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https://www.readbyqxmd.com/read/28632794/migrants-healthy-worker-effect-and-mortality-trends-in-the-gulf-cooperation-council-countries
#1
Karima Chaabna, Sohaila Cheema, Ravinder Mamtani
The Gulf Cooperation Council (GCC) countries namely, Bahrain, Kuwait, Oman, Qatar, United Arab Emirates (UAE), and Saudi Arabia, have experienced unique demographic changes. The major population growth contributor in these countries is young migrants, which has led to a shift in the population age pyramid. Migrants constitute the vast proportion of GCC countries' population reaching >80% in Qatar and UAE. Using Global Burden of Disease Study 2015 (GBD 2015) and United Nations data, for the GCC countries, we assessed the association between age-standardized mortality and population size trends with linear and polynomial regressions...
2017: PloS One
https://www.readbyqxmd.com/read/28626185/miliary-tuberculosis-that-developed-after-intravesical-bacillus-calmette-guerin-therapy
#2
Kyohei Kaburaki, Keishi Sugino, Muneyuki Sekiya, Yujiro Takai, Kazutoshi Shibuya, Sakae Homma
As a treatment for superficial transitional cell carcinoma, Bacillus Calmette-Guerin (BCG) intravesical instillation can rarely cause unpredictable systemic side effects. We describe a patient admitted due to continuous pyrexia and general fatigue. He was previously treated with intravesical BCG. Laboratory data indicated a hepatic disorder, and chest computed tomography revealed extensive bilateral miliary nodules. Transbronchial lung biopsy specimens showed several small noncaseating granulomas. The diagnosis was unsolved on the basis of acid fast staining, polymerase chain reaction and microbiological cultures, so we considered the possibility of BCG side effect-induced granuloma...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28591334/-evaluation-of-implementation-of-the-protocol-for-managing-tuberculosis-human-immunodeficiency-virus-coinfection-in-specialized-care-services-in-cear%C3%A3-state
#3
Silvia Helena Bastos de Paula, Telma Alves Martins, Sheila Maria Santiago Borges, Christiana Maria de Oliveira Nogueira, Valderina Ramos Freire
Objectives: Identify barriers and strategies for implementation of the protocol for managing tuberculosis/ human immunodeficiency virus (TB/HIV) coinfection in specialized care services in Ceará state, through evaluation research. Methods: The study followed iPIER methodology, a new initiative to help improve the implementation of health programs through the use of research that is conducted as a part of the implementation process. Data were collected on the structure and processes of 22 services and barriers were explored in four focus groups with 28 participants, from the standpoint of the health team, administrators, and users...
May 25, 2017: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28579706/hepatotoxicity-due-to-antituberculosis-therapy-among-paediatric-patients-seen-at-the-university-of-ilorin-teaching-hospital-north-central-nigeria
#4
Gobir Aishatu, Ibraheem Rasheedah, Johnson Wahab, Muhammed Sheni, Oladele Damilola, Ojuola Adeniyi
BACKGROUND: The liver is vulnerable to injury from the first line anti-tuberculosis drugs. This may result in mortality, long term morbidity and reduced compliance to therapy. Nigeria recently introduced fixed drug combinations in the treatment of children amid concerns of hepatotoxicity. A 6-year-old boy was treated in our unit had fulminant hepatic failure two weeks after completing his anti-tuberculosis therapy. This prompted the unit to investigate hepatotoxicity due to anti-tuberculosis therapy among children...
March 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/28571549/nanoemulsion-based-transdermal-drug-delivery-system-for-the-treatment-of-tuberculosis
#5
Mohammad Wais, Mohd Aqil, Ashish Kumar Sharma, Jaya Agnihotri
BACKGROUND: The nanoemulsion based carriers are the most suitable delivery systems for poorly soluble drugs to improve the solubility of drugs, permeation of drugs and ultimately increase bioavailability by transdermal therapeutic system. The nanoemulsion for poorly soluble drugs is the excellent and offered several advantages over others carriers. METHODS: For the nanoemulsions formulation they have to deliver the energetic element at the specific organ with nominal uneasiness...
