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https://www.readbyqxmd.com/read/28817761/is-do-everything-always-appropriate-reply
#1
Tomasz M Beer, Vinay Prasad
No abstract text is available yet for this article.
August 17, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28750129/pemetrexed-in-nonsquamous-non-small-cell-lung-cancer-the-billion-dollar-subgroup-analysis
#2
Bishal Gyawali, Vinay Prasad
No abstract text is available yet for this article.
July 27, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28732060/formation-of-singlet-oxygen-by-decomposition-of-protein-hydroperoxide-in-photosystem-ii
#3
Vinay Pathak, Ankush Prasad, Pavel Pospíšil
Singlet oxygen (1O2) is formed by triplet-triplet energy transfer from triplet chlorophyll to O2 via Type II photosensitization reaction in photosystem II (PSII). Formation of triplet chlorophyll is associated with the change in spin state of the excited electron and recombination of triplet radical pair in the PSII antenna complex and reaction center, respectively. Here, we have provided evidence for the formation of 1O2 by decomposition of protein hydroperoxide in PSII membranes deprived of Mn4O5Ca complex...
2017: PloS One
https://www.readbyqxmd.com/read/28728605/surrogate-endpoints-in-oncology-when-are-they-acceptable-for-regulatory-and-clinical-decisions-and-are-they-currently-overused
#4
Robert Kemp, Vinay Prasad
BACKGROUND: Surrogate outcomes are not intrinsically beneficial to patients, but are designed to be easier and faster to measure than clinically meaningful outcomes. The use of surrogates as an endpoint in clinical trials and basis for regulatory approval is common, and frequently exceeds the guidance given by regulatory bodies. DISCUSSION: In this article, we demonstrate that the use of surrogates in oncology is widespread and increasing. At the same time, the strength of association between the surrogates used and clinically meaningful outcomes is often unknown or weak...
July 21, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28727973/pediatric-xanthogranulomatous-cystitis-the-first-described-case-in-a-pre-pubertal-male-and-review-of-the-literature
#5
Janae Preece, Vinay Prasad, Daryl McLeod
Xanthogranulomatous cystitis (XC) is a rare condition affecting the bladder thought to be caused by chronic inflammation. Fewer than 30 cases have been reported in the literature since being first described in 1932. We present the first reported case of XC in a pre-pubertal male and review the literature. A 10-year-old boy presenting with dysuria subsequently developed frequency. After failure of conservative management, an ultrasound of the bladder revealed a mass. The patient underwent partial cystectomy...
July 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/28719584/health-policy-me-too-drugs-with-limited-benefits-the-tale-of-regorafenib-for-hcc
#6
Bishal Gyawali, Vinay Prasad
No abstract text is available yet for this article.
July 18, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28715568/overestimating-the-benefit-of-cancer-drugs
#7
Vinay Prasad
No abstract text is available yet for this article.
July 13, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28672361/limitations-concerning-the-association-of-physician-sex-and-patient-outcomes
#8
Mark W Friedberg, Walid F Gellad, Vinay Prasad
No abstract text is available yet for this article.
July 1, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28662268/pembrolizumab-as-first-line-therapy-in-programmed-death-ligand-1-positive-advanced-lung-cancer-is-it-as-effective-as-we-think-it-is
#9
Daniel A Goldstein, Usama Bilal, Vinay Prasad
No abstract text is available yet for this article.
June 29, 2017: Cancer
https://www.readbyqxmd.com/read/28566059/the-effect-of-endograft-device-on-patient-outcomes-in-endovascular-repair-of-ruptured-abdominal-aortic-aneurysms
#10
Vinay Kansal, Sudhir Nagpal, Prasad Jetty
Objective Endovascular aneurysm repair for ruptured abdominal aortic aneurysm is being increasingly applied as the intervention of choice. The purpose of this study was to determine whether survival and reintervention rates after ruptured abdominal aortic aneurysm vary between endograft devices. Methods This cohort study identified all ruptured abdominal aortic aneurysms performed at The Ottawa Hospital from January 1999 to May 2015. Data collected included patient demographics, stability index at presentation, adherence to device instructions for use, endoleaks, reinterventions, and mortality...
January 1, 2017: Vascular
https://www.readbyqxmd.com/read/28550899/combined-effect-of-substance-p-and-curcumin-on-cutaneous-wound-healing-in-diabetic-rats
#11
Vinay Kant, Dinesh Kumar, Raju Prasad, Anu Gopal, Nitya N Pathak, Pawan Kumar, Surender K Tandan
BACKGROUND: Our earlier studies demonstrated that topically applied substance P (SP) or curcumin on excision skin wound accelerated the wound healing in streptozotocin-induced diabetic rats. In the present study, we aimed to evaluate the wound healing potential of combination of SP and curcumin in diabetic rats. MATERIALS AND METHODS: Open cutaneous excision wound was created on the back of each of the 60 diabetic rats. Wound-inflicted rats were equally divided into three groups namely, control, gel treated, and SP + curcumin treated...
