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Ischemic heat disease

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https://www.readbyqxmd.com/read/28442482/a-bag3-coding-variant-in-mice-determines-susceptibility-to-ischemic-limb-muscle-myopathy-by-directing-autophagy
#1
Joseph M McClung, Timothy J McCord, Terence E Ryan, Cameron A Schmidt, Thomas D Green, Kevin W Southerland, Jessica L Reinardy, Sarah B Mueller, Talaignair N Venkatraman, Christopher D Lascola, Sehoon Keum, Douglas A Marchuk, Espen E Spangenburg, Ayotunde O Dokun, Brian H Annex, Christopher D Kontos
Background -Critical limb ischemia (CLI) is a manifestation of peripheral artery disease (PAD) that carries significant mortality and morbidity risk in humans, although its genetic determinants remain largely unknown. We previously discovered two overlapping quantitative trait loci (QTL) in mice, Lsq-1 and Civq-1, that affected limb muscle survival and stroke volume following femoral artery or middle cerebral artery ligation, respectively. Here we report that a Bag3 variant (Ile81Met) segregates with tissue protection from hindlimb ischemia (HLI)...
April 25, 2017: Circulation
https://www.readbyqxmd.com/read/28409870/comparative-efficacy-and-safety-of-anti-platelet-agents-in-cerebral-ischemic-disease-a-network-meta-analysis
#2
Da Wa, Pa Zhu, Ziwen Long
We performed this network meta-analysis (NMA) to enhance the corresponding evidence of the relative efficacy and safety of different anti-platelet agents in cerebral ischemic disease. PubMed and EMBASE were searched systematically for relevant studies. Outcomes were compared using odds ratios (ORs) and 95% credible intervals (CrI). Each agent was ranked according to the value of surface under the cumulative ranking curve (SUCRA). Publication bias was evaluated by funnel plots while consistency between direct and indirect comparison was analyzed by node splitting and heat plots...
April 14, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28337294/hypoxic-preconditioning-of-human-cardiosphere-derived-cell-sheets-enhances-cellular-functions-via-activation-of-the-pi3k-akt-mtor-hif-1%C3%AE-pathway
#3
Yuya Tanaka, Tohru Hosoyama, Akihito Mikamo, Hiroshi Kurazumi, Arata Nishimoto, Koji Ueno, Bungo Shirasawa, Kimikazu Hamano
Cell sheet technology is a promising therapeutic strategy for the treatment of ischemic diseases such as myocardial infarction. We recently developed a novel protocol, termed "hypoxic preconditioning," capable of augmenting the therapeutic efficacy of cell sheets. Following this protocol, the pro-angiogenic and anti-fibrotic activity of cell sheets were enhanced by brief incubation of cell sheets under hypoxic culture conditions. However, the precise molecular mechanism underlying the hypoxic preconditioning of cell sheets is unclear...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28250763/molecular-chaperones-and-hypoxic-ischemic-encephalopathy
#4
REVIEW
Cong Hua, Wei-Na Ju, Hang Jin, Xin Sun, Gang Zhao
Hypoxic-ischemic encephalopathy (HIE) is a disease that occurs when the brain is subjected to hypoxia, resulting in neuronal death and neurological deficits, with a poor prognosis. The mechanisms underlying hypoxic-ischemic brain injury include excitatory amino acid release, cellular proteolysis, reactive oxygen species generation, nitric oxide synthesis, and inflammation. The molecular and cellular changes in HIE include protein misfolding, aggregation, and destruction of organelles. The apoptotic pathways activated by ischemia and hypoxia include the mitochondrial pathway, the extrinsic Fas receptor pathway, and the endoplasmic reticulum stress-induced pathway...
January 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28238433/impact-of-temperature-variation-on-mortality-an-observational-study-from-12-counties-across-hubei-province-in-china
#5
Yunquan Zhang, Chuanhua Yu, Junzhe Bao, Xudong Li
BACKGROUND: Compared with cold- and heat-related health impacts, the evidence was very limited in assessing the mortality effects of temperature variation (TV) accounting for both intra-day and inter-day changes in temperature. OBJECTIVE: We used a newly proposed composite indicator of intra-day and inter-day TV and evaluated TV-mortality associations in Hubei, China at the provincial level. METHODS: Daily mortality and meteorological data during 2009-2012 were obtained from 12 urban and rural counties across Hubei Province in China...
