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head and neck cancer care

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https://www.readbyqxmd.com/read/27906454/immunotherapy-of-head-and-neck-cancer-emerging-clinical-trials-from-a-national-cancer-institute-head-and-neck-cancer-steering-committee-planning-meeting
#1
Julie E Bauman, Ezra Cohen, Robert L Ferris, David J Adelstein, David M Brizel, John A Ridge, Brian O'Sullivan, Barbara A Burtness, Lisa H Butterfield, William E Carson, Mary L Disis, Bernard A Fox, Thomas F Gajewski, Maura L Gillison, James W Hodge, Quynh-Thu Le, David Raben, Scott E Strome, Jean Lynn, Shakun Malik
Recent advances have permitted successful therapeutic targeting of the immune system in head and neck squamous cell carcinoma (HNSCC). These new immunotherapeutic targets and agents are being rapidly adopted by the oncologic community and hold considerable promise. The National Cancer Institute sponsored a Clinical Trials Planning Meeting to address the issue of how to further investigate the use of immunotherapy in patients with HNSCC. The goals of the meeting were to consider phase 2 or 3 trial designs primarily in 3 different patient populations: those with previously untreated, human papillomavirus-initiated oropharyngeal cancers; those with previously untreated, human papillomavirus-negative HNSCC; and those with recurrent/metastatic HNSCC...
December 1, 2016: Cancer
https://www.readbyqxmd.com/read/27893005/transforming-head-and-neck-surgeon-into-thyroid-expert-the-2016-hayes-martin-lecture
#2
Ashok R Shaha
With the rapid rise in the incidence of thyroid cancer, the number of thyroidectomies has increased remarkably in the last 10 years. Thyroidectomy accounts for approximately 40% of the workload in head and neck fellowship. The decision making in thyroid surgery is quite complex, especially when patients present with recurrent or advanced thyroid cancer. The complications of thyroid surgery can be very serious in relation to quality of life. Some of these complications can be avoided with meticulous surgical technique...
November 17, 2016: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/27891756/motility-patterns-in-mouse-colon-gastrointestinal-dysfunction-induced-by-anticancer-chemotherapy
#3
REVIEW
N J Spencer
Colon cancer is a leading cause of cancer-related death in humans. 5-Fluorouracil (5-FU), a major chemotherapy treatment, has been used for decades to fight numerous types of cancers, including breast, colon, and head and neck carcinomas. Unfortunately, a large proportion of patients treated with 5-FU develop toxicities that include diarrhea, mucositis, neutropenia, and vomiting. While the side effects of 5-FU are well known, the mechanisms underlying the induction of these unpleasant symptoms are poorly understood...
December 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/27882552/trends-and-the-utilization-of-transoral-robotic-surgery-with-neck-dissection-in-new-york-state
#4
Catherine H Frenkel, Jie Yang, Mengru Zhang, Elliot Regenbogen, Dana A Telem, Ghassan J Samara
OBJECTIVES: The timing of neck dissection (ND) in relation to transoral robotic surgery (TORS) is controversial. This study identifies local practice patterns and economic and social access disparities during adoption of TORS. STUDY DESIGN: We analyzed utilization patterns of TORS and ND using the New York Statewide Planning and Research Cooperative System all-payer administrative database. Statewide head and neck cancer incidence from the Centers for Disease Control and Prevention (Bethesda, MD) was used to control for overall cancer incidence...
November 24, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27880008/head-and-neck-surgical-subspecialty-training-in-africa-sustainable-models-to-improve-cancer-care-in-developing-countries
#5
Johannes J Fagan, Mark Zafereo, Joyce Aswani, James L Netterville, Wayne Koch
BACKGROUND: Cancer poses a health crisis in the developing world where surgery is the mainstay of treatment for head and neck cancers. However, a shortage of surgeons with appropriate skills exists. How do we train head and neck surgeons in developing countries and avoid a brain drain? The ideal model provides appropriate affordable training leading to establishment of head and neck cancer centers that teach and train others. METHODS: Different head and neck surgery training models are presented based on the personal experiences of the authors...
