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head and neck cancer care

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https://www.readbyqxmd.com/read/28077018/patient-factors-and-quality-of-life-outcomes-differ-among-four-subgroups-of-oncology-patients-based-on-symptom-occurrence
#1
Guro Lindviksmoen Astrup, Kristin Hofsø, Kristin Bjordal, Marianne Grønlie Guren, Ingvild Vistad, Bruce Cooper, Christine Miaskowski, Tone Rustøen
CONTEXT: Reviews of the literature on symptoms in oncology patients undergoing curative treatment, as well as patients receiving palliative care, suggest that they experience multiple, co-occurring symptoms and side effects. OBJECTIVES: The purposes of this study were to determine if subgroups of oncology patients could be identified based on symptom occurrence rates and if these subgroups differed on a number of demographic and clinical characteristics, as well as on quality of life (QoL) outcomes...
January 12, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28069153/working-in-silos-head-neck-cancer-patients-during-and-after-treatment-with-or-without-early-palliative-care-referral
#2
Helena Ullgren, Lily Kirkpatrick, Sini Kilpeläinen, Lena Sharp
PURPOSE: The primary aim was to describe patients with Head and Neck (H&N) cancer referred to palliative care and how the care transition from acute oncological to palliative care impacted on both Health related quality of life (HRQoL) and information. The secondary aim was to explore H&N cancer patients' HRQoL and perceived information. METHODS: H&N cancer patients were identified via the Swedish Cancer Register. Data were collected using the following questionnaires; European Organization for Research and Treatment of Cancer (EORTC) QLQ C-30, INFO25, and a study-specific questionnaire...
February 2017: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://www.readbyqxmd.com/read/28054529/a-retrospective-analysis-of-patients-with-head-and-neck-cancer-treated-with-radiation-hyperthermia-and-cetuximab-a-brief-report-of-outcome
#3
Nagraj G Huilgol
PURPOSE: Advanced head and neck cancer continues to have a dismal outcome. Chemoradiation remains the current standard of care. Chemoradiation has not achieved the desired increase in survival in locally advanced head and neck cancer. This is a retrospective analysis of six patients treated with hyperthermia, radiation therapy, and cetuximab. We wished to determine if this combination treatment would further improve the outcome. MATERIALS AND METHODS: Six patients with squamous cell cancer of the head and neck region were treated with hyperthermia, cetuximab, and radiation therapy...
July 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28048105/su-g-bra-17-tracking-multiple-targets-with-independent-motion-in-real-time-using-a-multi-leaf-collimator
#4
Y Ge, P Keall, P Poulsen
PURPOSE: Multiple targets with large intrafraction independent motion are often involved in advanced prostate, lung, abdominal, and head and neck cancer radiotherapy. Current standard of care treats these with the originally planned fields, jeopardizing the treatment outcomes. A real-time multi-leaf collimator (MLC) tracking method has been developed to address this problem for the first time. This study evaluates the geometric uncertainty of the multi-target tracking method. METHODS: Four treatment scenarios are simulated based on a prostate IMAT plan to treat a moving prostate target and static pelvic node target: 1) real-time multi-target MLC tracking; 2) real-time prostate-only MLC tracking; 3) correcting for prostate interfraction motion at setup only; and 4) no motion correction...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047807/su-d-brb-02-combining-a-commercial-autoplanning-engine-with-database-dose-predictions-to-further-improve-plan-quality
#5
S P Robertson, J A Moore, X Hui, T L DeWeese, P Tran, H Quon, Z Cheng, K Bzdusek, P Kumar, T R McNutt
PURPOSE: Database dose predictions and a commercial autoplanning engine both improve treatment plan quality in different but complimentary ways. The combination of these planning techniques is hypothesized to further improve plan quality. METHODS: Four treatment plans were generated for each of 10 head and neck (HN) and 10 prostate cancer patients, including Plan_A: traditional IMRT optimization using clinically relevant default objectives; Plan_B: traditional IMRT optimization using database dose predictions; Plan_C: autoplanning using default objectives; and Plan_D: autoplanning using database dose predictions...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28039504/end-of-life-care-for-head-and-neck-cancer-patients-a-population-based-study
#6
Tzu-Lung Kuo, Ching-Heng Lin, Rong-San Jiang, Ting-Ting Yen, Chen-Chi Wang, Kai-Li Liang
PURPOSE: Head and neck cancers (HNCs) usually present a poor prognosis and cause high morbidity rates. Recent surveys have demonstrated that HNC incidence rates are still on the increase in many countries. Our study objective was to assess the end-of-life care for patients with HNCs in Taiwan. METHODS: Data was retrieved from Taiwan's National Health Insurance Research Database, where we identified patients who had been diagnosed with HNCs from January 1997 to December 2010...
