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https://www.readbyqxmd.com/read/29770464/chemically-characterised-extract-of-saraca-asoca-improves-the-sexual-function-in-male-wistar-rats
#1
M Gill, A Rai, M Kinra, S Sumalatha, C M Rao, S P Cheruku, R Devkar, N Kumar
In this study, methanolic extract of Saraca asoca bark was evaluated for its aphrodisiac potential using male and female Wistar albino rats. Male rats were dosed daily for 54 days at a dose of 100 mg/kg p.o. Sexual activity of male rats was assessed after 14, 28, 42 and 54 days of the study. Male rats were placed in a glass chamber lit with a dim red light (10W) followed by the introduction of sexually receptive female rats in a ratio of 1:1. Improvement in sexual behaviour of male rats was characterised by an increase in both mount frequency and intromission frequency and decrease or reduction in mount latency and intromission latency compared to normal control...
May 16, 2018: Andrologia
https://www.readbyqxmd.com/read/29739640/mimosa-pudica-protects-the-testes-against-cadmium-induced-inflammation-and-oligospermia-potential-benefits-in-treatment-of-heavy-metal-toxicity
#2
F M Onyije, M C Nwanze, G O Alade, T O Alade, O O Mgbere, C K Okpora
Cadmium is a known environmental and industrial pollutant with an enormous tissue disrupting potential. Mimosa pudica (M. pudica) is a creeping annual or perennial herb known to possess anti asthmatic, anti-epileptic, anti-tumour, anti-fertility, aphrodisiac, analgesic, anti-depressant, sedative, emetic properties and a strong radical scavenging activity. This research was aimed at investigating the ameliorative effects of M. pudica on cadmium-induced testicular damage in adult male Sprague Dawley rats. Twenty adult Sprague Dawley rats were employed in the study...
April 27, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/29736066/prevalence-and-correlates-of-sexual-dysfunction-in-male-patients-with-alcohol-dependence-syndrome-a-cross-sectional-study
#3
Deepak Koyilerian Prabhakaran, A Nisha, P Joseph Varghese
Background: Contrary to the popular belief concerning the aphrodisiac effects of alcohol, there exists scientific evidence which conclude on sexual dysfunction caused by chronic alcohol use. There is a dearth of studies from India. Aim: The aim is to estimate the prevalence and correlates of sexual dysfunction in alcohol-dependent patients and to explore the association between sexual dysfunction and various alcohol-related variables. Materials and Methods: The study employed a cross-sectional descriptive design and recruited 84 male patients admitted for de-addiction in a tertiary care center...
January 2018: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/29710522/phytochemical-and-cytotoxic-evaluation-of-medicago-monantha-in-vivo-protective-potential-in-rats
#4
Muhammad Kamran, Muhammad Rashid Khan, Hizb Ullah Khan, Mazhar Abbas, Munawar Iqbal, Arif Nazir
This research focuses on screening and evaluation of bioactive constituents in plants through pharmacological assays. In present study, we evaluated phytochemicals, cytotoxic activity, in vivo effect of M. monantha against CCl4 induced toxicity in cardiac and renal tissues and its aphrodisiac potential in rats. Shade dried plant was extracted with methanol. The phytochemical screening indicates the presence of flavonoids and alkaloids. Aphrodisiac study showed improved sexual desire; may be attributed to the presence of saponins that boosts the androgen level...
June 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29689767/effects-of-standardized-quassinoid-rich-eurycoma-longifolia-extract-in-a-rat-model-of-osteoporosis-due-to-testosterone-deficiency-a-densitometric-morphometric-and-biomechanical-study
#5
Putri Ayu Jayusman, Isa Naina Mohamed, Ekram Alias, Sulaiman Md Dom, Ahmad Nazrun Shuid
BACKGROUND: Eurycoma longifolia (EL) is a well-known aphrodisiac herb for men. Recently, the crude extract of EL was reported to possess anti-osteoporotic activities. OBJECTIVE: This study aims to determine the bone protective effects of the standardized quassinoid-rich EL extract in testosterone-deficient rat model. METHODS: Ninety-six intact male Sprague-Dawley rats were randomized into baseline, sham, orchidectomized, and chemically castrated groups...
April 18, 2018: Journal of X-ray Science and Technology
https://www.readbyqxmd.com/read/29670778/multiple-arterial-thrombosis-related-with-cantharidin-ingestion
#6
Zehra Narli Ozdemir, Ugur Sahin, Sinem Civriz Bozdag, Osman Ilhan
Inherited and/or acquired thrombophilic defects can result in venous or arterial thrombosis. This case report describes arterial thrombotic episodes triggered by the ingestion of an aphrodisiac remedy containing cantharidin in a 46-year-old female patient later discovered to be heterozygous for prothrombin G20210A mutation and seropositive for anti- β 2 glycoprotein-I (anti- β 2-GPI) antibodies of IgA isotype.
