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https://www.readbyqxmd.com/read/27913820/cerebral-blood-flow-transit-time-and-apparent-diffusion-coefficient-in-moyamoya-disease-before-and-after-acetazolamide
#1
Christian Federau, Soren Christensen, Zungho Zun, Sun-Won Park, Wendy Ni, Michael Moseley, Greg Zaharchuk
INTRODUCTION: The goal of this study was to assess the changes in arterial spin labeling (ASL) cerebral blood flow (CBF) and arterial transit time (ATT), and in apparent diffusion coefficient (ADC), before and after an acetazolamide challenge in moyamoya patients, as function of arterial stenosis severity. METHODS: Pre-operative patients diagnosed with moyamoya disease who could undergo MRI at 3.0T were recruited for this study. A multi-delay pseudo-continuous ASL and a diffusion-weighted sequence were acquired before and 15 min after acetazolamide injection...
December 2, 2016: Neuroradiology
https://www.readbyqxmd.com/read/27904230/the-tidier-checklist-will-benefit-the-physiotherapy-profession
#2
EDITORIAL
Tie Yamato, Chris Maher, Bruno Saragiotto, Anne Moseley, Tammy Hoffmann, Mark Elkins, Dina Brooks
No abstract text is available yet for this article.
2016: Physiotherapy Canada. Physiothérapie Canada
https://www.readbyqxmd.com/read/27899009/concise-xanthine-synthesis-via-a-double-amidination-reaction-of-a-6-chlorouracil-with-amidines-using-base-metal-catalysis
#3
Bénédicte Morel, Philippe Franck, Johan Bidange, Sergey Sergeyev, Dan Smith, Jonathan Moseley, Bert Uw Maes
A novel and concise route towards xanthines via a double amidination reaction is described; consecutive intermolecular C-Cl and intramolecular oxidative C-H amidination. N-uracil amidines are obtained via SNAE on a 6-chlorouracil with amidines. Direct Cu-catalyzed oxidative C-H amidination on these N-uracil amidines yields polysubstituted xanthines. Sustainable oxidants, di-tert-butyl peroxide or oxygen, can be used in this oxidase type reaction. The protocol allows for the introduction of N1, N3, N7 and C8 substituents during the xanthine scaffold construction, thus avoiding post-functionalization steps...
November 29, 2016: ChemSusChem
https://www.readbyqxmd.com/read/27886941/management-of-musculoskeletal-pain-in-a-compensable-environment-implementation-of-helpful-and-unhelpful-models-of-care-in-supporting-recovery-and-return-to-work
#4
REVIEW
Darren Beales, Kal Fried, Michael Nicholas, Fiona Blyth, Damien Finniss, G Lorimer Moseley
Models of Care (MoCs) for injured workers in the compensation environment recommend adoption of biopsychosocial management approaches. Still, widespread dominance of biomedical constructs at the system, organisational and individual levels of the compensation system prevails, contributing to suboptimal management practices and outcomes for injured workers. Efforts to implement contemporary MoCs in the compensation environment show some promise in improving outcomes. Areas of promise at the organisational level, particularly in the workplace, and at the system level are discussed...
June 2016: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/27886561/the-stop-bang-questionnaire-improves-the-detection-of-epilepsy-patients-at-risk-for-obstructive-sleep-apnea
#5
Anumeha Sharma, Jennifer Molano, Brian D Moseley
Patients with epilepsy and obstructive sleep apnea (OSA) are at risk for worsened seizure control and quality of life. We performed a quality improvement project, evaluating for improvements in the screening of OSA in epilepsy patients using the STOP-BANG questionnaire. The electronic medical records of patients seen in our epilepsy clinic were screened for 4 months prior to the intervention. We subsequently implemented the STOP-BANG questionnaire for 3 months. Only 22/664 patients (3.3%) had their sleeping habits explored during the pre-intervention period; 11 (1...
November 18, 2016: Epilepsy Research
https://www.readbyqxmd.com/read/27884861/diagnostic-accuracy-of-the-ottawa-ankle-and-midfoot-rules-a-systematic-review-with-meta-analysis
#6
Paula R Beckenkamp, Chung-Wei Christine Lin, Petra Macaskill, Zoe A Michaleff, Chris G Maher, Anne M Moseley
OBJECTIVE: To review the diagnostic accuracy of the Ottawa Ankle and Midfoot Rules and explore if clinical features and/or methodological quality of the study influence diagnostic accuracy estimates. DESIGN: Systematic review with meta-analysis. DATA SOURCES: MEDLINE, EMBASE, CINAHL, SPORTDiscus and Cochrane Library. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Primary diagnostic studies reporting the accuracy of the Rules in people with ankle and/or midfoot injury were retrieved...
