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Apoe microbiota gut

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https://www.readbyqxmd.com/read/29665623/dietary-mannan-oligosaccharides-modulate-gut-microbiota-increase-fecal-bile-acid-excretion-and-decrease-plasma-cholesterol-and-atherosclerosis-development
#1
Lisa R Hoving, Saeed Katiraei, Marieke Heijink, Amanda Pronk, Lianne van der Wee-Pals, Trea Streefland, Martin Giera, Ko Willems van Dijk, Vanessa van Harmelen
SCOPE: Mannan oligosaccharides (MOS) have proven effective at improving growth performance, while also reducing hyperlipidemia and inflammation. As atherosclerosis is accelerated both by hyperlipidemia and inflammation, we aimed to determine the effect of dietary MOS on atherosclerosis development in hyperlipidemic ApoE*3-Leiden.CETP (E3L.CETP) mice, a well-established model for human-like lipoprotein metabolism. METHODS AND RESULTS: Female E3L.CETP mice were fed a high cholesterol diet, with or without 1% MOS for 14 weeks...
April 17, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29615808/long-term-western-diet-fed-apolipoprotein-e-deficient-rats-exhibit-only-modest-early-atherosclerotic-characteristics
#2
Ida Rune, Bidda Rolin, Jens Lykkesfeldt, Dennis Sandris Nielsen, Łukasz Krych, Jenny E Kanter, Karin E Bornfeldt, Pernille Kihl, Karsten Buschard, Knud Josefsen, Johannes Josef Fels, Alan Mortensen, Berit Christoffersen, Rikke Kaae Kirk, Axel Kornerup Hansen
In the apolipoprotein E-deficient mouse, the gut microbiota has an impact on the development of atherosclerosis, but whether such correlations are also present in rats requires investigation. Therefore, we studied female SD-Apoetm1sage (Apoe-/- ) rats fed either a Western diet or a low-fat control diet with or without gluten, which is known to promote gut microbiota changes, until 20 weeks of age. We hypothesized that the manifestation of atherosclerosis would be more severe in Apoe-/- rats fed the Western high-fat diet, as compared with rats fed the low-fat diet, and that atherosclerosis would be accelerated by gluten...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29574035/effects-of-short-term-lead-exposure-on-gut-microbiota-and-hepatic-metabolism-in-adult-zebrafish
#3
Jizhou Xia, Liang Lu, Cuiyuan Jin, Siyu Wang, Jicong Zhou, Yingchun Ni, Zhengwei Fu, Yuanxiang Jin
Lead (Pb) is one of the most prevalent toxic, nonessential heavy metals that has been associated with a wide range of toxic effects in humans and environmental animals. Here, effects of short time exposure to 10 and 30 μg/L Pb on gut microbiota and hepatic metabolism were analyzed in adult male zebrafish. We observed that both 10 and 30 μg/L Pb increased the volume of mucus in the gut. At phylum level, the abundance of α-Proteobacteria decreased significantly and the abundance of Firmicutes increased significantly in the gut when treated with 30 μg/L Pb for 7 days...
March 22, 2018: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29202334/berberine-treatment-increases-akkermansia-in-the-gut-and-improves-high-fat-diet-induced-atherosclerosis-in-apoe-mice
#4
Lin Zhu, Danying Zhang, Hong Zhu, Jimin Zhu, Shuqiang Weng, Ling Dong, Taotao Liu, Yu Hu, Xizhong Shen
BACKGROUND AND AIMS: Gut microbiota plays a major role in metabolic disorders. Berberine is used to treat obesity, diabetes and atherosclerosis. The mechanism underlying the role of berberine in modulating metabolic disorders is not fully clear because berberine has poor oral bioavailability. Thus, we evaluated whether the antiatherosclerotic effect of berberine is related to alterations in gut microbial structure and if so, whether specific bacterial taxa contribute to the beneficial effects of berberine...
