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https://www.readbyqxmd.com/read/28209193/up601-a-standardized-botanical-composition-composed-of-morus-alba-yerba-mate-and-magnolia-officinalis-for-weight-loss
#1
Mesfin Yimam, Ping Jiao, Mei Hong, Lidia Brownell, Young-Chul Lee, Eu-Jin Hyun, Hyun-Jin Kim, Jeong-Bum Nam, Mi-Ran Kim, Qi Jia
BACKGROUND: The prevalence of obesity is surging in an alarming rate all over the world. Pharmaceutical drugs are considered potential adjunctive therapy to lifestyle modification. However, for most, besides being too expensive, their long term usages are hindered by their severe adverse effects. Here we describe the effect of UP601, a standardized blend of extracts from Morus alba, Yerba mate and Magnolia officinalis, in modulating a number of obesity-related phenotypic and biochemical markers in a high-fat high-fructose (HFF)-induced C57BL/6J mouse model of obesity...
February 16, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28202029/sustained-diabetes-risk-reduction-after-real-life-and-primary-health-care-setting-implementation-of-the-diabetes-in-europe-prevention-using-lifestyle-physical-activity-and-nutritional-intervention-de-plan-project
#2
Aleksandra Gilis-Januszewska, Jaana Lindström, Jaakko Tuomilehto, Beata Piwońska-Solska, Roman Topór-Mądry, Zbigniew Szybiński, Markku Peltonen, Peter E H Schwarz, Adam Windak, Alicja Hubalewska-Dydejczyk
BACKGROUND: Real life implementation studies performed in different settings and populations proved that lifestyle interventions in prevention of type 2 diabetes can be effective. However, little is known about long term results of these translational studies. Therefore, the purpose of this study was to examine the maintenance of diabetes type 2 risk factor reduction achieved 1 year after intervention and during 3 year follow-up in primary health care setting in Poland. METHODS: Study participants (n = 262), middle aged, slightly obese, with increased type 2 diabetes risk ((age 55...
February 15, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28197827/phloretin-prevents-high-fat-diet-induced-obesity-and-improves-metabolic-homeostasis
#3
Sary Alsanea, Mingming Gao, Dexi Liu
Reactive oxygen species generated as a by-product in metabolism play a central role in the development of obesity and obesity-related metabolic complications. The objective of the current study is to explore the possibility to block obesity and improve metabolic homeostasis via phloretin, a natural antioxidant product from apple tree leaves and Manchurian apricot. Both preventive and therapeutic activities of phloretin were assessed using a high-fat diet-induced obesity mouse model. Phloretin was injected intraperitoneally twice weekly into regular and obese mice fed a high-fat diet...
February 14, 2017: AAPS Journal
https://www.readbyqxmd.com/read/28194046/morinda-citrifolia-noni-fruit-juice-reduces-inflammatory-cytokines-expression-and-contributes-to-the-maintenance-of-intestinal-mucosal-integrity-in-dss-experimental-colitis
#4
Beatriz Coutinho de Sousa, Juliana Reis Machado, Marcos Vinicius da Silva, Thiago Alvares da Costa, Javier Emilio Lazo-Chica, Thatiane do Prado Degasperi, Virmondes Rodrigues Junior, Helioswilton Sales-Campos, Elizabeth Uber Bucek, Carlo José Freire Oliveira
Morinda citrifolia L. (noni) has been shown to treat different disorders. However, data concerning its role in the treatment of intestinal inflammation still require clarification. In the current study, we investigated the effects of noni fruit juice (NFJ) in the treatment of C57BL/6 mice, which were continuously exposed to dextran sulfate sodium (DSS) for 9 consecutive days. NFJ consumption had no impact on the reduction of the clinical signs of the disease or on weight loss. Nonetheless, when a dilution of 1 : 10 was used, the intestinal architecture of the mice was preserved, accompanied by a reduction in the inflammatory infiltrate...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28192109/intensive-lifestyle-intervention-for-obesity-principles-practices-and-results
#5
Victoria L Webb, Thomas A Wadden
Using the Guidelines for the Management of Overweight and Obesity in Adults as a framework, this article reviews intensive lifestyle interventions for weight loss. The Guidelines recommend a minimum of 6 months of high-intensity, comprehensive lifestyle intervention, consisting of a reduced-calorie diet, increased physical activity, and behavior therapy. Persons with obesity typically lose about 8 kg (approximately 8% of initial weight) with this approach, accompanied by improvements in health and quality of life...