February 23, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28237309/impact-of-climate-change-on-heat-related-mortality-in-jiangsu-province-china
#6
Kai Chen, Radley M Horton, Daniel A Bader, Corey Lesk, Leiwen Jiang, Bryan Jones, Lian Zhou, Xiaodong Chen, Jun Bi, Patrick L Kinney
A warming climate is anticipated to increase the future heat-related total mortality in urban areas. However, little evidence has been reported for cause-specific mortality or nonurban areas. Here we assessed the impact of climate change on heat-related total and cause-specific mortality in both urban and rural counties of Jiangsu Province, China, in the next five decades. To address the potential uncertainty in projecting future heat-related mortality, we applied localized urban- and nonurban-specific exposure response functions, six population projections including a no population change scenario and five Shared Socioeconomic Pathways (SSPs), and 42 temperature projections from 21 global-scale general circulation models and two Representative Concentration Pathways (RCPs)...
May 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28191532/the-role-of-heat-shock-proteins-in-kidney-disease
#7
REVIEW
Shobhana Nayak Rao
Heat Shock Proteins (HSP) belong to the family of intracellular proteins that are constitutively expressed and are upregulated by various stressors including heat, oxidative and chemical stress. HSP helps in reparative processes, including the refolding of damaged proteins and the removal of irreparably damaged proteins that would initiate cellular death or apoptosis. A growing body of evidence has expanded the role of HSP and defined their role in diseases such as neurodegenerative disorders, cancer, ischemic heart disease and kidney diseases...
September 1, 2016: Journal of Translational Internal Medicine
https://www.readbyqxmd.com/read/28138311/specific-networks-of-plasma-acute-phase-reactants-are-associated-with-the-severity-of-chronic-obstructive-pulmonary-disease-a-case-control-study
#8
Elena Arellano-Orden, Carmen Calero-Acuña, Juan Antonio Cordero, María Abad-Arranz, Verónica Sánchez-López, Eduardo Márquez-Martín, Francisco Ortega-Ruiz, José Luis López-Campos
Objectives. A detailed understanding of the intricate relationships between different acute phase reactants (APRs) in chronic obstructive pulmonary disease (COPD) can shed new light on its clinical course. In this case-control study, we sought to identify the interaction networks of a number of plasma APRs in COPD, with a special focus on their association with disease severity. Methods. COPD cases and healthy smoking controls (3:1 ratio) were recruited in our outpatient pulmonary clinic. Cardiopulmonary exercise testing was used to rule out the presence of ischemic heart disease...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28097803/regulation-of-mrna-following-brain-ischemia-and-reperfusion
#9
REVIEW
Donald J DeGracia
There is growing appreciation that mRNA regulation plays important roles in disease and injury. mRNA regulation and ribonomics occur in brain ischemia and reperfusion (I/R) following stroke and cardiac arrest and resuscitation. It was recognized over 40 years ago that translation arrest (TA) accompanies brain I/R and is now recognized as part of the intrinsic stress responses triggered in neurons. However, neuron death correlates to a prolonged TA in cells fated to undergo delayed neuronal death (DND). Dysfunction of mRNA regulatory processes in cells fated to DND prevents them from translating stress-induced mRNAs such as heat shock proteins...
January 17, 2017: Wiley Interdisciplinary Reviews. RNA
https://www.readbyqxmd.com/read/28052764/tat-hsp22-inhibits-oxidative-stress-induced-hippocampal-neuronal-cell-death-by-regulation-of-the-mitochondrial-pathway
#10
Hyo Sang Jo, Dae Won Kim, Min Jea Shin, Su Bin Cho, Jung Hwan Park, Chi Hern Lee, Eun Ji Yeo, Yeon Joo Choi, Hyeon Ji Yeo, Eun Jeong Sohn, Ora Son, Sung-Woo Cho, Duk-Soo Kim, Yeon Hee Yu, Keun Wook Lee, Jinseu Park, Won Sik Eum, Soo Young Choi
Oxidative stress plays an important role in the progression of various neuronal diseases including ischemia. Heat shock protein 22 (HSP22) is known to protect cells against oxidative stress. However, the protective effects and mechanisms of HSP22 in hippocampal neuronal cells under oxidative stress remain unknown. In this study, we determined whether HSP22 protects against hydrogen peroxide (H2O2)-induced oxidative stress in HT-22 using Tat-HSP22 fusion protein. We found that Tat-HSP22 transduced into HT-22 cells and that H2O2-induced cell death, oxidative stress, and DNA damage were significantly reduced by Tat-HSP22...
