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Gynecologic malignancies

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https://www.readbyqxmd.com/read/29670086/mir-98-5p-contributes-to-cisplatin-resistance-in-epithelial-ovarian-cancer-by-suppressing-mir-152-biogenesis-via-targeting-dicer1
#1
Yanan Wang, Wei Bao, Yuan Liu, Shiyu Wang, Shengjie Xu, Xi Li, Yanli Li, Sufang Wu
Epithelial ovarian cancer (EOC) is a highly lethal gynecological malignancy, and cisplatin resistance is usually correlated with the poor prognosis of EOC. Increasing evidence indicates that the dysregulation of miRNAs is related to chemotherapy sensitivity. In this study, we revealed that miR-98-5p, a member of the let-7 family, was enriched in cisplatin-resistant EOC cells compared with cisplatin-sensitive cells, and could promote cisplatin resistance in EOC cells. Further studies showed that miR-98-5p could directly target the 3'-UTR of Dicer1 and suppress its expression, causing global miRNA downregulation...
April 18, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29666703/sarcoid-like-mediastinal-lymphadenopathy-in-gynecologic-malignancy
#2
Bilal H Lashari, Megumi Asai, Gissele Randleman, Martha Sack, Rajeshkumar Patel
Noncaseating granulomas are seen surrounding tumors with varying frequency, possibly as part of an immune response to tumor cells. However, data about the association of sarcoid with gynecologic malignancy is sparse. We performed a search of our institutional database for all EBUS-TBNA biopsies conducted within the past five years that revealed granulomatous inflammation. All adult female patients with a history of gynecologic malignancy were included. Patients with a history of sarcoidosis or fungal or mycobacterial infection were excluded...
2018: Pulmonary Medicine
https://www.readbyqxmd.com/read/29665555/hesperidin-promotes-programmed-cell-death-by-downregulation-of-nongenomic-estrogen-receptor-signalling-pathway-in-endometrial-cancer-cells
#3
Z B Cincin, B Kiran, Y Baran, B Cakmakoglu
Endometrial carcinoma (EC) is the most common malignant gynecologic tumor in women. EC is thought to be caused by increasing estrogen levels relative to progesterone in the body. Hesperidin (Hsd), a biologically active flavonoid, could be extracted from Citrus species. It has been recently shown that Hsd could exert anticarcinogenic properties in different cancer types. However, the effects of Hsd and its molecular mechanisms on EC remain unclear. In this study, the antiproliferative, apoptotic and genomic effects of Hsd in EC and its underlying mechanisms were identified...
April 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29664848/morbidity-and-mortality-risk-assessment-in-gynecologic-oncology-surgery-using-the-american-college-of-surgeons-national-surgical-quality-improvement-program-database
#4
Adrian Kohut, Theofano Orfanelli, Juan Lucas Poggio, Darlene Gibbon, Alexandre Buckley De Meritens, Scott Richard
INTRODUCTION: Gynecologic oncology patients represent a distinct patient population with a variety of surgical risks. The American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) database provides an opportunity to analyze large cohorts of patients over extended periods with high accuracy. Our goal was to develop a postoperative risk assessment calculator capable of providing a standardized, objective means of preoperatively identifying high-risk patients in the gynecologic oncology population...
April 16, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29662648/visceral-abdominal-fat-measured-by-computer-tomography-as-a-prognostic-factor-for-gynecological-malignancies
#5
Johanna Nattenmüller, Joachim Rom, Tom Buckner, Jalal Arvin, Benedikt Bau, Christof Sohn, Hans-Ulrich Kauczor, Sarah Schott
Introduction: Obesity is associated with increased incidence of ovarian (OC), cervical (CC) and endometrium cancer (EC). However, the impact of body composition (BC) on overall survival (OS), especially of visceral adipose tissue (VAT) is not yet understood. Methods: In 189 women with gynecological malignancies (31 OC, 104 CC, 54 EC, mean age 62.9y; mean BMI 26.8 kg/m2 ; median follow-up 30.7months) with routine staging CT-scans at baseline (mean interval: 4.3 months), densitometric quantification of total (TAT), visceral, and subcutaneous-fat-area (SAT), inter-muscular-fat-area (IMFA), and skeletal-muscle-index (SMI) was performed to analyze the impact of BC on survival...
