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Mathieu Goyette, Jorge Flores-Aranda, Karine Bertrand, Frédérick Pronovost, Valérie Aubut, Roberto Ortiz, Marianne Saint-Jacques
Background: Men who have sex with men (MSM) have distinctive substance use (SU), which is more often linked to a sexual context than it is for their heterosexual peers. Screening of MSM's SU, its sexual contexts and the associated risks, is of clinical and public health concern. This paper aims to describe the preliminary development of a screening tool for health-risk sexual behaviours related to SU and to make recommendations for its potential use. Methods: Community-based participatory research and transdisciplinary approaches guided the development process...
March 16, 2018: Sexual Health
Martin Hitziger, Roberto Esposito, Massimo Canali, Maurizio Aragrande, Barbara Häsler, Simon R Rüegg
The One Health concept covers the interrelationship between human, animal and environmental health and requires multistakeholder collaboration across many cultural, disciplinary, institutional and sectoral boundaries. Yet, the implementation of the One Health approach appears hampered by shortcomings in the global framework for health governance. Knowledge integration approaches, at all stages of policy development, could help to address these shortcomings. The identification of key objectives, the resolving of trade-offs and the creation of a common vision and a common direction can be supported by multicriteria analyses...
March 1, 2018: Bulletin of the World Health Organization
Krzysztof Błażejczyk, Kalev Kuklane
No abstract text is available yet for this article.
March 1, 2018: International Journal of Biometeorology
Santo Fortunato, Carl T Bergstrom, Katy Börner, James A Evans, Dirk Helbing, Staša Milojević, Alexander M Petersen, Filippo Radicchi, Roberta Sinatra, Brian Uzzi, Alessandro Vespignani, Ludo Waltman, Dashun Wang, Albert-László Barabási
Identifying fundamental drivers of science and developing predictive models to capture its evolution are instrumental for the design of policies that can improve the scientific enterprise-for example, through enhanced career paths for scientists, better performance evaluation for organizations hosting research, discovery of novel effective funding vehicles, and even identification of promising regions along the scientific frontier. The science of science uses large-scale data on the production of science to search for universal and domain-specific patterns...
March 2, 2018: Science
Jana Uher
Models and constructs of individual differences are numerous and diverse. But detecting commonalities, differences and interrelations is hindered by the common abstract terms (e.g. 'personality', 'temperament', 'traits') that do not reveal the particular phenomena denoted. This article applies a transdisciplinary paradigm for research on individuals that builds on complexity theory and epistemological complementarity. Its philosophical, metatheoretical and methodological frameworks provide concepts to differentiate various kinds of phenomena (e...
April 19, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Tara Schmidlen, Amy C Sturm, Shelly Hovick, Laura Scheinfeldt, J Scott Roberts, Lindsey Morr, Joseph McElroy, Amanda E Toland, Michael Christman, Julianne M O'Daniel, Erynn S Gordon, Barbara A Bernhardt, Kelly E Ormond, Kevin Sweet
With the advent of widespread genomic testing for diagnostic indications and disease risk assessment, there is increased need to optimize genetic counseling services to support the scalable delivery of precision medicine. Here, we describe how we operationalized the reciprocal engagement model of genetic counseling practice to develop a framework of counseling components and strategies for the delivery of genomic results. This framework was constructed based upon qualitative research with patients receiving genomic counseling following online receipt of potentially actionable complex disease and pharmacogenomics reports...
February 19, 2018: Journal of Genetic Counseling
Jihyoun Jeon, Mengmeng Du, Robert E Schoen, Michael Hoffmeister, Polly A Newcomb, Sonja I Berndt, Bette Caan, Peter T Campbell, Andrew T Chan, Jenny Chang-Claude, Graham G Giles, Jian Gong, Tabitha A Harrison, Jeroen R Huyghe, Eric J Jacobs, Li Li, Yi Lin, Loïc Le Marchand, John D Potter, Flora Qu, Stephanie A Bien, Niha Zubair, Robert J Macinnis, Daniel D Buchanan, John L Hopper, Yin Cao, Reiko Nishihara, Gad Rennert, Martha L Slattery, Duncan C Thomas, Michael O Woods, Ross L Prentice, Stephen B Gruber, Yingye Zheng, Hermann Brenner, Richard B Hayes, Emily White, Ulrike Peters, Li Hsu
BACKGROUND & AIMS: Guidelines for initiating colorectal cancer (CRC) screening are based on family history but do not consider lifestyle, environmental, or genetic risk factors. We developed models to determine risk of CRC, based on lifestyle and environmental factors and genetic variants, and to identify an optimal age to begin screening. METHODS: We collected data from 9748 CRC cases and 10,590 controls in the Genetics and Epidemiology of Colorectal Cancer Consortium and the Colorectal Transdisciplinary study, from 1992 through 2005...
