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vinay prasad

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https://www.readbyqxmd.com/read/27892992/overall-survival-in-cancer-drug-trials-as-a-new-surrogate-end-point-for-overall-survival-in-the-real-world
#1
Sham Mailankody, Vinay Prasad
No abstract text is available yet for this article.
November 17, 2016: JAMA Oncology
https://www.readbyqxmd.com/read/27882660/pediatric-dermatology-photoquiz-an-enlarging-facial-papule
#2
Daniel A Yanes, Vinay Prasad, Esteban Fernandez Faith
No abstract text is available yet for this article.
November 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27847626/correlation-of-biomarkers-thiobarbituric-acid-reactive-substance-nitric-oxide-and-central-subfield-and-cube-average-thickness-in-diabetic-retinopathy-a-cross-sectional-study
#3
Surabhi Ruia, Sandeep Saxena, S Prasad, Shashi R Sharma, Levent Akduman, Vinay K Khanna
BACKGROUND: To evaluate the role of thiobarbituric acid reactive substance (TBARS) and nitric oxide (NO) as biochemical biomarkers and central subfield (CST) and cube average thickness (CAT) as biomarkers for medical imaging in diabetic retinopathy. METHODS: Forty consecutive cases of diabetic retinopathy and 20 healthy controls were included. Cases were divided into two groups: non proliferative diabetic retinopathy (n = 20) and proliferative diabetic retinopathy (n = 20) according to ETDRS classification...
2016: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/27787285/heparin-induced-thrombocytopenia-a-tremendous-opportunity-for-randomization
#4
Austin Lammers, Thomas DeLoughery, Vinay Prasad
Heparin-induced thrombocytopenia and thrombosis (HITT) is both life-threatening with a complex immune-mediated process and clinically challenging to diagnose and treat. What further complicates matters is that thrombocytopenia is a frequently encountered laboratory value but rarely results in clinical signs of HITT. Decades into its initial description, we have anticoagulants with a small therapeutic index and associated high cost. The diagnosis is sometimes equivocal given our current laboratory diagnostics, and can take days to confirm...
October 25, 2016: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/27782770/new-experimental-models-of-the-blood-brain-barrier-for-cns-drug-discovery
#5
Mohammad A Kaisar, Ravi K Sajja, Shikha Prasad, Vinay V Abhyankar, Taylor Liles, Luca Cucullo
The blood-brain barrier (BBB) is a dynamic biological interface which actively controls the passage of substances between the blood and the central nervous system (CNS). From a biological and functional standpoint, the BBB plays a crucial role in maintaining brain homeostasis inasmuch that deterioration of BBB functions are prodromal to many CNS disorders. Conversely, the BBB hinders the delivery of drugs targeting the brain to treat a variety of neurological diseases. Area covered: This article reviews recent technological improvements and innovation in the field of BBB modeling including static and dynamic cell-based platforms, microfluidic systems and the use of stem cells and 3D printing technologies...
November 7, 2016: Expert Opinion on Drug Discovery
https://www.readbyqxmd.com/read/27760186/deciphering-transcriptional-programming-during-pod-and-seed-development-using-rna-seq-in-pigeonpea-cajanus-cajan
#6
Lekha T Pazhamala, Gaurav Agarwal, Prasad Bajaj, Vinay Kumar, Akanksha Kulshreshtha, Rachit K Saxena, Rajeev K Varshney
Seed development is an important event in plant life cycle that has interested humankind since ages, especially in crops of economic importance. Pigeonpea is an important grain legume of the semi-arid tropics, used mainly for its protein rich seeds. In order to understand the transcriptional programming during the pod and seed development, RNA-seq data was generated from embryo sac from the day of anthesis (0 DAA), seed and pod wall (5, 10, 20 and 30 DAA) of pigeonpea variety "Asha" (ICPL 87119) using Illumina HiSeq 2500...
2016: PloS One
https://www.readbyqxmd.com/read/27752015/gitelman-s-syndrome-presenting-with-hypocalcemic-tetany-and-hypokalemic-periodic-paralysis
#7
Kunal Gandhi, Dharmendra Prasad, Vinay Malhotra, Dhananjai Agrawal
Gitelman's syndrome is an autosomal recessive renal tubular disorder characterized by hypomagnesemia, hypokalemia, hypocalciuria, and metabolic alkalosis. Hypocalcemic tetany as a presentation of Gitelman's syndrome has rarely been reported in literature. We report a rare case of Gitelman's syndrome presenting with hypocalcemic tetany along with hypokalemic periodic paralysis. A 17-year-old female was admitted to our hospital with a history of perioral numbness and carpal spasms of five days duration with progressive quadriparesis developing over a period of few hours...
September 2016: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/27752010/a-clinicopathologic-study-of-glomerular-disease-a-single-center-five-year-retrospective-study-from-northwest-india
#8
Pankaj Beniwal, Lalit Pursnani, Sanjeev Sharma, R K Garsa, Mohit Mathur, Prasad Dharmendra, Vinay Malhotra, Dhanajai Agarwal
Studies published from centers across India have reported different and contradicting patterns of glomerular disease. In this retrospective study, we report our experience from a Tertiary Care Center in Northwest India. A total of 702 renal biopsies performed between 2008 and 2013 were reviewed of which 80 were excluded from the study because of having insufficient records or if the biopsies were taken from an allograft. The study included 411 males (66.1 %) and 211 females (33.9%) with an age range of 12-70 years (mean 30...
September 2016: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/27711927/the-rising-price-of-cancer-drugs-a-new-old-problem
#9
Vinay Prasad, Ruibin Wang, Salma H Afifi, Sham Mailankody
No abstract text is available yet for this article.
