keyword
MENU ▼
Read by QxMD icon Read
search

Moseley

keyword
https://www.readbyqxmd.com/read/29136387/randomized-multicenter-placebo-controlled-clinical-trial-of-duloxetine-versus-placebo-for-aromatase-inhibitor-associated-arthralgias-in-early-stage-breast-cancer-swog-s1202
#1
N Lynn Henry, Joseph M Unger, Anne F Schott, Louis Fehrenbacher, Patrick J Flynn, Debra M Prow, Carl W Sharer, Gary V Burton, Charles S Kuzma, Anna Moseley, Danika L Lew, Michael J Fisch, Carol M Moinpour, Dawn L Hershman, James L Wade
Purpose Adherence to aromatase inhibitor (AI) therapy for early-stage breast cancer is limited by AI-associated musculoskeletal symptoms (AIMSS). Duloxetine is US Food and Drug Administration approved for treatment of multiple chronic pain disorders. We hypothesized that treatment of AIMSS with duloxetine would improve average joint pain compared with placebo. Methods This randomized, double-blind, phase III trial included AI-treated postmenopausal women with early-stage breast cancer and who had average joint pain score of ≥ 4 out of 10 that developed or worsened since AI therapy initiation...
November 14, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29133620/evaluation-of-cdk12-protein-expression-as-a-potential-novel-biomarker-for-dna-damage-response-targeted-therapies-in-breast-cancer
#2
Kalnisha Naidoo, Patty T Wai, Sarah L Maguire, Frances Daley, Syed Haider, Divya Kriplani, James Campbell, Hasan Mirza, Anita Grigoriadis, Andrew Tutt, Paul M Moseley, Tarek M A Abdel-Fatah, Stephen Yt Chan, Srinivasan Madhusudan, Emad A Rakha, Ian O Ellis, Christopher J Lord, Yinyin Yuan, Andrew R Green, Rachael Natrajan
Disruption of Cyclin Dependent Kinase 12 (CDK12) is known to lead to defects in DNA repair and sensitivity to platinum salts and poly(ADP-ribose) polymerase 1/2 inhibitors. However, CDK12 has also been proposed as an oncogene in breast cancer. We therefore aimed to assess the frequency and distribution of CDK12 protein expression by immunohistochemistry (IHC) in independent cohorts of breast cancer and correlate this with outcome and genomic status. We found that 21% of primary unselected breast cancers were CDK12 high, and 10...
November 13, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29103550/causal-mechanisms-in-the-clinical-course-and-treatment-of-back-pain
#3
REVIEW
H Lee, G Mansell, J H McAuley, S J Kamper, M Hübscher, G L Moseley, L Wolfenden, R K Hodder, C M Williams
In recent years, there has been increasing interest in studying causal mechanisms in the development and treatment of back pain. The aim of this article is to provide an overview of our current understanding of causal mechanisms in the field. In the first section, we introduce key concepts and terminology. In the second section, we provide a brief synopsis of systematic reviews of mechanism studies relevant to the clinical course and treatment of back pain. In the third section, we reflect on the findings of our review to explain how understanding causal mechanisms can inform clinical practice and the implementation of best practice...
December 2016: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/29095651/factors-associated-with-vitamin-d-testing-deficiency-intake-and-supplementation-in-patients-with-chronic-pain
#4
Manasi Gaikwad, Simon Vanlint, G Lorimer Moseley, Murthy N Mittinty, Nigel Stocks
Vitamin D deficiency is a public health issue, with reports of six- to twenty-five-fold rise in vitamin D testing. Vitamin D deficiency has been linked to many chronic diseases such as diabetes mellitus, cardiovascular disease, depression, and chronic pain. Identifying factors associated with risk of deficiency in individuals with chronic pain will help minimize time and cost. This study aims to examine the factors associated with vitamin D testing, intake, and physician-advised supplementation in individuals with chronic pain...
