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https://www.readbyqxmd.com/read/28615276/bluehealth-a-study-programme-protocol-for-mapping-and-quantifying-the-potential-benefits-to-public-health-and-well-being-from-europe-s-blue-spaces
#1
James Grellier, Mathew P White, Maria Albin, Simon Bell, Lewis R Elliott, Mireia Gascón, Silvio Gualdi, Laura Mancini, Mark J Nieuwenhuijsen, Denis A Sarigiannis, Matilda van den Bosch, Tanja Wolf, Susanne Wuijts, Lora E Fleming
INTRODUCTION: Proximity and access to water have long been central to human culture and accordingly deliver countless societal benefits. Over 200 million people live on Europe's coastline, and aquatic environments are the top recreational destination in the region. In terms of public health, interactions with 'blue space' (eg, coasts, rivers, lakes) are often considered solely in terms of risk (eg, drowning, microbial pollution). Exposure to blue space can, however, promote health and well-being and prevent disease, although underlying mechanisms are poorly understood...
June 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/28604803/impact-of-tumor-position-conductivity-distribution-and-tissue-homogeneity-on-the-distribution-of-tumor-treating-fields-in-a-human-brain-a-computer-modeling-study
#2
Anders Rosendal Korshoej, Frederik Lundgaard Hansen, Axel Thielscher, Gorm Burckhardt von Oettingen, Jens Christian Hedemann Sørensen
BACKGROUND: Tumor treating fields (TTFields) are increasingly used in the treatment of glioblastoma. TTFields inhibit cancer growth through induction of alternating electrical fields. To optimize TTFields efficacy, it is necessary to understand the factors determining the strength and distribution of TTFields. In this study, we provide simple guiding principles for clinicians to assess the distribution and the local efficacy of TTFields in various clinical scenarios. METHODS: We calculated the TTFields distribution using finite element methods applied to a realistic head model...
2017: PloS One
https://www.readbyqxmd.com/read/28587246/proof-of-concept-of-home-iot-connected-vehicles
#3
Younsun Kim, Hyunggoy Oh, Sungho Kang
The way in which we interact with our cars is changing, driven by the increased use of mobile devices, cloud-based services, and advanced automotive technology. In particular, the requirements and market demand for the Internet of Things (IoT) device-connected vehicles will continuously increase. In addition, the advances in cloud computing and IoT have provided a promising opportunity for developing vehicular software and services in the automotive domain. In this paper, we introduce the concept of a home IoT connected vehicle with a voice-based virtual personal assistant comprised of a vehicle agent and a home agent...
June 5, 2017: Sensors
https://www.readbyqxmd.com/read/28586732/the-virtual-approach-to-the-assessment-of-skeletal-injuries-in-human-skeletal-remains-of-forensic-importance
#4
Petra Urbanová, Ann H Ross, Mikoláš Jurda, Ivana Šplíchalová
While assessing skeletal injuries in human skeletal remains, forensic anthropologists are frequently presented with fractured, fragmented, or otherwise modified skeletal remains. The examination of evidence and the mechanisms of skeletal injuries often require that separate osseous elements be permanently or temporarily reassembled or reconstructed. If not dealt with properly, such reconstructions may impede accurate interpretation of the evidence. Nowadays, routine forensic examinations increasingly incorporate digital imaging technologies...
July 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/28584867/utilization-and-acceptance-of-virtual-patients-in-veterinary-basic-sciences-the-vetvip-project
#5
Christin Kleinsorgen, Marta Kankofer, Zbigniew Gradzki, Mira Mandoki, Tibor Bartha, Maren von Köckritz-Blickwede, Hassan Y Naim, Martin Beyerbach, Andrea Tipold, Jan P Ehlers
Context: In medical and veterinary medical education the use of problem-based and cased-based learning has steadily increased over time. At veterinary faculties, this development has mainly been evident in the clinical phase of the veterinary education. Therefore, a consortium of teachers of biochemistry and physiology together with technical and didactical experts launched the EU-funded project "vetVIP", to create and implement veterinary virtual patients and problems for basic science instruction. In this study the implementation and utilization of virtual patients occurred at the veterinary faculties in Budapest, Hannover and Lublin...
