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https://www.readbyqxmd.com/read/28809619/the-effect-of-hiv-status-on-clinical-outcomes-of-surgical-sepsis-in-kwazulu-natal-province-south-africa
#1
Samantha Green, Victor Y Kong, Jocinta Odendaal, Benn Sartorius, Damian L Clarke, Petra Brysiewicz, Jereme L Bruce, Grant L Laing, Wanda Bekker
BACKGROUND: KwaZulu-Natal Province, South Africa (SA), has long been the epicentre of the HIV epidemic, but the impact of HIV co-infection on the clinical outcomes of emergency surgical patients with sepsis remains largely unknown. OBJECTIVE: To review our experience with the management of patients with HIV co-infection and to compare the disease spectrum and outcome with those without HIV infection. METHODS: A retrospective study was undertaken at the Pietermaritzburg Metropolitan Surgical Service (PMSS), SA over a 5-year period from January 2010 to December 2014...
July 28, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28804634/muscle-mri-findings-in-a-one-year-old-girl-with-merosin-deficient-congenital-muscular-dystrophy-type-1a-due-to-lama2-mutation-a-case-report
#2
Yingyin Liang, Guidian Li, Songlin Chen, Rongxing He, Xiangxue Zhou, Yingming Chen, Xue Xu, Ronglan Zhu, Cheng Zhang
The objective of the present study was to characterize the muscle magnetic resonance imaging (MRI) features of a 1-year-old girl with merosin-deficient congenital muscular dystrophy type 1A (MDC1A). Beginning as an infant, this patient exhibited severe hypotonia and proximal weakness, as well as delays in developmental milestones. Her serum creatine kinase levels at 3 months, 8 months and 1 year were 2,959, 1,621 and 1,659 U/l, respectively. Brain MRI indicated symmetric, mild T1WI low, mild T2WI and FLAIR high radial patterns in the white matter of the Cornu posterius of the ventricular lateral...
August 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28791439/metabolic-crosstalk-between-fatty-pancreas-and-fatty-liver-effects-on-local-inflammation-and-insulin-secretion
#3
Felicia Gerst, Robert Wagner, Gabriele Kaiser, Madhura Panse, Martin Heni, Jürgen Machann, Malte N Bongers, Tina Sartorius, Bence Sipos, Falko Fend, Christian Thiel, Silvio Nadalin, Alfred Königsrainer, Norbert Stefan, Andreas Fritsche, Hans-Ulrich Häring, Susanne Ullrich, Dorothea Siegel-Axel
AIMS/HYPOTHESIS: Obesity-linked ectopic fat accumulation is associated with the development of type 2 diabetes. Whether pancreatic and liver steatosis impairs insulin secretion is controversial. We examined the crosstalk of human pancreatic fat cells with islets and the role of diabetogenic factors, i.e. palmitate and fetuin-A, a hepatokine released from fatty liver. METHODS: Human pancreatic resections were immunohistochemically stained for insulin, glucagon, somatostatin and the macrophage/monocyte marker CD68...
August 8, 2017: Diabetologia
https://www.readbyqxmd.com/read/28790478/entrapment-neuropathy-of-the-infrapatellar-branch-of-the-saphenous-nerve-treated-by-partial-division-of-sartorius
#4
Gururaj Hosahalli, Adam Sierakowski, Hari Venkatramani, S Raja Sabapathy
We describe a case of entrapment neuropathy of the infrapatellar branch of the saphenous nerve as it pierces sartorius muscle. This is a rare cause of anteromedial knee pain that is easily overlooked and may be mistaken as arising from other anatomical structures in that region. The pain was successfully treated by partially dividing the sartorius muscle and translocating the nerve away from the site of entrapment. It is important to consider entrapment neuropathy of the infrapatellar branch of the saphenous nerve as a differential diagnosis when assessing a patient with anteromedial knee pain...
