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https://www.readbyqxmd.com/read/28345042/human-genetic-and-metabolite-variation-reveals-that-methylthioadenosine-is-a-prognostic-biomarker-and-an-inflammatory-regulator-in-sepsis
#1
Liuyang Wang, Emily R Ko, James J Gilchrist, Kelly J Pittman, Anna Rautanen, Matti Pirinen, J Will Thompson, Laura G Dubois, Raymond J Langley, Sarah L Jaslow, Raul E Salinas, D Clayburn Rouse, M Arthur Moseley, Salim Mwarumba, Patricia Njuguna, Neema Mturi, Thomas N Williams, J Anthony G Scott, Adrian V S Hill, Christopher W Woods, Geoffrey S Ginsburg, Ephraim L Tsalik, Dennis C Ko
Sepsis is a deleterious inflammatory response to infection with high mortality. Reliable sepsis biomarkers could improve diagnosis, prognosis, and treatment. Integration of human genetics, patient metabolite and cytokine measurements, and testing in a mouse model demonstrate that the methionine salvage pathway is a regulator of sepsis that can accurately predict prognosis in patients. Pathway-based genome-wide association analysis of nontyphoidal Salmonella bacteremia showed a strong enrichment for single-nucleotide polymorphisms near the components of the methionine salvage pathway...
March 2017: Science Advances
https://www.readbyqxmd.com/read/28341160/metabolic-network-failures-in-alzheimer-s-disease-a-biochemical-road%C3%A2-map
#2
Jon B Toledo, Matthias Arnold, Gabi Kastenmüller, Rui Chang, Rebecca A Baillie, Xianlin Han, Madhav Thambisetty, Jessica D Tenenbaum, Karsten Suhre, J Will Thompson, Lisa St John-Williams, Siamak MahmoudianDehkordi, Daniel M Rotroff, John R Jack, Alison Motsinger-Reif, Shannon L Risacher, Colette Blach, Joseph E Lucas, Tyler Massaro, Gregory Louie, Hongjie Zhu, Guido Dallmann, Kristaps Klavins, Therese Koal, Sungeun Kim, Kwangsik Nho, Li Shen, Ramon Casanova, Sudhir Varma, Cristina Legido-Quigley, M Arthur Moseley, Kuixi Zhu, Marc Y R Henrion, Sven J van der Lee, Amy C Harms, Ayse Demirkan, Thomas Hankemeier, Cornelia M van Duijn, John Q Trojanowski, Leslie M Shaw, Andrew J Saykin, Michael W Weiner, P Murali Doraiswamy, Rima Kaddurah-Daouk
INTRODUCTION: The Alzheimer's Disease Research Summits of 2012 and 2015 incorporated experts from academia, industry, and nonprofit organizations to develop new research directions to transform our understanding of Alzheimer's disease (AD) and propel the development of critically needed therapies. In response to their recommendations, big data at multiple levels are being generated and integrated to study network failures in disease. We used metabolomics as a global biochemical approach to identify peripheral metabolic changes in AD patients and correlate them to cerebrospinal fluid pathology markers, imaging features, and cognitive performance...
March 21, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28302053/a-fast-and-efficient-python-library-for-interfacing-with-the-biological-magnetic-resonance-data-bank
#3
Andrey Smelter, Morgan Astra, Hunter N B Moseley
BACKGROUND: The Biological Magnetic Resonance Data Bank (BMRB) is a public repository of Nuclear Magnetic Resonance (NMR) spectroscopic data of biological macromolecules. It is an important resource for many researchers using NMR to study structural, biophysical, and biochemical properties of biological macromolecules. It is primarily maintained and accessed in a flat file ASCII format known as NMR-STAR. While the format is human readable, the size of most BMRB entries makes computer readability and explicit representation a practical requirement for almost any rigorous systematic analysis...
