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Blood Oxygenation Level Dependent

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https://www.readbyqxmd.com/read/28645869/real-time-changes-in-brain-activity-during-sacral-neuromodulation-for-overactive-bladder
#1
Bradley C Gill, Javier Pizarro Berdichevsky, Pallab K Bhattacharyya, Thaddeus S Brink, Brian K Marks, Adrienne Quirouet, Sandip P Vasavada, Stephen E Jones, Howard B Goldman
PURPOSE: To use functional magnetic resonance imaging(fMRI) for identifying changes in brain activity during sacral neuromodulation(SNM) in women with overactive bladder(OAB) who were responsive to therapy. MATERIALS AND METHODS: Women with non-neurogenic refractory OAB who responded to SNM, had a stable program for at least 3 months, with no subsequent OAB treatment were recruited. Enrolled patients completed pre-fMRI validated symptom and quality of life instruments...
June 20, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28637813/contribution-of-blood-oxygen-and-carbon-dioxide-sensing-to-the-energetic-optimization-of-human-walking
#2
Jeremy D Wong, Shawn M O'Connor, Jessica C Selinger, J Maxwell Donelan
People can adapt their gait to minimize energetic cost, indicating that walking's neural control has access to ongoing measurements of the body's energy use. Here we test the hypothesis that an important source of energetic cost measurements arises from blood gas receptors that are sensitive to oxygen and carbon dioxide concentrations. These receptors are known to play a role in regulating other physiological processes related to energy consumption, such as ventilation rate. And due to the role of oxygen and carbon dioxide in oxidative metabolism, sensing their levels can provide an accurate estimate of the body's total energy use...
June 21, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28634048/activation-volume-vs-bold-signal-change-as-measures-of-fmri-activation-its-impact-on-gaba-fmri-activation-correlation
#3
Pallab K Bhattacharyya, Micheal D Phillips, Lael A Stone, Mark J Lowe
PURPOSE: To explore the relative robustness of functional MRI (fMRI) activation volume and blood oxygen level-dependent (BOLD) signal change as fMRI metric, and to study the effect of relative robustness on the correlation between fMRI activation and cortical gamma amino butyric acid (GABA) in healthy controls and patients with multiple sclerosis (MS). METHODS: fMRI data were acquired from healthy controls and patients with MS, with the subjects peforming self paced bilateral finger tapping in block design...
June 17, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28630232/long-noncoding-rna-h19-promotes-neuroinflammation-in-ischemic-stroke-by-driving-histone-deacetylase-1-dependent-m1-microglial-polarization
#4
Jue Wang, Haiping Zhao, Zhibin Fan, Guangwen Li, Qingfeng Ma, Zhen Tao, Rongliang Wang, Juan Feng, Yumin Luo
BACKGROUND AND PURPOSE: Long noncoding RNA H19 is repressed after birth, but can be induced by hypoxia. We aim to investigate the impact on and underlying mechanism of H19 induction after ischemic stroke. METHODS: Circulating H19 levels in stroke patients and mice subjected to middle cerebral artery occlusion were assessed using real-time polymerase chain reaction. H19 siRNA and histone deacetylase 1 (HDAC1) plasmid were used to knock down H19 and overexpress HDAC1, respectively...
June 19, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28628224/human-exposure-to-power-frequency-magnetic-fields-up-to-7-6%C3%A2-mt-an-integrated-eeg-fmri-study
#5
Julien Modolo, Alex W Thomas, Alexandre Legros
We assessed the effects of power-line frequency (60 Hz in North America) magnetic fields (MF) in humans using simultaneous electroencephalography (EEG) and functional magnetic resonance imaging (fMRI). Twenty-five participants were enrolled in a pseudo-double-blind experiment involving "real" or "sham" exposure to sinusoidal 60 Hz MF exposures delivered using the gradient coil of an MRI scanner following two conditions: (i) 10 s exposures at 3 mT (10 repetitions); (ii) 2 s exposures at 7.6 mT (100 repetitions)...
