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Weight Loss Maintenance

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https://www.readbyqxmd.com/read/29333595/implanted-closed-loop-gastric-electrical-stimulation-clges-system-with-sensor-based-feedback-safely-limits-weight-regain-at-24%C3%A2-months
#1
S Morales-Conde, I Alarcón Del Agua, L Busetto, F Favretti, M Anselmino, G M Rovera, M Socas-Macias, A Barranco-Moreno, R Province-Azalde, A J Torres
BACKGROUND: Weight regain following bariatric surgery is not uncommon. Safe, effective weight loss treatment up to 1 year has been reported with the closed-loop gastric electrical stimulation (CLGES) system. Continuous recording of eating and activity behavior by onboard sensors is one of the novel features of this closed-loop electrical stimulation therapy, and may provide improved long-term weight maintenance by enhancing aftercare. METHODS: Four centers participating in a 12-month prospective multicenter randomized study monitored all implanted participants (n = 47) up to 24 months after laparoscopic implantation of a CLGES system...
January 15, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29329344/maintenance-of-muscle-strength-retains-a-normal-metabolic-cost-in-simulated-walking-after-transtibial-limb-loss
#2
Elizabeth Russell Esposito, Ross H Miller
Recent studies on relatively young and fit individuals with limb loss suggest that maintaining muscle strength after limb loss may mitigate the high metabolic cost of walking typically seen in the larger general limb loss population. However, these data are cross-sectional and the muscle strength prior to limb loss is unknown, and it is therefore difficult to draw causal inferences on changes in strength and gait energetics. Here we used musculoskeletal modeling and optimal control simulations to perform a longitudinal study (25 virtual "subjects") of the metabolic cost of walking pre- and post-limb loss (unilateral transtibial)...
2018: PloS One
https://www.readbyqxmd.com/read/29320341/long-term-weight-maintenance-after-successful-weight-loss-motivational-factors-support-difficulties-and-success-factors
#3
Sirpa Soini, Pertti Mustajoki, Johan G Eriksson
OBJECTIVES: The main aims of this study were to assess motivational factors for weight loss, and support and difficulties during the weight loss and weight maintenance phase. METHODS: This study was based upon findings from the Finnish Weight Control Registry (FWCR), including 158 formerly obese persons, who lost at least 10% of their initial weight and maintained it for at least 2 years. Data have been collected through electronic forms. RESULTS: The 2 most commonly reported motivational factors for weight loss were health- and appearance-related factors...
January 1, 2018: American Journal of Health Behavior
https://www.readbyqxmd.com/read/29318342/group-cognitive-behavioural-therapy-and-weight-regain-after-diet-in-type-2-diabetes-results-from-the-randomised-controlled-power-trial
#4
Kirsten A Berk, Hanneke I M Buijks, Adrie J M Verhoeven, Monique T Mulder, Behiye Özcan, Adriaan van 't Spijker, Reinier Timman, Jan J Busschbach, Eric J Sijbrands
AIMS/HYPOTHESIS: Weight-loss programmes for adults with type 2 diabetes are less effective in the long term owing to regain of weight. Our aim was to determine the 2 year effectiveness of a cognitive behavioural group therapy (group-CBT) programme in weight maintenance after diet-induced weight loss in overweight and obese adults with type 2 diabetes, using a randomised, parallel, non-blinded, pragmatic study design. METHODS: We included 158 obese adults (median BMI 36...
January 9, 2018: Diabetologia
https://www.readbyqxmd.com/read/29314206/follicular-lymphoma-2018-update-on-diagnosis-and-management
#5
Arnold Freedman
DISEASE OVERVIEW: Follicular lymphoma is generally an indolent B cell lymphoproliferative disorder of transformed follicular center B cells. Follicular lymphoma (FL) is characterized by diffuse lymphadenopathy, bone marrow involvement, splenomegaly and less commonly other extranodal sites of involvement. In general, cytopenias can occur but constitutional symptoms of fever, nightsweats, and weight loss are uncommon. DIAGNOSIS: Diagnosis is based on histology of preferably a biopsy of a lymph node...
