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https://www.readbyqxmd.com/read/29053893/unilateral-faciobrachial-weakness-an-unusual-neuromuscular-presentation-of-west-nile-virus-infection
#1
Ahmed M El-Dokla, Rashedul Hasan, Sara T Ali
West Nile virus (WNV) first gained entry into North America in the New York City outbreak of 1999 and subsequently spread to other areas of the United States. (1) The clinical manifestations range from a mild febrile illness to West Nile neuroinvasive disease (WNND) characterized by meningitis, encephalitis and/or asymmetric flaccid paralysis (AFP). (2,3) However, patients with WNND may lack the classic clinical features of meningitis or encephalitis, which may confound the diagnosis. We describe 2 patients with WNND who presented with unilateral faciobrachial weakness without overt meningitis or encephalitis...
October 20, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/29053861/physical-function-following-a-long-term-lifestyle-intervention-among-middle-aged-and-older-adults-with-type-2-diabetes-the-look-ahead-study
#2
Denise K Houston, Rebecca H Neiberg, Michael E Miller, James O Hill, John M Jakicic, Karen C Johnson, Edward W Gregg, Van S Hubbard, Xavier Pi-Sunyer, W Jack Rejeski, Rena R Wing, John P Bantle, Elizabeth Beale, Robert I Berkowitz, Maria Cassidy-Begay, Jeanne M Clark, Mace Coday, Linda M Delahanty, Gareth Dutton, Caitlin Egan, John P Foreyt, Frank L Greenway, Helen P Hazuda, Andrea Hergenroeder, Edward S Horton, Robert W Jeffery, Steven E Kahn, Anne Kure, William C Knowler, Cora E Lewis, Corby K Martin, Sara Michaels, Maria G Montez, David M Nathan, Jennifer Patricio, Anne Peters, Henry Pownall, Judith Regensteiner, Helmut Steinburg, Thomas A Wadden, Karen White, Susan Z Yanovski, Ping Zhang, Stephen B Kritchevsky
Background: Lifestyle interventions have been shown to improve physical function over the short term; however, whether these benefits are sustainable is unknown. The long-term effects of an intensive lifestyle intervention on physical function were assessed using a randomized post-test design in the Look AHEAD trial. Methods: Overweight and obese (BMI ≥25 kg/m 2) middle-aged and older adults (aged 45-76 years at enrollment) with type 2 diabetes enrolled in Look AHEAD, a trial evaluating an intensive lifestyle intervention (ILI) designed to achieve weight loss through caloric restriction and increased physical activity compared to diabetes support and education (DSE), underwent standardized assessments of performance-based physical function including a 4- and 400-m walk, lower extremity physical performance (expanded Short Physical Performance Battery, SPPBexp), and grip strength approximately 11 years post-randomization and 1...
October 19, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29053820/mood-disorders-and-risk-of-herpes-zoster-in-two-population-based-case-control-studies-in-denmark-and-the-united-kingdom
#3
Sigrun A J Schmidt, Sinéad M Langan, Henrik S Pedersen, Henrik C Schønheyder, Sara L Thomas, Liam Smeeth, Kathryn E Mansfield, Henrik T Sørensen, Harriet J Forbes, Mogens Vestergaard
We examined the association between mood disorders and risk of herpes zoster in two case-control studies using data from nationwide Danish registries and practices in the UK Clinical Practice Research Datalink. We included incident zoster cases diagnosed in general practice (using systemic antivirals as proxy in Denmark) or hospital during 1997-2013 in Denmark (n = 190,671) and during 2000-2013 in the UK (n = 177,361). We risk-set sampled four matched population controls per case. Conditional logistic regression analyses adjusted for zoster risk factors showed that the odds ratios (ORs) for previous mood disorder among cases vs...
