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https://www.readbyqxmd.com/read/28549010/a-clinical-feasibility-trial-for-identification-of-exceptional-responders-in-whom-breast-cancer-surgery-can-be-eliminated-following-neoadjuvant-systemic-therapy
#1
Henry M Kuerer, Gaiane M Rauch, Savitri Krishnamurthy, Beatriz E Adrada, Abigail S Caudle, Sarah M DeSnyder, Dalliah M Black, Lumarie Santiago, Brian P Hobbs, Anthony Lucci, Michael Gilcrease, Rosa F Hwang, Rosalind P Candelaria, Mariana Chavez-MacGregor, Benjamin D Smith, Elsa Arribas, Tanya Moseley, Mediget Teshome, Makesha V Miggins, Vicente Valero, Kelly K Hunt, Wei T Yang
OBJECTIVE: To determine the accuracy of fine-needle aspiration (FNA) and vacuum-assisted core biopsy (VACB) in assessing the presence of residual cancer in the breast after neoadjuvant systemic therapy (NST). SUMMARY BACKGROUND DATA: Pathologic complete response (pCR) rates after NST have improved dramatically, suggesting that surgery might be avoided in some patients. Safe avoidance of surgery would require accurate confirmation of no residual invasive/in situ carcinoma...
May 25, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28545779/a-randomized-placebo-controlled-trial-of-patient-education-for-acute-low-back-pain-prevent-trial-statistical-analysis-plan
#2
REVIEW
Adrian C Traeger, Ian W Skinner, Markus Hübscher, Hopin Lee, G Lorimer Moseley, Michael K Nicholas, Nicholas Henschke, Kathryn M Refshauge, Fiona M Blyth, Chris J Main, Julia M Hush, Garry Pearce, Serigne Lo, James H McAuley
BACKGROUND: Statistical analysis plans increase the transparency of decisions made in the analysis of clinical trial results. The purpose of this paper is to detail the planned analyses for the PREVENT trial, a randomized, placebo-controlled trial of patient education for acute low back pain. RESULTS: We report the pre-specified principles, methods, and procedures to be adhered to in the main analysis of the PREVENT trial data. The primary outcome analysis will be based on Mixed Models for Repeated Measures (MMRM), which can test treatment effects at specific time points, and the assumptions of this analysis are outlined...
April 14, 2017: Brazilian Journal of Physical Therapy
https://www.readbyqxmd.com/read/28530513/a-cluster-randomized-trial-of-strategies-to-increase-uptake-amongst-young-women-invited-for-their-first-cervical-screen-the-strategic-trial
#3
H Kitchener, M Gittins, M Cruickshank, C Moseley, S Fletcher, R Albrow, A Gray, L Brabin, D Torgerson, E J Crosbie, A Sargent, C Roberts
Objectives To measure the feasibility and effectiveness of interventions to increase cervical screening uptake amongst young women. Methods A two-phase cluster randomized trial conducted in general practices in the NHS Cervical Screening Programme. In Phase 1, women in practices randomized to intervention due for their first invitation to cervical screening received a pre-invitation leaflet and, separately, access to online booking. In Phase 2, non-attenders at six months were randomized to one of: vaginal self-sample kits sent unrequested or offered; timed appointments; nurse navigator; or the choice between nurse navigator or self-sample kits...
January 1, 2017: Journal of Medical Screening
https://www.readbyqxmd.com/read/28515144/transient-activation-of-fission-yeast-ampk-is-required-for-cell-proliferation-during-osmotic-stress
#4
Katherine L Schutt, James B Moseley
The heterotrimeric kinase AMPK acts as an energy sensor to coordinate cell metabolism with environmental status in yeast through humans. Low intracellular ATP leads to AMPK activation through phosphorylation of the activation loop within the catalytic subunit. Other environmental stresses also activate AMPK, but it is unclear if cellular energy status affects AMPK activation under these conditions. Fission yeast AMPK catalytic subunit Ssp2 is phosphorylated at Thr189 by the upstream kinase Ssp1 in low glucose conditions, similar to other systems...
May 17, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28511619/daylight-photodynamic-therapy-in-scotland
#5
Helen Cordey, Ronan Valentine, Andrea Lesar, Harry Moseley, Ewan Eadie, Sally Ibbotson
Chronic sun-induced dysplastic skin changes (actinic keratoses) are extremely common in fair-skinned people in Scotland. These changes are a major cause of morbidity and may develop into skin cancer. Actinic keratoses are often extensive and pose a therapeutic challenge as field-directed treatment is required for chronic disease management. One such treatment approach is hospital-based photodynamic therapy, which is a well-established treatment in Scotland for actinic keratoses, using a photosensitiser pro-drug and red LED light irradiation...
