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Kamini Rajaratnam, Yu-Tao Xiang, Adarsh Tripathi, Helen Fung Kum Chiu, Tian-Mei Si, Kok-Yoon Chee, Ajit Avasthi, Sandeep Grover, Mian-Yoon Chong, Hironori Kuga, Shigenobu Kanba, Yan-Ling He, Min-Soo Lee, Shu-Yu Yang, Pichet Udomratn, Roy Abraham Kallivayalil, Andi J Tanra, Margarita Maramis, Winston Wu-Dien Shen, Norman Sartorius, Ee-Heok Kua, Chay-Hoon Tan, Rathi Mahendran, Naotaka Shinfuku, Min Yi Sum, Ross J Baldessarini, Kang Sim
In this study, we sought to examine factors associated with dosing of antidepressants (ADs) in Asia. Based on reported data and clinical experience, we hypothesized that doses of ADs would be associated with demographic and clinical factors and would increase over time. This cross-sectional, pharmacoepidemiological study analyzed data collected within the Research Study on Asian Psychotropic Prescription Pattern for Antidepressants from 4164 participants in 10 Asian countries, using univariate and multivariate methods...
October 5, 2016: Journal of Clinical Psychopharmacology
Y M Zheng, W Z Li, Z X Wang, W Zhang, H Lv, J X Xiao, Y Yuan
OBJECTIVE: To report thigh muscle magnetic resonance imaging (MRI) tests of four Chinese patients with dystrophinopathy with edema changes in adductor longus muscles that mimics adductor enthesopathy. METHODS: Four boys, who were from four unrelated families and aged from 5 to 11 years, were investigated because of the clinical manifestations including myalgia or muscle weakness or the incidental findings of elevated serum creatine kinase levels, and were diagnosed with dystrophinopathy by gene test of Duchenne muscular dystrophy (DMD)...
October 18, 2016: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
Jan Schulte, Thomas Sartorius, Johannes Weitenberg, Andreas Vernaleken, Peter Russbueldt
We demonstrate a scheme for nonlinear pulse compression at high average powers based on self-phase modulation in a multi-pass cell using fused silica as the nonlinear medium. The scheme is suitable for compression of pulses with peak powers exceeding the threshold for critical self-focusing. At >400  W of input power, the pulses of a Yb:YAG-Innoslab laser system (10 MHz repetition rate, 850 fs pulse duration) are spectrally broadened from 1.6 to >13.5  nm bandwidth while maintaining almost diffraction-limited beam quality...
October 1, 2016: Optics Letters
Markus Sack, Jenny N Lenz, Mira Jakovcevski, Sarah V Biedermann, Claudia Falfán-Melgoza, Jan Deussing, Maximilian Bielohuby, Martin Bidlingmaier, Frederik Pfister, Günter K Stalla, Alexander Sartorius, Peter Gass, Wolfgang Weber-Fahr, Johannes Fuss, Matthias K Auer
Excessive intake of high-caloric diets as well as subsequent development of obesity and diabetes mellitus may exert a wide range of unfavorable effects on the central nervous system (CNS) in the long-term. The potentially harmful effects of such diets were suggested to be mitigated by physical exercise. Here, we conducted a study investigating early effects of a cafeteria-diet on gray and white brain matter volume by means of voxel-based morphometry (VBM) and region-of-interest (ROI) analysis. Half of the mice performed voluntary wheel running to study if regular physical exercise prevents unfavorable effects of a cafeteria-diet...
October 12, 2016: Brain Imaging and Behavior
K Sartorius, B Sartorius, P S Govender, V Sharma, A Sherriff
The exponential rise in cancer costs in South Africa (SA) was illustrated in a recent Sunday Times article entitled 'The cost of cancer can be a debt sentence'. Our Minister of Health talks of a 'war' against the high costs of cancer drugs, and epidemiologists project a sharply rising incidence. Eminent international medical journals, such as The Lancet, underline the fact that cancer cost is a growing international problem that confronts even the richest countries. If richer countries in the world are battling to cover the costs of cancer, what is the prognosis for SA?...
September 6, 2016: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
Heather M Brechbuhl, Jessica Finlay-Schultz, Tomomi Yamamoto, Austin Gillen, Diana M Cittelly, Aik-Choon Tan, Sharon B Sams, Manoj Pillai, Anthony Elias, William A Robinson, Carol A Sartorius, Peter Kabos
PURPOSE: Anti-endocrine therapy remains the most effective treatment for ER+ breast cancer, but development of resistance is a major clinical complication. Effective targeting of mechanisms that control the loss of ER dependency in breast cancer remains elusive. We analyzed breast cancer-associated fibroblasts (CAFs), the largest component of the tumor microenvironment, as a factor contributing to ER expression levels and anti-endocrine resistance. EXPERIMENTAL DESIGN: Tissues from ER+ breast cancer patients were analyzed for the presence of CD146 positive (CD146pos) and CD146 negative (CD146neg) fibroblasts...