October 19, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29053791/pharmacological-targeting-of-apelin-impairs-glioblastoma-growth
#4
Elizabeth Harford-Wright, Gwennan Andre-Gregoire, Kathryn A Jacobs, Lucas Treps, Sophie Le Gonidec, Heloise M Leclair, Sara Gonzalez-Diest, Quentin Roux, François Guillonneau, Delphine Loussouarn, Lisa Oliver, François M Vallette, Fabienne Foufelle, Philippe Valet, Anthony P Davenport, Robert C Glen, Nicolas Bidere, Julie Gavard
Glioblastoma are highly aggressive brain tumours that are associated with an extremely poor prognosis. Within these tumours exists a subpopulation of highly plastic self-renewing cancer cells that retain the ability to expand ex vivo as tumourspheres, induce tumour growth in mice, and have been implicated in radio- and chemo-resistance. Although their identity and fate are regulated by external cues emanating from endothelial cells, the nature of such signals remains unknown. Here, we used a mass spectrometry proteomic approach to characterize the factors released by brain endothelial cells...
October 3, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29053726/prevalence-of-deleterious-germline-variants-in-risk-genes-including-brca1-2-in-consecutive-ovarian-cancer-patients-ago-tr-1
#5
Philipp Harter, Jan Hauke, Florian Heitz, Alexander Reuss, Stefan Kommoss, Frederik Marmé, André Heimbach, Katharina Prieske, Lisa Richters, Alexander Burges, Guido Neidhardt, Nikolaus de Gregorio, Ahmed El-Balat, Felix Hilpert, Werner Meier, Rainer Kimmig, Karin Kast, Jalid Sehouli, Klaus Baumann, Christian Jackisch, Tjoung-Won Park-Simon, Lars Hanker, Sandra Kröber, Jacobus Pfisterer, Heidrun Gevensleben, Andreas Schnelzer, Dimo Dietrich, Tanja Neunhöffer, Mathias Krockenberger, Sara Y Brucker, Peter Nürnberg, Holger Thiele, Janine Altmüller, Josefin Lamla, Gabriele Elser, Andreas du Bois, Eric Hahnen, Rita Schmutzler
BACKGROUND: Identification of families at risk for ovarian cancer offers the opportunity to consider prophylactic surgery thus reducing ovarian cancer mortality. So far, identification of potentially affected families in Germany was solely performed via family history and numbers of affected family members with breast or ovarian cancer. However, neither the prevalence of deleterious variants in BRCA1/2 in ovarian cancer in Germany nor the reliability of family history as trigger for genetic counselling has ever been evaluated...
2017: PloS One
https://www.readbyqxmd.com/read/29053490/paea-accreditation-task-force-briefing-paper-moving-toward-outcomes-based-accreditation
#6
Mary Jo Bondy, Sara Fletcher, Steven Lane
In anticipation of a revision to the Standards for Accreditation, the Phyisician Assistant Education Association (PAEA) charged a small task force to develop a strategy for engaging its members in the revision process. Rather than focusing on the current Standards, the task force members recommend a backward design approach to determine the desired outcomes of a successful revision to the Standards. Ultimately, the group believes that shifting to an outcomes-based model for accreditation will allow for greater innovation in physician assistant education and reduce the strain on programs facing resource limitations, particularly clinical site shortages...
October 19, 2017: Journal of Physician Assistant Education
https://www.readbyqxmd.com/read/29053438/tailored-approach-to-surgical-exposure-reduces-surgical-site-complications-after-bilateral-lung-transplantation
#7
Stefan Elde, Stephen Huddleston, Scott Jackson, Rosemary Kelly, Sara Shumway, Gabriel Loor
BACKGROUND: We evaluated the effects of tailoring the operative approach on major surgical site complications and outcomes in lung transplant recipients. PATIENTS AND METHODS: Beginning in July 2013, bilateral lung transplants at a single institution were performed either through sternotomy or clamshell depending on proximity of hilar structures by computed tomography (CT), anticipated complexity, past surgical history, and surgeon experience. Patient demographics and outcomes were collected in the institution's Transplant Information Services (TIS)...
