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https://www.readbyqxmd.com/read/28435854/a-clinical-trial-simulation-evaluating-epinephrine-pharmacokinetics-at-various-dosing-frequencies-during-cardiopulmonary-resuscitation
#1
Andy R Eugene
OBJECTIVE: This article seeks to test the hypothesis that repeated 1mg intravenous epinephrine dosing intervals of 3-minutes and 5-minutes results in differences in the total drug exposure and the maximum epinephrine concentration using simulated cardiopulmonary resuscitation (CPR) dosing. METHODS: Published population pharmacokinetic parameters were identified in the literature and pharmacokinetic dosing simulations were conducted according to the 2015 American Heart Association guidelines for CPR in adults...
June 2016: MEDtube Science
https://www.readbyqxmd.com/read/28430155/dynamic-construction-scheme-for-virtualization-security-service-in-software-defined-networks
#2
Zhaowen Lin, Dan Tao, Zhenji Wang
For a Software Defined Network (SDN), security is an important factor affecting its large-scale deployment. The existing security solutions for SDN mainly focus on the controller itself, which has to handle all the security protection tasks by using the programmability of the network. This will undoubtedly involve a heavy burden for the controller. More devastatingly, once the controller itself is attacked, the entire network will be paralyzed. Motivated by this, this paper proposes a novel security protection architecture for SDN...
April 21, 2017: Sensors
https://www.readbyqxmd.com/read/28424602/assessing-the-driver-s-current-level-of-working-memory-load-with-high-density-functional-near-infrared-spectroscopy-a-realistic-driving-simulator-study
#3
Anirudh Unni, Klas Ihme, Meike Jipp, Jochem W Rieger
Cognitive overload or underload results in a decrease in human performance which may result in fatal incidents while driving. We envision that driver assistive systems which adapt their functionality to the driver's cognitive state could be a promising approach to reduce road accidents due to human errors. This research attempts to predict variations of cognitive working memory load levels in a natural driving scenario with multiple parallel tasks and to reveal predictive brain areas. We used a modified version of the n-back task to induce five different working memory load levels (from 0-back up to 4-back) forcing the participants to continuously update, memorize, and recall the previous 'n' speed sequences and adjust their speed accordingly while they drove for approximately 60 min on a highway with concurrent traffic in a virtual reality driving simulator...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28422323/validating-a-virtual-environment-for-sexual-assault-victims
#4
Claudie Loranger, Stéphane Bouchard
Virtual reality has shown promising results in the treatment of posttraumatic stress disorder (PTSD) for some traumatic experiences, but sexual assault has been understudied. One important question to address is the relevance and safety of a virtual environment (VE) allowing patients to be progressively exposed to a sexual assault scenario. The aim of this study was to validate such a VE. Thirty women (victims and nonvictims of sexual assault) were randomly assigned in a counter-balanced order to 2 immersions in a virtual bar: a control scenario where the encounter with the aggressor does not lead to sexual assault and an experimental scenario where the participant is assaulted...
April 19, 2017: Journal of Traumatic Stress
https://www.readbyqxmd.com/read/28412441/noise-robust-cortical-tracking-of-attended-speech-in-real-world-acoustic-scenes
#5
Søren Asp Fuglsang, Torsten Dau, Jens Hjortkjær
Selectively attending to one speaker in a multi-speaker scenario is thought to synchronize low-frequency cortical activity to the attended speech signal. In recent studies, reconstruction of speech from single-trial electroencephalogram (EEG) data has been used to decode which talker a listener is attending to in a two-talker situation. It is currently unclear how this generalizes to more complex sound environments. Behaviorally, speech perception is robust to the acoustic distortions that listeners typically encounter in everyday life, but it is unknown whether this is mirrored by a noise-robust neural tracking of attended speech...
April 12, 2017: NeuroImage
https://www.readbyqxmd.com/read/28404465/tool-for-decision-making-regarding-general-evacuation-during-a-rapid-river-flood
#6
V Radosavljevic, G Belojevic, N Pavlovic
OBJECTIVES: To propose a simple and effective tool for decision-making regarding general evacuation during a rapid river flood. STUDY DESIGN: Virtual testing of a tool in a real event. METHOD: A four-component tool was applied to build an alternative scenario of the catastrophic river flood in Obrenovac, Serbia, on May 2014. The components of this tool are: (1) the amount of precipitation above the 95th percentile of all previous measurements; (2) upstream river discharge above the 95th percentile of all previous measurements; (3) upstream river level above the 95th percentile of all previous measurements; and (4) worsening of the hydrometeorological situation in the following 48 h...
February 23, 2017: Public Health
https://www.readbyqxmd.com/read/28399463/distraction-or-cognitive-overload-using-modulations-of-the-autonomic-nervous-system-to-discriminate-the-possible-negative-effects-of-advanced-assistance-system
#7
D Ruscio, A J Bos, M R Ciceri
The interaction with Advanced Driver Assistance Systems has several positive implications for road safety, but also some potential downsides such as mental workload and automation complacency. Malleable attentional resources allocation theory describes two possible processes that can generate workload in interaction with advanced assisting devices. The purpose of the present study is to determine if specific analysis of the different modalities of autonomic control of nervous system can be used to discriminate different potential workload processes generated during assisted-driving tasks and automation complacency situations...
