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https://www.readbyqxmd.com/read/27907062/sepsis-prevalence-and-outcome-on-the-general-wards-and-emergency-departments-in-wales-results-of-a-multi-centre-observational-point-prevalence-study
#1
Tamas Szakmany, Robert M Lundin, Ben Sharif, Gemma Ellis, Paul Morgan, Maja Kopczynska, Amrit Dhadda, Charlotte Mann, Danielle Donoghue, Sarah Rollason, Emma Brownlow, Francesca Hill, Grace Carr, Hannah Turley, James Hassall, James Lloyd, Llywela Davies, Michael Atkinson, Molly Jones, Nerys Jones, Rhodri Martin, Yousef Ibrahim, Judith E Hall
Data on sepsis prevalence on the general wards is lacking on the UK and in the developed world. We conducted a multicentre, prospective, observational study of the prevalence of patients with sepsis or severe sepsis on the general wards and Emergency Departments (ED) in Wales. During the 24-hour study period all patients with NEWS≥3 were screened for presence of 2 or more SIRS criteria. To be eligible for inclusion, patients had to have a high clinical suspicion of an infection, together with a systemic inflammatory response (sepsis) and evidence of acute organ dysfunction and/or shock (severe sepsis)...
2016: PloS One
https://www.readbyqxmd.com/read/27900952/a-novel-deep-learning-approach-for-classification-of-eeg-motor-imagery-signals
#2
Yousef Rezaei Tabar, Ugur Halici
OBJECTIVE: Signal classification is an important issue in brain computer interface (BCI) systems. Deep learning approaches have been used successfully in many recent studies to learn features and classify different types of data. However, the number of studies that employ these approaches on BCI applications is very limited. In this study we aim to use deep learning methods to improve classification performance of EEG motor imagery signals. APPROACH: In this study we investigate convolutional neural networks (CNN) and stacked autoencoders (SAE) to classify EEG Motor Imagery signals...
November 30, 2016: Journal of Neural Engineering
https://www.readbyqxmd.com/read/27894112/association-of-mbl2-gene-polymorphism-with-dental-caries-in-saudi-children
#3
Yousef M Alyousef, J Francis Borgio, Sayed AbdulAzeez, Naif Al-Masoud, Ali A Al-Ali, Emad Al-Shwaimi, Amein K Al-Ali
The high prevalence of dental caries in children worldwide is a major oral health problem which requires early intervention. Dental caries is mainly caused by the action of acids produced by bacteria in addition to many other factors. Recent genetic studies have reported that a number of genes are associated with the susceptibility to dental caries. The majority of these genes are associated with inflammation, increased susceptibility to infection, and dentine matrix formation. Using the TaqMan assay and direct DNA sequencing, the prevalence of 6 single-nucleotide polymorphisms (SNPs) in MMP9, MBL2, MMP2, and TIMP2 genes was determined in 102 children with caries and in 100 age-matched caries-free controls...
November 29, 2016: Caries Research
https://www.readbyqxmd.com/read/27893918/breast-milk-collection-and-storage-in-the-neonatal-intensive-care-unit-nurses-knowledge-practice-and-perceived-barriers
#4
Huda Falah Gharaibeh, Nihaya Al-Sheyab, Shefa Yousef Malkawi
BACKGROUND: Temporary storage of human milk under appropriate conditions encourages prolonged breast-feeding. PURPOSE: This study aimed to assess neonatal nurses' knowledge and practice, as well as barriers, related to breast milk collection and storage and to investigate the association between nurses' knowledge and practice and other variables. METHOD: A cross-sectional design was used. Consecutive samplings of 75 nurses were recruited. The questions were based on a literature review of guidelines for collecting and storing breast milk from various sources, such as the Centers for Disease Control and Prevention and the Academy of Breastfeeding Medicine...
December 1, 2016: Journal of Continuing Education in Nursing
https://www.readbyqxmd.com/read/27893491/role-of-low-molecular-weight-heparins-in-prevention-of-thromboembolic-complication-after-transarterial-chemoembolization-in-hepatocellular-carcinoma
#5
Osama Negm, Sabry Abou Saif, Mohamed El Gharib, Mohamed Yousef, Sherief Abd-Elsalam
BACKGROUND AND AIM: Portal vein thrombosis (PVT) is a common complication after transarterial chemoembolization (TACE) in hepatocellular carcinoma (HCC). This is the first clinical study to evaluate the role of low-molecular-weight heparins (LMWHs) with TACE in HCC for the prevention of thromboembolism complications (PVT). PATIENTS AND METHODS: This study was carried out on 40 patients with HCC requiring TACE who presented to the Tropical Medicine Department, Tanta University and Interventional Radiology Department of Ain-Shams University Hospitals starting from April 2015...
