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Apoe microbiota gut

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https://www.readbyqxmd.com/read/27821063/high-fat-diet-induced-atherosclerosis-is-accompanied-with-low-colonic-bacterial-diversity-and-altered-abundances-that-correlates-with-plaque-size-plasma-a-fabp-and-cholesterol-a-pilot-study-of-high-fat-diet-and-its-intervention-with-lactobacillus-rhamnosus
#1
Yee Kwan Chan, Manreetpal Singh Brar, Pirkka V Kirjavainen, Yan Chen, Jiao Peng, Daxu Li, Frederick Chi-Ching Leung, Hani El-Nezami
BACKGROUND: Atherosclerosis appears to have multifactorial causes - microbial component like lipopolysaccharides (LPS) and other pathogen associated molecular patterns may be plausible factors. The gut microbiota is an ample source of such stimulants, and its dependent metabolites and altered gut metagenome has been an established link to atherosclerosis. In this exploratory pilot study, we aimed to elucidate whether microbial intervention with probiotics L. rhamnosus GG (LGG) or pharmaceuticals telmisartan (TLM) could improve atherosclerosis in a gut microbiota associated manner...
November 8, 2016: BMC Microbiology
https://www.readbyqxmd.com/read/27725195/cardiovascular-health-effects-of-oral-and-pulmonary-exposure-to-multi-walled-carbon-nanotubes-in-apoe-deficient-mice
#2
Daniel V Christophersen, Nicklas R Jacobsen, Maria H G Andersen, Shea P Connell, Kenneth K Barfod, Morten B Thomsen, Mark R Miller, Rodger Duffin, Jens Lykkesfeldt, Ulla Vogel, Håkan Wallin, Steffen Loft, Martin Roursgaard, Peter Møller
Exposure to high aspect ratio nanomaterials, such as multi-walled carbon nanotubes (MWCNTs) may be associated with increased risk of atherosclerosis, pulmonary disease, and cancer. In the present study, we investigated the cardiovascular and pulmonary health effects of 10 weeks of repeated oral or pulmonary exposures to MWCNTs (4 or 40μg each week) in Apolipoprotein E-deficient (ApoE(-/-)) mice fed a Western-type diet. Intratracheal instillation of MWCNTs was associated with oxidative damage to DNA in lung tissue and elevated levels of lipid peroxidation products in plasma, whereas the exposure only caused a modest pulmonary inflammation in terms of increased numbers of lymphocytes in bronchoalveolar lavage fluid...
October 8, 2016: Toxicology
https://www.readbyqxmd.com/read/27696135/acrolein-increases-macrophage-atherogenicity-in-association-with-gut-microbiota-remodeling-in-atherosclerotic-mice-protective-role-for-the-polyphenol-rich-pomegranate-juice
#3
Oren Rom, Hila Korach-Rechtman, Tony Hayek, Yael Danin-Poleg, Haim Bar, Yechezkel Kashi, Michael Aviram
The unsaturated aldehyde acrolein is pro-atherogenic, and the polyphenol-rich pomegranate juice (PJ), known for its anti-oxidative/anti-atherogenic properties, inhibits macrophage foam cell formation, the hallmark feature of early atherosclerosis. This study aimed to investigate two unexplored areas of acrolein atherogenicity: macrophage lipid metabolism and the gut microbiota composition. The protective effects of PJ against acrolein atherogenicity were also evaluated. Atherosclerotic apolipoprotein E-deficient (apoE(-/-)) mice that were fed acrolein (3 mg/kg/day) for 1 month showed significant increases in serum and aortic cholesterol, triglycerides, and lipid peroxides...
