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https://www.readbyqxmd.com/read/29324212/managing-patients-with-oligometastatic-non-small-cell-lung-cancer
#1
Sarah Jo Stephens, Michael J Moravan, Joseph K Salama
Metastatic lung cancer has long been considered incurable, with the goal of treatment being palliation. However, a clinically meaningful number of these patients with limited metastases (approximately 25%) are living long term after definitive treatment to all sites of active disease. These patients with so-called oligometastatic disease likely represent a distinct clinical group who may possess a more indolent biology compared with their more widely metastatic counterparts. Hellman and Weichselbaum proposed the existence of the oligometastatic state, on the basis of the spectrum theory of cancer spread...
January 2018: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29296920/identification-of-a-murine-cd45-f4-80lo-hsc-derived-marrow-endosteal-cell-associated-with-donor-stem-cell-engraftment
#2
Kathleen M Overholt, Satoru Otsuru, Timothy S Olson, Adam J Guess, Victoria M Velazquez, Laura Desbourdes, Massimo Dominici, Edwin M Horwitz
Hematopoietic stem cells (HSCs) reside in specialized microenvironments within the marrow designated as stem cell niches, which function to support HSCs at homeostasis and promote HSC engraftment after radioablation. We previously identified marrow space remodeling after hematopoietic ablation, including osteoblast thickening, osteoblast proliferation, and megakaryocyte migration to the endosteum, which is critical for effective engraftment of donor HSCs. To further evaluate the impact of hematopoietic cells on marrow remodeling, we used a transgenic mouse model (CD45Cre/iDTR) to selectively deplete hematopoietic cells in situ...
December 26, 2017: Blood Advances
https://www.readbyqxmd.com/read/29283687/recall-erythema-phenomenon-following-er-yag-laser-treatment-two-case-studies-and-literature-review
#3
Margit L W Juhász, Melissa Kanchanapoomi Levin, Ellen S Marmur
Recall erythema is a phenomenon occurring when an area of epidermis treated with laser is later exposed to a trigger, most often sunlight or hot water, causing erythema in the zone of laser treatment after post-treatment erythema has already resolved. Radiation recall dermatitis is a more specific subtype of recall erythema in which an area treated with radiation is subjected to another exposure causing erythema in the area of previous radiation. Cases of recall dermatitis after laser treatment are extremely rare and have only been reported with diode neodymium-doped yttrium aluminum garnet lasers...
December 28, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29236642/noninvasive-cardiac-radiation-for-ablation-of-ventricular-tachycardia
#4
Phillip S Cuculich, Matthew R Schill, Rojano Kashani, Sasa Mutic, Adam Lang, Daniel Cooper, Mitchell Faddis, Marye Gleva, Amit Noheria, Timothy W Smith, Dennis Hallahan, Yoram Rudy, Clifford G Robinson
BACKGROUND: Recent advances have enabled noninvasive mapping of cardiac arrhythmias with electrocardiographic imaging and noninvasive delivery of precise ablative radiation with stereotactic body radiation therapy (SBRT). We combined these techniques to perform catheter-free, electrophysiology-guided, noninvasive cardiac radioablation for ventricular tachycardia. METHODS: We targeted arrhythmogenic scar regions by combining anatomical imaging with noninvasive electrocardiographic imaging during ventricular tachycardia that was induced by means of an implantable cardioverter-defibrillator (ICD)...
December 14, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29079566/swine-atrioventricular-node-ablation-using-stereotactic-radiosurgery-methods-and-in-vivo-feasibility-investigation-for-catheter-free-ablation-of-cardiac-arrhythmias
#5
Marwan M Refaat, Jad A Ballout, Patrick Zakka, Mostafa Hotait, Karine A Al Feghali, Ibrahim Abu Gheida, Charbel Saade, Mukbil Hourani, Fady Geara, Malek Tabbal, Pierre Sfeir, Wassim Jalbout, Wael Al-Jaroudi, Abdo Jurjus, Bassem Youssef
BACKGROUND: Linear accelerator-based stereotactic radiosurgery delivered to cardiac arrhythmogenic foci could be a promising catheter-free ablation modality. We tested the feasibility of in vivo atrioventricular (AV) node ablation in swine using stereotactic radiosurgery. METHODS AND RESULTS: Five Large White breed swine (weight 40-75 kg; 4 females) were studied. Single-chamber St Jude pacemakers were implanted in each pig. The pigs were placed under general anesthesia, and coronary/cardiac computed tomography simulation scans were performed to localize the AV node...
