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https://www.readbyqxmd.com/read/27927847/preserved-seminiferous-tubule-integrity-with-spermatogonial-survival-and-induction-of-sertoli-and-leydig-cell-maturation-after-long-term-organotypic-culture-of-prepubertal-human-testicular-tissue
#1
F de Michele, J Poels, L Weerens, C Petit, Z Evrard, J Ambroise, D Gruson, C Wyns
STUDY QUESTION: Is an organotypic culture system able to provide the appropriate testicular microenvironment for in-vitro maturation of human immature testicular tissue (ITT)? SUMMARY ANSWER: Our organotypic culture system provided a microenvironment capable of preserving seminiferous tubule (ST) integrity and Leydig cell (LC) functionality and inducing Sertoli cell (SC) maturation. WHAT IS KNOWN ALREADY: Cryopreservation of human ITT is a well-established strategy to preserve fertility in prepubertal boys affected by cancer, with a view for obtaining sperm...
December 6, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27907901/serum-amh-levels-in-healthy-women-from-brca1-2-mutated-families-are-they-reduced
#2
Theodora C van Tilborg, Inge A P Derks-Smeets, Anna M E Bos, Jan C Oosterwijk, Ron J van Golde, Christine E de Die-Smulders, Lizet E van der Kolk, Wendy A G van Zelst-Stams, Maria E Velthuizen, Annemieke Hoek, Marinus J C Eijkemans, Joop S E Laven, Margreet G E M Ausems, Frank J M Broekmans
STUDY QUESTION: Do BRCA1/2 mutation carriers have a compromised ovarian reserve compared to proven non-carriers, based on serum anti-Müllerian hormone (AMH) levels? SUMMARY ANSWER: BRCA1/2 mutation carriers do not show a lower serum AMH level in comparison to proven non-carriers, after adjustment for potential confounders. WHAT IS KNOWN ALREADY: It has been suggested that the BRCA genes play a role in the process of ovarian reserve depletion, although previous studies have shown inconsistent results regarding the association between serum AMH levels and BRCA mutation status...
November 2016: Human Reproduction
https://www.readbyqxmd.com/read/27871721/roles-of-human-epididymis-protein-4-carbohydrate-antigen-125-inhibin-b-and-anti-m%C3%A3-llerian-hormone-in-the-differential-diagnosis-and-follow-up-of-ovarian-granulosa-cell-tumors
#3
Ulla-Maija Haltia, Marianne Hallamaa, Johanna Tapper, Johanna Hynninen, Henrik Alfthan, Bhanu Kalra, Olli Ritvos, Markku Heikinheimo, Leila Unkila-Kallio, Antti Perheentupa, Anniina Färkkilä
OBJECTIVE: Evaluation of circulating tumor markers in ovarian cancer is crucial for optimal patient care. The goal of this study was to verify the most accurate circulating tumor markers for the diagnosis and follow-up of adult-type granulosa cell tumors (AGCTs). METHODS: The levels of circulating human epididymis protein 4 (HE4) and carbohydrate antigen 125 (CA125), together with AGCT markers inhibin B and anti-Müllerian hormone (AMH), were measured in 135 samples from AGCT patients, 37 epithelial ovarian carcinoma (EOC) patients, and 40 endometrioma (ENDO) patients...
November 18, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27821706/longitudinal-follow-up-in-female-childhood-cancer-survivors-no-signs-of-accelerated-ovarian-function-loss
#4
A L F van der Kooi, M M van den Heuvel-Eibrink, A van Noortwijk, S J C M M Neggers, S M F Pluijm, E van Dulmen-den Broeder, W van Dorp, J S E Laven
STUDY QUESTION: Is the long-term decline of ovarian function, as reflected by a decrease in serum anti-Müllerian hormone (AMH) concentration, accelerated over time in female childhood cancer survivors (CCS) as compared to healthy women of the same age? SUMMARY ANSWER: The median decline of AMH levels in long-term female CCS is not accelerated and similar to that observed in healthy controls. WHAT IS KNOWN ALREADY: Gonadal function is compromised in female CCS treated with chemotherapy and/or radiation therapy...
