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https://www.readbyqxmd.com/read/28531308/challenges-of-research-recruitment-in-a-university-setting-in-england
#1
Claudia Vadeboncoeur, Charlie Foster, Nick Townsend
The recruitment is an integral part of most research projects in medical sciences involving human participants. In health promotion research, there is increasing work on the impact of environments. Settings represent environments such as schools where social, physical and psychological development unfolds. In this study, we investigated weight gain in students within a university setting. Barriers to access and recruitment of university students within a specific setting, in the context of health research are discussed...
May 20, 2017: Health Promotion International
https://www.readbyqxmd.com/read/28520725/reading-positional-codes-with-fmri-problems-and-solutions
#2
Kristjan Kalm, Dennis Norris
Neural mechanisms which bind items into sequences have been investigated in a large body of research in animal neurophysiology and human neuroimaging. However, a major problem in interpreting this data arises from a fact that several unrelated processes, such as memory load, sensory adaptation, and reward expectation, also change in a consistent manner as the sequence unfolds. In this paper we use computational simulations and data from two fMRI experiments to show that a host of unrelated neural processes can masquerade as sequence representations...
2017: PloS One
https://www.readbyqxmd.com/read/28518150/cycloheximide-promotes-paraptosis-induced-by-inhibition-of-cyclophilins-in-glioblastoma-multiforme
#3
Lin Wang, Justin H Gundelach, Richard J Bram
Cancer is the second leading cause of death worldwide. Current treatment strategies based on multi-agent chemotherapy and/or radiation regimens have improved overall survival in some cases. However, resistance to apoptosis often develops in cancer cells, and its occurrence is thought to contribute to treatment failure. Non-apoptotic cell death mechanisms have become of great interest, therefore, in hopes that they would bypass tumor cell resistance. Glioblastoma multiforme (GBM), a grade IV astrocytic tumor is the most frequent brain tumor in adults, and has a high rate of mortality...
May 18, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28513968/the-views-of-ethics-committee-members-and-medical-researchers-on-the-return-of-individual-research-results-and-incidental-findings-ownership-issues-and-benefit-sharing-in-biobanking-research-in-a-south-indian-city
#4
Manjulika Vaz, Mario Vaz, Srinivasan K
The return of individual research results and incidental findings from biobanking research is a much debated ethical issue globally but has extensive relevance in India where the burden of out of pocket health care expenses is high for the majority. The views of 21 ethics committee (EC) members and 22 researchers from Bengaluru, India, concerning the ethics of biobanking research were sought through in-depth interviews using an unfolding case vignette with probes. A shared view among most was that individual research results which are 'actionable' or have 'clinical significance' should be returned to the sample contributors through their treating physicians...
May 17, 2017: Developing World Bioethics
https://www.readbyqxmd.com/read/28509654/clinical-reasoning-embodied-meaning-making-in-physiotherapy
#5
Anoop Chowdhury, Wenche Schrøder Bjorbækmo
This article examines physiotherapists' lived experience of practicing physiotherapy in primary care, focusing on clinical reasoning and decision-making in the case of a patient we call Eva. The material presented derives from a larger study involving two women participants, both with a protracted history of neck and shoulder pain. A total of eight sessions, all of them conducted by the first author, a professional physiotherapist, in his own practice room, were videotaped, after which the first author transcribed the sessions and added reflective notes...
May 16, 2017: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/28500055/rnai-mediated-reverse-genetic-screen-identified-drosophila-chaperones-regulating-eye-and-neuromuscular-junction-morphology
#6
Sandeep Raut, Bhagaban Mallik, Arpan Parichha, Amrutha V, Chandan Sahi, Vimlesh Kumar
Accumulation of toxic proteins in neurons have been linked with the onset of neurodegenerative diseases, which in many cases, are characterized by altered neuronal function and synapse loss. Molecular chaperones help protein folding and resolubilization of unfolded proteins thereby reducing the protein aggregation stress. While most of the chaperones are expressed in neurons, their functional relevance largely remains unknown. Here, using bioinformatics analysis, we identified 95 Drosophila chaperones and classified them into seven different classes...
