Nuruliarizki Shinta Pandupuspitasari, Faheem Ahmed Khan, Chunjie Huang, Azhar Ali, Muhammad Rizwan Yousaf, Farwa Shakeel, Ezi Masdia Putri, Windu Negara, Anis Muktiani, Bambang Waluyo Hadi Eko Prasetiyono, Limbang Kustiawan, Dimar Sari Wahyuni
In eukaryotes, the genome does not emerge in a specific shape but rather as a hierarchial bundle within the nucleus. This multifaceted genome organization consists of multiresolution cellular structures, such as chromosome territories, compartments, and topologically associating domains, which are frequently defined by architecture, design proteins including CTCF and cohesin, and chromatin loops. This review briefly discusses the advances in understanding the basic rules of control, chromatin folding, and functional areas in early embryogenesis...
June 29, 2023: Functional & Integrative Genomics