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https://www.readbyqxmd.com/read/27922981/second-opinion-expert-pathology-in-endometrial-cancer-potential-clinical-implications
#1
Friederike Grevenkamp, Felix Kommoss, Friedrich Kommoss, Sigurd Lax, Falko Fend, Diethelm Wallwiener, Birgitt Schönfisch, Bernhard Krämer, Sara Y Brucker, Florin-Andrei Taran, Annette Staebler, Stefan Kommoss
OBJECTIVE: In cancer patients, the pathology report serves as an important basis for treatment. Therefore, a correct cancer diagnosis is crucial, and diagnostic discrepancies may be of clinical relevance. It was the aim of this study to perform a specialized histopathology review and to investigate potential clinical implications of expert second opinion pathology in endometrial cancer. METHODS: Patients treated for endometrial carcinoma at the Tübingen University Women's hospital between 2003 and 2013 were identified...
December 3, 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27922843/persistent-breast-pain-among-women-with-histories-of-breast-conserving-surgery-for-breast-cancer-compared-with-women-without-histories-of-breast-surgery-or-cancer
#2
Sara N Edmond, Rebecca A Shelby, Francis J Keefe, Hannah M Fisher, John E Schmidt, Mary S Soo, Celette S Skinner, Gretchen M Ahrendt, Jessica Manculich, Jules H Sumkin, Margarita L Zuley, Dana H Bovbjerg
OBJECTIVES: This study compared persistent breast pain among women who received breast-conserving surgery for breast cancer and women without a history of breast cancer. METHODS: Breast cancer survivors (n=200) were recruited at their first postsurgical surveillance mammogram (6 to 15 mo postsurgery). Women without a breast cancer history (n=150) were recruited at the time of a routine screening mammogram. All women completed measures of breast pain, pain interference with daily activities and intimacy, worry about breast pain, anxiety symptoms, and depression symptoms...
January 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/27922701/elolyckor-kan-ge-skador-som-visar-sig-efter-l%C3%A3-ng-tid-det-akuta-omh%C3%A3-ndertagandet-kan-vara-avg%C3%A3-rande-p%C3%A3-sikt
#3
Martin Tondel, Anna Blomqvist, Kristina Jakobsson, Tohr Nilsson, Bodil Persson, Sara Thomée, Lars-Gunnar Gunnarsson
Immediate and delayed outcomes after electrical injury. A guide for clinicians In Sweden about 300 electrical injuries are recorded each year at the Swedish National Electrical Safety Board. Most of our knowledge of the health consequences of these arise from clinical case series. Severe electrical injuries have direct thermal effects and may result in ventricular fibrillation, skin burns, as well as muscular and nerve affection. Long-term consequences include pain, vascular symptoms, cognitive and neurological symptoms and signs...
December 1, 2016: Läkartidningen
https://www.readbyqxmd.com/read/27922699/adhesion-and-invasion-of-streptococcus-pneumoniae-to-primary-and-secondary-respiratory-epithelial-cells
#4
Sara Novick, Marilous Shagan, Karin Blau, Sarit Lifshitz, Noga Givon-Lavi, Nili Grossman, Lipa Bodner, Ron Dagan, Yaffa Mizrachi Nebenzahl
The interaction between Streptococcus pneumoniae (S. pneumoniae) and the mucosal epithelial cells of its host is a prerequisite for pneumococcal disease development, yet the specificity of this interaction between different respiratory cells is not fully understood. In the present study, three areas were examined: i) The capability of the encapsulated S. pneumoniae serotype 3 strain (WU2) to adhere to and invade primary nasal‑derived epithelial cells in comparison to primary oral‑derived epithelial cells, A549 adenocarcinoma cells and BEAS‑2B viral transformed bronchial cells; ii) the capability of the unencapsulated 3...
December 6, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27922550/a-novel-abcc6-haplotype-is-associated-with-azathioprine-drug-response-in-myasthenia-gravis
#5
Lara Colleoni, Barbara Galbardi, Claudia Barzago, Silvia Bonanno, Sara Franzi, Rita Frangiamore, Giorgia Camera, Maria Foti, Donatella Biancolini, Eleonora Canioni, Lorenzo Maggi, Carlo Antozzi, Renato Mantegazza, Pia Bernasconi, Dimos Kapetis
OBJECTIVE: We investigated the association of single nucleotide polymorphisms (SNPs) in drug-metabolizing enzymes and transporters (DMETs) with the response to azathioprine (AZA) in patients affected by myasthenia gravis (MG) to determine possible genotype-phenotype correlations. PATIENTS AND METHODS: Genomic DNA from 180 AZA-treated MG patients was screened through the Affymetrix DMET platform, which characterizes 1931 SNPs in 225 genes. The significant SNPs, identified to be involved in AZA response, were subsequently validated by allelic discrimination and direct sequencing...