2017: GMS Journal for Medical Education
https://www.readbyqxmd.com/read/28578015/therapeutic-pro-fibrogenic-signaling-pathways-in-fibroblasts
#6
Stefania Cannito, Erica Novo, Maurizio Parola
Myofibroblasts (MFs) play a critical role in the progression of chronic inflammatory and fibroproliferative diseases in different tissues/organs, whatever the etiology. Fibrosis is preceded and sustained by persistent injury and inflammatory response in a profibrogenic scenario involving mutual interactions, operated by several mediators and pathways, of MFs and related precursor cells with innate immunity cells and virtually any cell type in a defined tissue. These interactions, mediators and related signaling pathways are critical in initiating and perpetuating the differentiation of precursors cells into MFs that in different tissues share peculiar traits and phenotypic responses, including the ability to proliferate, produce ECM components, migrate and contribute to the modulation of inflammatory response and tissue angiogenesis...
May 31, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28577263/modelling-for-the-proposed-roll-out-of-the-111-service-in-wales-a-case-study
#7
Mark Tuson, Tracey England, Doris Behrens, Richard Bowen, Dorothy Edwards, John Frankish, Jude Kay
NHS Direct Wales provides a single point of access where members of the public can telephone and seek medical support and/or advice. The service is provided for all the Health Boards in Wales by a single virtual call centre run from a main location in Swansea with 2 satellite locations. Patients in Wales can also access a local General Practitioner service during the evenings and at weekends, by phoning their Out of Hours service. The introduction of a '111' service is intended to combine these two operations on a pan-Wales basis using the existing NHS Direct Wales call centre and staff, with the existing Health Board Out of Hours 'hubs'...
June 2, 2017: Health Care Management Science
https://www.readbyqxmd.com/read/28576622/haemodynamic-effects-of-stent-diameter-and-compaction-ratio-on-flow-diversion-treatment-of-intracranial-aneurysms-a-numerical-study-of-a-successful-and-an-unsuccessful-case
#8
Mingzi Zhang, Yujie Li, Xi Zhao, David I Verrelli, Winston Chong, Makoto Ohta, Yi Qian
BACKGROUND: Compacting a flow-diverting (FD) stent is an emerging technique to create a denser configuration of wires across the aneurysm ostium. However, quantitative analyses of post-stenting haemodynamics affected by the compaction level of different stent sizes remain inconclusive. OBJECTIVE: To compare the aneurysmal haemodynamic alterations after virtual FD treatments with different device diameters at different compaction ratios. METHODS: We virtually implanted three sizes of FD stent, with each size deployed at four compaction ratios, into two patient aneurysms previously treated with the Silk+FD-one successful case and the other unsuccessful...
May 16, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28556204/optimal-combination-of-anti-scatter-grids-and-software-correction-for-cbct-imaging
#9
Uros Stankovic, Lennert S Ploeger, Marcel van Herk, Jan-Jakob Sonke
PURPOSE: CBCT has been widely adopted in clinical practice for image-guided radiotherapy. Soft tissue contrast and Hounsfield units are impaired to presence of scattered radiation. In our previous work we proposed a high selectivity anti-scatter grid (ASG) as a possible solution to the problem. An alternative approach is the application of iterative scatter correction using deconvolution with scatter point spread function (PSF). The purpose of this work was to compare the performance of ASGs with different selectivity with and without the iterative and uniform scatter corrections in terms of CBCT image quality...