October 6, 2016: JAMA Oncology
https://www.readbyqxmd.com/read/27697586/precision-medicine-in-diffuse-large-b-cell-lymphoma-hype-or-hope
#10
Vinay Prasad
No abstract text is available yet for this article.
September 30, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27631115/taking-care-of-our-friends-and-neighbors-devita-s-the-death-of-cancer-and-the-challenge-of-letting-go
#11
Tomasz M Beer, Vinay Prasad
No abstract text is available yet for this article.
September 15, 2016: JAMA Oncology
https://www.readbyqxmd.com/read/27602743/perspective-the-precision-oncology-illusion
#12
Vinay Prasad
No abstract text is available yet for this article.
September 7, 2016: Nature
https://www.readbyqxmd.com/read/27594913/negative-trials-in-ovarian-cancer-is-there-such-a-thing-as-too-much-optimism
#13
EDITORIAL
Bishal Gyawali, Vinay Prasad
Recently, two clinical trials of novel agents in metastatic ovarian cancer were published: a phase 3 study of nintedanib and a phase 2 study of volasertib. There seemed to be discordance between the results and conclusions in the publication of both these trials. Despite not very optimistic results, the studies concluded optimistically in favor of the new agents under study. Using these examples, we point out the discrepancies and the risks of concluding optimistically based on statistical significance when the actual benefit is minimal...
2016: Ecancermedicalscience
https://www.readbyqxmd.com/read/27573659/same-data-different-interpretations
#14
Bishal Gyawali, Vinay Prasad
No abstract text is available yet for this article.
August 29, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27560393/effect-of-the-american-society-of-clinical-oncology-s-conflict-of-interest-policy-on-information-overload
#15
Aaron Boothby, Ruibin Wang, Jeremy Cetnar, Vinay Prasad
No abstract text is available yet for this article.
August 25, 2016: JAMA Oncology
https://www.readbyqxmd.com/read/27503924/rna-sequencing-identifies-transcriptionally-viable-gene-fusions-in-esophageal-adenocarcinomas
#16
Andrew E Blum, Srividya Venkitachalam, Yan Guo, Ann Marie Kieber-Emmons, Lakshmeswari Ravi, Apoorva K Chandar, Prasad G Iyer, Marcia I Canto, Jean S Wang, Nicholas J Shaheen, Jill S Barnholtz-Sloan, Sanford D Markowitz, Joseph E Willis, Yu Shyr, Amitabh Chak, Vinay Varadan, Kishore Guda
Esophageal adenocarcinoma is a deadly cancer with increasing incidence in the United States, but mechanisms underlying pathogenesis are still mostly elusive. In addressing this question, we assessed gene fusion landscapes by comprehensive RNA sequencing (RNAseq) of 55 pretreatment esophageal adenocarcinoma and 49 nonmalignant biopsy tissues from patients undergoing endoscopy for Barrett's esophagus. In this cohort, we identified 21 novel candidate esophageal adenocarcinoma-associated fusions occurring in 3...
October 1, 2016: Cancer Research
https://www.readbyqxmd.com/read/27497757/precision-medicine-in-acute-myeloid-leukemia-hope-hype-or-both
#17
Vinay Prasad, Robert Peter Gale
Precision medicine is interchangeably used with personalized medicine, genomic medicine and individualized medicine. Collectively, these terms refer to at least 5 distinct concepts in the context of AML. 1st, using molecular or omics data (e.g. genomics, epigenomics, transcriptomics, proteomics) to delineate or define subtypes of AML. 2nd, using these data to select the best therapy for someone with an AML subtype, such as a person with a FLT3-mutation. 3rd, using these data to monitor therapy-response such as measurable residual disease [MRD]-testing...
September 2016: Leukemia Research
https://www.readbyqxmd.com/read/27401893/thinking-systematically-about-the-off-label-use-of-cancer-drugs-and-combinations-for-patients-who-have-exhausted-proven-therapies
#18
Sham Mailankody, Vinay Prasad
No abstract text is available yet for this article.
September 2016: Oncologist
https://www.readbyqxmd.com/read/27381317/a-case-of-atypical-homicidal-cut-throat-injury
#19
Ajay Kumar S, Vinay Kumar Ms, Yp Raghavendra Babu, Mahadeshwara Prasad
Cut-throats can be of homicidal, suicidal or accidental origin. In cases of death from a cut-throat, distinguishing the cause is one of the important functions in crime investigation. The features that differentiate suicidal and homicidal cut-throat injuries are the presence of hesitation cuts, depth of wound, signs of struggle, edges of the wound, etc. In the case of a suicidal cut-throat, it is not uncommon to find hesitation cuts but in a homicidal cut-throat, it is uncommon. We present a case of a homicidal cut-throat injury but with hesitation cuts and tailing over the neck, unlike the classical description of homicidal cut-throat injury...
September 2016: Medico-legal Journal
https://www.readbyqxmd.com/read/27372859/is-prostate-cancer-screening-responsible-for-the-negative-results-of-prostate-cancer-treatment-trials
#20
Vinay Prasad
Clinical guidelines continue to move away from routine prostate specific antigen screening (PSA), once a widespread medical practice. A curious difference exists between early prostate cancer and early breast cancer. While randomized trials of therapy in early breast cancer continue to show overall survival benefit, this is not the case in prostate cancer, where prostatectomy was no better than observation in a recent trial, and where early androgen deprivation is no better than late androgen deprivation. Here, I make the case that prostate cancer screening contributes so greatly to over diagnosis that even treatment trials yield null results due to contamination with non-life threatening disease...
August 2016: Medical Hypotheses
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