December 2, 2016: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/27922193/phagocytosis-of-collagen-fibrils-by-fibroblasts-in-vivo-is-independent-of-the-uparap-endo180-receptor
#6
Sara Sprangers, Niels Behrendt, Lars Engelholm, Yixuan Cao, Vincent Everts
As a crucial step in ECM remodeling, collagen degradation occurs through different processes, including both extracellular and intracellular degradation. The extracellular pathways of collagen degradation require secretion of collagenolytic proteases, whereas intracellular collagen degradation occurs in the lysosomal compartment after uptake, involving either pre-cleaved or intact fibrillar collagen. The endocytic collagen receptor uPARAP/Endo180 plays an important role in internalization of large collagen degradation products, whereas its role in the phagocytosis of fibrillar collagen has been debated...
December 6, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27921220/increased-cell-free-mitochondrial-dna-is-a-marker-of-ongoing-inflammation-and-better-neurocognitive-function-in-virologically-suppressed-hiv-infected-individuals
#7
Josué Pérez-Santiago, Michelli F De Oliveira, Susanna R Var, Tyler R C Day, Steven P Woods, Sara Gianella, Sanjay R Mehta
Cell-free mitochondrial DNA (mtDNA) is a highly immunogenic molecule that is associated with several inflammatory conditions and with neurocognitive impairment during untreated HIV infection. Here, we investigate how cell-free mtDNA in cerebrospinal fluid (CSF) is associated with inflammation, neuronal damage, and neurocognitive functioning in the context of long-term suppressive antiretroviral therapy (ART). We quantified the levels of cell-free mtDNA in the CSF from 41 HIV-infected individuals with completely suppressed HIV RNA levels in blood plasma (<50 copies/mL) by droplet digital PCR...
December 5, 2016: Journal of Neurovirology
https://www.readbyqxmd.com/read/27921091/the-relationship-between-serum-vitamin-d-level-and-premenstrual-syndrome-in-iranian-women
#8
Samira Rajaei, Azadeh Akbari Sene, Sara Norouzi, Yasrin Berangi, Sahereh Arabian, Parvaneh Lak, Ali Dabbagh
BACKGROUND: Premenstrual syndrome (PMS) is among the most unfavorable problems in women in reproductive age; however its pathophysiology is still not fully confirmed. Vitamin D as an immunomodulator could prevent inflammatory state before and during menstruation. OBJECTIVE: The aim was to investigate whether there is any relationship between serum vitamin D levels and PMS. MATERIALS AND METHODS: In total, 82 women participate in this case-control study which was conducted in Shahid Akbar-abadi hospital from November 2013 to March 2015...
October 2016: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/27921012/expression-of-the-gene-for-autotransporter-autb-of-neisseria-meningitidis-affects-biofilm-formation-and-epithelial-transmigration
#9
Jesús Arenas, Fernanda L Paganelli, Patricia Rodríguez-Castaño, Sara Cano-Crespo, Arie van der Ende, Jos P M van Putten, Jan Tommassen
Neisseria meningitidis is a Gram-negative bacterium that resides as a commensal in the upper respiratory tract of humans, but occasionally, it invades the host and causes sepsis and/or meningitis. The bacterium can produce eight autotransporters, seven of which have been studied to some detail. The remaining one, AutB, has not been characterized yet. Here, we show that the autB gene is broadly distributed among pathogenic Neisseria spp. The gene is intact in most meningococcal strains. However, its expression is prone to phase variation due to slipped-strand mispairing at AAGC repeats located within the DNA encoding the signal sequence and is switched off in the vast majority of these strains...
2016: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/27920972/potentially-preventable-hospitalizations-for-acute-and-chronic-conditions-in-alaska-2010-2012
#10
Prabhu P Gounder, Sara M Seeman, Robert C Holman, Alice Rarig, Mary K McEwen, Claudia A Steiner, Michael L Bartholomew, Thomas W Hennessy
OBJECTIVE: The U.S. Agency for Healthcare Research and Quality's Prevention Quality Indicators comprise acute and chronic conditions for which hospitalization can be potentially prevented by high-quality ambulatory care. The Healthy Alaska 2020 initiative (HA2020) targeted reducing potentially preventable hospitalizations (PPH) for acute and chronic conditions among its health indicators. We estimated the PPH rate for adults aged ≥ 18 years in Alaska during 2010-2012. METHODS: We conducted a cross-sectional analysis of state-wide hospital discharge data obtained from the Healthcare Cost and Utilization Project and the Indian Health Service...
