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https://www.readbyqxmd.com/read/28526451/inter-delivery-weight-gain-and-risk-of-cesarean-delivery-following-a-prior-vaginal-delivery
#1
Annie M Dude, Abbi D Lane-Cordova, William A Grobman
BACKGROUND: Approximately 1/3 of all deliveries in the United States are via cesarean. Previous research indicates weight gain during pregnancy is associated with an increased risk of cesarean delivery. It remains unclear, however, whether and to what degree weight gain between deliveries (i.e., inter-delivery weight gain) is associated with cesarean delivery in a subsequent pregnancy following a vaginal delivery. OBJECTIVES: To determine whether inter-delivery weight gain is associated with an increased risk of intrapartum cesarean delivery following a vaginal delivery...
May 16, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28421614/a-first-look-at-the-effects-of-long-inter-pregnancy-interval-and-advanced-maternal-age-on-perinatal-outcomes-a-retrospective-cohort-study
#2
Chunxiang Qin, Chunmei Mi, Aibin Xia, Wei-Ti Chen, Chunxia Chen, Ying Li, Yao Li, Wenhui Bai, Siyuan Tang
BACKGROUND: After China's One-child Policy was replaced with the Two-child Policy in 2013, the rate of second pregnancies with a longer inter-pregnancy interval (IPI) has suddenly increased in that country; however, the effect of long IPIs (≥49 months) on perinatal outcomes remains unreported. METHODS: This was a retrospective cohort study in China from July 2015 through June 2016. We used univariate and multivariate logistic regression models to test the associations among IPI, maternal age, and perinatal outcome (preterm delivery, term low birthweight, and small-for-gestational age)...
April 19, 2017: Birth
https://www.readbyqxmd.com/read/28416742/model-driven-optimization-of-antiangiogenics-cytotoxics-combination-application-to-breast-cancer-mice-treated-with-bevacizumab-paclitaxel-doublet-leads-to-reduced-tumor-growth-and-fewer-metastasis
#3
Severine Mollard, Joseph Ciccolini, Diane-Charlotte Imbs, Raouf El Cheikh, Dominique Barbolosi, Sebastien Benzekry
Bevacizumab is the first-in-class antiangiogenic drug and is almost always administrated in combination with cytotoxics. Reports have shown that bevacizumab could induce a transient phase of vascular normalization, thus ensuring a better drug delivery when cytotoxics administration is adjuvant. However, determining the best sequence remains challenging. We have developed a mathematical model describing the impact of antiangiogenics on tumor vasculature. A 3.4 days gap between bevacizumab and paclitaxel was first proposed by our model...
April 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28395550/the-impact-of-inter-pregnancy-interval-on-subsequent-risk-of-preterm-birth
#4
Vid Janša, Isaac Blickstein, Miha Lučovnik, Vesna Fabjan-Vodušek, Ivan Verdenik, Nataša Tul
OBJECTIVE: The aim of the study was to assess optimal time to conceive after previous delivery associated with smallest risk of preterm birth. METHODS: We selected all women (n = 2723) with their first and second singleton delivery between the years 2004 and 2012. Inter-pregnancy interval was defined as that between live birth and subsequent conception. We performed logistic regression analyses to assess the risk of preterm birth adjusted for maternal age and body mass index...
April 11, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28390435/inter-pregnancy-interval-and-pregnancy-outcomes-among-women-with-delayed-childbearing-protocol-for-a-systematic-review
#5
Mani Asgharpour, Sofia Villarreal, Laura Schummers, Jennifer Hutcheon, Dorothy Shaw, Wendy V Norman
BACKGROUND: Women in high resource nations are increasingly delaying childbearing until their thirties. Delayed childbearing poses challenges for the spacing of a woman's pregnancies. Inter-pregnancy intervals <12 months are associated with risk for adverse pregnancy outcome, yet increased maternal age at delivery is linked with increased risk. The optimal inter-pregnancy interval for older mothers is uncertain. This systematic review will aim to assess the relation between inter-pregnancy interval and perinatal and maternal health outcomes in women who delay childbearing to age 30 and older...
