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JOURNAL ARTICLE
Tarek Okasha, Bassem Murad Mostafa, Islam Ibrahim, Ahmed Adel Abdelgawad, Cathy E Lloyd, Norman Sartorius, Hussien Elkholy
BACKGROUND: Diabetes mellitus and depression are serious common diseases, and the number of people with both conditions is rising steadily. Depression in people with diabetes mellitus results in poorer prognosis through different mechanisms. On the other hand, the presence of diabetes in individuals with depression increases functional impairment that is associated with depression. AIMS: The study aimed to assess the prevalence and factors associated with depression among adults with type 2 diabetes mellitus attending a diabetes clinic in Cairo, Egypt...
February 17, 2024: International Journal of Social Psychiatry
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JOURNAL ARTICLE
Pablo Iruzubieta, Alberto Damborenea, Mihaela Ioghen, Simon Bajew, Roberto Fernandez-Torrón, Ana Töpf, Álvaro Herrero-Reiriz, Diana Epure, Katharina Vill, Aurelio Hernández-Laín, María Manterola, Mikel Azkargorta, Oihane Pikatza-Menoio, Laura Pérez-Fernandez, Mikel García-Puga, Gisela Gaina, Alexandra Bastian, Ioana Streata, Maggie C Walter, Wolfgang Müller-Felber, Simone Thiele, Saioa Moragón, Nerea Bastida-Lertxundi, Aitziber López-Cortajarena, Felix Elortza, Gorka Gereñu, Sonia Alonso-Martin, Volker Straub, David de Sancho, Raluca Teleanu, Adolfo López de Munain, Lorea Blázquez
Alterations in RNA-splicing are a molecular hallmark of several neurological diseases, including muscular dystrophies where mutations in genes involved in RNA metabolism or characterised by alterations in RNA splicing have been described. Here, we present five patients from two unrelated families with a limb-girdle muscular dystrophy (LGMD) phenotype carrying a biallelic variant in SNUPN gene. Snurportin-1, the protein encoded by SNUPN, plays an important role in the nuclear transport of small nuclear ribonucleoproteins (snRNPs), essential components of the spliceosome...
February 15, 2024: Brain
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JOURNAL ARTICLE
Ludovica Verde, Sara Cacciapuoti, Giuseppina Caiazzo, Matteo Megna, Fabrizio Martora, Annarita Cavaliere, Maria Mattera, Maria Maisto, Gian Carlo Tenore, Annamaria Colao, Silvia Savastano, Giovanna Muscogiuri, Luigi Barrea
BACKGROUND: Hidradenitis suppurativa (HS), an inflammatory-based dermatological condition often associated with obesity, poses significant challenges in management. The very low-calorie ketogenic diet (VLCKD) has shown efficacy in addressing obesity, related metabolic disorders, and reducing chronic inflammation. However, its effects on HS remain underexplored. In this prospective pilot study, we aimed to investigate the impact of a 28-day active phase of VLCKD on HS in a sample of treatment-naive women with HS and excess weight...
February 13, 2024: Journal of Translational Medicine
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JOURNAL ARTICLE
Ganping Li, Yoshito Otake, Mazen Soufi, Masashi Taniguchi, Masahide Yagi, Noriaki Ichihashi, Keisuke Uemura, Masaki Takao, Nobuhiko Sugano, Yoshinobu Sato
PURPOSE: Manual annotations for training deep learning models in auto-segmentation are time-intensive. This study introduces a hybrid representation-enhanced sampling strategy that integrates both density and diversity criteria within an uncertainty-based Bayesian active learning (BAL) framework to reduce annotation efforts by selecting the most informative training samples. METHODS: The experiments are performed on two lower extremity datasets of MRI and CT images, focusing on the segmentation of the femur, pelvis, sacrum, quadriceps femoris, hamstrings, adductors, sartorius, and iliopsoas, utilizing a U-net-based BAL framework...