January 2018: Atherosclerosis
https://www.readbyqxmd.com/read/28660729/relative-variations-of-gut-microbiota-in-disordered-cholesterol-metabolism-caused-by-high-cholesterol-diet-and-host-genetics
#5
Tao Bo, Shanshan Shao, Dongming Wu, Shaona Niu, Jiajun Zhao, Ling Gao
Recent studies performed provide mechanistic insight into effects of the microbiota on cholesterol metabolism, but less focus was given to how cholesterol impacts the gut microbiota. In this study, ApoE(-/-) Sprague Dawley (SD) rats and their wild-type counterparts (n = 12) were, respectively, allocated for two dietary condition groups (normal chow and high-cholesterol diet). Total 16S rDNA of fecal samples were extracted and sequenced by high-throughput sequencing to determine differences in microbiome composition...
August 2017: MicrobiologyOpen
https://www.readbyqxmd.com/read/28442421/distinct-roles-for-dietary-lipids-and-porphyromonas-gingivalis-infection-on-atherosclerosis-progression-and-the-gut-microbiota
#6
Carolyn D Kramer, Alexandra M Simas, Xianbao He, Robin R Ingalls, Ellen O Weinberg, Caroline Attardo Genco
Mounting evidence in humans supports an etiological role for the microbiota in inflammatory atherosclerosis. Atherosclerosis is a progressive disease characterized by accumulation of inflammatory cells and lipids in vascular tissue. While retention of lipoprotein into the sub-endothelial vascular layer is believed to be the initiating stimulus leading to the development of atherosclerosis, activation of multiple pathways related to vascular inflammation and endothelial dysfunction sustain the process by stimulating recruitment of leukocytes and immune cells into the sub-endothelial layer...
June 2017: Anaerobe
https://www.readbyqxmd.com/read/28377388/targeting-the-gut-microbiota-with-inulin-type-fructans-preclinical-demonstration-of-a-novel-approach-in-the-management-of-endothelial-dysfunction
#7
Emilie Catry, Laure B Bindels, Anne Tailleux, Sophie Lestavel, Audrey M Neyrinck, Jean-François Goossens, Irina Lobysheva, Hubert Plovier, Ahmed Essaghir, Jean-Baptiste Demoulin, Caroline Bouzin, Barbara D Pachikian, Patrice D Cani, Bart Staels, Chantal Dessy, Nathalie M Delzenne
OBJECTIVE: To investigate the beneficial role of prebiotics on endothelial dysfunction, an early key marker of cardiovascular diseases, in an original mouse model linking steatosis and endothelial dysfunction. DESIGN: We examined the contribution of the gut microbiota to vascular dysfunction observed in apolipoprotein E knockout (Apoe-/- ) mice fed an n-3 polyunsaturated fatty acid (PUFA)-depleted diet for 12 weeks with or without inulin-type fructans (ITFs) supplementation for the last 15 days...
February 2018: Gut
https://www.readbyqxmd.com/read/28285599/microbiome-and-metabolome-modifying-effects-of-several-cardiovascular-disease-interventions-in-apo-e-mice
#8
Paul M Ryan, Lis E E London, Trent C Bjorndahl, Rupasri Mandal, Kiera Murphy, Gerald F Fitzgerald, Fergus Shanahan, R Paul Ross, David S Wishart, Noel M Caplice, Catherine Stanton
BACKGROUND: There is strong evidence indicating that gut microbiota have the potential to modify, or be modified by the drugs and nutritional interventions that we rely upon. This study aims to characterize the compositional and functional effects of several nutritional, neutraceutical, and pharmaceutical cardiovascular disease interventions on the gut microbiome, through metagenomic and metabolomic approaches. Apolipoprotein-E-deficient mice were fed for 24 weeks either high-fat/cholesterol diet alone (control, HFC) or high-fat/cholesterol in conjunction with one of three dietary interventions, as follows: plant sterol ester (PSE), oat β-glucan (OBG) and bile salt hydrolase-active Lactobacillus reuteri APC 2587 (BSH), or the drug atorvastatin (STAT)...
