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https://www.readbyqxmd.com/read/28090624/current-strategies-for-the-immunotherapy-of-multiple-myeloma
#1
REVIEW
Tim Luetkens, Sara Yousef, Sabarinath Venniyil Radhakrishnan, Djordje Atanackovic
The introduction of cellular immunotherapies using genetically modified T cells has revolutionized the treatment of patients with B-cell lymphomas. However, despite the progress made in this field, similarly effective immunotherapeutic approaches have not yet been identified for patients with solid tumors or other hematologic malignancies such as multiple myeloma. Here we outline the most promising novel cellular immune strategies for patients with multiple myeloma. In addition, we highlight combinatorial approaches that, it is hoped, will further optimize cellular immunotherapies for myeloma and lead to deep and durable responses and, possibly, even cures...
January 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/28088439/antimicrobial-activity-of-photodynamic-therapy-in-combination-with-colistin-against-a-pan-drug-resistant-acinetobacter-baumannii-isolated-from-burn-patient
#2
Ebrahim Boluki, Hossein Kazemian, Hadi Peeridogaheh, Mohammad Yousef Alikhani, Sima Shahabi, Leili Beytollahi, Roghayeh Ghorbanzadeh
Nosocomially-acquired multi-, extensively-, and pandrug resistant (MDR, XDR, and PDR) strains of microorganisms such as Acinetobacter baumannii remain a serious cause of infection and septic mortality in burn patients. Treatment of patients with nosocomial burn wound infections is often complicated by drug-resistant strains of A. baumannii. Today, many researchers are focusing on the investigation of novel non-antibiotic strategies such as photodynamic therapy (PDT). We report a new PDT strategy that suppresses colistin resistance in PDR A...
January 11, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28087154/evaluation-of-serial-high-sensitivity-troponin-t-levels-in-individuals-without-overt-coronary-heart-disease-following-exercise-stress-testing
#3
Yousef M E Saad, Hanan Idris, Ibrahim M Shugman, Krishna K Kadappu, Rohan Rajaratnam, Liza Thomas, Christian Mussap, Dominic Y C Leung, Craig P Juergens, John K French
BACKGROUND: Detectable levels of high sensitivity (cardiac) troponin T (HsTnT), occur in the majority of patients with stable coronary heart disease (CHD), and often in 'healthy' individuals. Extreme physical activity may lead to marked elevations in creatine kinase MB and TnT levels. However, whether HsTnT elevations occur commonly after exercise stress testing (EST), and if so, whether this has clinical significance, needs clarification. METHODS: To determine whether HsTnT levels become elevated after EST (Bruce protocol) to ≥95% of predicted maximum heart rate in presumed healthy subjects without overt CHD, we assayed HsTnT levels for ∼5h post-EST in 105 subjects (median age 37 years)...
December 9, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28081542/galectin-1-has-potential-prognostic-significance-and-is-implicated-in-clear-cell-renal-cell-carcinoma-progression-through-the-hif-mtor-signaling-axis
#4
N M A White, O Masui, D Newsted, A Scorilas, A D Romaschin, G A Bjarnason, K W M Siu, G M Yousef
No abstract text is available yet for this article.
January 12, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28070915/mitral-valve-resistance-determines-hemodynamic-consequences-of-severe-rheumatic-mitral-stenosis-and-immediate-outcomes-of-percutaneous-valvuloplasty
#5
Hamidreza Sanati, Reza Zolfaghari, Niloufar Samiei, Yousef Rezaei, Mitra Chitsazan, Ali Zahedmehr, Farshad Shakerian, Reza Kiani, Ata Firouzi, Reza Rezaei Tabrizi
INTRODUCTION: The mitral valve area (MVA) poorly reflects the hemodynamic status of (MS). In this study, we compared the MVA with mitral valve resistance (MVR) with regard to the determination of hemodynamic consequences of MS and the immediate outcomes of percutaneous balloon mitral valvuloplasty (PBMV). METHODS: In a prospective study, 36 patients with severe rheumatic MS with left ventricular ejection fraction (LVEF) >50% were evaluated. They underwent transthoracic echocardiography (TTE) and catheterization...
