Abdalla Bowirrat, Thomas J H Chen, Kenneth Blum, Margaret Madigan, John A Bailey, Amanda Lih Chuan Chen, B William Downs, Eric R Braverman, Shahien Radi, Roger L Waite, Mallory Kerner, John Giordano, Siohban Morse, Marlene Oscar-Berman, Mark Gold
BACKGROUND AND HYPOTHESIS: Although the biological underpinnings of immediate and protracted trauma-related responses are extremely complex, 40 years of research on humans and other mammals have demonstrated that trauma (particularly trauma early in the life cycle) has long-term effects on neurochemical responses to stressful events. These effects include the magnitude of the catecholamine response and the duration and extent of the cortisol response. In addition, a number of other biological systems are involved, including mesolimbic brain structures and various neurotransmitters...
December 2010: Current Neuropharmacology