January 1, 2017: Scottish Medical Journal
https://www.readbyqxmd.com/read/28486043/randomized-phase-ii-study-of-azacitidine-alone-or-in-combination-with-lenalidomide-or-with-vorinostat-in-higher-risk-myelodysplastic-syndromes-and-chronic-myelomonocytic-leukemia-north-american-intergroup-study-swog-s1117
#6
Mikkael A Sekeres, Megan Othus, Alan F List, Olatoyosi Odenike, Richard M Stone, Steven D Gore, Mark R Litzow, Rena Buckstein, Min Fang, Diane Roulston, Clara D Bloomfield, Anna Moseley, Aziz Nazha, Yanming Zhang, Mario R Velasco, Rakesh Gaur, Ehab Atallah, Eyal C Attar, Elina K Cook, Alyssa H Cull, Michael J Rauh, Frederick R Appelbaum, Harry P Erba
Purpose Azacitidine is standard, first-line therapy in higher-risk myelodysplastic syndromes (MDS). Whether azacitidine-based combinations with lenalidomide or vorinostat produce superior overall response rates (ORRs) to azacitidine is not known. Patients and Methods North American Intergroup Study S1117 is a phase II/III trial that randomly assigned patients with higher-risk MDS and chronic myelomonocytic leukemia (CMML) 1:1:1 to azacitidine (75 mg/m(2)/day on days 1 to 7 of a 28-day cycle); azacitidine plus lenalidomide (10 mg/day on days 1 to 21); or azacitidine plus vorinostat (300 mg twice daily on days 3 to 9)...
May 9, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28475700/biomarkers-and-surrogate-endpoints-in-drug-development-a-european-regulatory-view
#7
Kerstin Wickström, Jane Moseley
Purpose: To give a European regulatory overview of the requirements on and the use of biomarkers or surrogate endpoints in the development of drugs for ocular disease. Methods: Definitions, methods to validate new markers, and circumstances where surrogate endpoints can be appropriate are summarized. Results: The key endpoints that have been used in registration studies so far are based on visual acuity, signs, and symptoms, or on surrogate endpoints...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28475100/defensive-reflexes-in-people-with-pain-a-biomarker-of-the-need-to-protect-a-meta-analytical-systematic-review
#8
Sarah B Wallwork, Luzia Grabherr, Neil E O'Connell, Mark J Catley, G Lorimer Moseley
Upregulation of defensive reflexes such as the nociceptive flexion reflex (NFR) has been attributed to sensitisation of peripheral and spinal nociceptors and is often considered biomarkers of pain. Experimental modulation of defensive reflexes raises the possibility that they might be better conceptualised as markers of descending cognitive control. Despite strongly held views on both sides and several narrative reviews, there has been no attempt to evaluate the evidence in a systematic manner. We undertook a meta-analytical systematic review of the extant English-language literature from inception...
February 11, 2017: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/28457610/zika-virus-persistence-in-the-central-nervous-system-and-lymph-nodes-of-rhesus-monkeys
#9
Malika Aid, Peter Abbink, Rafael A Larocca, Michael Boyd, Ramya Nityanandam, Ovini Nanayakkara, Amanda J Martinot, Edward T Moseley, Eryn Blass, Erica N Borducchi, Abishek Chandrashekar, Amanda L Brinkman, Katherine Molloy, David Jetton, Lawrence J Tartaglia, Jinyan Liu, Katharine Best, Alan S Perelson, Rafael A De La Barrera, Mark G Lewis, Dan H Barouch
Zika virus (ZIKV) is associated with severe neuropathology in neonates as well as Guillain-Barré syndrome and other neurologic disorders in adults. Prolonged viral shedding has been reported in semen, suggesting the presence of anatomic viral reservoirs. Here we show that ZIKV can persist in cerebrospinal fluid (CSF) and lymph nodes (LN) of infected rhesus monkeys for weeks after virus has been cleared from peripheral blood, urine, and mucosal secretions. ZIKV-specific neutralizing antibodies correlated with rapid clearance of virus in peripheral blood but remained undetectable in CSF for the duration of the study...
