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https://www.readbyqxmd.com/read/28325736/geospatial-approaches-to-cancer-control-and-population-sciences
#1
EDITORIAL
Mario Schootman, Scarlett Lin Gomez, Kevin A Henry, Electra D Paskett, Gary L Ellison, April Oh, Stephen H Taplin, Zaria Tatalovich, David A Berrigan
Cancer incidence and mortality display strong geographic patterns worldwide and in the United States (1, 2). The environment where individuals live, work, and play is increasingly being recognized as important across the cancer control continuum, including the risk of cancer development, detection, diagnosis, treatment, mortality, and survivorship (3-5). At the same time, emergent technological capacity in geographic information systems (GIS) and mapping, along with increasing sophistication in applied spatial methods, has resulted in a growing research community developing and applying geospatial approaches in health research (5)...
March 21, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28304396/associations-between-genetic-variants-in-mrna-splicing-related-genes-and-risk-of-lung-cancer-a-pathway-based-analysis-from-published-gwass
#2
Yongchu Pan, Hongliang Liu, Yanru Wang, Xiaozheng Kang, Zhensheng Liu, Kouros Owzar, Younghun Han, Li Su, Yongyue Wei, Rayjean J Hung, Yonathan Brhane, John McLaughlin, Paul Brennan, Heike Bickeböller, Albert Rosenberger, Richard S Houlston, Neil Caporaso, Maria Teresa Landi, Joachim Heinrich, Angela Risch, Xifeng Wu, Yuanqing Ye, David C Christiani, Christopher I Amos, Qingyi Wei
mRNA splicing is an important mechanism to regulate mRNA expression. Abnormal regulation of this process may lead to lung cancer. Here, we investigated the associations of 11,966 single-nucleotide polymorphisms (SNPs) in 206 mRNA splicing-related genes with lung cancer risk by using the summary data from six published genome-wide association studies (GWASs) of Transdisciplinary Research in Cancer of the Lung (TRICL) (12,160 cases and 16,838 controls) and another two lung cancer GWASs of Harvard University (984 cases and 970 controls) and deCODE (1,319 cases and 26,380 controls)...
March 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28302101/preventing-diabetes-in-obese-latino-youth-with-prediabetes-a-study-protocol-for-a-randomized-controlled-trial
#3
Erica G Soltero, Yolanda P Konopken, Micah L Olson, Colleen S Keller, Felipe G Castro, Allison N Williams, Donald L Patrick, Stephanie Ayers, Houchun H Hu, Matthew Sandoval, Janiel Pimentel, William C Knowler, Kevin D Frick, Gabriel Q Shaibi
BACKGROUND: Obese Latino adolescents are disproportionately impacted by insulin resistance and type 2 diabetes. Prediabetes is an intermediate stage in the pathogenesis of type 2 diabetes and represents a critical opportunity for intervention. However, to date, no diabetes prevention studies have been conducted in obese Latino youth with prediabetes, a highly vulnerable and underserved group. Therefore, we propose a randomized-controlled trial to test the short-term (6-month) and long-term (12-month) efficacy of a culturally-grounded, lifestyle intervention, as compared to usual care, for improving glucose tolerance and reducing diabetes risk in 120 obese Latino adolescents with prediabetes...
March 16, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28298877/applying-structural-systems-thinking-to-frame-perspectives-on-social-work-innovation
#4
Erin J Stringfellow
OBJECTIVE: Innovation will be key to the success of the Grand Challenges Initiative in social work. A structural systems framework based in system dynamics could be useful for considering how to advance innovation. METHOD: Diagrams using system dynamics conventions were developed to link common themes across concept papers written by social work faculty members and graduate students (N = 19). RESULTS: Transdisciplinary teams and ethical partnerships with communities and practitioners will be needed to responsibly develop high-quality innovative solutions...
March 2017: Research on Social Work Practice
https://www.readbyqxmd.com/read/28270610/eliciting-probabilistic-expectations-collaborations-between-psychologists-and-economists
#5
Wändi Bruine de Bruin, Baruch Fischhoff
We describe two collaborations in which psychologists and economists provided essential support on foundational projects in major research programs. One project involved eliciting adolescents' expectations regarding significant future life events affecting their psychological and economic development. The second project involved eliciting consumers' expectations regarding inflation, a potentially vital input to their investment, saving, and purchasing decisions. In each project, we sought questions with the precision needed for economic modeling and the simplicity needed for lay respondents...