October 4, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Peter Theut Riis, Jurr Boer, Errol P Prens, Ditte M L Saunte, Inge E Deckers, Lennart Emtestam, Karin Sartorius, Gregor B E Jemec
BACKGROUND: Hidradenitis suppurativa (HS) is a chronic inflammatory disease of the hair follicle. Standard practice of managing acute flares with corticosteroid injection lacks scientific evidence. OBJECTIVE: We sought to assess the outcomes of routine treatment using intralesional triamcinolone (triamcinolone acetonide 10 mg/mL) in the management of acute flares in HS. METHODS: This was a prospective case series evaluating the effect of intralesional corticosteroids for alleviation of acute flares in HS...
September 28, 2016: Journal of the American Academy of Dermatology
Hidehiko Yoshimatsu, Takumi Yamamoto, Akitatsu Hayashi, Takuya Iida
BACKGROUND: Most authors elevate the superficial circumflex iliac artery perforator flap from the lateral edge of the skin paddle, and begin by dissecting a perforator perfusing the skin paddle. In this article, the authors introduce a modified technique for elevation of a superficial circumflex iliac artery perforator flap, beginning with identification of the pedicle arteries, allowing inclusion of a variety of anatomical structures. METHODS: From August of 2012 to August of 2015, 27 patients with soft- and bony-tissue defects underwent reconstruction using proximal-to-distally elevated superficial circumflex iliac artery perforator flaps...
October 2016: Plastic and Reconstructive Surgery
Kiran Polavarapu, Mahadevappa Manjunath, Veeramani Preethish-Kumar, Deepha Sekar, Seena Vengalil, PriyaTreesa Thomas, Talakad N Sathyaprabha, Rose Dawn Bharath, Atchayaram Nalini
The purpose of this study was to describe the pattern of muscle involvement using MRI findings and correlate with functional as well as muscle strength measurements. Fifty genetically confirmed DMD children with a mean age of 7.6 ± 2.8 (4-15 years) underwent muscle MRI and qualitative assessment was done for muscle changes using Mercuri staging for fibro-fatty replacement on T1 sequence and Borsato score for myoedema on STIR sequence. Detailed phenotypic characterisation was done with Manual muscle testing (modified MRC grading) and Muscular Dystrophy Functional Rating Scale (MDFRS)...
September 5, 2016: Neuromuscular Disorders: NMD
B Shazi, J L Bruce, G L Laing, B Sartorius, D L Clarke
INTRODUCTION The purpose of this study was to audit our current management of colonic trauma, and to review our experience of colonic trauma in patients who underwent initial damage control (DC) surgery. METHODS All patients treated for colonic trauma between January 2012 and December 2014 by the Pietermaritzburg Metropolitan Trauma Service were included in the study. Data reviewed included mechanism of injury, method of management (primary repair [PR], primary diversion [PD] or DC) and outcome (complications and mortality rate)...
September 23, 2016: Annals of the Royal College of Surgeons of England
S V Biedermann, J M Bumb, T Demirakca, G Ende, A Sartorius
OBJECTIVE: Electroconvulsive therapy (ECT) is a highly effective and well-tolerated therapy for severe and treatment-resistant depression. Cognitive side-effects are still feared by some patients and clinicians. Importantly, cognitive impairments are among the most disabling symptoms of depression itself. METHODS: Patients suffering from a severe episode of depression were treated with either ECT or treatment as usual (TAU) in an in-patient setting. Matched healthy participants served as controls (HC)...
September 23, 2016: Acta Psychiatrica Scandinavica
Juan Miguel Rodríguez-Roiz, Guillem Bori, Xavier Tomas, Jenaro A Fernández-Valencia, Ana Isabel García-Díez, Jaume Pomés, Sebastián Garcia
INTRODUCTION: Hypertrophy of the tensor fascia lata muscle (HTFLM) is a rare complication after total hip arthroplasty (THA) and is a potential source of pain, palpable mass, or both. MATERIALS AND METHODS: We retrospectively analyzed 1285 primary THAs and 482 THA revisions (THAR) performed at our center from 2008 to 2014. Among these, five patients had HTFLM (average age 68.8 years). The type of surgery and symptoms were evaluated, as were imaging studies (CT or MRI) of both hips (10 hips), and functional outcomes with the Merle d'Aubigné score...
September 19, 2016: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
Claudia Godi, Alessandro Ambrosi, Francesca Nicastro, Stefano C Previtali, Corrado Santarosa, Sara Napolitano, Antonella Iadanza, Marina Scarlato, Maria Grazia Natali Sora, Andrea Tettamanti, Simonetta Gerevini, Maria Pia Cicalese, Clementina Sitzia, Massimo Venturini, Andrea Falini, Roberto Gatti, Fabio Ciceri, Giulio Cossu, Yvan Torrente, Letterio S Politi
OBJECTIVE: The aim of this study was to evaluate the usefulness of magnetic resonance imaging (MRI) in detecting the progression of Duchenne muscular dystrophy (DMD) by quantification of fat infiltration (FI) and muscle volume index (MVI, a residual-to-total muscle volume ratio). METHODS: Twenty-six patients (baseline age: 5-12 years) with genetically proven DMD were longitudinally analyzed with lower limb 3T MRI, force measurements, and functional tests (Gowers, 10-m time, North Star Ambulatory Assessment, 6-min walking test)...
