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https://www.readbyqxmd.com/read/27920841/wolffian-origin-of-vagina-unfolds-the-embryopathogenesis-of-ohvira-obstructed-hemivagina-and-ipsilateral-renal-anomaly-syndrome-and-places-ohvira-as-a-female-counterpart-of-zinner-syndrome-in-males
#1
Yashant Aswani, Ravi Varma, Pradeep Choudhary, Reeta B Gupta
BACKGROUND: The classical theory of Müllerian origin of upper vagina fails to explain complex urogenital malformations like OHVIRA syndrome; the Acien's hypothesis, however, unravels the hidden embryopathogenesis. As per Acien, Wolffian (mesonephric) ducts instead of Müllerian ducts and sinovaginal bulbs, give rise to the vagina. The new hypothesis, however, retains the concept of origin of the ureters (with ureters inducing renal development) by the former and the uterus by Müllerian ducts...
2016: Polish Journal of Radiology
https://www.readbyqxmd.com/read/27912856/processes-of-developing-community-livability-in-older-age
#2
Kendra S Heatwole Shank, Malcolm P Cutchin
OBJECTIVE: 'Community livability' is a widely used term that is still under-conceptualized. The purpose of the project was to theorize key dynamics of livability for older adults who are aging in place in their homes and communities. METHODS: Twelve community-dwelling adults (70+) were recruited in a multiple-case study design. Interviews and naturalistic observations were used over the course of 6months. Global positioning system (GPS) devices were used to generate maps (routines, routes, type and duration of activities) to elicit additional insights through interviews...
December 2016: Journal of Aging Studies
https://www.readbyqxmd.com/read/27907139/contribution-towards-a-metabolite-profile-of-the-detoxification-of-benzoic-acid-through-glycine-conjugation-an-intervention-study
#3
Cindy Irwin, Mari van Reenen, Shayne Mason, Lodewyk J Mienie, Johan A Westerhuis, Carolus J Reinecke
Benzoic acid is widely used as a preservative in food products and is detoxified in humans through glycine conjugation. Different viewpoints prevail on the physiological significance of the glycine conjugation reaction and concerns have been raised on potential public health consequences following uncontrolled benzoic acid ingestion. We performed a metabolomics study which used commercial benzoic acid containing flavored water as vehicle for designed interventions, and report here on the controlled consumption of the benzoic acid by 21 cases across 6 time points for a total of 126 time points...
2016: PloS One
https://www.readbyqxmd.com/read/27893344/from-hallucination-to-fiction-the-invention-of-meaning-in-psychosis
#4
Silvia Lippi, Célia Lehaire, Laetitia Petit
Taking their inspiration from a case history, the authors explore the effects of a writing workshop led by a professional writer for patients in a psychiatric hospital. This workshop allowed different modes of transference to unfold: transference to the analyst-therapist, transference to the writer who led the workshop, and transference to the other members of the group. The writing activity created conditions in which there could be a movement from hallucination to delusion-a delusion expressed in fiction through the act of writing...
December 2016: Psychoanalytic Review
https://www.readbyqxmd.com/read/27871378/deciphering-the-factors-defining-the-ph-dependence-of-a-commercial-glycoside-hydrolase-family-8-enzyme
#5
Mário Barroca, Gustavo Santos, Björn Johansson, Florian Gillotin, Georges Feller, Tony Collins
A prerequisite to the use of any enzyme in any industrial process is an understanding of its activity and stability under process conditions. Glycoside hydrolase family 8 enzymes include many important biotechnological biocatalysts yet little is known of the performance of these with respect to pH. A better understanding of this parameter and its relationship to structure and function in these enzymes will allow for an improved use of these in industry as well as an enhanced ability in their engineering and optimisation for a particular application...
January 2017: Enzyme and Microbial Technology
https://www.readbyqxmd.com/read/27854344/unfolding-refolding-study-on-collagen-from-sea-cucumber-based-on-2d-fourier-transform-infrared-spectroscopy
#6
Lei Qin, Jing-Ran Bi, Dong-Mei Li, Meng Dong, Zi-Yuan Zhao, Xiu-Ping Dong, Da-Yong Zhou, Bei-Wei Zhu
We aimed to explore the differences of thermal behaviors between insoluble collagen fibrils (ICFs) and pepsin-solubilized collagens (PSCs) from sea cucumber Stichopus japonicus. The unfolding/refolding sequences of secondary structures of ICFs and PSCs during the heating and cooling cycle (5 → 70 → 5 °C) were identified by Fourier transform infrared spectrometry combined with curve-fitting and 2D correlation techniques. ICFs showed a higher proportion of α-helical structures and higher thermostability than PSCs, and thus had more-stable triple helical structures...
