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https://www.readbyqxmd.com/read/28101038/successful-management-in-a-case-of-traumatic-retinal-detachment-due-to-open-globe-injury-using-microincisional-vitrectomy
#1
Wei-Yu Lai, Tsung-Tien Wu
BACKGROUND: Retinal detachment (RD) following ocular trauma often results in guarded visual prognosis and sometimes leads to loss of the eye. With the advent of microincisional vitrectomy surgery and the development of surgical techniques, the management of ocular trauma has been transformed. CASE PRESENTATION: A 34-year-old man sustained an open globe injury from fragmented glass at work. He received primary repair and another follow-up surgery 9 days later, including vitrectomy, silicone oil tamponade, and lensectomy for RD and traumatic cataract at another medical center...
September 2016: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28100670/two-new-single-exposure-multi-detector-neutron-spectrometers-for-radiation-protection-applications-in-workplace-monitoring
#2
J M Gómez-Ros, R Bedogni, D Bortot, C Domingo, A Esposito, M V Introini, M Lorenzoli, G Mazzitelli, M Moraleda, A Pola, D Sacco
This communication describes two new instruments, based on multiple active thermal neutron detectors arranged within a single moderator, that permit to unfold the neutron spectrum (from thermal to hundreds of MeV) and to determine the corresponding integral quantities with only one exposure. This makes them especially advantageous for neutron field characterisation and workplace monitoring in neutron-producing facilities. One of the devices has spherical geometry and nearly isotropic response, the other one has cylindrical symmetry and it is only sensitive to neutrons incident along the cylinder axis...
January 17, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/28097675/the-swamplands-of-reflection-using-conversation-analysis-to-reveal-the-architecture-of-group-reflection-sessions
#3
Mario Veen, Anne de la Croix
CONTEXT: Many medical schools include group reflection in their curriculum, and many researchers have considered both the concept and the outcomes of reflection. However, no research has been carried out on how 'reflective talk' is structured in the classroom. This paper describes how tutors and residents organise group reflection sessions in situ by describing an example of group reflection in medical education. Our aim is to provide an evidence base that can be used by medical educators to think about the way reflection should be included in their curriculum...
January 18, 2017: Medical Education
https://www.readbyqxmd.com/read/28059091/identification-of-distinct-subgroups-of-ebv-positive-post-transplant-diffuse-large-b-cell-lymphoma
#4
Julie Morscio, Julio Finalet Ferreiro, Sara Vander Borght, Emilie Bittoun, Olivier Gheysens, Daan Dierickx, Gregor Verhoef, Iwona Wlodarska, Thomas Tousseyn
Post-transplantation lymphoproliferative disorder is an aggressive complication of transplantation, most frequently of diffuse large B-cell lymphoma morphology and associated with Epstein-Barr virus (EBV) infection/reactivation. In this study the microenvironment of EBV(+) (n=23) and EBV(-) (n=9) post-transplant non-germinal center B-cell diffuse large B-cell lymphoma was characterized. Of EBV(+) cases somatic hypermutation analysis, gene expression profiling, and extensive phenotyping were performed. Our results demonstrated variable cytotoxic T-cell infiltration and significantly increased CD163(+) M2 macrophage infiltration in EBV(+) compared with EBV(-) post-transplant diffuse large B-cell lymphoma...
January 6, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28046938/su-f-i-21-unfolding-of-aliased-dynamic-acquisitions-for-the-acceleration-of-breast-dynamic-contrast-enhanced-mri-dce-mri
#5
F Pineda, M Medved, X Fan, G Karczmar
PURPOSE: To determine the feasibility of increasing temporal resolution in breast DCE-MRI by reducing the field-of-view (FOV) and unfolding the aliased images using un-aliased subtraction images as guides. METHODS: Experience with an 'ultrafast' protocol for breast DCE-MRI (6-10s acquisitions) showed that the number of significantly enhancing voxels was very low (<7% of the FOV) in the first 30-45s after contrast injection. The sparse enhancement in these images suggests that if the FOV is reduced in the phase-encoding direction (reducing acquisition time) and aliasing occurs, the likelihood of two significantly-enhancing voxels overlapping in the aliased image is relatively low...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28043015/comparison-of-the-effectiveness-of-two-styles-of-case-based-learning-implemented-in-lectures-for-developing-nursing-students-critical-thinking-ability-a-randomized-controlled-trial
#6
Shaohua Hong, Ping Yu
PURPOSE: To explore and compare the effectiveness of two styles of case-based learning methods, unfolding nursing case and usual nursing case, implemented in lectures for developing nursing students' critical thinking ability. METHODS: 122 undergraduate nursing students in four classes were taught the subject of medical nursing for one year. Two classes were randomly assigned as the experimental group and the other two the control group. The experimental group received the lectures presenting unfolding nursing cases and the control group was taught the usual cases...
