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https://www.readbyqxmd.com/read/27906065/dystrophin-deficient-dogs-with-reduced-myostatin-have-unequal-muscle-growth-and-greater-joint-contractures
#1
Joe N Kornegay, Daniel J Bogan, Janet R Bogan, Jennifer L Dow, Jiahui Wang, Zheng Fan, Naili Liu, Leigh C Warsing, Robert W Grange, Mihye Ahn, Cynthia J Balog-Alvarez, Steven W Cotten, Monte S Willis, Candice Brinkmeyer-Langford, Hongtu Zhu, Joe Palandra, Carl A Morris, Martin A Styner, Kathryn R Wagner
BACKGROUND: Myostatin (Mstn) is a negative regulator of muscle growth whose inhibition promotes muscle growth and regeneration. Dystrophin-deficient mdx mice in which myostatin is knocked out or inhibited postnatally have a less severe phenotype with greater total mass and strength and less fibrosis and fatty replacement of muscles than mdx mice with wild-type myostatin expression. Dogs with golden retriever muscular dystrophy (GRMD) have previously been noted to have increased muscle mass and reduced fibrosis after systemic postnatal myostatin inhibition...
April 4, 2016: Skeletal Muscle
https://www.readbyqxmd.com/read/27890838/preoperative-evaluation-of-the-renal-function-before-the-treatment-of-abdominal-aortic-aneurysms
#2
Raphael Coscas, Sandra Wagner, Eve Vilaine, Albane Sartorius, Isabelle Javerliat, Olivier Goeau-Brissonniere, Marc Coggia, Ziad Massy
OBJECTIVES: Chronic impaired renal function (IRC) constitutes a major risk factor of morbi-mortality during the treatment of an abdominal aortic aneurism (AAA). The inflammatory state due to the AAA could result in a reduction in the muscular mass and an over-estimation of the glomerular filtration rate (GFR) with the usual formulas. The objective of this study was to determine if the formulae used to evaluate the estimated GFR were adapted in patients with AAA. MATERIALS AND METHODS: Between August 2013 and November 2014, we conducted an exploratory study to evaluate the renal function before surgery for AAA in 28 patients...
November 24, 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27876183/electroconvulsive-therapy-selectively-enhances-amyloid-%C3%AE-1-42-in-the-cerebrospinal-fluid-of-patients-with-major-depression-a-prospective-pilot-study
#3
Laura Kranaster, Suna Su Aksay, Jan Malte Bumb, Christoph Janke, Angelika Alonso, Carolin Hoyer, Inga Zerr, Matthias Schmitz, Lucrezia Hausner, Lutz Frölich, Alexander Sartorius
A complex interplay between β-amyloid (Aβ), Alzheimer׳s disease (AD) and major depression disorder (MDD) suggests that patients with MDD have an altered cerebral Aβ metabolism and an increased risk of developing AD. In order to elucidate the relationship between antidepressant treatment and Aβ metabolism in humans, we performed a study on Aβ peptides in the cerebrospinal fluid (CSF) in patients with MDD during electroconvulsive therapy (ECT) as an effective antidepressant treatment. We measured the levels of Aβ1-42, Aβ1-40 and of tau proteins in the CSF in 12 patients with MDD before and after a course of ECT...
November 18, 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27871133/civilian-cerebral-gunshot-wounds-a-south-african-experience
#4
Victor Kong, Jocinta Odendaal, Benn Sartorius, Damian Clarke, Petra Brysiewicz, Ellen Jerome, John Bruce, Grant Laing
BACKGROUND: Cerebral gunshot wounds represent one of the most lethal forms of traumatic brain injury, but there is a paucity of literature on the topic, especially from the developing world. We reviewed our experience and describe the spectrum and outcome of civilian cerebral gunshot wounds in a major metropolitan trauma centre in South Africa. METHODS: This was a retrospective study of all patients with isolated cerebral gunshot wounds managed by the Pietermaritzburg Metropolitan Trauma Service over a 5-year period from 2010 to 2014...
November 21, 2016: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/27866232/surgical-treatment-of-two-adolescent-athletes-with-dislocated-avulsion-fracture-of-the-anterior-superior-iliac-spine-asis
#5
Lukas Willinger, Jakob E Schanda, Stephan Lorenz, Andreas B Imhoff, Stefan Buchmann
INTRODUCTION: Avulsion fractures of the anterior superior iliac spine are rare. Therefore, evidence-based treatment guidelines do not exist. The therapeutic options are either conservative treatment or surgical intervention. The decision depends on grade of dislocation, age of the patient, and his sportive demands and competitive requirements. MATERIALS AND METHODS: We present the cases of two young athletes suffering from traumatic avulsion fractures of the anterior superior iliac spine...
