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https://www.readbyqxmd.com/read/28727546/a-formative-evaluation-of-a-diabetes-prevention-program-using-the-re-aim-framework-in-a-learning-health-care-system-utah-2013-2015
#1
Kimberly D Brunisholz, Jaewhan Kim, Lucy A Savitz, Mia Hashibe, Lisa H Gren, Sharon Hamilton, Kelly Huynh, Elizabeth A Joy
INTRODUCTION: Evaluation of interventions can help to close the gap between research and practice but seldom takes place during implementation. Using the RE-AIM framework, we conducted a formative evaluation of the first year of the Intermountain Healthcare Diabetes Prevention Program (DPP). METHODS: Adult patients who met the criteria for prediabetes (HbA1c of 5.70%-6.49% or fasting plasma glucose of 100-125 mg/dL) were attributed to a primary care provider from August 1, 2013, through July 31, 2014...
July 20, 2017: Preventing Chronic Disease
https://www.readbyqxmd.com/read/28725942/l-arginine-supplementation-prevents-allodynia-and-hyperalgesia-in-painful-diabetic-neuropathic-rats-by-normalizing-plasma-nitric-oxide-concentration-and-increasing-plasma-agmatine-concentration
#2
Lusliany J Rondón, M C Farges, N Davin, B Sion, A M Privat, M P Vasson, A Eschalier, C Courteix
PURPOSE: Neuropathic pain is a common diabetic complication. It is characterized by symptoms of spontaneous and stimulus-evoked pain including hyperalgesia and allodynia. L-Arginine is a common precursor of many metabolites of biological interest, in particular, nitric oxide (NO), ornithine, and hence polyamines. In central nervous system, NO, glutamate, and polyamines share an N-methyl-D-aspartate (NMDA) receptor-mediated effect. We hypothesized that a variation in arginine metabolism caused by diabetes may contribute to development and maintenance of neuropathic pain and to the worsening of clinical and biological signs of diabetes...
July 19, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28719083/subtypes-of-personality-and-locus-of-control-in-bariatric-patients-and-their-effect-on-weight-loss-eating-disorder-and-depressive-symptoms-and-quality-of-life
#3
Carolin Peterhänsel, Katja Linde, Birgit Wagner, Arne Dietrich, Anette Kersting
The present study subdivided personality types in a bariatric sample and investigated their impact on weight loss and psychopathology 6 and 12 months after surgery. One hundred thirty participants answered questionnaires on personality (NEO-FFI), 'locus of control' (IPC), depression severity (BDI-II), eating disorder psychopathology (EDE-Q), and health-related quality of life (HRQoL; SF-12). K-means cluster analyses were used to identify subtypes. Two subtypes emerged: an 'emotionally dysregulated/undercontrolled' cluster defined by high neuroticism and external orientation and a 'resilient/high functioning' cluster with the reverse pattern...
July 18, 2017: European Eating Disorders Review: the Journal of the Eating Disorders Association
https://www.readbyqxmd.com/read/28701540/a-novel-paraplegia-model-in-awake-behaving-macaques
#4
Max Ostrinsky Krucoff, Katie Zhuang, David B Macleod, Allen Yin, Yoon Woo Byun, Roberto Jose Manson, Dennis A Turner, Laura Oliveira, Mikhail A Lebedev
Lower limb paralysis from spinal cord injury (SCI) or neurological disease carries a poor prognosis for recovery and remains a large societal burden. Neurophysiological and neuroprosthetic research have the potential to improve quality of life for these patients; however, the lack of an ethical and sustainable non-human primate model for paraplegia hinders their advancement. Therefore, our multi-disciplinary team developed a way to induce temporary paralysis in awake behaving macaques by creating a fully implantable lumbar epidural catheter-subcutaneous port system that enables easy and reliable targeted drug delivery for sensorimotor blockade...