November 23, 2016: Head & Neck
https://www.readbyqxmd.com/read/27872523/impact-of-molecular-predictors-on-the-response-rates-in-head-and-neck-cancer-patients-an-observational-study
#6
Arvind Sathyamurthy, A S Kirthi Koushik, Mangala Gowri, M G Janaki, Nalini Kilara, T R Arul Ponni, Ram Charith Alva, S Mohan Kumar, Ram Abhinav Kannan, Ritika Harjani
Squamous cell carcinoma of head and neck region account for more than 25 % of male and more than 10 % of female cancers in India (1). Head and neck cancer treatment includes a multidisciplinary approach involving all specialties. Concurrent chemo-radiation is the standard of care in most of the subsites (2). Inspite of the multi-disciplinary approach, a plateau has been reached in terms of results with 5 year survival of locally advanced disease of around 30 % (3). In order to improve outcomes, there has been considerable interest in molecular profiling of head and neck cancers 4-10...
December 2016: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27869439/immunology-update-long-term-care-of-solid-organ-transplant-recipients
#7
S Paul Starr
Nearly 31,000 US patients received solid organ transplants in 2015 and the number is increasing. Care of transplant recipients includes management of a variety of common posttransplantation issues. Skin cancers are common because of immunosuppression and require skin examinations at intervals. Patients should be educated about the need to report new skin lesions. The rates of other cancers also are increased, including cancers of the head and neck, lung, esophagus, cervix, and urinary tract. Osteoporosis is common in transplant recipients; monitoring and early therapy are important...
November 2016: FP Essentials
https://www.readbyqxmd.com/read/27868440/-maximizing-nodal-yield-while-minimizing-surgical-morbidity-the-appropriate-neck-dissection
#8
István Háromi, Imre Gerlinger, László Lujber, Balázs Bendegúz Lőrincz
Cervical regional lymphadenectomy, also known as neck dissection, is a fundamental procedure in head and neck surgery. Its evolution over 110 years resulted in a great deal of confusion in the literature and in clinical practice, due to the heterogenicity in training, classification and surgical techniques, which makes outcomes comparability virtually impossible. The authors aim to clarify this situation in a structured manner, in order to facilitate communication among all specialists involved in multidisciplinary head and neck cancer care...
November 2016: Orvosi Hetilap
https://www.readbyqxmd.com/read/27865371/assessing-head-and-neck-cancer-patient-preferences-and-expectations-a-systematic-review
#9
REVIEW
Pierre Blanchard, Robert J Volk, Jolie Ringash, Susan K Peterson, Katherine A Hutcheson, Steven J Frank
INTRODUCTION: To enhance the value of care, interventions should aim at improving endpoints that matter to patients. The preferences of head and neck cancer patients regarding treatment outcomes are therefore a major topic for patient-centered research. METHODS: A systematic review (PROSPERO number CRD42016035692) was conducted by searching electronic databases (Medline, Embase, Cochrane, CINAHL) for articles evaluating patient or surrogate preferences in head and neck cancer...
November 2016: Oral Oncology
https://www.readbyqxmd.com/read/27861968/compliance-of-post-radiation-therapy-head-and-neck-cancer-patients-with-caries-preventive-protocols
#10
Agnieszka M Frydrych, Linda M Slack-Smith, Richard Parsons
BACKGROUND: Caries prevention is paramount in safeguarding the life quality of head and neck cancer patients and is dependent on patient compliance with caries preventive protocols. The purpose of this study was to examine this compliance. METHODS: All records of patients referred to one public oral medicine clinic servicing a head and neck oncology unit of one major Western Australian hospital, between January 2005 and December 2011 were examined. Data extracted included patient and cancer characteristics and compliance with dietary advice, dental care, oral hygiene instruction and fluoride use over a follow-up period of at least 12 months...
