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https://www.readbyqxmd.com/read/29325465/prevalence-of-positive-quantiferon-gold-in-tube-testing-in-hidradenitis-suppurativa
#1
Tina Boortalary, Kanchan Misra, Sean McNish, Derek Jones, Victoria K Shanmugam
AIM: Hidradenitis suppurativa (HS) is a chronic, recurrent, inflammatory disease of the apocrine sweat glands. Tumor necrosis factor-alpha (TNF-α) inhibitors are commonly used to treat HS. However, prior to initiating therapy patients must be screened for mycobacterium tuberculosis (mTB) exposure. Several mTB screening tests based on interferon gamma release assays are commercially available, but the performance of these assays in the HS population is unknown. The purpose of this study was to investigate the performance of the QuantiFERON gold in-tube assay (QFT-GIT) in a cohort of patients with HS...
January 22, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29316916/malaria-programme-personnel-s-experiences-perceived-barriers-and-facilitators-to-implementing-malaria-elimination-strategy-in-south-africa
#2
Khumbulani Welcome Hlongwana, Benn Sartorius, Joyce Tsoka-Gwegweni
BACKGROUND: South Africa has set an ambitious goal targeting to eliminate malaria by 2018, which is consistent with the United Nations Sustainable Development Goals' call to end the epidemic of malaria by 2030 across the globe. There are conflicting views regarding the feasibility of malaria elimination, and furthermore studies investigating malaria programme personnel's perspectives on strategy implementation are lacking. METHODS: The study was a cross-sectional survey conducted in 2014 through a face-to-face investigator-administered semi-structured questionnaire to all eligible and consenting malaria programme personnel (team leader to senior manager levels) in three malaria endemic provinces (KwaZulu-Natal, Mpumalanga, and Limpopo) of South Africa...
January 10, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29315294/the-oral-vegf-receptor-tyrosine-kinase-inhibitor-pazopanib-in-combination-with-the-mek-inhibitor-trametinib-in-advanced-cholangiocarcinoma
#3
Rachna T Shroff, Mark Yarchoan, Ashley O'Connor, Denise Gallagher, Marianna L Zahurak, Gary Rosner, Chimela Ohaji, Susan Sartorius-Mergenthaler, Rose Parkinson, Vivek Subbiah, Ralph Zinner, Nilofer S Azad
This corrects the article DOI: 10.1038/bjc.2017.119.
January 9, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29305627/antagonism-at-the-nr2b-subunit-of-nmda-receptors-induces-increased-connectivity-of-the-prefrontal-and-subcortical-regions-regulating-reward-behavior
#4
Natalia Gass, Robert Becker, Markus Sack, Adam J Schwarz, Jonathan Reinwald, Alejandro Cosa-Linan, Lei Zheng, Christian Clemm von Hohenberg, Dragos Inta, Andreas Meyer-Lindenberg, Wolfgang Weber-Fahr, Peter Gass, Alexander Sartorius
RATIONALE: Evidence indicates that ketamine's rapid antidepressant efficacy likely results from its antagonism of NR2B-subunit-containing NMDA receptors (NMDAR). Since ketamine equally blocks NR2A- and NR2B-containing NMDAR, and has affinity to other receptors, NR2B-selective drugs might have improved therapeutic efficiency and side effect profile. OBJECTIVES: We aimed to compare the effects of (S)-ketamine and two different types of NR2B-selective antagonists on functional brain networks in rats, in order to find common circuits, where their effects intersect, and that might explain their antidepressant action...
January 5, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29300904/identifying-corridors-of-hiv-transmission-in-a-severely-affected-rural-south-african-population-a-case-for-a-shift-toward-targeted-prevention-strategies
#5
Frank Tanser, Till Bärnighausen, Adrian Dobra, Benn Sartorius
Background: In the context of a severe generalized African HIV epidemic, the value of geographically targeted prevention interventions has only recently been given serious consideration. However, to date no study has performed a population-based analysis of the micro-geographical clustering of HIV incident infections, limiting the evidential support for such a strategy. Methods: We followed 17 984 HIV-uninfected individuals aged 15-54 in a population-based cohort in rural KwaZulu-Natal, South Africa, and observed individual HIV sero-conversions between 2004 and 2014...
