Candace Chang, Rajat Gupta, Farzaneh Sedighian, Allen Louie, David Gonzalez, Collin Le, Jae Min Cho, Seul-Ki Park, Jocelyn Castellanos, To-Wei Ting, Tien S Dong, Nerea Arias-Jayo, Venu Lagishetty, Mohamad Navab, Srinivasa Reddy, Constantinos Sioutas, Tzung Hsiai, Jonathan P Jacobs, Jesus A Araujo
Exposure to ultrafine particles (UFPs) has been associated with multiple adverse health effects. Inhaled UFPs could reach the gastrointestinal tract and influence the composition of the gut microbiome. We have previously shown that oral ingestion of UFPs alters the gut microbiome and promotes intestinal inflammation in hyperlipidemic Ldlr-/- mice. Particulate matter (PM)2.5 inhalation studies have also demonstrated microbiome shifts in normolipidemic C57BL/6 mice. However, it is not known whether changes in microbiome precede or follow inflammatory effects in the intestinal mucosa...
January 17, 2024: Environmental Research