November 19, 2016: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/27859916/mild-thyrotoxicosis-leads-to-brain-perfusion-changes-an-arterial-spin-labeling-study
#6
Anna Göbel, Marcus Heldmann, Alexander Sartorius, Martin Göttlich, Anna-Luise Dirk, Georg Brabant, Thomas F Münte
Hypo- and hyperthyroidism have effects on brain structure and function as well as cognitive processes, including memory. However, little is known about the influence of thyroid hormones on brain perfusion and the relationship of such perfusion changes to cognition. This study aimed to demonstrate the effect of short-term experimental hyperthyroidism on brain perfusion in healthy volunteers and to assess whether perfusion changes, if present, are related to cognitive performance. It is known that an interaction exists between brain perfusion and cerebral oxygen consumption rate and it is believed that neural activation increases cerebral regional perfusion rate in brain areas associated with memory...
November 9, 2016: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/27855419/global-mental-health-a-re-emerging-movement-the-vision-and-the-implementation
#7
Norman Sartorius
No abstract text is available yet for this article.
December 2016: Psychiatria Danubina
https://www.readbyqxmd.com/read/27846646/the-variable-emergence-of-the-infrapatellar-branch-of-the-saphenous-nerve
#8
Brandon Michael Henry, Krzysztof A Tomaszewski, Przemysław A Pękala, Piravin Kumar Ramakrishnan, Dominik Taterra, Karolina Saganiak, Ewa Mizia, Jerzy A Walocha
The infrapatellar branch of the saphenous nerve (IPBSN) is a cutaneous nerve of the lower limb, which arises distal to the adductor canal. High variability in the emergence, course, branching, termination, and morphometrics of the IPBSN poses an increased risk of injury to the nerve during surgical interventions on the anteromedial aspect of the knee. The aim of this study was to describe the anatomical characteristics of the IPBSN. This study utilized cadaveric (n = 100) and ultrasonography (n = 30) assessments, and meta-analysis...
November 15, 2016: Journal of Knee Surgery
https://www.readbyqxmd.com/read/27843924/south-italy-a-privileged-perspective-to-understand-the-relationship-between-hidradenitis-suppurativa-and-overweight-obesity
#9
Gabriella Fabbrocini, Valerio De Vita, Marianna Donnarumma, Giuseppe Russo, Giuseppe Monfrecola
BACKGROUND: Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition that involves the terminal hair follicles of apocrine gland-bearing skin areas. OBJECTIVE: To evaluate the relationship between HS and systemic medical conditions, such as overweight/obesity during adolescence. METHODS: Epidemiologic data was collected from January 2014 up to December 2015 from 27 patients affected by HS, outpatients of the Dermatology Department of University of Naples Federico II, to examine the correlation between HS and overweight/obesity...
September 2016: Skin Appendage Disorders
https://www.readbyqxmd.com/read/27843200/mmp8-is-increased-in-lesions-and-blood-of-acne-inversa-patients-a-potential-link-to-skin-destruction-and-metabolic-alterations
#10
Athanasia Tsaousi, Ellen Witte, Katrin Witte, Hans-Joachim Röwert-Huber, Hans-Dieter Volk, Wolfram Sterry, Kerstin Wolk, Sylke Schneider-Burrus, Robert Sabat
Acne inversa (AI; also designated as hidradenitis suppurativa) is a chronic inflammatory disease with still unknown pathogenesis that affects the intertriginous skin of perianal, inguinal, and axillary sites. It leads to painful nodules, abscesses, and fistulas with malodorous secretion and is frequently associated with metabolic alterations. Here, we demonstrate that one of the most highly upregulated molecules in AI lesions is matrix metalloproteinase 8 (MMP8), an enzyme specialized in the degradation of extracellular matrix components and the HDL component apolipoprotein A-I...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27842639/elevated-international-normalised-ratios-correlate-with-severity-of-injury-and-outcome
#11
M A Noorbhai, H M Cassimjee, B Sartorius, D J J Muckart
BACKGROUND: Haemorrhagic shock is the leading cause of preventable early deaths from trauma. Acute coagulopathy on admission to a trauma unit is associated with worse outcomes. The relationship of haemorrhage to early mortality remains consistent regardless of mechanism of injury. Haemorrhage and haemorrhagic shock are increasingly amenable to interventions that result in reductions in morbidity and mortality. OBJECTIVES: To assess the prevalence of coagulopathy in patients admitted to the level 1 trauma unit at Inkosi Albert Luthuli Central Hospital, Durban, South Africa, and correlate it with in-hospital mortality...
