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Christine Tara Peterson, Joseph Lucas, Lisa St John-Williams, J Will Thompson, M Arthur Moseley, Sheila Patel, Scott N Peterson, Valencia Porter, Eric E Schadt, Paul J Mills, Rudolph E Tanzi, P Murali Doraiswamy, Deepak Chopra
No abstract text is available yet for this article.
October 10, 2016: Scientific Reports
C L Campbell, C T A Brown, K Wood, H Moseley
Most existing theoretical models of photodynamic therapy (PDT) assume a uniform initial distribution of the photosensitive molecule, Protoporphyrin IX (PpIX). This is an adequate assumption when the prodrug is systematically administered; however for topical PDT this is no longer a valid assumption. Topical application and subsequent diffusion of the prodrug results in an inhomogeneous distribution of PpIX, especially after short incubation times, prior to light illumination. In this work a theoretical simulation of PDT where the PpIX distribution depends on the incubation time and the treatment modality is described...
October 7, 2016: Physics in Medicine and Biology
Amanda T Whitaker, Carley Vuillermin
The pediatric lower extremity has well known growth patterns. When deformities or growth disturbances occur, there are several methods to measure and predict the resulting discrepancy, including the Green-Anderson, Moseley, and Multiplier methods. Many techniques exist to correct leg length discrepancy and deformity such and temporary epiphysiodesis, permanent epiphysiodesis, external fixators, and internal lengthening devices. All of these methods have numerous complications and limitations; however, with careful planning and patient selection, length and alignment can be improved with high patient satisfaction...
October 5, 2016: Current Reviews in Musculoskeletal Medicine
Michael P Whyte, Katherine L Madson, Dawn Phillips, Amy L Reeves, William H McAlister, Amy Yakimoski, Karen E Mack, Kim Hamilton, Kori Kagan, Kenji P Fujita, David D Thompson, Scott Moseley, Tatjana Odrljin, Cheryl Rockman-Greenberg
Background. Hypophosphatasia (HPP) is caused by loss-of-function mutation(s) of the gene that encodes the tissue-nonspecific isoenzyme of alkaline phosphatase (TNSALP). Consequently, cell-surface deficiency of TNSALP phosphohydrolase activity leads to extracellular accumulation of inorganic pyrophosphate, a natural substrate of TNSALP and inhibitor of mineralization. Children with HPP can manifest rickets, skeletal pain, deformity, fracture, muscle weakness, and premature deciduous tooth loss. Asfotase alfa is a recombinant, bone-targeted, human TNSALP injected s...
June 16, 2016: JCI Insight
Victoria J Madden, Leslie N Russek, Daniel S Harvie, Johan W S Vlaeyen, G Lorimer Moseley
OBJECTIVE : Associative learning has been proposed as a mechanism behind the persistence of pain after tissue healing. The simultaneous occurrence of nociceptive and non-nociceptive input during acute injury mimics the pairings thought to drive classical conditioning effects. However, empirical evidence for classically conditioned allodynia is lacking. We aimed to manipulate pain thresholds with a classical conditioning procedure that used non-nociceptive somatosensory stimuli as conditioned stimuli (CS) and nociceptive stimuli as unconditioned stimuli...
September 28, 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
(no author information available yet)
This section is designed to draw the attention of readers to papers that have been published in non-orthodontic journals and that may be of interest. The abstracts have been selected and edited by Sara Stephens and Howard Moseley.
August 16, 2016: Journal of Orthodontics
Kirsten S Evonuk, Carson E Moseley, Ryan E Doyle, Casey T Weaver, Tara M DeSilva
A major hallmark of the autoimmune demyelinating disease multiple sclerosis (MS) is immune cell infiltration into the brain and spinal cord resulting in myelin destruction, which not only slows conduction of nerve impulses, but causes axonal injury resulting in motor and cognitive decline. Current treatments for MS focus on attenuating immune cell infiltration into the central nervous system (CNS). These treatments decrease the number of relapses, improving quality of life, but do not completely eliminate relapses so long-term disability is not improved...