October 20, 2017: Surgical Infections
https://www.readbyqxmd.com/read/29053175/distinct-pattern-of-tp53-mutations-in-human-immunodeficiency-virus-related-head-and-neck-squamous-cell-carcinoma
#8
Frederico O Gleber-Netto, Mei Zhao, Sanchit Trivedi, Jiping Wang, Samar Jasser, Christina McDowell, Humam Kadara, Jiexin Zhang, Jing Wang, William N William, J Jack Lee, Minh Ly Nguyen, Sara I Pai, Heather M Walline, Dong M Shin, Robert L Ferris, Thomas E Carey, Jeffrey N Myers, Curtis R Pickering
BACKGROUND: Human immunodeficiency virus-infected individuals (HIVIIs) have a higher incidence of head and neck squamous cell carcinoma (HNSCC), and clinical and histopathological differences have been observed in their tumors in comparison with those of HNSCC patients without a human immunodeficiency virus (HIV) infection. The reasons for these differences are not clear, and molecular differences between HIV-related HNSCC and non-HIV-related HNSCC may exist. This study compared the mutational patterns of HIV-related HNSCC and non-HIV-related HNSCC...
October 20, 2017: Cancer
https://www.readbyqxmd.com/read/29053055/successful-surgical-repair-and-recovery-in-a-2-week-old-infant-after-birth-related-cervical-fracture-dislocation
#9
Sara Saleh, Kyle I Swanson, Taryn Bragg
Cervical spine injuries are the most common spine injuries in the pediatric population. The authors present the youngest known patient who underwent cervical spine fusion to repair birth trauma-induced cervical fracture dislocation, resulting in spondyloptosis and spinal cord injury. A 2-week-old boy was found to have spondyloptosis and spinal cord injury after concerns arose from reduced movement of the extremities. The patient's birth was complicated by undiagnosed abdominal dystocia, which led to cervical distraction injury...
October 20, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29053037/possible-autoantibody-negative-limbic-encephalitis-after-anterior-temporal-lobectomy-for-hippocampal-sclerosis
#10
Sara Casciato, Alfredo D'Aniello, Addolorata Mascia, Pier Paolo Quarato, Marco De Risi, Liliana G Grammaldo, Vincenzo Esposito, Marco Zoccarato, Giancarlo Di Gennaro
Amnestic syndromes are acknowledged to be associated to bilateral hippocampal damage. We briefly report the case of a young man who underwent anterior left temporal lobectomy for a medically refractory temporal lobe epilepsy due to hippocampal sclerosis with an excellent seizure and neuropsychological outcome. Approximately 10 years later, he presented with a subacute severe global amnesia and MRI findings of a damage involving the contralateral mesial temporal lobe structures. A diagnosis of a possible autoimmune encephalitis was made...
October 20, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29052816/depressive-symptoms-predict-anti-tumor-necrosis-factor-therapy-noncompliance-in-patients-with-inflammatory-bowel-disease
#11
Alexis Calloway, Robin Dalal, Dawn B Beaulieu, Caroline Duley, Kimberly Annis, Lawrence Gaines, Chris Slaughter, David A Schwartz, Sara Horst
BACKGROUND: Noncompliance in use of anti-tumor necrosis factor (anti-TNF) therapy in patients with moderate-to-severe inflammatory bowel disease (IBD) can be a factor in medication failure. Few studies have evaluated the contribution of depressive symptoms to medication noncompliance in anti-TNF therapies. METHODS: A retrospective chart review was performed in a single-center tertiary care IBD center for patients with Crohn's disease and ulcerative colitis starting anti-TNF therapy over a 2-year period...
