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vinay prasad

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https://www.readbyqxmd.com/read/28430952/a-strategy-for-helicobacter-immunohistochemistry-utilization-in-pediatric-practice-%C3%A2-insights-from-morphologic-and-cost-benefit-analyses
#1
Miriam R Conces, Christina A Arnold, Peter B Baker, Christopher M Carter, Bonita Fung, Vinay Prasad, Michael A Arnold
Objectives: Recent studies in adults have examined the utility of immunohistochemistry (IHC) in detecting Helicobacter in gastric biopsy specimens and reached differing conclusions. Dedicated cost-benefit analysis of Helicobacter IHC in pediatric gastric biopsy specimens has not been performed. Methods: From 1,955 pediatric gastric biopsies in a 1-year period, we identified 63 Helicobacter -positive and 120 Helicobacter -negative biopsy specimens. All cases were scored according to the Updated Sydney System for the severity of inflammation...
November 1, 2016: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28395768/what-constitutes-an-unmet-medical-need-in-oncology-an-empirical-evaluation-of-author-usage-in-the-biomedical-literature
#2
Eric Lu, Joseph Shatzel, Florence Shin, Vinay Prasad
The phrase "unmet medical need" has important regulatory implications, but there is no empirical analysis of its real world usage. We sought to determine the annual US incidence, 5-year survival, and number of National Comprehensive Cancer Network (NCCN)-recommended regimens for indications described in the literature as an "unmet medical need." We queried Google Scholar to identify publications where authors used the phrase "unmet medical need" to refer to a specific cancer indication. For each indication, we investigated the annual US incidence, 5-year survival, and number of NCCN recommended regimens...
February 2017: Seminars in Oncology
https://www.readbyqxmd.com/read/28344145/how-the-uspstf-s-mammographic-screening-guidelines-should-be-interpreted
#3
EDITORIAL
Vinay Prasad
No abstract text is available yet for this article.
March 23, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28290490/the-high-price-of-anticancer-drugs-origins-implications-barriers-solutions
#4
REVIEW
Vinay Prasad, Kevin De Jesús, Sham Mailankody
Globally, annual spending on anticancer drugs is around US$100 billion, and is predicted to rise to $150 billion by 2020. In the USA, a novel anticancer drug routinely costs more than $100,000 per year of treatment. When adjusted for per capita spending power, however, drugs are most unaffordable in economically developing nations, such as India and China. Not only are launch prices high and rising, but individual drug prices are often escalated during exclusivity periods. High drug prices harm patients - often directly through increased out-of-pocket expenses, which reduce levels of patient compliance and lead to unfavourable outcomes - and harms society - by imposing cumulative price burdens that are unsustainable...
March 14, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28266519/drugs-that-lack-single-agent-activity-are-they-worth-pursuing-in-combination
#5
Bishal Gyawali, Vinay Prasad
No abstract text is available yet for this article.
April 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28169325/aza-heterocyclic-receptors-for-direct-electron-transfer-hemoglobin-biosensor
#6
Vinay Kumar, D M Nikhila Kashyap, Suraj Hebbar, R Swetha, Sujay Prasad, T Kamala, S S Srikanta, P R Krishnaswamy, Navakanta Bhat
Direct Electron Transfer biosensors, facilitating direct communication between the biomolecule of interest and electrode surface, are preferable compared to enzymatic and mediator based sensors. Although hemoglobin (Hb) contains four redox active iron centres, direct detection is not possible due to inaccessibility of iron centres and formation of dimers, blocking electron transfer. Through the coordination of iron with aza-heterocyclic receptors - pyridine and imidazole - we report a cost effective, highly sensitive and simple electrochemical Hb sensor using cyclic voltammetry and chronoamperometry...
February 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28114456/financial-conflicts-of-interest-among-hematologist-oncologists-on-twitter
#7
Derrick L Tao, Aaron Boothby, Joel McLouth, Vinay Prasad
No abstract text is available yet for this article.
March 1, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/27941917/oxidative-stress-and-carbon-metabolism-influence-aspergillus-flavus-transcriptome-composition-and-secondary-metabolite-production
#8
Jake C Fountain, Prasad Bajaj, Manish Pandey, Spurthi N Nayak, Liming Yang, Vinay Kumar, Ashwin S Jayale, Anu Chitikineni, Weijian Zhuang, Brian T Scully, R Dewey Lee, Robert C Kemerait, Rajeev K Varshney, Baozhu Guo
Contamination of crops with aflatoxin is a serious global threat to food safety. Aflatoxin production by Aspergillus flavus is exacerbated by drought stress in the field and by oxidative stress in vitro. We examined transcriptomes of three toxigenic and three atoxigenic isolates of A. flavus in aflatoxin conducive and non-conducive media with varying levels of H2O2 to investigate the relationship of secondary metabolite production, carbon source, and oxidative stress. We found that toxigenic and atoxigenic isolates employ distinct mechanisms to remediate oxidative damage, and that carbon source affected the isolates' expression profiles...
December 12, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27892992/overall-survival-in-cancer-drug-trials-as-a-new-surrogate-end-point-for-overall-survival-in-the-real-world
#9
Sham Mailankody, Vinay Prasad
No abstract text is available yet for this article.
November 17, 2016: JAMA Oncology
https://www.readbyqxmd.com/read/27882660/pediatric-dermatology-photoquiz-an-enlarging-facial-papule
#10
Daniel A Yanes, Vinay Prasad, Esteban Fernandez Faith
No abstract text is available yet for this article.
