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Choroidal nevus

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https://www.readbyqxmd.com/read/28243154/photodynamic-therapy-for-polypoidal-choroidal-vasculopathy-secondary-to-choroidal-nevus
#1
James G Wong, Xin Jie Lai, Richard Y Sarafian, Hon Seng Wong, Jeremy B Smith
We report a case of a Caucasian female who developed active polypoidal choroidal vasculopathy (PCV) at the edge of a stable choroidal nevus and was successfully treated with verteporfin photodynamic therapy. No active polyp was detectable on indocyanine green angiography 2 years after treatment, and good vision was maintained. Indocyanine green angiography is a useful investigation to diagnose PCV and may be underutilized. Unlike treatment of choroidal neovascularization secondary to choroidal nevus, management of PCV secondary to nevus may not require intravitreal anti-vascular endothelial growth factor therapy...
2017: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/28210186/bilateral-retinitis-pigmentosa-with-unilateral-choroidal-nevus-a-hitherto-unreported-association
#2
Rupak Roy, Kumar Saurabh, Debmalya Das, Preeti Sharma, Avirupa Ghose, Dhileesh P Chandrasekharan
Retinitis Pigmentosa (RP) has been reported to be associated with retinal hemangioma, retinal angiomatous proliferation, polypoidal choroidal vasculopathy and vasoproliferative tumours. However there is no previous report of choroidal nevus in an eye with RP. We describe such a case in which the eye with RP had a choroidal nevus at the macula. The coexistence of these two entities in the same eye emphasizes the need of careful examination of patients with RP. The presence of choroidal nevus warrants additional investigations such as B scan ultrasonography and a close follow-up to pick up changes in the nevus size and morphology...
July 2016: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/28141766/choroidal-nevus-a-review-of-prevalence-features-genetics-risks-and-outcomes
#3
Jason L Chien, Kareem Sioufi, Thamolwan Surakiatchanukul, Jerry A Shields, Carol L Shields
PURPOSE OF REVIEW: To review the prevalence, clinical features, imaging findings, cytogenetics, and risks and outcomes of choroidal nevus. RECENT FINDINGS: Choroidal nevus is a benign melanocytic tumor, often discovered incidentally on ophthalmic examination. This lesion is generally well circumscribed and pigmented. The prevalence of choroidal nevus in postequatorial region in United States adults (≥40 years old) is approximately 5%. Choroidal nevus is associated with higher lifetime unopposed estrogen and greater BMI...
January 30, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28064423/pathophysiology-diagnosis-and-management-of-glaucoma-associated-with-sturge-weber-syndrome
#4
REVIEW
Usman Javaid, Muhammad Hassaan Ali, Samreen Jamal, Nadeem Hafeez Butt
PURPOSE: Sturge-Weber syndrome (SWS), also known as encephalotrigeminal angiomatosis, is a condition which includes leptomeningeal hemangioma, facial angiomatosis or nevus flammeus, and ocular changes. SWS can lead to severe complications of anterior segment involving conjunctiva and eyelids, whereas posterior segment of the eye may also be affected by diffuse choroidal hemorrhages. This article was written with the objectives to determine the pathophysiology, diagnosis, and treatment of glaucoma associated with this rare and challenging disorder...
January 7, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28009412/optical-coherence-tomography-angiography-of-polypoidal-neovascularization-associated-with-choroidal-nevus
#5
Maria Vittoria Cicinelli, Lorenzo Iuliano, Alessandro Rabiolo, Alessandro Marchese, Giuseppe Querques, Francesco Bandello
PURPOSE: To report a case of juxtapapillary polypoidal choroidal neovascularization (PCNV) associated with choroidal nevus investigated by means of optical coherence tomography angiography (OCT-A). METHODS: Case report. RESULTS: A 72-year-old woman presented with visual loss and metamorphopsia in her left eye for 5 days secondary to PCNV that developed on the border of a juxtapapillary choroidal nevus. Fluorescein angiography, indocyanine green angiography, and spectral-domain OCT confirmed the diagnosis...