March 17, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28289863/a-phase-ii-study-of-reolysin-%C3%A2-pelareorep-in-combination-with-carboplatin-and-paclitaxel-for-patients-with-advanced-malignant-melanoma
#4
Devalingam Mahalingam, Christos Fountzilas, Jennifer Moseley, Nicole Noronha, Hue Tran, Romit Chakrabarty, Giovanni Selvaggi, Matthew Coffey, Brad Thompson, John Sarantopoulos
REOLYSIN(®) (pelareorep) is an investigational new drug, consisting of a live, replication-competent, Reovirus Type 3 Dearing strain in a proprietary formulation. Several preclinical and clinical trials with REOLYSIN(®) on a wide range of cancer indications have demonstrated antineoplastic activity on cells with activated RAS-signaling pathway. Furthermore, long-term survival benefits were evident in post-treatment patients indicating a potential antitumor immune response triggered by REOLYSIN(®). Numerous mono and/or combination therapy studies with the agent showed a consistent safety profile...
March 13, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28288916/the-pedro-scale-had-acceptably-high-convergent-validity-construct-validity-and-inter-rater-reliability-in-evaluating-methodological-quality-of-pharmaceutical-trials
#5
Tie Parma Yamato, Chris Maher, Bart Koes, Anne Moseley
INTRODUCTION: The Physiotherapy Evidence Database (PEDro) scale has been widely used to investigate methodological quality in physiotherapy randomised controlled trials; however its validity has not been tested for pharmaceutical trials. The aim of this study was to investigate the validity and inter-rater reliability of the PEDro scale for pharmaceutical trials. The reliability was also examined for the Cochrane Back and Neck (CBN) Group risk of bias tool. METHODS: This is a secondary analysis of data from a previous study...
March 10, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28284239/integrating-self-localization-proprioception-pain-and-performance
#6
Valeria Bellan, Sarah B Wallwork, Alberto Gallace, Charles Spence, G Lorimer Moseley
The ability to know where our own body and body parts are in space is often taken for granted, yet it is of fundamental importance for the majority of our everyday activities, let alone high performance activities such as dancing. This review focuses on the concept of self-localization, the monitoring of the space surrounding one's body, and the disruptions that occur in the presence of pain. A conceptual model is presented of the cortical body matrix with which to consider self-localization; also provided are its historical context, underlying assumptions, and current limitations...
March 1, 2017: Journal of Dance Medicine & Science
https://www.readbyqxmd.com/read/28284238/applying-current-concepts-in-pain-related-brain-science-to-dance-rehabilitation
#7
Sarah B Wallwork, Valeria Bellan, G Lorimer Moseley
Dance involves exemplary sensory-motor control, which is subserved by sophisticated neural processing at the spinal cord and brain level. Such neural processing is altered in the presence of nociception and pain, and the adaptations within the central nervous system that are known to occur with persistent nociception or pain have clear implications for movement and, indeed, risk of further injury. Recent rapid advances in our understanding of the brain's representation of the body and the role of cortical representations, or "neurotags," in bodily protection and regulation have given rise to new strategies that are gaining traction in sports medicine...
March 1, 2017: Journal of Dance Medicine & Science
https://www.readbyqxmd.com/read/28272970/wee1-and-cdc25-tools-pathways-mechanisms-questions
#8
James B Moseley
No abstract text is available yet for this article.
March 8, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28263141/use-of-blood-donor-screening-data-to-estimate-zika-virus-incidence-puerto-rico-april-august-2016
#9
Michelle S Chevalier, Brad J Biggerstaff, Sridhar V Basavaraju, M Cheryl Bañez Ocfemia, Jose O Alsina, Consuelo Climent-Peris, Robin R Moseley, Koo-Whang Chung, Brenda Rivera-García, Melissa Bello-Pagán, Lisa L Pate, Susan A Galel, Phillip Williamson, Matthew J Kuehnert
Puerto Rico has been heavily impacted by Zika virus, a mosquitoborne flavivirus that emerged in the Americas during 2015. Although most persons with Zika virus show no symptoms, the virus can cause neurologic and other complications, including fetal microcephaly. Local Zika virus transmission in Puerto Rico has been reported since December 2015. To prevent transfusion-associated transmission, local blood collection ceased in March 2016 but resumed in April 2016 after Zika virus screening of blood donations became available...