May 4, 2017: Cell
https://www.readbyqxmd.com/read/28453911/validation-of-biomechanical-deformable-image-registration-in-the-abdomen-thorax-and-pelvis-in-a-commercial-radiotherapy-treatment-planning-system
#10
Michael Velec, Joanne L Moseley, Stina Svensson, Björn Hårdemark, David A Jaffray, Kristy K Brock
PURPOSE: The accuracy of deformable image registration tools can vary widely between imaging modalities and specific implementations of the same algorithms. A biomechanical model-based algorithm initially developed in-house at an academic institution was translated into a commercial radiotherapy treatment planning system and validated for multiple imaging modalities and anatomic sites. METHODS: Biomechanical deformable registration (Morfeus) is a geometry driven algorithm based on the finite element method...
April 28, 2017: Medical Physics
https://www.readbyqxmd.com/read/28451610/changes-within-clinical-practice-after-a-randomized-controlled-trial-of-knee-arthroscopy-for-osteoarthritis
#11
Nirav H Amin, Waqas Hussain, John Ryan, Shannon Morrison, Anthony Miniaci, Morgan H Jones
BACKGROUND: In 2002, Moseley et al published a randomized controlled trial (RCT) that showed no difference between knee arthroscopy and placebo for patients with osteoarthritis (OA). We wanted to assess the impact of the trial on clinical practice in the United States. PURPOSE/HYPOTHESIS: To evaluate changes in knee arthroscopy practice before and after publication of the article by Moseley et al and to assess the effect of this landmark RCT on the behavior of practicing orthopaedic surgeons...
April 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28443788/the-tidier-checklist-will-benefit-the-physiotherapy-profession
#12
Tie Yamato, Chris Maher, Bruno Saragiotto, Anne Moseley, Tammy Hoffmann, Mark Elkins, Scott Hasson
No abstract text is available yet for this article.
April 2017: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/28437216/posttraumatic-symptom-reporting-and-reported-cigarette-smoking-during-pregnancy
#13
Sara L Kornfield, Marian Moseley, Dina Appleby, Courtney L McMickens, Mary D Sammel, C Neill Epperson
INTRODUCTION: Increased prevalence of nicotine dependence among individuals suffering from posttraumatic stress disorder (PTSD) is well established. However, there are limited studies on the prevalence of smoking during pregnancy in relation to prepregnancy history of trauma exposures and active PTSD symptoms during pregnancy. Prenatal smoking has been implicated in a host of negative outcomes for mother and baby. Given maternal and fetal risk, it is critical to define predictors of continued cigarette smoking during pregnancy...
February 21, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28433236/stretch-for-the-treatment-and-prevention-of-contracture-an-abridged-republication-of-a-cochrane-systematic-review
#14
Lisa A Harvey, Owen M Katalinic, Robert D Herbert, Anne M Moseley, Natasha A Lannin, Karl Schurr
QUESTION: Is stretch effective for the treatment and prevention of contractures in people with neurological and non-neurological conditions? DESIGN: A Cochrane Systematic Review with meta-analyses of randomised trials. PARTICIPANTS: People with or at risk of contractures. INTERVENTION: Trials were considered for inclusion if they compared stretch to no stretch, or stretch plus co-intervention to co-intervention only...
April 2017: Journal of Physiotherapy
https://www.readbyqxmd.com/read/28423171/identification-of-patients-with-documented-pathologic-complete-response-in-the-breast-after-neoadjuvant-chemotherapy-for-omission-of-axillary-surgery
#15
Audree B Tadros, Wei T Yang, Savitri Krishnamurthy, Gaiane M Rauch, Benjamin D Smith, Vicente Valero, Dalliah M Black, Anthony Lucci, Abigail S Caudle, Sarah M DeSnyder, Mediget Teshome, Carlos H Barcenas, Makesha Miggins, Beatriz E Adrada, Tanya Moseley, Rosa F Hwang, Kelly K Hunt, Henry M Kuerer
Importance: A pathologic complete response (pCR; no invasive or in situ cancer) occurs in 40% to 50% of patients with HER2-positive (HER2+) and triple-negative (TN) breast cancer. The need for surgery if percutaneous biopsy of the breast after neoadjuvant chemotherapy (NCT) indicates pCR in the breast (hereinafter referred to as breast pCR) has been questioned, and appropriate management of the axilla in such patients is unknown. Objective: To identify patients among exceptional responders to NCT with a low risk for axillary metastases when breast pCR is documented who may be eligible for an omission of surgery clinical trial design...
