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https://www.readbyqxmd.com/read/28064082/novel-flavonol-analogues-as-potential-inhibitors-of-jmjd3-histone-demethylase-a-study-based-on-molecular-modelling
#1
Sanchari Basu Mallik, Aravinda Pai, Rekha R Shenoy, B S Jayashree
Epigenetic modulation of gene expression has drawn enormous attention among researchers globally in the present scenario. Since their discovery, Jmj-C histone demethylases were identified as useful markers in understanding the role of epigenetics in inflammatory conditions and in cancer as well. This has created arousal of interest in search of suitable candidates. Potential inhibitors from various other scaffolds such as hydroxyquinolines, hydroxamic acids and triazolopyridines have already been identified and reported...
December 13, 2016: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28057048/a-preliminary-study-of-a-novel-emergency-department-nursing-triage-simulation-for-research-applications
#2
Steven L Dubovsky, Daniel Antonius, David G Ellis, Werner Ceusters, Robert C Sugarman, Renee Roberts, Sevie Kandifer, James Phillips, Elsa C Daurignac, Kenneth E Leonard, Lisa D Butler, Jessica P Castner, G Richard Braen
BACKGROUND: Studying the effect on functioning of the emergency department of disasters with a potential impact on staff members themselves usually involves table top and simulated patient exercises. Computerized virtual reality simulations have the potential to configure a variety of scenarios to determine likely staff responses and how to address them without intensive utilization of resources. To decide whether such studies are justified, we determined whether a novel computer simulation has the potential to serve as a valid and reliable model of on essential function in a busy ED...
January 3, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28050902/erythrocyte-membrane-coated-upconversion-nanoparticles-with-minimal-protein-adsorption-for-enhanced-tumor-imaging
#3
Lang Rao, Qian-Fang Meng, Lin-Lin Bu, Bo Cai, Qinqin Huang, Zhi-Jun Sun, Wen-Feng Zhang, Andrew Li, Shi-Shang Guo, Wei Liu, Tza-Huei Wang, Xing-Zhong Zhao
Upconversion nanoparticles (UCNPs) with superior optical and chemical features have been broadly employed for in vivo cancer imaging. Generally, UCNPs are surface modified with ligands for cancer active targeting. However, nanoparticles in biological fluids are known to form a long-lived "protein corona", which covers the targeting ligands on nanoparticle surface and dramatically reduces the nanoparticle targeting capabilities. Here, for the first time, we demonstrated that by coating UCNPs with red blood cell (RBC) membranes, the resulting cell membrane-capped nanoparticles (RBC-UCNPs) adsorbed virtually no proteins when exposed to human plasma...
January 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28047339/tu-ab-202-03-prediction-of-pet-transfer-uncertainty-by-dir-error-estimating-software-autodirect
#4
H Kim, J Chen, J Phillips, N Kirby
PURPOSE: Deformable image registration (DIR) is a powerful tool, but DIR errors can adversely affect its clinical applications. To estimate voxel-specific DIR uncertainty, a software tool, called AUTODIRECT (automated DIR evaluation of confidence tool), has been developed and validated. This work tests the ability of this software to predict uncertainty for the transfer of standard uptake values (SUV) from positron-emission tomography (PET) with DIR. METHODS: Virtual phantoms are used for this study...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047227/su-c-brb-05-determining-the-adequacy-of-auto-contouring-via-probabilistic-assessment-of-ensuing-treatment-plan-metrics-in-comparison-with-manual-contours
#5
H Nourzadeh, W Watkins, J Siebers, M Ahmad
PURPOSE: To determine if auto-contour and manual-contour-based plans differ when evaluated with respect to probabilistic coverage metrics and biological model endpoints for prostate IMRT. METHODS: Manual and auto-contours were created for 149 CT image sets acquired from 16 unique prostate patients. A single physician manually contoured all images. Auto-contouring was completed utilizing Pinnacle's Smart Probabilistic Image Contouring Engine (SPICE). For each CT, three different 78 Gy/39 fraction 7-beam IMRT plans are created; PD with drawn ROIs, PAS with auto-contoured ROIs, and PM with auto-contoured OARs with the manually drawn target...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047059/th-cd-207a-06-optimizing-four-dimensional-digital-tomosynthesis-acquisition-based-on-respiratory-guidance