May 15, 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28257944/a-quantitative-study-of-in-vivo-protoporphyrin-ix-fluorescence-build-up-during-occlusive-treatment-phases
#10
C Louise Campbell, C Tom A Brown, Kenneth Wood, Ana Gabriela Salvio, Natalia M Inada, Vanderlei S Bagnato, Harry Moseley
BACKGROUND: Topical photodynamic therapy (PDT) is a non-invasive light based therapy used to treat non-melanoma skin cancer (NMSC) and dysplasia. During PDT, the light sensitive molecule protoporphyrin IX (PpIX) is activated, resulting in the production of singlet oxygen, which subsequently leads to cell death. PpIX is metabolised from a topically applied pro-drug and the strong fluorescence signal associated with PpIX can be utilised as an indicator of the amount of PpIX present within the tumour tissue...
February 28, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28248614/relevant-research-from-non-orthodontic-journals
#11
Sara Stephens, Howard Moseley
No abstract text is available yet for this article.
March 2017: Journal of Orthodontics
https://www.readbyqxmd.com/read/28248570/the-diacetyl-exposed-human-airway-epithelial-secretome-new-insights-into-flavoring-induced-airways-disease
#12
David M Brass, William M Gwinn, Ashlee M Valente, Francine L Kelly, Christie D Brinkley, Andrew E Nagler, M Arthur Moseley, Daniel L Morgan, Scott M Palmer, Matthew W Foster
Bronchiolitis obliterans (BO) is an increasingly important lung disease characterized by fibroproliferative airway lesions and decrements in lung function. Occupational exposure to the artificial food flavoring ingredient diacetyl, commonly used to impart a buttery flavor to microwave popcorn, has been associated with BO development. In the occupational setting, diacetyl vapor is first encountered by the airway epithelium. To better understand the effects of diacetyl vapor on the airway epithelium we used an unbiased proteomic approach to characterize both the apical and basolateral secretomes of air liquid interface cultures of primary human airway epithelial cells from four unique donors after exposure to an occupationally relevant ~1100 ppm of diacetyl vapor or PBS as a control on alternating days...
March 1, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/28243537/using-visuo-kinetic-virtual-reality-to-induce-illusory-spinal-movement-the-moovi-illusion
#13
Daniel S Harvie, Ross T Smith, Estin V Hunter, Miles G Davis, Michele Sterling, G Lorimer Moseley
BACKGROUND: Illusions that alter perception of the body provide novel opportunities to target brain-based contributions to problems such as persistent pain. One example of this, mirror therapy, uses vision to augment perceived movement of a painful limb to treat pain. Since mirrors can't be used to induce augmented neck or other spinal movement, we aimed to test whether such an illusion could be achieved using virtual reality, in advance of testing its potential therapeutic benefit. We hypothesised that perceived head rotation would depend on visually suggested movement...
2017: PeerJ
https://www.readbyqxmd.com/read/28238781/caspofungin-exposure-alters-the-core-septin-aspb-interactome-of-aspergillus-fumigatus
#14
José M Vargas-Muñiz, Hilary Renshaw, Greg Waitt, Erik J Soderblom, M Arthur Moseley, Jonathan M Palmer, Praveen R Juvvadi, Nancy P Keller, William J Steinbach
Aspergillus fumigatus, the main etiological agent of invasive aspergillosis, is a leading cause of death in immunocompromised patients. Septins, a conserved family of GTP-binding proteins, serve as scaffolding proteins to recruit enzymes and key regulators to different cellular compartments. Deletion of the A. fumigatus septin aspB increases susceptibility to the echinocandin antifungal caspofungin. However, how AspB mediates this response to caspofungin is unknown. Here, we characterized the AspB interactome under basal conditions and after exposure to a clinically relevant concentration of caspofungin...
April 1, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28238698/nasopharyngeal-protein-biomarkers-of-acute-respiratory-virus-infection
#15
Thomas W Burke, Ricardo Henao, Erik Soderblom, Ephraim L Tsalik, J Will Thompson, Micah T McClain, Marshall Nichols, Bradly P Nicholson, Timothy Veldman, Joseph E Lucas, M Arthur Moseley, Ronald B Turner, Robert Lambkin-Williams, Alfred O Hero, Christopher W Woods, Geoffrey S Ginsburg
Infection of respiratory mucosa with viral pathogens triggers complex immunologic events in the affected host. We sought to characterize this response through proteomic analysis of nasopharyngeal lavage in human subjects experimentally challenged with influenza A/H3N2 or human rhinovirus, and to develop targeted assays measuring peptides involved in this host response allowing classification of acute respiratory virus infection. Unbiased proteomic discovery analysis identified 3285 peptides corresponding to 438 unique proteins, and revealed that infection with H3N2 induces significant alterations in protein expression...