November 7, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27819640/mature-teratoma-associated-with-bilateral-ovarian-carcinosarcoma-accidental-association-or-etiopathogenetic-determinism-case-report
#5
Rodica Birla, Elena-Roxana Catanescu, Andrei Caragui, Silviu Constantinoiu
Carcinosarcoma is a rare form of ovarian cancer with mixed origin, and its association with mature teratoma is extremely rare. We present the case of patient T. M. aged 67, admitted into our clinic on the 15/05/2016, F.O. 4877 for the increase of the abdominal volume. On admission, the patient was afebrile, conscious, cooperative, cardio-respiratory balanced, having the abdomen distended in volume, sharp dullness in the flanks, positive wave sign bioumoral within normal limits except: uric acid = 6.64 mg / dL, serum glucose = 113...
2016: Chirurgia
https://www.readbyqxmd.com/read/27801734/pd-l1-expression-in-carcinosarcomas-of-the-gynecologic-tract-a-potentially-actionable-biomarker
#6
Andre Pinto, Nicholas Mackrides, Mehrdad Nadji
BACKGROUND: Carcinosarcomas of the gynecologic tract, also known as malignant mixed Müllerian tumors, are aggressive neoplasms with a high recurrence rate and poor prognosis. Despite advances in adjuvant therapies in recent years, the prognosis of these tumors has not improved. In fact, there are currently no consensus guidelines for the treatment of these neoplasms and the search for targetable biomarkers has not been successful so far. Programmed death-ligand 1 (PD-L1) has emerged as a potential target for therapeutics in a number of malignant tumors, including melanoma, lung, and colorectal cancer...
October 31, 2016: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/27785439/malignancy-in-disorders-of-sex-development
#7
REVIEW
Martin Kathrins, Thomas F Kolon
Disorders of sex development (DSD) represent a spectrum of conditions in which chromosomal, gonadal, or anatomic sex are atypical and affect 1 in 4,500-5,000 live births. The diagnosis of DSD raises concerns of tumor risk and treatment as well as future fertility preservation. We review the current understanding of the types of gonadal tumors that arise in DSD patients as well as possible markers and treatment. The goal is to inform the members of the DSD team (urologist, endocrinologist, geneticist, psychologist) of the latest findings regarding malignancy in DSD...
October 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/27780981/longitudinal-observation-of-serum-anti-m%C3%A3-llerian-hormone-in-three-girls-after-cancer-treatment
#8
Yoko Miyoshi, Kie Yasuda, Makiko Tachibana, Hisao Yoshida, Emiko Miyashita, Takako Miyamura, Yoshiko Hashii, Kae Hashimoto, Tadashi Kimura, Keiichi Ozono
Gonadal dysfunction and infertility are major endocrinological late effects among childhood cancer survivors. Chemotherapy and radiation have gonadotoxic effects and diminish the ovarian reserve. The serum concentration of anti-Müllerian hormone (AMH) is a useful marker of ovarian reserve in survivors. We conducted a longitudinal study to investigate the variations of AMH in evaluating the acute and chronic effects of cancer therapy on the ovary. Three young female patients with different hematological diseases were registered, and their medical records were reviewed...
October 2016: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
https://www.readbyqxmd.com/read/27771166/survival-of-women-with-mullerian-adenosarcoma-a-national-cancer-data-base-study
#9
Brandon-Luke L Seagle, Margaux Kanis, Anna E Strohl, Shohreh Shahabi
OBJECTIVE: To determine overall survival (OS) and factors associated with OS of women with Mullerian adenosarcoma. METHODS: Women with adenosarcoma of the uterus, cervix or ovary (n=2205) were identified from the 1998-2011 National Cancer Data Base. Kaplan-Meier and multivariate Cox proportional-hazards survival analyses were performed to test for associations of potential explanatory variables with OS. A subset analysis of women with uterine adenosarcoma was also performed...
December 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27770810/systematic-assessment-of-her2-neu-in-gynecologic-neoplasms-an-institutional-experience
#10
Jennifer S Woo, Sophia K Apple, Peggy S Sullivan, Jian-Yu Rao, Nora Ostrzega, Neda A Moatamed
BACKGROUND: HER2/neu overexpression and/or amplification has been widely studied in a number of solid tumors, primarily in the breast. In gynecologic neoplasms, determination of HER2/neu status has not been well studied as a predictive biomarker in anti-HER2/neu treatment. METHODS: We systematically evaluated the HER2/neu reactions by immunohistochemistry and fluorescent in situ hybridization in malignant gynecologic neoplasms as experienced in our institution. RESULTS: The HER2/neu overexpression or amplification occurred in 8 % of the cancers of the gynecological organs in our series...