September 30, 2016: Archives of Toxicology
https://www.readbyqxmd.com/read/27383250/adaptive-immunity-against-gut-microbiota-enhances-apoe-mediated-immune-regulation-and-reduces-atherosclerosis-and-western-diet-related-inflammation
#4
Diego Saita, Roberto Ferrarese, Chiara Foglieni, Antonio Esposito, Tamara Canu, Laura Perani, Elisa Rita Ceresola, Laura Visconti, Roberto Burioni, Massimo Clementi, Filippo Canducci
Common features of immune-metabolic and inflammatory diseases such as metabolic syndrome, diabetes, obesity and cardiovascular diseases are an altered gut microbiota composition and a systemic pro-inflammatory state. We demonstrate that active immunization against the outer membrane protein of bacteria present in the gut enhances local and systemic immune control via apoE-mediated immune-modulation. Reduction of western-diet-associated inflammation was obtained for more than eighteen weeks after immunization...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27143680/akkermansia-muciniphila-protects-against-atherosclerosis-by-preventing-metabolic-endotoxemia-induced-inflammation-in-apoe-mice
#5
Jin Li, Shaoqiang Lin, Paul M Vanhoutte, Connie W Woo, Aimin Xu
BACKGROUND: Altered composition of the gut microbiota is involved in both the onset and progression of obesity and diabetes mellitus. However, the link between gut microbiota and obesity-related cardiovascular complications has not been explored. The present study was designed to investigate the role of Akkermansia muciniphila, a mucin-degrading bacterium with beneficial effects on metabolism, in the pathogenesis of atherosclerosis in apolipoprotein E-deficient (Apoe(-/-)) mice. METHODS AND RESULTS: Apoe(-/-) mice on normal chow diet or a Western diet were treated with A muciniphila by daily oral gavage for 8 weeks, followed by histological evaluations of atherosclerotic lesion in aorta...
June 14, 2016: Circulation
https://www.readbyqxmd.com/read/27139829/crystal-structure-of-bile-salt-hydrolase-from-lactobacillus-salivarius
#6
Fuzhou Xu, Fangfang Guo, Xiao Jian Hu, Jun Lin
Bile salt hydrolase (BSH) is a gut-bacterial enzyme that negatively influences host fat digestion and energy harvesting. The BSH enzyme activity functions as a gateway reaction in the small intestine by the deconjugation of glycine-conjugated or taurine-conjugated bile acids. Extensive gut-microbiota studies have suggested that BSH is a key mechanistic microbiome target for the development of novel non-antibiotic food additives to improve animal feed production and for the design of new measures to control obesity in humans...
May 2016: Acta Crystallographica. Section F, Structural Biology Communications
https://www.readbyqxmd.com/read/27048804/resveratrol-attenuates-trimethylamine-n-oxide-tmao-induced-atherosclerosis-by-regulating-tmao-synthesis-and-bile-acid-metabolism-via-remodeling-of-the-gut-microbiota
#7
Ming-liang Chen, Long Yi, Yong Zhang, Xi Zhou, Li Ran, Jining Yang, Jun-dong Zhu, Qian-yong Zhang, Man-tian Mi
UNLABELLED: The gut microbiota is found to be strongly associated with atherosclerosis (AS). Resveratrol (RSV) is a natural phytoalexin with anti-AS effects; however, its mechanisms of action remain unclear. Therefore, we sought to determine whether the anti-AS effects of RSV were related to changes in the gut microbiota. We found that RSV attenuated trimethylamine-N-oxide (TMAO)-induced AS in ApoE(-/-) mice. Meanwhile, RSV decreased TMAO levels by inhibiting commensal microbial trimethylamine (TMA) production via gut microbiota remodeling in mice...
2016: MBio
https://www.readbyqxmd.com/read/26973703/heat-treated-high-fat-diet-modifies-gut-microbiota-and-metabolic-markers-in-apoe-mice
#8
Nittaya Marungruang, Frida Fåk, Eden Tareke
BACKGROUND: High-fat diet has been known to have adverse effects on metabolic markers, as well as the gut microbiota. However, the effect of heat processing of high-fat diet, which leads to formations of advanced glycation end products (AGEs) has not been clearly distinguished from the effect of unheated fat. This study compared the effect of high-fat diet with heat-treated high-fat diet on adiposity, atherosclerosis and gut microbiota composition in the caecum of apoe (-/-) mice. METHOD: Male apoe (-/-) mice were fed either low-fat (LF) control diet, high-fat (40 E% saturated fat, HF) control diet, or heat-treated high-fat (200 °C for 10 min, HT) diet, for 8 weeks...