November 18, 2016: Australian Dental Journal
https://www.readbyqxmd.com/read/27860386/raman-spectroscopy-can-discriminate-between-normal-dysplastic-and-cancerous-oral-mucosa-a-tissue-engineering-approach
#11
Salman A Mian, Ceyla Yorucu, Muhammad Saad Ullah, Ihtesham U Rehman, Helen E Colley
Head and neck cancer (HNC) is the sixth most common malignancy worldwide. Squamous cell carcinoma, the primary cause of HNC, evolves from normal epithelium through dysplasia before invading the connective tissue to form a carcinoma. However, less than 18% of suspicious oral lesions progress to cancer, with diagnosis currently relying on histopathological evaluation, which is invasive and time consuming. A non-invasive, real-time, point-of-care method could overcome these problems and facilitate regular screening...
November 10, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27859893/psychosocial-effects-of-a-skin-camouflage-program-in-female-survivors-with-head-and-neck-cancer-a-randomized-controlled-trial
#12
Shu-Ching Chen, Bing-Shen Huang, Chien-Yu Lin, Kang-Hsing Fan, Joseph Tung-Chien Chang, Shu-Chen Wu, Yeur-Hur Lai
OBJECTIVE: The purpose of this study was to evaluate the effects of a skin camouflage program on disfigurement, self-esteem, social interaction, and body image in female head and neck cancer (HNC) survivors. METHODS: A prospective, repeated-measures, randomized controlled therapeutic intervention design was used. A total of 66 participants were randomly assigned to each group, with 32 in the experimental group and 34 in the control group. The experimental group received a 4-session skin camouflage program, and the control group received routine care...
November 15, 2016: Psycho-oncology
https://www.readbyqxmd.com/read/27859810/high-prevalence-of-self-reported-shoulder-complaints-after-thyroid-carcinoma-surgery
#13
Sean H P P Roerink, Lien Coolen, Maria E Schenning, Olga Husson, Jan W A Smit, Henri A Marres, Johannes H W de Wilt, Romana T Netea-Maier
BACKGROUND: Shoulder complaints are frequently reported after surgical treatment for thyroid carcinoma. However, no specific literature on this topic is available for these patients and, hence, its impact on quality of life (QOL) is unknown and there are no known predictors of shoulder complaints in this specific patient population. Therefore, the purpose of this study was to assess the prevalence of shoulder-related complaints and its relation to QOL and clinical characteristics after thyroid carcinoma surgery by means of a cross-sectional case control study in a tertiary referral center...
November 12, 2016: Head & Neck
https://www.readbyqxmd.com/read/27857249/palliative-care-considerations-for-patients-with-head-and-neck-cancer-with-children-at-home
#14
Verna L Hendricks-Ferguson, Rebecca Ott
Adult patients diagnosed with head and neck cancer (HNC) who may have contact with children in the home setting are at risk of experiencing distress because of embarrassing and challenging oral symptoms often associated with an HNC diagnosis and the side effects of required treatments. This article features a case study involving a patient diagnosed with HNC and details how oncology nurses can provide patients with HNC and their caregivers with resources and support.
December 1, 2016: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/27833872/effects-of-chemoradiation-on-hearing-in-patients-with-head-and-neck-malignancies-experience-at-a-tertiary-referral-care-hospital
#15
Abhineet Jain, Praveer K Banerjee, D Manjunath
Hearing loss as a side effect in patients with head and neck malignancies with chemoradiation is frequently ignored. Its effects on auditory functions are less studied and there are studies done on animals which are less reliable. The present study was undertaken to identify the type of hearing loss and also to quantify the degree of hearing loss in these patients. A prospective, descriptive study was undertaken in histologically proven head and neck cancer patients treated with cobalt 60 teletherapy who received a dose of 60-66 Grays (Gy) over a period of 6-7 weeks with concurrent Cisplatin 30 mg/m(2) once weekly for 6 weeks...