March 27, 2018: Oncotarget
https://www.readbyqxmd.com/read/29661495/narcotics-reduction-quality-and-safety-in-gynecologic-oncology-surgery-in-the-first-year-of-enhanced-recovery-after-surgery-protocol-implementation
#6
Jennifer E Bergstrom, Marla E Scott, Yewande Alimi, Ting-Tai Yen, Deborah Hobson, Karime K Machado, Edward J Tanner, Amanda N Fader, Sarah M Temkin, Stephanie Wethington, Kimberly Levinson, Sam Sokolinsky, Brandyn Lau, Rebecca L Stone
OBJECTIVES: Enhanced Recovery After Surgery (ERAS) programs are mechanisms for achieving value-based improvements in surgery. This report provides a detailed analysis of the impact of an ERAS program on patient outcomes as well as quality and safety measures during implementation on a gynecologic oncology service at a major academic medical center. METHODS: A retrospective review of gynecologic oncology patients undergoing elective laparotomy during the implementation phase of an ERAS program (January 2016 through December 2016) was performed...
April 13, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29661159/active-dna-end-processing-in-micronuclei-of-ovarian-cancer-cells
#7
Zizhi Tang, Juan Yang, Xin Wang, Ming Zeng, Jing Wang, Ao Wang, Mingcai Zhao, Liandi Guo, Cong Liu, Dehua Li, Jie Chen
BACKGROUND: Ovarian cancer is one of the most deadly gynecological malignancies and inclined to recurrence and drug resistance. Previous studies showed that the tumorigenesis of ovarian cancers and their major histotypes are associated with genomic instability caused by defined sets of pathogenic mutations. In contrast, the mechanism that influences the development of drug resistance and disease recurrence is not well elucidated. Solid tumors are prone to chromosomal instability (CIN) and micronuclei formation (MN)...
April 16, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29649025/risk-of-anal-cancer-in-women-with-a-human-papillomavirus-related-gynecological-neoplasm-puerto-rico-1987-2013
#8
Adrianna I Acevedo-Fontánez, Erick Suárez, Carlos R Torres Cintrón, Ana P Ortiz
OBJECTIVE: The aim of the study was to estimate the magnitude of the association between HPV-related gynecological neoplasms and secondary anal cancer among women in Puerto Rico (PR). MATERIALS AND METHODS: We identified 9,489 women who had been diagnosed with a primary cervical, vaginal, or vulvar tumor during 1987-2013. To describe the trends of invasive cervical, vulvar, vaginal, and anal cancer, the age-adjusted incidence rates were estimated using the direct method (2000 US as Standard Population)...
April 11, 2018: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/29643656/comparison-of-conventional-smear-and-liquid-based-cytology-preparation-in-diagnosis-of-lung-cancer-by-bronchial-wash-and-transbronchial-needle-aspiration
#9
Aasma Nalwa, Ritika Walia, Varsha Singh, Karan Madan, Sandeep Mathur, Venkateshwaran Iyer, Deepali Jain
Introduction: Liquid-based cytology (LBC), initially developed for screening gynecologic specimens, is now being used in nongynecologic aspiration and exfoliative specimens. In this study, the diagnostic yield and utility of thin-prep (TP) was compared with conventional preparations to ascertain its utility in improving the diagnosis of respiratory lesions. Materials and Methods: Bronchial washings (BW) and transbronchial needle aspirates (TBNA) (bronchoscopy/endobronchial ultrasound-guided) from 70 consecutive patients of mediastinal masses and endo/peribronchial growths were included...
April 2018: Journal of Cytology
https://www.readbyqxmd.com/read/29643276/expression-of-placenta-growth-factor-is-associated-with-unfavorable-prognosis-of-advanced-stage-serous-ovarian-cancer
#10
Qin Meng, Pengjing Duan, Lin Li, Yongmei Miao
Ovarian cancer is the fourth leading cause of cancer death in women and the most fatal gynecologic malignancy. Placenta growth factor (PGF), a member of the vascular endothelial growth factor, plays an important role in angiogenesis. The overexpression of PGF was observed in several types of cancers, but the clinical significance of PGF in epithelial ovarian cancer (EOC) is still unknown. To explore the prognostic value of PGF among patients with serous EOC, we analyzed the expression of PGF in 89 EOC specimens by immunohistochemistry...