October 27, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28752279/ablative-radiotherapy-as-a-noninvasive-alternative-to-catheter-ablation-for-cardiac-arrhythmias
#6
REVIEW
Paul C Zei, Scott Soltys
PURPOSE OF REVIEW: Stereotactic radioablation is a commonly utilized technology to noninvasively treat solid tumors with precision and efficacy. Using a robotic arm mounted delivery system, multiple low-dose ionizing radiation beams are delivered from multiple angles, concentrating ablative energy at the target tissue. Recently, this technology has been evaluated for treatment of cardiac arrhythmias. This review will present the basic underlying principles, proof-of-principle studies, and clinical experience with stereotactic arrhythmia radioablation...
September 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/28545199/cyberknife-radioablation-of-prostate-cancer-%C3%A2-preliminary-results-for-400-patients
#7
Leszek Miszczyk, Agnieszka Namysł Kaletka, Aleksandra Napieralska, Grzegorz Woźniak, Małgorzata Stąpór Fudzińska, Grzegorz Głowacki, Andrzej Tukiendorf
Objectives: To evaluate the tolerance and effectiveness of stereotactic ablative radiotherapy (SABR) applied in the treatment of low and intermediate risk (LR & IR) prostate cancer patients (PCP) and provide an evaluation of the level of risk group impact on treatment results. In addition, androgen deprivation therapy (ADT) usage and prostatic specific antigen (PSA) decline after SABR were assessed. Material and Methods: A total of 400 PCP (213 LR and 187 IR, including T2c) were irradiated with a CyberKnife using fd 7...
April 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28539216/cost-effectiveness-of-using-recombinant-human-thyroid-stimulating-hormone-before-radioiodine-ablation-for-thyroid-cancer-treatment-in-spanish-hospitals
#8
J A Vallejo, M A Muros
OBJECTIVES: In thyroid cancer treatment, the thyroid-stimulating hormone (TSH) must be elevated before radioiodine ablation, either by exogenous (with recombinant human thyrotropin [rhTSH]) or endogenous stimulation by thyroid hormone withdrawal (THW). The use of rhTSH avoids hypothyroidism and favours the subsequent elimination of radioiodine, but involves the cost of the product. For this reason, a cost-effectiveness analysis was performed, taking into account all costs involved and the benefits associated with the use of this therapy...
November 2017: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/28475423/investigating-the-abscopal-effects-of-radioablation-on-shielded-bone-marrow-in-rodent-models-using-multimodality-imaging
#9
Solmaz F Afshar, Janice A Zawaski, Taeko Inoue, David A Rendon, Arthur W Zieske, Jyotinder N Punia, Omaima M Sabek, M Waleed Gaber
The abscopal effect is the response to radiation at sites that are distant from the irradiated site of an organism, and it is thought to play a role in bone marrow (BM) recovery by initiating responses in the unirradiated bone marrow. Understanding the mechanism of this effect has applications in treating BM failure (BMF) and BM transplantation (BMT), and improving survival of nuclear disaster victims. Here, we investigated the use of multimodality imaging as a translational tool to longitudinally assess bone marrow recovery...
July 2017: Radiation Research
https://www.readbyqxmd.com/read/28464838/primary-extragenital-endometrial-stromal-sarcoma-of-the-lung-first-reported-case-and-review-of-literature
#10
Lara Alessandrini, Francesco Sopracordevole, Giulio Bertola, Simona Scalone, Martina Urbani, Gianmaria Miolo, Tiziana Perin, Fabrizio Italia, Vincenzo Canzonieri
BACKGROUND: Endometrial stromal sarcomas arising in extrauterine and extraovarian sites, in the absence of a primary uterine lesion are quite rare, especially in the absence of endometriosis. They usually present as an abdominal or pelvic mass lesion. CASE PRESENTATION: In 2007, a 45-year-old woman underwent total hysterectomy for in situ squamous cell carcinoma of the cervix. In 2014, an upper left pulmonary lobectomy was performed for a mass, which was provisionally diagnosed as primary carcinosarcoma of the lung...