2018: Case Reports in Hematology
https://www.readbyqxmd.com/read/29658045/potential-of-borojoa-patinoi-cuatrecasas-water-extract-to-inhibit-nosocomial-antibiotic-resistant-bacteria-and-cancer-cell-proliferation-in-vitro
#7
Clemencia Chaves-López, Donatella Usai, Matthew Gavino Donadu, Annalisa Serio, Robert Tulio González-Mina, Maria Chiara Simeoni, Paola Molicotti, Stefania Zanetti, Antonio Pinna, Antonello Paparella
Borojó (Borojoa patinoi Cuatrec.) is a fruit used in Colombian traditional medicine with supposed antihypertensive, antitumoral, diuretic, healing, immunological, anti-inflammatory and aphrodisiac effects. To explore the relative merits in terms of biological activities of borojó aqueous extract (BAE), we investigated in vitro its antimicrobial activity on nosocomial pathogenic and multidrug resistant (MDR) strains of Pseudomonas aeruginosa (6), Staphylococcus aureus (1) and Candida species (6), as well as its cytotoxicity on human conjunctive Wong-Kilbourne derivative (WKD) cells and Caco-2 cells from heterogeneous human epithelial colorectal adenocarcinoma...
April 16, 2018: Food & Function
https://www.readbyqxmd.com/read/29604915/aphrodisiac-activity-of-an-aqueous-extract-of-wood-ear-mushroom-auricularia-polytricha-heterobasidiomycetes-in-male-rats
#8
Gaurav Gupta, Rakesh Kumar Sharma, Rajiv Dahiya, Anurag Mishra, Juhi Tiwari, Ganesh N Sharma, Sanjay Sharma, Kamal Dua
Auricularia polytricha is a popular mushroom found all over the world. In this study we considered the effect of an aqueous extract of A. polytricha (AEAP) on restoring sexual performance parameters to normal, evaluated by considering observations of sexual behavior. At 0, 6, 12, 18, and 24 days, the following parameters of sexual performance were identified before and throughout the observations: mount latency, intromission latency, ejaculation latency, mounting frequency, intromission frequency, ejaculation frequency, and postejaculatory interval...
2018: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/29597037/a-new-magnetic-nanodiamond-graphene-oxide-hybrid-fe-3-o-4-nd-go-material-for-pre-concentration-and-sensitive-determination-of-sildenafil-in-alleged-herbal-aphrodisiacs-by-hplc-dad-system
#9
Erkan Yilmaz, Halil İbrahim Ulusoy, Özge Demir, Mustafa Soylak
A sensitive analytical methodology was investigated to concentrate and determine of sildenafil citrate (SLC) present at trace level in herbal supplementary products. The proposed method is based on simple and sensitive pre-concentration of SLC by using magnetic solid phase extraction with new developed magnetic nanodiamond/graphene oxide hybrid (Fe3 O4 @ND@GO) material as a sorbent. Experimental variables affecting the extraction efficiency of SLC like; pH, sample volume, eluent type and volume, extraction time and amount of adsorbent were studied and optimized in detail...
March 15, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29540064/the-aqueous-crude-extracts-of-montanoa-frutescens-and-montanoa-grandiflora-reduce-immobility-faster-than-fluoxetine-through-gaba-a-receptors-in-rats-forced-to-swim
#10
Juan Francisco Rodríguez-Landa, Jonathan Cueto-Escobedo, Luis Ángel Flores-Aguilar, Gilberto Uriel Rosas-Sánchez, María de Jesús Rovirosa-Hernández, Francisco García-Orduña, Miguel Carro-Juárez
BACKGROUND: Montanoa frutescens and Montanoa grandiflora have been indistinctly used for centuries in traditional Mexican medicine for reproductive impairments, anxiety, and mood disorders. Preclinical studies support their aphrodisiac and anxiolytic properties, but their effects on mood are still unexplored. METHODS: The effects of 25 and 50 mg/kg of M frutescens and M grandiflora extracts were evaluated on days 1, 7, 14, 21, and 28 of treatment, and compared with fluoxetine (1 mg/kg) and Remotiv (7...