July 12, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28694840/hepatic-adipocyte-enteric-and-pancreatic-hormones-response-to-dietary-macronutrient-composition-and-relationship-with-metabolism
#5
Bridget M Hron, Cara B Ebbeling, Henry A Feldman, David S Ludwig
BACKGROUND: We sought to characterize the effects of dietary macronutrient composition on various hormones implicated in the regulation of insulin sensitivity (IS) and energy expenditure (EE). METHODS: Following 10-15% weight loss, 21 overweight subjects consumed 3 weight-loss maintenance diets [low fat (LF), low glycemic index (LGI) and very low carbohydrate (VLC)] in random order, each for 4 weeks. At baseline and at the end of each treatment period, fasting samples for fibroblast growth factor (FGF)-21, heme-oxygenase-1 (HO-1), chemerin, irisin, secreted frizzle-related protein (SFRP-4), total bile acids, ghrelin, gastrin inhibitory peptide (GIP), peptide-Y, and amylin; hepatic and peripheral IS; and EE were obtained...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28689920/relationship-between-weight-loss-in-obese-knee-osteoarthritis-patients-and-serum-biomarkers-of-cartilage-breakdown-secondary-analyses-of-a-randomised-trial
#6
E M Bartels, Y Henrotin, H Bliddal, P Centonze, M Henriksen
OBJECTIVE: To explore effects of weight loss and maintenance on serum cartilage biomarkers denaturation neoepitope for Collagen2 (Coll2-1) and Fibulin3 fragment (Fib3-2), as well as correlations between Coll2-1 and Fib3-2 and symptomatic improvement, in a knee osteoarthritis (KOA) population. DESIGN: 192 obese KOA patients followed a 16 week weight loss intervention and 52 weeks weight maintenance (ClinicalTrials.gov identifier: NCT00655941). Assessments were at 0, 8, 16 and 68 weeks...
July 6, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28689248/daily-self-weighing-and-weight-gain-prevention-a-longitudinal-study-of-college-aged-women
#7
Diane L Rosenbaum, Hallie M Espel, Meghan L Butryn, Fengqing Zhang, Michael R Lowe
Daily self-weighing has been suggested as an important factor for weight loss maintenance among samples with obesity. This study is a secondary analysis that examined daily self-weighing in association with weight and body composition outcomes over 2 years among young women with vulnerability for weight gain. Women (N = 294) of varying weight status completed self-weighing frequency questionnaires and weight was measured in the clinic at baseline, 6 months, 1, and 2 years; DXA scans were completed at baseline, 6 months and 2 years...
July 8, 2017: Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/28688102/how-to-switch-to-the-switch-implementation-of-biliopancreatic-diversion-with-duodenal-switch-into-practice
#8
Hamzeh M Halawani, Gintaras Antanavicius, Fernando Bonanni
The biliopancreatic diversion with duodenal switch (BPD/DS), a modification of the classic Scopinaro procedure, carries the highest rate of success in terms of weight loss, comorbid resolution, and maintenance of weight loss. The substantial challenges, technical complexity, and expected roadblocks of adding BPD/DS option to the bariatric surgeon's resources are reflected in the number of BPD/DS procedure performed in the USA, being less than 1% of all bariatric surgeries. Adjustments to the length of the common channel and the size of the vertical sleeve would increase the pool of candidates for BPD/DS and offer comprehensive management of obesity and metabolic comorbidities...
July 7, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28687371/body-weight-loss-effective-satiation-and-absence-of-homeostatic-neuropeptide-compensation-in-male-sprague-dawley-rats-schedule-fed%C3%A2-a-protein-crosslinked-diet
#9
Nikki Cassie, Richard L Anderson, Dana Wilson, Anne Pawsey, Julian G Mercer, Perry Barrett
Food structure contributes to the induction of satiation and the maintenance of satiety following intake of a meal. There is evidence from human studies that protein-crosslinking of a milk-protein based meal may enhance satiety, but the mechanism underpinning this effect is unknown. We investigated whether a rat model would respond in a similar manner and might provide mechanistic insight into enhanced satiety by structural modification of a food source. Rats were schedule fed a modified AIN-93M based diet in a liquid form or protein-crosslinked to produce a soft-solid form...
July 5, 2017: Appetite
https://www.readbyqxmd.com/read/28684917/effects-of-a-tailored-lifestyle-self-management-intervention-talent-study-on-weight-reduction-a-randomized-controlled-trial
#10
Dieter Melchart, Peter Löw, Erich Wühr, Victoria Kehl, Wolfgang Weidenhammer
OBJECTIVE: Overweight and obesity are globally increasing risk factors for diseases in the context of metabolic syndrome. A randomized controlled trial was conducted to investigate whether there are any existing differences between two lifestyle intervention strategies with respect to weight reduction after 1 year. SUBJECTS AND METHODS: A total of 166 subjects with a body mass index of 28-35 kg/m(2) were enrolled in this trial at seven study centers; 109 were randomly allocated to the intervention group (comprehensive lifestyle modification program: web-based Individual Health Management [IHM]) with 3-month reduction phase plus 9-month maintenance phase, and 57 were allocated to the control group (written information with advice for healthy food habits: usual care [UC])...