November 23, 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27884380/association-of-endothelial-dysfunction-and-cytotoxin-associated-gene-a-positive-helicobacter-pylori-in-patients-with-cardiac-syndrome-x
#6
COMMENT
Yousef Rasmi, Hadi Rouhrazi, Ebrahim Khayati-Shal, Alireza Shirpoor, Ehsan Saboory
BACKGROUND: Existence of coronary endothelial dysfunction has been demonstrated in patients with cardiac syndrome X (CSX). In addition, Helicobacter pylorus (H. pylori) has been associated with CSX. We aimed to assess the possible association of endothelial dysfunction and cytotoxin-associated gene A-positive H. pylori (CagA+) infection in CSX patients. METHODS: Fifty-six patients with CSX (23 male/33 female; age: 51.25 ± 8.86 years) who were anti-H. pylori IgG-positive [H...
October 2016: Biomedical Journal
https://www.readbyqxmd.com/read/27882779/ipilimumab-from-preclinical-development-to-future-clinical-perspectives-in-melanoma
#7
Paul Letendre, Varun Monga, Mohammed Milhem, Yousef Zakharia
The arsenal for the treatment of metastatic melanoma is limited. A new approach to therapy using checkpoint blockade has improved overall survival in this patient population. Ipilimumab a CTLA-4 monoclonal antibody is a first in class drug that has pioneered this revolution. In this review, the authors provide an account of the different stages that led to the development of ipilimumab, its approval in the clinical setting for the treatment of advanced melanoma and ongoing investigations of combinatorial immune therapy...
November 24, 2016: Future Oncology
https://www.readbyqxmd.com/read/27882203/effectiveness-of-emotion-regulation-training-on-the-reduction-of-craving-in-drug-abusers
#8
Hamed Choopan, Seyed Mohammad Kalantarkousheh, Yousef Aazami, Younes Doostian, Ali Farhoudian, Omid Massah
BACKGROUND: Emotion regulation appears to provide individuals with a doubled ability to avoid drug relapse and assists with the control of temptation to reuse, which is a type of tendency-avoidance conflict. The present study aims to investigate the effect of Gross model-based emotion regulation training on the reduction of craving beliefs in drug-addicted people. METHODS: The present study was a quasi-experimental design. This was a pre- and post-test design that consisted of control and experimental groups...
April 2016: Addiction & Health
https://www.readbyqxmd.com/read/27880086/comparing-the-effects-of-calendula-officinalis-and-clotrimazole-on-vaginal-candidiasis-a-randomized-controlled-trial
#9
Elnaz Saffari, Sakineh Mohammad-Alizadeh-Charandabi, Mohammad Adibpour, Mojgan Mirghafourvand, Yousef Javadzadeh
This triple-blind trial examined the effects of Calendula officinalis vaginal cream on the treatment of vaginal Candidiasis (primary outcome) and sexual function (secondary outcome). Married women aged 18-45 years with vaginal Candidiasis (n = 150) were recruited from April to October 2014 and randomized into Calendula and clotrimazole groups, using 5-gram vaginal cream every night for 7 nights. Clinical and laboratory assessments were conducted at 10-15 and 30-35 days after intervention and the female sexual function index was assessed at 30-35 days...
November 23, 2016: Women & Health
https://www.readbyqxmd.com/read/27871037/design-synthesis-and-sar-analysis-of-potent-bace1-inhibitors-possible-lead-drug-candidates-for-alzheimer-s-disease
#10
Hamadeh Tarazi, Raed Abu Odeh, Raed Al-Qawasmeh, Imad Abu Yousef, Wolfgang Voelter, Taleb H Al-Tel
We have identified potent isophthalic acid derivatives armed with imidazol and indolyl groups as potent β-secretase inhibitors. The most effective analogs demonstrated low nano-molar potency for the BACE1 (β-secretase cleaving enzyme) as measured by FRET (Fluorescence Resonance Energy Transfer) and cell-based (ELISA) assays. Our design strategy followed a traditional SAR approach and was supported by molecular modeling studies based on previously reported hydroxyethylene transition state inhibitor derived from isophthalic acid I...
November 12, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27870995/agronomic-assessment-of-pyrolysed-food-waste-digestate-for-sandy-soil-management
#11
Suraj Adebayo Opatokun, Lina F Yousef, Vladimir Strezov
The digestate (DFW) of an industrial food waste treatment plant was pyrolysed for production of biochar for its direct application as bio-fertilizer or soil enhancer. Nutrient dynamics and agronomic viability of the pyrolysed food waste digestate (PyD) produced at different temperatures were evaluated using germination index (GI), water retention/availability and mineral sorption as indicators when applied on arid soil. The pyrolysis was found to enrich P, K and other micronutrients in the biochar at an average enrichment factor of 0...
November 18, 2016: Journal of Environmental Management
https://www.readbyqxmd.com/read/27869665/anticancer-effects-of-rosemary-rosmarinus-officinalis-l-extract-and-rosemary-extract-polyphenols
#12
REVIEW
Jessy Moore, Michael Yousef, Evangelia Tsiani
Cancer cells display enhanced growth rates and a resistance to apoptosis. The ability of cancer cells to evade homeostasis and proliferate uncontrollably while avoiding programmed cell death/apoptosis is acquired through mutations to key signaling molecules, which regulate pathways involved in cell proliferation and survival. Compounds of plant origin, including food components, have attracted scientific attention for use as agents for cancer prevention and treatment. The exploration into natural products offers great opportunity to evaluate new anticancer agents as well as understand novel and potentially relevant mechanisms of action...