March 13, 2017: Microbiome
https://www.readbyqxmd.com/read/28130274/commensal-bacteria-at-the-crossroad-between-cholesterol-homeostasis-and-chronic-inflammation-in-atherosclerosis
#9
Kazuyuki Kasahara, Takeshi Tanoue, Tomoya Yamashita, Keiko Yodoi, Takuya Matsumoto, Takuo Emoto, Taiji Mizoguchi, Tomohiro Hayashi, Naoki Kitano, Naoto Sasaki, Koji Atarashi, Kenya Honda, Ken-Ichi Hirata
The gut microbiota were shown to play critical roles in the development of atherosclerosis, but the detailed mechanism is limited. The purpose of this study is to clarify the influence of gut microbiota on atherogenesis via lipid metabolism and systemic inflammation. Germ-free or conventionally raised (Conv) ApoE-deficient (ApoE(-/-)) mice were fed chow diet and euthanized at 20 weeks of age. We found that the lack of gut microbiota in ApoE(-/-) mice caused a significant increase in the plasma and hepatic cholesterol levels compared with Conv ApoE(-/-) mice...
March 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/27821063/high-fat-diet-induced-atherosclerosis-is-accompanied-with-low-colonic-bacterial-diversity-and-altered-abundances-that-correlates-with-plaque-size-plasma-a-fabp-and-cholesterol-a-pilot-study-of-high-fat-diet-and-its-intervention-with-lactobacillus-rhamnosus
#10
COMPARATIVE STUDY
Yee Kwan Chan, Manreetpal Singh Brar, Pirkka V Kirjavainen, Yan Chen, Jiao Peng, Daxu Li, Frederick Chi-Ching Leung, Hani El-Nezami
BACKGROUND: Atherosclerosis appears to have multifactorial causes - microbial component like lipopolysaccharides (LPS) and other pathogen associated molecular patterns may be plausible factors. The gut microbiota is an ample source of such stimulants, and its dependent metabolites and altered gut metagenome has been an established link to atherosclerosis. In this exploratory pilot study, we aimed to elucidate whether microbial intervention with probiotics L. rhamnosus GG (LGG) or pharmaceuticals telmisartan (TLM) could improve atherosclerosis in a gut microbiota associated manner...
November 8, 2016: BMC Microbiology
https://www.readbyqxmd.com/read/27725195/cardiovascular-health-effects-of-oral-and-pulmonary-exposure-to-multi-walled-carbon-nanotubes-in-apoe-deficient-mice
#11
Daniel V Christophersen, Nicklas R Jacobsen, Maria H G Andersen, Shea P Connell, Kenneth K Barfod, Morten B Thomsen, Mark R Miller, Rodger Duffin, Jens Lykkesfeldt, Ulla Vogel, Håkan Wallin, Steffen Loft, Martin Roursgaard, Peter Møller
Exposure to high aspect ratio nanomaterials, such as multi-walled carbon nanotubes (MWCNTs) may be associated with increased risk of atherosclerosis, pulmonary disease, and cancer. In the present study, we investigated the cardiovascular and pulmonary health effects of 10 weeks of repeated oral or pulmonary exposures to MWCNTs (4 or 40μg each week) in Apolipoprotein E-deficient (ApoE(-/-)) mice fed a Western-type diet. Intratracheal instillation of MWCNTs was associated with oxidative damage to DNA in lung tissue and elevated levels of lipid peroxidation products in plasma, whereas the exposure only caused a modest pulmonary inflammation in terms of increased numbers of lymphocytes in bronchoalveolar lavage fluid...