April 2018: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29642758/identification-of-significant-gene-signatures-and-prognostic-biomarkers-for-patients-with-cervical-cancer-by-integrated-bioinformatic-methods
#11
Xiaofang Li, Run Tian, Hugh Gao, Feng Yan, Le Ying, Yongkang Yang, Pei Yang, Yan'e Gao
Cervical cancer is the leading cause of death with gynecological malignancies. We aimed to explore the molecular mechanism of carcinogenesis and biomarkers for cervical cancer by integrated bioinformatic analysis. We employed RNA-sequencing details of 254 cervical squamous cell carcinomas and 3 normal samples from The Cancer Genome Atlas. To explore the distinct pathways, messenger RNA expression was submitted to a Gene Set Enrichment Analysis. Kyoto Encyclopedia of Genes and Genomes and protein-protein interaction network analysis of differentially expressed genes were performed...
January 1, 2018: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/29628985/clinical-characteristics-and-prognosis-associated-with-multiple-primary-cancers-in-breast-cancer-patients
#12
Bong Kyun Kim, Se Jeong Oh, Jeong-Yoon Song, Han-Byoel Lee, Min Ho Park, Yongsik Jung, Woo-Chan Park, Jina Lee, Woo Young Sun
Purpose: Breast cancer is one of the most common malignancies worldwide and the second most common cancer among Korean women. The prognosis of breast cancer is poor in patients with other primary cancers. However, there have been few clinical studies regarding this issue. Therefore, we analyzed the characteristics and prognosis of patients with breast cancer with multiple primary cancers (MPCs). Methods: Data from the Korean Breast Cancer Society Registry were analyzed...
March 2018: Journal of Breast Cancer
https://www.readbyqxmd.com/read/29628794/surface-markers-of-cancer-stem-like-cells-of-ovarian-cancer-and-their-clinical-relevance
#13
REVIEW
Aleksandra Klemba, J Karolina Purzycka-Olewiecka, Gabriel Wcisło, Anna M Czarnecka, Sławomir Lewicki, Bogdan Lesyng, Cezary Szczylik, Claudine Kieda
Cancer stem-like cells (CSLCs) are defined as cancer cells with stem cell characteristics. Although CSLCs constitute no more than a few percent of the tumor mass, they play important roles in cancer chemo-resistance, metastasis and disease recurrence. Ovarian cancer (OC) is considered the most aggressive gynecological malignancy in which the role of CSLCs is of major significance, although it remains to be specified. The studies describing ovarian CSLC phenotype vary in the definition of the molecular pattern of expression of the main markers such as CD133, CD44, CD117, and CD24...
March 2018: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/29628613/locoregional-therapies-for-the-treatment-of-hepatic-metastases-from-breast-and-gynecologic-cancers
#14
REVIEW
Samdeep K Mouli, Ramona Gupta, Neil Sheth, Andrew C Gordon, Robert J Lewandowski
Breast cancer is the most common women's malignancy in the United States and is the second leading cause of cancer death. More than half of patients with breast cancer will develop hepatic metastases; this portends a poorer prognosis. In the appropriately selected patient, there does appear to be a role for curative (surgery, ablation) or palliative (intra-arterial treatments) locoregional therapy. Gynecologic malignancies are less common and metastases to the liver are most often seen in the setting of disseminated disease...
March 2018: Seminars in Interventional Radiology
https://www.readbyqxmd.com/read/29627688/chemosensitizing-effects-of-metformin-on-cisplatin-and-paclitaxel-resistant-ovarian-cancer-cell-lines
#15
Isabella Dos Santos Guimarães, Taciane Ladislau-Magescky, Nayara Gusmão Tessarollo, Diandra Zipinotti Dos Santos, Etel Rodrigues Pereira Gimba, Cinthya Sternberg, Ian Victor Silva, Leticia Batista Azevedo Rangel
BACKGROUND: Epithelial ovarian cancer (EOC) remains the most lethal gynecologic malignancy. Primary cytoreductive surgery with adjuvant taxane-platinum chemotherapy is the standard treatment to fight ovarian cancer, however, their side effects are severe, and chemoresistance emerges at high rates. Therefore, EOC clinic urges for novel treatment strategies to reverse chemoresistance and to improve the survival rates. Metformin has been shown to act in synergy with certain anti-cancer agents, overcoming chemoresistance in various types of tumors...