May 29, 2017: Medical Physics
https://www.readbyqxmd.com/read/28554493/statistical-shape-modeling-predicts-patellar-bone-geometry-to-enable-stereo-radiographic-kinematic-tracking
#10
Lowell M Smoger, Kevin B Shelburne, Adam J Cyr, Paul J Rullkoetter, Peter J Laz
Complications in the patellofemoral (PF) joint of patients with total knee replacements include patellar subluxation and dislocation, and remain a cause for revision. Kinematic measurements to assess these complications and evaluate implant designs require the accuracy of dynamic stereo-radiographic systems with 3D-2D registration techniques. While tibiofemoral kinematics are typically derived by tracking metallic implants, PF kinematic measurements are difficult as the patellar implant is radiotransparent and a representation of the resected patella bone requires either pre-surgical imaging and precise implant placement or post-surgical imaging...
May 17, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28547013/new-cfd-tools-to-evaluate-nasal-airflow
#11
M A Burgos, E Sanmiguel-Rojas, C Del Pino, M A Sevilla-García, F Esteban-Ortega
Computational fluid dynamics (CFD) is a mathematical tool to analyse airflow. As currently CFD is not a usual tool for rhinologists, a group of engineers in collaboration with experts in Rhinology have developed a very intuitive CFD software. The program MECOMLAND(®) only required snapshots from the patient's cross-sectional (tomographic) images, being the output those results originated by CFD, such as airflow distributions, velocity profiles, pressure, temperature, or wall shear stress. This is useful complementary information to cover diagnosis, prognosis, or follow-up of nasal pathologies based on quantitative magnitudes linked to airflow...
May 25, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28534770/boscc-bag-of-spatial-context-correlations-for-spatially-enhanced-3d-shape-representation
#12
Zhizhong Han, Zhenbao Liu, Chi-Man Vong, Yu-Shen Liu, Shuhui Bu, Junwei Han, Philip Chen
Highly discriminative 3D shape representations can be formed by encoding the spatial relationship among virtual words into the Bag of Words (BoW) method. To achieve this challenging task, several unresolved issues in the encoding procedure must be overcome for 3D shapes, including i) arbitrary mesh resolution, ii) irregular vertex topology, iii) orientation ambiguity on the 3D surface and iv) invariance to rigid and non-rigid shape transformations. In this work, a novel spatially enhanced 3D shape representation called Bag of Spatial Context Correlations (BoSCC) is proposed to address all these issues...
May 16, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28532974/cost-effectiveness-analysis-of-corneal-collagen-crosslinking-for-progressive-keratoconus
#13
Daniel A Godefrooij, Marie-Josee J Mangen, Elsie Chan, David P S O'Brart, Saskia M Imhof, G Ardine de Wit, Robert P L Wisse
PURPOSE: To evaluate the cost effectiveness of corneal collagen crosslinking (CXL) for progressive keratoconus from the healthcare payer's perspective. DESIGN: A probabilistic Markov-type model using data from published clinical trials and cohort studies. PARTICIPANTS: Two identical cohorts, each comprising 1000 virtual patients with progressive bilateral keratoconus, were modeled; one cohort underwent CXL and the other cohort received no intervention...
May 19, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28527481/rethinking-anatomy-how-to-overcome-challenges-of-medical-education-s-evolution
#14
REVIEW
Bruno Guimarães, Luís Dourado, Stanislav Tsisar, José Miguel Diniz, Maria Dulce Madeira, Maria Amélia Ferreira
INTRODUCTION: Due to scientific and technological development, Medical Education has been readjusting its focus and strategies. Medical curriculum has been adopting a vertical integration model, in which basic and clinical sciences coexist during medical instruction. This context favours the introduction of new complementary technology-based pedagogical approaches. Thus, even traditional core sciences of medical curriculum, like Anatomy, are refocusing their teaching/learning paradigm...
February 27, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28524072/development-of-a-virtual-collision-sensor-for-industrial-robots
#15
Marina Indri, Stefano Trapani, Ivan Lazzero
Collision detection is a fundamental issue for the safety of a robotic cell. While several common methods require specific sensors or the knowledge of the robot dynamic model, the proposed solution is constituted by a virtual collision sensor for industrial manipulators, which requires as inputs only the motor currents measured by the standard sensors that equip a manipulator and the estimated currents provided by an internal dynamic model of the robot (i.e., the one used inside its controller), whose structure, parameters and accuracy are not known...