May 2, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/28457178/postoperative-outcomes-in-graves-disease-patients-results-from-the-nationwide-inpatient-sample-database
#11
Gustavo A Rubio, Tulay Koru-Sengul, Tanaz M Vaghaiwalla, Punam P Parikh, Josefina C Farra, John I Lew
BACKGROUND: Current surgical indications for Graves' disease include intractability to medical and/or radioablative therapy, compressive symptoms, and worsening ophthalmopathy. Total thyroidectomy for Graves' disease may be technically challenging and lead to untoward perioperative outcomes. This study examines outcomes in patients with Graves' disease who underwent total thyroidectomy and assesses its safety for this patient population. METHODS: A retrospective cross-sectional analysis was performed using the Nationwide Inpatient Sample database from 2006 to 2011...
June 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28341865/radioablation-of-adrenal-gland-malignomas-with-interstitial-high-dose-rate-brachytherapy-efficacy-and-outcome
#12
K Mohnike, K Neumann, P Hass, M Seidensticker, R Seidensticker, M Pech, S Klose, T Streitparth, B Garlipp, C Benckert, J J Wendler, U B Liehr, M Schostak, D Göppner, G Gademann, J Ricke
PURPOSE: To assess the efficacy, safety, and outcome of image-guided high-dose-rate (HDR) brachytherapy in patients with adrenal gland metastases (AGM). MATERIALS AND METHODS: From January 2007 to April 2014, 37 patients (7 female, 30 male; mean age 66.8 years, range 41.5-82.5 years) with AGM from different primary tumors were treated with CT-guided HDR interstitial brachytherapy (iBT). Primary endpoint was local tumor control (LTC). Secondary endpoints were time to untreatable progression (TTUP), time to progression (TTP), overall survival (OS), and safety...
August 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28250160/glucose-dependent-insulinotropic-polypeptide-receptor-deficiency-leads-to-impaired-bone-marrow-hematopoiesis
#13
Fernanda Dana Mantelmacher, Sigal Fishman, Keren Cohen, Metsada Pasmanik Chor, Yuichiro Yamada, Isabel Zvibel, Chen Varol
The bone marrow (BM) contains controlled specialized microenvironments, or niches, that regulate the quiescence, proliferation, and differentiation of hematopoietic stem and progenitor cells (HSPC). The glucose-dependent insulinotropic polypeptide (GIP) is a gut-derived incretin hormone that mediates postprandial insulin secretion and has anabolic effects on adipose tissue. Previous studies demonstrated altered bone microarchitecture in mice deficient for GIP receptor (Gipr(-/-) ), as well as the expression of high-affinity GIP receptor by distinct cells constructing the BM HSPC niche...
April 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27794246/incidental-papillary-thyroid-carcinoma-in-thyroglossal-duct-cyst-case-report
#14
Ana Karen Lira Medina, Eliseo Fernandez Berdeal, Ernesto Bernal Cisneros, Rebeca Betancourt Galindo, Pamela Frigerio
INTRODUCTION: The thyroglossal cyst is found in 7% of the population and the incidental papillary thyroid carcinoma in thyroglossal cyst is a rare entity with an incidence 1 to 2%. The clinical presentation is indistinguishable from a benign lesion and the histopathological postoperative study defines the diagnosis. Papillary carcinomas have favorable prognosis and cervical or distant metastases are rare. There is now a consensus on the indication of total thyroidectomy, radioablation with iodine and/or suppressive therapy with levothyroxine after being removed surgically [1-3] (Patrucco et al...
2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27730067/antithyroid-drugs-in-graves-disease-are-we-stretching-it-too-far
#15
Muthukrishnan Jayaraman, Anil Kumar Pawah, C S Narayanan
INTRODUCTION: Early and durable achievement of euthyroid or hypothyroid status with low likelihood of relapse is the key to effective treatment of Graves' disease (GD). Although antithyroid drugs (ATDs) are commonly used first-line agents, likelihood of remission remains highest with radioactive iodine (RAI) therapy and surgery. Data regarding efficacy and economical superiority of RAI therapy over ATDs are lacking from India. This study was designed to study the response to long-term (>12 months) use of ATDs in GD with respect to attainment of remission and to compare the cost of treatment with ATDs versus RAI therapy beyond 12 months...