May 12, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28491032/topological-filtering-of-dynamic-functional-brain-networks-unfolds-informative-chronnectomics-a-novel-data-driven-thresholding-scheme-based-on-orthogonal-minimal-spanning-trees-omsts
#7
Stavros I Dimitriadis, Christos Salis, Ioannis Tarnanas, David E Linden
The human brain is a large-scale system of functionally connected brain regions. This system can be modeled as a network, or graph, by dividing the brain into a set of regions, or "nodes," and quantifying the strength of the connections between nodes, or "edges," as the temporal correlation in their patterns of activity. Network analysis, a part of graph theory, provides a set of summary statistics that can be used to describe complex brain networks in a meaningful way. The large-scale organization of the brain has features of complex networks that can be quantified using network measures from graph theory...
2017: Frontiers in Neuroinformatics
https://www.readbyqxmd.com/read/28481833/air-pump-assisted-graft-centration-graft-edge-unfolding-and-graft-uncreasing-in-young-donor-graft-pre-descemet-endothelial-keratoplasty
#8
Soosan Jacob, Smita Narasimhan, Amar Agarwal, Athiya Agarwal, Saijimol A I
PURPOSE: To assess an air pump-assisted technique for graft centration, graft edge unfolding, and graft uncreasing while performing pre-Descemet endothelial keratoplasty (PDEK) using young donor grafts. METHODS: Continuous pressurized air infusion was used for graft centration, graft edge unfolding, and graft unwrinkling. RESULTS: Ten eyes of 10 patients underwent PDEK with donors aged below 40 years. In all eyes, the donor scrolled into tight scrolls...
May 3, 2017: Cornea
https://www.readbyqxmd.com/read/28474792/molecular-stretching-modulates-mechanosensing-pathways
#9
REVIEW
Xian Hu, Felix Margadant, Mingxi Yao, Michael Sheetz
For individual cells in tissues to create the diverse forms of biological organisms, it is necessary that they must reliably sense and generate the correct forces over the correct distances and directions. There is considerable evidence that the mechanical aspects of the cellular microenvironment provide critical physical parameters to be sensed. How proteins sense forces and cellular geometry to create the correct morphology is not understood in detail but protein unfolding appears to be a major component in force and displacement sensing...
May 5, 2017: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/28470663/mechanical-deformation-accelerates-protein-ageing
#10
Jessica Valle Orero, Jaime Andres Rivas-Pardo, Rafael Tapia-Rojo, Ionel Popa, Daniel J Echelman, Shubhasis Haldar, Julio M Fernandez
A hallmark of tissue ageing is the irreversible oxidative modifications of its constituent proteins. We show that single proteins, kept unfolded and extended by a mechanical force, undergo accelerated ageing in times scales of minutes to days. A protein forced to be continuously unfolded, loses completely its ability to contract by folding becoming a labile polymer. Ageing rates vary amongst different types of proteins, but in all cases they lose their mechanical integrity. Random oxidative modification of cryptic side chains exposed by mechanical unfolding can be slowed by the addition of antioxidants such as ascorbic acid, or accelerated by oxidants...
May 3, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28467788/sphingosine-kinase-2-inhibition-synergises-with-bortezomib-to-target-myeloma-by-enhancing-endoplasmic-reticulum-stress
#11
Craig T Wallington-Beddoe, Melissa K Bennett, Kate Vandyke, Lorena Davies, Julia R Zebol, Paul A B Moretti, Melissa R Pitman, Duncan R Hewett, Andrew C W Zannettino, Stuart M Pitson
The proteasome inhibitor bortezomib has proven to be invaluable in the treatment of myeloma. By exploiting the inherent high immunoglobulin protein production of malignant plasma cells, bortezomib induces endoplasmic reticulum (ER) stress and the unfolded protein response (UPR), resulting in myeloma cell death. In most cases, however, the disease remains incurable highlighting the need for new therapeutic targets. Sphingosine kinase 2 (SK2) has been proposed as one such therapeutic target for myeloma. Our observations that bortezomib and SK2 inhibitors independently elicited induction of ER stress and the UPR prompted us to examine potential synergy between these agents in myeloma...