2016: Nutrition & Metabolism
https://www.readbyqxmd.com/read/26891260/inhibition-of-interleukin-10-signaling-induces-microbiota-dependent-chronic-colitis-in-apolipoprotein-e-deficient-mice
#9
Vishal Singh, Manish Kumar, Beng San Yeoh, Xia Xiao, Piu Saha, Mary J Kennett, Matam Vijay-Kumar
BACKGROUND: Apolipoprotein E (ApoE) mediates potent antiinflammatory and immunomodulatory properties in addition to its roles in regulating cholesterol transport and metabolism. However, its role in the intestine, specifically during inflammation, is largely unknown. METHODS: Mice (C57BL/6 or ApoE-deficient [ApoE-KO] mice) were administered either single or 4 injections (weekly) of anti-interleukin (IL)-10 receptor monoclonal antibody (1.0 mg/mouse; intraperitoneally) and euthanized 1 week after the last injection...
April 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/26890232/lingonberries-reduce-atherosclerosis-in-apoe-mice-in-association-with-altered-gut-microbiota-composition-and-improved-lipid-profile
#10
Chrysoula Matziouridou, Nittaya Marungruang, Thao Duy Nguyen, Margareta Nyman, Frida Fåk
SCOPE: To investigate the efficacy of lingonberries in prevention of atherosclerosis, using atherosclerosis-prone Apoe(-/-) mice and to clarify whether effects were associated with changes in the gut microbiota, gut metabolites, and lipid metabolism. METHODS AND RESULTS: Male Apoe(-/-) mice were fed either low-fat diet, high-fat diet, or high-fat diet with 44% lingonberries for 8 weeks. Blood lipid profiles, hepatic gene expression, atherosclerotic plaques in the aortic root region of the heart, bacterial 16S rRNA gene profiles, and cecal short-chain fatty acids (SCFAs) were analyzed...
May 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/26799618/modulating-the-gut-microbiota-improves-glucose-tolerance-lipoprotein-profile-and-atherosclerotic-plaque-development-in-apoe-deficient-mice
#11
Ida Rune, Bidda Rolin, Christian Larsen, Dennis Sandris Nielsen, Jenny E Kanter, Karin E Bornfeldt, Jens Lykkesfeldt, Karsten Buschard, Rikke Kaae Kirk, Berit Christoffersen, Johannes Josef Fels, Knud Josefsen, Pernille Kihl, Axel Kornerup Hansen
The importance of the gut microbiota (GM) in disease development has recently received increased attention, and numerous approaches have been made to better understand this important interplay. For example, metabolites derived from the GM have been shown to promote atherosclerosis, the underlying cause of cardiovascular disease (CVD), and to increase CVD risk factors. Popular interest in the role of the intestine in a variety of disease states has now resulted in a significant proportion of individuals without coeliac disease switching to gluten-free diets...
2016: PloS One
https://www.readbyqxmd.com/read/26699388/choline-diet-and-its-gut-microbe-derived-metabolite-trimethylamine-n-oxide-exacerbate-pressure-overload-induced-heart-failure
#12
Chelsea L Organ, Hiroyuki Otsuka, Shashi Bhushan, Zeneng Wang, Jessica Bradley, Rishi Trivedi, David J Polhemus, W H Wilson Tang, Yuping Wu, Stanley L Hazen, David J Lefer
BACKGROUND: Trimethylamine N-oxide (TMAO), a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients, is both elevated in the circulation of patients having heart failure and heralds worse overall prognosis. In animal studies, dietary choline or TMAO significantly accelerates atherosclerotic lesion development in ApoE-deficient mice, and reduction in TMAO levels inhibits atherosclerosis development in the low-density lipoprotein receptor knockout mouse...