February 2018: American Journal of Hematology
https://www.readbyqxmd.com/read/29310572/support-needs-of-patients-with-obesity-in-primary-care-a-practice-list-survey
#6
Elizabeth H Evans, Kirby Sainsbury, Dominika Kwasnicka, Alex Bolster, Vera Araujo-Soares, Falko F Sniehotta
BACKGROUND: UK guidelines recommend that patients with obesity in primary care receive opportunistic weight loss advice from health care professionals, but there is a lack of research into the characteristics and existing weight management practices of these patients. The aim of this study was to characterise primary care patients with obesity in England, to inform the screening, support, and referral options appropriate to this group. METHODS: We surveyed 1309 patients registered at 15 GP practices in North East England, aged ≥18 years and with objectively recorded obesity (BMI ≥ 30 kg/m2)...
January 8, 2018: BMC Family Practice
https://www.readbyqxmd.com/read/29289702/study-protocol-for-log2lose-a-feasibility-randomized-controlled-trial-to-evaluate-financial-incentives-for-dietary-self-monitoring-and-interim-weight-loss-in-adults-with-obesity
#7
Corrine I Voils, Erica Levine, Jennifer M Gierisch, Jane Pendergast, Sarah L Hale, Megan A McVay, Shelby D Reed, William S Yancy, Gary Bennett, Elizabeth M Strawbridge, Allison C White, Ryan J Shaw
The obesity epidemic has negative physical, psychological, and financial consequences. Despite the existence of effective behavioral weight loss interventions, many individuals do not achieve adequate weight loss, and most regain lost weight in the year following intervention. We report the rationale and design for a 2×2 factorial study that involves financial incentives for dietary self-monitoring (yes vs. no) and/or interim weight loss (yes vs. no). Outpatients with obesity participate in a 24-week, group-based weight loss intervention...
December 28, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29288880/diuretics-combined-with-compression-in-resistant-limb-edema-of-advanced-disease-a-case-series-report
#8
Tomasz Gradalski
INTRODUCTION: The extremity edema of advanced disease is a common, multifactorial feature, which impairs patient activities and quality of life. The most frequently chosen management is based on combined decongestive physiotherapy or pharmacotherapy (with diuretics or steroids). Subcutaneous lymphatic drainage in refractory edema may decrease the swelling, prevent spontaneous lymphorrhoea but also increase the risk of infection. Safe and effective conservative management in diuretics resistant edemas is lacking...
December 27, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29288545/a-randomized-trial-of-lorcaserin-and-lifestyle-counseling-for-maintaining-weight-loss-achieved-with-a-low-calorie-diet
#9
Jena Shaw Tronieri, Thomas A Wadden, Robert I Berkowitz, Ariana M Chao, Rebecca L Pearl, Naji Alamuddin, Sharon M Leonard, Ray Carvajal, Zayna M Bakizada, Emilie Pinkasavage, Kathryn A Gruber, Olivia A Walsh, Nasreen Alfaris
OBJECTIVE: Improving the maintenance of lost weight remains a critical challenge, which can be addressed by long-term behavioral and/or pharmacological interventions. METHODS: This study investigated the efficacy of combined behavioral and pharmacological treatment in facilitating weight loss maintenance (WLM) in 137 adults (86.1% female; 68.6% black; BMI = 37.0 ± 5.6 kg/m2 ) who had lost ≥ 5% of initial weight during a 14-week low-calorie diet (LCD) program (mean = 9...
December 29, 2017: Obesity
https://www.readbyqxmd.com/read/29278718/a-randomised-controlled-trial-of-manualized-cognitive-remediation-therapy-in-adult-obesity
#10
Jayanthi Raman, Phillipa Hay, Kate Tchanturia, Evelyn Smith
OBJECTIVE: Research has indicated that individuals with obesity have neurocognitive deficits, especially in cognitive flexibility that may in turn impact on their weight loss and maintenance. Consequently, we examined the efficacy of a manualised face-to-face cognitive remediation therapy for obesity (CRT-O) within a randomised controlled trial, in terms of improving cognitive flexibility, reducing binge eating behavior, improving quality of life and helping with weight loss. METHODS: 80 adults with obesity (body mass index >30 kg/m2), 70% binge eaters, received three weekly sessions of group Behavioural Weight Loss (BWL) and then were randomised to 8 sessions of individual CRT-O or to a no-treatment control group...