January 29, 2024: International Journal of Computer Assisted Radiology and Surgery
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JOURNAL ARTICLE
Gary Duclos, Fouzia Heireche, Manon Siroutot, Louis Delamarre, Max-Antoine Sartorius, Celine Mergueditchian, Lionel Velly, Julien Carvelli, Aurelia Bordais, Estelle Pilarczyk, Marc Leone
BACKGROUND AND IMPORTANCE: Trauma is a major cause of mortality and morbidity. Regional trauma systems are the cornerstones of healthcare systems, helping to improve outcomes and avoid preventable deaths in severe trauma patients. OBJECTIVES: The goal of this study was to evaluate the association between compliance with the guidelines of a regional trauma management system and survival at 28 days of severe trauma patients. DESIGN, SETTINGS AND PARTICIPANTS: We conducted a retrospective observational study from 1 January 2019 to 31 December 2019...
January 23, 2024: European Journal of Emergency Medicine: Official Journal of the European Society for Emergency Medicine
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JOURNAL ARTICLE
Heiko Ullrich, Alexander Sartorius, Sebastian Karl
INTRODUCTION: Theoretically, the procedural risk of electroconvulsive therapy (ECT) could be increased in the presence of undetected aneurysms due to the hemodynamic changes associated with ECT. However, empirical evidence is limited to few individual case reports and case series. METHODS: We performed a systematic review of available evidence on ECT treatment in patients with intracranial aneurysms and untreated aortic aneurysms and we retrospectively analyzed data from 252 consecutive patients referred for ECT at the Department of Psychiatry, Psychotherapy and Psychosomatics of Siegen Hospital, Germany, who received magnetic resonance angiographies and abdominal sonographies as part of their routine pre-ECT workup...
January 25, 2024: Journal of ECT
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JOURNAL ARTICLE
Kenji Kawamura, Hiroshi Okada, Naoki Maegawa, Hideo Hasegawa, Shohei Omokawa, Pasuk Mahakkanukrauh, Yasuhito Tanaka
PURPOSE: The medial approach to the popliteal artery has been less commonly used than the posterior approach in surgical repair of traumatic popliteal injury. This study was performed to quantitatively evaluate the visual field of the popliteal artery obtained by staged myotendotomy in the medial approach to the popliteal artery. METHODS: Twenty legs of fresh-frozen adult cadavers were dissected using the medial approach to the popliteal artery. In stage 1, the popliteal artery was exposed between the vastus medialis and sartorius muscles without myotendotomy...
January 23, 2024: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
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JOURNAL ARTICLE
Kurt Sartorius, Benn Sartorius, Cheryl Winkler, Anil Chuturgoon, Tsai-Wei Shen, Yongmei Zhao, Ping An
The incidence and mortality of hepatocellular carcinoma (HCC) in Sub-Saharan Africa is projected to increase sharply by 2040 against a backdrop of limited diagnostic and therapeutic options. Two large South African-based case control studies have developed a serum-based miRNome for Hepatitis B-associated hepatocellular carcinoma (HBV-HCC), as well as identifying their gene targets and pathways. Using a combination of RNA sequencing, differential analysis and filters including a unique molecular index count (UMI) ≥ 10 and log fold change (LFC) range > 2: <-0...
January 12, 2024: International Journal of Molecular Sciences
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JOURNAL ARTICLE
Charlotte Gabriel, Alban Fouasson Chailloux, Thomas Jager, Germain Pomares
INTRODUCTION: We conducted an anatomic feasibility study of a sartorius myocutaneous flap with a distally based pedicle and proximal skin paddle to cover soft tissue defects of the knee region. HYPOTHESIS: A recent anatomic study by Mojalla showed that the sartorius muscle had 2 distinct pedicles, making it possible to isolate this muscle on its distal pedicle and harvest it with a skin paddle. MATERIALS AND METHODS: This anatomic study was conducted on 10 lower limbs...
January 19, 2024: Orthopaedics & Traumatology, Surgery & Research: OTSR
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JOURNAL ARTICLE
Jibao Wu, Jiping Yi, Wenhua Zhu, Dongyue Yue, Bin Chen
OBJECTIVE: To explore the clinical characteristics and genetic variant of a patient with desminopathy manifesting with atypical symptoms. METHODS: A patient who was admitted to the Department of Neurology of Jing'an District Central Hospital on February 24, 2021 was selected as the study subject. Clinical data, laboratory tests, muscle pathology, muscle magnetic resonance imaging (MRI) and genetic testing of the patient were retrospectively analyzed. RESULTS: The patient had developed myalgia after lower limb activity, and gradually developed asymmetrical muscle weakness and atrophy of the lower limbs...