#6
D Kim, S Lee, S Kim, S Kang, T Kim, K Kim, M Cho, D Shin, Y Noh, T Suh
PURPOSE: Patient breathing-related sorting method of projections in 4D digital tomosythesis (DTS) can be suffered from severe artifacts due to non-uniform angle distribution of projections and noncoplanar reconstructed images for each phase. In this study, we propose a method for optimally acquiring projection images in 4D DTS. METHODS: In this method every pair of projections at x-ray tube's gantry angles symmetrical with respect to the center of the range of gantry rotation is obtained at the same respiration amplitude...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046542/th-ab-bra-08-simulated-tumor-tracking-in-an-mri-linac-for-lung-tumor-lesions-using-the-monaco-treatment-planning-system
#7
S Al-Ward, A Kim, C McCann, M Ruschin, P Cheung, A Sahgal, B Keller
PURPOSE: To simulate tumor tracking in an Elekta MRI-linac (MRL) and to compare this tracking method with our current ITV approach in terms of OAR sparing for lung cancer patients. METHODS: Five SABR-NSCLC patients with central lung tumors were selected for reasons of potential enhancement of tumor-tissue delineation using MRI. The Monaco TPS was used to compare the current clinical ITV approach to a simulated, novel tracking method which used a 7MV MRL beam in the presence of an orthogonal 1...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28045895/a-framework-for-analyzing-the-whole-body-surface-area-from-a-single-view
#8
Marco Piccirilli, Gianfranco Doretto, Donald Adjeroh
We present a virtual reality (VR) framework for the analysis of whole human body surface area. Usual methods for determining the whole body surface area (WBSA) are based on well known formulae, characterized by large errors when the subject is obese, or belongs to certain subgroups. For these situations, we believe that a computer vision approach can overcome these problems and provide a better estimate of this important body indicator. Unfortunately, using machine learning techniques to design a computer vision system able to provide a new body indicator that goes beyond the use of only body weight and height, entails a long and expensive data acquisition process...
2017: PloS One
https://www.readbyqxmd.com/read/28045634/an-accurate-method-of-designing-and-performing-individual-specific-genioglossus-advancement
#9
Stanley Yung-Chuan Liu, Leh-Kiong Huon, Soroush Zaghi, Robert Riley, Carlos Torre
There is too much individual patient variation in mandibular anatomy for any single described genioglossus advancement technique to be used consistently. Virtual surgical planning allows surgeons to design genioglossus osteotomy that captures the structures of interest. Intraoperative osteotomy and positioning guides mitigate known risks of the procedure while maximizing the reproducibility and efficacy of the procedure. In this report, we demonstrate the protocol step by step as it had been used on 10 patients, and we highlight 3 clinical scenarios that exemplify its utility...
January 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28045533/computational-model-of-secondary-palate-fusion-and-disruption
#10
M Shane Hutson, Maxwell C K Leung, Nancy Baker, Richard M Spencer, Thomas B Knudsen
Morphogenetic events are driven by cell-generated physical forces and complex cellular dynamics. To improve our capacity to predict developmental effects from chemical-induced cellular alterations, we built a multi-cellular agent-based model in CompuCell3D that recapitulates the cellular networks and collective cell behavior underlying growth and fusion of the mammalian secondary palate. The model incorporated multiple signaling pathways (TGFβ, BMP, FGF, EGF, SHH) in a biological framework to recapitulate morphogenetic events from palatal outgrowth through midline fusion...