June 1, 2017: Recent Patents on Anti-infective Drug Discovery
https://www.readbyqxmd.com/read/28567336/management-of-hepatic-granulomatous-tuberculosis-after-bcg-therapy-for-bladder-cancer
#6
Mohsen Ayati, Mohammad Reza Nowroozi, Afshin Mortazavi, Solmaz Ohadian Moghadam, Hossein Ghorani
BCG therapy is used as a treatment in bladder cancer. Intravesical administration of Bacillus Calmette-Guérin is used as a treatment method in superficial bladder cancer. While it is commonly effective, some serious side effects may occur. We hereby report a 65-year-old man who developed granulomatous hepatitis as a complication following BCG therapy. He was treated successfully with antitubercular therapy and prednisolone.
July 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28559523/the-first-report-of-two-cases-of-fatal-liver-injury-due-to-anti-tuberculosis-drugs-in-the-presence-of-alpha-1-antitrypsin-deficiency
#7
Shahram Habibzadeh, Jafar Mohammad Shahi, Hassan Ghobadi, Nasrollah Maleki
Tuberculosis (TB) is a major global health problem. Awareness of liver injury due to anti-TB therapy is vital because fulminant hepatic failure is a devastating and often fatal condition without liver transplantation. Here, we report for the first time, two patients of fatal liver injury due to anti-TB drugs in the presence of alpha-1 antitrypsin deficiency. Based on the triad of rapid loss in hepatocyte function, the onset of hepatic encephalopathy, and absence of a prior history of liver disease, the diagnosis of acute liver failure was established...
April 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28559516/cholecalciferol-for-prophylaxis-against-antituberculosis-therapy-induced-liver-disorders-among-na%C3%A3-ve-patients-with-pulmonary-tuberculosis-a-randomized-comparative-study
#8
Ahmad Farooq Alsayed Hasanain, Ali Abdel-Azeem Hasan Zayed, Reem Ezzat Mahdy, Amany Mohamed Adawi Nafee
BACKGROUND: Patients in countries endemic for chronic viral hepatitis are more vulnerable to antituberculosis therapy-induced liver disorders (ATT-LDs). The aim of this study was to explore the role of cholecalciferol in prophylaxis against ATT-LD among patients with pulmonary tuberculosis (TB) receiving ATT. MATERIAL AND METHODS: We conducted a hospital-based, prospective, randomized, comparative study which included 300 consecutive, naïve patients with pulmonary TB eligible for ATT...
April 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28557994/the-societal-cost-of-heroin-use-disorder-in-the-united-states
#9
Ruixuan Jiang, Inyoung Lee, Todd A Lee, A Simon Pickard
OBJECTIVE: Heroin use in the United States has reached epidemic proportions. The objective of this paper is to estimate the annual societal cost of heroin use disorder in the United States in 2015 US dollars. METHODS: An analytic model was created that included incarceration and crime; treatment for heroin use disorder; chronic infectious diseases (HIV, Hepatitis B, Hepatitis C, and Tuberculosis) and their treatments; treatment of neonatal abstinence syndrome; lost productivity; and death by heroin overdose...
2017: PloS One
https://www.readbyqxmd.com/read/28553027/a-ten-year-audit-of-maternal-mortality-millennium-development-still-a-distant-goal
#10
Anshuja Singla, Shalini Rajaram, Sumita Mehta, Gita Radhakrishnan
OBJECTIVE: To assess various causes of maternal mortality over a ten year period. DESIGN: Retrospective audit of hospital case records. SETTING: Tertiary care hospital. POPULATION: Pregnant women who expired in the premises of GTB Hospital. MATERIALS AND METHODS: A retrospective audit of case records of maternal deaths was conducted for a ten year period (January 2005 to December 2014). RESULTS: There were a total of 647 maternal deaths out of 1,16,641 live births...
April 2017: Indian Journal of Community Medicine
https://www.readbyqxmd.com/read/28549451/clinical-and-laboratory-evaluation-of-new-immigrant-and-refugee-children-arriving-in-greece
#11
Ioanna D Pavlopoulou, Marsela Tanaka, Stavroula Dikalioti, Evangelia Samoli, Pavlos Nisianakis, Olga D Boleti, Konstantinos Tsoumakas
BACKGROUND: Migrant children are a population at risk for various health problems. Despite the increased inflow of migrants in Greece, data regarding their health assessment are lacking. This study aims to describe the clinical and certain laboratory characteristics and identify possible associations in a group of new immigrant (I) and refugee (R) children, arriving in Athens, Greece. METHODS: A prospective, cross- sectional study was performed in a migrant outpatient clinic of a tertiary Children's hospital...
