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https://www.readbyqxmd.com/read/29343635/combining-radiation-with-hyperthermia-a-multiscale-model-informed-by-in-vitro-experiments
#1
S Brüningk, G Powathil, P Ziegenhein, J Ijaz, I Rivens, S Nill, M Chaplain, U Oelfke, G Ter Haar
Combined radiotherapy and hyperthermia offer great potential for the successful treatment of radio-resistant tumours through thermo-radiosensitization. Tumour response heterogeneity, due to intrinsic, or micro-environmentally induced factors, may greatly influence treatment outcome, but is difficult to account for using traditional treatment planning approaches. Systems oncology simulation, using mathematical models designed to predict tumour growth and treatment response, provides a powerful tool for analysis and optimization of combined treatments...
January 2018: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/29335162/the-effectiveness-of-virtual-simulation-in-improving-student-nurses-knowledge-and-performance-during-patient-deterioration-a-pre-and-post-test-design
#2
Alexis Borg Sapiano, Roberta Sammut, Josef Trapani
BACKGROUND: Preparing nursing students to perform competently in complex emergency situations, such as during rapid patient deterioration, is challenging. Students' active engagement in such scenarios cannot be ensured, due to the unexpected nature of such infrequent events. Many students may consequently not experience and integrate the management of patient deterioration into their knowledge and practical competency by the end of their studies, making them unprepared to manage such situations as practicing nurses...
December 29, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/29324835/subject-specific-pulse-wave-propagation-modeling-towards-enhancement-of-cardiovascular-assessment-methods
#3
Jan Poleszczuk, Malgorzata Debowska, Wojciech Dabrowski, Alicja Wojcik-Zaluska, Wojciech Zaluska, Jacek Waniewski
Cardiovascular diseases are the leading cause of death worldwide. Pulse wave analysis (PWA) technique, which reconstructs and analyses aortic pressure waveform based on non-invasive peripheral pressure recording, became an important bioassay for cardiovascular assessment in a general population. The aim of our study was to establish a pulse wave propagation modeling framework capable of matching clinical PWA data from healthy individuals on a per-subject basis. Radial pressure profiles from 20 healthy individuals (10 males, 10 females), with mean age of 42 ± 10 years, were recorded using applanation tonometry (SphygmoCor, AtCor Medical, Australia) and used to estimate subject-specific parameters of mathematical model of blood flow in the system of fifty-five arteries...
2018: PloS One
https://www.readbyqxmd.com/read/29323043/neural-computational-modeling-reveals-a-major-role-of-corticospinal-gating-of-central-oscillations-in-the-generation-of-essential-tremor
#4
Hong-En Qu, Chuanxin M Niu, Si Li, Man-Zhao Hao, Zi-Xiang Hu, Qing Xie, Ning Lan
Essential tremor, also referred to as familial tremor, is an autosomal dominant genetic disease and the most common movement disorder. It typically involves a postural and motor tremor of the hands, head or other part of the body. Essential tremor is driven by a central oscillation signal in the brain. However, the corticospinal mechanisms involved in the generation of essential tremor are unclear. Therefore, in this study, we used a neural computational model that includes both monosynaptic and multisynaptic corticospinal pathways interacting with a propriospinal neuronal network...
December 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/29319324/on-the-complex-and-reversible-pathways-of-cdse-quantum-dots-driven-by-pyroelectric-dep
#5
Giuseppe Nasti, Sara Coppola, Federico Olivieri, Veronica Vespini, Vito Pagliarulo, Pietro Ferraro
Electrophoresis (EP) and dielectrophoresis (DEP) are two well established methodologies to manipulate nanoparticles (NPs). Recently, a DEP by virtual electrodes platform was demonstrated on ferroelectric substrates where the driving force is due to the strong electric field generated by pyroelectric effect thus opening new scenarios for manipulating the matter. Such innovative approach named pyroelectric-DEP has several advantages over the traditional EP and DEP. However, a detailed study on this novel approach is required for understanding the complex pathways traced by nanoparticles (NP) under the action of the pyroelectric driven forces and thus for explaining the final patterns...
January 10, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29315715/a-mathematical-model-for-pathogen-cross-contamination-dynamics-during-the-postharvest-processing-of-leafy-greens
#6
Amir Mokhtari, David Oryang, Yuhuan Chen, Regis Pouillot, Jane Van Doren
We developed a probabilistic mathematical model for the postharvest processing of leafy greens focusing on Escherichia coli O157:H7 contamination of fresh-cut romaine lettuce as the case study. Our model can (i) support the investigation of cross-contamination scenarios, and (ii) evaluate and compare different risk mitigation options. We used an agent-based modeling framework to predict the pathogen prevalence and levels in bags of fresh-cut lettuce and quantify spread of E. coli O157:H7 from contaminated lettuce to surface areas of processing equipment...