January 2018: Journal of evidence-based integrative medicine
https://www.readbyqxmd.com/read/29505934/design-and-synthesis-of-furyl-thineyl-pyrroloquinolones-based-on-natural-alkaloid-perlolyrine-lead-to-the-discovery-of-potent-and-selective-pde5-inhibitors
#11
Hongbo Zheng, Lin Li, Bin Sun, Yun Gao, Wei Song, Xiaoyu Zhao, Yanhui Gao, Zhiyu Xie, Nianzhao Zhang, Jianbo Ji, Huiqing Yuan, Hongxiang Lou
Based on perlolyrine (1), a natural alkaloid with weak PDE5 potency from the traditional Chinese aphrodisiac plant Tribulus terrestris L., a series α-substituted tetrahydro-β-carboline (THβC) derivatives were synthesized via T+ BF4- -mediated oxidative C-H functionalization of N-aryl THβCs with diverse potassium trifluoroborates. Following Winterfeldt oxidation afforded the corresponding furyl/thienyl pyrroloquinolones, of which 5-ethylthiophene/ethylfuran derivatives 20a-b were identified as the most potent and selective PDE5 inhibitors...
April 25, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29486335/crocin-attenuates-cyclophosphamide-induced-testicular-toxicity-by-preserving-glutathione-redox-system
#12
Ajay Godwin Potnuri, Lingesh Allakonda, Mangala Lahkar
Chemotherapy induced testicular toxicity is an emerging reason for azoospermia and impotency in males. Cyclophosphamide (CP) is a widely used chemotherapeutic agent to manage neoplastic and non-neoplastic autoimmune diseases. Testicular toxicity along with bladder and hepatotoxicity are its widely reported adverse effects. Crocin (CR) is the digentiobiosyl ester of crocetin, found in the fruits of gardenia (Gardenia jasminoides E.) and dried stigmas of saffron (Crocus sativus L.) possess antioxidant, anti-depressant, anti-tumor and aphrodisiac properties...
May 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29468964/recent-advances-in-antibacterial-antiprotozoal-and-antifungal-trends-of-eurycoma-longifolia-a-review-of-therapeutic-implications-and-future-prospects
#13
Hnin Ei Thu, Zahid Hussain, Isa Naina Mohamed, Ahmad Nazrun Shuid
BACKGROUND: Eurycoma longifolia (E. longifolia) has gained widespread recognition due to its versatile pharmacological activities including aphrodisiac, anticancer, antimicrobial, antioxidant, anti-inflammatory, anxiolytic, anti-diabetic, ergogenic, insecticidal, anti-rheumatism, bone protection, and anti-ulcer effects. OBJECTIVE: This review was aimed to critically overview the literature and summarizes the antibacterial, antiprotozoal, and antifungal trends of E...
February 19, 2018: Current Drug Targets
https://www.readbyqxmd.com/read/29468717/brysocarpus-coccineus-schum-thonn-root-reinstates-sexual-competence-and-testicular-function-in-paroxetine-induced-sexual-dysfunction-in-male-wistar-rats
#14
M T Yakubu, A R Atoyebi
The effects of aqueous extract of Brysocarpus coccineus roots (AEBCR) were studied on sexual behaviour and testicular function of paroxetine-induced sexual dysfunction (SD) in male rats. Ninety, sexually matured male rats (150.88 ± 5.53 g) were assigned into two groups: A and B. Fifteen SD animals from group B were each allotted to B1, B2, B3, B4 and B5 and received distilled water (DW), Powmax M (7.14 mg/kg body weight, b.w.) 50, 100 and 150 mg/kg b.w of AEBCR, respectively, for 7 days while the non-SD animals (group A) received DW...
February 22, 2018: Andrologia
https://www.readbyqxmd.com/read/29433621/effect-of-stevia-rebaudiana-bertoni-extract-on-sexual-dysfunction-in-streptozotocin-induced-diabetic-male-rats
#15
Matin Ghaheri, Shahram Miraghaee, Atefeh Babaei, Bahareh Mohammadi, Danial Kahrizi, Zahra Minoosh Saivosh Haghighi, Gholamreza Bahrami
Stevia rebaudiana Bertoni has been used locally as a non-calorie sweetener in medicine and diabetic diet which claimed to have aphrodisiac properties, although no scientific data of this function have been reported. The aim of this study was to investigate the effect of S. rebaudiana extract on sexual dysfunction, testosterone levels and number of Leydig cells in Streptozotocin (STZ)-induced diabetic male rats. A total of 28 diabetic male rats were randomly divided into 4 groups: diabetic group without any extract and 3 extract groups (5, 50 and 100 mg/kg)...
February 10, 2018: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29341951/spermicidal-constituents-of-ethanolic-extract-of-sacoglottis-gabonensis-stem-bark
#16
Gideon O Alade, Jones O Moody, Olanrewaju R Awotona, Saburi A Adesanya, Daowan Lai, Peter Proksch
AIM: To isolate the spermicidal constituents of Sacoglottis gabonensis. MATERIALS AND METHODS: The ethanolic extract with partitioned fractions of Sacoglottis gabonensis stem bark were subjected to sperm immobilization assay. The most active EtOAc fraction was further purifi ed by column and Semi-Preparative High Performance Liquid Chromatography to give compounds which were characterized by spectroscopic methods (UV, LC/MS, and NMR). The compound(s) was also tested for sperm immobilization activity...