September 14, 2016: Toxicology
https://www.readbyqxmd.com/read/27696135/acrolein-increases-macrophage-atherogenicity-in-association-with-gut-microbiota-remodeling-in-atherosclerotic-mice-protective-role-for-the-polyphenol-rich-pomegranate-juice
#12
Oren Rom, Hila Korach-Rechtman, Tony Hayek, Yael Danin-Poleg, Haim Bar, Yechezkel Kashi, Michael Aviram
The unsaturated aldehyde acrolein is pro-atherogenic, and the polyphenol-rich pomegranate juice (PJ), known for its anti-oxidative/anti-atherogenic properties, inhibits macrophage foam cell formation, the hallmark feature of early atherosclerosis. This study aimed to investigate two unexplored areas of acrolein atherogenicity: macrophage lipid metabolism and the gut microbiota composition. The protective effects of PJ against acrolein atherogenicity were also evaluated. Atherosclerotic apolipoprotein E-deficient (apoE(-/-)) mice that were fed acrolein (3 mg/kg/day) for 1 month showed significant increases in serum and aortic cholesterol, triglycerides, and lipid peroxides...
April 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/27383250/adaptive-immunity-against-gut-microbiota-enhances-apoe-mediated-immune-regulation-and-reduces-atherosclerosis-and-western-diet-related-inflammation
#13
Diego Saita, Roberto Ferrarese, Chiara Foglieni, Antonio Esposito, Tamara Canu, Laura Perani, Elisa Rita Ceresola, Laura Visconti, Roberto Burioni, Massimo Clementi, Filippo Canducci
Common features of immune-metabolic and inflammatory diseases such as metabolic syndrome, diabetes, obesity and cardiovascular diseases are an altered gut microbiota composition and a systemic pro-inflammatory state. We demonstrate that active immunization against the outer membrane protein of bacteria present in the gut enhances local and systemic immune control via apoE-mediated immune-modulation. Reduction of western-diet-associated inflammation was obtained for more than eighteen weeks after immunization...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27143680/akkermansia-muciniphila-protects-against-atherosclerosis-by-preventing-metabolic-endotoxemia-induced-inflammation-in-apoe-mice
#14
Jin Li, Shaoqiang Lin, Paul M Vanhoutte, Connie W Woo, Aimin Xu
BACKGROUND: Altered composition of the gut microbiota is involved in both the onset and progression of obesity and diabetes mellitus. However, the link between gut microbiota and obesity-related cardiovascular complications has not been explored. The present study was designed to investigate the role of Akkermansia muciniphila, a mucin-degrading bacterium with beneficial effects on metabolism, in the pathogenesis of atherosclerosis in apolipoprotein E-deficient (Apoe(-/-)) mice. METHODS AND RESULTS: Apoe(-/-) mice on normal chow diet or a Western diet were treated with A muciniphila by daily oral gavage for 8 weeks, followed by histological evaluations of atherosclerotic lesion in aorta...
June 14, 2016: Circulation
https://www.readbyqxmd.com/read/27139829/crystal-structure-of-bile-salt-hydrolase-from-lactobacillus-salivarius
#15
Fuzhou Xu, Fangfang Guo, Xiao Jian Hu, Jun Lin
Bile salt hydrolase (BSH) is a gut-bacterial enzyme that negatively influences host fat digestion and energy harvesting. The BSH enzyme activity functions as a gateway reaction in the small intestine by the deconjugation of glycine-conjugated or taurine-conjugated bile acids. Extensive gut-microbiota studies have suggested that BSH is a key mechanistic microbiome target for the development of novel non-antibiotic food additives to improve animal feed production and for the design of new measures to control obesity in humans...
May 2016: Acta Crystallographica. Section F, Structural Biology Communications
https://www.readbyqxmd.com/read/27048804/resveratrol-attenuates-trimethylamine-n-oxide-tmao-induced-atherosclerosis-by-regulating-tmao-synthesis-and-bile-acid-metabolism-via-remodeling-of-the-gut-microbiota
#16
Ming-liang Chen, Long Yi, Yong Zhang, Xi Zhou, Li Ran, Jining Yang, Jun-dong Zhu, Qian-yong Zhang, Man-tian Mi
UNLABELLED: The gut microbiota is found to be strongly associated with atherosclerosis (AS). Resveratrol (RSV) is a natural phytoalexin with anti-AS effects; however, its mechanisms of action remain unclear. Therefore, we sought to determine whether the anti-AS effects of RSV were related to changes in the gut microbiota. We found that RSV attenuated trimethylamine-N-oxide (TMAO)-induced AS in ApoE(-/-) mice. Meanwhile, RSV decreased TMAO levels by inhibiting commensal microbial trimethylamine (TMA) production via gut microbiota remodeling in mice...