July 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/28789998/does-hip-joint-positioning-affect-maximal-voluntary-contraction-in-the-gluteus-maximus-gluteus-medius-tensor-fasciaelatae-and-sartorius-muscles
#5
Jules Bernard, Julien Beldame, Stéphane Van Driessche, Helena Brunel, Thomas Poirier, Patrice Guiffault, Jean Matsoukis, Fabien Billuart
BACKGROUND: Minimally invasive total hip arthroplasty (THA) is presumed to provide functional and clinical benefits, whereas in fact the literature reveals that gait and posturographic parameters following THA do not recover values found in the general population. There is a significant disturbance of postural sway in THA patients, regardless of the surgical approach, although with some differences between approaches compared to controls: the anterior and anterolateral minimally invasive approaches seem to be more disruptive of postural parameters than the posterior approach...
August 5, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28768208/autobiographical-memory-deficits-in-patients-with-depression-follow-a-temporal-distribution
#6
Sarah V Biedermann, Traute Demirakca, Alexander Sartorius, Matthias K Auer, Gabriele Ende, Fabrice Berna
Autobiographical memory deficits are known in depression. The temporal distribution thereof across periods of life has rarely been considered yet. Autobiographical memories for 5 life periods were investigated in 27 depressed in-patients and compared to 31 matched healthy controls using the Bielefelder Autobiographisches Gedächtnis Inventar. Depressed patients reported significantly less details in memories dating from childhood to 30 years, correlating with severity of depression. Memories from childhood and recent periods were less positive in depressed patients...
July 26, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28765683/the-current-situations-and-needs-of-mental-health-in-china
#7
EDITORIAL
Norman Sartorius
No abstract text is available yet for this article.
April 25, 2017: Shanghai Archives of Psychiatry
https://www.readbyqxmd.com/read/28761699/high-intensity-flywheel-exercise-and-recovery-of-atrophy-after-90-days-bed-rest
#8
Daniel L Belavý, Hiroshi Ohshima, Jörn Rittweger, Dieter Felsenberg
AIMS: To investigate differential muscle atrophy during bed-rest, the impact of a high-intensity concentric-eccentric (flywheel) resistance exercise countermeasure and muscle recovery after bed-rest. METHODS: Twenty-five healthy male subjects underwent 90 dayshead-down tilt bed-rest. Volume of individual lower-limb muscles was measured via MRI before, twice during and four times up to 1 year after bed-rest. Subjects were either inactive (n=16) or performed flywheel exercise every third day of bed-rest (n=9)...
2017: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/28737081/hypotension-of-%C3%A2-110-mmhg-is-associated-with-increased-mortality-in-south-african-patients-after-trauma
#9
D L Clarke, P Brysiewicz, B Sartorius, J L Bruce, G L Laing
INTRODUCTION: This study used data from a prospectively maintained trauma database to assess the level of systolic blood pressure at which mortality rates for trauma begin to increase and to compare systolic blood pressure with base deficit as a predictor of outcome. METHODOLOGY: The Pietermaritzburg Metropolitan Trauma Service maintains a prospective digital trauma registry. All trauma patients admitted to the service for the period January 2012-January 2015 were included...
March 1, 2017: Scandinavian Journal of Surgery: SJS
https://www.readbyqxmd.com/read/28729413/breast-cancer-suppression-by-progesterone-receptors-is-mediated-by-their-modulation-of-estrogen-receptors-and-rna-polymerase-iii
#10
Jessica Finlay-Schultz, Austin E Gillen, Heather M Brechbuhl, Joshua J Ivie, Shawna B Matthews, Britta M Jacobsen, David L Bentley, Peter Kabos, Carol A Sartorius
Greater than 50% of estrogen receptor (ER)-positive breast cancers co-express the progesterone receptor (PR), which can directly and globally modify ER action to attenuate tumor growth. However, whether this attenuation is mediated only through PR-ER interaction remains unknown. To address this question, we assessed tumor growth in ER/PR-positive PDX models of breast cancer where both natural and synthetic progestins were found to antagonize the mitogenic effects of estrogens. Probing the genome-wide mechanisms by which this occurs, we documented that chronic progestin treatment blunted ER-mediated gene expression up to 2-fold at the level of mRNA transcripts...