January 2016: Circulation. Heart Failure
https://www.readbyqxmd.com/read/26584136/l-carnitine-intake-and-high-trimethylamine-n-oxide-plasma-levels-correlate-with-low-aortic-lesions-in-apoe-transgenic-mice-expressing-cetp
#13
Heidi L Collins, Denise Drazul-Schrader, Anthony C Sulpizio, Paul D Koster, Yuping Williamson, Steven J Adelman, Kevin Owen, Toran Sanli, Aouatef Bellamine
OBJECTIVE: Dietary l-carnitine can be metabolized by intestinal microbiota to trimethylamine, which is absorbed by the gut and further oxidized to trimethylamine N-oxide (TMAO) in the liver. TMAO plasma levels have been associated with atherosclerosis development in ApoE(-/-) mice. To better understand the mechanisms behind this association, we conducted in vitro and in vivo studies looking at the effect of TMAO on different steps of atherosclerotic disease progression. METHODS: J774 mouse macrophage cells were used to evaluate the effect of TMAO on foam cell formation...
January 2016: Atherosclerosis
https://www.readbyqxmd.com/read/26438537/a-novel-transcriptional-regulator-of-l-arabinose-utilization-in-human-gut-bacteria
#14
Changsoo Chang, Christine Tesar, Xiaoqing Li, Youngchang Kim, Dmitry A Rodionov, Andrzej Joachimiak
Carbohydrate metabolism plays a crucial role in the ecophysiology of human gut microbiota. Mechanisms of transcriptional regulation of sugar catabolism in commensal and prevalent human gut bacteria such as Bacteroides thetaiotaomicron remain mostly unknown. By a combination of bioinformatics and experimental approaches, we have identified an NrtR family transcription factor (BT0354 in B. thetaiotaomicron, BtAraR) as a novel regulator controlling the arabinose utilization genes. L-arabinose was confirmed to be a negative effector of BtAraR...
December 2, 2015: Nucleic Acids Research
https://www.readbyqxmd.com/read/25891035/from-the-acta-prize-lecture-2014-the-periodontal-systemic-connection-seen-from-a-microbiological-standpoint
#15
REVIEW
Ingar Olsen
OBJECTIVE: To give an overview of the periodontal-systemic connection seen from a microbiologist. METHODS: Original research papers, review articles and workshop proceedings were consulted. RESULTS: Periodontal bacteria can cross epithelial cells, enter the circulation, invade endothelial cells, induce endothelial cell dysfunction and activate inflammatory and immune responses. Several studies support the association between periodontitis (PD) and cardiovascular disease...
2015: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/25320181/exopolysaccharide-producing-probiotic-lactobacilli-reduce-serum-cholesterol-and-modify-enteric-microbiota-in-apoe-deficient-mice
#16
Lis E E London, Arun H S Kumar, Rebecca Wall, Pat G Casey, Orla O'Sullivan, Fergus Shanahan, Colin Hill, Paul D Cotter, Gerald F Fitzgerald, R Paul Ross, Noel M Caplice, Catherine Stanton
BACKGROUND: Probiotic bacteria have been associated with a reduction in cardiovascular disease risk, a leading cause of death and disability. OBJECTIVES: The aim of this study was to assess the impact of dietary administration of exopolysaccharide-producing probiotic Lactobacillus cultures on lipid metabolism and gut microbiota in apolipoprotein E (apoE)-deficient mice. METHODS: First, we examined lipid metabolism in response to dietary supplementation with recombinant β-glucan-producing Lactobacillus paracasei National Food Biotechnology Centre (NFBC) 338 expressing the glycosyltransferase (Gtf) gene from Pediococcus parvulus 2...