May 18, 2017: Sensors
https://www.readbyqxmd.com/read/28517911/is-there-a-potential-of-misuse-for-magnolia-officinalis-compounds-metabolites
#16
Fabrizio Schifano, Valentina Guarino, Duccio G Papanti, Jacopo Baccarin, Laura Orsolini, John M Corkery
OBJECTIVE: Magnolia bark contains magnolol, metabolized to tetrahydromagnolol and honokiol, with both GABA-ergic/cannabimimetic activities, hence of possible attraction to vulnerable individuals/recreational misusers. METHODS: A literature review, assessment of related anecdotal online Magnolia misuse's reports and an overview of Magnolia products' online acquisition possibilities has been here described. RESULTS: No peer-reviewed papers about Magnolia abuse/misuse/dependence/addiction were identified...
May 18, 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28516170/mott-physics-beyond-brinkman-rice-scenario
#17
Marcin M Wysokiński, Michele Fabrizio
The main flaw of the well-known Brinkman-Rice description, obtained through the Gutzwiller approximation, of the paramagnetic Mott transition in the Hubbard model is in neglecting high-energy virtual processes that generate for instance the antiferromagnetic exchange J ~ t(2)/U. Here we propose a way to capture those processes by combining the Brinkman-Rice approach with a variational Schrieffer-Wolff transformation, and apply this method to study the single-band metal-to-insulator transition in a Bethe lattice with infinite coordination number, where the Gutzwiller approximation becomes exact...
April 15, 2017: Physical Review. B
https://www.readbyqxmd.com/read/28512256/concomitant-eml4-alk-rearrangement-and-egfr-mutation-in-non-small-cell-lung-cancer-patients-a-literature-review-of-100-cases
#18
REVIEW
Giuseppe Lo Russo, Martina Imbimbo, Giulia Corrao, Claudia Proto, Diego Signorelli, Milena Vitali, Monica Ganzinelli, Laura Botta, Nicoletta Zilembo, Filippo de Braud, Marina Chiara Garassino
The discovery of EGFR mutations and EML4-ALK gene rearrangements has radically changed the therapeutic scenario for patients with advanced non-small cell lung cancer. ALK and EGFR tyrosine-kinase inhibitors showed better activity and efficacy than standard chemotherapy in the first and second line treatment settings, leading to a clear advantage in overall survival of advanced non small cell lung cancer patients harboring these genetic alterations.Historically the coexistence of EGFR mutations and EML4-ALK rearrangements in the same tumor has been described as virtually impossible...
April 26, 2017: Oncotarget
https://www.readbyqxmd.com/read/28503159/quantifying-the-degree-of-movement-dissimilarity-between-two-distinct-action-scenarios-an-exploratory-approach-with-procrustes-analysis
#19
Pedro Passos, Tania Campos, Ana Diniz
Game consoles allow subjects to perform movements which are visually similar to the movements performed in 'real' world scenarios. Beyond entertainment, virtual reality devices are being used in several domains: sports performance; motor rehabilitation; training of risk professions. This article presents the Procrustes method to measure the degree of dissimilarity between movements performed in 'real' and 'virtual' scenarios. For this purpose, the 501 darts game and a video darts game played on a console were used...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28499888/almeria-spatial-memory-recognition-test-asmrt-gender-differences-emerged-in-a-new-passive-spatial-task
#20
Laura Tascón, Luis Miguel García-Moreno, Jose Manuel Cimadevilla
Many different human spatial memory tasks were developed in the last two decades. Virtual reality based tasks make possible developing different scenarios and situations to assess spatial orientation but sometimes these tasks are complex for specific populations like children and older-adults. A new spatial task with a very limited technological requirement was developed in this study. It demanded the use of spatial memory for an accurate solution. It also proved to be sensitive to gender differences, with men outperforming women under high specific difficulty levels...
May 9, 2017: Neuroscience Letters
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