keyword
https://read.qxmd.com/read/38509046/prolonged-hourly-neurologic-examinations-are-associated-with-increased-delirium-and-no-discernible-benefit-in-mild-moderate-geriatric-traumatic-brain-injury
#1
JOURNAL ARTICLE
Ricardo Alejandro Fonseca Ruiz, Melissa Canas, Leonardo Diaz, Jose Alejandro Aldana, Hussain Afzal, Alejandro De Filippis Falcon, Drew Del Toro, Aaron Day, Jennifer McCarthy, Kristin Stansfield, Grant V Bochicchio, Grace Niziolek, Lindsay M Kranker, Matthew R Rosengart, Mark Hoofnagle, Jennifer Leonard
BACKGROUND: Serial neurologic examinations (NE) are routinely recommended in the ICU within the first 24 hours following a TBI. There are currently no widely accepted guidelines for the frequency of NE. Disruptions to the sleep-wake cycles increase the delirium rate. We aimed to evaluate whether there is a correlation between prolonged Q1-NE and development of delirium and to determine if this practice reduces the likelihood of missing the detection of a process requiring emergent intervention...
March 21, 2024: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/38504558/risk-management-and-decision-making-in-dementia-care
#2
JOURNAL ARTICLE
Zena Aldridge, Karen Harrison Dening
What constitutes a risk for a person living with dementia may be perceived and prioritised differently by nurses from varying clinical backgrounds. Furthermore, risk may be perceived differently according to the context. This article outlines some of the social, psychological and physical risk factors relevant to people living with dementia across the life course of the condition. It is important that nurses understand their role in identifying, assessing and managing risk and are aware of the resources, policies, legislation and processes designed to support decision-making and minimise the risk of harm to people living with dementia, their families and carers...
March 20, 2024: Nursing Older People
https://read.qxmd.com/read/38481342/differences-in-the-treatment-needs-of-patients-with-dementia-with-lewy-bodies-and-their-caregivers-and-differences-in-their-physicians-awareness-of-those-treatment-needs-according-to-the-clinical-department-visited-by-the-patients-a-subanalysis-of-an-observational
#3
JOURNAL ARTICLE
Manabu Ikeda, Shunji Toya, Yuta Manabe, Hajime Yamakage, Mamoru Hashimoto
BACKGROUND: We investigated whether the treatment needs of patients with dementia with Lewy bodies (DLB) and their caregivers, along with their attending physicians' perception of those treatment needs, differ according to the clinical department visited by the patients. METHODS: This was a subanalysis of a multicenter, cross-sectional, observational survey study. Data from the main study were classified according to the clinical department visited by the patient: psychiatric group (P-group), geriatric internal medicine group (G-group), and neurology group (N-group)...
March 14, 2024: Alzheimer's Research & Therapy
https://read.qxmd.com/read/38466515/the-potential-use-of-nanozyme-in-aging-and-age-related-diseases
#4
REVIEW
Amirsasan Gorgzadeh, Paria Arab Amiri, Saman Yasamineh, Basim Kareem Naser, Khairia Abdulrahman Abdulallah
The effects of an increasingly elderly population are among the most far-reaching in 21st-century society. The growing healthcare expense is mainly attributable to the increased incidence of chronic illnesses that accompany longer life expectancies. Different ideas have been put up to explain aging, but it is widely accepted that oxidative damage to proteins, lipids, and nucleic acids contributes to the aging process. Increases in life expectancy in all contemporary industrialized cultures are accompanied by sharp increases in the prevalence of age-related diseases such as cardiovascular and neurological conditions, type 2 diabetes, osteoporosis, and cancer...
