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Choroidal nevus

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https://www.readbyqxmd.com/read/27911450/uveal-melanoma-relatively-rare-but-deadly-cancer
#1
REVIEW
S Kaliki, C L Shields
Although it is a relatively rare disease, primarily found in the Caucasian population, uveal melanoma is the most common primary intraocular tumor in adults with a mean age-adjusted incidence of 5.1 cases per million per year. Tumors are located either in iris (4%), ciliary body (6%), or choroid (90%). The host susceptibility factors for uveal melanoma include fair skin, light eye color, inability to tan, ocular or oculodermal melanocytosis, cutaneous or iris or choroidal nevus, and BRCA1-associated protein 1 mutation...
December 2, 2016: Eye
https://www.readbyqxmd.com/read/27843235/flat-choroidal-melanoma-masquerading-as-central-serous-chorioretinopathy
#2
Timothy Patrick Higgins, Chloe T L Khoo, George Magrath, Carol L Shields
There are several mimickers of choroidal melanoma. We report a patient with recent family stress who developed blurred vision to 20/50 OD and was found to have unilateral central serous chorioretinopathy and a coincidental choroidal nevus. After 1 year without resolution of the subretinal fluid, the patient was referred for our opinion. On examination, visual acuity was 20/50 in the right eye and 20/20 in the left eye. The left eye was normal. Evaluation of the right eye showed a small, pigmented submacular choroidal lesion measuring 4 mm × 3 mm...
September 2016: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/27711926/photoreceptor-arrangement-changes-secondary-to-choroidal-nevus
#3
Murilo W Rodrigues, Zelia M Correa, Emil A Say, Felipe P Borges, Rubens Camargo Siqueira, José Augusto Cardillo, Rodrigo Jorge
Importance: Although mostly asymptomatic, patients with choroidal nevi carry a moderate risk for malignant transformation and visual loss. A novel noninvasive imaging assessment could change the current clinical evaluation of choroidal nevi. Observation: Three patients with a recent diagnosis of choroidal nevi underwent a novel adaptive optical assessment that detected potential photoreceptor abnormalities in the retina overlying the choroidal nevi. Conclusions and Relevance: Adaptive optics imaging may provide high-resolution en face images of retinal structural changes in the photoreceptor mosaic overlying the choroidal nevi...
October 6, 2016: JAMA Ophthalmology
https://www.readbyqxmd.com/read/27521666/swept-source-optical-coherence-tomography-of-choroidal-nevi
#4
Zofia Michalewska, Janusz Michalewski, Jerzy Nawrocki
OBJECTIVE: The aim of this article is to report on retinal and choroidal morphology in choroidal nevi documented with Swept Source optical coherence tomography (SS-OCT). DESIGN: This is a retrospective, observational study. PARTICIPANTS: We included 27 consecutive patients with choroidal nevi. Mean age was 66.3 years (21-95 years). METHODS: The SS-OCT scanning protocol consisted of a single line scan through the centre of the nevi with a resolution of 3 µm, built from 1024 A-scans, with a length of 12 mm...
August 2016: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/27437999/differential-macular-features-on-optical-coherence-tomography-angiography-in-eyes-with-choroidal-nevus-and-melanoma
#5
Alicia Valverde-Megías, Emil A T Say, Sandor R Ferenczy, Carol L Shields
PURPOSE: To evaluate optical coherence tomography angiography (OCTA) characteristics of macular vascular details in eyes with choroidal nevus and melanoma, compared with unaffected contralateral eye. METHODS: Retrospective comparative analysis comprising 70 patients with choroidal nevus and 36 patients with choroidal melanoma examined with optical coherence tomography angiography. Measurements included central macular thickness (CMT), superficial (sFAZ) and deep (dFAZ) foveal avascular zone (FAZ) area, and superficial (sCVD) and deep (dCVD) capillary vascular density (CVD)...