July 20, 2017: Cancer Research
https://www.readbyqxmd.com/read/28714751/antidepressant-efficacy-of-electroconvulsive-therapy-is-associated-with-a-reduction-of-the-innate-cellular-immune-activity-in-the-cerebrospinal-fluid-in-patients-with-depression
#11
Laura Kranaster, Carolin Hoyer, Suna S Aksay, J Malte Bumb, Norbert Müller, Peter Zill, Markus J Schwarz, Alexander Sartorius
OBJECTIVES: A bidirectional link between the antidepressant effects of electroconvulsive therapy (ECT) and the modulation of the immune system has been proposed. To elucidate the interplay between antidepressant treatment and macrophage/microglia activation in humans, we performed a study on the effects of the antidepressant treatment by ECT on markers of macrophage/microglia activation in patients with depression. METHODS: We measured six different markers (IL-6, neopterin, sCD14, sCD163 MIF and MCP1) of macrophage/microglia activation in the cerebrospinal fluid (CSF) and blood of 12 patients with a severe, treatment-resistant depressive episode before and after a course of ECT...
July 17, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28694350/prevalence-of-metabolic-syndrome-discrete-or-comorbid-diabetes-and-hypertension-in-sub-saharan-africa-among-people-living-with-hiv-versus-hiv-negative-populations-a-systematic-review-and-meta-analysis-protocol
#12
Olamide O Todowede, Benn Sartorius
INTRODUCTION: Metabolic disorder and high blood pressure are common complications globally, and specifically among people living with HIV (PLHIV). Diabetes, metabolic syndrome and hypertension are major risk factors for cardiovascular diseases and their related complications. However, the burden of metabolic syndrome, discrete or comorbid diabetes and hypertension in PLHIV compared with HIV-negative population has not been quantified. This review and meta-analysis aims to compare and analyse the prevalence of these trio conditions between HIV-negative and HIV-positive populations in sub-Saharan Africa (SSA)...
July 9, 2017: BMJ Open
https://www.readbyqxmd.com/read/28692043/cross-talk-between-progesterone-receptors-and-retinoic-acid-receptors-in-regulation-of-cytokeratin-5-positive-breast-cancer-cells
#13
L M Fettig, O McGinn, J Finlay-Schultz, D V LaBarbera, S K Nordeen, C A Sartorius
Half of estrogen receptor-positive breast cancers contain a subpopulation of cytokeratin 5 (CK5)-expressing cells that are therapy resistant and exhibit increased cancer stem cell (CSC) properties. We and others have demonstrated that progesterone (P4) increases CK5+ breast cancer cells. We previously discovered that retinoids block P4 induction of CK5+ cells. Here we investigated the mechanisms by which progesterone receptors (PR) and retinoic acid receptors (RAR) regulate CK5 expression and breast CSC activity...
July 10, 2017: Oncogene
https://www.readbyqxmd.com/read/28684079/a-comparison-of-base-deficit-and-vital-signs-in-the-early-assessment-of-patients-with-penetrating-trauma-in-a-high-burden-setting
#14
Mark Peter Dunham, Benn Sartorius, Grant Llewellyn Laing, John Lambert Bruce, Damian Luiz Clarke
INTRODUCTION: An assessment of physiological status is a key step in the early assessment of trauma patients with implications for triage, investigation and management. This has traditionally been done using vital signs. Previous work from large European trauma datasets has suggested that base deficit (BD) predicts clinically important outcomes better than vital signs (VS). A BD derived classification of haemorrhagic shock appeared superior to one based on VS derived from ATLS criteria in a population of predominantly blunt trauma patients...
June 20, 2017: Injury
https://www.readbyqxmd.com/read/28660809/the-effect-of-stage-of-hiv-disease-as-determined-by-cd4-count-on-clinical-outcomes-of-surgical-sepsis-in-south-africa
#15
S Green, V Y Kong, G L Laing, J L Bruce, J Odendaal, B Sartorius, D L Clarke
INTRODUCTION This paper reviews the impact of the stage of human immunodeficiency virus (HIV) disease on the outcome of surgical sepsis. METHODS All adult emergency general surgical patients (aged >15 years) who fulfilled the criteria for sepsis or septic shock, with a documented surgical source of infection, and who were HIV positive were reviewed. RESULTS During the 5-year study period, a total of 675 patients with a documented surgical source of sepsis were managed by our service; 142 (21%) of these were HIV positive...