April 5, 2016: MBio
https://www.readbyqxmd.com/read/26973703/heat-treated-high-fat-diet-modifies-gut-microbiota-and-metabolic-markers-in-apoe-mice
#17
Nittaya Marungruang, Frida Fåk, Eden Tareke
BACKGROUND: High-fat diet has been known to have adverse effects on metabolic markers, as well as the gut microbiota. However, the effect of heat processing of high-fat diet, which leads to formations of advanced glycation end products (AGEs) has not been clearly distinguished from the effect of unheated fat. This study compared the effect of high-fat diet with heat-treated high-fat diet on adiposity, atherosclerosis and gut microbiota composition in the caecum of apoe (-/-) mice. METHOD: Male apoe (-/-) mice were fed either low-fat (LF) control diet, high-fat (40 E% saturated fat, HF) control diet, or heat-treated high-fat (200 °C for 10 min, HT) diet, for 8 weeks...
2016: Nutrition & Metabolism
https://www.readbyqxmd.com/read/26891260/inhibition-of-interleukin-10-signaling-induces-microbiota-dependent-chronic-colitis-in-apolipoprotein-e-deficient-mice
#18
Vishal Singh, Manish Kumar, Beng San Yeoh, Xia Xiao, Piu Saha, Mary J Kennett, Matam Vijay-Kumar
BACKGROUND: Apolipoprotein E (ApoE) mediates potent antiinflammatory and immunomodulatory properties in addition to its roles in regulating cholesterol transport and metabolism. However, its role in the intestine, specifically during inflammation, is largely unknown. METHODS: Mice (C57BL/6 or ApoE-deficient [ApoE-KO] mice) were administered either single or 4 injections (weekly) of anti-interleukin (IL)-10 receptor monoclonal antibody (1.0 mg/mouse; intraperitoneally) and euthanized 1 week after the last injection...
April 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/26890232/lingonberries-reduce-atherosclerosis-in-apoe-mice-in-association-with-altered-gut-microbiota-composition-and-improved-lipid-profile
#19
Chrysoula Matziouridou, Nittaya Marungruang, Thao Duy Nguyen, Margareta Nyman, Frida Fåk
SCOPE: To investigate the efficacy of lingonberries in prevention of atherosclerosis, using atherosclerosis-prone Apoe(-/-) mice and to clarify whether effects were associated with changes in the gut microbiota, gut metabolites, and lipid metabolism. METHODS AND RESULTS: Male Apoe(-/-) mice were fed either low-fat diet, high-fat diet, or high-fat diet with 44% lingonberries for 8 weeks. Blood lipid profiles, hepatic gene expression, atherosclerotic plaques in the aortic root region of the heart, bacterial 16S rRNA gene profiles, and cecal short-chain fatty acids (SCFAs) were analyzed...
May 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/26799618/modulating-the-gut-microbiota-improves-glucose-tolerance-lipoprotein-profile-and-atherosclerotic-plaque-development-in-apoe-deficient-mice
#20
Ida Rune, Bidda Rolin, Christian Larsen, Dennis Sandris Nielsen, Jenny E Kanter, Karin E Bornfeldt, Jens Lykkesfeldt, Karsten Buschard, Rikke Kaae Kirk, Berit Christoffersen, Johannes Josef Fels, Knud Josefsen, Pernille Kihl, Axel Kornerup Hansen
The importance of the gut microbiota (GM) in disease development has recently received increased attention, and numerous approaches have been made to better understand this important interplay. For example, metabolites derived from the GM have been shown to promote atherosclerosis, the underlying cause of cardiovascular disease (CVD), and to increase CVD risk factors. Popular interest in the role of the intestine in a variety of disease states has now resulted in a significant proportion of individuals without coeliac disease switching to gluten-free diets...
2016: PloS One
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