February 16, 2018: Gastroenterology
Simone Mocellin, Saveria Tropea, Clara Benna, Carlo Riccardo Rossi
BACKGROUND: Dysfunction of the circadian clock and single polymorphisms of some circadian genes have been linked to cancer susceptibility, although data are scarce and findings inconsistent. We aimed to investigate the association between circadian pathway genetic variation and risk of developing common cancers based on the findings of genome-wide association studies (GWASs). METHODS: Single nucleotide polymorphisms (SNPs) of 17 circadian genes reported by three GWAS meta-analyses dedicated to breast (Discovery, Biology, and Risk of Inherited Variants in Breast Cancer (DRIVE) Consortium; cases, n = 15,748; controls, n = 18,084), prostate (Elucidating Loci Involved in Prostate Cancer Susceptibility (ELLIPSE) Consortium; cases, n = 14,160; controls, n = 12,724) and lung carcinoma (Transdisciplinary Research In Cancer of the Lung (TRICL) Consortium; cases, n = 12,160; controls, n = 16,838) in patients of European ancestry were utilized to perform pathway analysis by means of the adaptive rank truncated product (ARTP) method...
February 19, 2018: BMC Medicine
J J Steffan, E C Brevik, L C Burgess, A Cerdà
Soil has a considerable effect on human health, whether those effects are positive or negative, direct or indirect. Soil is an important source of nutrients in our food supply and medicines such as antibiotics. However, nutrient imbalances and the presence of human pathogens in the soil biological community can cause negative effects on health. There are also many locations where various elements or chemical compounds are found in soil at toxic levels, because of either natural conditions or anthropogenic activities...
January 2018: European Journal of Soil Science
Richard McMahon
A recently blossoming historiographical literature recognizes that physical anthropologists allied with scholars of diverse aspects of society and history to racially classify European peoples over a period of about a hundred years. They created three successive race classification coalitions - ethnology, from around 1840; anthropology, from the 1850s; and interwar raciology - each of which successively disintegrated. The present genealogical study argues that representing these coalitions as 'transdisciplinary' can enrich our understanding of challenges to disciplinary specialization...
February 8, 2018: British Journal for the History of Science
Courtney K Blackwell, Lauren S Wakschlag, Richard C Gershon, David Cella
PURPOSE OF REVIEW: Diverse methodological approaches pose significant challenges to assess environmental exposure effects on child health outcomes. Although transdisciplinary research efforts offer unique opportunities for understanding the complex and multidimensional facets of lifespan health and disease trajectories, a shared measurement strategy is necessary for ensuring cohesion and comprehensibility across disciplines and domains. RECENT FINDINGS: Exposure science often focuses on one life stage, one primary outcome domain and/or one environmental context without regard for understanding the complexity of exposome pathways and outcomes across a developmental continuum...
February 5, 2018: Current Opinion in Pediatrics
Pi-Shan Hsu, Jui-An Chen, Yu-Tso Chen, Han-Ming Wu, Szu-Ying Lee, Chung-Liang Lai
The baby boom after World War II, coupled with the rapid advances in medical technology and public health, has led to the current rapid aging in the world's population. Countries in Asia are experiencing a faster rate of aging than most other countries around the world. Taiwan is expected to advance from an aged society to a super-aged society in the next 7~10 years. Consequently, the demand for long-term care is increasing. The focus of healthcare has changed from acute to chronic, from disease-oriented to function-oriented and from cure to care...
February 2018: Hu Li za Zhi the Journal of Nursing
Carol Tishelman
Public health and health promotion approaches to end-of-life (EoL) research and care are still rare in Sweden. People remain generally ill-prepared for encounters with death and unable to advocate for quality EoL care; this may be reflected in Sweden's low scores for community engagement in the 2015 Quality of Death index. We have consolidated our endeavours into a cohesive national transdisciplinary research program, DöBra (a pun meaning both 'dying well' and 'awesome' in Swedish). In DöBra, we investigate how culture, the environment and conversation can promote constructive change and support better quality of life and death among the general population, in specific subgroups and in interventions directed to staff caring for dying individuals, their friends and families...