December 30, 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28034680/implementation-of-intensity-modulated-radiotherapy-for-head-and-neck-cancers-in-routine-practice
#7
C Bednarek, T V F Nguyen, M Puyraveau, É Bonnet, N Lescut, C Azélie, J Miny, O Mauvais, T Maurina, F Tochet, J-F Bosset, J Thariat, X S Sun
PURPOSE: To report on patterns of relapse following implementation of intensity-modulated radiotherapy and subsequent changes in practice in a tertiary care centre. PATIENTS AND METHODS: Between 2008 and 2011, 188 consecutive patients (mean age 59 years old) received intensity-modulated radiotherapies with curative intent for squamous cell carcinomas of the oral cavity (17.5%), oropharynx (43%), hypopharynx (21%), larynx (14%), sinonasal cavities (6%), nasopharynx (1...
December 26, 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28032680/cardiovascular-risk-and-prevention-in-patients-with-head-and-neck-cancer-treated-with-radiotherapy
#8
Christian C Okoye, Jessica Bucher, Curtis Tatsuoka, Sahil A Parikh, Guilherme H Oliveira, Michael K Gibson, Mitchell Machtay, Min Yao, Chad A Zender, Jennifer A Dorth
BACKGROUND: The underlying contributors to cardiovascular disease (CVD) in patients with head and neck squamous cell carcinoma (HNSCC) are poorly characterized. METHODS: Patients with HNSCC who underwent definitive or adjuvant (chemo)radiation between 2011 and 2013 were retrospectively reviewed. The 10-year risk estimates for a CVD event were calculated according to the Framingham Risk Score (FRS). RESULTS: One hundred fifteen patients with predominantly stage III/IV HNSCC had a median follow-up of 2 years...
December 29, 2016: Head & Neck
https://www.readbyqxmd.com/read/28028856/british-association-of-dermatologists-national-audit-on-nonmelanoma-skin-cancer-excision-2014
#9
D J Keith, D A R de Berker, A P Bray, S T Cheung, A Brain, M F Mohd Mustapa
BACKGROUND: Diagnosis and management of nonmelanoma skin cancer (NMSC) represents a large part of the dermatology workload, and complete excision is a required surgical standard for treatment. AIM: To conduct an audit of the surgical practice for the treatment of NMSC by dermatologists in the UK. METHODS: Data on 10 consecutive nonmicrographic excisions of nonmelanoma skin cancer by UK dermatologists. Data collected included site, preoperative diagnosis, histological diagnosis, proximity to previous scars, and histological deep and peripheral margins...
January 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28025390/prevalence-of-hpv-infection-in-racial-ethnic-subgroups-of-head-and-neck-cancer-patients
#10
Camille Ragin, Jeffrey C Liu, Gieira Jones, Olubunmi Shoyele, Bukola Sowunmi, Rachel Kennett, Harry J M Groen, Denise Gibbs, Elizabeth Blackman, Michael Esan, Margaret S Brandwein, Karthik Devarajan, Francesco Bussu, Rebecca Chernock, Chih-Yen Chien, Marc A Cohen, El-Mofty Samir, Suzuki Mikio, Gypsyamber D'Souza, Pauline Funchain, Charis Eng, Susanne M Gollin, Angela Hong, Yuh-S Jung, Maximilian Krüger, James Lewis, Patrizia Morbini, Santo Landolfo, Massimo Rittà, Jos Straetmans, Krisztina Szarka, Ruth Tachezy, Francis P Worden, Deborah Nelson, Samuel Gathere, Emanuela Taioli
The landscape of HPV infection in racial/ethnic subgroups of head and neck cancer (HNC) patients has not been evaluated carefully. In this study, a meta-analysis examined the prevalence of HPV in HNC patients of African ancestry. Additionally, a pooled analysis of subject-level data was also performed to investigate HPV prevalence and patterns of p16 (CDNK2A) expression amongst different racial groups. Eighteen publications (N = 798 Black HNC patients) were examined in the meta-analysis, and the pooled analysis included 29 datasets comprised of 3,129 HNC patients of diverse racial/ethnic background...
