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https://www.readbyqxmd.com/read/28938691/concomitant-eml4-alk-rearrangement-and-egfr-mutation-in-non-small-cell-lung-cancer-patients-a-literature-review-of-100-cases
#1
REVIEW
Giuseppe Lo Russo, Martina Imbimbo, Giulia Corrao, Claudia Proto, Diego Signorelli, Milena Vitali, Monica Ganzinelli, Laura Botta, Nicoletta Zilembo, Filippo de Braud, Marina Chiara Garassino
The discovery of EGFR mutations and EML4-ALK gene rearrangements has radically changed the therapeutic scenario for patients with advanced non-small cell lung cancer. ALK and EGFR tyrosine-kinase inhibitors showed better activity and efficacy than standard chemotherapy in the first and second line treatment settings, leading to a clear advantage in overall survival of advanced non-small cell lung cancer patients harboring these genetic alterations. Historically the coexistence of EGFR mutations and EML4-ALK rearrangements in the same tumor has been described as virtually impossible...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28937772/terahertz-light-matter-interaction-beyond-unity-coupling-strength
#2
Andreas Bayer, Marcel Pozimski, Simon Schambeck, Dieter Schuh, Rupert Huber, Dominique Bougeard, Christoph Lange
Achieving control over light-matter interaction in custom-tailored nanostructures is at the core of modern quantum electrodynamics. In strongly and ultrastrongly coupled systems, the excitation is repeatedly exchanged between a resonator and an electronic transition at a rate known as the vacuum Rabi frequency ΩR. For ΩR approaching the resonance frequency ωc, novel quantum phenomena including squeezed states, Dicke superradiant phase transitions, the collapse of the Purcell effect, and a population of the ground state with virtual photon pairs are predicted...
September 22, 2017: Nano Letters
https://www.readbyqxmd.com/read/28937590/logistic-model-to-support-service-modularity-for-the-promotion-of-reusability-in-a-web-objects-enabled-iot-environment
#3
Muhammad Golam Kibria, Sajjad Ali, Muhammad Aslam Jarwar, Sunil Kumar, Ilyoung Chong
Due to a very large number of connected virtual objects in the surrounding environment, intelligent service features in the Internet of Things requires the reuse of existing virtual objects and composite virtual objects. If a new virtual object is created for each new service request, then the number of virtual object would increase exponentially. The Web of Objects applies the principle of service modularity in terms of virtual objects and composite virtual objects. Service modularity is a key concept in the Web Objects-Enabled Internet of Things (IoT) environment which allows for the reuse of existing virtual objects and composite virtual objects in heterogeneous ontologies...
September 22, 2017: Sensors
https://www.readbyqxmd.com/read/28931497/use-of-simulation-based-on-an-electronic-health-records-environment-to-evaluate-the-structure-and-accuracy-of-notes-generated-by-medical-scribes-proof-of-concept-study
#4
Robert Pranaat, Vishnu Mohan, Megan O'Reilly, Maxwell Hirsh, Karess McGrath, Gretchen Scholl, Deborah Woodcock, Jeffrey A Gold
BACKGROUND: The increasing adoption of electronic health records (EHRs) has been associated with a number of unintended negative consequences with provider efficiency and job satisfaction. To address this, there has been a dramatic increase in the use of medical scribes to perform many of the required EHR functions. Despite this rapid growth, little has been published on the training or assessment tools to appraise the safety and efficacy of scribe-related EHR activities. Given the number of reports documenting that other professional groups suffer from a number of performance errors in EHR interface and data gathering, scribes likely face similar challenges...
September 20, 2017: JMIR Medical Informatics
https://www.readbyqxmd.com/read/28927667/development-and-validation-of-a-tool-to-evaluate-the-evolution-of-clinical-reasoning-in-trauma-using-virtual-patients
#5
David Fleiszer, Michael L Hoover, Nancy Posel, Tarek Razek, Simon Bergman
CONTEXT: Undergraduate medical students at a large academic trauma center are required to manage a series of online virtual trauma patients as a mandatory exercise during their surgical rotation. PURPOSE: Clinical reasoning during undergraduate medical education can be difficult to assess. The purpose of the study was to determine whether we could use components of the students' virtual patient management to measure changes in their clinical reasoning over the course of the clerkship year...
September 16, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28924283/a-framework-for-laparoscopic-simulations
#6
Osman Hasan, Sohail Iqbal
Due to their numerous advantages, laparoscopic surgical procedures are increasingly becoming common in the operation theatres over the past few decades. Virtual reality training simulators have played a significant role during this transition from traditional to laparoscopic procedures by enhancing surgical skills, such as hand-eye coordination in laparoscopy, and practising surgical scenarios that cannot be easily created using physical models. This paper presents a general framework for such a training simulator while identifying its key components and their specific roles in enhancing various laparoscopic skills...