November 2, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29092211/terahertz-scattering-and-water-absorption-for-porosimetry
#5
Barmak Heshmat, Gordon Moseley Andrews, Oscar A Naranjo-Montoya, Enrique Castro-Camus, Davide Ciceri, Albert Redo Sanchez, Antoine Allanore, Anthony A Kmetz, Shannon L Eichmann, Martin E Poitzsch, Ramesh Raskar
We use terahertz transmission through limestone sedimentary rock samples to assess the macro and micro porosity. We exploit the notable water absorption in the terahertz spectrum to interact with the pores that are two orders of magnitude smaller (<1μm) than the terahertz wavelength. Terahertz water sensitivity provides us with the dehydration profile of the rock samples. The results show that there is a linear correlation between such a profile and the ratio of micro to macro porosity of the rock. Furthermore, this study estimates the absolute value of total porosity based on optical diffusion theory...
October 30, 2017: Optics Express
https://www.readbyqxmd.com/read/29041204/dual-focus-polarisation-splitting-lens
#6
Paul Moseley, Giorgio Savini, Jin Zhang, Peter Ade
We have successfully designed and measured a unique polarisation splitting lens which focuses the orthogonal linear polarisations side-by-side in the lens focal plane. This concept can find application in situations where there is limited space for the beam splitters and focusing optics that are required for incoherent detectors.
October 16, 2017: Optics Express
https://www.readbyqxmd.com/read/29039849/targeted-metabolomics-and-medication-classification-data-from-participants-in-the-adni1-cohort
#7
Lisa St John-Williams, Colette Blach, Jon B Toledo, Daniel M Rotroff, Sungeun Kim, Kristaps Klavins, Rebecca Baillie, Xianlin Han, Siamak Mahmoudiandehkordi, John Jack, Tyler J Massaro, Joseph E Lucas, Gregory Louie, Alison A Motsinger-Reif, Shannon L Risacher, Andrew J Saykin, Gabi Kastenmüller, Matthias Arnold, Therese Koal, M Arthur Moseley, Lara M Mangravite, Mette A Peters, Jessica D Tenenbaum, J Will Thompson, Rima Kaddurah-Daouk
Alzheimer's disease (AD) is the most common neurodegenerative disease presenting major health and economic challenges that continue to grow. Mechanisms of disease are poorly understood but significant data point to metabolic defects that might contribute to disease pathogenesis. The Alzheimer Disease Metabolomics Consortium (ADMC) in partnership with Alzheimer Disease Neuroimaging Initiative (ADNI) is creating a comprehensive biochemical database for AD. Using targeted and non- targeted metabolomics and lipidomics platforms we are mapping metabolic pathway and network failures across the trajectory of disease...
October 17, 2017: Scientific Data
https://www.readbyqxmd.com/read/29038138/letter-re-efficacy-and-safety-of-brivaracetam-for-partial-onset-seizures-in-3-pooled-clinical-studies
#8
Pavel Klein, Selim R Benbadis, Anyzeila Diaz, Brian D Moseley, Elinor Ben-Menachem
No abstract text is available yet for this article.
October 17, 2017: Neurology
https://www.readbyqxmd.com/read/29032705/a-mobile-application-for-monitoring-and-management-of-depressed-mood-in-a-vulnerable-pregnant-population
#9
Liisa Hantsoo, Stephanie Criniti, Annum Khan, Marian Moseley, Naomi Kincler, Laura J Faherty, C Neill Epperson, Ian M Bennett
OBJECTIVE: This study tested whether a mood tracking and alert (MTA) mobile application (app) improved mental health care delivery in a high-risk obstetric population. METHODS: Pregnant women with depressive symptomatology at <32 weeks gestation were followed for eight weeks after randomization to a control patient portal (PP) app alone or with the MTA app. The MTA app monitored activity, assessed mood, and alerted obstetric providers of signs of worsening mood...