March 11, 2024: Biogerontology
https://read.qxmd.com/read/38462968/validation-of-the-japanese-version-of-the-social-functioning-in-dementia-scale-and-covid-19-pandemic-s-impact-on-social-function-in-mild-cognitive-impairment-and-mild-dementia
#5
JOURNAL ARTICLE
Sumiyo Umeda, Hideki Kanemoto, Maki Suzuki, Tamiki Wada, Takashi Suehiro, Kyosuke Kakeda, Yoshitaka Nakatani, Yuto Satake, Maki Yamakawa, Fuyuki Koizumi, Daiki Taomoto, Sakura Hikida, Natsuho Hirakawa, Andrew Sommerlad, Gill Livingston, Mamoru Hashimoto, Kenji Yoshiyama, Manabu Ikeda
OBJECTIVES: We aimed to psychometrically evaluate and validate a Japanese version of the Social Functioning in Dementia scale (SF-DEM-J) and investigate changes in social function in people with dementia during the coronavirus disease-19 (COVID-19) pandemic. DESIGN: We interviewed people with mild cognitive impairment (MCI) and mild dementia and their caregivers during June 2020-March 2021 to validate patient- and caregiver-rated SF-DEM-J and compared their scores at baseline (April 2020 to May 2020) and at 6-8 months (January 2021 to March 2021) during a time of tighter COVID-19 restrictions...
March 11, 2024: International Psychogeriatrics
https://read.qxmd.com/read/38462665/impact-of-malnutrition-on-mortality-and-neurological-recovery-of-older-patients-with-spinal-cord-injury
#6
JOURNAL ARTICLE
Koji Tamai, Hidetomi Terai, Hiroaki Nakamura, Noriaki Yokogawa, Takeshi Sasagawa, Hiroaki Nakashima, Naoki Segi, Sadayuki Ito, Toru Funayama, Fumihiko Eto, Akihiro Yamaji, Kota Watanabe, Junichi Yamane, Kazuki Takeda, Takeo Furuya, Atsushi Yunde, Hideaki Nakajima, Tomohiro Yamada, Tomohiko Hasegawa, Yoshinori Terashima, Ryosuke Hirota, Hidenori Suzuki, Yasuaki Imajo, Shota Ikegami, Masashi Uehara, Hitoshi Tonomura, Munehiro Sakata, Ko Hashimoto, Yoshito Onoda, Kenichi Kawaguchi, Yohei Haruta, Nobuyuki Suzuki, Kenji Kato, Hiroshi Uei, Hirokatsu Sawada, Kazuo Nakanishi, Kosuke Misaki, Akiyoshi Kuroda, Gen Inoue, Kenichiro Kakutani, Yuji Kakiuchi, Katsuhito Kiyasu, Hiroyuki Tominaga, Hiroto Tokumoto, Yoichi Iizuka, Eiji Takasawa, Koji Akeda, Norihiko Takegami, Haruki Funao, Yasushi Oshima, Takashi Kaito, Daisuke Sakai, Toshitaka Yoshii, Tetsuro Ohba, Bungo Otsuki, Shoji Seki, Masashi Miyazaki, Masayuki Ishihara, Seiji Okada, Shiro Imagama, Satoshi Kato
This retrospective cohort study established malnutrition's impact on mortality and neurological recovery of older patients with cervical spinal cord injury (SCI). It included patients aged ≥ 65 years with traumatic cervical SCI treated conservatively or surgically. The Geriatric Nutritional Risk Index was calculated to assess nutritional-related risk. Overall, 789 patients (mean follow-up: 20.1 months) were examined and 47 had major nutritional-related risks on admission. One-year mortality rate, median survival time, neurological recovery, and activities of daily living (ADL) at 1 year post-injury were compared between patients with major nutrition-related risk and matched controls selected using 1:2 propensity score matching to adjust for age, pre-traumatic neurological impairment, and activity...
March 11, 2024: Scientific Reports
https://read.qxmd.com/read/38462585/demographic-biochemical-clinical-%C3%A2-and-cognitive%C3%A2-symptom%C3%A2-differences-between-smokers%C3%A2-and%C3%A2-non-smokers%C3%A2-in-chinese%C3%A2-older%C3%A2-male-patients-with-chronic-schizophrenia
#7
JOURNAL ARTICLE
Wei Li, Ling Yue, Shifu Xiao
BACKGROUND: Several studies have suggested that smoking may impair cognitive function and worsen psychiatric symptoms in people with schizophrenia, but the results have not been consistent. There have been few studies to date that have examined the effects of smoking in older men with chronic schizophrenia. METHODS: The participants in our study consisted of 167 order Chinese males with chronic schizophrenia and 359 normal control subjects. We split them into smoking and non-smoking groups based on whether or not they smoked...
