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https://www.readbyqxmd.com/read/28566059/the-effect-of-endograft-device-on-patient-outcomes-in-endovascular-repair-of-ruptured-abdominal-aortic-aneurysms
#1
Vinay Kansal, Sudhir Nagpal, Prasad Jetty
Objective Endovascular aneurysm repair for ruptured abdominal aortic aneurysm is being increasingly applied as the intervention of choice. The purpose of this study was to determine whether survival and reintervention rates after ruptured abdominal aortic aneurysm vary between endograft devices. Methods This cohort study identified all ruptured abdominal aortic aneurysms performed at The Ottawa Hospital from January 1999 to May 2015. Data collected included patient demographics, stability index at presentation, adherence to device instructions for use, endoleaks, reinterventions, and mortality...
January 1, 2017: Vascular
https://www.readbyqxmd.com/read/28550899/combined-effect-of-substance-p-and-curcumin-on-cutaneous-wound-healing-in-diabetic-rats
#2
Vinay Kant, Dinesh Kumar, Raju Prasad, Anu Gopal, Nitya N Pathak, Pawan Kumar, Surender K Tandan
BACKGROUND: Our earlier studies demonstrated that topically applied substance P (SP) or curcumin on excision skin wound accelerated the wound healing in streptozotocin-induced diabetic rats. In the present study, we aimed to evaluate the wound healing potential of combination of SP and curcumin in diabetic rats. MATERIALS AND METHODS: Open cutaneous excision wound was created on the back of each of the 60 diabetic rats. Wound-inflicted rats were equally divided into three groups namely, control, gel treated, and SP + curcumin treated...
May 15, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28543414/closed-financial-loops-when-they-happen-in-government-they-re-called-corruption-in-medicine-they-re-just-a-footnote
#3
Kevin De Jesus-Morales, Vinay Prasad
Many physicians are involved in relationships that create tension between a physician's duty to work in her patients' best interest at all times and her financial arrangement with a third party, most often a pharmaceutical manufacturer, whose primary goal is maximizing sales or profit. Despite the prevalence of this threat, in the United States and globally, the most common reaction to conflicts of interest in medicine is timid acceptance. There are few calls for conflicts of interest to be banned, and, to our knowledge, no one calls for conflicted practitioners to be reprimanded...
May 2017: Hastings Center Report
https://www.readbyqxmd.com/read/28534528/combining-drugs-and-extending-treatment-a-pfs-end-point-is-not-sufficient
#4
Bishal Gyawali, Vinay Prasad
No abstract text is available yet for this article.
May 23, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28520871/pharmaceutical-marketing-for-rare-diseases-regulating-drug-company-promotion-in-an-era-of-unprecedented-advertisement
#5
Sham Mailankody, Vinay Prasad
No abstract text is available yet for this article.
May 18, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28508688/extrarenal-wilms-tumor-with-skeletal-and-glial-differentiation
#6
Geok Chin Tan, Vinay Prasad
No abstract text is available yet for this article.
May 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28430952/a-strategy-for-helicobacter-immunohistochemistry-utilization-in-pediatric-practice-%C3%A2-insights-from-morphologic-and-cost-benefit-analyses
#7
Miriam R Conces, Christina A Arnold, Peter B Baker, Christopher M Carter, Bonita Fung, Vinay Prasad, Michael A Arnold
Objectives: Recent studies in adults have examined the utility of immunohistochemistry (IHC) in detecting Helicobacter in gastric biopsy specimens and reached differing conclusions. Dedicated cost-benefit analysis of Helicobacter IHC in pediatric gastric biopsy specimens has not been performed. Methods: From 1,955 pediatric gastric biopsies in a 1-year period, we identified 63 Helicobacter -positive and 120 Helicobacter -negative biopsy specimens. All cases were scored according to the Updated Sydney System for the severity of inflammation...