December 2016: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/27832247/living-in-a-patient-centric-universe
#16
Dennis H Kraus
Patients with head and neck cancer face a number of challenges in terms of treatment, cure of their underlying malignant condition, and quality of survivorship. This presentation will focus on the patient perception of both the quality of care and the empathy and availability of the head and neck oncology team. It has become evident that the quality of survivorship plays a central role in the patient's decision-making process. The process of decision making by the patient facing head and neck cancer and the impact on treatment choices will be explored...
November 10, 2016: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/27822049/prevalence-and-related-factors-of-psychological-distress-among-cancer-inpatients-using-routine-distress-thermometer-and-chinese-health-questionnaire-screening
#17
Yu-Jie Chiou, Nien-Mu Chiu, Liang-Jen Wang, Shau-Hsuan Li, Chun-Yi Lee, Ming-Kung Wu, Chien-Chih Chen, Yi-Shan Wu, Yu Lee
BACKGROUND: Clinical practice guidelines suggest routine screening for distress among cancer patients for immediate early psychiatric care. However, previous studies focusing on routine screening for psychological distress among cancer inpatients in Taiwan are scant. Thus, the aim of this study was to evaluate the prevalence and related factors of psychological distress and mental illness among cancer inpatients in Taiwan. PATIENTS AND METHODS: This study was conducted as a retrospective chart review in a general hospital in southern Taiwan...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27815711/the-rocky-treatment-course-identifying-a-high-risk-subgroup-of-head-and-neck-cancer-patients-for-supportive-interventions
#18
Horia Vulpe, Janet Ellis, Shao Hui Huang, Eshetu G Atenafu, Raymond W Jang, Gary Rodin, Jolie Ringash
PURPOSE: We aim to identify the risk factors for a "rocky" treatment course (RTC) in head and neck cancer. METHODS: A retrospective case-control study was conducted utilizing data from a prospective study. We defined the RTC as a composite of adverse outcomes including G-tube dependence and increased nursing interventions. Statistically associative variables were included in a multivariable logistic regression. We also evaluated whether the RTC, or its components, associated with worse cancer outcomes...
November 4, 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27804875/clostridium-difficile-infection-associations-with-chemotherapy-radiation-therapy-and-targeting-therapy-treatments
#19
Avi Peretz, Izhar Ben Shlomo, Orna Nitzan, Luigi Bonavina, Pmela M Schaffer, Moshe Schaffer
BACKGROUND: Although mucositis, diarrhea, and constipation as well as immunosuppression are well recognized side-effects of cancer treatment, the underlying mechanisms including changes in the composition of gut microbiota and Clostridium difficile infection have not yet been thoroughly reviewed. OBJECTIVE: We herein set out to review the literature regarding the relations between cancer chemotherapy, radiation treatment, and Clostridium difficile-associated colitis...
October 28, 2016: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/27803571/initial-experience-of-head-and-neck-cancer-patients-treated-in-an-oncologist-led-palliative-cancer-care-clinic-at-a-tertiary-cancer-care-center-in-uttar-pradesh-is-the-initiative-of-a-full-fledged-palliative-care-for-cancer-patients-justified
#20
Punita Lal, Mranalini Verma, Gaurav Kumar, Resham Shrivastava, Shaleen Kumar
INTRODUCTION: Poor socioeconomic status and illiteracy attribute to the advanced presentation of head and neck cancer (HNC) patients in India and are candidates for palliation in our setup. We set up a palliative cancer care clinic (PCCC), and an audit of initial 153 HNC patients is presented. AIMS AND OBJECTIVES: To assess the impact of palliative cancer care services. METHODOLOGY: Data of advanced HNC patients suited for palliation were collected to document demography, symptomatology, cancer treatment, and supportive care...
October 2016: Indian Journal of Palliative Care
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