April 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28466116/cultural-sensitive-care-provision-in-a-public-child-and-adolescent-mental-health-centre-a-case-study-from-the-toulouse-university-hospital-intercultural-consultation
#12
Gesine Sturm, Sylvie Bonnet, Yolaine Coussot, Katja Journot, Jean-Philippe Raynaud
Child and adolescent mental health services in Europe are confronted with children with increasingly diverse socio-cultural backgrounds. Clinicians encounter cultural environments of hyperdiversity in terms of languages and countries of origin, growing diversity within groups, and accelerated change with regards to social and administrational situations (Hannah, in: DelVecchio Good et al. (eds) Shattering culture: American medicine responds to cultural diversity, Russel Sage Foundation, New York, 2011). Children and families who live in these complex constellations face multiple vulnerabilizing factors related to overlapping or intersecting social identities (Crenshaw in Univ Chic Leg Forum 140:139-167, 1989)...
May 2, 2017: Culture, Medicine and Psychiatry
https://www.readbyqxmd.com/read/28435474/the-vision-of-industrie-4-0-in-the-making-a-case-of-future-told-tamed-and-traded
#13
Sabine Pfeiffer
Since industrial trade fair Hannover Messe 2011, the term "Industrie 4.0" has ignited a vision of a new Industrial Revolution and has been inspiring a lively, ongoing debate among the German public about the future of work, and hence society, ever since. The discourse around this vision of the future eventually spread to other countries, with public awareness reaching a temporary peak in 2016 when the World Economic Forum's meeting in Davos was held with the motto "Mastering the Fourth Industrial Revolution...
2017: Nanoethics
https://www.readbyqxmd.com/read/28425289/imaging-metastable-states-and-transitions-in-proteins-by-trajectory-map
#14
Chuanbiao Zhang, Jin Yu, Xin Zhou
It has been a long-standing and intriguing issue to develop robust methods to identify metastable states and interstate transitions from simulations or experimental data to understand the functional conformational changes of proteins. It is usually hard to define the complicated boundaries of the states in the conformational space using most of the existing methods, and they often lead to parameter-sensitive results. Here, we present a new approach, visualized Trajectory Map (vTM), to identify the metastable states and the rare interstate transitions, by considering both the conformational similarity and the temporal successiveness of conformations...
May 11, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28419507/a-rapid-solvent-accessible-surface-area-estimator-for-coarse-grained-molecular-simulations
#15
Shuai Wei, Charles L Brooks, Aaron T Frank
The rapid and accurate calculation of solvent accessible surface area (SASA) is extremely useful in the energetic analysis of biomolecules. For example, SASA models can be used to estimate the transfer free energy associated with biophysical processes, and when combined with coarse-grained simulations, can be particularly useful for accounting for solvation effects within the framework of implicit solvent models. In such cases, a fast and accurate, residue-wise SASA predictor is highly desirable. Here, we develop a predictive model that estimates SASAs based on Cα-only protein structures...
June 5, 2017: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/28402469/health-system-functionality-in-a-low-income-country-in-the-midst-of-conflict-the-case-of-yemen
#16
Naseeb Qirbi, Sharif A Ismail
Background:  Although the literature on effects of armed conflict on population health is extensive, detailed assessments of effects on public health 'systems' are few. This article aims to help address this deficit through the medium of a case study on Yemen, describing health system and health outcome performance prior to the internationalisation of the conflict there in March 2015, before assessing the impact of war on health system functionality since that time. Method : Review of peer- and non-peer reviewed literature from 2005 to 2016 from academic sources, multilateral organizations, donors and governmental and non-governmental organizations, augmented by secondary data analysis...