May 15, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28543414/closed-financial-loops-when-they-happen-in-government-they-re-called-corruption-in-medicine-they-re-just-a-footnote
#12
Kevin De Jesus-Morales, Vinay Prasad
Many physicians are involved in relationships that create tension between a physician's duty to work in her patients' best interest at all times and her financial arrangement with a third party, most often a pharmaceutical manufacturer, whose primary goal is maximizing sales or profit. Despite the prevalence of this threat, in the United States and globally, the most common reaction to conflicts of interest in medicine is timid acceptance. There are few calls for conflicts of interest to be banned, and, to our knowledge, no one calls for conflicted practitioners to be reprimanded...
May 2017: Hastings Center Report
https://www.readbyqxmd.com/read/28534528/combining-drugs-and-extending-treatment-a-pfs-end-point-is-not-sufficient
#13
Bishal Gyawali, Vinay Prasad
No abstract text is available yet for this article.
May 23, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28520871/pharmaceutical-marketing-for-rare-diseases-regulating-drug-company-promotion-in-an-era-of-unprecedented-advertisement
#14
Sham Mailankody, Vinay Prasad
No abstract text is available yet for this article.
June 27, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28508688/extrarenal-wilms-tumor-with-skeletal-and-glial-differentiation
#15
Geok Chin Tan, Vinay Prasad
No abstract text is available yet for this article.
May 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28430952/a-strategy-for-helicobacter-immunohistochemistry-utilization-in-pediatric-practice-%C3%A2-insights-from-morphologic-and-cost-benefit-analyses
#16
Miriam R Conces, Christina A Arnold, Peter B Baker, Christopher M Carter, Bonita Fung, Vinay Prasad, Michael A Arnold
Objectives: Recent studies in adults have examined the utility of immunohistochemistry (IHC) in detecting Helicobacter in gastric biopsy specimens and reached differing conclusions. Dedicated cost-benefit analysis of Helicobacter IHC in pediatric gastric biopsy specimens has not been performed. Methods: From 1,955 pediatric gastric biopsies in a 1-year period, we identified 63 Helicobacter -positive and 120 Helicobacter -negative biopsy specimens. All cases were scored according to the Updated Sydney System for the severity of inflammation...
November 1, 2016: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28395768/what-constitutes-an-unmet-medical-need-in-oncology-an-empirical-evaluation-of-author-usage-in-the-biomedical-literature
#17
Eric Lu, Joseph Shatzel, Florence Shin, Vinay Prasad
The phrase "unmet medical need" has important regulatory implications, but there is no empirical analysis of its real world usage. We sought to determine the annual US incidence, 5-year survival, and number of National Comprehensive Cancer Network (NCCN)-recommended regimens for indications described in the literature as an "unmet medical need." We queried Google Scholar to identify publications where authors used the phrase "unmet medical need" to refer to a specific cancer indication. For each indication, we investigated the annual US incidence, 5-year survival, and number of NCCN recommended regimens...
February 2017: Seminars in Oncology
https://www.readbyqxmd.com/read/28344145/how-the-uspstf-s-mammographic-screening-guidelines-should-be-interpreted
#18
EDITORIAL
Vinay Prasad
No abstract text is available yet for this article.
March 24, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28290490/the-high-price-of-anticancer-drugs-origins-implications-barriers-solutions
#19
REVIEW
Vinay Prasad, Kevin De Jesús, Sham Mailankody
Globally, annual spending on anticancer drugs is around US$100 billion, and is predicted to rise to $150 billion by 2020. In the USA, a novel anticancer drug routinely costs more than $100,000 per year of treatment. When adjusted for per capita spending power, however, drugs are most unaffordable in economically developing nations, such as India and China. Not only are launch prices high and rising, but individual drug prices are often escalated during exclusivity periods. High drug prices harm patients - often directly through increased out-of-pocket expenses, which reduce levels of patient compliance and lead to unfavourable outcomes - and harms society - by imposing cumulative price burdens that are unsustainable...
June 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28266519/drugs-that-lack-single-agent-activity-are-they-worth-pursuing-in-combination
#20
Bishal Gyawali, Vinay Prasad
No abstract text is available yet for this article.
April 2017: Nature Reviews. Clinical Oncology
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