September 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28906450/obstacle-recognition-based-on-machine-learning-for-on-chip-lidar-sensors-in-a-cyber-physical-system
#7
Fernando Castaño, Gerardo Beruvides, Rodolfo E Haber, Antonio Artuñedo
Collision avoidance is an important feature in advanced driver-assistance systems, aimed at providing correct, timely and reliable warnings before an imminent collision (with objects, vehicles, pedestrians, etc.). The obstacle recognition library is designed and implemented to address the design and evaluation of obstacle detection in a transportation cyber-physical system. The library is integrated into a co-simulation framework that is supported on the interaction between SCANeR software and Matlab/Simulink...
September 14, 2017: Sensors
https://www.readbyqxmd.com/read/28902526/driving-performance-after-self-regulated-control-transitions-in-highly-automated-vehicles
#8
Alexander Eriksson, Neville A Stanton
OBJECTIVE: This study aims to explore whether driver-paced, noncritical transitions of control may counteract some of the aftereffects observed in the contemporary literature, resulting in higher levels of vehicle control. BACKGROUND: Research into control transitions in highly automated driving has focused on urgent scenarios where drivers are given a relatively short time span to respond to a request to resume manual control, resulting in seemingly scrambled control when manual control is resumed...
September 1, 2017: Human Factors
https://www.readbyqxmd.com/read/28885874/impact-of-virtual-patients-as-optional-learning-material-in-veterinary-biochemistry-education
#9
Christin Kleinsorgen, Maren von Köckritz-Blickwede, Hassan Y Naim, Katja Branitzki-Heinemann, Marta Kankofer, Míra Mándoki, Martin Adler, Andrea Tipold, Jan P Ehlers
Biochemistry and physiology teachers from veterinary faculties in Hannover, Budapest, and Lublin prepared innovative, computer-based, integrative clinical case scenarios as optional learning materials for teaching and learning in basic sciences. These learning materials were designed to enhance attention and increase interest and intrinsic motivation for learning, thus strengthening autonomous, active, and self-directed learning. We investigated learning progress and success by administering a pre-test before exposure to the virtual patients (vetVIP) cases, offered vetVIP cases alongside regular biochemistry courses, and then administered a complementary post-test...
September 8, 2017: Journal of Veterinary Medical Education
https://www.readbyqxmd.com/read/28853922/origin-and-evolution-of-the-universal-genetic-code
#10
Eugene V Koonin, Artem S Novozhilov
The standard genetic code (SGC) is virtually universal among extant life forms. Although many deviations from the universal code exist, particularly in organelles and prokaryotes with small genomes, they are limited in scope and obviously secondary. The universality of the code likely results from the combination of a frozen accident, i.e., the deleterious effect of codon reassignment in the SGC, and the inhibitory effect of changes in the code on horizontal gene transfer. The structure of the SGC is nonrandom and ensures high robustness of the code to mutational and translational errors...
August 30, 2017: Annual Review of Genetics
https://www.readbyqxmd.com/read/28841448/pre-crash-scenarios-at-road-junctions-a-clustering-method-for-car-crash-data
#11
Philippe Nitsche, Pete Thomas, Rainer Stuetz, Ruth Welsh
Given the recent advancements in autonomous driving functions, one of the main challenges is safe and efficient operation in complex traffic situations such as road junctions. There is a need for comprehensive testing, either in virtual simulation environments or on real-world test tracks. This paper presents a novel data analysis method including the preparation, analysis and visualization of car crash data, to identify the critical pre-crash scenarios at T- and four-legged junctions as a basis for testing the safety of automated driving systems...
October 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28834735/a-photochemical-kinetic-model-for-solid-dosage-forms
#12
Thiago C Carvalho, Thomas E La Cruz, Jose E Tabora
Photochemical kinetics models for pharmaceutical compounds in solution have been extensively investigated, but not in solid phase upon exposure to different light sources. The objective of this study was to develop a mathematical model to describe the solid state photodegradation of pharmaceutical powder materials under different area/volumetric scales and light exposure conditions. The model considered the previous formalism presented for photodegradation kinetics in solution phase with important elements applied to static powder material being irradiated with a polychromatic light source...
August 20, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28829317/multimodal-evaluation-of-the-differences-between-real-and-virtual-assemblies
#13
Mikel Sagardia, Thomas Hulin
What are the technological bottlenecks in virtual assembly simulations with haptic feedback? To tackle this question, we present an evaluation study in which real feedback modalities are gradually replaced by synthetic ones. In particular, the effects of the following factors on the user performance and perception during virtual assemblies are analyzed: (i) a visual feedback system consisting of an nVisor head-mounted display, (ii) our haptic device HUG suited for unscaled upper-body movements, and (iii) our novel six-DoF constraint-based haptic rendering algorithm...