May 26, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28539734/honey-and-health-a-review-of-recent-clinical-research
#12
REVIEW
Saeed Samarghandian, Tahereh Farkhondeh, Fariborz Samini
Honey is one of the most appreciated and valued natural products introduced to humankind since ancient times. Honey is used not only as a nutritional product but also in health described in traditional medicine and as an alternative treatment for clinical conditions ranging from wound healing to cancer treatment. The aim of this review is to emphasize the ability of honey and its multitude in medicinal aspects. Traditionally, honey is used in the treatment of eye diseases, bronchial asthma, throat infections, tuberculosis, thirst, hiccups, fatigue, dizziness, hepatitis, constipation, worm infestation, piles, eczema, healing of ulcers, and wounds and used as a nutritious supplement...
April 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28535545/portuguese-recommendations-for-the-use-of-methotrexate-in-rheumatic-diseases-2016-update
#13
Ana Catarina Duarte, Daniela Santos-Faria, Maria João Gonçalves, Alexandre Sepriano, Ana Filipa Mourão, Cátia Duarte, Joana Sousa Neves, Ana Filipa Águeda, Pedro Ávila Ribeiro, Alexandra Daniel, Adriano Neto, Ana Cordeiro, Ana Rodrigues, Anabela Barcelos, Cândida Silva, Cristina Ponte, Elsa Vieira-Sousa, Filipa Teixeira, Filipa Oliveira-Ramos, Filipe Araújo, Filipe Barcelos, Helena Canhão, Helena Santos, João Ramos, Joaquim Pereira, José Costa, José António Melo Gomes, Luís Cunha-Miranda, Lúcia Costa, Marcos Cerqueira, Margarida Cruz, Maria José Santos, Miguel Bernardes, Paula Oliveira, Pedro Abreu, Ricardo Figueira, Rita Barros, Sandra Falcão, Patrícia Pinto, Sofia Pimenta, Susana Capela, Vitor Teixeira, João Eurico Fonseca
BACKGROUND: Methotrexate (MTX) is the first-line drug in the treatment of rheumatoid arthritis (RA) and the most commonly prescribed disease modifying anti-rheumatic drug. Moreover, it is also used as an adjuvant drug in patients under biologic therapies, enhancing the efficacy of biologic agents. OBJECTIVES: To review the literature and update the Portuguese recommendations for the use of MTX in rheumatic diseases first published in 2009. METHODS: The first Portuguese guidelines for the use of MTX in rheumatic diseases were published in 2009 and were integrated in the multinational 3E Initiative (Evidence Expertise Exchange) project...
May 9, 2017: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/28500120/the-clinical-conundrum-of-diagnosing-and-treating-systemic-sarcoidosis-in-a-high-tb-burden-area
#14
Krishnadas Thulasidoss, Lavanya Asokan, Piyush Chandra, Pravinkumar Rejliwal
A 53-year-old woman from Southern India presented with weight loss, anorexia, fever and asthenia. Whole body positron emission tomography/computed tomography (PET-CT) showed fluorodeoxyglucose-avid mediastinal and abdominal lymphadenopathy with hepatic, splenic, parotid and lacrimal glandular inflammations. Endoscopic ultrasound-guided fine needle aspiration of subcarinal lymph node showed non-caseating granulomas. Initial serum ACE level was elevated but with normal calcium. Despite the suspicion of sarcoidosis, a trial of antituberculosis therapy was started empirically due to similar presentations of disseminated tuberculosis (TB) in this high endemic area...
May 12, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28490478/mixed-cryoglobulinemia-a-diagnostic-and-therapeutic-challenge
#15
Maria Túlio, Liliana Carvalho, Tiago Bana E Costa, Cristina Chagas
Mixed cryoglobulinemia is frequently secondary to hepatitis C virus infection. Diagnosis and therapeutic management are challenging, depending on the spectrum and severity of manifestations, as well as on the presence of comorbidities. We describe a case of a 79-year-old woman with a non-cirrhotic hepatitis C virus infection presenting with weakness, arthralgias, purpuric rash with left leg ulcerative lesions, bilateral peripheral sensorimotor polyneuropathy, renal impairment and cardiac failure. The investigation was compatible with a severe type II mixed cryoglobulinemia with multisystemic involvement, including a low-grade B cell lymphoma and concomitant intestinal tuberculosis...