January 4, 2017: Molecular Brain
https://www.readbyqxmd.com/read/27903363/-acute-effect-of-daily-mean-temperature-on-ischemic-heart-disease-mortality-a-multivariable-meta-analysis-from-12-counties-across-hubei-province-china
#11
Y Q Zhang, C H Yu, J Z Bao
Objective: To evaluate the acute effects of daily mean temperature on ischemic heart disease (IHD) mortality in 12 counties across Hubei Province, China. Methods: We obtained the daily IHD mortality data and meteorological data of the 12 counties for 2009-2012. The distributed lag nonlinear model (DLNM) was used to estimate the community-specific association between mean temperature and IHD mortality. A multivariate meta-analysis was then applied to pool the community-specific relationship between temperature and IHD mortality, and the effects of cold and heat on mortality risk...
November 6, 2016: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/27754056/os-15-04-mineralocorticoid-receptor-antagonists-target-endogenous-repressor-of-hypertrophy
#12
Anastasia Mihailidou, Anthony Ashton
OBJECTIVE: Myocardial infarction (MI) continues to be a major burden of disease, despite rapid reperfusion interventions. Reperfusion of ischemic hearts (reperfusion injury) induces free radical generation, activation of early stress responses and apoptosis, which contributes to ventricular remodeling and dysfunction, which may lead to developing heart failure. Mineralocorticoid receptor (MR) antagonists have been shown clinically to reduce blood pressure, particularly in resistant hypertension, and substantially increase survival in heart failure...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27642976/os-15-04-mineralocorticoid-receptor-antagonists-target-endogenous-repressor-of-hypertrophy
#13
Anastasia Mihailidou, Anthony Ashton
OBJECTIVE: Myocardial infarction (MI) continues to be a major burden of disease, despite rapid reperfusion interventions. Reperfusion of ischemic hearts (reperfusion injury) induces free radical generation, activation of early stress responses and apoptosis, which contributes to ventricular remodeling and dysfunction, which may lead to developing heart failure. Mineralocorticoid receptor (MR) antagonists have been shown clinically to reduce blood pressure, particularly in resistant hypertension, and substantially increase survival in heart failure...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27572090/plasma-heme-oxygenase-1-is-decreased-in-peripheral-artery-disease-patients
#14
Salvatore Santo Signorelli, Guido Li Volsi, Valerio Fiore, Marco Mangiafico, Ignazio Barbagallo, Rosalba Parenti, Manfredi Rizzo, Giovanni Li Volti
Peripheral artery disease (PAD) is a common manifestation of atherosclerosis. A number of emerging risk factors, including oxidative stress biomarkers, free radicals and heat shock proteins, may add to the established risk factors for cardiovascular disease (CVD). The present study assessed surrogate markers of oxidative stress, including total reduced glutathione (GSH), lipid hydroperoxides (LOOH), isoprostanes, heme oxygenase‑1 (HO‑1) and metabolic biomarkers, such as adiponectin and lactate, in PAD patients (n=27)...