October 22, 2016: Diagnostic Pathology
https://www.readbyqxmd.com/read/27711957/evaluation-of-ovarian-reserve-with-amh-level-in-patients-with-well-differentiated-thyroid-cancer-receiving-radioactive-iodine-ablation-treatment
#11
F Acıbucu, D O Acıbucu, Ö B Akkar, H S Dokmetas
Introduction: Radioactive iodine (RAI) ablation treatment is used for patients diagnosed with well-differentiated thyroid cancer in order to reduce the risk of recurrence. RAI ablation treatment can adversely affect gonads in males and females. In this study, we aimed to determine ovary damage and infertility risk due to RAI, using serum anti-Müllerian hormone (AMH) level, in females who received RAI ablation treatment. Materials and Methods: 45 female patients who have not gone through the menopause and had received RAI ablation treatment for well-differentiated thyroid cancer in premenopausal period, and 40 healthy females as control groups were included in this study...
November 2016: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/27680667/immunophenotyping-of-rabbit-testicular-germ-and-sertoli-cells-across-maturational-stages
#12
B Banco, G Grilli, C Giudice, A Tomas Marques, S Cotti Cometti, G Visigalli, V Grieco
During testicular maturation, both Sertoli cells (SCs) and germ cells (GCs) switch from an immature to a mature immunophenotype. The reexpression of markers of immaturity in adults has been reported in cancer and in other testicular pathologies, in men as well as in animal species. Naturally affected with testicular cancer, rabbits have long been used in human reproductive research, but reports on the expression of testicular cell markers in this species are few and data about the immunophenotype of normal postnatal SCs and GCs are lacking...
September 28, 2016: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
https://www.readbyqxmd.com/read/27677176/successful-delivery-in-a-39-year-old-patient-with-anal-cancer-after-fertility-preserving-surgery-followed-by-primary-chemoradiation-and-low-anti-mullerian-hormone-level
#13
Christhardt Köhler, Simone Marnitz, Peter Biel, Tim Cordes
Anal cancer was diagnosed in a 36-year-old nulliparous woman. Before chemoradiation was started, ovarian transposition and uterine fixation were performed in order to preserve capability for future parenthood. Despite of a low anti-Mullerian hormone level, IVF therapy was successful and resulted in a full-term delivery of a healthy baby by cesarean section. This is the first case report of successful pregnancy after full-dose pelvic radiation for anal cancer.
September 28, 2016: Oncology
https://www.readbyqxmd.com/read/27664208/factors-associated-with-ovarian-function-recovery-after-chemotherapy-for-breast-cancer-a-systematic-review-and-meta-analysis
#14
Cristina Silva, Olga Caramelo, Teresa Almeida-Santos, Ana Cristina Ribeiro Rama
STUDY QUESTION: Which factors related to patient, treatment or disease are associated with ovarian function recovery after chemotherapy in premenopausal women with breast cancer? SUMMARY ANSWER: Younger age and GnRH agonist (GnRHa) administration during chemotherapy were significantly associated with menses recovery, but this recovery was less likely in patients exposed to taxanes. WHAT IS ALREADY KNOWN: To date, published meta-analyses have only assessed GnRHa administration as a possible factor for ovarian function recovery, and their results were conflicting...
December 2016: Human Reproduction
https://www.readbyqxmd.com/read/27621194/3-to-5%C3%A2-years-later-long-term-effects-of-prophylactic-bilateral-salpingectomy-on-ovarian-function
#15
Roberta Venturella, Daniela Lico, Massimo Borelli, Maria G Imbrogno, Gabriele Cevenini, Errico Zupi, Fulvio Zullo, Michele Morelli
STUDY OBJECTIVE: Preliminary data on the effects of prophylactic bilateral salpingectomy (PBS) show that postoperative ovarian function is preserved up to 3 months after surgery. The confirmation of PBS safety on ovarian function even many years after surgery is essential to reassure the medical community that this new strategy, recently proposed for the prevention of ovarian cancer, is at least able to avoid the risk of premature surgical menopause. We investigated whether the addition of PBS during total laparoscopic hysterectomy (TLH) causes long-term effects on ovarian function...
September 13, 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27617304/epigenetic-remodeling-regulates-transcriptional-changes-between-ovarian-cancer-and-benign-precursors
#16
Kevin M Elias, Megan M Emori, Thomas Westerling, Henry Long, Anna Budina-Kolomets, Fugen Li, Emily MacDuffie, Michelle R Davis, Alexander Holman, Brian Lawney, Matthew L Freedman, John Quackenbush, Myles Brown, Ronny Drapkin
Regulation of lineage-restricted transcription factors has been shown to influence malignant transformation in several types of cancer. Whether similar mechanisms are involved in ovarian cancer pathogenesis is unknown. PAX8 is a nuclear transcription factor that controls the embryologic development of the Müllerian system, including the fallopian tubes. Recent studies have shown that fallopian tube secretory epithelial cells (FTSECs) give rise to the most common form of ovarian cancer, high-grade serous ovarian carcinomas (HGSOCs)...