December 23, 2016: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28033550/alignment-in-social-interactions
#7
M Gallotti, M T Fairhurst, C D Frith
According to the prevailing paradigm in social-cognitive neuroscience, the mental states of individuals become shared when they adapt to each other in the pursuit of a shared goal. We challenge this view by proposing an alternative approach to the cognitive foundations of social interactions. The central claim of this paper is that social cognition concerns the graded and dynamic process of alignment of individual minds, even in the absence of a shared goal. When individuals reciprocally exchange information about each other's minds processes of alignment unfold over time and across space, creating a social interaction...
December 26, 2016: Consciousness and Cognition
https://www.readbyqxmd.com/read/28032989/how-does-your-protein-fold-elucidating-the-apomyoglobin-folding-pathway
#8
H Jane Dyson, Peter E Wright
Although each type of protein fold and in some cases individual proteins within a fold classification can have very different mechanisms of folding, the underlying biophysical and biochemical principles that operate to cause a linear polypeptide chain to fold into a globular structure must be the same. In an aqueous solution, the protein takes up the thermodynamically most stable structure, but the pathway along which the polypeptide proceeds in order to reach that structure is a function of the amino acid sequence, which must be the final determining factor, not only in shaping the final folded structure, but in dictating the folding pathway...
January 17, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28025808/backbone-resonance-assignments-of-monomeric-sod1-in-dilute-and-crowded-environments
#9
Naoto Iwakawa, Daichi Morimoto, Erik Walinda, Kenji Sugase, Masahiro Shirakawa
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that leads to movement disorders. In motor neurons of ALS patients, intracellular aggregates of superoxide dismutase 1 (SOD1) have often been observed. To elucidate the aggregation mechanism, it is important to analyze the folding equilibrium of SOD1 between folded and aggregation-prone unfolded states. However, in most cases, this folding equilibrium has been studied in dilute solution even though the aggregate formation occurs in a highly crowded intracellular environment...
December 26, 2016: Biomolecular NMR Assignments
https://www.readbyqxmd.com/read/28017766/folding-and-unfolding-pathway-of-chaperonin-groel-monomer-and-elucidation-of-thermodynamic-parameters
#10
Sarita Puri, Tapan K Chaudhuri
The conformation and thermodynamic stability of monomeric GroEL were studied by CD and fluorescence spectroscopy. GroEL denaturation with urea and dilution in buffer leads to formation of a folded GroEL monomer. The monomeric nature of this protein was verified by size-exclusion chromatography and native PAGE. It has a well-defined secondary and tertiary structure, folding activity (prevention of aggregation) for substrate protein and is resistant to proteolysis. Being a properly folded and reversibly refoldable, monomeric GroEL is amenable for the study of thermodynamic stability by unfolding transition methods...
December 23, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27973780/defining-non-covalent-ubiquitin-homodimer-interfacial-interactions-through-comparisons-with-covalently-linked-diubiquitin
#11
Nicole Wagner, David H Russell
Ubiquitin (Ubq) is a small protein that exhibits diverse biological functionality as defined by its oligomeric state and conformational preference. Covalently linked diubiquitin (diUbq) is known to adopt specific interfacial interactions owing to steric hindrance induced by the covalent tether. K48-linked diUbq preferentially forms hydrophobic interfacial interactions between the two I44 faces under physiological conditions, whereas K63-linked diUbq preferentially forms electrostatic interfacial interactions...
December 14, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27968869/cataract-screening-in-a-rural-area-of-southern-china-a-retrospective-cohort-study
#12
Xuhua Tan, Haotian Lin, YuTing Li, Li Huang, Yi Zhu, Yao Ni, WenYong Huang, Yizhi Liu
BACKGROUND: Cataract is the leading cause of blindness and impaired vision worldwide; however, cataract surgery rate in China (1300 cases per million people per year) is lower than in Europe, America, and India (greater than 5000 cases per million people per year). In the past 10 years, a public health screening system has been established for early diagnosis and intervention of chronic diseases such as diabetes and hypertension by the Disease Control and Prevention Centers (CDC) of China...
October 2016: Lancet
https://www.readbyqxmd.com/read/27966879/single-molecule-fret-measurements-in-additive-enriched-aqueous-solutions
#13
Daryan Kempe, Michele Cerminara, Simón Poblete, Antonie Schöne, Matteo Gabba, Jörg Fitter
The addition of high amounts of chemical denaturants, salts, viscosity enhancers or macro-molecular crowding agents has an impact on the physical properties of buffer solutions. Among others, the (microscopic) viscosity, the refractive index, the dielectric constant, and the ionic strength can be affected. Here, we systematically evaluate the importance of solvent characteristics with respect to single-molecule FRET (smFRET) data. First, we present a confocal based method for the determination of fluorescence quantum yields to facilitate a fast characterization of smFRET-samples at sub-nM-concentrations...
December 14, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27964946/predicting-the-effect-of-amino-acid-single-point-mutations-on-protein-stability-large-scale-validation-of-md-based-relative-free-energy-calculations
#14
Thomas Steinbrecher, Chongkai Zhu, Lingle Wang, Robert Abel, Christopher Negron, David Pearlman, Eric Feyfant, Jianxin Duan, Woody Sherman
The stability of folded proteins is critical to their biological function and for the efficacy of protein therapeutics. Predicting the energetic effects of protein mutations can improve our fundamental understanding of structural biology, the molecular basis of diseases, and possible routes to addressing those diseases with biological drugs. Identifying the effect of single amino acid point mutations on the thermodynamic equilibrium between the folded and unfolded states of a protein can pinpoint residues of critical importance that should be avoided in the process of improving other properties (affinity, solubility, viscosity, etc...