March 10, 2024: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/38459948/apoe-genotype-disclosure-influences-decisions-about-future-planning-but-not-adoption-of-healthy-lifestyle-changes-in-cognitively-unimpaired-individuals
#8
JOURNAL ARTICLE
Dominique L Popescu, Athene K Lee, Edmund Arthur, Louisa I Thompson, Jessica Alber
BACKGROUND: Studies have shown apolipoprotein E (APOE) genotype disclosure to be safe and well-tolerated in cognitively unimpaired (CU) older adults. This study aimed to examine the effect of the disclosure process on decisions about future directives and health behaviors in community-dwelling CU older adults from the Butler Alzheimer's Prevention Registry (BAPR). METHODS: CU APOE E4 non-carriers (n = 106) and carriers (n = 80) aged 58-78 completed in-person psychological readiness screening to undergo APOE disclosure...
March 9, 2024: Journal of Geriatric Psychiatry and Neurology
https://read.qxmd.com/read/38453478/comparing-ocrelizumab-to-interferon-glatiramer-acetate-in-people-with-multiple-sclerosis-over-age-60
#9
JOURNAL ARTICLE
Yi Chao Foong, Daniel Merlo, Melissa Gresle, Katherine Buzzard, Michael Zhong, Wei Zhen Yeh, Vilija Jokubaitis, Mastura Monif, Olga Skibina, Serkan Ozakbas, Francesco Patti, Pierre Grammond, Maria Pia Amato, Tomas Kalincik, Dana Horakova, Eva Kubala Havrdova, Bianca Weinstock-Guttman, Jeanette Lechner Scott, Cavit Boz, Maria Jose Sa, Helmut Butzkueven, Anneke van der Walt, Chao Zhu
BACKGROUND: Ongoing controversy exists regarding optimal management of disease modifying therapy (DMT) in older people with multiple sclerosis (pwMS). There is concern that the lower relapse rate, combined with a higher risk of DMT-related infections and side effects, may alter the risk-benefit balance in older pwMS. Given the lack of pwMS above age 60 in randomised controlled trials, the comparative efficacy of high-efficacy DMTs such as ocrelizumab has not been shown in older pwMS. We aimed to evaluate the comparative effectiveness of ocrelizumab, a high-efficacy DMT, versus interferon/glatiramer acetate (IFN/GA) in pwMS over the age of 60...
March 7, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/38451341/electroencephalographic-guided-propofol-remifentanil-tci-anesthesia-with-and-without-dexmedetomidine-in-a-geriatric-population-electroencephalographic-signatures-and-clinical-evaluation
#10
JOURNAL ARTICLE
Dominik M Mehler, Matthias Kreuzer, David P Obert, Luis F Cardenas, Ignacio Barra, Fernando Zurita, Francisco A Lobo, Stephan Kratzer, Gerhard Schneider, Pablo O Sepúlveda
Elderly and multimorbid patients are at high risk for developing unfavorable postoperative neurocognitive outcomes; however, well-adjusted and EEG-guided anesthesia may help titrate anesthesia and improve postoperative outcomes. Over the last decade, dexmedetomidine has been increasingly used as an adjunct in the perioperative setting. Its synergistic effect with propofol decreases the dose of propofol needed to induce and maintain general anesthesia. In this pilot study, we evaluate two highly standardized anesthetic regimens for their potential to prevent burst suppression and postoperative neurocognitive dysfunction in a high-risk population...
March 7, 2024: Journal of Clinical Monitoring and Computing
https://read.qxmd.com/read/38445606/physical-exercise-for-treating-the-anxiety-and-depression-symptoms-of-parkinson-s-disease-systematic-review-and-meta-analysis
#11
REVIEW
Valton Costa, José Mario Prati, Alice de Oliveira Barreto Suassuna, Thanielle Souza Silva Brito, Thalita Frigo da Rocha, Anna Carolyna Gianlorenço
BACKGROUND: Depression and anxiety are non-motor symptoms of Parkinson's disease (PD). Physical exercise is a promising approach to reducing neuropsychological burden. We aimed to comprehensively synthesize evidence regarding the use of exercise for treating depression and anxiety symptoms in PD. METHODS: Systematic review and meta-analysis following PRISMA recommendations. Searches on PubMed, Cochrane Library, Scopus, Web of Science, Embase, and Physiotherapy Evidence Database (PEDro) was conducted...
