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head and neck cancer care

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https://www.readbyqxmd.com/read/29790861/assessing-mr-linac-radiotherapy-robustness-for-anatomical-changes-in-head-and-neck-cancer
#1
Robert W Chuter, Andrew Pollitt, Philip Whitehurst, Ranald I Mackay, Marcel van Herk, Alan McWilliam
The MR-Linac will provide excellent soft tissue contrast for on-treatment imaging. It is well known that the electron return effect (ERE) results in areas of increased and decreased dose at air/tissue boundaries, which can be compensated for in plan optimisation. However, anatomical changes may affect the quality of this compensation. In this paper we aim to quantify the interaction of anatomical changes with ERE in head and neck (H&N) cancer patients.
 
 Twenty patients treated with either 66 Gy or 60 Gy in 30 fractions were selected...
May 23, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29789760/high-dose-rate-brachytherapy-in-treatment-of-non-melanoma-skin-cancer-of-head-and-neck-region-preliminary-results-of-a-prospective-single-institution-study
#2
Bita Kalaghchi, Ebrahim Esmati, Reza Ghalehtaki, Marzieh Gomar, Ramin Jaberi, Soraya Gholami, Somayyeh Babaloui, Mansoureh Nabavi, Sarvazad Sotoudeh, Nezhat Khanjani, Ali Kazemian, Farnaz Amouzegar-Hashemi, Mahdi Aghili, Marzieh Lashkari
Purpose: Skin cancers are the most common human malignancy with increasing incidence. Currently, surgery is standard of care treatment for non-melanoma skin cancers. However, brachytherapy is a growing modality in the management of skin cancers. Therefore, we aimed to assess the outcome of patients with non-melanoma skin cancers treated by high-dose-rate (HDR) brachytherapy with surface mold technique. Material and methods: In this prospective study, we recruited patients with basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) of the skin who were candidates for definitive or adjuvant brachytherapy during 2013-2014...
April 2018: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/29789167/prevalence-of-malnutrition-and-impact-on-clinical-outcomes-in-cancer-services-a-comparison-of-two-time-points
#3
Kathryn M Marshall, Jenelle Loeliger, Linda Nolte, Amber Kelaart, Nicole K Kiss
BACKGROUND: The prevention and management of malnutrition is increasingly recognised as a significant element of cancer care. By identifying and comparing cancer malnutrition in two large cross-sectional cancer populations, this study aims to provide a greater understanding of clinical characteristics and trajectories relating to cancer malnutrition. METHODS: A multi-centre point prevalence study was conducted in Victoria, Australia at two time points (March 2012, May 2014)...
May 2, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29784752/head-and-neck-cancers-advantages-of-advanced-radiation-therapy-and-importance-of-supportive-care
#4
Sharon Spencer
For more than a decade, the incidence of head and neck cancers has been increasing in the United States. Worldwide, they are the ninth most common cancer. Today, newer advances in radiotherapy (RT), such as fractionation, 4-dimensional cone-beam CT, and intensity-modulated RT, have provided clinicians with the opportunity for improved patient outcomes. At the NCCN 23rd Annual Conference, Sharon Spencer, MD, described the advantages of advances in RT and the means to mitigate untoward side effects.
May 2018: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29783911/can-predictive-modeling-identify-head-and-neck-oncology-patients-at-risk-for-readmission
#5
Amy M Manning, Keith A Casper, Kay St Peter, Keith M Wilson, Jonathan R Mark, Ryan M Collar
Objective Unplanned readmission within 30 days is a contributor to health care costs in the United States. The use of predictive modeling during hospitalization to identify patients at risk for readmission offers a novel approach to quality improvement and cost reduction. Study Design Two-phase study including retrospective analysis of prospectively collected data followed by prospective longitudinal study. Setting Tertiary academic medical center. Subjects and Methods Prospectively collected data for patients undergoing surgical treatment for head and neck cancer from January 2013 to January 2015 were used to build predictive models for readmission within 30 days of discharge using logistic regression, classification and regression tree (CART) analysis, and random forests...