December 10, 2016: Journal of Molecular Biology
https://www.readbyqxmd.com/read/27920841/wolffian-origin-of-vagina-unfolds-the-embryopathogenesis-of-ohvira-obstructed-hemivagina-and-ipsilateral-renal-anomaly-syndrome-and-places-ohvira-as-a-female-counterpart-of-zinner-syndrome-in-males
#15
Yashant Aswani, Ravi Varma, Pradeep Choudhary, Reeta B Gupta
BACKGROUND: The classical theory of Müllerian origin of upper vagina fails to explain complex urogenital malformations like OHVIRA syndrome; the Acien's hypothesis, however, unravels the hidden embryopathogenesis. As per Acien, Wolffian (mesonephric) ducts instead of Müllerian ducts and sinovaginal bulbs, give rise to the vagina. The new hypothesis, however, retains the concept of origin of the ureters (with ureters inducing renal development) by the former and the uterus by Müllerian ducts...
2016: Polish Journal of Radiology
https://www.readbyqxmd.com/read/27912856/processes-of-developing-community-livability-in-older-age
#16
Kendra S Heatwole Shank, Malcolm P Cutchin
OBJECTIVE: 'Community livability' is a widely used term that is still under-conceptualized. The purpose of the project was to theorize key dynamics of livability for older adults who are aging in place in their homes and communities. METHODS: Twelve community-dwelling adults (70+) were recruited in a multiple-case study design. Interviews and naturalistic observations were used over the course of 6months. Global positioning system (GPS) devices were used to generate maps (routines, routes, type and duration of activities) to elicit additional insights through interviews...
December 2016: Journal of Aging Studies
https://www.readbyqxmd.com/read/27907139/contribution-towards-a-metabolite-profile-of-the-detoxification-of-benzoic-acid-through-glycine-conjugation-an-intervention-study
#17
Cindy Irwin, Mari van Reenen, Shayne Mason, Lodewyk J Mienie, Johan A Westerhuis, Carolus J Reinecke
Benzoic acid is widely used as a preservative in food products and is detoxified in humans through glycine conjugation. Different viewpoints prevail on the physiological significance of the glycine conjugation reaction and concerns have been raised on potential public health consequences following uncontrolled benzoic acid ingestion. We performed a metabolomics study which used commercial benzoic acid containing flavored water as vehicle for designed interventions, and report here on the controlled consumption of the benzoic acid by 21 cases across 6 time points for a total of 126 time points...
2016: PloS One
https://www.readbyqxmd.com/read/27893344/from-hallucination-to-fiction-the-invention-of-meaning-in-psychosis
#18
Silvia Lippi, Célia Lehaire, Laetitia Petit
Taking their inspiration from a case history, the authors explore the effects of a writing workshop led by a professional writer for patients in a psychiatric hospital. This workshop allowed different modes of transference to unfold: transference to the analyst-therapist, transference to the writer who led the workshop, and transference to the other members of the group. The writing activity created conditions in which there could be a movement from hallucination to delusion-a delusion expressed in fiction through the act of writing...
December 2016: Psychoanalytic Review
https://www.readbyqxmd.com/read/27871378/deciphering-the-factors-defining-the-ph-dependence-of-a-commercial-glycoside-hydrolase-family-8-enzyme
#19
Mário Barroca, Gustavo Santos, Björn Johansson, Florian Gillotin, Georges Feller, Tony Collins
A prerequisite to the use of any enzyme in any industrial process is an understanding of its activity and stability under process conditions. Glycoside hydrolase family 8 enzymes include many important biotechnological biocatalysts yet little is known of the performance of these with respect to pH. A better understanding of this parameter and its relationship to structure and function in these enzymes will allow for an improved use of these in industry as well as an enhanced ability in their engineering and optimisation for a particular application...
January 2017: Enzyme and Microbial Technology
https://www.readbyqxmd.com/read/27854344/unfolding-refolding-study-on-collagen-from-sea-cucumber-based-on-2d-fourier-transform-infrared-spectroscopy
#20
Lei Qin, Jing-Ran Bi, Dong-Mei Li, Meng Dong, Zi-Yuan Zhao, Xiu-Ping Dong, Da-Yong Zhou, Bei-Wei Zhu
We aimed to explore the differences of thermal behaviors between insoluble collagen fibrils (ICFs) and pepsin-solubilized collagens (PSCs) from sea cucumber Stichopus japonicus. The unfolding/refolding sequences of secondary structures of ICFs and PSCs during the heating and cooling cycle (5 → 70 → 5 °C) were identified by Fourier transform infrared spectrometry combined with curve-fitting and 2D correlation techniques. ICFs showed a higher proportion of α-helical structures and higher thermostability than PSCs, and thus had more-stable triple helical structures...
November 16, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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