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Juan Francisco Rodríguez-Landa, Jonathan Cueto-Escobedo, Luis Ángel Flores-Aguilar, Gilberto Uriel Rosas-Sánchez, María de Jesús Rovirosa-Hernández, Francisco García-Orduña, Miguel Carro-Juárez
BACKGROUND: Montanoa frutescens and Montanoa grandiflora have been indistinctly used for centuries in traditional Mexican medicine for reproductive impairments, anxiety, and mood disorders. Preclinical studies support their aphrodisiac and anxiolytic properties, but their effects on mood are still unexplored. METHODS: The effects of 25 and 50 mg/kg of M frutescens and M grandiflora extracts were evaluated on days 1, 7, 14, 21, and 28 of treatment, and compared with fluoxetine (1 mg/kg) and Remotiv (7...
January 2018: J Evid Based Integr Med
Hongbo Zheng, Lin Li, Bin Sun, Yun Gao, Wei Song, Xiaoyu Zhao, Yanhui Gao, Zhiyu Xie, Nianzhao Zhang, Jianbo Ji, Huiqing Yuan, Hongxiang Lou
Based on perlolyrine (1), a natural alkaloid with weak PDE5 potency from the traditional Chinese aphrodisiac plant Tribulus terrestris L., a series α-substituted tetrahydro-β-carboline (THβC) derivatives were synthesized via T+ BF4- -mediated oxidative C-H functionalization of N-aryl THβCs with diverse potassium trifluoroborates. Following Winterfeldt oxidation afforded the corresponding furyl/thienyl pyrroloquinolones, of which 5-ethylthiophene/ethylfuran derivatives 20a-b were identified as the most potent and selective PDE5 inhibitors...
February 16, 2018: European Journal of Medicinal Chemistry
Ajay Godwin Potnuri, Lingesh Allakonda, Mangala Lahkar
Chemotherapy induced testicular toxicity is an emerging reason for azoospermia and impotency in males. Cyclophosphamide (CP) is a widely used chemotherapeutic agent to manage neoplastic and non-neoplastic autoimmune diseases. Testicular toxicity along with bladder and hepatotoxicity are its widely reported adverse effects. Crocin (CR) is the digentiobiosyl ester of crocetin, found in the fruits of gardenia (Gardenia jasminoides E.) and dried stigmas of saffron (Crocus sativus L.) possess antioxidant, anti-depressant, anti-tumor and aphrodisiac properties...
February 24, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Hnin Ei Thu, Zahid Hussain, Isa Naina Mohamed, Ahmad Nazrun Shuid
BACKGROUND: Eurycoma longifolia (E. longifolia) has gained widespread recognition due to its versatile pharmacological activities including aphrodisiac, anticancer, antimicrobial, antioxidant, anti-inflammatory, anxiolytic, anti-diabetic, ergogenic, insecticidal, anti-rheumatism, bone protection, and anti-ulcer effects. OBJECTIVE: This review was aimed to critically overview the literature and summarizes the antibacterial, antiprotozoal, and antifungal trends of E...
February 19, 2018: Current Drug Targets
M T Yakubu, A R Atoyebi
The effects of aqueous extract of Brysocarpus coccineus roots (AEBCR) were studied on sexual behaviour and testicular function of paroxetine-induced sexual dysfunction (SD) in male rats. Ninety, sexually matured male rats (150.88 ± 5.53 g) were assigned into two groups: A and B. Fifteen SD animals from group B were each allotted to B1, B2, B3, B4 and B5 and received distilled water (DW), Powmax M (7.14 mg/kg body weight, b.w.) 50, 100 and 150 mg/kg b.w of AEBCR, respectively, for 7 days while the non-SD animals (group A) received DW...
February 22, 2018: Andrologia
Matin Ghaheri, Shahram Miraghaee, Atefeh Babaei, Bahareh Mohammadi, Danial Kahrizi, Zahra Minoosh Saivosh Haghighi, Gholamreza Bahrami
Stevia rebaudiana Bertoni has been used locally as a non-calorie sweetener in medicine and diabetic diet which claimed to have aphrodisiac properties, although no scientific data of this function have been reported. The aim of this study was to investigate the effect of S. rebaudiana extract on sexual dysfunction, testosterone levels and number of Leydig cells in Streptozotocin (STZ)-induced diabetic male rats. A total of 28 diabetic male rats were randomly divided into 4 groups: diabetic group without any extract and 3 extract groups (5, 50 and 100 mg/kg)...
February 10, 2018: Cellular and Molecular Biology
Gideon O Alade, Jones O Moody, Olanrewaju R Awotona, Saburi A Adesanya, Daowan Lai, Peter Proksch
AIM: To isolate the spermicidal constituents of Sacoglottis gabonensis. MATERIALS AND METHODS: The ethanolic extract with partitioned fractions of Sacoglottis gabonensis stem bark were subjected to sperm immobilization assay. The most active EtOAc fraction was further purifi ed by column and Semi-Preparative High Performance Liquid Chromatography to give compounds which were characterized by spectroscopic methods (UV, LC/MS, and NMR). The compound(s) was also tested for sperm immobilization activity...