2016: Journal of Visualized Experiments: JoVE
Hesamoddin Jahanian, Thomas Christen, Michael E Moseley, Nicholas M Pajewski, Clinton B Wright, Manjula K Tamura, Greg Zaharchuk
Measurement of the ability of blood vessels to dilate and constrict, known as vascular reactivity, is often performed with breath-holding tasks that transiently raise arterial blood carbon dioxide (PaCO2) levels. However, following the proper commands for a breath-holding experiment may be difficult or impossible for many patients. In this study, we evaluated two approaches for obtaining vascular reactivity information using blood oxygenation level-dependent signal fluctuations obtained from resting-state functional magnetic resonance imaging data: physiological fluctuation regression and coefficient of variation of the resting-state functional magnetic resonance imaging signal...
September 28, 2016: Journal of Cerebral Blood Flow and Metabolism
Ashley A Zurawel, Ruth Kabeche, Sonja E DiGregorio, Lin Deng, Kartikeya M Menon, Hannah Opalko, Martin L Duennwald, James B Moseley, Surachai Supattapone
: Proteins containing polyglutamine (polyQ) regions are found in almost all eukaryotes, albeit with various frequencies. In humans, proteins such as huntingtin (Htt) with abnormally expanded polyQ regions cause neurodegenerative diseases such as Huntington's disease (HD). To study how the presence of endogenous polyQ aggregation modulates polyQ aggregation and toxicity, we expressed polyQ expanded Htt fragments (polyQ Htt) in Schizosaccharomyces pombe In stark contrast to other unicellular fungi, such as Saccharomyces cerevisiae, S...
September 27, 2016: MBio
Nicolas Winisdoerffer, Marie-Madeleine Leclercq, Aurélie Muller, Myriam Martin, Myriam Pierrat
OBJECTIVE: A rehabilitation program, with successive types of exercises, including limb laterality recognition, imagined movements and mirror therapy, can be conducted in patients with CRPS I1. This graded motor imagery program, developed by Moseley, needs patients' participation, is educative, and improves edema, pain, and functional capacities. We want to investigate whether this program would improve health-related quality of life of patients with CRPS I. MATERIAL/PATIENTS AND METHODS: All patients with upper or lower limb CRPS I are included...
September 2016: Annals of Physical and Rehabilitation Medicine
J L Moseley, M Velec, V C Kong, B Chan, A Shessel, J P Bissonnette
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Bryan J Feger, J Will Thompson, Laura G Dubois, Reddy P Kommaddi, Matthew W Foster, Rajashree Mishra, Sudha K Shenoy, Yoichiro Shibata, Yared H Kidane, M Arthur Moseley, Lisa S Carnell, Dawn E Bowles
On Earth, biological systems have evolved in response to environmental stressors, interactions dictated by physical forces that include gravity. The absence of gravity is an extreme stressor and the impact of its absence on biological systems is ill-defined. Astronauts who have spent extended time under conditions of minimal gravity (microgravity) experience an array of biological alterations, including perturbations in cardiovascular function. We hypothesized that physiological perturbations in cardiac function in microgravity may be a consequence of alterations in molecular and organellar dynamics within the cellular milieu of cardiomyocytes...
September 27, 2016: Scientific Reports
Saeid Zanganeh, Gregor Hutter, Ryan Spitler, Olga Lenkov, Morteza Mahmoudi, Aubie Shaw, Jukka Sakari Pajarinen, Hossein Nejadnik, Stuart Goodman, Michael Moseley, Lisa Marie Coussens, Heike Elisabeth Daldrup-Link
Until now, the Food and Drug Administration (FDA)-approved iron supplement ferumoxytol and other iron oxide nanoparticles have been used for treating iron deficiency, as contrast agents for magnetic resonance imaging and as drug carriers. Here, we show an intrinsic therapeutic effect of ferumoxytol on the growth of early mammary cancers, and lung cancer metastases in liver and lungs. In vitro, adenocarcinoma cells co-incubated with ferumoxytol and macrophages showed increased caspase-3 activity. Macrophages exposed to ferumoxytol displayed increased mRNA associated with pro-inflammatory Th1-type responses...
September 26, 2016: Nature Nanotechnology
Tie Yamato, Chris Maher, Bruno Saragiotto, Anne Moseley, Tammy Hoffmann, Mark Elkins, Linda Fetters
No abstract text is available yet for this article.