November 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27847626/correlation-of-biomarkers-thiobarbituric-acid-reactive-substance-nitric-oxide-and-central-subfield-and-cube-average-thickness-in-diabetic-retinopathy-a-cross-sectional-study
#11
Surabhi Ruia, Sandeep Saxena, S Prasad, Shashi R Sharma, Levent Akduman, Vinay K Khanna
BACKGROUND: To evaluate the role of thiobarbituric acid reactive substance (TBARS) and nitric oxide (NO) as biochemical biomarkers and central subfield (CST) and cube average thickness (CAT) as biomarkers for medical imaging in diabetic retinopathy. METHODS: Forty consecutive cases of diabetic retinopathy and 20 healthy controls were included. Cases were divided into two groups: non proliferative diabetic retinopathy (n = 20) and proliferative diabetic retinopathy (n = 20) according to ETDRS classification...
2016: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/27787285/heparin-induced-thrombocytopenia-a-tremendous-opportunity-for-randomization
#12
Austin Lammers, Thomas DeLoughery, Vinay Prasad
: Heparin-induced thrombocytopenia and thrombosis (HITT) is both life-threatening with a complex immune-mediated process and clinically challenging to diagnose and treat. What further complicates matters is that thrombocytopenia is a frequently encountered laboratory value but rarely results in clinical signs of HITT. Decades into its initial description, we have anticoagulants with a small therapeutic index and associated high cost. The diagnosis is sometimes equivocal given our current laboratory diagnostics, and can take days to confirm...
April 2017: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/27782770/new-experimental-models-of-the-blood-brain-barrier-for-cns-drug-discovery
#13
Mohammad A Kaisar, Ravi K Sajja, Shikha Prasad, Vinay V Abhyankar, Taylor Liles, Luca Cucullo
The blood-brain barrier (BBB) is a dynamic biological interface which actively controls the passage of substances between the blood and the central nervous system (CNS). From a biological and functional standpoint, the BBB plays a crucial role in maintaining brain homeostasis inasmuch that deterioration of BBB functions are prodromal to many CNS disorders. Conversely, the BBB hinders the delivery of drugs targeting the brain to treat a variety of neurological diseases. Area covered: This article reviews recent technological improvements and innovation in the field of BBB modeling including static and dynamic cell-based platforms, microfluidic systems and the use of stem cells and 3D printing technologies...
January 2017: Expert Opinion on Drug Discovery
https://www.readbyqxmd.com/read/27760186/deciphering-transcriptional-programming-during-pod-and-seed-development-using-rna-seq-in-pigeonpea-cajanus-cajan
#14
Lekha T Pazhamala, Gaurav Agarwal, Prasad Bajaj, Vinay Kumar, Akanksha Kulshreshtha, Rachit K Saxena, Rajeev K Varshney
Seed development is an important event in plant life cycle that has interested humankind since ages, especially in crops of economic importance. Pigeonpea is an important grain legume of the semi-arid tropics, used mainly for its protein rich seeds. In order to understand the transcriptional programming during the pod and seed development, RNA-seq data was generated from embryo sac from the day of anthesis (0 DAA), seed and pod wall (5, 10, 20 and 30 DAA) of pigeonpea variety "Asha" (ICPL 87119) using Illumina HiSeq 2500...
2016: PloS One
https://www.readbyqxmd.com/read/27752015/gitelman-s-syndrome-presenting-with-hypocalcemic-tetany-and-hypokalemic-periodic-paralysis
#15
Kunal Gandhi, Dharmendra Prasad, Vinay Malhotra, Dhananjai Agrawal
Gitelman's syndrome is an autosomal recessive renal tubular disorder characterized by hypomagnesemia, hypokalemia, hypocalciuria, and metabolic alkalosis. Hypocalcemic tetany as a presentation of Gitelman's syndrome has rarely been reported in literature. We report a rare case of Gitelman's syndrome presenting with hypocalcemic tetany along with hypokalemic periodic paralysis. A 17-year-old female was admitted to our hospital with a history of perioral numbness and carpal spasms of five days duration with progressive quadriparesis developing over a period of few hours...
September 2016: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/27752010/a-clinicopathologic-study-of-glomerular-disease-a-single-center-five-year-retrospective-study-from-northwest-india
#16
Pankaj Beniwal, Lalit Pursnani, Sanjeev Sharma, R K Garsa, Mohit Mathur, Prasad Dharmendra, Vinay Malhotra, Dhanajai Agarwal
Studies published from centers across India have reported different and contradicting patterns of glomerular disease. In this retrospective study, we report our experience from a Tertiary Care Center in Northwest India. A total of 702 renal biopsies performed between 2008 and 2013 were reviewed of which 80 were excluded from the study because of having insufficient records or if the biopsies were taken from an allograft. The study included 411 males (66.1 %) and 211 females (33.9%) with an age range of 12-70 years (mean 30...
September 2016: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/27711927/the-rising-price-of-cancer-drugs-a-new-old-problem
#17
Vinay Prasad, Ruibin Wang, Salma H Afifi, Sham Mailankody
No abstract text is available yet for this article.
October 6, 2016: JAMA Oncology
https://www.readbyqxmd.com/read/27697586/precision-medicine-in-diffuse-large-b-cell-lymphoma-hype-or-hope
#18
Vinay Prasad
No abstract text is available yet for this article.
September 30, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27631115/taking-care-of-our-friends-and-neighbors-devita-s-the-death-of-cancer-and-the-challenge-of-letting-go
#19
Tomasz M Beer, Vinay Prasad
No abstract text is available yet for this article.
January 1, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/27602743/perspective-the-precision-oncology-illusion
#20
Vinay Prasad
No abstract text is available yet for this article.
September 8, 2016: Nature
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