November 2, 2016: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/27830881/transtendinous-course-of-the-infrapatellar-branch-of-saphenous-nerve-a-contribution-to-the-etiology-of-entrapment-neuropathy-and-modification-of-the-existing-classification
#12
Konstantinos Natsis, Georgios Konstantinidis, Georgios Geropoulos, Trifon Totlis, Nikolaos Lazaridis, Thomas Tegos
BACKGROUND: The course of the infrapatellar branch of saphenous nerve (IPBSN) in relation to the Sartorius muscle has been classified into presartorial, transsartorial and retrosartorial types. Mechanical compression of the IPBSN within the sartorius tendon has been surgically recognized as a cause of entrapment neuropathy. Purpose of the present study was to differentiate the IPBSNs penetrating the sartorius tendon from those penetrating the sartorius muscle, from an anatomical and clinical point of views and thus modifying the existing classification...
November 10, 2016: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/27830876/positional-changes-in-tendon-insertions-from-bone-to-fascia-development-of-the-pes-anserinus-and-semimembranosus-muscle-insertion-in-human-fetuses
#13
Zhe Wu Jin, Hiroshi Abe, Yu Jin, Shunichi Shibata, Gen Murakami, José Francisco Rodríguez-Vázquez
Development of a long muscle belly in fetal extremities generally requires a definite bony insertion of the long tendon. However, in adults, the pes anserinus and the semimembranosus tendon are inserted into fasciae. Development of fascial insertions in fetuses was investigated by examining serial histological sections obtained from seven fetuses at 8-9 weeks and eight fetuses at 14-16 weeks. The presence of matrix substances and macrophages was also examined by immunohistochemistry. At 8 weeks, the tendons of the semitendinosus, gracilis, sartorius and semimembranosus muscles were straight and inserted into the initial shaft-like proximal end of the tibia on the proximal side of the popliteus muscle...
November 10, 2016: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/27828926/alcohol-use-disorder-as-a-possible-predictor-of-electroconvulsive-therapy-response
#14
Suna Su Aksay, Melanie Hambsch, Christoph Janke, Jan Malte Bumb, Laura Kranaster, Alexander Sartorius
INTRODUCTION: Two rapidly acting antidepressive treatment forms, namely, electroconvulsive therapy (ECT) and ketamine, possibly share a common mechanism of action primarily involving alterations of neurotransmission (glutamate and γ-aminobutyric acid levels). Because patients receiving ketamine and with a coexistent family history of an alcohol use disorder (AUD) seem to benefit from consistent and longer lasting antidepressive effects, we hypothesized better treatment response in ECT patients with an own history or a family history of an AUD...
November 8, 2016: Journal of ECT
https://www.readbyqxmd.com/read/27811930/defining-the-brain-circuits-involved-in-psychiatric-disorders-imi-newmeds
#15
Francesc Artigas, Esther Schenker, Pau Celada, Michael Spedding, Laia Lladó-Pelfort, Noemi Jurado, Mercedes Núñez, Noemi Santana, Eva Troyano-Rodriguez, Maurizio S Riga, Hanna van den Munkhof, Anna Castañé, Hamdy Shaban, Thérèse M Jay, Anushree Tripathi, Bill P Godsil, Claude Sebban, Jean Mariani, Philippe Faure, Samir Takkilah, Zoe A Hughes, Chester J Siok, Mihaily Hajos, Karsten Wicke, Natalia Gass, Wolfgang Weber-Fahr, Alexander Sartorius, Robert Becker, Michael Didriksen, Jesper F Bastlund, Mark Tricklebank, Céline Risterucci, Andreas Meyer-Lindenberg, Adam J Schwarz
Despite the vast amount of research on schizophrenia and depression in the past two decades, there have been few innovative drugs to treat these disorders. Precompetitive research collaborations between companies and academic groups can help tackle this innovation deficit, as illustrated by the achievements of the IMI-NEWMEDS consortium.