January 10, 2017: Echocardiography
https://www.readbyqxmd.com/read/28058083/simulating-the-hydrodynamics-of-self-propelled-colloidal-clusters-using-stokesian-dynamics
#6
Yousef M F El Hasadi, Martin Crapper
Self-propelled clusters are involved in many technological applications such as in material science and biotechnology, and understanding their interaction with the fluid that surrounds them is of a great importance. We present results of swimming velocity and energy dissipation obtained through Stokesian dynamics simulations of self-propelled clusters. The clusters are of diffusion limited aggregates, consisting of force- and torque-free spherical particles. The number of particles per cluster ranges from 100 to 400, and with two fractal dimensions of 2...
November 2016: Biomicrofluidics
https://www.readbyqxmd.com/read/28053964/the-evaluation-of-p53-polymorphism-at-codon-72-and-association-with-breast-cancer-in-iran-a-systematic-review-and-meta-analysis
#7
Abozar Soleimani, Yousef Rahmani, Negin Farshchian, Ali Delpisheh, Kivan Khassi, Afshar Shahmohammadi, Nasrin Amirifard
BACKGROUND: Breast cancer is the most common cancer among women in Iran and the world. Multiple environmental factors and genetic variations such as genetic polymorphisms are of its main causes. p53 gene plays an important role in conserving and sustaining the genome as a tumor suppressing gene. Change and polymorphism at codon 72 of p53 gene are correlated with increased risk of lung, mouth, endometrial, prostate, and colorectal cancers, and could be considered an indicator of susceptibility to breast cancer...
December 2016: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28052035/brca1-iris-overexpression-promotes-and-maintains-the-tumor-initiating-phenotype-implications-for-triple-negative-breast-cancer-early-lesions
#8
Abhilasha Sinha, Bibbin T Paul, Lisa M Sullivan, Hillary Sims, Ahmed El Bastawisy, Hend F Yousef, Abdel-Rahman N Zekri, Abeer A Bahnassy, Wael M ElShamy
Tumor-initiating cells (TICs) are cancer cells endowed with self-renewal, multi-lineage differentiation, increased chemo-resistance, and in breast cancers the CD44+/CD24-/ALDH1+ phenotype. Triple negative breast cancers show lack of BRCA1 expression in addition to enhanced basal, epithelial-to-mesenchymal transition (EMT), and TIC phenotypes. BRCA1-IRIS (hereafter IRIS) is an oncogene produced by the alternative usage of the BRCA1 locus. IRIS is involved in induction of replication, transcription of selected oncogenes, and promoting breast cancer cells aggressiveness...
December 29, 2016: Oncotarget
https://www.readbyqxmd.com/read/28050979/assessment-of-the-pubertal-growth-period-using-the-open-apices-of-the-lower-teeth
#9
Yousef N Issa, Ahmad S Burhan, Fehmieh R Nawaya, Lama G Massouh
AIM: The purpose of this study was to evaluate whether the open apex measurements of the lower teeth can be used for prediction of the pubertal growth spurt. MATERIALS AND METHODS: The study group consisted of 150 males and 142 females ranging in age from 10 to 16 years. A total of 292 panoramic and 292 hand-wrist radiographs were obtained and analyzed. The skeletal maturity was determined according to the skeletal maturity indicators (SMIs) developed by Fishman...
January 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28044205/extracorporeal-shock-wave-therapy-for-the-treatment-of-coccydynia-a-series-of-23-cases
#10
Yousef Marwan, Bashar Dahrab, Ali Esmaeel, Samir Abdulrazik Ibrahim, Jassim Al-Failakawi
BACKGROUND: Coccydynia can lead to significant functional disability and worsening of quality of life if not properly managed. In this study, we aim to assess the outcomes of extracorporeal shock wave therapy in patients with coccydynia. METHODS: A prospective case series study was carried out from January to December 2015. Twenty-three patients, mean age of 38.3 ± 12.1 (range 18-64), were included. The majority were females (13; 56.5%), had pain for at least 6 weeks (17; 73...
January 2, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28042639/the-saudi-clinical-practice-guideline-for-the-prophylaxis-of-venous-thromboembolism-in-long-distance-travelers
#11
Fahad M Al-Hameed, Hasan M Al-Dorzi, Mohamed A Abdelaal, Ali Alaklabi, Ebtisam Bakhsh, Yousef A Alomi, Mohammad Al Baik, Salah Aldahan, Holger Schünemann, Jan Brozek, Wojtek Wiercioch, Andrea J Darzi, Reem Waziry, Elie A Akl
Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), is a preventable disease. Long distant travelers are prone to variable degree to develop VTE. However, the low risk of developing VTE among long-distance travelers and which travelers should receive VTE prophylaxis, and what prophylactic measures should be used led us to develop these guidelines. These clinical practice guidelines are the result of an initiative of the Ministry of Health of the Kingdom of Saudi Arabia involving an expert panel led by the Saudi Association for Venous Thrombo Embolism (a subsidiary of the Saudi Thoracic Society)...