November 21, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29625422/paclitaxel-and-di-fluorinated-curcumin-loaded-in-albumin-nanoparticles-for-targeted-synergistic-combination-therapy-of-ovarian-and-cervical-cancers
#16
Kaustubh A Gawde, Samaresh Sau, Katyayani Tatiparti, Sushil K Kashaw, Mohammad Mehrmohammadi, Asfar S Azmi, Arun K Iyer
Paclitaxel (PTX) encapsulated in albumin (Abraxane® ) is an FDA approved frontline nano-formulation for treating advance metastatic pancreatic, lung and breast cancers. Currently in clinic, Abraxane® is being used as a one of the components of combination therapy regimens. On the other hand, difluorinated curcumin (CDF) is a novel and potent synthetic curcumin analogue that is being evaluated for several malignancies including pancreatic, liver, ovarian and breast cancers. To improve the bioavailability and targeting ability of hydrophobic PTX and CDF, we have encapsulated them in folic acid decorated bovine serum albumin nanoparticles, namely FA-BSA-PTX and FA-BSA-CDF, respectively...
March 28, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29621762/mifepristone-inhibits-the-migration-of-cervical-cancer-cells-by-inhibiting-exocrine-secretion
#17
Lin Sang, Xiaoyan Wang, Xingbo Zhao
Cervical cancer (CC) is one of the most common gynecological malignancies, and metastasis limits the use of surgical resection. Metapristone (MIF) was reported to suppress the proliferation and migration of several cancer cells. Exosomes play a variety of roles in cellular biological processes. The relation of exosomes and CC is less studied. Cell viability, apoptosis assay and migration assay was conducted in HeLa cells treated by MIF by CCK-8 kit, staining by Annexin V-fluorescein isothiocyanate and propidium iodide, and wound test respectively...
April 5, 2018: Pharmacology
https://www.readbyqxmd.com/read/29621396/reversal-of-ovarian-cancer-multidrug-resistance-by-a-combination-of-lah4-l1-simdr1-nanocomplexes-with-chemotherapeutics
#18
Nana Guo, Chen Gao, Jing Liu, Jun Li, Nan Liu, Yanli Hao, Lei Chen, Xiaoning Zhang
The mortality of ovarian cancer stably ranks first in gynecological malignancies due to the lack of specific symptoms and diagnostic methods at an early stage. For most patients, the cancer cells had metastasized before they were diagnosed. As a result 90% of them died of multidrug resistance to chemotherapeutics. In our study, RNAi technology was introduced and applied to overcome this big problem. LAH4-L1, an amphipathic cationic polypeptide, was reported to have high transfection efficiency and was firstly selected by us to deliver siMDR1 for overcoming ovarian cancer cells MDR...
April 5, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29621040/concomitant-repair-of-pelvic-floor-disorders-in-women-undergoing-surgery-for-gynecologic-malignancies
#19
Katarzyna Bochenska, Margaret Mueller, Julia Geynisman-Tan, Alix Leader-Cramer, Bhumy Davé, Christina Lewicky-Gaupp, Kimberly Kenton
OBJECTIVE: The aims of this study were to determine the rate and describe 30-day postoperative complications of concomitant pelvic organ prolapse and/or urinary incontinence (POPUI) procedures in women undergoing surgery for a gynecologic malignancy. METHODS: Women who underwent surgical intervention for a gynecologic malignancy between 2010 and 2014 were identified using postoperative International Classification of Diseases, Ninth Revision codes 179.0 to 184.9 in the American College of Surgeons National Surgical Quality Improvement Program database...
April 4, 2018: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/29620584/endometrial-carcinoma-with-an-unusual-morphology-in-a-patient-with-cornelia-de-lange-syndrome-a-case-study
#20
Keisei Tate, Hiroshi Yoshida, Mitsuya Ishikawa, Hanako Shimizu, Takashi Uehara, Tomoyasu Kato
Cornelia de Lange syndrome (CdLS) is a cohesinopathy, which is characterized by multiple structural anomalies as well as mental and growth retardation. A 36-yr-old nulliparous woman with oligomenorrhea was referred to us due to a mass in the uterine corpus. She had been clinically diagnosed with CdLS during infancy based on her specific facial features as well as growth and intellectual retardation. Imaging examinations and an endometrial biopsy revealed endometrial endometrioid carcinoma and polycystic ovary syndrome (PCOS)...
April 3, 2018: International Journal of Gynecological Pathology
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