June 19, 2017: Bioelectromagnetics
https://www.readbyqxmd.com/read/28626199/oxygen-and-glucose-as-stimulation-agents-for-bold-functional-mr-imaging-of-rabbit-liver-a-feasibility-study
#6
Fang Yuan, Bin Song, Zixing Huang, Xijiao Liu, Chunchao Xia
PURPOSE: To assess the feasibility of using oxygen and glucose as stimulating agents in blood-oxygen-level-dependent (BOLD) Functional Magnetic Resonance Imaging (fMRI) of rabbit liver and analyze the impacts by blood flow. METHODS: Pure oxygen inhalation, intravenous injection and oral administration of glucose were given to 11 New Zealand white rabbits to compare the differences of liver T2*, aortic flow (AF), portal vein flow (PVF), aortic area (AA) and portal vein area (PVA) before and at 5 min, 10 min, 20 min, 30 min after administrations...
June 16, 2017: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/28623277/in-vivo-quantification-of-placental-insufficiency-by-bold-mri-a-human-study
#7
Jie Luo, Esra Abaci Turk, Carolina Bibbo, Borjan Gagoski, Drucilla J Roberts, Mark Vangel, Clare M Tempany-Afdhal, Carol Barnewolt, Judy Estroff, Arvind Palanisamy, William H Barth, Chloe Zera, Norberto Malpica, Polina Golland, Elfar Adalsteinsson, Julian N Robinson, Patricia Ellen Grant
Fetal health is critically dependent on placental function, especially placental transport of oxygen from mother to fetus. When fetal growth is compromised, placental insufficiency must be distinguished from modest genetic growth potential. If placental insufficiency is present, the physician must trade off the risk of prolonged fetal exposure to placental insufficiency against the risks of preterm delivery. Current ultrasound methods to evaluate the placenta are indirect and insensitive. We propose to use Blood-Oxygenation-Level-Dependent (BOLD) MRI with maternal hyperoxia to quantitatively assess mismatch in placental function in seven monozygotic twin pairs naturally matched for genetic growth potential...
June 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28617928/expectation-modulates-repetition-priming-under-high-stimulus-variability
#8
Maria Olkkonen, Geoffrey K Aguirre, Russell A Epstein
Neural responses to stimuli are often attenuated by repeated presentation. When observed in blood oxygen level-dependent signals, this attenuation is known as fMRI adaptation (fMRIa) or fMRI repetition suppression. According to a prominent account, fMRIa reflects the fulfillment of perceptual expectations during recognition of repeated items (Summerfield, Trittschuh, Monti, Mesulam, & Egner, 2008). Supporting this idea, expectation has been shown to modulate fMRIa under some circumstances; however, it is not currently known whether expectation similarly modulates recognition performance...
June 1, 2017: Journal of Vision
https://www.readbyqxmd.com/read/28611613/simultaneous-processing-of-noun-cue-and-to-be-produced-verb-in-verb-generation-task-electromagnetic-evidence
#9
Anna V Butorina, Anna A Pavlova, Anastasia Y Nikolaeva, Andrey O Prokofyev, Denis P Bondarev, Tatiana A Stroganova
A long-standing but implicit assumption is that words strongly associated with a presented cue are automatically activated in the memory through rapid spread of activation within brain semantic networks. The current study was aimed to provide direct evidence of such rapid access to words' semantic representations and to investigate its neural sources using magnetoencephalography (MEG) and distributed source localization technique. Thirty-three neurotypical subjects underwent the MEG recording during verb generation task, which was to produce verbs related to the presented noun cues...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28611513/brain-changes-detected-by-functional-magnetic-resonance-imaging-and-spectroscopy-in-patients-with-crohn-s-disease
#10
REVIEW
Kun Lv, Yi-Hong Fan, Li Xu, Mao-Sheng Xu
Crohn's disease (CD) is a chronic, non-specific granulomatous inflammatory disorder that commonly affects the small intestine and is a phenotype of inflammatory bowel disease (IBD). CD is prone to relapse, and its incidence displays a persistent increase in developing countries. However, the pathogenesis of CD is poorly understood, with some studies emphasizing the link between CD and the intestinal microbiota. Specifically, studies point to the brain-gut-enteric microbiota axis as a key player in the occurrence and development of CD...