November 16, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27854036/hydrophobic-interaction-between-domain-i-of-albumin-and-b-chain-of-detemir-may-support-myristate-dependent-detemir-albumin-binding
#7
Sadaf Fatima, Priyankar Sen, P Sneha, C George Priyadoss
The bindings of detemir [LysB29(Nε-tetradecanoyl)des(B30)-insulin] with two highly homologous albumins, HSA (human serum albumin) and BSA (bovine serum albumin), were investigated through CD, spectrofluorophotometry, and molecular docking analysis. The absence of any tryptophanyl residue in detemir makes albumin binding study possible by exclusive tryptophanyl spectral quenching at 340 nm (λem = 296 nm). The interactions found to be static (Kq > 10(10) M(-1) s(-1)) with Stern-Volmer constants ≈10(3) M(-1)...
November 16, 2016: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/27833250/cytohistological-discordance-on-gastrointestinal-brushings-facts-unfolded
#8
Ruchita Tyagi, Jagpal Kaur, Gursheen Kaur, Pavneet Kaur Selhi, Harpreet Kaur Puri, Neena Sood
INTRODUCTION: Brush cytology is a rapid, cost-effective, and reliable tool to diagnose gastrointestinal tract (GIT) lesions in low-resource settings. Most of the studies on GIT brushings have focused on upper GI lesions. We have studied the diagnostic accuracy of brush cytology in the entire length of GIT and correlated the cytological diagnosis with histopathology. The aim of this study is to study diagnostic utility of brush cytology of GIT lesions in the context of correlation with biopsy and study the factors responsible for cytohistological discordance...
September 2016: Nigerian Medical Journal: Journal of the Nigeria Medical Association
https://www.readbyqxmd.com/read/27830911/research-ethics-on-the-agenda-the-debates-preceding-the-establishment-of-the-ethics-committees
#9
Nadia Shad Paulsen, Anne Kveim Lie
BACKGROUND This article examines two factors that helped to trigger and drive forward the debate about research ethics committees (now the Regional Committees for Medical and Health Research Ethics) in Norway in the 1970s: the revision of the Declaration of Helsinki by a Scandinavian working group, and the unfolding of the so-called Gro case in the Norwegian national media.METHOD We have used existing literature in the form of books and articles on the history of research ethics from the University Library of the University of Oslo, the National Library of Norway, the History of Science, Technology and Medicine database, and Retriever...
November 2016: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
https://www.readbyqxmd.com/read/27825238/on-the-polymer-physics-origins-of-protein-folding-thermodynamics
#10
Mark P Taylor, Wolfgang Paul, Kurt Binder
A remarkable feature of the spontaneous folding of many small proteins is the striking similarity in the thermodynamics of the folding process. This process is characterized by simple two-state thermodynamics with large and compensating changes in entropy and enthalpy and a funnel-like free energy landscape with a free-energy barrier that varies linearly with temperature. One might attribute the commonality of this two-state folding behavior to features particular to these proteins (e.g., chain length, hydrophobic/hydrophilic balance, attributes of the native state) or one might suspect that this similarity in behavior has a more general polymer-physics origin...
November 7, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/27813412/a-sliding-contact-dynamic-force-spectroscopy-method-for-interrogating-slowly-forming-polymer-crosslinks
#11
Kate Alexandra Bowman, Olav Andreas Aarstad, Bjørn Torger Stokke, Gudmund Skjåk-Bræk, Andrew N Round
Dynamic Single Molecule Force Spectroscopy (SMFS), conducted most commonly using AFM, has become a widespread and valuable tool for understanding the kinetics and thermodynamics of fundamental molecular processes such as ligand-receptor interactions and protein unfolding. Where slowly forming bonds are responsible for the primary characteristics of a material, as is the case in crosslinks in some polymer gels, care must be taken to ensure that a fully equilibrated bond has first formed before its rupture can be interpreted...
November 4, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/27797186/a-sapt-energy-analysis-of-alkyl-fluorine-aromatic-interactions-in-torsion-balance-systems
#12
Mary C Sherman, Mark R Ams, Kenneth D Jordan
Symmetry-adapted perturbation theory (SAPT) calculations are carried out to elucidate the intermolecular interactions present between fluorinated and non-fluorinated alkyl chain groups and aromatic π systems in the folded and unfolded conformers of Wilcox torsion balance systems. The calculations predict the folded conformers to be 2.0-2.3 kcal/mol more stable than the unfolded conformers, with the preference for the folded conformer being greater in the fluorinated alkyl chain case. We also establish that a simple electrostatic analysis, based on atomic charges, is inadequate for understanding the conformational preferences of these systems...
October 31, 2016: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/27793194/activation-of-the-unfolded-protein-response-and-granulovacuolar-degeneration-are-not-common-features-of-human-prion-pathology
#13
Vera I Wiersma, Wim van Hecke, Wiep Scheper, Martijn A J van Osch, Will J M Hermsen, Annemieke J M Rozemuller, Jeroen J M Hoozemans
Human prion diseases are fatal neurodegenerative disorders with a genetic, sporadic or infectiously acquired aetiology. Neuropathologically, human prion diseases are characterized by deposition of misfolded prion protein and neuronal loss. In post-mortem brain tissue from patients with other neurodegenerative diseases characterized by protein misfolding, including Alzheimer's disease (AD) and frontotemporal lobar degeneration with tau pathology (FTLD-tau), increased activation of the unfolded protein response (UPR) has been observed...