November 28, 2016: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/27911450/uveal-melanoma-relatively-rare-but-deadly-cancer
#6
REVIEW
S Kaliki, C L Shields
Although it is a relatively rare disease, primarily found in the Caucasian population, uveal melanoma is the most common primary intraocular tumor in adults with a mean age-adjusted incidence of 5.1 cases per million per year. Tumors are located either in iris (4%), ciliary body (6%), or choroid (90%). The host susceptibility factors for uveal melanoma include fair skin, light eye color, inability to tan, ocular or oculodermal melanocytosis, cutaneous or iris or choroidal nevus, and BRCA1-associated protein 1 mutation...
February 2017: Eye
https://www.readbyqxmd.com/read/27843235/flat-choroidal-melanoma-masquerading-as-central-serous-chorioretinopathy
#7
Timothy Patrick Higgins, Chloe T L Khoo, George Magrath, Carol L Shields
There are several mimickers of choroidal melanoma. We report a patient with recent family stress who developed blurred vision to 20/50 OD and was found to have unilateral central serous chorioretinopathy and a coincidental choroidal nevus. After 1 year without resolution of the subretinal fluid, the patient was referred for our opinion. On examination, visual acuity was 20/50 in the right eye and 20/20 in the left eye. The left eye was normal. Evaluation of the right eye showed a small, pigmented submacular choroidal lesion measuring 4 mm × 3 mm...
September 2016: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/27711926/photoreceptor-arrangement-changes-secondary-to-choroidal-nevus
#8
Murilo W Rodrigues, Zelia M Correa, Emil A Say, Felipe P Borges, Rubens Camargo Siqueira, José Augusto Cardillo, Rodrigo Jorge
Importance: Although mostly asymptomatic, patients with choroidal nevi carry a moderate risk for malignant transformation and visual loss. A novel noninvasive imaging assessment could change the current clinical evaluation of choroidal nevi. Observation: Three patients with a recent diagnosis of choroidal nevi underwent a novel adaptive optical assessment that detected potential photoreceptor abnormalities in the retina overlying the choroidal nevi. Conclusions and Relevance: Adaptive optics imaging may provide high-resolution en face images of retinal structural changes in the photoreceptor mosaic overlying the choroidal nevi...
October 6, 2016: JAMA Ophthalmology
https://www.readbyqxmd.com/read/27521666/swept-source-optical-coherence-tomography-of-choroidal-nevi
#9
Zofia Michalewska, Janusz Michalewski, Jerzy Nawrocki
OBJECTIVE: The aim of this article is to report on retinal and choroidal morphology in choroidal nevi documented with Swept Source optical coherence tomography (SS-OCT). DESIGN: This is a retrospective, observational study. PARTICIPANTS: We included 27 consecutive patients with choroidal nevi. Mean age was 66.3 years (21-95 years). METHODS: The SS-OCT scanning protocol consisted of a single line scan through the centre of the nevi with a resolution of 3 µm, built from 1024 A-scans, with a length of 12 mm...
August 2016: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/27437999/differential-macular-features-on-optical-coherence-tomography-angiography-in-eyes-with-choroidal-nevus-and-melanoma
#10
Alicia Valverde-Megías, Emil A T Say, Sandor R Ferenczy, Carol L Shields
PURPOSE: To evaluate optical coherence tomography angiography (OCTA) characteristics of macular vascular details in eyes with choroidal nevus and melanoma, compared with unaffected contralateral eye. METHODS: Retrospective comparative analysis comprising 70 patients with choroidal nevus and 36 patients with choroidal melanoma examined with optical coherence tomography angiography. Measurements included central macular thickness (CMT), superficial (sFAZ) and deep (dFAZ) foveal avascular zone (FAZ) area, and superficial (sCVD) and deep (dCVD) capillary vascular density (CVD)...