May 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29776851/treatment-planning-dose-accuracy-improvement-in-the-presence-of-dental-implants
#6
Holly M Parenica, John R Ford, Panayiotis Mavroidis, Ying Li, Nikos Papanikolaou, Sotirios Stathakis
Streaking artifacts in computed tomography (CT) scans caused by metallic dental implants (MDIs) can lead to inaccuracies in dose calculations. This study quantifies and compares the effect of MDIs on dose distributions using the collapsed cone convolution superposition (CCCS) and Monte Carlo (MC) algorithms, with and without correcting for the density of the MDIs. Ion chamber measurements were taken to test the ability of the algorithms in Pinnacle3 and Monaco to calculate dose near high-Z materials. Nine previously treated patients with head and neck cancer were included in this study...
May 15, 2018: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29764866/lrrc15-is-a-novel-mesenchymal-protein-and-stromal-target-for-antibody-drug-conjugates
#7
James W Purcell, Sonia G Tanlimco, Jonathan A Hickson, Melvin Fox, Mien Sho, Lisa Durkin, Tamar Uziel, Rick Powers, Kelly D Foster-Duke, Thomas McGonigal, Subashri Kumar, Josue Samayoa, Dong Zhang, Joann P Palma, Sasmita Mishra, Diane Hollenbaugh, Kurt Gish, Susan E Morgan-Lappe, Eric D Hsi, Debra T Chao
Progress in understanding tumor stromal biology has been constrained in part because cancer-associated fibroblasts (CAF) are a heterogeneous population with limited cell type-specific protein markers. Using RNA expression profiling, we identified the membrane protein leucine rich repeat containing 15 (LRRC15) as highly expressed in multiple solid tumor indications with limited normal tissue expression. LRRC15 was expressed on stromal fibroblasts in many solid tumors (e.g., breast, head and neck, lung, pancreatic) as well as directly on a subset of cancer cells of mesenchymal origin (e...
May 15, 2018: Cancer Research
https://www.readbyqxmd.com/read/29761228/patterns-of-care-analysis-for-head-neck-cancer-of-unknown-primary-site-a-survey-inside-the-german-society-of-radiation-oncology-degro
#8
Jens Müller von der Grün, Dimitra Bon, Claus Rödel, Panagiotis Balermpas
BACKGROUND: Due to the absence of randomized trials, the optimal management for squamous cell cancer of unknown primary in the head and neck region (SCCHN CUP) remains controversial. Current strategies are based on retrospective studies, clinical experience, and institutional policies. METHODS: An anonymous questionnaire with a total of 24 questions was created and distributed by the use of an online version (Google Forms®, Google, Mountain View, CA, USA) as well as a printout version as equivalent option...
May 14, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29756633/immunotherapy-in-head-and-neck-cancer-scientific-rationale-current-treatment-options-and-future-directions
#9
Uta Rothschild, Laurent Muller, Axel Lechner, Hans A Schlösser, Dirk Beutner, Heinz Läubli, Alfred Zippelius, Sacha I Rothschild
Head and neck squamous cell carcinoma (HNSCC) is a frequent tumour arising from multiple anatomical subsites in the head and neck region. The treatment for early-stage disease is generally single modality, either surgery or radiotherapy. The treatment for locally advanced tumours is multimodal. For recurrent/metastatic HNSCC palliative chemotherapy is standard of care. The prognosis is limited and novel treatment approaches are urgently needed. HNSCC evades immune responses through multiple resistance mechanisms...
May 14, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29756612/cancer-of-the-head-and-neck-a-set-of-indicators-based-on-register-and-administrative-data
#10
A Andreano, M Ansarin, D Alterio, R Bruschini, M G Valsecchi, A G Russo
Head and neck (H&N) tumours are a heterogeneous group of neoplasms with 5-year relative survival ranging from about 25% for the hypopharynx to 60% for the larynx in Europe. To improve survival rates, along with therapeutic improvements, it is important to standardise and optimise care received by patients with H&N tumours across different healthcare providers. To reach this goal, it is necessary to evaluate adherence to standards of received care at a population level. Published guidelines can serve as the basis to develop indicators, which can be computed from administrative health databases, measuring the adherence to specific recommendations at the individual level in unselected H&N cancer patients, identified from a population cancer register...