July 19, 2016: Retina
https://www.readbyqxmd.com/read/27433882/photodynamic-therapy-for-choroidal-nevus-with-subfoveal-fluid-in-15-cases
#6
Renelle Pointdujour-Lim, Arman Mashayekhi, Jerry A Shields, Carol L Shields
PURPOSE: To report the efficacy of photodynamic therapy (PDT) for management of choroidal nevus associated with subfoveal fluid. METHODS: A retrospective chart review of 15 patients with choroidal nevus and associated subfoveal fluid treated with PDT was performed. Standard-fluence PDT was used in all patients and response to treatment was assessed with optical coherence tomography. RESULTS: Complete resolution of subfoveal fluid was achieved in 9 eyes (60%) and partial resolution in 4 eyes (27%); 1 eye (7%) experienced worsening subfoveal fluid, and 1 eye (7%) was stable after PDT...
July 18, 2016: Retina
https://www.readbyqxmd.com/read/27171585/bilateral-diffuse-uveal-melanocytic-proliferation-presenting-as-a-giant-unilateral-choroidal-nevus-a-case-report
#7
Carlos Menezes, Rui Carvalho, Joana Neves-Martins, Carla Teixeira
BACKGROUND/AIMS: The aim of our study was to report a case of bilateral diffuse uveal melanocytic proliferation (BDUMP) with a markedly asymmetric presentation and fundoscopic response to palliative chemotherapy. CASE REPORT: We report a 67-year-old Caucasian man who presented with vision loss in his right eye. The best-corrected visual acuities were 2/10 in the right eye and 10/10 in the left eye, and biomicroscopy revealed bilateral mild cataracts. Fundoscopy of the right eye showed a macular flat and pigmented lesion extending beyond the posterior pole with areas of giraffe-type pigmentation and an overlying exudative retinal detachment...
September 2015: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/27096381/malignant-transformation-of-a-choroidal-nevus-in-an-eye-treated-for-choroidal-melanoma
#8
Ido D Fabian, Amit K Arora, Victoria M L Cohen
PURPOSE: To report a case of a choroidal melanoma and a discrete choroidal nevus that has transformed into a malignant melanoma 5 years after initial diagnosis. METHODS: Retrospective case report. RESULTS: A diffuse macular choroidal melanoma and a discrete choroidal nevus located superonasal to the optic disk were diagnosed in the right eye of a 63-year-old woman in 2009. The patient was treated by ruthenium plaque radiotherapy for the choroidal melanoma, which consequently flattened and scarred...
April 19, 2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/26963960/diffuse-peripapillary-choroidal-melanoma-that-evolved-from-a-small-presumed-choroidal-nevus-successfully-treated-with-gamma-knife-radiotherapy
#9
Jacob S Duker, Jay S Duker
PURPOSE: To report a case of diffuse peripapillary choroidal melanoma which began as a small choroidal nevus and was successfully treated with gamma knife radiotherapy. METHODS: Observational case report. RESULTS: A 31-year-old visually asymptomatic man presented for a routine eye examination and was noted to have a small choroidal nevus. Six years later, the lesion had become a diffuse juxtapapillary choroidal melanoma with a thickness of 1...
October 2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/26630661/serum-adiponectin-insulin-resistance-and-uveal-melanoma-clinicopathological-correlations
#10
Duygu G Sevim, Hayyam Kiratli
To investigate the status of insulin resistance, metabolic syndrome, dyslipidemia, and serum adiponectin levels in patients with uveal melanoma and choroidal nevus were investigated. Our study included 86 patients with uveal melanoma, 38 patients with choroidal nevus, and 86 controls. Uveal melanomas were classified as small, medium, and large on the basis of Collaborative Ocular Melanoma Study (COMS) criteria. Patients with uveal melanoma had significantly higher homeostatic model assessment scores compared with patients with choroidal nevus (P<0...