November 4, 2016: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/27807706/is-clinical-research-in-oesophageal-cancer-in-south-africa-in-crisis-a-systematic-review
#16
REVIEW
E Loots, B Sartorius, T E Madiba, C J J Mulder, D L Clarke
Oesophageal cancer (OC) is responsible for the second highest number of cancer-related deaths in South Africa (SA). Squamous cell carcinoma is the most prevalent type with an incidence of 46.7/100,000 and 19.2/100,000 for males and females. This is a systematic review of the clinical diagnosis and management of OC within the South African context. This protocol was registered with the International Prospective Register of Systematic Reviews (PROSPERO) (registration number CRD42016034053) with adherence to PRISMA guidelines...
November 2, 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/27796944/steroid-hormone-receptor-positive-breast-cancer-patient-derived-xenografts
#17
Shawna B Matthews, Carol A Sartorius
The vast majority of breast cancers are positive for estrogen receptor (ER) and depend on estrogens for growth. These tumors are treated with a variety of ER-targeted endocrine therapies, although eventual resistance remains a major clinical problem. Other steroid hormone receptors such as progesterone receptor (PR) and androgen receptor (AR) are emerging as additional prospective targets in breast cancer. The fundamental mechanism of action of these steroid receptors in gene regulation has been defined mainly by several breast cancer cell lines that were established in the late 1970s...
October 28, 2016: Hormones & Cancer
https://www.readbyqxmd.com/read/27777087/small-femoral-offset-is-a-risk-factor-for-lateral-femoral-cutaneous-nerve-injury-during-total-hip-arthroplasty-using-a-direct-anterior-approach
#18
Y Ozaki, Y Homma, K Sano, T Baba, H Ochi, A Desroches, M Matsumoto, T Yuasa, K Kaneko
INTRODUCTION: Lateral femoral cutaneous nerve (LFCN) injury is a risk specific to the direct anterior approach (DAA) for total hip arthroplasty (THA). However, prevention strategies have not been established. This study aimed to identify the predisposing factors determining LFCN injury during THA via a DAA. HYPOTHESIS: Patients with LFCN injury after THA via DAA would demonstrate predisposing factors. MATERIAL AND METHODS: LFCN injury was identified using a patient questionnaire...
December 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/27753726/factors-associated-with-antidepressant-dosing-in-asia-findings-from-the-research-on-asian-psychotropic-prescription-study
#19
Kamini Rajaratnam, Yu-Tao Xiang, Adarsh Tripathi, Helen Fung Kum Chiu, Tian-Mei Si, Kok-Yoon Chee, Ajit Avasthi, Sandeep Grover, Mian-Yoon Chong, Hironori Kuga, Shigenobu Kanba, Yan-Ling He, Min-Soo Lee, Shu-Yu Yang, Pichet Udomratn, Roy Abraham Kallivayalil, Andi J Tanra, Margarita Maramis, Winston Wu-Dien Shen, Norman Sartorius, Ee-Heok Kua, Chay-Hoon Tan, Rathi Mahendran, Naotaka Shinfuku, Min Yi Sum, Ross J Baldessarini, Kang Sim
In this study, we sought to examine factors associated with dosing of antidepressants (ADs) in Asia. Based on reported data and clinical experience, we hypothesized that doses of ADs would be associated with demographic and clinical factors and would increase over time. This cross-sectional, pharmacoepidemiological study analyzed data collected within the Research Study on Asian Psychotropic Prescription Pattern for Antidepressants from 4164 participants in 10 Asian countries, using univariate and multivariate methods...
October 5, 2016: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27752168/-magnetic-resonance-imaging-of-dystrophinopathy-that-mimics-adductor-enthesopathy
#20
Y M Zheng, W Z Li, Z X Wang, W Zhang, H Lv, J X Xiao, Y Yuan
OBJECTIVE: To report thigh muscle magnetic resonance imaging (MRI) tests of four Chinese patients with dystrophinopathy with edema changes in adductor longus muscles that mimics adductor enthesopathy. METHODS: Four boys, who were from four unrelated families and aged from 5 to 11 years, were investigated because of the clinical manifestations including myalgia or muscle weakness or the incidental findings of elevated serum creatine kinase levels, and were diagnosed with dystrophinopathy by gene test of Duchenne muscular dystrophy (DMD)...
October 18, 2016: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
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