April 8, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28256583/gene-networks-activated-by-specific-patterns-of-action-potentials-in-dorsal-root-ganglia-neurons
#6
Philip R Lee, Jonathan E Cohen, Dumitru A Iacobas, Sanda Iacobas, R Douglas Fields
Gene regulatory networks underlie the long-term changes in cell specification, growth of synaptic connections, and adaptation that occur throughout neonatal and postnatal life. Here we show that the transcriptional response in neurons is exquisitely sensitive to the temporal nature of action potential firing patterns. Neurons were electrically stimulated with the same number of action potentials, but with different inter-burst intervals. We found that these subtle alterations in the timing of action potential firing differentially regulates hundreds of genes, across many functional categories, through the activation or repression of distinct transcriptional networks...
March 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28222563/afferent-electrical-stimulation-during-cycling-improves-spinal-processing-of-sensorimotor-function-after-incomplete-spinal-cord-injury
#7
Stefano Piazza, Diego Serrano-Muñoz, Julio Gómez-Soriano, Diego Torricelli, Antonio Segura-Fragosa, José Luis Pons, Julian Taylor
OBJECTIVE: Appropriate afferent feedback delivery during the execution of motor tasks is important for rehabilitation after incomplete spinal cord injury (iSCI). However, during leg-cycling therapy, the plantar afferent feedback is minimal. We hypothesize that the augmentation of sensory input by combining cycling with a locomotor-like stimulation of plantar cutaneous innervations (ES-cycling), might help to restore proper spinal processing of sensorimotor function. METHODS: Thirteen non-injured subjects and 10 subjects with iSCI performed 10 minutes of cycling and, on another session, of ES-cycling...
2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28180946/new-developments-and-directions-in-the-clinical-application-of-the-echinocandins
#8
REVIEW
C C Chang, M A Slavin, S C-A Chen
The echinocandins-caspofungin, anidulafungin and micafungin-are semi-synthetic cyclic hexapeptide antimicrobial agents with modified N-linked acyl lipid side chains which anchor the compounds to the phospholipid bilayer of the fungal cell membrane, thereby inhibiting synthesis of fungal cell wall glucan. Over the last 10 years, echinocandins have become the first-line antifungal treatment of candidaemia and other forms of invasive candidiasis (IC). Echinocandins are generally well tolerated, but their use is limited by their requirement for daily intravenous dosing, lack of oral formulation and limited spectrum...
February 8, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28166677/what-factors-are-related-to-recurrent-preterm-birth-among-underweight-women
#9
Anna I Girsen, Jonathan A Mayo, Matthew B Wallenstein, Jeffrey B Gould, Suzan L Carmichael, David K Stevenson, Deirdre J Lyell, Gary M Shaw
OBJECTIVE: Our objective was to identify factors associated with recurrent preterm birth among underweight women. METHODS: Maternally-linked hospital and birth certificate records of deliveries in California between 2007-2010 were used. Consecutive singleton pregnancies of women with underweight body mass index (BMI <18.5 kg/m(2)) in the first pregnancy were analyzed. Pregnancies were categorized based on outcome of the first and second birth as: term-term; term-preterm; preterm-term and preterm-preterm...
February 6, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28033542/panic-attack-history-and-smoking-topography
#10
Samantha G Farris, Lily A Brown, Renee D Goodwin, Michael J Zvolensky
BACKGROUND: Little is known about panic attacks and puffing topography, a behavioral index of the value of smoking reinforcement. This study examined smoking style during the course of smoking of a single cigarette among adult daily smokers with and without a history of panic attacks. METHOD: Participants (n=124, Mage=43.9, SD=9.7; 44.4% female) were non-treatment seeking daily smokers. Lifetime panic attack history was assessed via diagnostic assessment; 28.2% (n=35) of the sample had a panic attack history...