April 2016: Melanoma Research
https://www.readbyqxmd.com/read/26599253/spectral-domain-optical-coherence-tomography-of-polypoidal-choroidal-vasculopathy-associated-with-benign-choroidal-nevus
#11
Gabriella De Salvo, Sara Vaz-Pereira, Kulwant S Sehmi, Richard M Andrews, Mandeep S Sagoo
Two cases of polypoidal choroidal vasculopathy (PCV) complicating benign choroidal nevus and their tomographic features at spectral-domain optical coherence tomography (SD-OCT) are reported. Two eyes with choroidal nevus and associated subretinal fluid underwent complete ophthalmological examination, SD-OCT, fundus fluorescein angiography, and indocyanine green angiography (ICGA). SD-OCT and ICGA confirmed the diagnosis of PCV in both cases. Ophthalmologists should be aware of this rare combination between choroidal nevus and PCV...
November 2015: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/26595609/sex-differences-in-the-relationship-between-obesity-and-choroidal-nevus-in-us-adults
#12
Rebecca M Sieburth, Mary Qiu, Carol L Shields
PURPOSE: To investigate sex differences and the effect of other variables on the association between obesity and choroidal nevus in the US adult population. METHODS: The study population of this cross-sectional study included 5575 subjects aged ≥40 years from the 2005 to 2008 National Health and Nutrition Examination Survey (NHANES) who underwent retinal imaging. Primary predictor variables were body mass index (BMI) when the subject was 25 years old ("former BMI") and BMI at time of NHANES participation ("current BMI")...
November 2015: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/26509999/polypoidal-choroidal-vasculopathy-secondary-to-a-stable-choroidal-nevus
#13
James G Wong, Xin Jie Lai, Richard Y Sarafian, Hon Seng Wong, Jeremy B Smith
PURPOSE: Choroidal nevus is the most common ocular fundus tumor in adults. Previous studies have widely discussed the features of choroidal neovascularization secondary to nevus and its treatment options. Polypoidal choroidal vasculopathy (PCV) is an exudative chorioretinopathy that is often underdiagnosed. Clinical features, natural history, and treatment response of PCV are distinct from occult choroidal neovascularization. Polypoidal choroidal vasculopathy secondary to choroidal nevus has not been previously documented...
2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/26402791/relationship-between-female-reproductive-factors-and-choroidal-nevus-in-us-women-analysis-of-data-from-the-2005-2008-national-health-and-nutrition-examination-survey
#14
Mary Qiu, Carol L Shields
IMPORTANCE: Choroidal nevus is a precursor for uveal melanoma and there are no known risk factors besides white race. Female sex hormones have been hypothesized to play a role in the pathogenesis of uveal melanoma. OBJECTIVE: To explore the association between female reproductive factors and choroidal nevus in the US adult female population. DESIGN, SETTING, AND PARTICIPANTS: Cross-sectional, population-based study of 2505 US women aged 40 years or older from the 2005-2008 National Health and Nutrition Examination Survey...
November 2015: JAMA Ophthalmology
https://www.readbyqxmd.com/read/26383622/detection-of-circulating-melanoma-cells-in-choroidal-melanocytic-lesions
#15
Manuel F Bande, Maria Santiago, Laura Muinelo-Romay, Maria Jose Blanco, Purificacion Mera, Carmela Capeans, Maria Pardo, Antonio Piñeiro
PURPOSE: To detect and quantify circulating tumour cells (CTCs) in peripheral blood of patients with uveal melanoma primary non-metastatic tumours, and to analyze the possible relationship between CTCs and clinical risk factors. METHODS: Prospective study with two clinical groups: 4 patients diagnosed with choroidal nevus and 8 patients with choroidal melanoma prior to treatment. A single sample of 7.5 mL of peripheral blood was taken and the CTCs were isolated using a CellSearch system that captures positive cells for the CD146 antigen (MUC18)...