August 18, 2016: JCI Insight
https://www.readbyqxmd.com/read/27617248/uterine-clear-cell-carcinoma-of-postmenopausal-woman-a-case-report
#17
Soo-Ho Chung, Jung-Woo Park
Endometrial cancer is the most common gynecologic malignancy in developed countries. Clear cell carcinoma typically occurs in the ovaries, and very rarely occurs in the endometrium; it accounts for less than 3% of all endometrial cancers. It is presumed that clear cell carcinomas are of Müllerian duct origin, and an association with exposure to diethylstilbestrol (DES) or other nonsteroidal follicle stimulating hormones has been described. We report a case of a postmenopausal woman who presented with vaginal bleeding without a specific medical history...
August 2016: Journal of Menopausal Medicine
https://www.readbyqxmd.com/read/27595922/contribution-of-caudal-m%C3%A3-llerian-duct-mesenchyme-to-prostate-development
#18
Hannah Brechka, Erin M McAuley, Sophia M Lamperis, Gladell P Paner, Donald J Vander Griend
A fundamental understanding of prostate development and tissue homeostasis has the high potential to reveal mechanisms for prostate disease initiation and identify novel therapeutic approaches for disease prevention and treatment. Our current understanding of prostate lineage specification stems from the use of developmental model systems that rely upon the embryonic preprostatic urogenital sinus mesenchyme to induce the formation of mature prostate epithelial cells. It is unclear, however, how the urogenital sinus epithelium can derive both adult urethral glands and prostate epithelia...
November 15, 2016: Stem Cells and Development
https://www.readbyqxmd.com/read/27587625/ovarian-cancer-version-1-2016-nccn-clinical-practice-guidelines-in-oncology
#19
Robert J Morgan, Deborah K Armstrong, Ronald D Alvarez, Jamie N Bakkum-Gamez, Kian Behbakht, Lee-May Chen, Larry Copeland, Marta Ann Crispens, Maria DeRosa, Oliver Dorigo, David M Gershenson, Heidi J Gray, Ardeshir Hakam, Laura J Havrilesky, Carolyn Johnston, Shashikant Lele, Lainie Martin, Ursula A Matulonis, David M O'Malley, Richard T Penson, Sanja Percac-Lima, Mario Pineda, Steven C Plaxe, Matthew A Powell, Elena Ratner, Steven W Remmenga, Peter G Rose, Paul Sabbatini, Joseph T Santoso, Theresa L Werner, Jennifer Burns, Miranda Hughes
This selection from the NCCN Guidelines for Ovarian Cancer focuses on the less common ovarian histopathologies (LCOHs), because new algorithms were added for LCOHs and current algorithms were revised for the 2016 update. The new LCOHs algorithms include clear cell carcinomas, mucinous carcinomas, and grade 1 (low-grade) serous carcinomas/endometrioid epithelial carcinomas. The LCOHs also include carcinosarcomas (malignant mixed Müllerian tumors of the ovary), borderline epithelial tumors (also known as low malignant potential tumors), malignant sex cord-stromal tumors, and malignant germ cell tumors...
September 2016: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/27538791/impact-of-oviductal-versus-ovarian-epithelial-cell-of-origin-on-ovarian-endometrioid-carcinoma-phenotype-in-the-mouse
#20
Rong Wu, Yali Zhai, Rork Kuick, Anthony N Karnezis, Paloma Garcia, Anum Naseem, Tom C Hu, Eric R Fearon, Kathleen R Cho
Endometrioid carcinoma (EC) is a relatively indolent ovarian carcinoma subtype that is nonetheless deadly if detected late. Existing genetically engineered mouse models (GEMMs) of the disease, based on transformation of the ovarian surface epithelium (OSE), take advantage of known ovarian EC driver gene lesions, but do not fully recapitulate the disease features seen in patients. An EC model in which the Apc and Pten tumour suppressor genes are conditionally deleted in murine OSE yields tumours that are biologically more aggressive and significantly less differentiated than human ECs...
November 2016: Journal of Pathology
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