April 8, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28391207/evaluation-of-wearable-haptic-systems-for-the-fingers-in-augmented-reality-applications
#8
Maurizio Maisto, Claudio Pacchierotti, Francesco Chinello, Gionata Salvietti, Alessandro De Luca, Domenico Prattichizzo
Although Augmented Reality (AR) has been around for almost five decades, only recently we have witnessed AR systems and applications entering in our everyday life. Representative examples of this technological revolution are the smartphone games "Pok´emon GO" and "Ingress" or the Google Translate real-time sign interpretation app. Even if AR applications are already quite compelling and widespread, users are still not able to physically interact with the computer-generated reality. In this respect, wearable haptics can provide the compelling illusion of touching the superimposed virtual objects without constraining the motion or the workspace of the user...
April 5, 2017: IEEE Transactions on Haptics
https://www.readbyqxmd.com/read/28391197/virtual-character-animation-based-on-affordable-motion-capture-and-reconfigurable-tangible-interfaces
#9
Fabrizio Lamberti, Gianluca Paravati, Valentina Gatteschi, Alberto Cannavo, Paolo Montuschi
Software for computer animation is generally characterized by a steep learning curve, due to the entanglement of both sophisticated techniques and interaction methods required to control 3D geometries. This paper proposes a tool designed to support computer animation production processes by leveraging the affordances offered by articulated tangible user interfaces and motion capture retargeting solutions. To this aim, orientations of an instrumented prop are recorded together with animator's motion in the 3D space and used to quickly pose characters in the virtual environment...
April 3, 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/28390002/a-tool-for-validating-mri-guided-strategies-a-digital-breathing-ct-mri-phantom-of-the-abdominal-site
#10
Chiara Paganelli, Paul Summers, Chiara Gianoli, Massimo Bellomi, Guido Baroni, Marco Riboldi
Dynamic magnetic resonance imaging (MRI) is emerging as the elected image modality for organ motion quantification and management in image-guided radiotherapy. However, the lack of validation tools is an open issue for image guidance in the abdominal and thoracic organs affected by organ motion due to respiration. We therefore present an abdominal four-dimensional (4D) CT/MRI digital phantom, including the estimation of MR tissue parameters, simulation of dedicated abdominal MR sequences, modeling of radiofrequency coil response and noise, followed by k-space sampling and image reconstruction...
April 8, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/28389794/construct-and-face-validity-of-the-educational-computer-based-environment-ece-assessment-scenarios-for-basic-endoneurosurgery-skills
#11
Nergiz Ercil Cagiltay, Erol Ozcelik, Gokhan Sengul, Mustafa Berker
BACKGROUND: In neurosurgery education, there is a paradigm shift from time-based training to criterion-based model for which competency and assessment becomes very critical. Even virtual reality simulators provide alternatives to improve education and assessment in neurosurgery programs and allow for several objective assessment measures, there are not many tools for assessing the overall performance of trainees. This study aims to develop and validate a tool for assessing the overall performance of participants in a simulation-based endoneurosurgery training environment...
April 7, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28382001/addressing-adherence-using-genotype-specific-pbpk-modeling-impact-of-drug-holidays-on-tamoxifen-and-endoxifen-plasma-levels
#12
Kristin J R Dickschen, Stefan Willmann, Georg Hempel, Michael Block
Introduction: Tamoxifen is one of the most common treatment opportunities for hormonal positive breast cancer. Despite its good tolerability, patients demonstrate decreasing adherence over years impacting on therapeutic success. PBPK modeling was applied to demonstrate the impact of drug holidays on plasma levels of tamoxifen and its active metabolite endoxifen for different CYP2D6 genotypes. Materials and Methods: A virtual study with 24,000 patients was conducted in order to investigate the development of tamoxifen steady-state kinetics in patient groups of different CYP2D6 genotypes...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28361738/simplifying-study-of-fever-s-dramatic-relief-of-autistic-behavior
#13
REVIEW
Peter Good
Dramatic relief of autistic behavior by infectious fever continues to tantalize parents and practitioners, yet researchers still hesitate to study its physiology/biochemistry, fearing stress and heat of brain imaging, contagion, and fever's complexity. Yet what could be more revealing than a common event that virtually 'normalizes' autistic behavior for a time? This paper proposes study of three simplified scenarios: (1) improvements appearing hours before fever, (2) return of autistic behavior soon after fever, (3) improvements persisting long after fever...
February 2017: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28329023/hydro-wind-and-solar-power-as-a-base-for-a-100-renewable-energy-supply-for-south-and-central-america
#14
Larissa de Souza Noel Simas Barbosa, Dmitrii Bogdanov, Pasi Vainikka, Christian Breyer
Power systems for South and Central America based on 100% renewable energy (RE) in the year 2030 were calculated for the first time using an hourly resolved energy model. The region was subdivided into 15 sub-regions. Four different scenarios were considered: three according to different high voltage direct current (HVDC) transmission grid development levels (region, country, area-wide) and one integrated scenario that considers water desalination and industrial gas demand supplied by synthetic natural gas via power-to-gas (PtG)...