July 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/28658998/patient-reported-outcomes-in-topical-field-treatment-of-actinic-keratosis-in-swedish-and-danish-patients
#16
Hanna Norrlid, Jenny M Norlin, Heidi Holmstrup, Irena Malmberg, Karin Sartorius, Henrik Thormann, Gregor B E Jemec, Gunnel Ragnarson Tennvall
Topical treatments in dermatology can be long, complex and lead to nonadherence and nonpersistence to prescribed treatment. Clinical efficacy observed in randomized clinical trials (RCT) may therefore be reduced in real-world clinical practice. The objective of this study was to analyze patient-reported treatment adherence, treatment satisfaction and health-related quality of life (HRQoL) with topical treatments of actinic keratosis (AK) in routine clinical practice in Denmark and Sweden. Adult patients prescribed field-directed topical AK treatments with diclofenac gel, imiquimod or ingenol mebutate per routine clinical practice were eligible for the observational RAPID-ACT study...
June 29, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28649793/characteristics-of-acute-groin-injuries-in-the-hip-flexor-muscles-a-detailed-mri-study-in-athletes
#17
Andreas Serner, Adam Weir, Johannes L Tol, Kristian Thorborg, Frank Roemer, Ali Guermazi, Eduardo Yamashiro, Per Hölmich
Hip flexor injuries account for one third of acute groin injuries; however, little is known about specific injury characteristics. The aims of this study was to describe acute hip flexor injuries using magnetic resonance imaging (MRI) in athletes with acute groin pain, and to compare specific muscle injuries with reported injury situations. Male athletes with acute groin pain were prospectively and consecutively included during 3 sports seasons. MRI was performed within 7 days of injury using a standardized protocol and a reliable assessment approach...
June 26, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28637942/clinical-characteristics-and-psychotropic-prescribing-patterns-associated-with-impaired-concentration-in-asians-with-depressive-disorders-the-reap-ad-study
#18
Seon-Cheol Park, Min-Soo Lee, Sang Woo Hahn, Shigenobu Kanba, Mian-Yoon Chong, Kok Yoon Chee, Pichet Udomratn, Adarsh Tripathi, Norman Sartorius, Naotaka Shinfuku, Andi J Tanra, Yong Chon Park
The Research on Asian Psychotropic Prescription Patterns for Antidepressants (REAP-AD) study aimed to survey and review antidepressant prescribing patterns in different clinical settings in Asian countries/areas. The REAP-AD study collected comprehensive data for psychiatric patients prescribed antidepressants in 10 Asian countries/areas during the period from March to June 2013. Depressive disorders have been an important issue closely associated with ill-health and disability in the realm of mental health...
June 2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28636793/development-and-validation-of-ihs4-a-novel-dynamic-scoring-system-to-assess-hidradenitis-suppurativa-acne-inversa-severity
#19
C C Zouboulis, T Tzellos, A Kyrgidis, G B E Jemec, F G Bechara, E J Giamarellos-Bourboulis, J R Ingram, T Kanni, I Karagiannidis, A Martorell, Ł Matusiak, A Pinter, E P Prens, D Presser, S Schneider-Burrus, E von Stebut, J C Szepietowski, H H van der Zee, S M Wilden, R Sabat
BACKGROUND: A validated tool for the dynamic severity assessment of hidradenitis suppurativa (HS) is lacking. The aim of this study was to develop and validate such a novel scoring system. METHODS: A Delphi voting procedure was conducted among the members of the European Hidradenitis Suppurativa Foundation (EHSF) to achieve consensus towards an initial HS Severity Score System (HS4). Strengths and weaknesses of HS4 were examined by a multicenter prospective study...
June 21, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28630219/a-rare-case-of-sigmoid-colon-perforation-with-subsequent-psoas-abscess-collection-with-extensive-involvement-of-the-sartorius-muscle
#20
Ali Wadood, Abdulrahman Odeh, Khizer Rana, Shafquat Zaman
A middle-aged man was admitted with worsening hip pain, fevers and reduced mobility. These symptoms were preceded by a mechanical fall but despite regular analgesia, symptoms did not resolve. His prior medical history included ischaemic heart disease, hypertension and hypercholesterolaemia. A trauma and orthopaedic review revealed a painful left hip with reduced range of motion. In addition, some mild tenderness in the left iliac fossa was noted. Blood tests revealed markedly raised inflammatory markers. Plain radiographs and ultrasound were normal...
June 19, 2017: BMJ Case Reports
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