January 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28042366/posterior-reversible-encephalopathy-syndrome-local-experience-from-saudi-arabia
#12
Hussein Algahtani, Abdulhadi Algahtani, Ahmad Aldarmahi, Mohammed Hmoud, Yousef Marzuk, Bader Shirah
OBJECTIVES: Posterior reversible encephalopathy syndrome (PRES) is a clinicoradiological syndrome characterized by headache, altered mental status, seizures, or loss of vision. In this study, we report the largest series of PRES coming from Saudi Arabia and explore the etiology, clinical presentation, and outcome. We also report new imaging findings associated with this condition. METHODS: We performed a retrospective study of all cases of PRES admitted to King Abdulaziz Medical City, Jeddah, Saudi Arabia, between the years 2005 and 2015...
January 2017: Neurohospitalist
https://www.readbyqxmd.com/read/28039410/effects-of-novel-muscarinic-m3-receptor-ligand-c1213-in-pulmonary-arterial-hypertension-models
#13
Mohamed Ahmed, Sonya VanPatten, Satyan Lakshminrusimha, Hardik Patel, Thomas R Coleman, Yousef Al-Abed
Pulmonary hypertension (PH) is a complex disease comprising a pathologic remodeling and thickening of the pulmonary vessels causing an after load on the right heart ventricle that can result in ventricular failure. Triggered by oxidative stress, episodes of hypoxia, and other undetermined causes, PH is associated with poor outcomes and a high rate of morbidity. In the neonate, this disease has a similar etiology but is further complicated by the transition to breathing after birth, which requires a reduction in vascular resistance...
December 2016: Physiological Reports
https://www.readbyqxmd.com/read/28036108/cardiac-dysfunction-in-cancer-survivors-unmasked-during-exercise
#14
Maria Kearney, Eve Gallop-Evans, John Cockcroft, Eric J Stöhr, Eveline Lee, Karianne Backx, Mark Haykowsky, Zaheer Yousef, Rob Shave
INTRODUCTION: The cardiac dysfunction associated with anthracycline-based chemotherapy cancer treatment can exist sub-clinically for decades before overt presentation. Stress echocardiography, the measurement of left ventricular (LV) deformation and arterial haemodynamic evaluation have separately been used to identify sub-clinical cardiovascular (CV) dysfunction in several patient groups including those with hypertension and diabetes. The purpose of the present cross-sectional study was to determine whether the combination of these techniques could be used to improve the characterisation of sub-clinical CV dysfunction in long-term cancer survivors previously treated with anthracyclines...
December 30, 2016: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28027499/imbalance-between-the-anti-and-pro-inflammatory-milieu-in-blood-leukocytes-of-autistic-children
#15
Sheikh F Ahmad, Ahmed Nadeem, Mushtaq A Ansari, Saleh A Bakheet, Sabry M Attia, Khairy M A Zoheir, Laila Yousef Al-Ayadhi, Mohammad Z Alzahrani, Abdulaziz M S Alsaad, Moureq R Alotaibi, Adel R A Abd-Allah
Accumulating evidence suggests an association between immune dysfunction and autism disorders in a significant subset of children. In addition, an imbalance between pro- and anti-inflammatory pathways has been proposed to play an important role in the pathogenesis of several neurodevelopmental disorders including autism; however, the role of anti-inflammatory molecules IL-27 and CTLA-4 and pro-inflammatory cytokines IL-21 and IL-22 has not previously been explored in autistic children. In the current study, we investigated the expression of IL-21, IL-22, IL-27, and CD152 (CTLA-4) following an in-vitro immunological challenge of peripheral blood mononuclear cells (PBMCs) from children with autism (AU) or typically-developing children (TD) with phorbol-12-myristate 13-acetate (PMA) and ionomycin...