2017: PloS One
https://www.readbyqxmd.com/read/28328291/evaluation-of-multi-parameter-test-statistics-for-multiple-imputation
#15
Yu Liu, Craig K Enders
In Ordinary Least Square regression, researchers often are interested in knowing whether a set of parameters is different from zero. With complete data, this could be achieved using the gain in prediction test, hierarchical multiple regression, or an omnibus F test. However, in substantive research scenarios, missing data often exist. In the context of multiple imputation, one of the current state-of-art missing data strategies, there are several different analogous multi-parameter tests of the joint significance of a set of parameters, and these multi-parameter test statistics can be referenced to various distributions to make statistical inferences...
March 22, 2017: Multivariate Behavioral Research
https://www.readbyqxmd.com/read/28316122/digital-workflow-for-fixed-implant-rehabilitation-of-an-extremely-atrophic-edentulous-mandible-in-three-appointments
#16
Panos Papaspyridakos, Neha Rajput, Yukio Kudara, Hans-Peter Weber
OBJECTIVE: To present a rationale to reduce treatment complexity, number of surgeries, and overall treatment time for patients with extreme mandibular ridge deficiency. CLINICAL CONSIDERATIONS: A 67-year-old fully edentulous male presented with a chief complaint of poor retention and stability of the mandibular complete denture with consequent discomfort and inability to chew. A novel 3-appointment protocol from guided implant placement to definitive prosthesis delivery was implemented...
March 18, 2017: Journal of Esthetic and Restorative Dentistry
https://www.readbyqxmd.com/read/28315607/correcting-bias-due-to-missing-stage-data-in-the-non-parametric-estimation-of-stage-specific-net-survival-for-colorectal-cancer-using-multiple-imputation
#17
Milena Falcaro, James R Carpenter
BACKGROUND: Population-based net survival by tumour stage at diagnosis is a key measure in cancer surveillance. Unfortunately, data on tumour stage are often missing for a non-negligible proportion of patients and the mechanism giving rise to the missingness is usually anything but completely at random. In this setting, restricting analysis to the subset of complete records gives typically biased results. Multiple imputation is a promising practical approach to the issues raised by the missing data, but its use in conjunction with the Pohar-Perme method for estimating net survival has not been formally evaluated...
March 15, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28298429/speciation-network-in-laurasiatheria-retrophylogenomic-signals
#18
Liliya Doronina, Gennady Churakov, Andrej Kuritzin, Jingjing Shi, Robert Baertsch, Hiram Clawson, Juergen Schmitz
Rapid species radiation due to adaptive changes or occupation of new ecospaces challenges our understanding of ancestral speciation and the relationships of modern species. At the molecular level, rapid radiation with successive speciations over short time periods - too short to fix polymorphic alleles - is described as incomplete lineage sorting. Incomplete lineage sorting leads to random fixation of genetic markers and hence random signals of relationships in phylogenetic reconstructions. The situation is further complicated when you consider that the genome is a mosaic of ancestral and modern incompletely sorted sequence blocks that leads to reconstructed affiliations to one or the other relatives depending on the fixation of their shared ancestral polymorphic alleles...
March 15, 2017: Genome Research
https://www.readbyqxmd.com/read/28294207/selecting-the-appropriate-digital-planning-pathway-%C3%A2-for-computer-guided-implant-surgery
#19
Alejandro Lanis, Pablo Llorens, Orlando Álvarez Del Canto
The incorporation of virtual engineering into our profession and the digitalization of information are allowing us new perspectives and innovative alternatives for dental treatment modalities. The use of computer-guided implant-planning software allows the radiographic, prosthetic, surgical, and laboratory fields to be combined under a common virtual scenario, permitting complete virtual treatment planning. Different alternatives for the digital workflow have been described for computer-guided implant placement...
2017: International Journal of Computerized Dentistry
https://www.readbyqxmd.com/read/28292706/effect-of-airflow-and-material-models-on-tissue-displacement-for-surgical-planning-of-pharyngeal-airways-in-pediatric-down-syndrome-patients
#20
Dhananjay Radhakrishnan Subramaniam, Goutham Mylavarapu, Robert J Fleck, Raouf S Amin, Sally R Shott, Ephraim J Gutmark
Pharyngeal narrowing in obstructive sleep apnea (OSA) results from flow-induced displacement of soft tissue. The objective of this study is to evaluate the effect of airflow parameters and material model on soft tissue displacement for planning surgical treatment in pediatric patients with OSA and Down syndrome (DS). Anatomically accurate, three-dimensional geometries of the pharynx and supporting tissue were reconstructed for one pediatric OSA patient with DS using magnetic resonance images. Six millimeters of adenoid tissue was virtually removed based on recommendations from the surgeon, to replicate the actual adenoidectomy...
March 8, 2017: Journal of the Mechanical Behavior of Biomedical Materials
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