October 16, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/29031589/implicit-evaluations-and-physiological-threat-responses-in-people-with-persistent-low-back-pain-and-fear-of-bending
#10
J P Caneiro, Peter O'Sullivan, Anne Smith, G Lorimer Moseley, Ottmar V Lipp
BACKGROUND AND AIMS: Pain and protective behaviour are dependent on implicit evaluations of danger to the body. However, current assessment of perceived danger relies on self-report, on information of which the person is aware and willing to disclose. To overcome this limitation, attempts have been made to investigate implicit evaluation of movement-related threatening images in people with persistent low back pain (PLBP) and pain-related fear. Lack of specificity of the sample and stimuli limited those explorations...
October 11, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/28986437/harmonizing-lipidomics-nist-interlaboratory-comparison-exercise-for-lipidomics-using-standard-reference-material-1950-metabolites-in-frozen-human-plasma
#11
John A Bowden, Alan Heckert, Candice Z Ulmer, Christina M Jones, Jeremy P Koelmel, Laila Abdullah, Linda Ahonen, Yazen Alnouti, Aaron Armando, John M Asara, Takeshi Bamba, John R Barr, Jonas Bergquist, Christoph H Borchers, Joost Brandsma, Susanne B Breitkopf, Tomas Cajka, Amaury Cazenave-Gassiot, Antonio Checa, Michelle A Cinel, Romain A Colas, Serge Cremers, Edward A Dennis, James E Evans, Alexander Fauland, Oliver Fiehn, Michael S Gardner, Timothy J Garrett, Katherine H Gotlinger, Jun Han, Yingying Huang, Aveline Huipeng Neo, Tuulia Hyotylainen, Yoshihiro Izumi, Hongfeng Jiang, Houli Jiang, Jiang Jiang, Maureen Kachman, Reiko Kiyonami, Kristaps Klavins, Christian Klose, Harald C Kofeler, Johan Kolmert, Therese Koal, Grielof Koster, Zsuzsanna Kuklenyik, Irwin J Kurland, Michael Leadley, Karen Lin, Krishna Rao Maddipati, Danielle McDougall, Peter J Meikle, Natalie A Mellett, Cian Monnin, M Arthur Moseley, Renu Nandakumar, Matej Oresic, Rainey E Patterson, David Peake, Jason S Pierce, Martin Post, Anthony D Postle, Rebecca Pugh, Yunping Qui, Oswald Quehenberger, Parsram Ramrup, Jon Rees, Barbara Rembiesa, Denis Reynaud, Mary R Roth, Susanne Sales, Kai Schuhmann, Michal Laniado Schwartzman, Charles N Serhan, Andrej Shevchenko, Stephen E Somerville, Lisa St John-Williams, Michal A Surma, Hiroaki Takeda, Rhishikesh Thakare, J Will Thompson, Federico Torta, Alexander Triebl, Martin Trotzmuller, S J Kumari Ubhayasekera, Dajana Vuckovic, Jacquelyn M Weir, Ruth Welti, Markus R Wenk, Craig E Wheelock, Libin Yao, Min Yuan, Xueqing Heather Zhao, Senlin Zhou
As the lipidomics field continues to advance, self-evaluation within the community is critical. Here, we performed an interlaboratory comparison exercise for lipidomics using Standard Reference Material (SRM) 1950 Metabolites in Frozen Human Plasma, a commercially available reference material. The interlaboratory study comprised 31 diverse laboratories, with each lab using a different lipidomics workflow. A total of 1527 unique lipids were measured across all laboratories, and consensus location estimates and associated uncertainties were determined for 339 of these lipids measured at the sum composition level by five or more participating laboratories...