August 2016: Annals of Clinical and Translational Neurology
Tivani P Mashamba-Thompson, Benn Sartorius, Paul K Drain
Improving maternal health is a global priority, particularly in high HIV-endemic, resource-limited settings. Failure to use health care facilities due to poor access is one of the main causes of maternal deaths in South Africa. "Point-of-care" (POC) diagnostics are an innovative healthcare approach to improve healthcare access and health outcomes in remote and resource-limited settings. In this review, POC testing is defined as a diagnostic test that is carried out near patients and leads to rapid clinical decisions...
August 31, 2016: Diagnostics
Tina Sartorius, Anita M Hennige, Andreas Fritsche, Hans-Ulrich Häring
AIMS: Recent studies have identified unique brain effects of insulin detemir (Levemir®). Due to its pharmacologic properties, insulin detemir may reach higher concentrations in the brain than regular insulin. This might explain the observed increased brain stimulation after acute insulin detemir application but it remained unclear whether chronic insulin detemir treatment causes alterations in brain activity as a consequence of overstimulation. METHODS: In mice, we examined insulin detemir's prolonged brain exposure by continuous subcutaneous (s...
2016: PloS One
Raju Vaishya, Amit Kumar Agarwal, Nishint Gupta, Vipul Vijay
Avascular necrosis (AVN) of femoral head needs to be addressed early in the course of the disease, to prevent progression to osteoarthritis. A revascularizing procedure which can help preserve the head should be considered in young adults to alleviate the need for total hip arthroplasty. We included 40 cases (53 hips) of AVN of femoral head operated with Sartorius muscle pedicle iliac bone grafting, done by the senior author. Early post-operative rehabilitation was done. The weight bearing was delayed for 6 weeks...
August 2016: Journal of Hip Preservation Surgery
Nicholas C D'Amato, Michael A Gordon, Beatrice Babbs, Nicole S Spoelstra, Kiel T Carson Butterfield, Kathleen C Torkko, Vernon T Phan, Valerie N Barton, Thomas J Rogers, Carol A Sartorius, Anthony Elias, Jason Gertz, Britta M Jacobsen, Jennifer K Richer
: Androgen receptor (AR) is expressed in 90% of estrogen receptor alpha positive (ER+) breast tumors, but its role in tumor growth and progression remains controversial. Use of two anti-androgens that inhibit AR nuclear localization, enzalutamide and MJC13, revealed that AR is required for maximum ER genomic binding. Here, a novel global examination of AR chromatin binding found that estradiol induced AR binding at unique sites compared to dihydrotestosterone (DHT). Estradiol-induced AR binding sites were enriched for estrogen response elements and had significant overlap with ER binding sites...
August 26, 2016: Molecular Cancer Research: MCR
Andrew P Murdoch, Sam N Greenaway, Laura J Owen, Alan Danielski
OBJECTIVES: To confirm the anatomic location of the cranial cutaneous branch of the saphenous artery (CCSA), delineate the angiosome of the CCSA, and provide guidelines for clinical use of an axial pattern flap based on the CCSA. STUDY DESIGN: Anatomic study. ANIMALS: Greyhound cadavers (n=10). METHODS: Shortly after euthanasia, the CCSA was identified and isolated in each hindlimb. Methylene blue and radiographic perfusion studies were performed...
October 2016: Veterinary Surgery: VS
Junjun Zheng, Shuyun Chen, Yunqing Chen, Min Zhu, Daojun Hong
Mutations in the LDB3 gene have been identified in patients with Z-disc-associated, alternatively spliced, PDZ motif-containing protein (ZASP)-related myofibrillar myopathy (ZASP-MFM) characterized by late-onset distal myopathy with signs of cardiomyopathy and neuropathy. We describe an autosomal dominant inherited pedigree with ZASP-MFM that is in line with the typical phenotype of distal myopathy without cardiomyopathy and neuropathy, while mild asymmetrical muscle atrophy can be observed in some affected members...
August 21, 2016: Neuropathology: Official Journal of the Japanese Society of Neuropathology
Edoardo Malfatti, Christine Barnerias, Carola Hedberg-Oldfors, Cyril Gitiaux, Audrey Benezit, Anders Oldfors, Robert-Yves Carlier, Susana Quijano-Roy, Norma B Romero
Glycogen storage disease type IV (GSD IV) is an autosomal recessive disorder causing polyglucosan storage in various tissues. Neuromuscular forms present with fetal akinesia deformation sequence, lethal myopathy, or mild hypotonia and weakness. A 3-year-old boy presented with arthrogryposis, motor developmental delay, weakness, and rigid spine. Whole body MRI revealed fibroadipose muscle replacement but sparing of the sartorius, gracilis, adductor longus and vastus intermedialis muscles. Polyglucosan bodies were identified in muscle, and GBE1 gene analysis revealed two pathogenic variants...
October 2016: Neuromuscular Disorders: NMD
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