February 9, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28184001/igfbp-4-regulates-adult-skeletal-growth-in-a-sex-specific-manner
#6
David E Maridas, Victoria E DeMambro, Phuong T Le, Subburaman Mohan, Cliff Rosen
Insulin-like growth factor-1 (IGF-1) and its binding proteins are critical mediators of skeletal growth. Insulin-like Growth Factor Binding Protein 4 (IGFBP-4) is highly expressed in osteoblasts and inhibits IGF-1 actions in vitro. Yet, in vivo studies suggest that it could potentiate IGF-1 and IGF-2 actions. In this study, we hypothesized that IGFBP-4 might potentiate the actions of IGF-1 on the skeleton. To test this, we comprehensively studied 8 and 16-week-old Igfbp4-/- mice. Both male and female adult Igfbp4-/- mice had marked growth retardation with reductions in body weight, body and femur lengths, fat proportion and lean mass at 8 and 16 weeks...
February 9, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28179223/substituting-whole-grains-for-refined-grains-in-a-6-wk-randomized-trial-favorably-affects-energy-balance-metrics-in-healthy-men-and-postmenopausal-women
#7
J Philip Karl, Mohsen Meydani, Junaidah B Barnett, Sally M Vanegas, Barry Goldin, Anne Kane, Helen Rasmussen, Edward Saltzman, Pajau Vangay, Dan Knights, C-Y Oliver Chen, Sai Krupa Das, Satya S Jonnalagadda, Simin N Meydani, Susan B Roberts
Background: The effect of whole grains on the regulation of energy balance remains controversial.Objective: We aimed to determine the effects of substituting whole grains for refined grains, independent of body weight changes, on energy-metabolism metrics and glycemic control.Design: The study was a randomized, controlled, parallel-arm controlled-feeding trial that was conducted in 81 men and postmenopausal women [49 men and 32 women; age range: 40-65 y; body mass index (in kg/m(2)): <35.0]. After a 2-wk run-in period, participants were randomly assigned to consume 1 of 2 weight-maintenance diets for 6 wk...
February 8, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28170168/early-post-operative-psychosocial-and-weight-predictors-of-later-outcome-in-bariatric-surgery-a-systematic-literature-review
#8
REVIEW
A Hindle, X de la Piedad Garcia, L Brennan
This is the first systematic review to synthesize the evidence concerning early post-operative variables predictive of later weight and psychosocial outcomes in bariatric surgery. Eight electronic databases for empirical studies were searched (1954 to 2016). Most of the 39 included studies reported solely on weight outcomes; eating and psychosocial outcomes were less common. A better early weight loss trajectory was the most consistent predictor of more successful medium-term weight outcome (≤24 months); however, its relationship to longer term weight loss maintenance is less certain...
March 2017: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28166764/impact-of-weight-maintenance-and-loss-on-diabetes-risk-and-burden-a-population-based-study-in-33-184-participants
#9
Adina L Feldman, Simon J Griffin, Amy L Ahern, Grainne H Long, Lars Weinehall, Eva Fhärm, Margareta Norberg, Patrik Wennberg
BACKGROUND: Weight loss in individuals at high risk of diabetes is an effective prevention method and a major component of the currently prevailing diabetes prevention strategies. The aim of the present study was to investigate the public health potential for diabetes prevention of weight maintenance or moderate weight loss on a population level in an observational cohort with repeated measurements of weight and diabetes status. METHODS: Height, weight and diabetes status were objectively measured at baseline and 10 year follow-up in a population-based cohort of 33,184 participants aged 30-60 years between 1990 and 2013 in Västerbotten County, Sweden...