October 6, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28983274/ranking-the-leading-risk-factors-for-sudden-unexpected-death-in-epilepsy
#12
REVIEW
Christopher M DeGiorgio, Daniela Markovic, Rajarshi Mazumder, Brian D Moseley
BACKGROUND: Sudden unexpected death in epilepsy (SUDEP) is rare in well-controlled epilepsy. However, SUDEP is a common cause of death in drug-resistant epilepsy. Over the last 30 years, multiple cohort and population studies have identified clinical risk factors associated with an increased risk for SUDEP. OBJECTIVE: To identify and rank the leading SUDEP risk factors from major cohort and population-based studies. The incidence of SUDEP is also evaluated in special clinical situations, including antiepileptic drug treatment, epilepsy surgery, devices, and assignment to placebo in clinical trials...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28974650/inhibition-of-the-oncogenic-fusion-protein-ews-fli1-causes-g2-m-cell-cycle-arrest-and-enhanced-vincristine-sensitivity-in-ewing-s-sarcoma
#13
Stefan K Zöllner, Saravana P Selvanathan, Garrett T Graham, Ryan M T Commins, Sung Hyeok Hong, Eric Moseley, Sydney Parks, Jessica N Haladyna, Hayriye V Erkizan, Uta Dirksen, Michael D Hogarty, Aykut Üren, Jeffrey A Toretsky
Ewing's sarcoma (ES) is a rare and highly malignant cancer that grows in the bones or surrounding tissues mostly affecting adolescents and young adults. A chimeric fusion between the RNA binding protein EWS and the ETS family transcription factor FLI1 (EWS-FLI1), which is generated from a chromosomal translocation, is implicated in driving most ES cases by modulation of transcription and alternative splicing. The small-molecule YK-4-279 inhibits EWS-FLI1 function and induces apoptosis in ES cells. We aimed to identify both the underlying mechanism of the drug and potential combination therapies that might enhance its antitumor activity...
October 3, 2017: Science Signaling
https://www.readbyqxmd.com/read/28962828/quality-of-musculoskeletal-trials-methodological-quality-and-statistical-reporting-of-physical-therapy-randomized-controlled-trials-relevant-to-musculoskeletal-conditions
#14
Gabrielle Zoldan Gonzalez, Anne M Moseley, Christopher G Maher, Dafne Port Nascimento, Lucíola da Cunha Menezes Costa, Leonardo Oliveira Pena Costa
OBJECTIVES: To investigate the methodological quality and statistical reporting of reports of trials indexed on the Physiotherapy Evidence Database (PEDro) classified in the musculoskeletal subdiscipline, and to analyse the characteristics of the trials that can predict trial report quality. DESIGN: Cross-sectional study based on a collection of randomised controlled. We randomly selected 19% of trial reports coded as "musculoskeletal" from the PEDro database. Methodological quality was assessed using the PEDro scale...
September 26, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28942748/nutritional-psychiatry-the-present-state-of-the-evidence
#15
Wolfgang Marx, Genevieve Moseley, Michael Berk, Felice Jacka
Mental illness, including depression, anxiety and bipolar disorder, accounts for a significant proportion of global disability and poses a substantial social, economic and heath burden. Treatment is presently dominated by pharmacotherapy, such as antidepressants, and psychotherapy, such as cognitive behavioural therapy; however, such treatments avert less than half of the disease burden, suggesting that additional strategies are needed to prevent and treat mental disorders. There are now consistent mechanistic, observational and interventional data to suggest diet quality may be a modifiable risk factor for mental illness...
November 2017: Proceedings of the Nutrition Society
https://www.readbyqxmd.com/read/28927671/quality-language-subdiscipline-and-promotion-were-associated-with-article-accesses-on-physiotherapy-evidence-database-pedro
#16
Tiê P Yamato, Mohit Arora, Matthew L Stevens, Mark R Elkins, Anne M Moseley
OBJECTIVE: To quantify the relationship between the number of times articles are accessed on the Physiotherapy Evidence Database (PEDro) and the article characteristics. A secondary aim was to examine the relationship between accesses and the number of citations of articles. METHOD: The study was conducted to derive prediction models for the number of accesses of articles indexed on PEDro from factors that may influence an article's accesses. All articles available on PEDro from August 2014 to January 2015 were included...