December 20, 2017: Folia Medica
https://www.readbyqxmd.com/read/29304410/simultaneous-quantitative-determination-of-bioactive-terpene-indole-alkaloids-in-ethanolic-extracts-of-catharanthus-roseus-l-g-don-by-ultra-high-performance-liquid-chromatography-tandem-mass-spectrometry
#17
Sunil Kumar, Awantika Singh, Brijesh Kumar, Bikarma Singh, Lal Bahadur, Mohan Lal
A rapid, sensitive and reproducible method using ultra-high-performance liquid chromatography coupled with electrospray ionization hybrid triple quadrupole-linear ion trap mass spectrometry (UHPLC-ESI-QqQLIT -MS/MS) in multiple reaction monitoring (MRM) mode was developed and validated for simultaneous quantitation of anticancer (vincristine, vinblastine, vindesine), antihypertensive (ajmaline, ajmalicine, reserpine), aphrodisiac (yohimbine), sedative (serpentine) agents, dietary supplement (vinpocetine, yohimbine) and precursor of vinblastine (vindoline) from crude extracts of Catharanthus roseus...
March 20, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29273437/action-of-the-hydroethanolic-extract-of-the-flowers-of-acmella-oleracea-l-r-k-jansen-on-the-reproductive-performance-of-wistar-females-rats-a-popular-female-aphrodisiac-from-the-amazon
#18
Clarice Flexa da Rocha, Yuri de Medeiros Souza Lima, Helison Oliveira Carvalho, Rodrigo Costa Pinto, Irlon Maciel Ferreira, Andres Navarrete Castro, Clarissa Silva Lima, José Carlos Tavares Carvalho
ETHNOPHARMACOLOGICAL RELEVANCE: The species Acmella oleracea (L.) R.K. Jansen (Asteraceae), popularly known as jambú, is marketed in fairs as a female aphrodisiac and has several pharmacological activities already confirmed, among them the sexual stimulant action. The objective of this study was to evaluate the effects of the oral administration of the hydroethanolic extract of A. oleracea flowers (EHAo) on wistar rats during the pre-mating, mating, and pre-implantation period. MATERIAL AND METHODS: During the treatment period, measurements of feed intake, water intake, weight, estrous cycle, behavior, reproductive parameters, biochemical parameters, hematological parameters, and histopathology of ovaries were performed daily...
March 25, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29233045/the-%C3%AE-amylase-and-%C3%AE-glucosidase-inhibitory-activities-of-the-dichloromethane-extracts-and-constituents-of-ferulago-bracteata-roots
#19
Songül Karakaya, Sefa Gözcü, Zühal Güvenalp, Hilal Özbek, Hafize Yuca, Benan Dursunoğlu, Cavit Kazaz, Ceyda Sibel Kılıç
CONTEXT: Ferulago (Apiaceae) species have been used since ancient times for the treatment of intestinal worms, hemorrhoids, and as a tonic, digestive, aphrodisiac, or sedative, as well as in salads or as a spice due to their special odors. OBJECTIVES: This study reports the α-amylase and α-glucosidase inhibitory activities of dichloromethane extract and bioactive compounds isolated from Ferulago bracteata Boiss. & Hausskn. roots. MATERIALS AND METHODS: The isolated compounds obtained from dichloromethane extract of Ferulago bracteata roots through bioassay-guided fractionation and isolation process were evaluated for their in vitro α-amylase and α-glucosidase inhibitory activities at 5000-400 µg/mL concentrations...
December 2018: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29191197/in-vitro-and-in-vivo-aphrodisiac-properties-of-the-seed-extract-from-allium-tuberosum-on-corpus-cavernosum-smooth-muscle-relaxation-and-sexual-behavior-parameters-in-male-wistar-rats
#20
Xingli Tang, Opeyemi J Olatunji, Yifeng Zhou, Xilin Hou
BACKGROUND: Allium tuberosum is a well-known spice as well as a herb in traditional Chinese medicine, used for increasing libido and treating erectile dysfunction. However, not many studies have been done to evaluate the sexual enhancing properties of A. tuberosum. The aim of this study was to evaluate the aphrodisiac and vasorelaxant properties of A. tuberosum on corpus cavernosum smooth muscle (CCSM) as well as checking the effect on enhancing male rat sexual behavior, libido, potency as well as its spermatogenic properties...
December 1, 2017: BMC Complementary and Alternative Medicine
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