November 1, 2016: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28395768/what-constitutes-an-unmet-medical-need-in-oncology-an-empirical-evaluation-of-author-usage-in-the-biomedical-literature
#8
Eric Lu, Joseph Shatzel, Florence Shin, Vinay Prasad
The phrase "unmet medical need" has important regulatory implications, but there is no empirical analysis of its real world usage. We sought to determine the annual US incidence, 5-year survival, and number of National Comprehensive Cancer Network (NCCN)-recommended regimens for indications described in the literature as an "unmet medical need." We queried Google Scholar to identify publications where authors used the phrase "unmet medical need" to refer to a specific cancer indication. For each indication, we investigated the annual US incidence, 5-year survival, and number of NCCN recommended regimens...
February 2017: Seminars in Oncology
https://www.readbyqxmd.com/read/28344145/how-the-uspstf-s-mammographic-screening-guidelines-should-be-interpreted
#9
EDITORIAL
Vinay Prasad
No abstract text is available yet for this article.
March 24, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28290490/the-high-price-of-anticancer-drugs-origins-implications-barriers-solutions
#10
REVIEW
Vinay Prasad, Kevin De Jesús, Sham Mailankody
Globally, annual spending on anticancer drugs is around US$100 billion, and is predicted to rise to $150 billion by 2020. In the USA, a novel anticancer drug routinely costs more than $100,000 per year of treatment. When adjusted for per capita spending power, however, drugs are most unaffordable in economically developing nations, such as India and China. Not only are launch prices high and rising, but individual drug prices are often escalated during exclusivity periods. High drug prices harm patients - often directly through increased out-of-pocket expenses, which reduce levels of patient compliance and lead to unfavourable outcomes - and harms society - by imposing cumulative price burdens that are unsustainable...
June 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28266519/drugs-that-lack-single-agent-activity-are-they-worth-pursuing-in-combination
#11
Bishal Gyawali, Vinay Prasad
No abstract text is available yet for this article.
April 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28169325/aza-heterocyclic-receptors-for-direct-electron-transfer-hemoglobin-biosensor
#12
Vinay Kumar, D M Nikhila Kashyap, Suraj Hebbar, R Swetha, Sujay Prasad, T Kamala, S S Srikanta, P R Krishnaswamy, Navakanta Bhat
Direct Electron Transfer biosensors, facilitating direct communication between the biomolecule of interest and electrode surface, are preferable compared to enzymatic and mediator based sensors. Although hemoglobin (Hb) contains four redox active iron centres, direct detection is not possible due to inaccessibility of iron centres and formation of dimers, blocking electron transfer. Through the coordination of iron with aza-heterocyclic receptors - pyridine and imidazole - we report a cost effective, highly sensitive and simple electrochemical Hb sensor using cyclic voltammetry and chronoamperometry...
February 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28114456/financial-conflicts-of-interest-among-hematologist-oncologists-on-twitter
#13
Derrick L Tao, Aaron Boothby, Joel McLouth, Vinay Prasad
No abstract text is available yet for this article.
March 1, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/27941917/oxidative-stress-and-carbon-metabolism-influence-aspergillus-flavus-transcriptome-composition-and-secondary-metabolite-production
#14
Jake C Fountain, Prasad Bajaj, Manish Pandey, Spurthi N Nayak, Liming Yang, Vinay Kumar, Ashwin S Jayale, Anu Chitikineni, Weijian Zhuang, Brian T Scully, R Dewey Lee, Robert C Kemerait, Rajeev K Varshney, Baozhu Guo
Contamination of crops with aflatoxin is a serious global threat to food safety. Aflatoxin production by Aspergillus flavus is exacerbated by drought stress in the field and by oxidative stress in vitro. We examined transcriptomes of three toxigenic and three atoxigenic isolates of A. flavus in aflatoxin conducive and non-conducive media with varying levels of H2O2 to investigate the relationship of secondary metabolite production, carbon source, and oxidative stress. We found that toxigenic and atoxigenic isolates employ distinct mechanisms to remediate oxidative damage, and that carbon source affected the isolates' expression profiles...