2017: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/28679554/protein-supplements-after-weight-loss-do-not-improve-weight-maintenance-compared-with-recommended-dietary-protein-intake-despite-beneficial-effects-on-appetite-sensation-and-energy-expenditure-a-randomized-controlled-double-blinded-trial
#11
Louise Kjølbæk, Lone Brinkmann Sørensen, Nadja Buus Søndertoft, Carrie Klestrup Rasmussen, Janne Kunchel Lorenzen, Anja Serena, Arne Astrup, Lesli Hingstrup Larsen
Background: High-protein diets increase weight loss (WL) during energy restriction; therefore, it has been suggested that additional protein intake may improve weight maintenance (WM) after WL.Objective: We investigated the effect of protein supplements from either whey with or without calcium or soy on WM success after WL compared with that of a control.Design: In a randomized, controlled, double-blinded trial, 220 participants aged 18-60 y with body mass index (in kg/m(2)) from 27.6 to 40.4 were included...
July 5, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28679551/pretreatment-fasting-plasma-glucose-and-insulin-modify-dietary-weight-loss-success-results-from-3-randomized-clinical-trials
#12
Mads F Hjorth, Christian Ritz, Ellen E Blaak, Wim Hm Saris, Dominique Langin, Sanne Kellebjerg Poulsen, Thomas Meinert Larsen, Thorkild Ia Sørensen, Yishai Zohar, Arne Astrup
Background: Which diet is optimal for weight loss and maintenance remains controversial and implies that no diet fits all patients.Objective: We studied concentrations of fasting plasma glucose (FPG) and fasting insulin (FI) as prognostic markers for successful weight loss and maintenance through diets with different glycemic loads or different fiber and whole-grain content, assessed in 3 randomized trials of overweight participants.Design: After an 8-wk weight loss, participants in the DiOGenes (Diet, Obesity, and Genes) trial consumed ad libitum for 26 wk a diet with either a high or a low glycemic load...
July 5, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28679529/timing-of-caloric-intake-during-weight-loss-differentially-affects-striatal-dopamine-transporter-and-thalamic-serotonin-transporter-binding
#13
Ruth I Versteeg, Anouk Schrantee, Sofie M Adriaanse, Unga A Unmehopa, Jan Booij, Liesbeth Reneman, Eric Fliers, Susanne E la Fleur, Mireille J Serlie
Recent studies have shown that meal timing throughout the day contributes to maintaining or regaining weight after hypocaloric diets. Although brain serotonin and dopamine are well known to be involved in regulating feeding, it is unknown whether meal timing during energy restriction affects these neurotransmitter systems. We studied the effect of a 4 wk hypocaloric diet with either 50% of daily calories consumed at breakfast (BF group) or at dinner (D group) on hypothalamic and thalamic serotonin transporter (SERT) binding and on striatal dopamine transporter (DAT) binding...
July 5, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28676320/body-contouring-procedures-in-three-or-more-anatomical-areas-are-associated-with-long-term-body-mass-index-decrease-in-massive-weight-loss-patients-a-retrospective-cohort-study
#14
Itay Wiser, Lior Heller, Coral Spector, Ehud Fliss, Tali Friedman
BACKGROUND: Massive weight loss (MWL) patients who undergo body contouring plastic surgery (BCPS) display superior long-term weight maintenance. The effect of the number of anatomical areas contoured on weight dynamics is undetermined. OBJECTIVES: To determine whether body mass index (BMI) dynamics following BCPS are associated with the number of anatomical areas operated. METHODS: A retrospective cohort study was conducted. Study groups were defined by the number of anatomical areas operated (1, 2, and 3+)...