November 17, 2016: Nutrients
https://www.readbyqxmd.com/read/27867394/association-of-tissue-transglutaminase-antibody-titer-with-duodenal-histological-changes-in-children-with-celiac-disease
#13
Hasan Hawamdeh, Basim Al-Zoubi, Yasameen Al Sharqi, Ayman Qasrawi, Yousef Abdelaziz, Maha Barbar
Celiac disease is usually diagnosed by demonstrating gluten enteropathy in small bowel biopsy. Celiac specific antibodies are used as an initial screening test. The goal of this study is to test the relationship of the anti-tTG titer and severity of histological changes in Jordanian children with celiac disease. Method. The medical records of 81 children who had elevated anti-tTG titer and had duodenal biopsies available were retrospectively reviewed. Result. Assessing the association of anti-tTG titer with duodenal histopathological changes, 94% of those with high anti-tTG titer (≥180 U/mL) had histological evidence of celiac disease...
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/27865314/surgical-treatment-options-for-the-diabetic-charcot-midfoot-deformity
#14
REVIEW
Yousef Alrashidi, Thomas Hügle, Martin Wiewiorski, Mario Herrera-Perez, Victor Valderrabano
Management of diabetic Charcot midfoot deformity is one of the most demanding aspects of foot and ankle surgery. Its treatment should aim at reducing the rate of complications, including foot and ankle amputations or limb loss. Attempting reconstruction at Eichenholtz stages I and II carries the risk of infection and loss of fixation. It is advisable to limit surgical reconstruction to Eichenholtz stage III in the absence of any evidence of infection or vascular insufficiency. Achilles lengthening or gastrocnemius-soleus release is an essential initial step in surgery...
January 2017: Clinics in Podiatric Medicine and Surgery
https://www.readbyqxmd.com/read/27862211/the-effects-of-intra-hippocampal-l-thyroxine-infusion-on-long-term-potentiation-and-long-term-depression-a-possible-role-for-the-%C3%AE-v%C3%AE-3-integrin-receptor
#15
Soner Bitiktaş, Burak Tan, Şehrazat Kavraal, Marwa Yousef, Yeliz Bayar, Nurcan Dursun, Cem Süer
Although the effects of long-term experimental dysthyroidism on long-term potentiation (LTP) and long-term depression (LTD) have been documented, the relationship between LTP/LTD and acute administration of L-thyroxine (T4) has not been described. Here, we investigated the effects of intra-hippocampal administration of T4 on synaptic plasticity in the dentate gyrus of the hippocampal formation. After a 15-minute baseline recording, LTP and LTD were induced by application of high- and low-frequency stimulation protocols, respectively...
November 10, 2016: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27858819/coma-prognostication-looks-that-count
#16
Robert D Stevens, Yousef Hannawi
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27856787/correction-apoe-deficiency-promotes-colon-inflammation-and-enhances-the-inflammatory-potential-of-oxidized-ldl-and-tnf-%C3%AE-in-primary-colon-epithelial-cells
#17
Ali H El-Bahrawy, Abdelmetalab Tarhuni, Hogyoung Kim, Venkat Subramaniam, Ilyes Benslimane, Zakaria Y Abd Elmageed, Samuel C Okpechi, Mohamed A Ghonim, Ramadan A M Hemeida, Amira M Abo-Yousef, Gamal A El-Sherbiny, Ihab T Abdel-Raheem, Jong Kim, Amarjit S Naura, A Hamid Boulares
No abstract text is available yet for this article.
December 2016: Bioscience Reports
https://www.readbyqxmd.com/read/27852428/a-pilot-study-to-assess-relationship-between-total-ige-and-95-predictive-decision-points-of-food-specific-ige-concentration
#18
E Yousef, A S Haque
BACKGROUND: False positive test results in children who are tested for food allergies may lead to inappropriate dietary restrictions. OBJECTIVE: The aim of this study was to report our experience with a 3 year-old boy, who presented with "multiple food allergies" and, however, passed the food challenges, and to review our experience regarding management of children with high specific food IgEs with high total IgE. METHODS: Medical records of 16 children with food challenges were reviewed...
November 2016: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27851526/1891-neurally-adjusted-ventilatory-assist-weaning-of-neonates-with-congenital-diaphragmatic-hernia
#19
Adam Szadkowski, Michael Wilhelm, Jamie Limjoco, David Mcculley, Chuck Leys, Yousef AlAli, Awni Al-Subu
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27851448/1813-from-intubated-and-unresponsive-to-hospice
#20
Mohammad Yousef, Amy Heibel, Sonia Malhotra, Abdul Khan
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
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