February 2018: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/29744681/proton-therapy-for-head-and-neck-cancer
#11
REVIEW
Joseph K Kim, Jonathan E Leeman, Nadeem Riaz, Sean McBride, Chiaojung Jillian Tsai, Nancy Y Lee
The application of proton beam radiation therapy in the treatment of head and neck cancer has grown tremendously in the past few years. Globally, widespread interest in proton beam therapy has led to multiple research efforts regarding its therapeutic value and cost-effectiveness. The current standard of care using modern photon radiation technology has demonstrated excellent treatment outcomes, yet there are some situations where disease control remains suboptimal with the potential for detrimental acute and chronic toxicities...
May 9, 2018: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/29742280/quantitative-survival-impact-of-composite-treatment-delays-in-head-and-neck-cancer
#12
Allen S Ho, Sungjin Kim, Mourad Tighiouart, Alain Mita, Kevin S Scher, Joel B Epstein, Anna Laury, Ravi Prasad, Nabilah Ali, Chrysanta Patio, Jon Mallen St-Clair, Zachary S Zumsteg
BACKGROUND: Multidisciplinary management of head and neck cancer (HNC) must reconcile increasingly sophisticated subspecialty care with timeliness of care. Prior studies examined the individual effects of delays in diagnosis-to-treatment interval, postoperative interval, and radiation interval but did not consider them collectively. The objective of the current study was to investigate the combined impact of these interwoven intervals on patients with HNC. METHODS: Patients with HNC who underwent curative-intent surgery with radiation were identified in the National Cancer Database between 2004 and 2013...
May 9, 2018: Cancer
https://www.readbyqxmd.com/read/29742271/use-of-trolamine-to-prevent-and-treat-acute-radiation-dermatitis-a-systematic-review-and-meta-analysis
#13
Amanda Gomes de Menêses, Paula Elaine Diniz Dos Reis, Eliete Neves Silva Guerra, Graziela De Luca Canto, Elaine Barros Ferreira
OBJECTIVE: to evaluate the effects of trolamine in the prevention or treatment of radiation dermatitis. METHOD: systematic review and meta-analysis. Detailed individual search strategies for Cinahl, Cochrane Library Central, LILACS, PubMed, and Web of Science were developed in January 2016. A manual search was also performed to find additional references. A grey literature search was executed by using Google Scholar. Two researchers independently read the titles and abstracts from every cross-reference...
2018: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/29736758/socioeconomic-status-and-quality-of-life-in-patients-with-locally-advanced-head-and-neck-cancer
#14
S Tribius, M S Meyer, C Pflug, H Hanken, C-J Busch, A Krüll, C Petersen, C Bergelt
PURPOSE: Socioeconomic aspects play an important role in health care. Patients with locally advanced head and neck cancer (LAHNC) experience detrimental effects on their quality of life (QoL). This prospective study examines QoL differences between patients with different socioeconomic status (SES) after intensity-modulated radiation therapy (IMRT). PATIENTS AND METHODS: In all, 161 patients were questioned at the end of IMRT and at 12 and 24 months follow-up using the questionnaires of the European Organization for Research and Treatment of Cancer (EORTC) QLQ-30 and QLQ-HN35...
May 7, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29736121/analgesic-and-opioid-use-in-pain-associated-with-head-and-neck-radiation-therapy
#15
Sandeep Muzumder, S Nirmala, H U Avinash, Mg John Sebastian, Prashanth Bhat Kainthaje
Aim: The aim of the study is to find the incidence of analgesic and opioid use in pain associated in HNC patient undergoing radiation therapy. Background: Radiation therapy with concurrent chemotherapy has become the standard of care in head and neck cancer. Acute toxicity like mucositis and dysphagia has increased with aggressive therapy. Pain is an invariable accompaniment of oropharyngeal mucositis, which leads to decreased quality of life and treatment break...