February 6, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28164457/isometric-thermogenesis-at-rest-and-during-movement-a-neglected-variable-in-energy-expenditure-and-obesity-predisposition
#10
REVIEW
A G Dulloo, J L Miles-Chan, J-P Montani, Y Schutz
Isometric thermogenesis as applied to human energy expenditure refers to heat production resulting from increased muscle tension. While most physical activities consist of both dynamic and static (isometric) muscle actions, the isometric component is very often essential for the optimal performance of dynamic work given its role in coordinating posture during standing, walking and most physical activities of everyday life. Over the past 75 years, there has been sporadic interest into the relevance of isometric work to thermoregulatory thermogenesis and to adaptive thermogenesis pertaining to body-weight regulation...
February 2017: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28160229/executive-function-in-weight-loss-and-weight-loss-maintenance-a-conceptual-review-and-novel-neuropsychological-model-of-weight-control
#11
REVIEW
Katelyn M Gettens, Amy A Gorin
Weight loss maintenance is a complex, multifaceted process that presents a significant challenge for most individuals who lose weight. A growing body of literature indicates a strong relationship between cognitive dysfunction and excessive body weight, and suggests that a subset of high-order cognitive processes known as executive functions (EF) likely play an important role in weight management. Recent reviews cover neuropsychological correlates of weight status yet fail to address the role of executive function in the central dilemma of successful weight loss maintenance...
February 3, 2017: Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/28152191/long-term-weight-loss-maintenance-in-obesity-possible-insights-from-anorexia-nervosa
#12
Loren M Gianini, B Timothy Walsh, Joanna Steinglass, Laurel Mayer
No abstract text is available yet for this article.
February 2, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28151049/effect-of-co-culture-of-mesenchymal-stem-stromal-cells-with-pancreatic-islets-on-viability-and-function-outcomes-a-systematic-review-and-meta-analysis
#13
Bianca Marmontel de Souza, Ana Paula Bouças, Fernanda Dos Santos de Oliveira, Karina Pires Reis, Patrícia Ziegelmann, Andrea Carla Bauer, Daisy Crispim
The maintenance of viable and functional pancreatic islets is crucial for successful islet transplantation from brain-dead donors. To overcome islet quality loss during culture, some studies have co-cultured islets with mesenchymal stem/stromal cells (MSC). However, it is still uncertain if MSC-secreted factors are enough to improve islet quality or if a physical contact between MSCs and islets is needed. Therefore, we performed a systematic review and meta-analysis to clarify the effect of different culture contact systems of islets with MSCs on viability and insulin secretion outcomes...
February 2, 2017: Islets
https://www.readbyqxmd.com/read/28150402/could-habits-hold-the-key-to-weight-loss-maintenance-a-narrative-review
#14
REVIEW
G Cleo, E Isenring, R Thomas, P Glasziou
Despite the significance placed on lifestyle interventions for obesity management, most weight loss is followed by weight regain. Psychological concepts of habitual behaviour and automaticity have been suggested as plausible explanations for this overwhelming lack of long-term weight loss success. Interventions that focus on changing an individual's behaviour are not usually successful at changing an individual's habits because they do not incorporate the strategies required to break unhealthy habits and/or form new healthy habits...
February 2, 2017: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/28128659/remifentanil-reduces-blood-loss-during-orthognathic-surgery
#15
Nobuyuki Matsuura, Taiki Okamura, Satoko Ide, Tatsuya Ichinohe
Remifentanil is reported to reduce oral tissue blood flow. We performed a retrospective investigation using logistic regression analysis of anesthesia records to investigate whether the use of remifentanil infusion in a balanced anesthesia technique was useful as a primary technique to reduce blood loss during orthognathic surgery. Subjects were 80 patients who underwent Le Fort I osteotomy and sagittal split ramus osteotomy of the mandible. The variables included gender, age, weight, type of maintenance anesthetic, type and dose or infusion rate of opioid, mean systolic blood pressure (SBP-mean), coefficient of variation of systolic blood pressure (CVSBP) during surgery, mean heart rate (HR-mean), duration of surgery, total blood loss, volume of infusion used, amount of local anesthetic used, body temperature, and urine output...