October 20, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29052513/a-method-to-reduce-ancestry-related-germline-false-positives-in-tumor-only-somatic-variant-calling
#12
Rebecca F Halperin, John D Carpten, Zarko Manojlovic, Jessica Aldrich, Jonathan Keats, Sara Byron, Winnie S Liang, Megan Russell, Daniel Enriquez, Ana Claasen, Irene Cherni, Baffour Awuah, Joseph Oppong, Max S Wicha, Lisa A Newman, Evelyn Jaigge, Seungchan Kim, David W Craig
BACKGROUND: Significant clinical and research applications are driving large scale adoption of individualized tumor sequencing in cancer in order to identify tumors-specific mutations. When a matched germline sample is available, somatic mutations may be identified using comparative callers. However, matched germline samples are frequently not available such as with archival tissues, which makes it difficult to distinguish somatic from germline variants. While population databases may be used to filter out known germline variants, recent studies have shown private germline variants result in an inflated false positive rate in unmatched tumor samples, and the number germline false positives in an individual may be related to ancestry...
October 19, 2017: BMC Medical Genomics
https://www.readbyqxmd.com/read/29052226/translational-high-dimensional-drug-interaction-discovery-and-validation-using-health-record-databases-and-pharmacokinetics-models
#13
Chien-Wei Chiang, Pengyue Zhang, Xueying Wang, Lei Wang, Shijun Zhang, Xia Ning, Li Shen, Sara K Quinney, Lang Li
Polypharmacy increases the risk of drug-drug interactions (DDI's). Combining epidemiological studies with pharmacokinetic modeling, we detected and evaluated high-dimensional DDI's among thirty frequent drugs. Multi-drug combinations that increased risk of myopathy were identified in the FDA Adverse Event Reporting System (FAERS) and electronic medical record (EMR) databases by a mixture drug-count response model. CYP450 inhibition was estimated among the 30 drugs in the presence of 1 to 4 inhibitors using in vitro in vivo extrapolation...
October 20, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29052147/pulsed-light-reduces-the-toxicity-of-the-algal-toxin-okadaic-acid-to-freshwater-crustacean-daphnia-pulex
#14
Iain M T Murray, Neil J Rowan, Sara McNamee, Katrina Campbell, Andrew M Fogarty
This constitutes the first study to report on the reduction in toxicity of the dinoflagellate algal toxin okadaic acid after novel pulsed light (PL) treatments where ecotoxicological assessment was performed using a miniaturised format of the conventional in vivo freshwater crustacean Daphnia sp. acute toxicity test. Bivalves accumulate this toxin, which can then enter the human food chain causing deleterious health effects such as diarrhetic shellfish poisoning. This miniaturised toxicological bioassay used substantially less sample volume and chemical reagents...
October 19, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29052067/concomitant-open-ventral-hernia-repair-what-is-the-financial-impact-of-performing-open-ventral-hernia-with-other-abdominal-procedures-concomitantly
#15
Vashisht Madabhushi, Margaret A Plymale, John Scott Roth, Sara Johnson, Alex Wade, Daniel L Davenport
BACKGROUND: Open ventral hernia repair (VHR) is often performed in conjunction with other abdominal procedures. Clinical outcomes and financial implications of VHR are becoming better understood; however, financial implications of concomitant VHR during other abdominal procedures are unknown. This study aimed to evaluate the financial implications of adding VHR to open abdominal procedures. METHODS: This IRB-approved study retrospectively reviewed hospital costs to 180-day post-discharge of standalone VHRs, isolated open abdominal surgeries (bowel resection or stoma closure, removal of infected mesh, hysterectomy or oophorectomy, panniculectomy or abdominoplasty, open appendectomy or cholecystectomy), performed at our institution from October 1, 2011 to September 30, 2014...