April 11, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/28401474/tracking-effects-of-sil1-increase-taking-a-closer-look-beyond-the-consequences-of-elevated-expression-level
#17
Thomas Labisch, Stephan Buchkremer, Vietxuan Phan, Laxmikanth Kollipara, Christian Gatz, Chris Lentz, Kay Nolte, Jörg Vervoorts, José Andrés González Coraspe, Albert Sickmann, Stephanie Carr, René P Zahedi, Joachim Weis, Andreas Roos
SIL1 acts as a co-chaperone for the major ER-resident chaperone BiP and thus plays a role in many BiP-dependent cellular functions such as protein-folding control and unfolded protein response. Whereas the increase of BiP upon cellular stress conditions is a well-known phenomenon, elevation of SIL1 under stress conditions was thus far solely studied in yeast, and different studies indicated an adverse effect of SIL1 increase. This is seemingly in contrast with the beneficial effect of SIL1 increase in surviving neurons in neurodegenerative disorders such as amyotrophic lateral sclerosis and Alzheimer's disease...
April 11, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28397157/the-dynamics-of-de-adoption-a-case-study-of-policy-change-de-adoption-and-replacement-of-an-evidence-based-hiv-intervention
#18
Virginia R McKay, M Margaret Dolcini, Lee D Hoffer
Evidence-based intervention (EBI) de-adoption and its influence on public health organizations are largely unexplored within public health implementation research. However, a recent shift in support for HIV prevention EBIs by the Centers for Disease Control and Prevention provides an opportunity to explore EBI de-adoption. The current mixed-method study examines EBI de-adoption and the subsequent impact on a community-based organization (CBO) dedicated to HIV prevention. We conducted a case study with a CBO implementing RESPECT, an HIV prevention EBI, over 5 years (2010-2014), but then de-adopted the intervention...
April 10, 2017: Translational Behavioral Medicine
https://www.readbyqxmd.com/read/28390054/virtual-patients-in-a-behavioral-medicine-massive-open-online-course-mooc-a-qualitative-and-quantitative-analysis-of-participants-perceptions
#19
Anne H Berman, Gabriele Biguet, Natalia Stathakarou, Beata Westin-Hägglöf, Kerstin Jeding, Cormac McGrath, Nabil Zary, Andrzej A Kononowicz
OBJECTIVE: The purpose of this article is to explore learners' perceptions of using virtual patients in a behavioral medicine Massive Open Online Course (MOOCs) and thereby describe innovative ways of disseminating knowledge in health-related areas. METHODS: A 5-week MOOC on behavioral medicine was hosted on the edX platform. The authors developed two branched virtual patients consisting of video recordings of a live standardized patient, with multiple clinical decision points and narration unfolding depending on learners' choices...
April 7, 2017: Academic Psychiatry
https://www.readbyqxmd.com/read/28390017/interaction-of-tio2-nanoparticles-with-proteins-from-aquatic-organisms-the-case-of-gill-mucus-from-blue-mussel
#20
Adeline Bourgeault, Véronique Legros, Florence Gonnet, Regis Daniel, Aurélie Paquirissamy, Clémence Bénatar, Olivier Spalla, Corinne Chanéac, Jean-Philippe Renault, Serge Pin
To better understand the mechanisms of TiO2 nanoparticle (NP) uptake and toxicity in aquatic organisms, we investigated the interaction of NPs with the proteins found in gill mucus from blue mussels. Mucus is secreted by many aquatic organisms and is often their first line of defense against pathogens, xenobiotics, and other sources of environmental stress. Here, five TiO2 NPs and one SiO2 NP were incubated with gill mucus and run out on a one-dimensional polyacrylamide gel for a comparative qualitative analysis of the free proteins in the mucosal solution and the proteins bound to NPs...
April 7, 2017: Environmental Science and Pollution Research International
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