November 24, 2016: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/27883015/mr-vascular-fingerprinting-in-stroke-and-brain-tumors-models
#7
B Lemasson, N Pannetier, N Coquery, Ligia S B Boisserand, Nora Collomb, N Schuff, M Moseley, G Zaharchuk, E L Barbier, T Christen
In this study, we evaluated an MRI fingerprinting approach (MRvF) designed to provide high-resolution parametric maps of the microvascular architecture (i.e., blood volume fraction, vessel diameter) and function (blood oxygenation) simultaneously. The method was tested in rats (n = 115), divided in 3 models: brain tumors (9 L, C6, F98), permanent stroke, and a control group of healthy animals. We showed that fingerprinting can robustly distinguish between healthy and pathological brain tissues with different behaviors in tumor and stroke models...
November 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27875480/innovative-treatments-for-back-pain
#8
G Lorimer Moseley
Innovation involves asking new questions, or taking new approaches to old questions. For a problem as old as back pain, one might expect innovations to be rare. That back pain has been the most burdensome non-fatal health condition for over 25 years, and that the treatments that are available are not very effective, clearly points to the need for innovative approaches. The most eye-catching innovations of the last decade have taken novel approaches to the intervertebral disk, but the disconnect between back pain and structural pathology of the spine suggest that the impact of any so targeted approaches will be limited...
November 21, 2016: Pain
https://www.readbyqxmd.com/read/27870603/indirect-comparison-of-novel-oral-anticoagulants-in-women-with-nonvalvular-atrial-fibrillation
#9
Alex Moseley, Rami Doukky, Kim Allan Williams, Amir K Jaffer, Annabelle Santos Volgman
BACKGROUND: For nonvalvular atrial fibrillation (NVAF), novel oral anticoagulants (NOACs) have been found noninferior to warfarin for stroke/systemic embolization prevention, and major bleeding events. Recent meta-analysis of NOACs versus warfarin in atrial fibrillation (AF) showed that women on warfarin have greater risk of stroke/embolism than men, and when both are treated with NOACs, differences disappear. METHODS: NOACs differ in pharmacologic properties, thus they may differ from one another in their effects on women with AF...
November 21, 2016: Journal of Women's Health
https://www.readbyqxmd.com/read/27856785/chronic-obstructive-pulmonary-disease-phenotypes-using-cluster-analysis-of-electronic-medical-records
#10
Rodrigo Vazquez Guillamet, Oleg Ursu, Gary Iwamoto, Pope L Moseley, Tudor Oprea
Chronic obstructive pulmonary disease is a heterogeneous disease. In this retrospective study, we hypothesize that it is possible to identify clinically relevant phenotypes by applying clustering methods to electronic medical records. We included all the patients >40 years with a diagnosis of chronic obstructive pulmonary disease admitted to the University of New Mexico Hospital between 1 January 2011 and 1 May 2014. We collected admissions, demographics, comorbidities, severity markers and treatments...
November 17, 2016: Health Informatics Journal
https://www.readbyqxmd.com/read/27846529/response-to-comments-on-reconciliation-of-the-devils-hole-climate-record-with-orbital-forcing
#11
Gina E Moseley, Yuri V Dublyansky, R Lawrence Edwards, Kathleen A Wendt, Mathieu Pythoud, Pu Zhang, Hai Cheng, Yanbin Lu, Ronny Boch, Christoph Spötl
Winograd and Coplen question the thorium-230 distribution model proposed to explain the age bias observed with increasing depth during Termination II. We have evaluated both criticisms and find that all samples display virtually identical fabrics, argue that the modern setting is not analogous to the conditions during Termination II, and reiterate the robustness of our age models. Our conclusions remain unchanged.
October 21, 2016: Science
https://www.readbyqxmd.com/read/27846528/comment-on-reconciliation-of-the-devils-hole-climate-record-with-orbital-forcing
#12
Tyler B Coplen
Moseley et al's (Reports, 8 January 2016, p. 165) preferred-Termination-II age is subjective, as evidenced by variation in their Termination-II ages of 2500 years per meter. Termination-II-age bias decreases to zero at ~1.5 meters below the present-day water table, if one assumes linear variation with core-sample height. Maintaining the required gradient of thorium isotope (230)Th over 3.6 meters for 1000 years, much less 10,000 years, seems exceedingly unlikely.
October 21, 2016: Science
https://www.readbyqxmd.com/read/27846527/comment-on-reconciliation-of-the-devils-hole-climate-record-with-orbital-forcing
#13
Isaac J Winograd
Moseley et al (Reports, 8 January 2016, p. 165) postulate an increase in dissolved thorium isotope (230)Th with depth below the water table as the explanation for the differing ages of Termination II. Flow of geothermal water through the Devils Hole caverns precludes this explanation. Deposition of younger secondary calcite into the initial porosity of the calcite comprising their cores is a plausible alternate explanation.