April 19, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28422409/validation-of-the-japanese-version-of-the-fremantle-back-awareness-questionnaire-in-patients-with-low-back-pain
#16
Tomokiko Nishigami, Akira Mibu, Katsuyoshi Tanaka, Yuh Yamashita, Michele Eisemann Shimizu, Bennedict Wand, Mark J Catley, Tasha R Stanton, G Lorimer Moseley
BACKGROUND: There is a growing interest in the role of disturbed body perception in people with persistent pain problems such as chronic low back pain (CLBP). A questionnaire, the Fremantle Back Awareness Questionnaire (FreBAQ), was recently developed as a simple and quick way of assessing disturbed perceptual awareness of the back in people with CLBP and appears to have acceptable psychometric properties. The aim of the present study was to develop a Japanese version of the FreBAQ (FreBAQ-J) and evaluate its psychometric properties in a sample of Japanese people with low back pain (LBP)...
April 18, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/28390794/effect-of-mammography-on-marker-clip-migration-after-stereotactic-guided-core-needle-breast-biopsy
#17
Huong T Le-Petross, Kenneth R Hess, John D Knudtson, Deanna L Lane, Tanya W Moseley, William R Geiser, Gary J Whitman
OBJECTIVE: To determine whether the type of projection used-same as or orthogonal to the projection used during a stereotactic-guided core needle biopsy procedure-to obtain the first view on a 2-view postbiopsy mammogram affects biopsy marker clip migration. PATIENTS AND METHODS: We prospectively recruited women scheduled to undergo stereotactic-guided core needle breast biopsy with marker clip deployment and categorized the women randomly into one of the following 2 groups: first view on the postbiopsy mammogram obtained in the same projection as that used during the biopsy procedure (group 1), or first view on the postbiopsy mammogram obtained orthogonally to the projection used during the biopsy procedure (group 2)...
February 16, 2017: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/28385510/classical-conditioning-differences-associated-with-chronic-pain-a-systematic-review
#18
REVIEW
Daniel S Harvie, G Lorimer Moseley, Susan L Hillier, Ann Meulders
Prominent clinical models of chronic pain propose a fundamental role of classical conditioning in the development of pain-related disability. If classical conditioning is key to this process, then people with chronic pain may show a different response to pain-related conditioned stimuli than healthy control subjects. We set out to determine whether this is the case by undertaking a comprehensive and systematic review of the literature. To identify studies comparing classical conditioning between people with chronic pain and healthy control subjects, the databases MEDLINE, PsychINFO, PsychARTICLES, Scopus, and CINAHL were searched using key words and medical subject headings consistent with 'classical conditioning' and 'pain...
April 4, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28383710/the-mobile-study-a-phase-iia-enriched-enrollment-randomized-withdrawal-trial-to-assess-the-analgesic-efficacy-and-safety-of-asp8477-a-fatty-acid-amide-hydrolase-inhibitor-in-patients-with-peripheral-neuropathic-pain
#19
Daniel Bradford, Anjali Stirling, Etienne Ernault, Maggie Liosatos, Katherine Tracy, Jennifer Moseley, Paul Blahunka, Mike D Smith
Objective.:  To evaluate the analgesic efficacy and safety of ASP8477 in patients with peripheral neuropathic pain (PNP). Design.:  Enriched enrollment randomized withdrawal. Setting.:  Centers in Poland (four), Czech Republic (six), and the United Kingdom (two). Subjects.:  Patients aged 18 years or older with PNP resulting from painful diabetic peripheral neuropathy or postherpetic neuralgia. Methods...
April 5, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28382306/apolipoprotein-e-mimetic-peptide-cn-105-improves-outcomes-in-ischemic-stroke
#20
Tian Ming Tu, Brad J Kolls, Erik J Soderblom, Viviana Cantillana, Paul Durham Ferrell, M Arthur Moseley, Haichen Wang, Hana N Dawson, Daniel T Laskowitz
OBJECTIVE: At present, the absence of a pharmacological neuroprotectant represents an important unmet clinical need in the treatment of ischemic and traumatic brain injury. Recent evidence suggests that administration of apolipoprotein E mimetic therapies represent a viable therapeutic strategy in this setting. We investigate the neuroprotective and anti-inflammatory properties of the apolipoprotein E mimetic pentapeptide, CN-105, in a microglial cell line and murine model of ischemic stroke...
April 2017: Annals of Clinical and Translational Neurology
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