August 12, 2017: Physiotherapy
https://www.readbyqxmd.com/read/28924043/dynamic-regulation-of-cdr1-localization-and-phosphorylation-during-osmotic-stress
#17
Hannah E Opalko, James B Moseley
Environmental conditions modulate cell cycle progression in many cell types. A key component of the eukaryotic cell cycle is the protein kinase Wee1, which inhibits the cyclin-dependent kinase Cdk1 in yeast through human cells. In the fission yeast Schizosaccharomyces pombe, the protein kinase Cdr1 is a mitotic inducer that promotes mitotic entry by phosphorylating and inhibiting Wee1. Cdr1 and Wee1 both localize to punctate structures termed nodes on the medial cortex, but it has been unknown if node localization can be altered by physiological signals...
September 18, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28901143/scanning-quadrupole-data-independent-acquisition-part-a-qualitative-and-quantitative-characterization
#18
M Arthur Moseley, Christopher J Hughes, Praveen R Juvvadi, Erik J Soderblom, Sarah Lennon, Simon R Perkins, J Will Thompson, William J Steinbach, Scott J Geromanos, Jason Wildgoose, James I Langridge, Keith Richardson, Johannes P C Vissers
A novel data independent acquisition (DIA) method incorporating a scanning quadrupole in front of a collision cell and orthogonal acceleration time-of-flight mass analyzer is described. The method has been characterized for the qualitative and quantitative label-free proteomic analysis of typical complex biological samples. The principle of the scanning quadrupole DIA method is discussed and analytical instrument characteristics, such as the quadrupole transmission width, scan/integration time, and chromatographic separation, have been optimized in relation to sample complexity for a number of different model proteomes of varying complexity and dynamic range including human plasma, cell lines, and bacteria...
September 13, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28890077/occlusion-dose-monitoring-in-amblyopia-therapy-status-insights-and-future-directions
#19
REVIEW
Catherine E Stewart, Merrick J Moseley, Pantelis Georgiou, Alistair R Fielder
Occlusion therapy remains the mainstay treatment of amblyopia, but its outcome is not assured or universally excellent. Many factors are known to influence treatment outcome, among which compliance is foremost. The occlusion dose monitor (ODM) removes one variable from the treatment equation, because it records the occlusion actually received by-rather than prescribed for-the child. Improvement observed can thus be quantitatively related to the patching received. This review summarizes the insights the ODM has provided to date particularly in elucidating the dose-response relationship...
September 7, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28888927/the-effects-of-improving-sleep-on-mental-health-oasis-a-randomised-controlled-trial-with-mediation-analysis
#20
Daniel Freeman, Bryony Sheaves, Guy M Goodwin, Ly-Mee Yu, Alecia Nickless, Paul J Harrison, Richard Emsley, Annemarie I Luik, Russell G Foster, Vanashree Wadekar, Christopher Hinds, Andrew Gumley, Ray Jones, Stafford Lightman, Steve Jones, Richard Bentall, Peter Kinderman, Georgina Rowse, Traolach Brugha, Mark Blagrove, Alice M Gregory, Leanne Fleming, Elaine Walklet, Cris Glazebrook, E Bethan Davies, Chris Hollis, Gillian Haddock, Bev John, Mark Coulson, David Fowler, Katherine Pugh, John Cape, Peter Moseley, Gary Brown, Claire Hughes, Marc Obonsawin, Sian Coker, Edward Watkins, Matthias Schwannauer, Kenneth MacMahon, A Niroshan Siriwardena, Colin A Espie
BACKGROUND: Sleep difficulties might be a contributory causal factor in the occurrence of mental health problems. If this is true, improving sleep should benefit psychological health. We aimed to determine whether treating insomnia leads to a reduction in paranoia and hallucinations. METHODS: We did this single-blind, randomised controlled trial (OASIS) at 26 UK universities. University students with insomnia were randomly assigned (1:1) with simple randomisation to receive digital cognitive behavioural therapy (CBT) for insomnia or usual care, and the research team were masked to the treatment...
October 2017: Lancet Psychiatry
keyword
keyword
87356
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"