February 1, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28032895/analysis-of-components-of-variance-determining-probability-of-setup-errors-in-cbct-guided-stereotactic-radiotherapy-of-lung-tumors
#11
Johan P Cuijpers, Max Dahele, Marianne Jonker, Bianca Kraan, Suresh Senan, Ben Slotman, Wilko Far Verbakel
PURPOSE: Online tumor matching for SABR lung setup requires margins for inaccuracies due to intra-fraction variability of breathing-averaged tumor position (BATP) and CBCT image guidance. We studied intra-fraction variability during SABR delivery using VMAT, corrected these for measurement inaccuracies, and quantified the CBCT image-guidance uncertainties. MATERIALS AND METHODS: For 193 fractions in 38 patients positioned without immobilization devices, CBCT scans were acquired before and after 2 arcs of a RapidArc treatment...
February 2017: Medical Physics
https://www.readbyqxmd.com/read/28029632/smartban-with-periodic-monitoring-traffic-a-performance-study-on-low-delay-and-high-energy-efficiency
#12
Lihua Ruan, M Pubuduni Imali Dias, Elaine Wong
The Smart Body Area Network (SmartBAN) is a recently proposed system for wireless body area networks (WBANs). Compared to conventional WBANs, it is designed to support lower system complexity and ultra-low power consumption. In a SmartBAN, the sensors' access is scheduled upon receiving a beacon on the data channel at the beginning of each working cycle, termed inter-beacon interval (IBI). As network performance including delay and energy consumption is highly dependent on the length of IBI, we present, in this paper, an Optimal IBI frame for SmartBAN...
December 20, 2016: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28029609/seeking-control-in-the-midst-of-uncertainty-women-s-experiences-of-choosing-mode-of-birth-after-caesarean
#13
Sarah Munro, Patricia Janssen, Kitty Corbett, Elizabeth Wilcox, Nick Bansback, Jude Kornelsen
PROBLEM: Clinical practice guidelines indicate that over 80% of women with a previous caesarean should be offered a planned vaginal birth after caesarean (VBAC), however only one third of eligible women choose to plan a VBAC. To support informed choices for birth after caesarean, it is necessary to understand the factors that influence women's decision-making. AIM: The goal of this study was to explore attitudes towards and experiences with decision-making for mode of delivery after caesarean from the perspectives of Canadian women...
October 28, 2016: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/27903080/inter-pregnancy-interval-and-adverse-outcomes-evidence-for-an-additional-risk-in-health-disparate-populations
#14
Shyama Appareddy, Jason Pryor, Beth Bailey
OBJECTIVE: Short interpregnancy interval (IPI), <18 months between pregnancies, is a potential cause of adverse delivery and birth outcomes, and may be a particular issue among those with other risks. Our goal was to examine IPI and delivery/infant complications in Tennessee. METHODS: Birth certificate/vital records data included 101,912 women with a previous delivery. IPI groups (<6, 6-12, 12-18, 18-60 months) were compared on outcomes. RESULTS: Thirty-nine percent of the deliveries had IPI <18 months, 9% were <6 months, rates 11% and 27% higher than nationally...
December 1, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27874979/risk-factors-for-recurrence-of-hypertensive-disorders-of-pregnancy-a-population-based-cohort-study
#15
Cathrine Ebbing, Svein Rasmussen, Rolv Skjaerven, Lorentz M Irgens
INTRODUCTION: Hypertensive disorders of pregnancy (HDP) tend to recur from one pregnancy to the next. The aims of the study were to assess the recurrence risk according to type of HDP defined by gestational age at birth and to examine whether recurrence is associated with the following additional risk factors for HDP: maternal age, smoking, inter-delivery interval, diabetes, body mass index, and fetal growth restriction, and to assess temporal trends in these associations. MATERIAL AND METHODS: All women with two singleton births in the Medical Birth Registry of Norway 1967-2012 (n = 742 980) were included in this population-based cohort study...