March 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28267154/natural-hazard-management-from-a-coevolutionary-perspective-exposure-and-policy-response-in-the-european-alps
#6
Sven Fuchs, Veronika Röthlisberger, Thomas Thaler, Andreas Zischg, Margreth Keiler
A coevolutionary perspective is adopted to understand the dynamics of exposure to mountain hazards in the European Alps. A spatially explicit, object-based temporal assessment of elements at risk to mountain hazards (river floods, torrential floods, and debris flows) in Austria and Switzerland is presented for the period from 1919 to 2012. The assessment is based on two different data sets: (1) hazard information adhering to legally binding land use planning restrictions and (2) information on building types combined from different national-level spatial data...
March 4, 2017: Annals of the American Association of Geographers
https://www.readbyqxmd.com/read/28261580/a-blueprint-to-evaluate-one-health
#7
Simon R Rüegg, Barry J McMahon, Barbara Häsler, Roberto Esposito, Liza Rosenbaum Nielsen, Chinwe Ifejika Speranza, Timothy Ehlinger, Marisa Peyre, Maurizio Aragrande, Jakob Zinsstag, Philip Davies, Andrei Daniel Mihalca, Sandra C Buttigieg, Jonathan Rushton, Luís P Carmo, Daniele De Meneghi, Massimo Canali, Maria E Filippitzi, Flavie Luce Goutard, Vlatko Ilieski, Dragan Milićević, Helen O'Shea, Miroslav Radeski, Richard Kock, Anthony Staines, Ann Lindberg
One Health (OH) positions health professionals as agents for change and provides a platform to manage determinants of health that are often not comprehensively captured in medicine or public health alone. However, due to the organization of societies and disciplines, and the sectoral allocation of resources, the development of transdisciplinary approaches requires effort and perseverance. Therefore, there is a need to provide evidence on the added value of OH for governments, researchers, funding bodies, and stakeholders...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28257289/the-inaugural-nec-symposium-a-transdisciplinary-approach-to-tackle-necrotizing-enterocolitis-in-us-neonatal-intensive-care-units
#8
Sheila M Gephart, Wakako M Eklund
No abstract text is available yet for this article.
March 2, 2017: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
https://www.readbyqxmd.com/read/28241508/accelerators-sparking-innovation-and-transdisciplinary-team-science-in-disparities-research
#9
Carol R Horowitz, Khader Shameer, Janice Gabrilove, Ashish Atreja, Peggy Shepard, Crispin N Goytia, Geoffrey W Smith, Joel Dudley, Rachel Manning, Nina A Bickell, Maida P Galvez
Development and implementation of effective, sustainable, and scalable interventions that advance equity could be propelled by innovative and inclusive partnerships. Readied catalytic frameworks that foster communication, collaboration, a shared vision, and transformative translational research across scientific and non-scientific divides are needed to foster rapid generation of novel solutions to address and ultimately eliminate disparities. To achieve this, we transformed and expanded a community-academic board into a translational science board with members from public, academic and private sectors...
February 23, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28235453/leveraging-neuroscience-to-inform-adolescent-health-the-need-for-an-innovative-transdisciplinary-developmental-science-of-adolescence
#10
REVIEW
Ahna Ballonoff Suleiman, Ronald E Dahl
In this article, we consider how to leverage some of the rapid advances in developmental neuroscience in ways that can improve adolescent health. We provide a brief overview of several key areas of scientific progress relevant to these issues. We then focus on two examples of important health problems that increase sharply during adolescence: sleep problems and affective disorders. These examples illustrate how an integrative, developmental science approach provides new insights into treatment and intervention...
March 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28216369/role-of-socio-cultural-and-economic-factors-in-cyprinid-fish-distribution-networks-and-consumption-in-lawa-lake-region-northeast-thailand-novel-perspectives-on-opisthorchis-viverrini-transmission-dynamics
#11
Christina Sunyoung Kim, John F Smith, Apiporn Suwannatrai, Pierre Echaubard, Bruce Wilcox, Sasithorn Kaewkes, Paiboon Sithithaworn, Banchob Sripa
Opisthorchis viverrini (Ov) is a fish-borne parasite endemic in parts of Lao PDR, Cambodia, southern Vietnam and Northeast Thailand (Isaan) where an estimated 10 million people are infected. Human Ov infection, associated with hepatobiliary complications, including cholangiocarcinoma (CCA), occurs when infected fish are consumed raw or undercooked, a longstanding cultural tradition in the region. This mixed- methods descriptive study was carried out in Isaan villages around Lawa Lake, Khon Kaen Province, known for their Ov endemicity...
