keyword
MENU ▼
Read by QxMD icon Read
search

Safety surveillance

keyword
https://www.readbyqxmd.com/read/29784457/the-dynamic-role-of-dengue-cross-reactive-immunity-changing-the-approach-to-defining-vaccine-safety-and-efficacy
#1
REVIEW
Kathryn B Anderson, Timothy P Endy, Stephen J Thomas
Dengue virus infections cause a substantial public health burden in tropical and subtropical regions. A single dengue vaccine has been approved by regulatory authorities in 19 countries, but concerns regarding vaccine safety in people who are dengue naive at the time of immunisation has introduced uncertainty into the vaccine's future. As other dengue vaccines complete or enter large-scale efficacy trials, we argue that foundational work by Sabin, historic epidemiological observations of dengue outbreaks, and prospective cohort studies in Asia and the Americas indicate that modifications must be made to the methods of assessing dengue vaccines...
May 18, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29783793/summary-of-u-s-injuries-and-fatalities-involving-entrapment-and-suffocation-in-grain-transport-vehicles
#2
Yuan-Hsin Cheng, William E Field, Salah F Issa, Kevin Kelley, Matthew Heber, Robert Turner
Since 1978, the Purdue University Agricultural Safety and Health Program has managed a surveillance effort and database to collect information on documented injuries and fatalities in all forms of U.S. agricultural confined spaces. The database currently contains 1,968 cases documented in the U.S. between 1964 and 2016. Of these cases, 174 (8.8%) involved entrapment or suffocation in grain transport vehicles (GTVs), including gravity-flow wagons, semi-truck trailers, and other agricultural transport vehicles that have limited access and are not considered normal work spaces or are classified as confined spaces...
May 7, 2018: Journal of Agricultural Safety and Health
https://www.readbyqxmd.com/read/29781981/national-patient-safety-program-in-brazil-incidents-reported-between-2014-and-2017
#3
Tássia Nery Faustino, Edenise Maria Santos da Silva Batalha, Silvana Lima Vieira, Andressa Garcia Nicole, Alexandre Souza Morais, Daisy Maria Rizatto Tronchin, Marta Maria Melleiro
OBJECTIVE: The aim of the study was to analyze the patient safety incidents reported to the Brazilian National Health Surveillance System from March 2014 to March 2017. METHOD: A documentary study that used the records of the incidents published in the Reports of Adverse Events (AE) in Brazil. The following variables were selected: number of incidents by type, type of health service, hospital unit, and degree of harm. To find whether there was a significant difference across the Brazilian regions by notifications related to general incidents, AE, and deaths, the analysis of variance and the Tukey tests were used...
May 16, 2018: Journal of Patient Safety
https://www.readbyqxmd.com/read/29777520/relationship-of-eating-patterns-and-metabolic-parameters-and-teneligliptin-treatment-interim-results-from-post-marketing-surveillance-in-japanese-type-2-diabetes-patients
#4
Takashi Kadowaki, Masakazu Haneda, Hiroshi Ito, Kazuyo Sasaki, Sonoe Hiraide, Miyuki Matsukawa, Makoto Ueno
INTRODUCTION: Healthy eating is a critical aspect of the prevention and management of type 2 diabetes (T2DM). Disrupted eating patterns can result in poor glucose control and increase the likelihood of diabetic complications. Teneligliptin inhibits dipeptidyl peptidase-4 activity for 24 h and suppresses postprandial hyperglycemia after all three daily meals. This interim analysis of data from the large-scale post-marketing surveillance of teneligliptin (RUBY) in Japan examined eating patterns and their relationship with metabolic parameters and diabetic complications...
May 17, 2018: Advances in Therapy
https://www.readbyqxmd.com/read/29776848/comparison-of-current-methods-used-to-detect-cryptosporidium-oocysts-in-stools
#5
REVIEW
Shahira A Ahmed, Panagiotis Karanis
In this review all of the methods that are currently in use for the investigation of Cryptosporidium in stool material are highlighted and critically discussed. It appears that more qualifications and background knowledge in this field regarding the diagnosis of the Cryptosporidium parasite is required. Furthermore, there is no standardization for the protocols that are commonly used to either detect oocysts in faeces or to diagnose the Cryptosporidium infection. It is therefore necessary to initiate further education and research that will assist in improving the accuracy of the diagnosis of Cryptosporidium oocysts in the faecal micro-cosmos...