December 2016: Preventive Medicine Reports
https://www.readbyqxmd.com/read/27920943/a-pilot-dental-survey-on-maui
#11
Olivia Jenkins, Sara Routley, Tina Pedro-Gomes, Lorrin Pang
Routine dental screening surveys of third graders have proven to be a useful tool to monitor the dental health of a community, especially those of highest risk. In 2010 the PEW Charitable Trust (PEW) conducted state-by-state oral hygiene assessments, giving Hawai'i a poor grade, with routine dental surveys of children one of several criteria not met. The Maui Oral Health Task Force piloted its own survey for the island of Maui to assess the challenges in implementing a dental screening and to gain an understanding as to how obstacles might be addressed...
November 2016: Hawai'i Journal of Medicine & Public Health: a Journal of Asia Pacific Medicine & Public Health
https://www.readbyqxmd.com/read/27920756/salmonella-typhimurium-and-multidirectional-communication-in-the-gut
#12
REVIEW
Elena V Gart, Jan S Suchodolski, Thomas H Welsh, Robert C Alaniz, Ronald D Randel, Sara D Lawhon
The mammalian digestive tract is home to trillions of microbes, including bacteria, archaea, protozoa, fungi, and viruses. In monogastric mammals the stomach and small intestine harbor diverse bacterial populations but are typically less populated than the colon. The gut bacterial community (microbiota hereafter) varies widely among different host species and individuals within a species. It is influenced by season of the year, age of the host, stress and disease. Ideally, the host and microbiota benefit each other...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27920701/choroidal-metastasis-as-an-unusual-initial-presentation-of-transitional-cell-carcinoma-of-the-kidney
#13
Jamal Khader, Sara Mheid, Fawzi AbuHijla, Nadi AlKarmi, Yacoub Yousef, Yazan Othman
Metastases of transitional cell carcinoma (TCC) of the renal pelvis to the eye is a very rare event, as only one previous case has been described in the literature. We present a patient with choroidal metastasis secondary to TCC of the renal pelvis, with a review of the relevant literature. A 61-year-old male presented with sudden-onset loss of vision of the left eye. Upon evaluation and assessment, the patient was found to have unilateral choroidal metastasis secondary to TCC of the renal pelvis. He is currently on palliative chemotherapy with carboplatin and gemcitabine...
September 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/27920631/invasive-lobular-carcinoma-of-the-breast-appearance-on-digital-breast-tomosynthesis
#14
Ahuva Grubstein, Yael Rapson, Sara Morgenstern, Itai Gadiel, Amit Haboosheh, Rinat Yerushalmi, Maya Cohen
BACKGROUND: The aim of this study was to characterize the signs of invasive lobular carcinoma of the breast on digital breast tomosynthesis (DBT) imaging. PATIENTS AND METHODS: The study group included 23 women with pathologically proven invasive lobular carcinoma of the breast for whom both digital mammography (DM) and DBT images were available. The images were read jointly by 2 experienced breast radiologists. Findings were recorded according to the descriptors in the Breast Imaging and Reporting Data System lexicon and correlated with the detailed pathology results...
October 2016: Breast Care
https://www.readbyqxmd.com/read/27920623/factors-influencing-decision-making-for-or-against-adjuvant-and-neoadjuvant-chemotherapy-in-postmenopausal-hormone-receptor-positive-breast-cancer-patients-in-the-evaluate-tm-study
#15
Paul Gaß, Peter A Fasching, Tanja Fehm, Johann de Waal, Mahdi Rezai, Bernd Baier, Gerold Baake, Hans-Christian Kolberg, Martin Guggenberger, Mathias Warm, Nadia Harbeck, Rachel Wuerstlein, Jörg-Uwe Deuker, Peter Dall, Barbara Richter, Grischa Wachsmann, Cosima Brucker, Jan W Siebers, Nikos Fersis, Thomas Kuhn, Christopher Wolf, Hans-Walter Vollert, Georg-Peter Breitbach, Wolfgang Janni, Robert Landthaler, Andreas Kohls, Daniela Rezek, Thomas Noesselt, Gunnar Fischer, Stephan Henschen, Thomas Praetz, Volker Heyl, Thorsten Kühn, Thomas Krauss, Christoph Thomssen, Andre Hohn, Hans Tesch, Christoph Mundhenke, Alexander Hein, Claudia Rauh, Christian M Bayer, Adib Jacob, Katja Schmidt, Erik Belleville, Peyman Hadji, Sara Y Brucker, Matthias W Beckmann, Diethelm Wallwiener, Sherko Kümmel, Christian R Löhberg
BACKGROUND: Decision-making for or against neoadjuvant or adjuvant chemotherapy in postmenopausal patients with hormone receptor-positive breast cancer does not follow any clear guidelines, and some patients may unnecessarily undergo chemotherapy and be exposed to the associated toxicity. The aim of this study was to identify the patient population for whom this issue may bear relevance. METHODS: Patients being treated with letrozole in the prospective multicenter noninterventional EvAluate-TM study were recruited...