March 6, 2024: Journal of Geriatric Psychiatry and Neurology
https://read.qxmd.com/read/38444165/using-therapeutic-lies-an-ethical-challenge-for-nurses-when-caring-for-people-with-dementia
#12
JOURNAL ARTICLE
Jane Pritchard
People living with dementia can become vulnerable when experiencing symptoms such as memory loss and disorientation, as well as stigma attached to the condition. The care of people with dementia is fraught with ethical dilemmas and challenges regarding how nurses should respond to situations that put patients at risk of distress. For example, if a person with dementia asks to see a deceased relative, a nurse may have to decide whether to tell the truth, or a 'white lie' to avoid distress. This article examines the debates around the use of such 'therapeutic lying' when caring for people with dementia and provides guidance on how nurses could use this technique while protecting the individual's best interests...
March 6, 2024: Nursing Older People
https://read.qxmd.com/read/38436576/forecasted-dementia-prevalence-in-portugal-2020-2080
#13
JOURNAL ARTICLE
Sara Alves, Natália Duarte, Barbara Gomes
Dementia is a global public health challenge, and its impact on Portugal is yet unclear. This study forecasts dementia prevalence in Portugal until 2080. Using the Gonçalves-Pereira et al (2021) method, we estimated dementia cases among older adults (≥65 years) in the community. Applying age-sex specific prevalence rates of the Gonçalves-Pereira study to population projections for Portugal between 2020-2080, based on the 10/66 Dementia Research Group criteria (10/66 DRG) and the Diagnostic and Statistical Manual of Mental Disorders IV criteria (DSM-IV), to Portugal's population projections (2020-2080) under various growth scenarios (low, medium, and high)...
March 4, 2024: Journal of Geriatric Psychiatry and Neurology
https://read.qxmd.com/read/38435400/emerging-t-cell-immunoregulatory-mechanisms-in-multiple-sclerosis-and-alzheimer-s-disease
#14
REVIEW
Daniel Hawiger
Multiple sclerosis (MS) and Alzheimer's disease (AD) are neuroinflammatory and neurodegenerative diseases with considerable socioeconomic impacts but without definitive treatments. AD and MS have multifactorial pathogenesis resulting in complex cognitive and neurologic symptoms and growing evidence also indicates key functions of specific immune cells. Whereas relevant processes dependent on T cells have been elucidated in both AD and MS, mechanisms that can control such immune responses still remain elusive...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38427140/endovascular-coiling-versus-neurosurgical-clipping-in-the-management-of-aneurysmal-subarachnoid-haemorrhage-in-the-elderly-a-multicenter-cohort-study
#15
MULTICENTER STUDY
Keng Siang Lee, Isabel Siow, Lily Wy Yang, Aaron Sc Foo, John Jy Zhang, Ian Mathews, Chun Peng Goh, Colin Teo, Bolem Nagarjun, Vanessa Chen, Sein Lwin, Kejia Teo, Shiong Wen Low, Ira Sy Sun, Boon Chuan Pang, Eugene Wr Yang, Cunli Yang, Anil Gopinathan, Tseng Tsai Yeo, Vincent Dw Nga
The comparability of endovascular coiling over neurosurgical clipping has not been firmly established in elderly patients with aneurysmal subarachnoid haemorrhage (aSAH). Data were obtained from all patients with aSAH aged ≥60 across three tertiary hospitals in Singapore from 2014 to 2019. Outcome measures included modified Rankin Scale (mRS) score at 3 and at 6 months, and in-hospital mortality. Of the 134 patients analyzed, 84 (62.7%) underwent coiling and 50 (37.3%) underwent clipping. The endovascular group showed a higher incidence of good mRS score 0-2 at 3 months (OR = 2...