December 26, 2016: Carcinogenesis
https://www.readbyqxmd.com/read/28024718/patterns-of-dysphagia-and-acute-toxicities-in-patients-with-head-and-neck-cancer-undergoing-helical-imrt%C3%A2-concurrent-chemotherapy
#11
Laura B Moroney, Jennifer Helios, Elizabeth C Ward, Jane Crombie, Leesa F Wockner, Clare L Burns, Ann-Louise Spurgin, Claire Blake, Lizbeth Kenny, Brett G M Hughes
BACKGROUND: There is limited prospective data reporting the extent of treatment related toxicities associated with helical Intensity Modulated Radiotherapy (H-IMRT) for head and neck cancer (HNC). The study aim was to investigate severity, peak incidence and recovery patterns of dysphagia and related toxicities in patients undergoing H-IMRT±chemotherapy to examine when patients are experiencing symptoms requiring supportive clinical care. METHODS: Prospective study of 212 patients undergoing H-IMRT...
January 2017: Oral Oncology
https://www.readbyqxmd.com/read/28006087/significant-and-durable-clinical-benefit-from-trastuzumab-in-2-patients-with-her2-amplified-salivary-gland-cancer-and-a-review-of-the-literature
#12
Lauren M Thorpe, Alexa B Schrock, Rachel L Erlich, Vincent A Miller, James Knost, Nguyet Le-Lindqwister, Srinivas Jujjavarapu, Siraj M Ali, Jane J Liu
BACKGROUND: Salivary ductal carcinoma and carcinoma ex pleomorphic adenoma (CEPA) are aggressive salivary gland cancers with poor prognosis. The standard of care is resection with or without radiotherapy, and there are no established systemic therapy options. METHODS: We describe 1 patient with metastatic CEPA and 1 patient with metastatic recurrent salivary duct carcinoma whose tumors were evaluated by comprehensive genomic profiling. Testing identified human epidermal growth factor receptor 2 (HER2) amplification in both patients, and an additional activating HER2 mutation in the CEPA case...
December 22, 2016: Head & Neck
https://www.readbyqxmd.com/read/28004448/social-networks-social-support-and-social-negativity-a-qualitative-study-of-head-and-neck-cancer-caregivers-experiences
#13
M Balfe, K Keohane, K O'Brien, L Sharp
Head and neck cancer is a serious form of cancer that can generate substantial physical and psychosocial morbidity. Informal caregivers can help patients to manage head and neck cancer and its emotional impacts, both during and after treatment. Caregivers, however, can experience considerable stress as a result of their caring activities. Supportive relationships can protect caregivers from psychosocial strain. Thirty-one head and neck cancer caregivers were interviewed about their experiences of accessing social support from their social networks; difficulties that they experienced accessing this support; and strategies that they used to address these difficulties...
December 22, 2016: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28001302/impact-of-concomitant-chemoradiation-on-survival-for-patients-with-t1-2n1-head-and-neck-cancer
#14
Zachary S Zumsteg, Sungjin Kim, John M David, Emi J Yoshida, Mourad Tighiouart, Stephen L Shiao, Kevin Scher, Alain Mita, Eric J Sherman, Nancy Y Lee, Allen S Ho
BACKGROUND: Single-modality radiotherapy is considered a standard-of-care option for certain stage III, T1-2N1 head and neck squamous cell carcinomas (HNSCCs). The role of concomitant chemoradiation is not well established because there have been no studies comparing chemoradiation with radiation alone in this population. METHODS: This study analyzed patients in the National Cancer Data Base with cT1-2N1M0 invasive squamous cell carcinomas of the oropharynx, larynx, and hypopharynx who were diagnosed between 2004 and 2012 and were undergoing definitive radiation...
December 21, 2016: Cancer
https://www.readbyqxmd.com/read/27993569/a-genome-based-model-for-adjusting-radiotherapy-dose-gard-a-retrospective-cohort-based-study
#15
Jacob G Scott, Anders Berglund, Michael J Schell, Ivaylo Mihaylov, William J Fulp, Binglin Yue, Eric Welsh, Jimmy J Caudell, Kamran Ahmed, Tobin S Strom, Eric Mellon, Puja Venkat, Peter Johnstone, John Foekens, Jae Lee, Eduardo Moros, William S Dalton, Steven A Eschrich, Howard McLeod, Louis B Harrison, Javier F Torres-Roca
BACKGROUND: Despite its common use in cancer treatment, radiotherapy has not yet entered the era of precision medicine, and there have been no approaches to adjust dose based on biological differences between or within tumours. We aimed to assess whether a patient-specific molecular signature of radiation sensitivity could be used to identify the optimum radiotherapy dose. METHODS: We used the gene-expression-based radiation-sensitivity index and the linear quadratic model to derive the genomic-adjusted radiation dose (GARD)...