February 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/27819254/full-beam-performances-of-a-pet-detector-with-synchrotron-therapeutic-proton-beams
#16
M A Piliero, F Pennazio, M G Bisogni, N Camarlinghi, P G Cerello, A Del Guerra, V Ferrero, E Fiorina, G Giraudo, M Morrocchi, C Peroni, G Pirrone, G Sportelli, R Wheadon
Treatment quality assessment is a crucial feature for both present and next-generation ion therapy facilities. Several approaches are being explored, based on prompt radiation emission or on PET signals by [Formula: see text]-decaying isotopes generated by beam interactions with the body. In-beam PET monitoring at synchrotron-based ion therapy facilities has already been performed, either based on inter-spill data only, to avoid the influence of the prompt radiation, or including both in-spill and inter-spill data...
December 7, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27799176/i-v-paracetamol-as-an-adjunct-to-patient-controlled-epidural-analgesia-with-levobupivacaine-and-fentanyl-in-labour-a-randomized-controlled-study
#17
K Gupta, S Mitra, S Kazal, R Saroa, V Ahuja, P Goel
BACKGROUND: Use of i.v. paracetamol for postoperative pain is well documented, but it is unclear if it can reduce the consumption of opioids during patient-controlled epidural analgesia (PCEA) in labouring parturients. METHODS: In this randomized, double-blind, placebo-controlled clinical trial conducted in a tertiary care hospital, (80)parturients were randomly assigned to two groups of 40 each, to receive either 1000 mg (100 ml) i.v. paracetamol or 100 ml normal saline as placebo, 30 min before the procedure...
November 2016: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/27780708/risk-factors-for-complete-uterine-rupture
#18
Iqbal Al-Zirqi, Anne Kjersti Daltveit, Lisa Forsén, Babill Stray-Pedersen, Siri Vangen
BACKGROUND: Complete uterine rupture is a rare peripartum complication associated with a catastrophic outcome. Because of its rarity, knowledge about its risk factors is not very accurate. Most previous studies were small and over a limited time interval. Moreover, international diagnostic coding was used in most studies. These codes are not able to differentiate between the catastrophic complete type and less catastrophic partial type. Complete uterine rupture is expected to increase as the rate of cesarean delivery increases...
October 22, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27613914/the-influence-of-a-mouthpiece-based-topography-measurement-device-on-electronic-cigarette-user-s-plasma-nicotine-concentration-heart-rate-and-subjective-effects-under-directed-and-ad-libitum-use-conditions
#19
Tory R Spindle, Marzena M Hiler, Alison B Breland, Nareg V Karaoghlanian, Alan L Shihadeh, Thomas Eissenberg
Introduction: Electronic cigarettes e-cigarettes aerosolize a liquid solution often containing nicotine. e-cigarette nicotine delivery may be influenced by user puffing behaviors ("puff topography"). E-cigarette puff topography can be recorded using mouthpiece-based computerized systems. The present study sought to examine the extent to which these systems influence e-cigarette nicotine delivery and other e-cigarette associated acute effects under ad libitum use conditions. Methods: Plasma nicotine concentration, heart rate, and subjective effects were assessed in 29 experienced e-cigarette users using their preferred e-cigarette battery and liquid (≥12mg/mL nicotine) in two sessions differing only by the presence of a mouthpiece-based device...
April 1, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/27601018/modifiable-risk-factors-for-gestational-diabetes-recurrence
#20
Naama Schwartz, Manfred S Green, Enav Yefet, Zohar Nachum
The literature on risk factors for gestational diabetes mellitus recurrence is inconsistent and sometimes contradictory. The importance of inter-pregnancy interval and parity, remains unclear. We aimed to explore controversial risk factors for gestational diabetes mellitus recurrence, especially the modifiable ones, and to develop a prediction model in a cohort of women with gestational diabetes mellitus. A retrospective, population-based, cross-sectional cohort study was performed. The study included 788 women with gestational diabetes mellitus that delivered between 1991-2012 and had consecutive deliveries at a university affiliated hospital in Israel...
December 2016: Endocrine
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