December 28, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29287785/evaluation-of-muscle-activity-just-after-straight-leg-raising-exercise-by-using-18fdg-pet
#6
Hiroyuki Shiozawa, Takashi Ohsawa, Yoshito Tsushima, Tetsuya Higuchi, Kenji Takagishi, Hirotaka Chikuda
BACKGROUND: Exercise therapy is one of the recognized treatment methods for knee osteoarthritis (KOA). One such exercise technique, straight leg raising (SLR), is widely known as a home exercise method for strengthening the quadriceps femoris muscle. However, whether this exercise truly strengthens the quadriceps is not known. The objective of the present study was to investigate which lower limb muscle is stimulated and shows increased activity with SLR. METHODS: A total of 14 lower limbs in seven healthy adult male volunteers (mean age: 31...
December 26, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/29282036/circulating-microrna-s-as-a-diagnostic-tool-for-hepatocellular-carcinoma-in-a-hyper-endemic-hiv-setting-kwazulu-natal-south-africa-a-case-control-study-protocol-focusing-on-viral-etiology
#7
K Sartorius, B Sartorius, A Kramvis, E Singh, A Turchinovich, B Burwinkel, T Madiba, C A Winkler
BACKGROUND: A wide range of studies has investigated the diagnostic proficiency of extracellular microRNAs (miRNAs) in hepatocellular cancer (HCC). HCC is expected to increase in Sub-Saharan Africa (SSA), due to endemic levels of viral infection (HBV/HIV), ageing and changing lifestyles. This unique aetiological background provides an opportunity for investigating potentially novel circulating miRNAs as biomarkers for HCC in a prospective study in South Africa. METHODS: This study will recruit HCC patients from two South African cancer hospitals, situated in Durban and Pietermaritzburg in the province of KwaZulu-Natal...
December 28, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29274997/electroconvulsive-therapy-enhances-the-anti-ageing-hormone-klotho-in-the-cerebrospinal-fluid-of-geriatric-patients-with-major-depression
#8
Carolin Hoyer, Alexander Sartorius, Suna Su Aksay, Jan Malte Bumb, Christoph Janke, Manfred Thiel, Dieter Haffner, Maren Leifheit-Nestler, Laura Kranaster
Klotho is a humoral factor with pleiotropic effects. Most notably, Klotho deficiency is associated with a phenotype comprising organ manifestations accompanying aging including atherosclerosis and cognitive impairment. Research on the role of Klotho in affective disorder is scarce, which is surprising in light of the fact that depression is associated with accelerated cellular aging as well as aging-related phenotypes and comorbidity observed in Klotho deficiency. On these grounds we investigated Klotho levels in the cerebrospinal fluid (CSF) and serum of eight geriatric patients undergoing electroconvulsive therapy (ECT) for severe depression...
December 20, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29244658/a-distally-based-sartorius-muscle-flap-for-a-gustilo-grade-iii-open-fracture-of-the-lateral-femoral-condyle-and-the-head-of-the-fibula-with-a-complex-soft-tissue-defect-a-case-report-and-review-of-the-literature
#9
Victoire Bouveau, Damien Potage, Arnaud Dubory, Romain Chevallier, Jean-Paul Meningaud, Jérémy Niddam, Charles-Henri Flouzat-Lachaniette
CASE: We present a case of lower-limb trauma associated with an extensive soft-tissue defect around the knee joint, which led to the exposure of bone and the metalwork that was used for the management of the associated fractures. Coverage was performed with a distally based sartorius muscle flap in a single-stage procedure, allowing good recovery with a nice aesthetic and functional outcome at the 1-year follow-up. Additionally, we discuss alternative options for the coverage of severe soft-tissue defects based on the clinical context...