April 2017: Retina
https://www.readbyqxmd.com/read/27433882/photodynamic-therapy-for-choroidal-nevus-with-subfoveal-fluid
#11
Renelle Pointdujour-Lim, Arman Mashayekhi, Jerry A Shields, Carol L Shields
PURPOSE: To report the efficacy of photodynamic therapy (PDT) for management of choroidal nevus associated with subfoveal fluid. METHODS: A retrospective chart review of 15 patients with choroidal nevus and associated subfoveal fluid treated with PDT was performed. Standard-fluence PDT was used in all patients and response to treatment was assessed with optical coherence tomography. RESULTS: Complete resolution of subfoveal fluid was achieved in 9 eyes (60%) and partial resolution in 4 eyes (27%); 1 eye (7%) experienced worsening subfoveal fluid, and 1 eye (7%) was stable after PDT...
April 2017: Retina
https://www.readbyqxmd.com/read/27171585/bilateral-diffuse-uveal-melanocytic-proliferation-presenting-as-a-giant-unilateral-choroidal-nevus-a-case-report
#12
Carlos Menezes, Rui Carvalho, Joana Neves-Martins, Carla Teixeira
BACKGROUND/AIMS: The aim of our study was to report a case of bilateral diffuse uveal melanocytic proliferation (BDUMP) with a markedly asymmetric presentation and fundoscopic response to palliative chemotherapy. CASE REPORT: We report a 67-year-old Caucasian man who presented with vision loss in his right eye. The best-corrected visual acuities were 2/10 in the right eye and 10/10 in the left eye, and biomicroscopy revealed bilateral mild cataracts. Fundoscopy of the right eye showed a macular flat and pigmented lesion extending beyond the posterior pole with areas of giraffe-type pigmentation and an overlying exudative retinal detachment...
September 2015: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/27096381/malignant-transformation-of-a-choroidal-nevus-in-an-eye-treated-for-choroidal-melanoma
#13
Ido D Fabian, Amit K Arora, Victoria M L Cohen
PURPOSE: To report a case of a choroidal melanoma and a discrete choroidal nevus that has transformed into a malignant melanoma 5 years after initial diagnosis. METHODS: Retrospective case report. RESULTS: A diffuse macular choroidal melanoma and a discrete choroidal nevus located superonasal to the optic disk were diagnosed in the right eye of a 63-year-old woman in 2009. The patient was treated by ruthenium plaque radiotherapy for the choroidal melanoma, which consequently flattened and scarred...
April 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/26963960/diffuse-peripapillary-choroidal-melanoma-that-evolved-from-a-small-presumed-choroidal-nevus-successfully-treated-with-gamma-knife-radiotherapy
#14
Jacob S Duker, Jay S Duker
PURPOSE: To report a case of diffuse peripapillary choroidal melanoma which began as a small choroidal nevus and was successfully treated with gamma knife radiotherapy. METHODS: Observational case report. RESULTS: A 31-year-old visually asymptomatic man presented for a routine eye examination and was noted to have a small choroidal nevus. Six years later, the lesion had become a diffuse juxtapapillary choroidal melanoma with a thickness of 1...
2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/26630661/serum-adiponectin-insulin-resistance-and-uveal-melanoma-clinicopathological-correlations
#15
Duygu G Sevim, Hayyam Kiratli
To investigate the status of insulin resistance, metabolic syndrome, dyslipidemia, and serum adiponectin levels in patients with uveal melanoma and choroidal nevus were investigated. Our study included 86 patients with uveal melanoma, 38 patients with choroidal nevus, and 86 controls. Uveal melanomas were classified as small, medium, and large on the basis of Collaborative Ocular Melanoma Study (COMS) criteria. Patients with uveal melanoma had significantly higher homeostatic model assessment scores compared with patients with choroidal nevus (P<0...