December 23, 2017: Appetite
https://www.readbyqxmd.com/read/29274742/effect-of-early-embryonic-deletion-of-huntingtin-from-pyramidal-neurons-on-the-development-and-long-term-survival-of-neurons-in-cerebral-cortex-and-striatum
#11
I Dragatsis, P Dietrich, H Ren, Y P Deng, N Del Mar, H B Wang, I M Johnson, K R Jones, A Reiner
We evaluated the impact of early embryonic deletion of huntingtin (htt) from pyramidal neurons on cortical development, cortical neuron survival and motor behavior, using a cre-loxP strategy to inactivate the mouse htt gene (Hdh) in emx1-expressing cell lineages. Western blot confirmed substantial htt reduction in cerebral cortex of these Emx-httKO mice, with residual cortical htt in all likelihood restricted to cortical interneurons of the subpallial lineage and/or vascular endothelial cells. Despite the loss of htt early in development, cortical lamination was normal, as revealed by layer-specific markers...
December 21, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/29261744/energy-homeostasis-in-leptin-deficient-lepob-ob-mice
#12
Alicja A Skowronski, Yann Ravussin, Rudolph L Leibel, Charles A LeDuc
Maintenance of reduced body weight is associated both with reduced energy expenditure per unit metabolic mass and increased hunger in mice and humans. Lowered circulating leptin concentration, due to decreased fat mass, provides a primary signal for this response. However, leptin deficient (Lepob/ob) mice (and leptin receptor deficient Zucker rats) reduce energy expenditure following weight reduction by a necessarily non-leptin dependent mechanisms. To identify these mechanisms, Lepob/ob mice were fed ad libitum (AL group; n = 21) or restricted to 3 kilocalories of chow per day (CR group, n = 21)...
2017: PloS One
https://www.readbyqxmd.com/read/29259801/treatment-with-liraglutide-may-improve-markers-of-cvd-reflected-by-reduced-levels-of-apob
#13
L Engelbrechtsen, J Lundgren, N J Wewer Albrechtsen, Y Mahendran, E W Iepsen, P Finocchietto, A E Jonsson, S Madsbad, J J Holst, H Vestergaard, T Hansen, S S Torekov
Background: Dislipidaemia and increased levels of apolipoprotein B (apoB) in individuals with obesity are risk factors for development of cardiovascular disease (CVD). The aim of this study was to investigate the effect of weight loss and weight maintenance with and without liraglutide treatment on plasma lipid profiles and apoB. Methods: Fifty-eight individuals with obesity (body mass index 34.5 ± 3.0 kg/m2 [mean ± SD]) were included in this study. After 8 weeks on a very low-calorie diet (800 kcal/day), participants were randomized to weight maintenance with meal replacements with or without liraglutide (1...
December 2017: Obesity Science & Practice
https://www.readbyqxmd.com/read/29239141/characterizing-the-pattern-of-weight-loss-and-regain-in-adults-enrolled-in-a-12-week-internet-based-weight-management-program
#14
Kathryn M Ross, Peihua Qiu, Lu You, Rena R Wing
OBJECTIVE: Although the trajectory of weight change during and/or after behavioral weight management interventions is believed to include a period of weight loss followed by maintenance and later regain, the sparse data produced by existing study designs (conducting assessments at 3- to 6-month intervals) have limited investigation into the precise pattern. METHODS: Seventy-five adults were asked to self-weigh daily via "smart" scales during a 12-week, Internet-based weight loss program and for an additional 9 months with no further intervention...
December 13, 2017: Obesity
https://www.readbyqxmd.com/read/29237801/adolescent-loss-of-control-eating-and-weight-loss-maintenance-after-bariatric-surgery
#15
Andrea B Goldschmidt, Jane Khoury, Todd M Jenkins, Dale S Bond, J Graham Thomas, Linsey M Utzinger, Meg H Zeller, Thomas H Inge, James E Mitchell
BACKGROUND: Loss-of-control (LOC) eating is common in adults undergoing bariatric surgery and is associated with poorer weight outcomes. Its long-term course in adolescent bariatric surgery patients and associations with weight outcomes are unclear. METHODS: Adolescents (n = 234; age range = 13-19 years) undergoing bariatric surgery across 5 US sites were assessed for postsurgery follow-up at 6 months and 1, 2, 3, and 4 years. Descriptive statistics and generalized linear mixed models were used to describe the prevalence of LOC eating episodes involving objectively large amounts of food and continuous eating, respectively...