December 12, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27892992/overall-survival-in-cancer-drug-trials-as-a-new-surrogate-end-point-for-overall-survival-in-the-real-world
#15
Sham Mailankody, Vinay Prasad
No abstract text is available yet for this article.
November 17, 2016: JAMA Oncology
https://www.readbyqxmd.com/read/27882660/pediatric-dermatology-photoquiz-an-enlarging-facial-papule
#16
Daniel A Yanes, Vinay Prasad, Esteban Fernandez Faith
No abstract text is available yet for this article.
November 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27847626/correlation-of-biomarkers-thiobarbituric-acid-reactive-substance-nitric-oxide-and-central-subfield-and-cube-average-thickness-in-diabetic-retinopathy-a-cross-sectional-study
#17
Surabhi Ruia, Sandeep Saxena, S Prasad, Shashi R Sharma, Levent Akduman, Vinay K Khanna
BACKGROUND: To evaluate the role of thiobarbituric acid reactive substance (TBARS) and nitric oxide (NO) as biochemical biomarkers and central subfield (CST) and cube average thickness (CAT) as biomarkers for medical imaging in diabetic retinopathy. METHODS: Forty consecutive cases of diabetic retinopathy and 20 healthy controls were included. Cases were divided into two groups: non proliferative diabetic retinopathy (n = 20) and proliferative diabetic retinopathy (n = 20) according to ETDRS classification...
2016: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/27787285/heparin-induced-thrombocytopenia-a-tremendous-opportunity-for-randomization
#18
Austin Lammers, Thomas DeLoughery, Vinay Prasad
: Heparin-induced thrombocytopenia and thrombosis (HITT) is both life-threatening with a complex immune-mediated process and clinically challenging to diagnose and treat. What further complicates matters is that thrombocytopenia is a frequently encountered laboratory value but rarely results in clinical signs of HITT. Decades into its initial description, we have anticoagulants with a small therapeutic index and associated high cost. The diagnosis is sometimes equivocal given our current laboratory diagnostics, and can take days to confirm...
April 2017: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/27782770/new-experimental-models-of-the-blood-brain-barrier-for-cns-drug-discovery
#19
REVIEW
Mohammad A Kaisar, Ravi K Sajja, Shikha Prasad, Vinay V Abhyankar, Taylor Liles, Luca Cucullo
The blood-brain barrier (BBB) is a dynamic biological interface which actively controls the passage of substances between the blood and the central nervous system (CNS). From a biological and functional standpoint, the BBB plays a crucial role in maintaining brain homeostasis inasmuch that deterioration of BBB functions are prodromal to many CNS disorders. Conversely, the BBB hinders the delivery of drugs targeting the brain to treat a variety of neurological diseases. Area covered: This article reviews recent technological improvements and innovation in the field of BBB modeling including static and dynamic cell-based platforms, microfluidic systems and the use of stem cells and 3D printing technologies...
January 2017: Expert Opinion on Drug Discovery
https://www.readbyqxmd.com/read/27760186/deciphering-transcriptional-programming-during-pod-and-seed-development-using-rna-seq-in-pigeonpea-cajanus-cajan
#20
Lekha T Pazhamala, Gaurav Agarwal, Prasad Bajaj, Vinay Kumar, Akanksha Kulshreshtha, Rachit K Saxena, Rajeev K Varshney
Seed development is an important event in plant life cycle that has interested humankind since ages, especially in crops of economic importance. Pigeonpea is an important grain legume of the semi-arid tropics, used mainly for its protein rich seeds. In order to understand the transcriptional programming during the pod and seed development, RNA-seq data was generated from embryo sac from the day of anthesis (0 DAA), seed and pod wall (5, 10, 20 and 30 DAA) of pigeonpea variety "Asha" (ICPL 87119) using Illumina HiSeq 2500...
2016: PloS One
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