March 1, 2024: Neurosurgical Review
https://read.qxmd.com/read/38426174/factors-associated-with-older-adults-cognitive-decline-6-months-after-gamma-variant-sars-cov-2-infection
#16
JOURNAL ARTICLE
Vanessa Giffoni M N P Peixoto, Lucas Alves Facci, Thiago C S Barbalho, Raíssa Nascimento Souza, Alice Mendes Duarte, Marina Bruxel Dos Santos, Katie Moraes Almondes
BACKGROUND: Cognitive deficits are commonly reported after COVID-19 recovery, but little is known in the older population. This study aims to investigate possible cognitive damage in older adults 6 months after contracting COVID-19, as well as individual risk factors. METHODS: This cross-sectional study involved 70 participants aged 60-78 with COVID-19 6 months prior and 153 healthy controls. Montreal Cognitive Assessment-Basic (MoCA-B) screened for cognitive impairment; Geriatric Depression Scale and Geriatric Anxiety Inventory screened for depression and anxiety...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38425785/high-frequency-multimodal-training-with-a-focus-on-tai-chi-in-people-with-parkinson-s-disease-a-pilot-study
#17
JOURNAL ARTICLE
Ketevan Toloraia, Ute Gschwandtner, Peter Fuhr
BACKGROUND AND OBJECTIVES: Cognitive decline is an important and common complication in patients with Parkinson's disease (PD) since it significantly reduces the quality of life. A breakthrough in treating and preventing cognitive decline in PD remains to be achieved. This study aimed to evaluate the effectiveness of high-frequency and intensive multimodal training in improving motor and cognitive function. METHODS: Twenty-eight patients diagnosed with idiopathic PD completed a comprehensive neuropsychological test battery and were neurologically examined...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38416181/-prevention-of-dementia
#18
JOURNAL ARTICLE
Walter M Schippinger, Gerald Pichler
With increasing life expectancy, the prevalence of dementia is increasing worldwide. Dementia is among the greatest challenges for healthcare and social systems of the future. Approximately 40% of newly diagnosed cases of dementia are associated with risk factors that can potentially be influenced by preventive measures. Based on the evidence from longitudinal studies, systematic reviews and meta-analyses, the Lancet commission on dementia prevention, intervention and care has defined 12 risk factors that are associated with an increased risk for dementia: low level of education, hearing impairment, traumatic brain injury, arterial hypertension, diabetes mellitus, smoking, excessive alcohol consumption, depression, obesity, social isolation, and air pollution...
February 28, 2024: Der Nervenarzt
https://read.qxmd.com/read/38415699/factors-associated-with-longer-survival-among-older-medicare-patients-after-diagnosis-of-supratentorial-primary-brain-malignancies-a-retrospective-cohort-study
#19
JOURNAL ARTICLE
Anthony V Nguyen, Jose M Soto, Biai D Digbeu, Christine Y Nguyen, Erxi Wu, Jason H Huang, Yong-Fang Kuo
OBJECTIVES: Despite recent advances, the prognosis for primary malignant brain tumors (PMBTs) remains poor. Some commonly prescribed medications may exhibit anti-tumor properties in various cancers, and neurodegenerative diseases may activate pathways that counteract gliomagenesis. Our study is focused on determining if there is a correlation between the use of metformin, beta-blockers, angiotensin converting enzyme inhibitors (ACEIs), and angiotensin receptor blockers (ARBs), or the presence of Parkinson's disease (PD), and the survival rates following a diagnosis of a PMBT...
February 28, 2024: Neurological Research
https://read.qxmd.com/read/38414551/kinesiophobia-limits-of-stability-and-functional-balance-assessment-in-geriatric-patients-with-chronic-low-back-pain-and-osteoporosis-a-comprehensive-study
#20
JOURNAL ARTICLE
Mastour Saeed Alshahrani, Ravi Shankar Reddy
BACKGROUND: The significance of studying Kinesiophobia, Limits of Stability (LOS), and functional balance in geriatric patients with CLBP and osteoporosis lies in their profound impact on rehabilitation outcomes and fall risk, ultimately affecting patients' quality of life. This study aimed to examine LOS and functional balance in the geriatric population concurrently experiencing Chronic Low Back Pain (CLBP) and osteoporosis, in comparison to age-matched healthy controls; to assess the correlations between Kinesiophobia, LOS, and functional balance assessments; and to evaluate the mediating influence of Kinesiophobia on the association between LOS and functional balance tests...
2024: Frontiers in Neurology
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