January 10, 2024: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
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JOURNAL ARTICLE
Konstantinos Natsis, Christos Koutserimpas, Trifon Totlis, George Triantafyllou, George Tsakotos, Katerina Al Nasraoui, Filippos Karageorgos, Maria Piagkou
The current cadaveric report describes an unusual morphology of the sartorius muscle (SM), the biceps-bicaudatus variant. The SM had two (lateral and medial) heads, with distinct tendinous origins from the anterior superior iliac spine. The lateral head was further split into a lateral and a medial bundle. The anterior cutaneous branch of the femoral nerve emerged between the origins of the lateral and medial heads. SM morphological variants are exceedingly uncommon, with only a few documented cases in the literature, and several terms used for their description...
January 3, 2024: Anatomy & Cell Biology
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JOURNAL ARTICLE
D J Handelsman, G Sartorius, R Desai, A Idan, L Turner, S Savkovic, L P Ly, E Forbes, C A Allan, R McLachlan, A J Conway
OBJECTIVE: Serum testosterone measurements in clinical practice mostly utilize "direct" (non-extraction) immunoassays which have method-specific bias due to steroid cross-reactivity and non-specific matrix artefacts. Although more accurate, sensitive, and specific liquid chromatography-mass spectrometry (LCMS) dominates in clinical research, the within-person variability of serum testosterone in healthy men using LCMS measurement is not reported. DESIGN: Longitudinal multi-sampling observational study of men in excellent health over three months...
December 23, 2023: European Journal of Endocrinology
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JOURNAL ARTICLE
Amel Raboudi, Pierre-Yves Hervé, Marianne Allanic, Philippe Boutinaud, Jean-Joseph Christophe, Hüseyin Firat, Elie Mousseaux, Mathieu Pernot, Pierre Prot, Alfonso Sartorius-Carvajal, Frédérique Chézalviel-Guilbert, Jean-Sébastien Hulot
With the emergence of health data warehouses and major initiatives to collect and analyze multi-modal and multisource data, data organization becomes central. In the PACIFIC-PRESERVED (PhenomApping, ClassIFication, and Innovation for Cardiac Dysfunction - Heart Failure with PRESERVED LVEF Study, NCT04189029) study, a data driven research project aiming at redefining and profiling the Heart Failure with preserved Ejection Fraction (HFpEF), an ontology was developed by different data experts in cardiology to enable better data management in a complex study context (multisource, multiformat, multimodality, multipartners)...
December 20, 2023: Journal of Biomedical Informatics
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REVIEW
Mrugesh Vaishnav, Afzal Javed, Snehil Gupta, Vinay Kumar, Parth Vaishnav, Akash Kumar, Hakimullah Salih, Petros Levounis, Bernardo Ng, Samia Alkhoori, Cora Luguercho, Armen Soghoyan, Elizabeth Moore, Vinay Lakra, Martin Aigner, Johannes Wancata, Jamila Ismayilova, Md Azizul Islam, Antonio Geraldo Da Silva, Gary Chaimowitz, Wang Xiaoping, Tarek Okasha, Andreas Meyer-Lindenberg, Thomas Schulze, Roger Ng, S N Chiu, Chan Kit Wa Sherry, Andi J Tanra, Yong Chon Park, Liliya Panteleeva, Marisol Taveras, Ramune Mazaliauskiene, Ahmad Hatim Bin Sulaiman, Thelma Sanchez, Chandra Prasad Sedain, Taiwo Lateef Sheikh, Lars Lien, Ghulam Rasool, Robert Buenaventura, Harish Chandra Gambheera, Kapila Ranasinghe, Norman Sartorius, Chawanun Charnsil, Amine Larnaout, Juliet Nakku, Zarif Ashurov
BACKGROUND: Stigma related to mental illness (and its treatment) is prevalent worldwide. This stigma could be at the structural or organizational level, societal level (interpersonal stigma), and the individual level (internalized stigma). Vulnerable populations, for example, gender minorities, children, adolescents, and geriatric populations, are more prone to stigma. The magnitude of stigma and its negative influence is determined by socio-cultural factors and macro (mental health policies, programs) or micro-level factors (societal views, health sectors, or individuals' attitudes towards mentally ill persons)...