December 24, 2016: Molecular Immunology
https://www.readbyqxmd.com/read/28024914/topical-and-cutaneous-delivery-using-nanosystems
#16
REVIEW
M S Roberts, Y Mohammed, M N Pastore, S Namjoshi, S Yousef, A Alinaghi, I N Haridass, E Abd, V R Leite-Silva, Hae Benson, J E Grice
The goal of topical and cutaneous delivery is to deliver therapeutic and other substances to a desired target site in the skin at appropriate doses to achieve a safe and efficacious outcome. Normally, however, when the stratum corneum is intact and the skin barrier is uncompromised, this is limited to molecules that are relatively lipophilic, small and uncharged, thereby excluding many potentially useful therapeutic peptides, proteins, vaccines, gene fragments or drug-carrying particles. In this review we will describe how nanosystems are being increasingly exploited for topical and cutaneous delivery, particularly for these previously difficult substances...
December 23, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28024522/brevibacillin-a-cationic-lipopeptide-that-binds-to-lipoteichoic-acid-and-subsequently-disrupts-cytoplasmic-membrane-of-staphylococcus-aureus
#17
Xu Yang, En Huang, Ahmed E Yousef
Brevibacillin is a newly-discovered antimicrobial lipopeptide produced by Brevibacillus laterosporus OSY-I1. It is active against Gram-positive bacteria, including antibiotic resistant strains. This research was initiated to investigate the mechanism of action of brevibacillin against an indicator strain, Staphylococcus aureus ATCC 6538. Results of the study proved that brevibacillin binds to lipoteichoic acid (LTA) on cell wall before interacting with cell membrane. Additionally, brevibacillin disrupts S. aureus cytoplasmic membrane by increasing its permeability, depolarization and potassium leakage...
January 2017: Microbiological Research
https://www.readbyqxmd.com/read/28018286/intra-arterial-infusion-of-autologous-bone-marrow-mononuclear-stem-cells-in-subacute-ischemic-stroke-patients
#18
Azza Abass Ghali, Mohamed Khalil Yousef, Osama AbdAllah Ragab, Enas Arafa ElZamarany
INTRODUCTION: Based on many preclinical and small clinical trials, stem cells can help stroke patient with the possibility of replacing the cells and supporting the remaining cells. The aim of this study was to evaluate the safety and feasibility of bone marrow mononuclear (BMMN) stem cell transplantation in subacute ischemic stroke patients. MATERIALS AND METHODS: Thirty-nine (n = 39) patients with subacute ischemic cerebral infarct due to large artery occlusion in the middle cerebral artery (MCA) territory were recruited...
2016: Frontiers in Neurology
https://www.readbyqxmd.com/read/28017257/autosomal-recessive-cerebellar-ataxia-type-1-mimicking-multiple-sclerosis-a-report-of-two-siblings-with-a-novel-mutation-in-syne1-gene-in-a-saudi-family
#19
Hussein Algahtani, Yousef Marzouk, Raghad Algahtani, Sali Salman, Bader Shirah
Autosomal Recessive Cerebellar Ataxia type 1 (ARCA1), also known as recessive ataxia of Beauce, is an adult onset pure cerebellar ataxia that typically presents with cerebellar ataxia and/or dysarthria. A mutation in the synaptic nuclear envelope protein 1 (SYNE1) gene that is located on chromosome 6p25 results in premature termination of the protein. It was first reported in 2007 as the first identified gene responsible for a recessively inherited pure cerebellar ataxia. In this article, we are presenting two brothers with ARCA1 who were misdiagnosed and treated as multiple sclerosis for more than a decade...
January 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28006039/longitudinal-examination-of-frequency-of-and-risk-factors-for-severe-dry-eye-symptoms-in-us-veterans
#20
Erin S Ong, Yousef A Alghamdi, Roy C Levitt, Allison L McClellan, Gail Lewis, Constantine D Sarantopoulos, Elizabeth R Felix, Anat Galor
Importance: Dry eye syndrome is a common condition that affects millions of individuals. Many cross-sectional studies have evaluated risk factors for dry eye severity, but few have assessed risk factors or symptom progression over time. Objectives: To assess symptom progression in dry eye syndrome and determine risk factors associated with severe symptoms at 1 year. Design, Setting, and Participants: A longitudinal study was conducted from October 1, 2013, to April 30, 2015, among patients at the Miami Veterans Affairs Hospital with a wide variety of dry eye symptoms and signs (ranging from none to severe)...
December 22, 2016: JAMA Ophthalmology
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