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https://www.readbyqxmd.com/read/28100231/can-screening-instruments-accurately-determine-poor-outcome-risk-in-adults-with-recent-onset-low-back-pain-a-systematic-review-and-meta-analysis
#1
Emma L Karran, James H McAuley, Adrian C Traeger, Susan L Hillier, Luzia Grabherr, Leslie N Russek, G Lorimer Moseley
BACKGROUND: Delivering efficient and effective healthcare is crucial for a condition as burdensome as low back pain (LBP). Stratified care strategies may be worthwhile, but rely on early and accurate patient screening using a valid and reliable instrument. The purpose of this study was to evaluate the performance of LBP screening instruments for determining risk of poor outcome in adults with LBP of less than 3 months duration. METHODS: Medline, Embase, CINAHL, PsycINFO, PEDro, Web of Science, SciVerse SCOPUS, and Cochrane Central Register of Controlled Trials were searched from June 2014 to March 2016...
January 19, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28097307/association-of-periodic-discharges-with-reduced-brain-tissue-oxygenation-no-longer-straddling-the-fence
#2
Brian D Moseley
No abstract text is available yet for this article.
January 9, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28087845/waking-eeg-cortical-markers-of-chronic-pain-and-sleepiness
#3
Danny Camfferman, G Lorimer Moseley, Kevin Gertz, Mark W Pettet, Mark P Jensen
OBJECTIVE: Spectral power analyses of EEG recordings are reported to distinguish the cortical activity of individuals with chronic pain from those of controls. Further study of these spectral patterns may provide a greater understanding of the processes associated with chronic pain, in addition to providing potential biometric markers of chronic pain for use in both clinical and research settings. However, sleep deprived groups have demonstrated similar characteristics in their spectral power characteristics, particularly in alpha bandwidth power activity...
January 13, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28081134/pain-a-statistical-account
#4
REVIEW
Abby Tabor, Michael A Thacker, G Lorimer Moseley, Konrad P Körding
Perception is seen as a process that utilises partial and noisy information to construct a coherent understanding of the world. Here we argue that the experience of pain is no different; it is based on incomplete, multimodal information, which is used to estimate potential bodily threat. We outline a Bayesian inference model, incorporating the key components of cue combination, causal inference, and temporal integration, which highlights the statistical problems in everyday perception. It is from this platform that we are able to review the pain literature, providing evidence from experimental, acute, and persistent phenomena to demonstrate the advantages of adopting a statistical account in pain...
January 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28064524/an-embedded-randomised-controlled-trial-of-a-teaser-campaign-to-optimise-recruitment-in-primary-care
#5
Hopin Lee, Markus Hübscher, G Lorimer Moseley, Steven J Kamper, Adrian C Traeger, Ian W Skinner, Christopher M Williams, James H McAuley
BACKGROUND: Marketing communication and brand identity is a fundamental principle of advertising and end-user engagement. Health researchers have begun to apply this principle to trial recruitment in primary care. The aim of this study was to evaluate whether a Teaser Campaign using a series of postcards in advance of a conventional mail-out increases the number of primary care clinics that engage with a clinical trial. METHODS: Embedded randomised recruitment trial across primary care clinics (general practitioners and physiotherapists) in the Sydney metropolitan area...