October 2023: Indian Journal of Psychiatry
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JOURNAL ARTICLE
Moritz Spangemacher, Xenia Marlene Hart, Elea Saalfrank, Gerhard Gründer, Jonathan Reinwald, Alexander Sartorius
No abstract text is available yet for this article.
January 2024: Journal of Clinical Psychopharmacology
#36
JOURNAL ARTICLE
Fei Peng, Deqiu Tang, Weipeng Qing, Wei Chen, Shuhao Li, Yingkun Guo, Guanghua Luo, Heng Zhao
BACKGROUND: It is challenging to diagnose suspected Duchenne muscular dystrophy (DMD) patients in the very early stage of the disease. More evidence is needed to demonstrate the potential of quantitative MRI (qMRI) in precisely identifying patients before substantial physical decline occurs. PURPOSE: To assess the early diagnostic performance of multi-parametric qMRI for DMD patients, and the ability to identify DMD patients with mild functional decline. STUDY TYPE: Prospective...
December 14, 2023: Journal of Magnetic Resonance Imaging: JMRI
#37
Miklos Argyelan, Zhi-De Deng, Olga Therese Ousdal, Leif Oltedal, Brian Angulo, Mate Baradits, Andrew J Spitzberg, Ute Kessler, Alexander Sartorius, Annemiek Dols, Katherine L Narr, Randall Espinoza, Jeroen A van Waarde, Indira Tendolkar, Philip van Eijndhoven, Guido A van Wingen, Akihiro Takamiya, Taishiro Kishimoto, Martin B Jorgensen, Anders Jorgensen, Olaf B Paulson, Antoine Yrondi, Patrice Péran, Carles Soriano-Mas, Narcis Cardoner, Marta Cano, Linda van Diermen, Didier Schrijvers, Jean-Baptiste Belge, Louise Emsell, Filip Bouckaert, Mathieu Vandenbulcke, Maximilian Kiebs, René Hurlemann, Peter Cr Mulders, Ronny Redlich, Udo Dannlowski, Erhan Kavakbasi, Michael D Kritzer, Kristen K Ellard, Joan A Camprodon, Georgios Petrides, Anil K Malhotra, Christopher C Abbott
No abstract text is available yet for this article.
December 5, 2023: Molecular Psychiatry
#38
Liam S Carroll, Sarah Ennis, Nicola Foulds, Simon R Hammans
Genetic variation at HNRNPA2B1 is associated with inclusion body myopathy, Paget's disease and paediatric onset oculopharyngeal muscular dystrophy. We present a pedigree where a mother and two daughters presented with adolescent to early-adulthood onset of symptoms reminiscent of oculopharyngeal muscular dystrophy or chronic progressive external ophthalmoplegia, with a later limb-girdle pattern of weakness. Creatine Kinase was ∼1000 U/L. Myoimaging identified fatty replacement of sartorius, adductors longus and magnus, biceps femoris, semitendinosus and gastrocnemii...
November 17, 2023: Neuromuscular Disorders: NMD
#39
JOURNAL ARTICLE
Fumihiro Yoshimura, Taiki Matsunaga, Koichi Kinoshita, Hajime Seo, Kenichiro Doi, Takuaki Yamamoto
BACKGROUND: Curved periacetabular osteotomy requires detachment and retraction of the hip flexors. In this study, we evaluated hip flexor muscle status by magnetic resonance imaging (MRI) shortly after curved periacetabular osteotomy. METHODS: We retrospectively evaluated 60 hips of 56 patients by MRI 1 week and 3 months after curved periacetabular osteotomy performed from August 2017 to December 2019. We classified the condition of the flexors as follows: Grade 0, normal; Grade I, strain/edema; Grade II, partial tear; and Grade III, complete tear...
November 29, 2023: Journal of Arthroplasty
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JOURNAL ARTICLE
Hugo Legge, Rachel L Pullan, Benn Sartorius
Enteric and parasitic infections such as soil-transmitted helminths cause considerable mortality and morbidity in low- and middle-income settings. Earthen household floors are common in many of these settings and could serve as a reservoir for enteric and parasitic pathogens, which can easily be transmitted to new hosts through direct or indirect contact. We conducted a systematic review and meta-analysis to establish whether and to what extent improved household floors decrease the odds of enteric and parasitic infections among occupants compared with occupants living in households with unimproved floors...
2023: PLOS Glob Public Health
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