December 13, 2017: Pediatrics
https://www.readbyqxmd.com/read/29233806/mobile-health-technology-mdiab-for-the-prevention-of-type-2-diabetes-protocol-for-a-randomized-controlled-trial
#16
Shruti Muralidharan, Viswanathan Mohan, Ranjit Mohan Anjana, Sidhant Jena, Nikhil Tandon, Steven Allender, Harish Ranjani
BACKGROUND: The prevalence of type 2 diabetes is increasing in epidemic proportions in low- and middle-income countries. There is an urgent need for novel methods to tackle the increasing incidence of diabetes. The ubiquity of mobile phone use and access to Internet makes mobile health (mHealth) technology a viable tool to prevent and manage diabetes. OBJECTIVE: The objective of this randomized controlled trial is to implement and evaluate the feasibility, cost-effectiveness, and sustainability of a reality television-based lifestyle intervention program...
December 12, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/29233719/a-randomized-study-of-dietary-composition-during-weight-loss-maintenance-rationale-study-design-intervention-and-assessment
#17
Cara B Ebbeling, Gloria L Klein, Patricia K Luoto, Julia M W Wong, Lisa Bielak, Ralph G Eddy, Sarah K Steltz, Courtenay Devlin, Megan Sandman, Bridget Hron, Kim Shimy, Steven B Heymsfield, Robert R Wolfe, William W Wong, Henry A Feldman, David S Ludwig
BACKGROUND: While many people with overweight or obesity can lose weight temporarily, most have difficulty maintaining weight loss over the long term. Studies of dietary composition typically focus on weight loss, rather than weight-loss maintenance, and rely on nutrition education and dietary counseling, rather than controlled feeding protocols. Variation in initial weight loss and insufficient differentiation among treatments confound interpretation of results and compromise conclusions regarding the weight-independent effects of dietary composition...
December 9, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29233169/an-evidence-based-gamified-mhealth-intervention-for-overweight-young-adults-with-maladaptive-eating-habits-study-protocol-for-a-randomized-controlled-trial
#18
Ioana R Podina, Liviu A Fodor, Ana Cosmoiu, Rareș Boian
BACKGROUND: Cognitive behavior therapy (CBT) is the first-line of treatment for overweight and obesity patients whose problems originate in maladaptive eating habits (e.g., emotional eating). However, in-person CBT is currently difficult to access by large segments of the population. The proposed SIGMA intervention (i.e., the Self-help, Integrated, and Gamified Mobile-phone Application) is a mHealth intervention based on CBT principles. It specifically targets overweight young adults with underlying maladaptive behaviors and cognitions regarding food...
December 12, 2017: Trials
https://www.readbyqxmd.com/read/29230381/exploring-process-variables-through-which-acceptance-based-behavioral-interventions-may-improve-weight-loss-maintenance
#19
J Lillis, J G Thomas, H M Niemeier, R R Wing
Objective: A previously published randomized trial with individuals reporting high internal disinhibition showed significant differences in post-treatment weight change favoring Acceptance-Based Behavioral Intervention (ABBI) when compared to standard behavioral treatment (SBT). This paper examines process variables that might contribute to the observed differences in weight change. Methods: Participants were 162 adults with overweight or obesity (mean BMI 37.6) randomly assigned to ABBI or SBT...
October 2017: Journal of Contextual Behavioral Science
https://www.readbyqxmd.com/read/29221645/primary-care-led-weight-management-for-remission-of-type-2-diabetes-direct-an-open-label-cluster-randomised-trial
#20
Michael Ej Lean, Wilma S Leslie, Alison C Barnes, Naomi Brosnahan, George Thom, Louise McCombie, Carl Peters, Sviatlana Zhyzhneuskaya, Ahmad Al-Mrabeh, Kieren G Hollingsworth, Angela M Rodrigues, Lucia Rehackova, Ashley J Adamson, Falko F Sniehotta, John C Mathers, Hazel M Ross, Yvonne McIlvenna, Renae Stefanetti, Michael Trenell, Paul Welsh, Sharon Kean, Ian Ford, Alex McConnachie, Naveed Sattar, Roy Taylor
BACKGROUND: Type 2 diabetes is a chronic disorder that requires lifelong treatment. We aimed to assess whether intensive weight management within routine primary care would achieve remission of type 2 diabetes. METHODS: We did this open-label, cluster-randomised trial (DiRECT) at 49 primary care practices in Scotland and the Tyneside region of England. Practices were randomly assigned (1:1), via a computer-generated list, to provide either a weight management programme (intervention) or best-practice care by guidelines (control), with stratification for study site (Tyneside or Scotland) and practice list size (>5700 or ≤5700)...
December 4, 2017: Lancet
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