February 21, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28223368/phosphatases-generate-signal-specificity-downstream-of-ssp1-kinase-in-fission-yeast
#16
Lin Deng, Mid Eum Lee, Katherine Schutt, James B Moseley
AMPK-related protein kinases (ARKs) coordinate cell growth, proliferation, and migration with environmental status. It is unclear how specific ARKs are activated at specific times. In fission yeast S. pombe, the CaMKK-like protein kinase Ssp1 promotes cell cycle progression by activating the ARK Cdr2 according to cell growth signals. Here, we demonstrate that Ssp1 activates a second ARK, Ssp2/AMPK-α, for cell proliferation in low environmental glucose. Ssp1 activates these two related targets by the same biochemical mechanism: direct phosphorylation of a conserved residue in the activation loop (Cdr2-T166 and Ssp2-T189)...
February 21, 2017: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/28213515/hendra-virus-fusion-protein-transmembrane-domain-contributes-to-pre-fusion-protein-stability
#17
Stacy Webb, Tamas Nagy, Hunter Moseley, Michael Fried, Rebecca Ellis Dutch
Enveloped viruses utilize fusion (F) proteins studding the surface of the virus to facilitate membrane fusion with a target cell membrane. Fusion of the viral envelope with a cellular membrane is required for release of viral genomic material so the virus can ultimately reproduce and spread. To drive fusion, the F protein undergoes an irreversible conformational change, transitioning from a meta-stable pre-fusion conformation to a more thermodynamically stable post-fusion structure. Understanding the elements which control stability of the pre-fusion state and triggering to the post-fusion conformation is important for understanding F protein function...
February 17, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28209149/erratum-to-can-screening-instruments-accurately-determine-poor-outcome-risk-in-adults-with-recent-onset-low-back-pain-a-systematic-review-and-meta-analysis
#18
Emma L Karran, James H McAuley, Adrian C Traeger, Susan L Hillier, Luzia Grabherr, Leslie N Russek, G Lorimer Moseley
No abstract text is available yet for this article.
February 17, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28187665/land-flatworms-platyhelminthes-geoplanidae-of-s%C3%A3-o-tom%C3%A3-%C3%A2-a-first-account-on-their-diversity-with-the-description-of-five-new-species
#19
Ronald Sluys, Matthias Neumann, Ricardo F DE Lima, Robert C Drewes
The present contribution provides the first faunistic and taxonomic account of six species of land flatworm from the island of São Tomé, including five new species of the genus Othelosoma Gray, 1869 and the introduced Bipalium kewense Moseley, 1878. One of the new species represents the first African land flatworm that has specks on its dorsal body surface, instead of stripes or a more or less uniform colouration. At least two of the new species were observed to prey on snails. The study details the fourth record of a sclerotic spermatophore in a species of land flatworm, and discusses the definition and homology of double female genital canals in African and Indian species of the genus Othelosoma...
January 17, 2017: Zootaxa
https://www.readbyqxmd.com/read/28174315/a-novel-phosphoregulatory-switch-controls-the-activity-and-function-of-the-major-catalytic-subunit-of-protein-kinase-a-in-aspergillus-fumigatus
#20
E Keats Shwab, Praveen R Juvvadi, Greg Waitt, Erik J Soderblom, M Arthur Moseley, Nathan I Nicely, Yohannes G Asfaw, William J Steinbach
Invasive aspergillosis (IA), caused by the filamentous fungal pathogen Aspergillus fumigatus, is a major cause of death among immunocompromised patients. The cyclic AMP/protein kinase A (PKA) signaling pathway is essential for hyphal growth and virulence of A. fumigatus, but the mechanism of regulation of PKA remains largely unknown. Here, we discovered a novel mechanism for the regulation of PKA activity in A. fumigatus via phosphorylation of key residues within the major catalytic subunit, PkaC1. Phosphopeptide enrichment and tandem mass spectrometry revealed the phosphorylation of PkaC1 at four sites (S175, T331, T333, and T337) with implications for important and diverse roles in the regulation of A...
February 7, 2017: MBio
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