January 3, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28043070/opportunities-and-limitations-for-intersection-collision-intervention-a-study-of-real-world-left-turn-across-path-accidents
#11
Ulrich Sander
Turning across the path of oncoming vehicle accidents are frequent and dangerous. To date not many car manufacturers have introduced Automated Emergency Braking (AEB) systems addressing this type of conflict situation, but it is foreseeable that these scenarios will be part of the Euro NCAP 2020 rating. Nine out of ten collisions are caused by the driver of the turning vehicle. An AEB system evaluating the ego and conflict vehicle driver's possibilities to avoid a pending crash by either braking or steering was specified for application in various constellations of vehicle collisions...
December 30, 2016: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28039649/or-fire-virtual-training-simulator-design-and-face-validity
#12
Denis Dorozhkin, Jaisa Olasky, Daniel B Jones, Steven D Schwaitzberg, Stephanie B Jones, Caroline G L Cao, Marcos Molina, Steven Henriques, Jinling Wang, Jeff Flinn, Suvranu De
BACKGROUND: The Virtual Electrosurgical Skill Trainer is a tool for training surgeons the safe operation of electrosurgery tools in both open and minimally invasive surgery. This training includes a dedicated team-training module that focuses on operating room (OR) fire prevention and response. The module was developed to allow trainees, practicing surgeons, anesthesiologist, and nurses to interact with a virtual OR environment, which includes anesthesia apparatus, electrosurgical equipment, a virtual patient, and a fire extinguisher...
December 30, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/28027185/use-of-virtual-surgical-planning-for-simultaneous-maxillofacial-osteotomies-and-custom-polyetheretherketone-implant-in-secondary-orbito-frontal-reconstruction-importance-of-restoring-orbital-volume
#13
Neel Patel, Beomjune Kim, Waleed Zaid
Correction of orbito-frontal defects involves a multitude of surgical challenges, and requires careful and detailed planning. In the trauma setting, one must be prepared to deal with injuries to adjacent structures and be able to incorporate their repair into the surgical plan to maximize the functional and esthetic reconstruction for the benefit of the patient. Victims who have sustained trauma of the cranial complex in combination with mid-facial trauma, particularly involving the orbit, present a difficult scenario, especially when future ocular prosthetic rehabilitation is a concern...
December 23, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28006071/lightness-perception-for-surfaces-moving-through-different-illumination-levels
#14
Matteo Toscani, Suncica Zdravkovic, Karl R Gegenfurtner
Lightness perception has mainly been studied with static scenes so far. This study presents four experiments investigating lightness perception under dynamic illumination conditions. We asked participants for lightness matches of a virtual three-dimensional target moving through a light field while their eye movements were recorded. We found that the target appeared differently, depending on the direction of motion in the light field and its precise position in the light field. Lightness was also strongly affected by the choice of fixation positions with the spatiotemporal image sequence...
December 1, 2016: Journal of Vision
https://www.readbyqxmd.com/read/28005453/can-we-study-autonomous-driving-comfort-in-moving-base-driving-simulators-a-validation-study
#15
Hanna Bellem, Malte Klüver, Michael Schrauf, Hans-Peter Schöner, Heiko Hecht, Josef F Krems
OBJECTIVE: To lay the basis of studying autonomous driving comfort using driving simulators, we assessed the behavioral validity of two moving-base simulator configurations by contrasting them with a test-track setting. BACKGROUND: With increasing level of automation, driving comfort becomes increasingly important. Simulators provide a safe environment to study perceived comfort in autonomous driving. To date, however, no studies were conducted in relation to comfort in autonomous driving to determine the extent to which results from simulator studies can be transferred to on-road driving conditions...
