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https://www.readbyqxmd.com/read/28981174/reversal-of-warfarin-era-thinking
#1
Joseph J Shatzel, Molly M Daughety, Vinay Prasad, Thomas G DeLoughery
Anticoagulation offers benefits in appropriately selected patients, however, all anticoagulants increase the risk of bleeding, which can be, at times, life threatening. For decades, vitamin K antagonists were the only oral anticoagulants available to physicians and their patients. In recent years, we have witnessed the approval of five direct oral anticoagulants (DOACs), which have shifted prior paradigms in anticoagulation such as omitting the need for routine therapeutic monitoring and lessening concerns about food and drug interactions...
October 5, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28980180/non-inferiority-trials-in-medicine-practice-changing-or-a-self-fulfilling-prophecy
#2
EDITORIAL
Vinay Prasad
No abstract text is available yet for this article.
October 4, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/28978548/do-cancer-drugs-improve-survival-or-quality-of-life
#3
EDITORIAL
Vinay Prasad
No abstract text is available yet for this article.
October 4, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28975930/immunotherapy-tisagenlecleucel-the-first-approved-car-t-cell-therapy-implications-for-payers-and-policy-makers
#4
Vinay Prasad
No abstract text is available yet for this article.
October 4, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28956596/anticancer-activity-of-iridium-iii-complexes-based-on-a-pyrazole-appended-quinoline-based-bodipy
#5
Rajendra Prasad Paitandi, Sujay Mukhopadhyay, Roop Shikha Singh, Vinay Sharma, Shaikh M Mobin, Daya Shankar Pandey
A pyrazole-appended quinoline-based 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (L1, BODIPY) has been synthesized and used as a ligand for the preparation of iridium(III) complexes [Ir(phpy)2(L1)]PF6 (1; phpy = 2-phenylpyridine) and [(η(5)-C5Me5)Ir(L1)Cl]PF6 (2). The ligand L1 and complexes 1 and 2 have been meticulously characterized by elemental analyses and spectral studies (IR, electrospray ionization mass spectrometry, (1)H and (13)C NMR, UV/vis, fluorescence) and their structures explicitly authenticated by single-crystal X-ray analyses...
September 28, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28937074/clinicoepidemiological-profile-of-peritonitis-complicating-acute-peritoneal-dialysis-a-single-center-experience
#6
Kunal Gandhi, Dharmendra Prasad, Vinay Malhotra, Dhananjai Agrawal, Pankaj Beniwal, Amith Vijay Leon Dsouza
A prospective observational study examining the incidence and microbiological aspects of peritonitis complicating acute intermittent peritoneal dialysis (IPD) was performed. A total of 145 acute IPD treatments were included involving 112 patients. The majority of patients suffered from acute kidney injury (72.3%) secondary to sepsis. Peritonitis occurred in 31 treatment sessions, giving a frequency of 21.4% of procedures performed. The mean interval between starting dialysis and the first sign of peritonitis was 2...
September 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28923211/nivolumab-and-pembrolizumab-monoclonal-antibodies-against-programmed-cell-death-1-pd-1-that-are-interchangeable
#7
REVIEW
Vinay Prasad, Victoria Kaestner
Nivolumab (Opdivo, Bristol Meyer Squibb, New York, NY) and pembrolizumab (Keytruda, Merck, Kenilworth, NJ) are the first two US Food and Drug Administration (FDA)-approved monoclonal antibodies targeting programmed death-1 (PD-1). Nivolumab and pembrolizumab work by interfering with the interaction between PD-1 and programmed death ligand-1 (PD-L1), whose unimpeded interaction downregulates T cells allowing cancer cells to evade immune surveillance. These drugs have earned a series of FDA approvals for melanoma, non-small cell lung cancer (NSCLC), head and neck squamous cell cancer (HNSCC), urothelial cancer, classical Hodgkin lymphoma, and renal cell cancer...
April 2017: Seminars in Oncology
https://www.readbyqxmd.com/read/28892524/research-and-development-spending-to-bring-a-single-cancer-drug-to-market-and-revenues-after-approval
#8
Vinay Prasad, Sham Mailankody
Importance: A common justification for high cancer drug prices is the sizable research and development (R&D) outlay necessary to bring a drug to the US market. A recent estimate of R&D spending is $2.7 billion (2017 US dollars). However, this analysis lacks transparency and independent replication. Objective: To provide a contemporary estimate of R&D spending to develop cancer drugs. Design, Setting, and Participants: Analysis of US Securities and Exchange Commission filings for drug companies with no drugs on the US market that received approval by the US Food and Drug Administration for a cancer drug from January 1, 2006, through December 31, 2015...
September 11, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28829055/a-further-strategy-to-combat-the-high-price-of-anticancer-drugs
#9
Vinay Prasad, Kevin De Jesús, Sham Mailankody
No abstract text is available yet for this article.