February 16, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28209610/the-tumor-microenvironment-at-a-turning-point-knowledge-gained-over-the-last-decade-and-challenges-and-opportunities-ahead-a-white-paper-from-the-nci-tme-network
#12
Yves A DeClerck, Kenneth J Pienta, Elisa C Woodhouse, Dinah S Singer, Suresh Mohla
Over the past 10 years, the Tumor Microenvironment Network (TMEN), supported by the NCI (Bethesda, MD), has promoted collaborative research with the explicit goal of fostering multi-institutional and transdisciplinary groups that are capable of addressing complex issues involving the tumor microenvironment. The main goal of the TMEN was to generate novel information about the dynamic complexity of tumor-host interactions in different organ systems with emphasis on using human tissues and supplemented by experimental models...
March 1, 2017: Cancer Research
https://www.readbyqxmd.com/read/28190688/antimony-as-a-global-dilemma-geochemistry-mobility-fate-and-transport
#13
REVIEW
Indika Herath, Meththika Vithanage, Jochen Bundschuh
Elevated concentrations of antimony (Sb) in environmental, biological and geochemical systems originating from natural, geological and anthropogenic sources are of particular global concern. This review presents a critical overview of natural geochemical processes which trigger the mobilization of Sb from its host mineral phases and related rocks to the surrounding environments. The primary source of Sb contamination in the environment is geogenic. The geochemical characteristics of Sb are determined by its oxidation states, speciation and redox transformation...
April 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28182757/horticultural-systems-engineering-and-economic-evaluations-of-short-term-plant-storage-techniques-as-a-labor-management-tool-for-vegetable-grafting-nurseries
#14
Chieri Kubota, Chao Meng, Young-Jun Son, Myles Lewis, Hans Spalholz, Russell Tronstad
This transdisciplinary study has a three-fold systems approach in evaluating a horticultural technology: 1) horticultural evaluations, 2) economic and resource analyses, and 3) systems engineering analyses, using low temperature storage as an example technology. Vegetable grafting is a technique to produce value-added seedlings but requires labor intensive nursery operations. Low temperature storage of seedlings for a short period of time can reduce peak production, but has not been evaluated at the extent demonstrated in this paper...
2017: PloS One
https://www.readbyqxmd.com/read/28179575/key-lessons-learned-from-moffitt-s-molecular-tumor-board-the-clinical-genomics-action-committee-experience
#15
Todd C Knepper, Gillian C Bell, J Kevin Hicks, Eric Padron, Jamie K Teer, Teresa T Vo, Nancy K Gillis, Neil T Mason, Howard L McLeod, Christine M Walko
BACKGROUND: The increasing practicality of genomic sequencing technology has led to its incorporation into routine clinical practice. Successful identification and targeting of driver genomic alterations that provide proliferative and survival advantages to tumor cells have led to approval and ongoing development of several targeted cancer therapies. Within many major cancer centers, molecular tumor boards are constituted to shepherd precision medicine into clinical practice. MATERIALS AND METHODS: In July 2014, the Clinical Genomics Action Committee (CGAC) was established as the molecular tumor board companion to the Personalized Medicine Clinical Service (PMCS) at Moffitt Cancer Center in Tampa, Florida...
February 8, 2017: Oncologist
https://www.readbyqxmd.com/read/28152172/the-abc-model-of-prostate-cancer-a-conceptual-framework-for-the-design-and-interpretation-of-prognostic-studies
#16
REVIEW
Andreas Pettersson, Travis Gerke, Katja Fall, Yudi Pawitan, Lars Holmberg, Edward L Giovannucci, Philip W Kantoff, Hans-Olov Adami, Jennifer R Rider, Lorelei A Mucci
There has been limited success in identifying prognostic biomarkers in prostate cancer. A partial explanation may be that insufficient emphasis has been put on clearly defining what type of marker or patient category a biomarker study aims to identify and how different cohort characteristics affect the ability to identify such a marker. In this article, the authors put forth the ABC model of prostate cancer, which defines 3 groups of patients with localized disease that an investigator may seek to identify: patients who, within a given time frame, will not develop metastases even if untreated (category A), will not develop metastases because of radical treatment (category B), or will develop metastases despite radical treatment (category C)...