May 10, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28465448/elevated-interferon-%C3%AE-induced-protein-10-and-its-receptor-cxcr3-impair-nk-cell-function-during-hiv-infection
#16
Zhuo Wang, Tong Wu, Meichen Ma, Zining Zhang, Yajing Fu, Jing Liu, Junjie Xu, Haibo Ding, Xiaoxu Han, Zhenxing Chu, Yuntao Wu, Hong Shang, Yongjun Jiang
As the first line of defense in the human immune system, NK cells play essential roles in prevention of tumorigenesis and viral infection. It is known that NK cells have impaired function in HIV infection; however, it remains unclear why this occurs. IP-10 is a chemokine and inflammatory factor that is associated with such diseases as tuberculosis, hepatitis B virus, and pancreatic cancer. The aim of this study was to evaluate IP-10 levels and CXCR3 expression in NK cells that were affected by HIV and to elucidate whether NK cell function could be affected by IP-10...
May 2, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28463853/the-role-of-activists-in-access-to-hiv-and-tuberculosis-treatment-and-prevention
#17
Nathan Geffen
PURPOSE OF REVIEW: We describe the role of activism in improving access to quality HIV treatment. RECENT FINDINGS: In many countries, AIDS activists have campaigned for improved access to HIV treatment and prevention interventions. Studying medicine, epidemiology and law, and developing expertise in these fields, has been crucial to the success of these campaigns. Also important has been the building of alliances by activists with clinicians, nurses, scientists, and public health policy experts, persuading them of the importance of these campaigns...
July 2017: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/28451090/a-rare-complication-of-pulmonary-tuberculosis-pulmonary-venous-thrombosis-with-atrial-extension
#18
Onkar Balasaheb Auti, Ranganath R, Murali Mohan Bv, Vimal Raj
Pulmonary tuberculosis (TB) is serious public health problem in India and worldwide. The mortality rate in pulmonary TB is high in those with advanced disease and in presence of complications. It presents with wide variety of complications of which haematological complications are rare. Many cases were reported pulmonary TB associated with deep venous thrombosis, hepatic and portal venous thrombosis, central retinal venous thrombosis and sagittal sinus thrombosis in TB meningitis. We report a rare case of pulmonary TB with pulmonary venous thrombosis and atrial extension...
2017: Journal of Cardiovascular and Thoracic Research
https://www.readbyqxmd.com/read/28451026/national-strategy-for-the-integration-of-pharmacovigilance-in-the-moroccan-tb-control-program
#19
Driss Soussi Tanani, Samira Serragui, Sanae Hammi, Latifa Ait Moussa, Abdelmajid Soulaymani, Rachida Soulaymani, Yahia Cherrah
The objective of this work is to demonstrate the interest of integration of pharmacovigilance in Moroccan Tuberculosis Control Program (MTCP). The integration of pharmacovigilance in MTCP was conducted in October 2012with the Global Fund support. We compared the reports notified before and after this integration (period 1: January 2010-October2012; period 2: October 2012-December 2013). The detection of signals was based on the Information Component available inVigiMine. We used the SPSS version 10.0 and Med Calc version 7...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28446740/biological-risk-among-agriculture-and-construction-workers-in-molise-region-central-italy
#20
Manuela Tamburro, Vincenza Anzelmo, Paolo Bianco, Michela Lucia Sammarco, Francesco Salierno, Giancarlo Ripabelli
BACKGROUND: Biological risk is a significant issue in workplaces due to continuous modification of work organization and condition. OBJECTIVES: In this pilot study, perception and knowledge of biological risk, as well as adoption of prevention measures were evaluated among construction and agriculture workers. METHODS: A structured questionnaire was administered to workers to collect socio-demographic and employment information, in addition to data on risk perception and knowledge, and adoption of preventive measures, including those related to work activities...
April 21, 2017: La Medicina del Lavoro
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