September 2016: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27674237/intermediate-risk-prostate-cancer-treated-with-3-radioablative-regimens-comparison-of-robotic-ultrahypofractionation-and-high-dose-rate-brachytherapy-alone-or-combined-with-external-beam-radiation-therapy
#16
P A Wojcieszek, M Szlag, G Glowacki, A Cholewka, M Fijalkowski, S Kellas, B Biala, L Miszczyk
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27588323/rate-of-elimination-of-radioiodine-avid-lymph-node-metastases-of-differentiated-thyroid-carcinoma-by-postsurgical-radioiodine-ablation-a-bicentric-study
#17
MULTICENTER STUDY
Harun Ilhan, Mona Mustafa, Peter Bartenstein, Torsten Kuwert, Daniela Schmidt
SPECT/CT detects radioiodine-positive cervical lymph node metastases (LNMs) of differentiated thyroid carcinoma (DTC) at the time of postsurgical radioablation (RA). Preliminary evidence indicates that the majority of LNMs are successfully treated by RA. The aim of this study was to confirm this evidence in a bicentric setting and to evaluate whether size is a predictor for successful elimination. PATIENTS AND METHODS: Since 01/2007 and 05/2008, respectively, SPECT/spiral-CT is performed routinely in all patients with DTC at RA in two University Clinics...
December 6, 2016: Nuklearmedizin. Nuclear Medicine
https://www.readbyqxmd.com/read/27570715/stereotactic-arrhythmia-radioablation-star-of-ventricular-tachycardia-a-treatment-planning-study
#18
Lei Wang, Benjamin Fahimian, Scott G Soltys, Paul Zei, Anthony Lo, Edward A Gardner, Patrick J Maguire, Billy W Loo
PURPOSE: The first stereotactic arrhythmia radioablation (STAR) of ventricular tachycardia (VT) was delivered at Stanford on a robotic radiosurgery system (CyberKnife® G4) in 2012. The results warranted further investigation of this treatment. Here we compare dosimetrically three possible treatment delivery platforms for STAR. METHODS: The anatomy and target volume of the first treated patient were used for this study. A dose of 25 Gy in one fraction was prescribed to the planning target volume (PTV)...
July 15, 2016: Curēus
https://www.readbyqxmd.com/read/27340576/recurrent-thyrotoxicosis-due-to-both-graves-disease-and-hashimoto-s-thyroiditis-in-the-same-three-patients
#19
Ashley Schaffer, Vidya Puthenpura, Ian Marshall
Hashimoto's thyroiditis (HT) and Graves' disease (GD) are the 2 most common autoimmune disease processes affecting the thyroid gland. The relationship between the two is complex and not clearly understood. It has been theorized that HT and GD are 2 separate disease processes due to unique genetic differences demonstrated by genome studies. On the other hand, based on occurrence of both HT and GD in monozygotic twins and within the same family, they have been regarded to represent 2 ends of the same spectrum...
2016: Case Reports in Endocrinology
https://www.readbyqxmd.com/read/27179574/thyroid-stimulating-hormone-acutely-increases-monocyte-gene-expression-in-vivo
#20
AnneMarie Gagnon, Heather A Lochnan, Christopher S Tran, Alexander Sorisky
OBJECTIVES: Thyroid-stimulating hormone (TSH) acts in an extra-thyroidal fashion and induces a pro-inflammatory, pro-coagulant state. Blood monocytes can be activated by vascular stress, but it is not known if this occurs upon TSH administration. Our aim was to determine if recombinant human (rh) TSH, administered acutely to patients being screened for thyroid cancer recurrence, alters blood monocyte gene expression. DESIGN AND SETTING: Patients (14 women, 1 man) had a mean (±SD) age of 48±10 years, a body mass index of 26±6 kg/m2, a history of total thyroidectomy and radioablation for thyroid cancer, and were on L-thyroxine therapy at a university teaching hospital...
2016: Neuro Endocrinology Letters
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