January 1, 2017: Clinical Trials: Journal of the Society for Clinical Trials
https://www.readbyqxmd.com/read/28058032/understanding-patient-perspectives-on-management-of-their-chronic-pain-online-survey-protocol
#6
Manasi Gaikwad, Simon Vanlint, G Lorimer Moseley, Murthy N Mittinty, Nigel Stocks
BACKGROUND: It is widely recognized that both doctors and patients report discontent regarding pain management provided and received. The impact of chronic pain on an individual's life resonates beyond physical and mental suffering; equal or at times even greater impact is observed on an individual's personal relationships, ability to work, and social interactions. The degree of these effects in each individual varies, mainly because of differences in biological factors, social environment, past experiences, support, and belief systems...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28056216/nuclear-localization-and-secretion-competence-is-conserved-amongst-henipavirus-matrix-proteins
#7
Elisabeth C McLinton, Kylie M Wagstaff, Alexander Lee, Gregory W Moseley, Glenn A Marsh, Lin-Fa Wang, David A Jans, Kim G Lieu, Hans Netter
Viruses of the genus Henipavirus of the family Paramyxoviridae are zoonotic pathogens, which have emerged in South East Asia, Australia and Africa. Nipah virus (NiV) and Hendra virus (HeV) are highly virulent pathogens transmitted from bats to animals and humans, whilst the henipavirus Cedar virus (CedV) seems to be non-pathogenic in infection studies. The full replication cycle of the Paramyxoviridae occurs in the host cell's cytoplasm where viral assembly is orchestrated by the matrix (M) protein. Unexpectedly, the NiV-M protein traffics through the nucleus as an essential step to engage the plasma membrane in preparation for viral budding/release...
January 5, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/27993360/the-quality-of-clinical-practice-guidelines-for-chronic-respiratory-diseases-and-the-reliability-of-the-agree-ii-an-observational-study
#8
Juliana Souza Uzeloto, Anne M Moseley, Mark R Elkins, Marcia Rodrigues Franco, Rafael Zambelli Pinto, Ana Paula Coelho Figueira Freire, Ercy Mara Cipulo Ramos
OBJECTIVES: To survey the quality of evidence-based clinical practice guidelines for chronic respiratory diseases relevant to physiotherapy practice using the Appraisal of Guidelines for Research and Evaluation version II instrument (AGREE II) and to evaluate the inter-rater reliability of AGREE II. DESIGN: Observational survey. PROCEDURES: Guidelines indexed in the Physiotherapy Evidence Database (PEDro) on chronic respiratory diseases were evaluated by four assessors using AGREE II...
November 15, 2016: Physiotherapy
https://www.readbyqxmd.com/read/27979465/open-access-phone-triage-for-veterans-with-suspected-malignant-pleural-mesothelioma
#9
Charles Jeff Siegert, Piero Marco Fisichella, Jennifer M Moseley, Melina Shoni, Abraham Lebenthal
BACKGROUND: Phone triaging patients with suspected malignant pleural mesothelioma (MPM) within the Veterans Healthcare Administration (VHA) system offers a model for rapid, expert guided evaluation for patients with rare and treatable diseases within a national integrated healthcare system. To assess feasibility of national open access telephone triage using evidence-based treatment recommendations for patients with MPM, measure timelines of the triage and referral process and record the impact on "intent to treat" for patients using our service...
January 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/27973753/vagal-nerve-stimulation-modifies-neuronal-activity-and-the-proteome-of-excitatory-synapses-of-amygdala-piriform-cortex
#10
Georgia M Alexander, Yang Zhong Huang, Erik J Soderblom, Xiao-Ping He, Arthur M Moseley, James O McNamara
Vagal Nerve Stimulation (VNS) Therapy(®) is a United States Food and Drug Administration (FDA) approved neurotherapeutic for medically refractory partial epilepsy and treatment-resistant depression. The molecular mechanisms underlying its beneficial effects are unclear. We hypothesized that one mechanism involves neuronal activity-dependent modifications of central nervous system excitatory synapses. To begin to test this hypothesis, we asked whether VNS modifies the activity of neurons in amygdala and hippocampus...