April 21, 2018: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/29770080/public-health-surveillance-for-the-toronto-2015-pan-parapan-american-games
#6
E Chan, K Hohenadel, B Lee, M Helferty, J R Harris, L Macdonald, T Badiani
Background: Public health surveillance for previous Olympic and Paralympic Games have been described in the literature, but surveillance for regional, multisport events on a smaller scale have rarely been explored. Objective: To describe the public health surveillance planning, implementation, results, and lessons learned from the 2015 Pan/Parapan American Games in Toronto, Ontario, Canada. Intervention: Public health surveillance planning for the Games began two years in advance and involved local, provincial and federal partners, primarily focusing on infectious disease...
July 6, 2017: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29770052/surveillance-of-laboratory-exposures-to-human-pathogens-and-toxins-canada-2016
#7
A Bienek, M Heisz, M Su
Background: Canada recently enacted legislation to authorize the collection of data on laboratory incidents involving a biological agent. This is done by the Public Health Agency of Canada (PHAC) as part of a comprehensive national program that protects Canadians from the health and safety risks posed by human and terrestrial animal pathogens and toxins. Objective: To describe the first year of data on laboratory exposure incidents and/or laboratory-acquired infections in Canada since the Human Pathogens and Toxins Regulations came into effect...
November 2, 2017: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29769275/-point-counterpoint-active-surveillance-for-carriers-of-toxigenic-clostridium-difficile-should-be-performed-to-guide-prevention-efforts
#8
L Clifford McDonald, Daniel J Diekema
In 2017, we published a point-counterpoint on laboratory diagnosis of C. difficile infection (CDI). At that time, Drs Ferric Fang, Christopher Polage, and Mark Wilcox discussed the strategies for diagnosing Clostridium difficile colitis in symptomatic patients. Since that manuscript new guidelines from the Infectious Diseases Society of American and the Society for Health Care Epidemiology have been published (1) and healthcare systems have begun to explore screening asymptomatic patients for C. difficile colonization...
May 16, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29761281/characteristics-quality-and-contribution-to-signal-detection-of-spontaneous-reports-of-adverse-drug-reactions-via-the-web-radr-mobile-application-a-descriptive-cross-sectional-study
#9
Ingrid Oosterhuis, Henric Taavola, Philip M Tregunno, Petar Mas, Sara Gama, Victoria Newbould, Ola Caster, Linda Härmark
INTRODUCTION: Spontaneous reporting of suspected adverse drug reactions is key for efficient post-marketing safety surveillance. To increase usability and accessibility of reporting tools, the Web-Recognising Adverse Drug Reactions (WEB-RADR) consortium developed a smartphone application (app) based on a simplified reporting form. OBJECTIVE: The objective of this study was to evaluate the characteristics, quality and contribution to signals of reports submitted via the WEB-RADR app...
May 14, 2018: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/29757886/perioperative-lidocaine-infusions-for-the-prevention-of-chronic-post-surgical-pain-a-systematic-review-and-meta-analysis-of-efficacy-and-safety
#10
Martin Bailey, Tomas Corcoran, Stephan Schug, Andrew Toner
Chronic post-surgical pain (CPSP) occurs in 12% of surgical populations and is a high priority for perioperative research. Systemic lidocaine may modulate several of the pathophysiological processes linked to CPSP. This systematic review aims to identify and synthesize the evidence linking lidocaine infusions and CPSP.The authors conducted a systematic literature search of the major medical databases from inception until October 2017. Trials that randomized adults without baseline pain to perioperative lidocaine infusion or placebo were included if they reported on CPSP...