August 18, 2017: IEEE Transactions on Haptics
https://www.readbyqxmd.com/read/28829290/believability-and-co-presence-in-human-virtual-character-interaction
#14
Elisabetta Bevacqua, Romain Richard, Pierre De Loor
Subtle phenomena rooted in our body dynamics affect the reactive and evolutive parts of every human interaction. The authors' decision model allows for adaptive physical interactions between a human and a virtual agent. This article presents an evaluation of that model in terms of agent believability, the user's feeling of co-presence, and overall game experience. The results show that the model can generate adaptive body behavior for virtual agents that is comparable to a human's, but the user and agent roles in each scenario strongly impact the user's perception of the agent...
2017: IEEE Computer Graphics and Applications
https://www.readbyqxmd.com/read/28815754/pharmacokinetic-interactions-and-dosing-rationale-for-antiepileptic-drugs-in-adults-and-children
#15
S C van Dijkman, W M Rauwé, M Danhof, O Della Pasqua
AIM: Population pharmacokinetic modelling has been widely used across many therapeutic areas to identify sources of variability, which are incorporated into models as covariate factors. Despite numerous publications on pharmacokinetic (PK) drug-drug interactions (DDIs) between antiepileptic drugs (AEDs), such data are not used to support the dose rationale for polytherapy in the treatment of epileptic seizures. Here we assess the impact of DDIs on plasma concentrations and evaluate the need for AED dose adjustment...
August 16, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28813911/design-and-kinematic-analysis-of-a-novel-upper-limb-exoskeleton-for-rehabilitation-of-stroke-patients
#16
Amin Zeiaee, Rana Soltani-Zarrin, Reza Langari, Reza Tafreshi
This paper details the design process and features of a novel upper limb rehabilitation exoskeleton named CLEVER (Compact, Low-weight, Ergonomic, Virtual/Augmented Reality Enhanced Rehabilitation) ARM. The research effort is focused on designing a lightweight and ergonomic upper-limb rehabilitation exoskeleton capable of producing diverse and perceptually rich training scenarios. To this end, the knowledge available in the literature of rehabilitation robotics is used along with formal conceptual design techniques...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813855/an-optimized-design-of-a-parallel-robot-for-gait-training
#17
Marco Maddalena, Mozafar Saadat, Alireza Rastegarpanah, Rui C V Loureiro
The guidelines for enhancing robot-assisted training for post-stroke survivors head towards increasing exercise realism and variability; in particular lower limb rehabilitation needs the patient to feel challenged to adapt his locomotion and dynamic balance capabilities to different virtual ground scenarios. This paper proposes a design for a robot whose end-effector acts as a footplate to be in permanent contact with the user's foot during practice: the structure is such that it enables the user's foot to rotate around three axis, differently from what is currently available in the research for gait training; the parallel kinematic structure and the dimensional synthesis allow a suitable range of motion and aim at limiting device mass, footprint and reaction forces on the actuators when rendering virtual ground...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28811246/microbial-metagenomics-mock-scenario-based-sample-simulation-m3s3
#18
Yair Motro, Jacob Moran-Gilad
OBJECTIVES: Shotgun sequencing in increasingly applied in clinical microbiology for unbiased culture-independent diagnosis. While software solutions for metagenomics proliferate, integration of metagenomics in clinical care, requires method standardisation and validation. Virtual metagenomics samples could underpin validation by substituting real samples and thus we sought to develop a novel solution for simulation of metagenomics samples based on user-defined clinical scenarios. METHODS: We designed the Microbial Metagenomics Mock Scenario-based Sample Simulation (M3S3) workflow, which allows users to generate virtual samples from raw reads or assemblies...
August 12, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28805190/driving-force-of-the-orbital-relevant-electronic-nematicity-in-fe-based-superconductors
#19
Tao Li, Yuehua Su
The electronic nematic responses in Fe-based superconductors have been observed ubiquitously in various experimental probes. One novel nematic character is the d-wave bond orbital-relevant nematic charge order which was firstly proposed by symmetry analysis and then conformed by angle-resolved photoemission spectroscopy. In this paper, we present a mechanism that the driving force of the orbital-relevant nematic charge order is the reduction of the large Hubbard energy in the particle-hole charge channel by virtual hopping processes...
August 14, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28802443/controlling-robots-in-the-home-factors-that-affect-the-performance-of-novice-robot-operators
#20
Conor McGinn, Aran Sena, Kevin Kelly
For robots to successfully integrate into everyday life, it is important that they can be effectively controlled by laypeople. However, the task of manually controlling mobile robots can be challenging due to demanding cognitive and sensorimotor requirements. This research explores the effect that the built environment has on the manual control of domestic service robots. In this study, a virtual reality simulation of a domestic robot control scenario was developed. The performance of fifty novice users was evaluated, and their subjective experiences recorded through questionnaires...
November 2017: Applied Ergonomics
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