October 21, 2016: Science
https://www.readbyqxmd.com/read/27837137/perfecting-the-l5-s1-spot-projection
#14
Susie Moseley
No abstract text is available yet for this article.
November 2016: Radiologic Technology
https://www.readbyqxmd.com/read/27812043/diagnosis-trajectories-of-prior-multi-morbidity-predict-sepsis-mortality
#15
Mette K Beck, Anders Boeck Jensen, Annelaura Bach Nielsen, Anders Perner, Pope L Moseley, Søren Brunak
Sepsis affects millions of people every year, many of whom will die. In contrast to current survival prediction models for sepsis patients that primarily are based on data from within-admission clinical measurements (e.g. vital parameters and blood values), we aim for using the full disease history to predict sepsis mortality. We benefit from data in electronic medical records covering all hospital encounters in Denmark from 1996 to 2014. This data set included 6.6 million patients of whom almost 120,000 were diagnosed with the ICD-10 code: A41 'Other sepsis'...
November 4, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27808237/timing-and-causes-of-north-african-wet-phases-during-the-last-glacial-period-and-implications-for-modern-human-migration
#16
Dirk L Hoffmann, Mike Rogerson, Christoph Spötl, Marc Luetscher, Derek Vance, Anne H Osborne, Nuri M Fello, Gina E Moseley
We present the first speleothem-derived central North Africa rainfall record for the last glacial period. The record reveals three main wet periods at 65-61 ka, 52.5-50.5 ka and 37.5-33 ka that lead obliquity maxima and precession minima. We find additional minor wet episodes that are synchronous with Greenland interstadials. Our results demonstrate that sub-tropical hydrology is forced by both orbital cyclicity and North Atlantic moisture sources. The record shows that after the end of a Saharan wet phase around 70 ka ago, North Africa continued to intermittently receive substantially more rainfall than today, resulting in favourable environmental conditions for modern human expansion...
November 3, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27778047/relative-contributions-of-spatial-weighting-explicit-knowledge-and-proprioception-to-hand-localisation-during-positional-ambiguity
#17
Valeria Bellan, Helen R Gilpin, Tasha R Stanton, Lilja K Dagsdóttir, Alberto Gallace, G Lorimer Moseley
When vision and proprioception are rendered incongruent during a hand localisation task, vision is initially weighted more than proprioception in determining location, and proprioception gains more weighting over time. However, it is not known whether, under these incongruency conditions, particular areas of space are also weighted more heavily than others, nor whether explicit knowledge of the sensory incongruence (i.e. disconfirming the perceived location of the hand) modulates the effect. Here, we hypothesised that both non-informative inputs coming from one side of space and explicit knowledge of sensory incongruence would modulate perceived location of the limb...
October 24, 2016: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/27721380/corrigendum-identification-of-altered-metabolomic-profiles-following-a-panchakarma-based-ayurvedic-intervention-in-healthy-subjects-the-self-directed-biological-transformation-initiative-sbti
#18
Christine Tara Peterson, Joseph Lucas, Lisa St John-Williams, J Will Thompson, M Arthur Moseley, Sheila Patel, Scott N Peterson, Valencia Porter, Eric E Schadt, Paul J Mills, Rudolph E Tanzi, P Murali Doraiswamy, Deepak Chopra
No abstract text is available yet for this article.
October 10, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27716646/modelling-topical-photodynamic-therapy-treatment-including-the-continuous-production-of-protoporphyrin-ix
#19
C L Campbell, C T A Brown, K Wood, H Moseley
Most existing theoretical models of photodynamic therapy (PDT) assume a uniform initial distribution of the photosensitive molecule, Protoporphyrin IX (PpIX). This is an adequate assumption when the prodrug is systematically administered; however for topical PDT this is no longer a valid assumption. Topical application and subsequent diffusion of the prodrug results in an inhomogeneous distribution of PpIX, especially after short incubation times, prior to light illumination. In this work a theoretical simulation of PDT where the PpIX distribution depends on the incubation time and the treatment modality is described...
October 7, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27709486/lower-extremity-growth-and-deformity
#20
REVIEW
Amanda T Whitaker, Carley Vuillermin
The pediatric lower extremity has well known growth patterns. When deformities or growth disturbances occur, there are several methods to measure and predict the resulting discrepancy, including the Green-Anderson, Moseley, and Multiplier methods. Many techniques exist to correct leg length discrepancy and deformity such and temporary epiphysiodesis, permanent epiphysiodesis, external fixators, and internal lengthening devices. All of these methods have numerous complications and limitations; however, with careful planning and patient selection, length and alignment can be improved with high patient satisfaction...
December 2016: Current Reviews in Musculoskeletal Medicine
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