December 18, 2016: Lancet Oncology
https://www.readbyqxmd.com/read/27988865/photobiomodulation-therapy-management-of-mucosal-necrosis-of-the-oropharynx-in-previously-treated-head-and-neck-cancer-patients
#16
Joel B Epstein, Paul Y Song, Allen S Ho, Babak Larian, Arash Asher, Rene-Jean Bensadoun
Necrosis of the oral mucosa following head and neck cancer radiation therapy presents considerable clinical management challenges. We report three cases of symptomatic persisting oral ulcerations where the addition of photobiomodulation therapy resulted in a rapid resolution of the oral lesions and in patient symptoms. These cases suggest that photobiomodulation may represent an adjunct to care of these difficult to manage complications in oncology.
December 17, 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27987243/ahns-series-do-you-know-your-guidelines-principles-of-surgery-for-head-and-neck-cancer-a-review-of-the-national-comprehensive-cancer-network-guidelines
#17
Matthew C Miller, David Goldenberg
This article continues a series developed by the American Head and Neck Society's Education Committee entitled "Do you know your guidelines?" It is hoped that these features will increase awareness of and adherence to current best practices in head and neck cancer care. In this installment, the National Comprehensive Cancer Network (NCCN) guidelines for surgical therapy are reviewed. © 2016 Wiley Periodicals, Inc. Head Neck, 2016.
December 16, 2016: Head & Neck
https://www.readbyqxmd.com/read/27965858/development-and-feasibility-of-a-swallowing-intervention-package-sip-for-patients-receiving-radiotherapy-treatment-for-head-and-neck-cancer-the-sip-study-protocol
#18
Mary Wells, Emma King, Kate Toft, Fiona MacAulay, Joanne Patterson, Nadine Dougall, Nick Hulbert-Williams, Sally Boa, Eleanor Slaven, Julie Cowie, John McGarva, Patricia Gail Niblock, Julie Philp, Justin Roe
BACKGROUND: Head and neck cancer (HNC) is the sixth most common cancer worldwide, and the functional, psychological and social consequences of HNC cancer and its treatment can be severe and chronic. Dysphagia (swallowing problems) affects up to two thirds of patients undergoing combined chemoradiotherapy. Recent reviews suggest that prophylactic swallowing exercises may improve a range of short- and long-term outcomes; however, the importance of psychological and behavioural factors on adherence to swallowing exercises has not been adequately studied...
2016: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/27965842/a-head-and-neck-cancer-intervention-for-use-in-survivorship-clinics-a-protocol-for-a-feasibility-study
#19
Talya Salz, Mary S McCabe, Kevin C Oeffinger, Stacie Corcoran, Andrew J Vickers, Andrew L Salner, Ellen Dornelas, Rebecca Schnall, Nirupa J Raghunathan, Elizabeth Fortier, Shrujal S Baxi
BACKGROUND: Head and neck cancer survivors commonly experience severe long-term toxicities, late-occurring symptoms, and significant risks of the second primary malignancy and comorbid illnesses. With multiple simultaneous health issues, these complex cancer survivors often do not receive comprehensive health care that addresses their needs. A tool is needed to streamline and standardize comprehensive care for this cohort. METHODS/DESIGN: We designed the Head and Neck Survivorship Tool: Assessment and Recommendations (HN-STAR) to address health care challenges for head and neck cancer survivors...
2016: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/27965308/involvement-of-c-fos-in-the-promotion-of-cancer-stem-like-cell-properties-in-head-and-neck-squamous-cell-carcinoma
#20
Naoshad Muhammad, Sourav Bhattacharya, Robert Steele, Nancy J Phillips, Ratna B Ray
PURPOSE: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. Although improvements in surgical techniques, chemotherapy and radiation delivery, and supportive care have improved quality of life for patients with HNSCC, regional and distant recurrence remain common. Recent evidence suggests that cancer stem-like cells (CSCs) play a significant role in recurrence and chemo-resistant. We previously observed that c-Fos was highly up-regulated in the HNSCC sphere forming cells...
December 13, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
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