2015: BMC Research Notes
https://www.readbyqxmd.com/read/26277063/congenital-uveal-melanoma
#16
REVIEW
Arun D Singh, Lynn A Schoenfield, Boris C Bastian, Hassan A Aziz, Meghan J Marino, Charles V Biscotti
A 3-month-old infant with a white mother and Asian father presented with discoloration and prominence of the left eye since birth. Examination revealed a normal right eye. The left eye had hyperchromic heterochromia and an enlarged cornea (diameter, 13.0 mm) with intraocular pressure of 26 mm Hg. There were multiple areas of subconjunctival nodular pigmentation that extended posteriorly into the superior fornix. Fundus examination showed a large ciliochoroidal pigmented mass extending from 10:30 to 3:00 o'clock position involving the superior half of the choroid and adjacent ciliary body...
January 2016: Survey of Ophthalmology
https://www.readbyqxmd.com/read/26270411/posterior-scleral-bowing-with-choroidal-nevus-on-enhanced-depth-imaging-optical-coherence-tomography
#17
Rosa Dolz-Marco, Murat Hasanreisoglu, Jerry A Shields, Carol L Shields
IMPORTANCE: Recognition of posterior scleral bowing with choroidal nevus is essential to avoid an underestimation of tumor thickness. OBJECTIVE: To describe a particular observation of posterior scleral bowing associated with choroidal nevus on enhanced-depth imaging (EDI) optical coherence tomography (OCT). DESIGN, SETTING, AND PARTICIPANTS: Retrospective observational case series at a referral center involving 17 eyes of 17 patients. Patients were seen from June 2013 to July 2014, with all data collected and analyzed from June 2014 to July 2014...
October 2015: JAMA Ophthalmology
https://www.readbyqxmd.com/read/26255109/choroidal-nevus-in-the-united-states-adult-population-racial-disparities-and-associated-factors-in-the-national-health-and-nutrition-examination-survey
#18
Mary Qiu, Carol L Shields
PURPOSE: To describe the prevalence of choroidal nevus in the US population and identify possible associated factors. DESIGN: Cross-sectional study. PARTICIPANTS: A total of 5575 participants aged ≥40 years from the 2005-2008 National Health and Nutrition Examination Survey (NHANES) who underwent retinal imaging examination. METHODS: Predictor variables included a spectrum of demographic, ophthalmic, dermatologic, systemic, socioeconomic, or occupational factor variables available in NHANES...
October 2015: Ophthalmology
https://www.readbyqxmd.com/read/26131807/phakomatosis-pigmentovascularis-associated-with-sturge-weber-syndrome-ota-nevus-and-congenital-glaucoma
#19
Yangfan Yang, Xiujuan Guo, Jiangang Xu, Yiming Ye, Xiaoan Liu, Minbin Yu
Phakomatosis pigmentovascularis (PPV) is a rare congenital malformation syndrome that is characterized by a combination of capillary abnormalities and dermal melanocytosis.We describe 3 cases of PPV combined with bilateral Sturge-Weber syndrome (SWS), Ota nevus, and congenital glaucoma.Case 1 was a 2-year-old boy. Facial port-wine stains distributed along the 3 branches of his trigeminal nerves, which suggested the existence of SWS. Gray-blue patches were spread over the frontal and temporal areas of bilateral face, waist, buttocks, and thigh...
July 2015: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26064732/bilateral-sturge-weber-and-phakomatosis-pigmentovascularis-with-glaucoma-an-overlap-syndrome
#20
Bharat Patil, Gautam Sinha, Bhagabat Nayak, Reetika Sharma, Sadhana Kumari, Tanuj Dada
UNLABELLED: Aim. To report a case of bilateral Sturge-Weber and Phakomatosis pigmentovascularis with secondary glaucoma in a child. Method. CASE REPORT: Results. A 4-year-old male child was referred to us for control of intraocular pressure (IOP). Sleeping IOP was 36 mm Hg in right eye and 28 mm Hg in the left eye. The sclera of both the eyes showed bluish black pigmentation-melanosis bulbi. Fundus examination of both eyes showed diffuse choroidal hemangiomas with glaucomatous cupping...
2015: Case Reports in Ophthalmological Medicine
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