December 13, 2017: JBJS Case Connector
https://www.readbyqxmd.com/read/29242711/effect-of-point-of-care-diagnostics-on-maternal-outcomes-in-human-immunodeficiency-virus-infected-women-systematic-review-and-meta-analysis
#10
Tivani P Mashamba-Thompson, Rebecca L Morgan, Benn Sartorius, Brittany Dennis, Paul K Drain, Lehana Thabane
Introduction: The World Health Organization advocates for increased accessibility of HIV-related point-of-care (POC) diagnostics in settings that lack laboratory infrastructure. The aim of this study is to assess the impact of POC diagnostics on maternal health outcomes in HIV-infected women. Methods: A systematic literature review used multiple data sources as follows: Cochrane Infectious Disease Group Specialized Register; Cochrane Central Register of Control Trials, published in The Cochrane Library; PubMed; EBSCOhost and LILACS from January 2000 to October 2015...
June 2017: Point of Care
https://www.readbyqxmd.com/read/29231053/the-contribution-of-malodour-in-quality-of-life-of-patients-with-hidradenitis-suppurativa
#11
Afsaneh Alavi, Delaram Farzanfar, Rosa Kyuwon Lee, Dalal Almutairi
BACKGROUND: Malodourous discharge in patients with hidradenitis suppurativa (HS) has a strong psychosocial impact and is often reported as a source of embarrassment, low self-esteem, social stigma, and barriers to interpersonal relationships. Malodour is a maker of bacterial colonization, and its role in HS is understudied. OBJECTIVES: The aim of this study is to assess the relationship between severity of malodourous discharge and quality-of-life impairment in patients with HS...
December 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29227053/quantifying-the-funding-gap-for-management-of-traumatic-brain-injury-at-a-major-trauma-centre-in-south-africa
#12
V Y Kong, J J Odendaal, J L Bruce, G L Laing, E Jerome, B Sartorius, P Brysiewicz, D L Clarke
BACKGROUND: Trauma is an eminently preventable disease. However, prevention programs divert resources away from other priorities. Costing trauma related diseases helps policy makers to make decisions on re-source allocation. We used data from a prospective digital trauma registry to cost Traumatic Brain Injury (TBI) at our institution over a two-year period and to estimate the funding gap that exists in the care of TBI. METHOD: All patients who were admitted to the Pietermaritzburg Metropolitan Trauma Service (PMTS) with TBI were identified from the Hybrid Electronic Medical Registry (HMER)...
November 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/29227050/barriers-to-accessing-atls-provider-course-for-junior-doctors-at-a-major-university-hospital-in-south-africa
#13
J J Odendaal, V Y Kong, T Liu, B Sartorius, G V Oosthuizen, D L Clarke
BACKGROUND: Advanced trauma life support (ATLS) is the international standard of care and forms the basis of trauma training in South Africa. Previous local studies demonstrated a low completion rate among junior doctors (JD). This study was designed to determine the reasons and identify possible barriers of JDs to accessing the ATLS course at a major university hospital. METHOD: This was a prospective study utilising a structured survey that included all JDs who were undertaking their internship training...
November 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/29224229/power-doppler-ultrasound-assessment-of-vascularization-in-hidradenitis-suppurativa-lesions
#14
Raffaele Dante Caposiena Caro, Francesco Maria Solivetti, Luca Bianchi
BACKGROUND: Ultrasound and Power Doppler (PD) ultrasound are useful tools to study and monitor Hidradenitis Suppurativa (HS) patients. OBJECTIVE: Describe the Power Doppler signal of HS nodules, abscesses, fistulas. METHODS: A retrospective analysis of PD in mild, moderate, severe HS patients, collecting all demographic and clinical data. The lesions were classified according to their ultrasound morphology, describing the vascular degree - high, moderate, minimal - and distribution - peripheral, internal, mixed...