December 1, 2016: Human Factors
https://www.readbyqxmd.com/read/28003175/design-of-a-serious-game-for-handling-obstetrical-emergencies
#16
Estelle Jean Dit Gautier, Virginie Bot-Robin, Aurélien Libessart, Guillaume Doucède, Michel Cosson, Chrystèle Rubod
BACKGROUND: The emergence of new technologies in the obstetrical field should lead to the development of learning applications, specifically for obstetrical emergencies. Many childbirth simulations have been recently developed. However, to date none of them have been integrated into a serious game. OBJECTIVE: Our objective was to design a new type of immersive serious game, using virtual glasses to facilitate the learning of pregnancy and childbirth pathologies...
December 21, 2016: JMIR Serious Games
https://www.readbyqxmd.com/read/28000926/virtual-reality-for-rehabilitation-in-parkinson-s-disease
#17
REVIEW
Kim Dockx, Esther Mj Bekkers, Veerle Van den Bergh, Pieter Ginis, Lynn Rochester, Jeffrey M Hausdorff, Anat Mirelman, Alice Nieuwboer
BACKGROUND: Parkinson's disease (PD) is a neurodegenerative disorder that is best managed by a combination of medication and regular physiotherapy. In this context, virtual reality (VR) technology is proposed as a new rehabilitation tool with a possible added value over traditional physiotherapy approaches. It potentially optimises motor learning in a safe environment, and by replicating real-life scenarios could help improve functional activities of daily living. OBJECTIVES: The objective of this review was to summarise the current best evidence for the effectiveness of VR interventions for the rehabilitation of people with PD in comparison with 1) active interventions, and 2) passive interventions...
December 21, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27999538/robotic-and-virtual-reality-bcis-using-spatial-tactile-and-auditory-oddball-paradigms
#18
REVIEW
Tomasz M Rutkowski
The paper reviews nine robotic and virtual reality (VR) brain-computer interface (BCI) projects developed by the author, in collaboration with his graduate students, within the BCI-lab research group during its association with University of Tsukuba, Japan. The nine novel approaches are discussed in applications to direct brain-robot and brain-virtual-reality-agent control interfaces using tactile and auditory BCI technologies. The BCI user intentions are decoded from the brainwaves in realtime using a non-invasive electroencephalography (EEG) and they are translated to a symbiotic robot or virtual reality agent thought-based only control...
2016: Frontiers in Neurorobotics
https://www.readbyqxmd.com/read/27997412/how-can-we-use-computational-modeling-to-improve-total-knee-arthroplasty-modeling-stability-and-mobility-in-the-implanted-knee
#19
Paul J Rullkoetter, Clare K Fitzpatrick, Chadd W Clary
Validated computational models promise a virtual platform to create optimal articular surfaces that best achieve desired implant characteristics. Today, designers can parametrically define the primary geometric features of an implant, and automatically modify design variables until stability/mobility performance objectives are best achieved. This preclinical, virtual design iteration minimizes the development cycle compared with testing physical prototypes and, by evaluating a broader scope of design concepts, likely improves the clinical performance of the final product...
December 16, 2016: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/27955716/development-and-feasibility-of-a-virtual-reality-task-for-the-cognitive-assessment-of-older-adults-the-eco-vr
#20
Camila R Oliveira, Brandel José P Lopes Filho, Michael A Sugarman, Cristiane S Esteves, Margarida Maria B M P Lima, Carmen Moret-Tatay, Tatiana Q Irigaray, Irani Iracema L Argimon
Cognitive assessment with virtual reality (VR) may have superior ecological validity for older adults compared to traditional pencil-and-paper cognitive assessment. However, few studies have reported the development of VR tasks. The aim of this study was to present the development, feasibility, content validity, and preliminary evidence of construct validity of an ecological task of cognitive assessment for older adults in VR (ECO-VR). The tasks were prepared based on theoretical and clinical backgrounds. We had 29 non-expert judges identify virtual visual stimuli and three-dimensional scenarios, and five expert judges assisted with content analysis and developing instructions...
December 13, 2016: Spanish Journal of Psychology
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