October 2016: Breast Care
https://www.readbyqxmd.com/read/27920578/recording-of-hospitalizations-for-acute-exacerbations-of-copd-in-uk-electronic-health-care-records
#16
Kieran J Rothnie, Hana Müllerová, Sara L Thomas, Joht S Chandan, Liam Smeeth, John R Hurst, Kourtney Davis, Jennifer K Quint
BACKGROUND: Accurate identification of hospitalizations for acute exacerbations of chronic obstructive pulmonary disease (AECOPD) within electronic health care records is important for research, public health, and to inform health care utilization and service provision. We aimed to develop a strategy to identify hospitalizations for AECOPD in secondary care data and to investigate the validity of strategies to identify hospitalizations for AECOPD in primary care data. METHODS: We identified patients with chronic obstructive pulmonary disease (COPD) in the Clinical Practice Research Datalink (CPRD) with linked Hospital Episodes Statistics (HES) data...
2016: Clinical Epidemiology
https://www.readbyqxmd.com/read/27920268/clinical-value-of-perfusion-abnormalities-of-brain-on-technetium-99m-hmpao-single-photon-emission-computed-tomography-in-children-with-sydenham-chorea
#17
Sara Maria Delle Acque Giorgio, Maria Grazia Caprio, Flavia Galante, Giustina Russo, Alfonso Romano, Emilia Vergara, Maria Alessio, Alberto Cuocolo
We evaluated whether perfusion brain abnormalities by single-photon emission computed tomography (SPECT) imaging improves diagnostic and prognostic assessment in Sydenham chorea. Twenty-three children with acute autoimmune chorea underwent technetium-99m hexamethylpropyleneamine oxime brain SPECT imaging. In 16 children, SPECT was repeated during the follow-up. A pattern of basal ganglia hyperperfusion was observed in 20 (87%) patients. In 4 of 10 patients with generalized chorea, perfusion was comparable in right and left striatum and right and left thalamus...
December 5, 2016: Journal of Child Neurology
https://www.readbyqxmd.com/read/27920188/the-nuclear-medicine-advanced-associate-a-strategic-decision-and-future-direction
#18
Sara G Johnson
No abstract text is available yet for this article.
December 2016: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/27919980/intraperitoneal-chemotherapy-in-patients-pretreated-for-ovarian-cancer-matched-with-patients-treated-with-parenteral-chemotherapy
#19
Maria Ornella Nicoletto, Alessandra Casarin, Alessandra Baldoni, Eliana Rulli, Giulia Tasca, Zora Baretta, Grazia Artioli, Giuseppe Lombardi, Alessandro Cappetta, Irene Floriani, Giovanni Randon, Sara Valpione, Piero Litta, Pierfranco Conte, Simone Mocellin, Camillo Aliberti
BACKGROUND: Our aim was to analyze the impact of intraperitoneal chemotherapy (IPC), administered with direct peritoneal puncture, on the survival of patients with pretreated ovarian cancer in a real-life setting. PATIENTS AND METHODS: This was a retrospective study comparing patients with advanced ovarian cancer treated with IPC (N=33) and patients treated with standard intravenous (i.v.) chemotherapy matching cases for known prognostic factors (age, platinum sensitivity, histological subgroup and grade)...
December 2016: Anticancer Research
https://www.readbyqxmd.com/read/27919970/11c-acetate-pet-ct-compared-to-99mtc-hdp-bone-scintigraphy-in-primary-staging-of-high-risk-prostate-cancer
#20
Sara Strandberg, Camilla Thellenberg Karlsson, Mattias Ogren, Jan Axelsson, Katrine Riklund
AIM: The aim of this study was to evaluate the detection rate of bone metastases and the added value of (11)C-acetate (ACE) positron-emission tomography/computed tomography (PET/CT) compared to bone scintigraphy (BS) in high-risk prostate cancer (PC). MATERIALS AND METHODS: A total of 66 untreated patients with high-risk PC with ACE-PET/CT and planar BS findings within 3 months of each other were retrospectively enrolled. Findings were compared and verified with follow-up data after an average of 26 months...
December 2016: Anticancer Research
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