May 11, 2018: Pain
https://www.readbyqxmd.com/read/29757672/enzyme-based-ultrasensitive-electrochemical-biosensors-for-rapid-assessment-of-nitrite-toxicity-recent-advances-and-perspectives
#11
Anjum Gahlaut, Vinita Hooda, Ashish Gothwal, Vikas Hooda
In the present era of rapid international globalization and industrialization, intensive use of nitrite as a fertilizing agent in agriculture, preservative, dyeing agent, food additive and as corrosion inhibitor in industrial sectors is adversely effecting environment, natural habitats and human health. The issue of toxicity and carcinogenicity due to excessive ingestion of nitrites via the dietary intake has led to an imminent need for its efficient real-time monitoring in situ. Nitrite detection employing electrochemical biosensors has been gaining high credibility in the field of clinical research...
May 14, 2018: Critical Reviews in Analytical Chemistry
https://www.readbyqxmd.com/read/29757363/targeting-endothelial-ligands-icam-1-alicaforsen-madcam-1
#12
Walter Reinisch, Kenneth Hung, Mina Hassan-Zahraee, Fabio Cataldi
The specific blockade of the endothelial ligands intercellular adhesion molecule-1 (ICAM-1) and mucosal addressin cell adhesion molecule (MAdCAM) involved in leukocyte recruitment to the site of inflammation as therapeutic targets in inflammatory bowel disease (IBD) has been recognized from their overexpression in the inflamed mucosa and their successful intervention in preclinical animal models. Interventions to target ICAM-1 in human IBD are confined to the ICAM-1 anti-sense oligonucleotide alicaforsen. Whereas results with parenteral formulations of alicaforsen in Crohn's disease were largely negative, efficacy signals derived from studies with an enema formulation in ulcerative and pouchitis are promising and having lead to a FDA Fast-Track designation for the latter...
May 11, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29754209/activity-of-ertapenem-against-enterobacteriaceae-in-seven-global-regions-smart-2012-2016
#13
Sibylle H Lob, Meredith A Hackel, Daryl J Hoban, Katherine Young, Mary R Motyl, Daniel F Sahm
Antimicrobial resistance among Enterobacteriaceae has been increasing globally especially due to extended-spectrum-β-lactamases (ESBLs), which typically necessitate the use of carbapenems for treatment of serious infections. Emerging carbapenem-resistant Enterobacteriaceae further complicate therapy. As part of the Study for Monitoring Antimicrobial Resistance Trends (SMART), this analysis examined the recent activity of a key carbapenem (ertapenem) and other important therapeutic options against Enterobacteriaceae...
May 12, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29752026/safety-of-a-heat-stable-rotavirus-vaccine-among-children-in-niger-data-from-a-phase-3-randomized-double-blind-placebo-controlled-trial
#14
Matthew E Coldiron, Ousmane Guindo, Rockyath Makarimi, Issaka Soumana, Amadou Matar Seck, Souna Garba, Emilie Macher, Sheila Isanaka, Rebecca F Grais
BACKGROUND: Rotavirus remains a major cause of diarrhea among children under 5 years of age. The efficacy of RotaSIIL, a pentavalent rotavirus vaccine, was shown in an event-driven trial in Niger. We describe the two-year safety follow-up of this trial. METHODS: Follow-up of safety outcomes began upon administration of the first dose of RotaSIIL or placebo. Adverse events were followed until 28 days after the third dose, and serious adverse events were followed until 2 years of age...
May 8, 2018: Vaccine
https://www.readbyqxmd.com/read/29751587/pcbs-and-pcdd-fs-in-bluefin-tuna-occurrence-and-dietary-intake
#15
Grazia Barone, Arianna Storelli, Rita Garofalo, Rosanna Mallamaci, Nicoletta C Quaglia, Maria Maddalena Storelli
Polychlorinated biphenyls (PCBs) and polychlorinated dibenzo-furans (PCDD/Fs) were measured in Mediterranean bluefin tuna ( Thunnus thynnus ) to verify the compliance with the EU regulations for food commercialization. The estimated intakes were also evaluated. The analyses were performed by gas chromatography-ion trap tandem mass spectrometry (GC-MS-MS). The PCBs were dominant (1132.0 ng g−1 l.w.), followed by PCDFs (23.2 pg g−1 l.w.) and PCDDs (8.5 pg g−1 l.w.). The pollutant levels (dl-PCBs: 0...
