in the three media. The effect of sulfation temperature, sulfation time, media type and molar ratio of -SO3/-OH on the degree of substitution (DS) and degree of the polymerization (DP) were studied...
December 8, 2016: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/27930973/phytosomal-curcumin-a-review-of-pharmacokinetic-experimental-and-clinical-studies
#18
REVIEW
Hamed Mirzaei, Abolfazl Shakeri, Bahman Rashidi, Amin Jalili, Zarrin Banikazemi, Amirhossein Sahebkar
Curcumin, a hydrophobic polyphenol, is the principal constituent extracted from dried rhizomes of Curcuma longa L. (turmeric). Curcumin is known as a strong anti-oxidant and anti-inflammatory agent that has different pharmacological effects. In addition, several studies have demonstrated that curcumin is safe even at dosages as high as 8g per day; however, instability at physiological pH, low solubility in water and rapid metabolism results in a low oral bioavailability of curcumin. The phytosomal formulation of curcumin (a complex of curcumin with phosphatidylcholine) has been shown to improve curcumin bioavailability...
December 5, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27930860/long-term-real-time-in-vivo-drug-release-monitoring-with-aie-thermogelling-polymer
#19
Sing Shy Liow, Qingqing Dou, Dan Kai, Zibiao Li, Sigit Sugiarto, Chris Yee Yung Yu, Ryan Tsz Kin Kwok, Xiaohong Chen, Yun-Long Wu, Seow Theng Ong, Atish Kizhakeyil, Navin K Verma, Ben Zhong Tang, Xian Jun Loh
A new drug concentration meter is developed. In vivo drug release can be monitored precisely via a self-indicating drug delivery system consisting of a new aggregation-induced emission thermoresponsive hydrogel. By taking the advantage of a self-indicating system, one can easily detect the depletion of drugs, and reinject to maintain a dosage in the optimal therapeutic window.
December 8, 2016: Small
https://www.readbyqxmd.com/read/27930655/effect-of-immunosuppressive-drugs-on-the-changes-of-serum-galactose-deficient-iga1-in-patients-with-iga-nephropathy
#20
Min Jeong Kim, Stefan Schaub, Karen Molyneux, Michael T Koller, Susanne Stampf, Jonathan Barratt
Galactose-deficient IgA1 (Gd-IgA1) and IgA-IgG complexes are known to play an important role in the pathogenesis of IgA nephropathy (IgAN). We aimed therefore to determine the impact of immunosuppression on the serum levels of Gd-IgA1, total IgA1 and IgA-IgG complexes in IgAN patients. In a retrospective study, serum samples from IgAN patients collected before transplantation (t0) and at 3- and 6-month posttransplant (t3 & t6) were used to measure the levels of Gd-IgA1, total IgA1 and IgA-IgG complexes. The area under the curves (AUC) of immunosuppressants was calculated by the plot of plasma trough level or dosage of each immunosuppressant versus time and was interpreted as the extent of drug exposure...
2016: PloS One
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