December 14, 2016: Journal of Neurochemistry
https://www.readbyqxmd.com/read/27966365/proteomic-analysis-of-primary-human-airway-epithelial-cells-exposed-to-the-respiratory-toxicant-diacetyl
#11
Matthew W Foster, William M Gwinn, Francine L Kelly, David M Brass, Ashlee M Valente, M Arthur Moseley, J Will Thompson, Daniel L Morgan, Scott M Palmer
Occupational exposures to the diketone flavoring agent, diacetyl, have been associated with bronchiolitis obliterans, a rare condition of airway fibrosis. Model studies in rodents have suggested that the airway epithelium is a major site of diacetyl toxicity, but the effects of diacetyl exposure upon the human airway epithelium are poorly characterized. Here we performed quantitative LC-MS/MS-based proteomics to study the effects of repeated diacetyl vapor exposures on 3D organotypic cultures of human primary tracheobronchial epithelial cells...
January 9, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/27964941/testing-continuum-models-of-psychosis-no-reduction-in-source-monitoring-ability-in-healthy-individuals-prone-to-auditory-hallucinations
#12
Jane R Garrison, Peter Moseley, Ben Alderson-Day, David Smailes, Charles Fernyhough, Jon S Simons
People with schizophrenia who hallucinate show impairments in reality monitoring (the ability to distinguish internally generated information from information obtained from external sources) compared to non-hallucinating patients and healthy individuals. While this may be explained at least in part by an increased externalizing bias, it remains unclear whether this impairment is specific to reality monitoring, or whether it also reflects a general deficit in the monitoring of self-generated information (internal source monitoring)...
November 22, 2016: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/27939089/the-resolve-trial-for-people-with-chronic-low-back-pain-protocol-for-a-randomised-clinical-trial
#13
Matthew K Bagg, Markus Hübscher, Martin Rabey, Benedict M Wand, Edel O'Hagan, G Lorimer Moseley, Tasha R Stanton, Chris G Maher, Stephen Goodall, Sopany Saing, Neil E O'Connell, Hannu Luomajoki, James H McAuley
INTRODUCTION: Low back pain is the leading worldwide cause of disability, and results in significant personal hardship. Most available treatments, when tested in high-quality randomised, controlled trials, achieve only modest improvements in pain, at best. Recently, treatments that target central nervous system function have been developed and tested in small studies. Combining treatments that target central nervous system function with traditional treatments directed towards functioning of the back is a promising approach that has yet to be tested in adequately powered, prospectively registered, clinical trials...
January 2017: Journal of Physiotherapy
https://www.readbyqxmd.com/read/27929726/treatment-of-amblyopia-using-personalized-dosing-strategies-statistical-modelling-and-clinical-implementation
#14
Michael P Wallace, Catherine E Stewart, Merrick J Moseley, David A Stephens, Alistair R Fielder
PURPOSE: To generate a statistical model for personalizing a patient's occlusion therapy regimen. METHODS: Statistical modelling was undertaken on a combined data set of the Monitored Occlusion Treatment of Amblyopia Study (MOTAS) and the Randomized Occlusion Treatment of Amblyopia Study (ROTAS). This exercise permits the calculation of future patients' total effective dose (TED)-that predicted to achieve their best attainable visual acuity. Daily patching regimens (hours/day) can be calculated from the TED...
December 2016: Strabismus
https://www.readbyqxmd.com/read/27913820/cerebral-blood-flow-transit-time-and-apparent-diffusion-coefficient-in-moyamoya-disease-before-and-after-acetazolamide
#15
Christian Federau, Soren Christensen, Zungho Zun, Sun-Won Park, Wendy Ni, Michael Moseley, Greg Zaharchuk
INTRODUCTION: The goal of this study was to assess the changes in arterial spin labeling (ASL) cerebral blood flow (CBF) and arterial transit time (ATT), and in apparent diffusion coefficient (ADC), before and after an acetazolamide challenge in moyamoya patients, as function of arterial stenosis severity. METHODS: Pre-operative patients diagnosed with moyamoya disease who could undergo MRI at 3.0T were recruited for this study. A multi-delay pseudo-continuous ASL and a diffusion-weighted sequence were acquired before and 15 min after acetazolamide injection...