October 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28817761/is-do-everything-always-appropriate-reply
#10
Tomasz M Beer, Vinay Prasad
No abstract text is available yet for this article.
August 17, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28750129/pemetrexed-in-nonsquamous-non-small-cell-lung-cancer-the-billion-dollar-subgroup-analysis
#11
Bishal Gyawali, Vinay Prasad
No abstract text is available yet for this article.
July 27, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28732060/formation-of-singlet-oxygen-by-decomposition-of-protein-hydroperoxide-in-photosystem-ii
#12
Vinay Pathak, Ankush Prasad, Pavel Pospíšil
Singlet oxygen (1O2) is formed by triplet-triplet energy transfer from triplet chlorophyll to O2 via Type II photosensitization reaction in photosystem II (PSII). Formation of triplet chlorophyll is associated with the change in spin state of the excited electron and recombination of triplet radical pair in the PSII antenna complex and reaction center, respectively. Here, we have provided evidence for the formation of 1O2 by decomposition of protein hydroperoxide in PSII membranes deprived of Mn4O5Ca complex...
2017: PloS One
https://www.readbyqxmd.com/read/28728605/surrogate-endpoints-in-oncology-when-are-they-acceptable-for-regulatory-and-clinical-decisions-and-are-they-currently-overused
#13
Robert Kemp, Vinay Prasad
BACKGROUND: Surrogate outcomes are not intrinsically beneficial to patients, but are designed to be easier and faster to measure than clinically meaningful outcomes. The use of surrogates as an endpoint in clinical trials and basis for regulatory approval is common, and frequently exceeds the guidance given by regulatory bodies. DISCUSSION: In this article, we demonstrate that the use of surrogates in oncology is widespread and increasing. At the same time, the strength of association between the surrogates used and clinically meaningful outcomes is often unknown or weak...
July 21, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28727973/pediatric-xanthogranulomatous-cystitis-the-first-described-case-in-a-pre-pubertal-male-and-review-of-the-literature
#14
Janae Preece, Vinay Prasad, Daryl McLeod
Xanthogranulomatous cystitis (XC) is a rare condition affecting the bladder thought to be caused by chronic inflammation. Fewer than 30 cases have been reported in the literature since being first described in 1932. We present the first reported case of XC in a pre-pubertal male and review the literature. A 10-year-old boy presenting with dysuria subsequently developed frequency. After failure of conservative management, an ultrasound of the bladder revealed a mass. The patient underwent partial cystectomy...
July 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/28719584/health-policy-me-too-drugs-with-limited-benefits-the-tale-of-regorafenib-for-hcc
#15
Bishal Gyawali, Vinay Prasad
No abstract text is available yet for this article.
November 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28715568/overestimating-the-benefit-of-cancer-drugs
#16
Vinay Prasad
No abstract text is available yet for this article.
July 13, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28672361/limitations-concerning-the-association-of-physician-sex-and-patient-outcomes
#17
Mark W Friedberg, Walid F Gellad, Vinay Prasad
No abstract text is available yet for this article.
July 1, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28662268/pembrolizumab-as-first-line-therapy-in-programmed-death-ligand-1-positive-advanced-lung-cancer-is-it-as-effective-as-we-think-it-is
#18
Daniel A Goldstein, Usama Bilal, Vinay Prasad
No abstract text is available yet for this article.
June 29, 2017: Cancer
https://www.readbyqxmd.com/read/28566059/the-effect-of-endograft-device-on-patient-outcomes-in-endovascular-repair-of-ruptured-abdominal-aortic-aneurysms
#19
Vinay Kansal, Sudhir Nagpal, Prasad Jetty
Objective Endovascular aneurysm repair for ruptured abdominal aortic aneurysm is being increasingly applied as the intervention of choice. The purpose of this study was to determine whether survival and reintervention rates after ruptured abdominal aortic aneurysm vary between endograft devices. Methods This cohort study identified all ruptured abdominal aortic aneurysms performed at The Ottawa Hospital from January 1999 to May 2015. Data collected included patient demographics, stability index at presentation, adherence to device instructions for use, endoleaks, reinterventions, and mortality...
January 1, 2017: Vascular
https://www.readbyqxmd.com/read/28550899/combined-effect-of-substance-p-and-curcumin-on-cutaneous-wound-healing-in-diabetic-rats
#20
Vinay Kant, Dinesh Kumar, Raju Prasad, Anu Gopal, Nitya N Pathak, Pawan Kumar, Surender K Tandan
BACKGROUND: Our earlier studies demonstrated that topically applied substance P (SP) or curcumin on excision skin wound accelerated the wound healing in streptozotocin-induced diabetic rats. In the present study, we aimed to evaluate the wound healing potential of combination of SP and curcumin in diabetic rats. MATERIALS AND METHODS: Open cutaneous excision wound was created on the back of each of the 60 diabetic rats. Wound-inflicted rats were equally divided into three groups namely, control, gel treated, and SP + curcumin treated...
May 15, 2017: Journal of Surgical Research
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