October 19, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29051543/cryoem-structure-of-saccharomyces-cerevisiae-u1-snrnp-offers-insight-into-alternative-splicing
#16
Xueni Li, Shiheng Liu, Jiansen Jiang, Lingdi Zhang, Sara Espinosa, Ryan C Hill, Kirk C Hansen, Z Hong Zhou, Rui Zhao
U1 snRNP plays a critical role in 5'-splice site recognition and is a frequent target of alternative splicing factors. These factors transiently associate with human U1 snRNP and are not amenable for structural studies, while their Saccharomyces cerevisiae (yeast) homologs are stable components of U1 snRNP. Here, we report the cryoEM structure of yeast U1 snRNP at 3.6 Å resolution with atomic models for ten core proteins, nearly all essential domains of its RNA, and five stably associated auxiliary proteins...
October 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/29051506/an-integrated-eeg-and-eye-tracking-approach-for-the-study-of-responding-and-initiating-joint-attention-in-autism-spectrum-disorders
#17
Lucia Billeci, Antonio Narzisi, Alessandro Tonacci, Beatrice Sbriscia-Fioretti, Luca Serasini, Francesca Fulceri, Fabio Apicella, Federico Sicca, Sara Calderoni, Filippo Muratori
Autism Spectrum Disorders (ASD) are characterised by impairment in joint attention (JA), which has two components: the response to JA and the initiation of JA. Literature suggests a correlation between JA and neural circuitries, although this link is still largely unexplored in ASD. In this pilot study, we aimed at investigating the neural correlates of responding and initiating JA in high-functioning children with ASD and evaluating the changes in brain function and visual pattern after six months of rehabilitative treatment using an integrated EEG/eye-tracking system...
October 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29051338/the-occurrence-of-cardiac-output-decrease-via-stroke-volume-is-more-pronounced-in-women-than-in-men-during-prolonged-dry-static-apnoea
#18
Sara Magnani, Gabriele Mulliri, Gianmarco Sainas, Giovanna Ghiani, Virginia Pinna, Irene Sanna, Antonio Crisafulli, Filippo Tocco
Little is known on gender differences in autonomic cardiovascular regulation of diving response (DR) and the few available studies into these differences were conducted on subjects with limited or no diving experience. We examined gender influence on hemodynamics during dry-static apnoea (SA) in 8 male and 8 female elite divers matched for their breath-hold (BH) ability. Hemodynamics was assessed by means of simultaneous echocardiography and impedance cardiography measurements and arterial pressure and oxygen saturation (SaO2) were also collected...
October 19, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29051274/effect-of-morphine-on-breathlessness-and-exercise-endurance-in-advanced-copd-a%C3%A2-randomised-crossover-trial
#19
Sara J Abdallah, Courtney Wilkinson-Maitland, Nathalie Saad, Pei Zhi Li, Benjamin M Smith, Jean Bourbeau, Dennis Jensen
The objective of the present study was to evaluate the effect of morphine on exertional breathlessness and exercise endurance in advanced chronic obstructive pulmonary disease (COPD).In a randomised crossover trial, we compared the acute effect of immediate-release oral morphine versus placebo on physiological and perceptual responses during constant-load cardiopulmonary cycle exercise testing (CPET) in 20 adults with advanced COPD and chronic breathlessness syndrome.Compared with placebo, morphine reduced exertional breathlessness at isotime by 1...
October 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29050918/assessing-the-effect-of-lifetime-contralateral-breast-cancer-risk-on-the-selection-of-contralateral-prophylactic-mastectomy-for-unilateral-breast-cancer
#20
John V Hegde, Xiaoyan Wang, Deanna J Attai, Maggie L DiNome, Amy Kusske, Anne C Hoyt, Sara A Hurvitz, Joanne B Weidhaas, Michael L Steinberg, Susan A McCloskey
INTRODUCTION: Contralateral prophylactic mastectomy (CPM) rates are rising, with fear implicated as a contributing factor. This study used a contralateral breast cancer (CBC) risk stratification tool to assess whether the selection of CPM is reflective of future CBC risk. PATIENTS AND METHODS: This retrospective study evaluated 404 women with unilateral breast cancer treated with breast conservation, unilateral mastectomy, or bilateral mastectomy within a single multidisciplinary clinic...
September 27, 2017: Clinical Breast Cancer
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