May 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28610902/post-stimulus-fmri-and-eeg-responses-evidence-for-a-neuronal-origin-hypothesised-to-be-inhibitory
#11
K J Mullinger, M T Cherukara, R B Buxton, S T Francis, S D Mayhew
Post-stimulus undershoots, negative responses following cessation of stimulation, are widely observed in functional magnetic resonance (fMRI) blood oxygenation level dependent (BOLD) data. However, the debate surrounding whether the origin of this response phase is neuronal or vascular, and whether it provides functionally relevant information, that is additional to what is contained in the primary response, means that undershoots are widely overlooked. We simultaneously recorded electroencephalography (EEG), BOLD and cerebral blood-flow (CBF) [obtained from arterial spin labelled (ASL) fMRI] fMRI responses to hemifield checkerboard stimulation to test the potential neural origin of the fMRI post-stimulus undershoot...
June 10, 2017: NeuroImage
https://www.readbyqxmd.com/read/28607750/noninvasive-tongue-stimulation-combined-with-intensive-cognitive-and-physical-rehabilitation-induces-neuroplastic-changes-in-patients-with-multiple-sclerosis-a-multimodal-neuroimaging-study
#12
Gabriel Leonard, Yves Lapierre, Jen-Kai Chen, Rima Wardini, Joelle Crane, Alain Ptito
BACKGROUND: Multiple sclerosis (MS) patients have central nervous system (CNS) lesions that may impede cognitive and sensorimotor function. Few rehabilitative therapies are available. OBJECTIVES: The objective of this paper is to study effects of noninvasive tongue stimulation using the Portable Neuromodulation Stimulator (PoNS™) combined with intensive cognitive and physical rehabilitation on working memory, gait, balance and concomitant changes in the brain...
January 2017: Multiple Sclerosis Journal—Experimental, Translational and Clinical
https://www.readbyqxmd.com/read/28606387/the-effect-of-integration-masking-on-visual-processing-in-perceptual-categorization
#13
Sébastien Hélie
Learning to recognize and categorize objects is an essential cognitive skill allowing animals to function in the world. However, animals rarely have access to a canonical view of an object in an uncluttered environment. Hence, it is essential to study categorization under noisy, degraded conditions. In this article, we explore how the brain processes categorization stimuli in low signal-to-noise conditions using multivariate pattern analysis. We used an integration masking paradigm with mask opacity of 50%, 60%, and 70% inside a magnetic resonance imaging scanner...
August 2017: Brain and Cognition
https://www.readbyqxmd.com/read/28606245/prefrontal-brain-responsiveness-to-negative-stimuli-distinguishes-familial-risk-for-major-depression-from-acute-disorder
#14
Nils Opel, Ronny Redlich, Dominik Grotegerd, Katharina Dohm, Dario Zaremba, Susanne Meinert, Christian Bürger, Leonie Plümpe, Judith Alferink, Walter Heindel, Harald Kugel, Peter Zwanzger, Volker Arolt, Udo Dannlowski
BACKGROUND: Identifying reliable trait markers of familial risk for major depressive disorder (MDD) is a challenge in translational psychiatric research. In individuals with acute MDD, dysfunctional connectivity patterns of prefrontal areas have been shown repeatedly. However, it has been unclear in which neuronal networks functional alterations in individuals at familial risk for MDD might be present and to what extent they resemble findings previously reported in those with acute MDD...
June 12, 2017: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/28599130/negligible-interaction-of-ru-phen-3-2-with-human-serum-albumin-makes-it-promising-for-a-reliable-invivo-assessment-of-the-tissue-oxygenation
#15
Dominik Belej, Zuzana Jurasekova, Michal Nemergut, Georges Wagnieres, Daniel Jancura, Veronika Huntosova
The interaction between a ruthenium - based water soluble oxygen probe ([Ru(Phen)3](2+), phen - phenanthroline) and human serum albumin (HSA) was investigated with the aim of describing the influence of HSA on the [Ru(Phen)3](2+) luminescence properties. Nowadays, several oxygen sensitive luminescent probes are used to determine the oxygen level in different compartments of living organisms. However, they can interact, depending on their hydrophilic/hydrophobic characters, with various serum proteins, and/or lipids, during their utilization for invivo oxygen measurement...