December 2, 2016: Neuroradiology
https://www.readbyqxmd.com/read/27904230/the-tidier-checklist-will-benefit-the-physiotherapy-profession
#16
EDITORIAL
Tie Yamato, Chris Maher, Bruno Saragiotto, Anne Moseley, Tammy Hoffmann, Mark Elkins, Dina Brooks
No abstract text is available yet for this article.
2016: Physiotherapy Canada. Physiothérapie Canada
https://www.readbyqxmd.com/read/27899009/concise-xanthine-synthesis-via-a-double-amidination-reaction-of-a-6-chlorouracil-with-amidines-using-base-metal-catalysis
#17
Bénédicte Morel, Philippe Franck, Johan Bidange, Sergey Sergeyev, Dan Smith, Jonathan Moseley, Bert Uw Maes
A novel and concise route towards xanthines via a double amidination reaction is described; consecutive intermolecular C-Cl and intramolecular oxidative C-H amidination. N-uracil amidines are obtained via SNAE on a 6-chlorouracil with amidines. Direct Cu-catalyzed oxidative C-H amidination on these N-uracil amidines yields polysubstituted xanthines. Sustainable oxidants, di-tert-butyl peroxide or oxygen, can be used in this oxidase type reaction. The protocol allows for the introduction of N1, N3, N7 and C8 substituents during the xanthine scaffold construction, thus avoiding post-functionalization steps...
November 29, 2016: ChemSusChem
https://www.readbyqxmd.com/read/27886941/management-of-musculoskeletal-pain-in-a-compensable-environment-implementation-of-helpful-and-unhelpful-models-of-care-in-supporting-recovery-and-return-to-work
#18
REVIEW
Darren Beales, Kal Fried, Michael Nicholas, Fiona Blyth, Damien Finniss, G Lorimer Moseley
Models of Care (MoCs) for injured workers in the compensation environment recommend adoption of biopsychosocial management approaches. Still, widespread dominance of biomedical constructs at the system, organisational and individual levels of the compensation system prevails, contributing to suboptimal management practices and outcomes for injured workers. Efforts to implement contemporary MoCs in the compensation environment show some promise in improving outcomes. Areas of promise at the organisational level, particularly in the workplace, and at the system level are discussed...
June 2016: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/27886561/the-stop-bang-questionnaire-improves-the-detection-of-epilepsy-patients-at-risk-for-obstructive-sleep-apnea
#19
Anumeha Sharma, Jennifer Molano, Brian D Moseley
Patients with epilepsy and obstructive sleep apnea (OSA) are at risk for worsened seizure control and quality of life. We performed a quality improvement project, evaluating for improvements in the screening of OSA in epilepsy patients using the STOP-BANG questionnaire. The electronic medical records of patients seen in our epilepsy clinic were screened for 4 months prior to the intervention. We subsequently implemented the STOP-BANG questionnaire for 3 months. Only 22/664 patients (3.3%) had their sleeping habits explored during the pre-intervention period; 11 (1...
November 18, 2016: Epilepsy Research
https://www.readbyqxmd.com/read/27884861/diagnostic-accuracy-of-the-ottawa-ankle-and-midfoot-rules-a-systematic-review-with-meta-analysis
#20
Paula R Beckenkamp, Chung-Wei Christine Lin, Petra Macaskill, Zoe A Michaleff, Chris G Maher, Anne M Moseley
OBJECTIVE: To review the diagnostic accuracy of the Ottawa Ankle and Midfoot Rules and explore if clinical features and/or methodological quality of the study influence diagnostic accuracy estimates. DESIGN: Systematic review with meta-analysis. DATA SOURCES: MEDLINE, EMBASE, CINAHL, SPORTDiscus and Cochrane Library. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Primary diagnostic studies reporting the accuracy of the Rules in people with ankle and/or midfoot injury were retrieved...
November 24, 2016: British Journal of Sports Medicine
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