February 2, 2017: Cancer
https://www.readbyqxmd.com/read/28150878/pathway-analysis-of-published-genome-wide-association-studies-of-lung-cancer-a-potential-role-for-the-cyp4f3-locus
#17
Jieyun Yin, Hongliang Liu, Zhensheng Liu, Kouros Owzar, Younghun Han, Li Su, Yongyue Wei, Rayjean J Hung, Yonathan Brhane, John McLaughlin, Paul Brennan, Heike Bickeboeller, Albert Rosenberger, Richard S Houlston, Neil Caporaso, Maria Teresa Landi, Joachim Heinrich, Angela Risch, David C Christiani, Christopher I Amos, Qingyi Wei
The fatty acids (FAs) metabolism is suggested to play a pivotal role in the development of lung cancer, and we explored that by conducting a pathway-based analysis. We performed a meta-analysis of published datasets of six genome wide association studies (GWASs) from the Transdisciplinary Research in Cancer of the Lung (TRICL) consortium, which included 12 160 cases with lung cancer and 16 838 cancer-free controls. A total of 30 722 single-nucleotide polymorphisms (SNPs) from 317 genes relevant to FA metabolic pathways were identified...
February 2, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28137753/is-human-fecundity-changing-a-discussion-of-research-and-data-gaps-precluding-us-from-having-an-answer
#18
REVIEW
Melissa M Smarr, Katherine J Sapra, Alison Gemmill, Linda G Kahn, Lauren A Wise, Courtney D Lynch, Pam Factor-Litvak, Sunni L Mumford, Niels E Skakkebaek, Rémy Slama, Danelle T Lobdell, Joseph B Stanford, Tina Kold Jensen, Elizabeth Heger Boyle, Michael L Eisenberg, Paul J Turek, Rajeshwari Sundaram, Marie E Thoma, Germaine M Buck Louis
Fecundity, the biologic capacity to reproduce, is essential for the health of individuals and is, therefore, fundamental for understanding human health at the population level. Given the absence of a population (bio)marker, fecundity is assessed indirectly by various individual-based (e.g. semen quality, ovulation) or couple-based (e.g. time-to-pregnancy) endpoints. Population monitoring of fecundity is challenging, and often defaults to relying on rates of births (fertility) or adverse outcomes such as genitourinary malformations and reproductive site cancers...
January 30, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28097472/proceedings-of-the-third-international-molecular-pathological-epidemiology-mpe-meeting
#19
REVIEW
Peter T Campbell, Timothy R Rebbeck, Reiko Nishihara, Andrew H Beck, Colin B Begg, Alexei A Bogdanov, Yin Cao, Helen G Coleman, Gordon J Freeman, Yujing J Heng, Curtis Huttenhower, Rafael A Irizarry, N Sertac Kip, Franziska Michor, Daniel Nevo, Ulrike Peters, Amanda I Phipps, Elizabeth M Poole, Zhi Rong Qian, John Quackenbush, Harlan Robins, Peter K Rogan, Martha L Slattery, Stephanie A Smith-Warner, Mingyang Song, Tyler J VanderWeele, Daniel Xia, Emily C Zabor, Xuehong Zhang, Molin Wang, Shuji Ogino
Molecular pathological epidemiology (MPE) is a transdisciplinary and relatively new scientific discipline that integrates theory, methods, and resources from epidemiology, pathology, biostatistics, bioinformatics, and computational biology. The underlying objective of MPE research is to better understand the etiology and progression of complex and heterogeneous human diseases with the goal of informing prevention and treatment efforts in population health and clinical medicine. Although MPE research has been commonly applied to investigating breast, lung, and colorectal cancers, its methodology can be used to study most diseases...
February 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28068888/the-georgetown-symposium-on-global-mental-health-transdisciplinary-perspectives
#20
Emily Mendenhall
No abstract text is available yet for this article.
January 10, 2017: Global Public Health
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