May 31, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28598831/rat-red-blood-cell-storage-lesions-in-various-additive-solutions
#16
Vivek P Jani, Ozlem Yalcin, Alexander T Williams, Mark A Popovsky, Pedro Cabrales
BACKGROUND: Small rodent models are routinely used to evaluate the safety and efficacy of blood transfusions. Limited comprehensive literature exists about effect of different storage solutions in rat red blood cells (RBCs) characteristics. RBCs undergo time dependent biochemical and biophysical changes during storage known as hypothermic storage lesions (HSLs). OBJECTIVE: This study evaluates the effects of RBC additive solutions (AS) during storage of rat RBCs...
June 3, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28595784/cadmium-triggers-mitochondrial-oxidative-stress-in-human-peripheral-blood-lymphocytes-and-monocytes-analysis-using-in-vitro-and-system-toxicology-approaches
#17
Nouf Abdulkareem Omer Alkharashi, Vaiyapuri Subbarayan Periasamy, Jegan Athinarayanan, Ali A Alshatwi
Cadmium (Cd) is a well-known heavy metal that causes environmental pollution and human health problems. Several studies attempted to assess Cd toxicity in vitro and in vivo. However, the systemic profile of cadmium toxicity has not been studied well. In the present study, we assessed the toxicity of Cd on human peripheral blood lymphocytes and monocytes and gene expression, using a system toxicological approach. Cd effect on cell viability and morphology were analyzed by MTT assay and AO/EB staining respectively...
July 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/28594389/the-role-of-nox4-and-trx2-in-angiogenesis-and-their-potential-cross-talk
#18
REVIEW
Chaofei Chen, Li Li, Huanjiao Jenny Zhou, Wang Min
The nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) family is the major source of reactive oxygen species (ROS) in the vascular system. In this family, NOX4, a constitutive active form of NOXs, plays an important role in angiogenesis. Thioredoxin 2 (TRX2) is a key mitochondrial redox protein that maintains normal protein function and also provides electrons to peroxiredoxin 3 (PRX3) to scavenge H₂O₂ in mitochondria. Angiogenesis, a process of new blood vessel formation, is involved in a variety of physiological processes and pathological conditions...
June 8, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28588363/blood-oxygenation-level-dependent-functional-mri-of-early-evidences-of-brain-plasticity-after-hemodialysis-session-by-helixone-membrane-of-patients-with-indices-of-adrenal-deficiency
#19
Saïd Boujraf, Rachida Belaïch, Abdelkhalek Housni, Mustapha Maaroufi, Siham Tizniti, Tarik Sqalli, Mohammed Benzagmout
BACKGROUND: Various alterations of hypothalamic-pituitary-adrenal axis function have been described in patients with chronic renal failure. Nevertheless, controversial evidences were stated about the association between adrenal function deficiency (AD) and hemodialysis (HD). PURPOSE: The goal of this paper was to estimate indirect indices of the adrenal gland dysfunction which is potentially influenced by oxidative stress (OS) that still generates brain plasticity and reorganization of the functional control...
May 2017: Annals of Neurosciences
https://www.readbyqxmd.com/read/28586527/generation-of-the-membrane-potential-and-its-impact-on-the-motility-atp-production-and-growth-in-campylobacter-jejuni
#20
Anne-Xander van der Stel, Fred C Boogerd, Steven Huynh, Craig T Parker, Linda van Dijk, Jos P M van Putten, Marc M S M Wösten
The generation of a membrane potential (Δψ), the major constituent of the proton motive force (pmf), is crucial for ATP synthesis, transport of nutrients and flagellar rotation. Campylobacter jejuni harbors a branched electron transport chain, enabling respiration with different electron donors and acceptors. Here, we demonstrate that a relatively high Δψ is only generated in the presence of either formate as electron donor or oxygen as electron acceptor, in combination with an acceptor/donor, respectively...
June 6, 2017: Molecular Microbiology
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