October 28, 2016: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/27793091/cosplicenet-a-framework-for-co-splicing-network-inference-from-transcriptomics-data
#14
Delasa Aghamirzaie, Eva Collakova, Song Li, Ruth Grene
BACKGROUND: Alternative splicing has been proposed to increase transcript diversity and protein plasticity in eukaryotic organisms, but the extent to which this is the case is currently unclear, especially with regard to the diversification of molecular function. Eukaryotic splicing involves complex interactions of splicing factors and their targets. Inference of co-splicing networks capturing these types of interactions is important for understanding this crucial, highly regulated post-transcriptional process at the systems level...
October 28, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27787826/intrinsic-disorder-and-semi-disorder-prediction-by-spine-d
#15
Tuo Zhang, Eshel Faraggi, Zhixiu Li, Yaoqi Zhou
Over the past decade, it has become evident that a large proportion of proteins contain intrinsically disordered regions, which play important roles in pivotal cellular functions. Many computational tools have been developed with the aim of identifying the level and location of disorder within a protein. In this chapter, we describe a neural network based technique called SPINE-D that employs a unique three-state design and can accurately capture disordered residues in both short and long disordered regions...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27762577/saccadic-eye-movements-impose-a-natural-bottleneck-on-visual-short-term-memory
#16
Sven Ohl, Martin Rolfs
Visual short-term memory (VSTM) is a crucial repository of information when events unfold rapidly before our eyes, yet it maintains only a fraction of the sensory information encoded by the visual system. Here, we tested the hypothesis that saccadic eye movements provide a natural bottleneck for the transition of fragile content in sensory memory to VSTM. In 4 experiments, we show that saccades, planned and executed after the disappearance of a memory array, markedly bias visual memory performance. First, items that had appeared at the saccade target were more readily remembered than items that had appeared elsewhere, even though the saccade was irrelevant to the memory task (Experiment 1)...
October 20, 2016: Journal of Experimental Psychology. Learning, Memory, and Cognition
https://www.readbyqxmd.com/read/27762571/how-suspect-race-affects-police-use-of-force-in-an-interaction-over-time
#17
Kimberly Barsamian Kahn, Joel S Steele, Jean M McMahon, Greg Stewart
Although studies often find racial disparities in policing outcomes, less is known about how suspect race biases police interactions as they unfold. This study examines what is differentially occurring during police-suspect interactions for White, Black, and Latino suspects across time. It is hypothesized that racial bias may be more evident earlier in interactions, when less information about the situation is available. One hundred thirty-nine (62 White, 42 Black, and 35 Latino) use-of-force case files and associated written narratives from a medium to large size urban police department in the United States were analyzed...
October 20, 2016: Law and Human Behavior
https://www.readbyqxmd.com/read/27759708/treatment-of-macular-folds-complicating-retinal-detachment-surgery-using-air-for-retinal-unfolding
#18
Pierre-Olivier Barale, Paolo Mora, Marie-Hélène Errera, Raphaëlle Ores, Michel Pâques, José-Alain Sahel
PURPOSE: We discuss a modified surgical procedure for the treatment of macular folds complicating retinal reattachment surgery. METHODS: To facilitate the completion of the macular redetachment and the subsequent unrolling of the fold, we propose the subretinal injection, in addition to the conventional balanced salt solution, of filtered air as an original approach. In the presence of a subretinal air bubble, the action of gravity on the perfluorocarbon liquid in the vitreous cavity combined with an active globe manipulation proved to be very effective for flattening the central retina...
October 18, 2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/27746352/nanoparticles-protein-interaction-role-in-protein-aggregation-and-clinical-implications
#19
REVIEW
Romana Parveen, Tooba Naz Shamsi, Sadaf Fatima
This review helps to understand protein misfolding events, which results in protein aggregation, and hence to related neurodegenerative diseases. Many chaperones and folding factors are found inside the cell system for the proper folding of protein. If protein gets misfolded, it may accumulate in cells and can lead to several fatal diseases. In some cases, misfolded proteins aggregated in form of loop-sheet polymer and amyloid fibril when they escape the degradation process and leads to neurodegenerative disorders...
October 13, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27718460/sculpting-3d-spatial-selectivity-with-pairs-of-2d-pulses-a-comparison-of-methods
#20
Gil Farkash, Jean-Nicolas Dumez, Lucio Frydman
Enhancing the specificity of the spins' excitation can improve the capabilities of magnetic resonance. Exciting voxels with tailored 3D shapes reduces partial volume effects and enhances contrast, particularly in cases where cubic voxels or other simple geometries do not provide an optimal localization. Spatial excitation profiles of arbitrary shapes can be implemented using so-called multidimensional RF pulses, which are often limited in practice to 2D implementations owing to their sensitivity to field inhomogeneities...
September 6, 2016: Journal of Magnetic Resonance
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