December 20, 2017: Folia Medica
Sunil Kumar, Awantika Singh, Brijesh Kumar, Bikarma Singh, Lal Bahadur, Mohan Lal
A rapid, sensitive and reproducible method using ultra-high-performance liquid chromatography coupled with electrospray ionization hybrid triple quadrupole-linear ion trap mass spectrometry (UHPLC-ESI-QqQLIT-MS/MS) in multiple reaction monitoring (MRM) mode was developed and validated for simultaneous quantitation of anticancer (vincristine, vinblastine, vindesine), antihypertensive (ajmaline, ajmalicine, reserpine), aphrodisiac (yohimbine), sedative (serpentine) agents, dietary supplement (vinpocetine, yohimbine) and precursor of vinblastine (vindoline) from crude extracts of Catharanthus roseus...
December 25, 2017: Journal of Pharmaceutical and Biomedical Analysis
Clarice Flexa da Rocha, Yuri de Medeiros Souza Lima, Helison Oliveira Carvalho, Rodrigo Costa Pinto, Irlon Maciel Ferreira, Andres Navarrete Castro, Clarissa Silva Lima, José Carlos Tavares Carvalho
ETHNOPHARMACOLOGICAL RELEVANCE: The species Acmella oleracea (L.) R.K. Jansen (Asteraceae), popularly known as jambú, is marketed in fairs as a female aphrodisiac and has several pharmacological activities already confirmed, among them the sexual stimulant action. The objective of this study was to evaluate the effects of the oral administration of the hydroethanolic extract of A. oleracea flowers (EHAo) on wistar rats during the pre-mating, mating, and pre-implantation period. MATERIAL AND METHODS: During the treatment period, measurements of feed intake, water intake, weight, estrous cycle, behavior, reproductive parameters, biochemical parameters, hematological parameters, and histopathology of ovaries were performed daily...
March 25, 2018: Journal of Ethnopharmacology
Songül Karakaya, Sefa Gözcü, Zühal Güvenalp, Hilal Özbek, Hafize Yuca, Benan Dursunoğlu, Cavit Kazaz, Ceyda Sibel Kılıç
CONTEXT: Ferulago (Apiaceae) species have been used since ancient times for the treatment of intestinal worms, hemorrhoids, and as a tonic, digestive, aphrodisiac, or sedative, as well as in salads or as a spice due to their special odors. OBJECTIVES: This study reports the α-amylase and α-glucosidase inhibitory activities of dichloromethane extract and bioactive compounds isolated from Ferulago bracteata Boiss. & Hausskn. roots. MATERIALS AND METHODS: The isolated compounds obtained from dichloromethane extract of Ferulago bracteata roots through bioassay-guided fractionation and isolation process were evaluated for their in vitro α-amylase and α-glucosidase inhibitory activities at 5000-400 µg/mL concentrations...
December 2018: Pharmaceutical Biology
Xingli Tang, Opeyemi J Olatunji, Yifeng Zhou, Xilin Hou
BACKGROUND: Allium tuberosum is a well-known spice as well as a herb in traditional Chinese medicine, used for increasing libido and treating erectile dysfunction. However, not many studies have been done to evaluate the sexual enhancing properties of A. tuberosum. The aim of this study was to evaluate the aphrodisiac and vasorelaxant properties of A. tuberosum on corpus cavernosum smooth muscle (CCSM) as well as checking the effect on enhancing male rat sexual behavior, libido, potency as well as its spermatogenic properties...
December 1, 2017: BMC Complementary and Alternative Medicine
Benjamin Mutschlechner, Stefan Schwaiger, Thi Van Anh Tran, Hermann Stuppner
Aqueous extracts of the roots of Eurycoma longifolia are traditionally used to improve sexual performance, to treat infertility and other sexual dysfunctions but also to increase muscle strength. Nowadays, many different products are commercially available which are promoted as E. longifolia extracts and claim to possess beneficial aphrodisiac effects. Since such herbal aphrodisiac preparations have been recently the target of fraudulent product counterfeiting and because eurycomanone, one of the main quassinoids of E...
January 2018: Fitoterapia
Vanishri S Nayak, Nitesh Kumar, Antony S D'Souza, Sunil S Nayak, Sri P Cheruku, K Sreedhara Ranganath Pai
Stroke is considered to be one of the most important causes of death worldwide. Global ischemia causes widespread brain injury and infarctions in various regions of the brain. Oxidative stress can be considered an important factor in the development of tissue damage, which is caused because of arterial occlusion with subsequent reperfusion. Kapikacchu or Mucuna pruriens, commonly known as velvet bean, is well known for its aphrodisiac activities. It is also used in the treatment of snakebites, depressive neurosis, and Parkinson's disease...