October 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27508642/-op-2d-07-the-effects-of-alpha-1-adrenoceptor-blockade-by-doxazosin-or-ace-inhibition-by-ramipril-on-endothelial-function-in-primary-hypertension-the-dora-study
#15
A Jekell, M Kalani, T Kahan
OBJECTIVE: To study whether reducing noradrenergic sympathetic vascular tone by doxazosin or blocking the renin-angiotensin-aldosterone system by ramipril will alter endothelial function in patients with uncomplicated hypertension. DESIGN AND METHOD: Mild-to-moderate hypertensive patients (age 54 ± 12 years, 34% women, blood pressure (BP) 148 ± 11/88 ± 9 mmHg) were randomized double-blind to ramipril (10 mg od, n = 33) or doxazosin (8 mg od, n = 28) for 12 weeks...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27381220/effects-of-protein-transduction-domain-ptd-selection-and-position-for-improved-intracellular-delivery-of-ptd-hsp27-fusion-protein-formulations
#16
Qurrat Ul Ain, Jong Hwan Lee, Young Sun Woo, Yong-Hee Kim
Protein drugs have attracted considerable attention as therapeutic agents due to their diversity and biocompatibility. However, hydrophilic proteins possess difficulty in penetrating lipophilic cell membrane. Although protein transduction domains (PTDs) have shown effectiveness in protein delivery, the importance of selection and position of PTDs in recombinant protein vector constructs has not been investigated. This study intends to investigate the significance of PTD selection and position for therapeutic protein delivery...
September 2016: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/27318648/temporal-profiles-of-stress-protein-inductions-after-focal-transient-ischemia-in-mice-brain
#17
Qian Li, Yumiko Nakano, Jingwei Shang, Yasuyuki Ohta, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Toru Yamashita, Koji Abe
BACKGROUND: Stress proteins have been found to play important protective roles against ischemic brain injury under hypoxic, oxidative, heat shock, and proteasome stresses. METHODS: In the present study, we investigated the temporal profiles of the major stress proteins including hypoxia-inducible factor-1α (HIF-1α), glutathione (GSH), heat shock protein 72 (HSP72), constitutive heat shock cognate protein 73 (HSC73), and ubiquitin after 45 minutes of transient middle cerebral artery occlusion (tMCAO) in the mice brain up to 7 days after reperfusion...
October 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27306474/can-calpain-cathepsin-hypothesis-explain-alzheimer-neuronal-death
#18
Tetsumori Yamashima
Neurons are highly specialized post-mitotic cells, so their homeostasis and survival depend on the tightly-regulated, continuous protein degradation, synthesis, and turnover. In neurons, autophagy is indispensable to facilitate recycling of long-lived, damaged proteins and organelles in a lysosome-dependent manner. Since lysosomal proteolysis under basal conditions performs an essential housekeeping function, inhibition of the proteolysis exacerbates level of neurodegeneration. The latter is characterized by an accumulation of abnormal proteins or organelles within autophagic vacuoles which reveal as 'granulo-vacuolar degenerations' on microscopy...
June 13, 2016: Ageing Research Reviews
https://www.readbyqxmd.com/read/27297340/household-fuel-use-and-cardiovascular-disease-mortality-golestan-cohort-study
#19
Sumeet S Mitter, Rajesh Vedanthan, Farhad Islami, Akram Pourshams, Hooman Khademi, Farin Kamangar, Christian C Abnet, Sanford M Dawsey, Paul D Pharoah, Paul Brennan, Valentin Fuster, Paolo Boffetta, Reza Malekzadeh
BACKGROUND: Household air pollution is the third largest risk factor for global disease burden, but direct links with cardiovascular disease mortality are limited. This study aimed to evaluate the relationship between household fuel use and cardiovascular disease mortality. METHODS AND RESULTS: The Golestan Cohort Study in northeastern Iran enrolled 50 045 individuals 40 to 75 years of age between 2004 and 2008 and collected data on lifetime household fuel use and other baseline exposures...
June 14, 2016: Circulation
https://www.readbyqxmd.com/read/27280114/assessment-of-the-effect-of-cold-and-hot-temperatures-on-mortality-in-ontario-canada-a-population-based-study
#20
Hong Chen, Jun Wang, Qiongsi Li, Abderrahmane Yagouti, Eric Lavigne, Richard Foty, Richard T Burnett, Paul J Villeneuve, Sabit Cakmak, Ray Copes
BACKGROUND: Ambient high temperature is associated with death; however, heat-related risk of death has not been quantified systematically in Ontario, the most populous province in Canada. Less is known about cold-related risk in this population. Our objective was to quantify the health impact from cold and hot temperatures in Ontario. METHODS: The study population consisted of all residents of Ontario who died between Jan. 1, 1996, and Dec. 31, 2010, from any nonaccidental cause...
January 2016: CMAJ Open
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