2016: Pediatric Physical Therapy
Aaron Brice, Donna R Whelan, Naoto Ito, Kenta Shimizu, Linda Wiltzer-Bach, Camden Y Lo, Danielle Blondel, David A Jans, Toby D M Bell, Gregory W Moseley
Although microtubules (MTs) are known to have important roles in intracellular transport of many viruses, a number of reports suggest that specific viral MT-associated proteins (MAPs) target MTs to subvert distinct MT-dependent cellular processes. The precise functional importance of these interactions and their roles in pathogenesis, however, remain largely unresolved. To assess the association with disease of the rabies virus (RABV) MAP, P3, we quantitatively compared the phenotypes of P3 from a pathogenic RABV strain, Nishigahara (Ni) and a non-pathogenic Ni-derivative strain, Ni-CE...
2016: Scientific Reports
M A Portelli, C Moseley, C E Stewart, D S Postma, P Howarth, J A Warner, J W Holloway, G H Koppelman, C Brightling, I Sayers
RATIONALE: Genetic polymorphisms in the asthma susceptibility gene, urokinase plasminogen activator receptor (uPAR/PLAUR) have been associated with lung function decline and uPAR blood levels in asthma subjects. Preliminary studies have identified uPAR elevation in asthma; however, a definitive study regarding which clinical features of asthma uPAR may be driving is currently lacking. OBJECTIVES: We aimed to comprehensively determine the uPAR expression profile in asthma and control subjects utilizing bronchial biopsies and serum, and to relate uPAR expression to asthma clinical features...
October 5, 2016: Allergy
Michelle D Audsley, David A Jans, Gregory W Moseley
Paramyxoviruses replicate in the cytoplasm with no obvious requirement to interact with the nucleus. Nevertheless, the W protein of the highly lethal bat-borne paramyxovirus Nipah virus (NiV) is known to undergo specific targeting to the nucleus, mediated by a single nuclear localisation signal (NLS) within the C-terminal domain. Here, we report for the first time that additional sites modulate nucleocytoplasmic localisation of W. We show that the N-terminal domain interacts with importin α1 and contributes to nuclear accumulation of W, indicative of a novel N-terminal NLS...
October 21, 2016: Biochemical and Biophysical Research Communications
Thomas J Weber, Eileen K Sawyer, Scott Moseley, Tatjana Odrljin, Priya S Kishnani
BACKGROUND: Hypophosphatasia (HPP) is a rare metabolic bone disease caused by loss-of-function mutation(s) in the tissue-nonspecific alkaline (TNSALP) phosphatase gene, which manifests as rickets and/or osteomalacia with systemic complications and affects patients of all ages. The burden of disease is poorly characterized in adult patients. AIMS: We assessed patient-reported burden of disease using two surveys reasonably specific for HPP symptomatology, the Hypophosphatasia Impact Patient Survey (HIPS) and the Hypophosphatasia Outcomes Study Telephone interview (HOST)...
October 2016: Metabolism: Clinical and Experimental
Esther Maas, Christopher Maher, Anne Moseley, Renske Annevelink, Jurgen Jagersma, Raymond Ostelo
BACKGROUND: The relationship between trial funding and methodological quality, the conduct and reporting of trials has been investigated in several medical disciplines, but remains unclear in musculoskeletal physical therapy trials. The aim of this study was to determine the association between funding and research team composition, sample size, quality, and journal impact factor of randomized controlled trial reports in musculoskeletal physical therapy. METHODS: A survey of 210 trial reports in musculoskeletal physical therapy, which were randomly selected from those published in 2011-2013 and indexed on the Physiotherapy Evidence Database (PEDro), is performed...
September 12, 2016: Physiotherapy Theory and Practice
Christine Tara Peterson, Joseph Lucas, Lisa St John-Williams, J Will Thompson, M Arthur Moseley, Sheila Patel, Scott N Peterson, Valencia Porter, Eric E Schadt, Paul J Mills, Rudolph E Tanzi, P Murali Doraiswamy, Deepak Chopra
The effects of integrative medicine practices such as meditation and Ayurveda on human physiology are not fully understood. The aim of this study was to identify altered metabolomic profiles following an Ayurveda-based intervention. In the experimental group, 65 healthy male and female subjects participated in a 6-day Panchakarma-based Ayurvedic intervention which included herbs, vegetarian diet, meditation, yoga, and massage. A set of 12 plasma phosphatidylcholines decreased (adjusted p < 0.01) post-intervention in the experimental (n = 65) compared to control group (n = 54) after Bonferroni correction for multiple testing; within these compounds, the phosphatidylcholine with the greatest decrease in abundance was PC ae C36:4 (delta = -0...
2016: Scientific Reports
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