January 2018: Annals of Palliative Medicine
Rehana Shrestha, Johannes Flacke, Javier Martinez, Martin van Maarseveen
Cumulative burden assessment (CuBA) has the potential to inform planning and decision-making on health disparities related to multiple environmental burdens. However, scholars have raised concerns about the social complexity to be dealt with while conducting CuBA, suggesting that it should be addressed in an adaptive, participatory and transdisciplinary (APT) approach. APT calls for deliberation among stakeholders by engaging them in a process of social learning and knowledge co-production. We propose an interactive stakeholder-based approach that facilitates a science-based stakeholder dialogue as an interface for combining different knowledge domains and engendering social learning in CuBA processes...
February 3, 2018: International Journal of Environmental Research and Public Health
Anna R Davies, Ferne Edwards, Brigida Marovelli, Oona Morrow, Monika Rut, Marion Weymes
Activities utilising online tools are an increasingly visible part of our everyday lives, providing new subjects, objects and relationships - essentially new landscapes - for research, as well as new conceptual and methodological challenges for researchers. In parallel, calls for collaborative interdisciplinary, even transdisciplinary, research are increasing. Yet practical guidance and critical reflection on the challenges and opportunities of conducting collaborative research online, particularly in emergent areas, is limited...
December 2017: Area (Oxf)
Tiffany Brazile, Glenda Hostetter Shoop, Christine M McDonough, Douglas W Van Citters
PURPOSE: Addressing current healthcare challenges requires innovation and collaboration. Current literature provides limited guidance in promoting these skills in medical school. One approach involves transdisciplinary training in which students from different disciplines work together toward a shared goal. We assessed the need for such a curriculum at Dartmouth College. METHODS: We surveyed medical and engineering students' educational values; learning experiences; professional goals; and interest in transdisciplinary education and innovation...
January 30, 2018: Medical Teacher
Giang Pham, Steven Lam, Tung Dinh-Xuan, Hung Nguyen-Viet
CONTEXT: Ecohealth is a transdisciplinary research approach that considers socio-economic, cultural, and environmental factors. Ecohealth program assessment is sometimes unable to capture the process of change, especially when the evidence is not well documented. As such, there is a need to better understand how ecohealth approaches are understood, integrated, and adapted in practice to support the sustainability of the approach. OBJECTIVE: To evaluate the use of an ecohealth approach to a community-based intervention to improve environmental sanitation and draw lessons learned for similar public health initiatives...
March 2018: Journal of Public Health Management and Practice: JPHMP
Prakesh S Shah, Sarah D McDonald, Jon Barrett, Anne Synnes, Kate Robson, Jonathan Foster, Jean-Charles Pasquier, K S Joseph, Bruno Piedboeuf, Thierry Lacaze-Masmonteil, Karel O'Brien, Sandesh Shivananda, Nils Chaillet, Petros Pechlivanoglou
BACKGROUND: Preterm birth (birth before 37 wk of gestation) occurs in about 8% of pregnancies in Canada and is associated with high mortality and morbidity rates that substantially affect infants, their families and the health care system. Our overall goal is to create a transdisciplinary platform, the Canadian Preterm Birth Network (CPTBN), where investigators, stakeholders and families will work together to improve childhood outcomes of preterm neonates. METHODS: Our national cohort will include 24 maternal-fetal/obstetrical units, 31 neonatal intensive care units and 26 neonatal follow-up programs across Canada with planned linkages to provincial health information systems...
January 18, 2018: CMAJ Open
Akriti Gupta, Satendra Singh, Farah Khaliq, Upreet Dhaliwal, S V Madhu
In the country presently, preclinical medical students are not routinely exposed to real patients. Thus, when they start clinical postings, they are found to have poor clinical reasoning skills. Simulated virtual patients (SVPs) can improve clinical skills without endangering real patients. This pilot study describes the development of two SVPs in endocrine physiology and their validation in terms of acquisition of clinical knowledge and student engagement. Two SVPs, Nandini Sharma (unintentional weight gain) and Sunil Yadav (polyuria), were created and published on the i-Human Patients platform through an iterative, interdisciplinary, and transdisciplinary collaborative process using the conceptual framework of Kim et al...
March 1, 2018: Advances in Physiology Education
Daniela Oliveira, Catia Pesquita
BACKGROUND: Ontologies are commonly used to annotate and help process life sciences data. Although their original goal is to facilitate integration and interoperability among heterogeneous data sources, when these sources are annotated with distinct ontologies, bridging this gap can be challenging. In the last decade, ontology matching systems have been evolving and are now capable of producing high-quality mappings for life sciences ontologies, usually limited to the equivalence between two ontologies...
January 9, 2018: Journal of Biomedical Semantics
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