May 3, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29749086/imposed-registries-within-the-european-postmarketing-surveillance-system-extended-analysis-and-lessons-learned-for-regulators
#16
Alexandra Pacurariu, Kelly Plueschke, Carla Alonso Olmo, Xavier Kurz
PURPOSE: Building on previous research, we examined whether delayed study start and low patient accrual rates found in 31 postauthorization registry-based studies requested by European Medicines Agency (EMA) are maintained after 2 additional years of follow-up. METHOD: The registries identified in the previous EMA study and the same methodology were used. The follow-up was extended from June 2015 to November 2017. The information available for the following variables was updated: marketing authorization status, study and registry status, study end date, planned duration, number of patients planned to be enrolled, and actual patients enrolled...
May 11, 2018: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29748940/surveillance-of-adverse-events-following-immunization-in-oman-2006-2015
#17
Prakash K Patel, Bader Al-Rawahi, Athari Al-Jawari, Idris Al-Abaidani, Seif Al-Abri
Background: In 1996, Oman launched its surveillance programme for adverse events following immunization (AEFI) to address vaccine safety concerns. In 2010, an analysis of surveillance activities for AEFI was done for 10 years (1996-2005). Objectives: The main objective of the study was to describe the trend of AEFI over the 10-year period, 2006-2015, and compare the findings with a previous report in Oman and reports from other countries. Methods: A descriptive record-based review of AEFI was carried out using the national AEFI surveillance database for the study period, 2006-2015...
May 3, 2018: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
https://www.readbyqxmd.com/read/29746978/clinical-studies-of-the-effectiveness-and-safety-of-antivenoms
#18
David J Williams, Abdulrazaq G Habib, David A Warrell
In the 1890s, hyperimmune sera proved effective in animals against challenge by the snake venom against which they had been raised. They were first used, apparently successfully, in a human patient in about 1895. Since then, antivenoms have become accepted as the only reliable specific treatment for snake-bite envenoming. Despite decades of accumulated clinical experience and a number of published randomised comparative and observational studies, the clinical effectiveness and safety of some antivenoms remain open to question, due to a lack of robust randomised controlled trial data...
May 7, 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29746444/role-of-letermovir-for-prevention-of-cytomegalovirus-infection-after-allogeneic-haematopoietic-stem-cell-transplantation
#19
Raymund R Razonable
PURPOSE OF REVIEW: Cytomegalovirus (CMV) infection is a common opportunistic infection after allogeneic haematopoietic stem cell transplantation (HSCT). CMV surveillance-preemptive therapy is the current preferred approach for preventing CMV disease after HSCT. In contrast, antiviral prophylaxis is not commonly used due to myelosuppressive effects of valganciclovir. In this article, the role of the newly approved antiviral compound, letermovir, is reviewed. RECENT FINDINGS: Letermovir inhibits CMV by interfering viral terminase complex...
May 8, 2018: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/29746338/oncological-and-survival-outcomes-in-watch-and-wait-patients-with-a-clinical-complete-response-after-neoadjuvant-chemoradiotherapy-for-rectal-cancer-a-systematic-review-and-pooled-analysis
#20
Mit Dattani, Richard J Heald, Ghaleb Goussous, Jack Broadhurst, Guilherme P São Julião, Angelita Habr-Gama, Rodrigo Oliva Perez, Brendan J Moran
OBJECTIVE: The aim of this study was to evaluate the oncological and survival outcomes of a Watch and Wait policy in rectal cancer after a clinical complete response (cCR) following neoadjuvant chemoradiotherapy. BACKGROUND: The detection of a cCR after neoadjuvant treatment may facilitate a nonoperative approach in selected patients. However, the long-term safety of this strategy remains to be validated. METHOD: This is a systematic review of the literature to determine the oncological outcomes in Watch and Wait patients...
May 9, 2018: Annals of Surgery
keyword
keyword
87441
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"