April 2018: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/29733308/therapy-testing-in-a-spheroid-based-3d-cell-culture-model-for-head-and-neck-squamous-cell-carcinoma
#16
Jan Hagemann, Christian Jacobi, Sabine Gstoettner, Christian Welz, Sabina Schwenk-Zieger, Roland Stauber, Sebastian Strieth, Julian Kuenzel, Philipp Baumeister, Sven Becker
Current treatment options for advanced and recurrent head and neck squamous cell carcinoma (HNSCC) enclose radiation and chemo-radiation approaches with or without surgery. While platinum-based chemotherapy regimens currently represent the gold standard in terms of efficacy and are given in the vast majority of cases, new chemotherapy regimens, namely immunotherapy are emerging. However, the response rates and therapy resistance mechanisms for either chemo regimen are hard to predict and remain insufficiently understood...
April 20, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29728842/patients-characteristics-informing-practice-improving-individualized-nursing-care-in-the-radiation-oncology-setting
#17
Pauline M Rose
PURPOSE: A large number of patients attend for radiotherapy daily. Primary nurses in the study settings aim to individualize care for their patients. The individual characteristics of patients may determine their perceptions of nursing care, and provide guidance in tailoring their care. This study aimed to assess patients' personal characteristics on their perceptions of individualized care (IC) provided by nurses during a course of radiotherapy, and to determine predictor variables that may inform nursing practice...
May 4, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29723766/timing-and-risk-of-mood-disorders-requiring-psychotropics-in-long-term-survivors-of-adult-cancers-a-nationwide-cohort-study
#18
Wen-Kuan Huang, Yeong-Yuh Juang, Chia-Chi Chung, Shu-Hao Chang, John Wen-Cheng Chang, Yung-Chang Lin, Hung-Ming Wang, Hsien-Kun Chang, Jen-Shi Chen, Chieh-Sheng Tsai, Kuang-Hui Yu, Chang-Fu Kuo, Lai-Chu See
BACKGROUND: The increasing number of long-term cancer survivors over the past few decades poses the challenge of mental health care needs. However, little is known about risks of mood disorders in long-term cancer survivors. METHODS: Long-term survivors (≥5 years) of adult cancers (LSAC) (n = 190,748) newly diagnosed between January 1, 2000 and December 31, 2007 were matched with one control. The primary outcome was diagnosis of mood disorders requiring psychotropics...
April 25, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29723399/outcomes-of-microvascular-flap-reconstruction-of-the-head-and-neck-in-patients-receiving-systemic-immunosuppressive-therapy-for-organ-transplantation
#19
Mark V Schaverien, Riley A Dean, Jeffrey N Myers, Lin Fang, Rene D Largo, Peirong Yu
BACKGROUND: For organ transplant recipients, cancer secondary to immunosuppressive therapy threatens long-term survival. The associated multiple comorbidities make major free flap reconstruction following cancer surgery a complicated event. This study evaluates the outcomes of free flap reconstruction in this population. METHODS: A retrospective chart review of all head and neck free flap cases in patients with a history of organ transplantation receiving systemic immunosuppressive therapy between 2005 and 2017 at a single-institution was conducted...
May 3, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29723320/the-effect-of-too-much-caring-a-preliminary-study
#20
Meriting Thokoane, C Peter Owen
PURPOSE: To determine the presence of burnout and psychiatric morbidity among prosthodontic residents and prosthodontists working in a maxillofacial prosthetic clinic and to compare these outcomes between those treating cancer patients and those not treating cancer patients. MATERIALS AND METHODS: Two questionnaires were used: the Maslach Burnout Inventory (MBI) and the General Health Questionnaire (GHQ-12). MBI assesses the three components of burnout (emotional exhaustion, depersonalization, and personal accomplishment), and the GHQ-12 screens for nonpsychotic psychiatric morbidity...
May 2018: International Journal of Prosthodontics
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