January 8, 2018: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/29308598/a-simulator-based-nuclear-reactor-emergency-response-training-exercise
#7
Edward Waller, George Bereznai, John Shaw, Joseph Chaput, Jean-Francois Lafortune
Training offsite emergency response personnel basic awareness of onsite control room operations during nuclear power plant emergency conditions was the primary objective of a week-long workshop conducted on a CANDU® virtual nuclear reactor simulator available at the University of Ontario Institute of Technology, Oshawa, Canada. The workshop was designed to examine both normal and abnormal reactor operating conditions, and to observe the conditions in the control room that may have impact on the subsequent offsite emergency response...
November 2017: Journal of Emergency Management: JEM
https://www.readbyqxmd.com/read/29300857/modelling-interaction-dynamics-between-two-foliar-pathogens-in-wheat-a-multi-scale-approach
#8
Guillaume Garin, Christophe Pradal, Christian Fournier, David Claessen, Vianney Houlès, Corinne Robert
Background and Aims: Disease models can improve our understanding of dynamic interactions in pathosystems and thus support the design of innovative and sustainable strategies of crop protections. However, most epidemiological models focus on a single type of pathogen, ignoring the interactions between different parasites competing on the same host and how they are impacted by properties of the canopy. This study presents a new model of a disease complex coupling two wheat fungal diseases, caused by Zymoseptoria tritici (septoria) and Puccinia triticina (brown rust), respectively, combined with a functional-structural plant model of wheat...
December 29, 2017: Annals of Botany
https://www.readbyqxmd.com/read/29298957/optimizing-targeted-vaccination-across-cyber-physical-networks-an-empirically-based-mathematical-simulation-study
#9
Enys Mones, Arkadiusz Stopczynski, Alex 'Sandy' Pentland, Nathaniel Hupert, Sune Lehmann
Targeted vaccination, whether to minimize the forward transmission of infectious diseases or their clinical impact, is one of the 'holy grails' of modern infectious disease outbreak response, yet it is difficult to achieve in practice due to the challenge of identifying optimal targets in real time. If interruption of disease transmission is the goal, targeting requires knowledge of underlying person-to-person contact networks. Digital communication networks may reflect not only virtual but also physical interactions that could result in disease transmission, but the precise overlap between these cyber and physical networks has never been empirically explored in real-life settings...
January 2018: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/29290745/virtual-pediatric-patient-activities-with-randomized-scenarios-as-an-instructional-tool-for-pharmacy-students
#10
Jeremy S Stultz, Michael Forder, Amy L Pakyz
OBJECTIVES: To assess student pharmacist best activity scores and related exam question performance based on the number of pediatric virtual patient activity (VPA) attempts. METHODS: A 40-point asthma VPA was implemented and included three possible randomized scenarios. A 60-point meningitis VPA was implemented and included three possible randomized scenarios followed by an additional three possible randomized scenarios only if the first scenario was correctly completed...
November 2017: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/29287111/the-impact-of-pre-existing-anxiety-on-affective-and-cognitive-processing-of-a-virtual-reality-analogue-trauma
#11
Tina Schweizer, Julian Schmitz, Laura Plempe, Dali Sun, Christian Becker-Asano, Rainer Leonhart, Brunna Tuschen-Caffier
Dysfunctional processing of traumatic events may be in particular related to high trait anxiety as a pre-traumatic risk factor for the development of post-traumatic stress disorder (PTSD). However, as this has rarely been investigated in prospective, experimental studies, we aimed to analyse the association between high trait anxiety and affective as well as cognitive processing of stress using a new prospective Virtual Reality analogue trauma paradigm to overcome limitations of retrospective or current analogue designs...
2017: PloS One
https://www.readbyqxmd.com/read/29246640/computational-fluid-dynamic-comparison-between-patch-based-and-primary-closure-techniques-after-carotid-endarterectomy
#12
Maurizio Domanin, Daniele Bissacco, Davide Le Van, Christian Vergara
OBJECTIVE: The aim of the study was to provide, by means of computational fluid dynamics, a comparative analysis after carotid endarterectomy (CEA) between patch graft (PG) and primary closure (PC) techniques performed in real carotid geometries to identify disturbed flow conditions potentially involved in the development of restenosis. METHODS: Eight carotid geometries in seven asymptomatic patients who underwent CEA were analyzed. In six cases (A-F), CEA was performed using PG closure; in two cases (G and H), PC was performed...
December 12, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29242181/a-data-model-for-teleconsultation-in-managing-high-risk-pregnancies-design-and-preliminary-evaluation
#13
Kolsoum Deldar, Fatemeh Tara, Kambiz Bahaadinbeigy, Mohammad Khajedaluee, Mahmood Tara
BACKGROUND: Teleconsultation is a guarantor for virtual supervision of clinical professors on clinical decisions made by medical residents in teaching hospitals. Type, format, volume, and quality of exchanged information have a great influence on the quality of remote clinical decisions or tele-decisions. Thus, it is necessary to develop a reliable and standard model for these clinical relationships. OBJECTIVE: The goal of this study was to design and evaluate a data model for teleconsultation in the management of high-risk pregnancies...