2017: Anesthesia Progress
https://www.readbyqxmd.com/read/28125565/efficacy-of-a-physician-assistant-student-developed-behavior-change-program-at-a-local-free-clinic
#16
Judy Cusumano, Carla S Martin, Brittany Butler, Brian Bixler, Kelsey Shirk
PURPOSE: A quality assurance and quality improvement assessment was conducted to evaluate the efficacy of a behavior change program developed by physician assistant (PA) students at a local free clinic. METHODS: Physician assistant students developed and implemented a program using motivational interviewing and healthy lifestyle behavioral counseling at a local free clinic. Twenty-eight patients participated in the program over 5 cohorts. A retrospective chart review was used to collect data...
March 2017: Journal of Physician Assistant Education
https://www.readbyqxmd.com/read/28125552/o-004-application-of-population-pharmacokinetic-modeling-to-develop-individualized-infliximab-dosing-strategies-in-pediatric-crohn-s-disease
#17
Adam Frymoyer, Daniel Hoekman, Tim de Meij, Thalia Hummel, Marc Benninga, Angelika Kindermann, Travis Piester, K T Park
BACKGROUND: Adequate infliximab (IFX) exposure is critical when treating Crohn's disease (CD), and trough concentrations <3 μg/mL are associated with loss of response. However, the pharmacokinetics of IFX are highly variable in children with CD, and this has made IFX dosing challenging in this population. Model-based drug dosing offers the potential for developing individualized dosing strategies. The objective of the current study was to evaluate the predictive performance and clinical utility of a previously published population pharmacokinetic model of IFX when applied to children with CD...
February 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28124856/are-adults-attending-gps-able-to-check-their-own-weight
#18
M Crickmer, M Johnson, E Shanahan, B O'Shea
Studies have shown self-weighing behaviour is associated with weight loss and maintenance of previous losses. In this cross-sectional survey of 151 patients, 98 (65.0%) participants were overweight or obese, and 59 (31.9%) participants did not self-weigh. Healthcare teams should advise patients on weighing practices to control obesity.
September 9, 2016: Irish Medical Journal
https://www.readbyqxmd.com/read/28122658/randomised-controlled-trial-and-economic-analysis-of-an-internet-based-weight-management-programme-power-positive-online-weight-reduction
#19
Paul Little, Beth Stuart, Fd Richard Hobbs, Jo Kelly, Emily R Smith, Katherine J Bradbury, Stephanie Hughes, Peter Wf Smith, Michael V Moore, Mike Ej Lean, Barrie M Margetts, Christopher D Byrne, Simon Griffin, Mina Davoudianfar, Julie Hooper, Guiqing Yao, Shihua Zhu, James Raftery, Lucy Yardley
BACKGROUND: Behavioural counselling with intensive follow-up for obesity is effective, but in resource-constrained primary care settings briefer approaches are needed. OBJECTIVES: To estimate the clinical effectiveness and cost-effectiveness of an internet-based behavioural intervention with regular face-to-face or remote support in primary care, compared with brief advice. DESIGN: Individually randomised three-arm parallel trial with health economic evaluation and nested qualitative interviews...
January 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28119466/effects-of-the-dietary-protein-and-carbohydrate-ratio-on-gut-microbiomes-in-dogs-of-different-body-conditions
#20
Qinghong Li, Christian L Lauber, Gail Czarnecki-Maulden, Yuanlong Pan, Steven S Hannah
: Obesity has become a health epidemic in both humans and pets. A dysbiotic gut microbiota has been associated with obesity and other metabolic disorders. High-protein, low-carbohydrate (HPLC) diets have been recommended for body weight loss, but little is known about their effects on the canine gut microbiome. Sixty-three obese and lean Labrador retrievers and Beagles (mean age, 5.72 years) were fed a common baseline diet for 4 weeks in phase 1, followed by 4 weeks of a treatment diet, specifically, the HPLC diet (49...
January 24, 2017: MBio
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