April 2016: Melanoma Research
https://www.readbyqxmd.com/read/26599253/spectral-domain-optical-coherence-tomography-of-polypoidal-choroidal-vasculopathy-associated-with-benign-choroidal-nevus
#16
Gabriella De Salvo, Sara Vaz-Pereira, Kulwant S Sehmi, Richard M Andrews, Mandeep S Sagoo
Two cases of polypoidal choroidal vasculopathy (PCV) complicating benign choroidal nevus and their tomographic features at spectral-domain optical coherence tomography (SD-OCT) are reported. Two eyes with choroidal nevus and associated subretinal fluid underwent complete ophthalmological examination, SD-OCT, fundus fluorescein angiography, and indocyanine green angiography (ICGA). SD-OCT and ICGA confirmed the diagnosis of PCV in both cases. Ophthalmologists should be aware of this rare combination between choroidal nevus and PCV...
November 2015: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/26595609/sex-differences-in-the-relationship-between-obesity-and-choroidal-nevus-in-us-adults
#17
Rebecca M Sieburth, Mary Qiu, Carol L Shields
PURPOSE: To investigate sex differences and the effect of other variables on the association between obesity and choroidal nevus in the US adult population. METHODS: The study population of this cross-sectional study included 5575 subjects aged ≥40 years from the 2005 to 2008 National Health and Nutrition Examination Survey (NHANES) who underwent retinal imaging. Primary predictor variables were body mass index (BMI) when the subject was 25 years old ("former BMI") and BMI at time of NHANES participation ("current BMI")...
November 2015: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/26509999/polypoidal-choroidal-vasculopathy-secondary-to-a-stable-choroidal-nevus
#18
James G Wong, Xin Jie Lai, Richard Y Sarafian, Hon Seng Wong, Jeremy B Smith
PURPOSE: Choroidal nevus is the most common ocular fundus tumor in adults. Previous studies have widely discussed the features of choroidal neovascularization secondary to nevus and its treatment options. Polypoidal choroidal vasculopathy (PCV) is an exudative chorioretinopathy that is often underdiagnosed. Clinical features, natural history, and treatment response of PCV are distinct from occult choroidal neovascularization. Polypoidal choroidal vasculopathy secondary to choroidal nevus has not been previously documented...
2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/26402791/relationship-between-female-reproductive-factors-and-choroidal-nevus-in-us-women-analysis-of-data-from-the-2005-2008-national-health-and-nutrition-examination-survey
#19
Mary Qiu, Carol L Shields
IMPORTANCE: Choroidal nevus is a precursor for uveal melanoma and there are no known risk factors besides white race. Female sex hormones have been hypothesized to play a role in the pathogenesis of uveal melanoma. OBJECTIVE: To explore the association between female reproductive factors and choroidal nevus in the US adult female population. DESIGN, SETTING, AND PARTICIPANTS: Cross-sectional, population-based study of 2505 US women aged 40 years or older from the 2005-2008 National Health and Nutrition Examination Survey...
November 2015: JAMA Ophthalmology
https://www.readbyqxmd.com/read/26383622/detection-of-circulating-melanoma-cells-in-choroidal-melanocytic-lesions
#20
Manuel F Bande, Maria Santiago, Laura Muinelo-Romay, Maria Jose Blanco, Purificacion Mera, Carmela Capeans, Maria Pardo, Antonio Piñeiro
PURPOSE: To detect and quantify circulating tumour cells (CTCs) in peripheral blood of patients with uveal melanoma primary non-metastatic tumours, and to analyze the possible relationship between CTCs and clinical risk factors. METHODS: Prospective study with two clinical groups: 4 patients diagnosed with choroidal nevus and 8 patients with choroidal melanoma prior to treatment. A single sample of 7.5 mL of peripheral blood was taken and the CTCs were isolated using a CellSearch system that captures positive cells for the CD146 antigen (MUC18)...
2015: BMC Research Notes
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