December 14, 2017: JMIR Medical Informatics
https://www.readbyqxmd.com/read/29241068/long-term-projections-of-temperature-related-mortality-risks-for-ischemic-stroke-hemorrhagic-stroke-and-acute-ischemic-heart-disease-under-changing-climate-in-beijing-china
#14
Tiantian Li, Radley M Horton, Daniel A Bader, Fangchao Liu, Qinghua Sun, Patrick L Kinney
BACKGROUND: Changing climates have been causing variations in the number of global ischemic heart disease and stroke incidences, and will continue to affect disease occurrence in the future. OBJECTIVES: To project temperature-related mortality for acute ischemic heart disease, and ischemic and hemorrhagic stroke with concomitant climate warming. METHODS: We estimated the exposure-response relationship between daily cause-specific mortality and daily mean temperature in Beijing...
December 11, 2017: Environment International
https://www.readbyqxmd.com/read/29234302/home-based-virtual-reality-augmented-training-improves-lower-limb-muscle-strength-balance-and-functional-mobility-following-chronic-incomplete-spinal-cord-injury
#15
Michael Villiger, Jasmin Liviero, Lea Awai, Rahel Stoop, Pawel Pyk, Ron Clijsen, Armin Curt, Kynan Eng, Marc Bolliger
Key factors positively influencing rehabilitation and functional recovery after spinal cord injury (SCI) include training variety, intensive movement repetition, and motivating training tasks. Systems supporting these aspects may provide profound gains in rehabilitation, independent of the subject's treatment location. In the present study, we test the hypotheses that virtual reality (VR)-augmented training at home (i.e., unsupervised) is feasible with subjects with an incomplete SCI (iSCI) and that it improves motor functions such as lower limb muscle strength, balance, and functional mobility...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29230375/the-impact-of-choosing-words-carefully-an-online-investigation-into-imaging-reporting-strategies-and-best-practice-care-for-low-back-pain
#16
Emma L Karran, Yasmin Medalian, Susan L Hillier, G Lorimer Moseley
Background: Low back pain clinical practice guidelines consistently recommend against the routine ordering of spinal imaging; however, imaging is frequently requested in primary care, without evidence of benefit. Imaging reports frequently identify degenerative features which are likely to be interpreted as 'abnormal', despite their high prevalence in symptom-free individuals. The aim of this study was to investigate whether post-imaging back-related perceptions are influenced by providing prior information about normal findings, and to compare the effect of receiving imaging results with best practice care (without imaging)...
2017: PeerJ
https://www.readbyqxmd.com/read/29219533/photonic-counterparts-of-cooper-pairs
#17
André Saraiva, Filomeno S de Aguiar Júnior, Reinaldo de Melo E Souza, Arthur Patrocínio Pena, Carlos H Monken, Marcelo F Santos, Belita Koiller, Ado Jorio
The microscopic theory of superconductivity raised the disruptive idea that electrons couple through the elusive exchange of virtual phonons, overcoming the strong Coulomb repulsion to form Cooper pairs. Light is also known to interact with atomic vibrations, as, for example, in the Raman effect. We show that photon pairs exchange virtual vibrations in transparent media, leading to an effective photon-photon interaction identical to that for electrons in the BCS theory of superconductivity, in spite of the fact that photons are bosons...
November 10, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29209787/-different-levels-of-experience-with-anesthetic-agents-of-german-emergency-physicians-results-of-an-online-survey
#18
A Luckscheiter, M Fischer, W Zink
BACKGROUND AND OBJECTIVE: In 2015 practice management guidelines on prehospital emergency anesthesia in adults were published in Germany. The aim of the present study was to evaluate whether emergency physicians follow these guidelines in daily practice and to assess their level of experience with the use of anesthetic agents. MATERIAL AND METHODS: In an online survey the way of induction of preclinical anesthesia (including preoxygenation time and applied monitoring techniques) was assessed with the help of virtual scenarios based on the guidelines...
December 5, 2017: Der Anaesthesist
https://www.readbyqxmd.com/read/29197513/exploration-of-mycobacterium-tuberculosis-structural-proteome-an-in-silico-approach
#19
Mohsin Yousuf Lone, Sivakumar Prasanth Kumar, Mohd Athar, Prakash Chandra Jha
Pharmacophore approaches are of central contour in drug discovery. However, the dependence of ligand-based pharmacophore model on appropriate training set molecules and typical use of apo-protein or single protein-ligand complex for the construction of structure-based pharmacophore models might skip some vital information. Therefore, multiple-complex based approach was employed for the construction of pharmacophore models of the Mycobacterium structural proteome. Moreover, the strategy of clustering of common pharmacophore hypothesis was made to gain an insight about the pharmacophore-similarity across the protein classes and share of features among the inhibitors...
November 29, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29195210/influence-of-undergraduate-nursing-student-teaching-methods-on-learning-standard-precautions-and-transmission-based-precautions-experimental-research
#20
Maria Soledad Kappes Ramirez
OBJECTIVES: An experimental study was performed with undergraduate nursing students in order to determine, between two methodologies, which is the best for learning standard precautions and precautions based on disease transmission mechanisms. METHODS: Students in the sample are stratified by performance, with the experimental group (49 students) being exposed to self-instruction and clinical simulation on the topic of standard precautions and special precautions according to disease transmission mechanisms...
November 15, 2017: Nurse Education Today
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