December 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29222438/new-insights-into-the-mechanism-of-nickel-superoxide-degradation-from-studies-of-model-peptides
#15
Daniel Tietze, Jana Sartorius, Banabithi Koley Seth, Kevin Herr, Pascal Heimer, Diana Imhof, Doreen Mollenhauer, Gerd Buntkowsky
A series of small, catalytically active metallopeptides, which were derived from the nickel superoxide dismutase (NiSOD) active site were employed to study the mechanism of superoxide degradation especially focusing on the role of the axial imidazole ligand. In the literature, there are contradicting propositions about the catalytic importance of the N-terminal histidine. Therefore, we studied the stability and activity of a set of eight NiSOD model peptides, which represent the major model systems discussed in the literature to date, yet differing in their length and their Ni-coordination...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29212560/concurrent-benzodiazepine-use-in-older-adults-treated-with-antidepressants-in-asia
#16
Xiao-Mei Zhong, Fei Wang, Qinge Zhang, Gabor S Ungvari, Chee H Ng, Helen F K Chiu, Tian-Mei Si, Kang Sim, Ajit Avasthi, Sandeep Grover, Mian-Yoon Chong, Kok-Yoon Chee, Shigenobu Kanba, Min-Soo Lee, Shu-Yu Yang, Pichet Udomratn, Roy A Kallivayalil, Andi J Tanra, Margarita M Maramis, Winston W Shen, Norman Sartorius, Rathi Mahendran, Chay-Hoon Tan, Naotaka Shinfuku, Yu-Tao Xiang
BACKGROUND: Little is known about the combined use of benzodiazepines and antidepressants in older psychiatric patients. This study examined the prescription pattern of concurrent benzodiazepines in older adults treated with antidepressants in Asia, and explored its demographic and clinical correlates. METHODS: The data of 955 older adults with any type of psychiatric disorders were extracted from the database of the Research on Asian Psychotropic Prescription Patterns for Antidepressants (REAP-AD) project...
December 7, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/29193708/teachers-of-psychiatry-meeting-in-chengdu
#17
Li Yuanyuan, Norman Sartorius, Helen Herrman, Chong Mian-Yoon, Tao Li, Huang Yi, Kua Ee Heok
No abstract text is available yet for this article.
December 2017: Asia-Pacific Psychiatry: Official Journal of the Pacific Rim College of Psychiatrists
https://www.readbyqxmd.com/read/29188733/investigational-drugs-in-clinical-trials-for-hidradenitis-suppurativa
#18
Peter Theut Riis, Linnea R Thorlacius, Gregor B Jemec
Hidradenitis suppurativa is a chronic skin disease with a significant unmet need for treatment options. Randomized controlled trials are few and only a single drug (adalimumab) has Hidradenitis as a registered indication. Areas covered: The clinicaltrials.gov and the EudraCT clinical trials register for reported trials on Hidradenitis Suppurativa was searched on the 22-06-2017. Trials for upcoming new drugs for HS are reported focusing on drugs in phase I and II trials. Expert opinion: Currently, MABp1, Secukinumab, CJM112, Apremilast and IFX-1 are being investigated in Phase I and II trials and offer theoretical and promising new treatment options...
December 4, 2017: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/29177540/the-distance-of-the-gluteal-nerve-in-relation-to-anatomical-landmarks-an-anatomic-study
#19
David Putzer, Matthias Haselbacher, Romed Hörmann, Martin Thaler, Michael Nogler
INTRODUCTION: Gluteal insufficiency is of concern with lateral approaches to total hip arthroplasty. Damage to the branches of the superior gluteal nerve may cause degeneration of the innervated muscles. The direct anterior approach exploits the intermuscular and internerval interval between tensor fasciae latae laterally and sartorius and rectus femoris muscle medially. In this study, the distance of the superior gluteal nerve in relation to anatomical landmarks was determined. MATERIALS AND METHODS: Two experienced surgeons implanted trial components in 15 alcohol glycerol fixed cadavers with 30 hips...
November 25, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29170812/avulsion-fracture-of-an-ossified-pes-anserinus-tendon-post-lateral-patellar-dislocation
#20
Omar M Albtoush, Abtehag A Taib, Marius Horger, Fabian Springer
The pes anserinus is a common tendon comprising the tendinous insertions of the sartorius, gracilis, and semitendinosus muscles. It inserts at the anteromedial aspect of the tibia and plays a significant role in stabilization of the medial side of the knee joint. The current article presents a case with recurrent lateral patellar dislocations causing chronic stress along the medial knee stabilizers and consecutive enthesophyte formation at the insertion of the pes anserinus tendon that showed a transverse fracture upon a subsequent incident of traumatic lateral patellar dislocation...
November 23, 2017: Skeletal Radiology
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