December 13, 2017: Neuroreport
Sébastien Lebreton, Mikael A Carlsson, Peter Witzgall
Many animals adjust their reproductive behavior according to nutritional state and food availability. Drosophila females for instance decrease their sexual receptivity following starvation. Insulin signaling, which regulates many aspects of insect physiology and behavior, also affects reproduction in females. We show that insulin signaling is involved in the starvation-induced reduction in female receptivity. More specifically, females mutant for the insulin-like peptide 5 (dilp5) were less affected by starvation compared to the other dilp mutants and wild-type flies...
2017: Frontiers in Physiology
Olubukola Sinbad Olorunnisola, Olumide Samuel Fadahunsi, Peter Adegbola
Sphenocentrum jollyanum Pierre is a member of a diverse family of plants known as Menispermaceae. They are famous for a plethora of important biological functions. S. jollyanum is a shrub native to the tropical forest zones of West Africa and thrives in deep shade. It is widely cultivated in Cameroun, Sierra Leone, Nigeria, Ghana, and Côte d'Ivoire. S. jollyanum is employed in folk medicine as a cure for wounds, fever, coughs, high blood pressure, breast tumor, constipation, and as an aphrodisiac. Phytochemical investigations revealed that the plant is a rich source of secondary metabolites such as annin, alkaloids, saponins, and flavonoids...
July 3, 2017: Medicines (Basel, Switzerland)
Arielle Woznica, Joseph P Gerdt, Ryan E Hulett, Jon Clardy, Nicole King
We serendipitously discovered that the marine bacterium Vibrio fischeri induces sexual reproduction in one of the closest living relatives of animals, the choanoflagellate Salpingoeca rosetta. Although bacteria influence everything from nutrition and metabolism to cell biology and development in eukaryotes, bacterial regulation of eukaryotic mating was unexpected. Here, we show that a single V. fischeri protein, the previously uncharacterized EroS, fully recapitulates the aphrodisiac-like activity of live V...
September 7, 2017: Cell
Nguyen Huu Tung, Takuhiro Uto, Nguyen Thanh Hai, Gang Li, Yukihiro Shoyama
BACKGROUND: The roots of Eurycoma longifolia Jack have traditionally been used as an aphrodisiac tonic besides the other remedies for boils, fever, bleeding gums, and wound ulcer. Recently, the antiproliferative activity of E. longifolia has been reported and remained attractive to natural chemists. OBJECTIVE: The objective of this study was to study on antiproliferative compounds from the root of E. longifolia. MATERIALS AND METHODS: Column chromatography was used to separate individual compounds, spectroscopic data including nuclear magnetic resonances and mass spectrometry were analyzed to determine the chemical structure of the isolates and for biological testing, antiproliferative activity of compounds was tested on seven human cancer cell lines (KATO III, HCT-15, Colo205, HepG2, PC-3, Jurkat, HL-60) by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide method...
July 2017: Pharmacognosy Magazine
Riazul Haque Tuhin, Marium Begum, Sohanur Rahman, Rubaba Karim, Taslima Begum, Siraj Uddin Ahmed, Ronia Mostofa, Amir Hossain, Mohamed Abdel-Daim, Rayhana Begum
BACKGROUND: Euphorbia hirta linn., is a species of Euphorbiaceae family. They are known as asthma plant, barokhervi. The plant E. hirta is famous for its medicinal importance among the tribal population. It is a common practice to use the whole to heal wounds. Several pharmacological properties including antiseptic, anti-inflammatory, antidibetic, antispasmodic, antibacterial, antiviral, antifungal, anticonvulsant, nootropic, antifertility and aphrodisiac properties have already been reported for this plant...
August 24, 2017: BMC Complementary and Alternative Medicine
Amita Rai, Snehashis Das, Mallikarjuna Rao Chamallamudi, Krishnadas Nandakumar, Raghavendra Shetty, Meghna Gill, Suhani Sumalatha, Raviraj Devkar, Karthik Gourishetti, Nitesh Kumar
ETHNOPHARMACOLOGICAL RELEVANCE: Tamarindus indica is an ingredient in the traditional aphrodisiac formulations in Africa and India. It is also a widely used food ingredient in other tropical countries. AIM OF THE STUDY: The present study was aimed to evaluate the aphrodisiac potential and reproductive safety profile of aqueous extract of Tamarindus indica in male Wistar rats. MATERIALS AND METHODS: The aqueous extract was prepared by maceration of pulp followed by reduction of volume in rotavapor under heat followed by freeze drying...
August 19, 2017: Journal of Ethnopharmacology
Shruti Beharry, Michael Heinrich
ETHNOPHARMACOLOGICAL RELEVANCE: Maca - Lepidium meyenii Walp. has been cultivated and used by Andean people for over 1300-2000 years in Peru as food and medicine. Starting in the late 1990's it has developed into an important herbal medicine in China and is now cultivated there widely, too AIM OF STUDY: This study aims to provide an insight into the emergence of maca on the global market as an alternative remedy to treat reproductive health related problems in both men and women and to critically assess these health claims...
January 30, 2018: Journal of Ethnopharmacology
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