June 9, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28668276/a-walking-intervention-among-men-with-prostate-cancer-a-pilot-study
#15
Claire H Pernar, Katja Fall, Jennifer R Rider, Sarah C Markt, Hans-Olov Adami, Sven-Olof Andersson, Unnur Valdimarsdottir, Ove Andrén, Lorelei A Mucci
BACKGROUND: Men diagnosed with prostate cancer have increased risk for disease progression, cardiovascular events, and impairments in quality of life. This pilot study evaluated the feasibility of a randomized walking group intervention to improve quality of life, circulating biomarkers, and morbidity among men with newly diagnosed prostate cancer. METHODS: Men were recruited at Örebro University Hospital, Sweden, and randomized to an 11-week walking group intervention (n = 21) or usual care (n = 20)...
May 31, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28664540/maintenance-diets-following-rapid-weight-loss-in-obstructive-sleep-apnea-a-pilot-1-year-clinical-trial
#16
Elizabeth A Cayanan, Nathaniel S Marshall, Camilla M Hoyos, Craig L Phillips, Yasmina Serinel, Keith K H Wong, Brendon J Yee, Ronald R Grunstein
Very low energy diets (VLED) appear to be the most efficacious dietary-based obesity reduction treatments in obstructive sleep apnea (OSA); however, effective weight loss maintenance strategies remain untested in this condition. Our study aimed to assess the feasibility, tolerability and efficacy of two common maintenance diets during a 10-month follow-up period after rapid weight loss using a 2-month VLED. In this two-arm, single-centre, open-label pilot trial, obese adult OSA patients received a 2-month VLED before being allocated to either the Australian Guide to Healthy Eating diet (AGHE) or a low glycaemic index high-protein diet (LGHP)...
June 30, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28662287/weight-management-a-concept-analysis
#17
Connie L Winik, C Elizabeth Bonham
AIM: There is a need to develop sound healthcare practices where patients and providers are able to succeed in meeting weight management goals. The aim of this analysis is to develop a better understanding the concept of weight management. BACKGROUND: Obesity is a rapidly growing healthcare issue, reaching epidemic levels around the world. According to the World Health Organization, the current incident rate of obesity makes it the leading risk for death across the globe...
June 29, 2017: Nursing Forum
https://www.readbyqxmd.com/read/28656645/regulation-of-nuclear-receptor-interacting-protein-1-nrip1-gene-expression-in-response-to-weight-loss-and-exercise-in-humans
#18
Yang De Marinis, Jiangming Sun, Pradeep Bompada, Judit Domènech Omella, Cheng Luan, Arda Halu, Erik Renström, Amitabh Sharma, Martin Ridderstråle
OBJECTIVE: Nuclear receptor interacting protein 1 (NRIP1) is an important energy regulator, but few studies have addressed its role in humans. This study investigated adipose tissue and skeletal muscle NRIP1 gene expression and serum levels in response to weight loss and exercise in humans. METHODS: NRIP1 expression was measured by microarray and serum NRIP1 by ELISA and Western blotting. Skeletal muscle transcriptomes were analyzed from Gene Expression Omnibus databases...
June 28, 2017: Obesity
https://www.readbyqxmd.com/read/28652225/web-based-interventions-for-weight-loss-or-weight-loss-maintenance-in-overweight-and-obese-people-a-systematic-review-of-systematic-reviews
#19
REVIEW
Angela Sorgente, Giada Pietrabissa, Gian Mauro Manzoni, Federica Re, Susan Simpson, Sara Perona, Alessandro Rossi, Roberto Cattivelli, Marco Innamorati, Jeffrey B Jackson, Gianluca Castelnuovo
BACKGROUND: Weight loss is challenging and maintenance of weight loss is problematic. Web-based programs offer good potential for delivery of interventions for weight loss or weight loss maintenance. However, the precise impact of Web-based weight management programs is still unclear. OBJECTIVE: The purpose of this meta-systematic review was to provide a comprehensive summary of the efficacy of Web-based interventions for weight loss and weight loss maintenance...
June 26, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28647001/gastric-bypass-surgery-stimulates-the-dormant-gut-brain-axis-in-obesity
#20
Stephanie P B Caligiuri, Paul J Kenny
To truly reduce the rates of chronic kidney disease, a root cause of kidney damage, obesity, must be targeted. Weight loss is often unsustainable because imbalances in satiety regulators are frequently not addressed to ensure maintenance of weight loss. In a recent study, gastric bypass surgery rebalanced satiety signals through resensitization of the gut-brain axis in obesity. This research may lead to noninvasive strategies to reduce obesity and obesity-related kidney disease.
July 2017: Kidney International
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