December 2014: Journal of Nutrition
https://www.readbyqxmd.com/read/23747589/lactobacillus-acidophilus-atcc-4356-attenuates-the-atherosclerotic-progression-through-modulation-of-oxidative-stress-and-inflammatory-process
#17
Lihua Chen, Wenen Liu, Yanming Li, San Luo, Qingxia Liu, Yiming Zhong, Zijuan Jian, Meihua Bao
The aim of this study was to investigate the effect of Lactobacillus (L.) acidophilus ATCC 4356 on the progression of atherosclerosis in Apoliprotein-E knockout (ApoE(-/-)) mice and the underlying mechanisms. Eight week-old ApoE(-/-) mice were treated with L. acidophilus ATCC 4356 daily for 12 weeks. The wild type (WT) mice or ApoE(-/-) mice in the vehicle group were treated with saline only. Body weights, serum lipid levels, aortic atherosclerotic lesions, and tissue oxidative and inflammatory statuses were examined among the groups...
September 2013: International Immunopharmacology
https://www.readbyqxmd.com/read/23637607/trypanosome-infection-establishment-in-the-tsetse-fly-gut-is-influenced-by-microbiome-regulated-host-immune-barriers
#18
Brian L Weiss, Jingwen Wang, Michele A Maltz, Yineng Wu, Serap Aksoy
Tsetse flies (Glossina spp.) vector pathogenic African trypanosomes, which cause sleeping sickness in humans and nagana in domesticated animals. Additionally, tsetse harbors 3 maternally transmitted endosymbiotic bacteria that modulate their host's physiology. Tsetse is highly resistant to infection with trypanosomes, and this phenotype depends on multiple physiological factors at the time of challenge. These factors include host age, density of maternally-derived trypanolytic effector molecules present in the gut, and symbiont status during development...
2013: PLoS Pathogens
https://www.readbyqxmd.com/read/23211714/effects-of-probiotic-lactobacillus-rhamnosus-gg-and-propionibacterium-freudenreichii-ssp-shermanii-js-supplementation-on-intestinal-and-systemic-markers-of-inflammation-in-apoe-3leiden-mice-consuming-a-high-fat-diet
#19
Anna Oksaharju, Teake Kooistra, Robert Kleemann, Wim van Duyvenvoorde, Minja Miettinen, Jani Lappalainen, Ken A Lindstedt, Petri T Kovanen, Riitta Korpela, Riina A Kekkonen
A high-fat diet disturbs the composition and function of the gut microbiota and generates local gut-associated and also systemic responses. Intestinal mast cells, for their part, secrete mediators which play a role in the orchestration of physiological and immunological functions of the intestine. Probiotic bacteria, again, help to maintain the homeostasis of the gut microbiota by protecting the gut epithelium and regulating the local immune system. In the present study, we explored the effects of two probiotic bacteria, Lactobacillus rhamnosus GG (GG) and Propionibacterium freudenreichii spp...
July 14, 2013: British Journal of Nutrition
https://www.readbyqxmd.com/read/22821931/gut-microbiota-metabolism-of-anthocyanin-promotes-reverse-cholesterol-transport-in-mice-via-repressing-mirna-10b
#20
Dongliang Wang, Min Xia, Xiao Yan, Dan Li, Lei Wang, Yuxuan Xu, Tianru Jin, Wenhua Ling
RATIONALE: We and others have demonstrated that anthocyanins have antiatherogenic capability. Because intact anthocyanins are absorbed very poorly, the low level of circulating parent anthocyanins may not fully account for their beneficial effect. We found recently that protocatechuic acid (PCA), a metabolite of cyanidin-3 to 0-β-glucoside (Cy-3-G), has a remarkable antiatherogenic effect. OBJECTIVE: To investigate whether mouse gut microbiota metabolizes Cy-3-G into PCA and to determine whether and how PCA contributes to the antiatherogenic potency of its precursor, Cy-3-G...
September 28, 2012: Circulation Research
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