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https://www.readbyqxmd.com/read/27852965/a-randomized-placebo-controlled-pilot-study-of-the-efficacy-and-safety-of-d-cycloserine-in-people-with-chronic-back-pain
#1
Thomas J Schnitzer, Souraya Torbey, Kristi Herrmann, Gagan Kaushal, Renita Yeasted, A Vania Apkarian
BACKGROUND: Few effective pharmacological treatment options exist for chronic back pain, the leading cause of disability in the US, and all are associated with significant adverse effects. OBJECTIVE: To determine the efficacy and safety of D-cycloserine, a partial agonist to the N-methyl-D-aspartate receptor, in the treatment of chronic low back pain. METHODS: A total of 41 participants with chronic back pain who met all inclusion and exclusion criteria were enrolled in a double-blind, placebo-controlled randomized pilot trial of D-cycloserine...
2016: Molecular Pain
https://www.readbyqxmd.com/read/27802054/surface-enhanced-femtosecond-stimulated-raman-spectroscopy-at-1-mhz-repetition-rates
#2
Lauren Elizabeth Buchanan, Natalie L Gruenke, Michael O McAnally, Bogdan Negru, Hannah E Mayhew, Vartkess Ara Apkarian, George C Schatz, Richard P Van Duyne
Surface-enhanced femtosecond stimulated Raman spectroscopy (SE-FSRS) is an ultrafast Raman technique that combines the sensitivity of surface-enhanced Raman scattering with the temporal resolution of femtosecond stimulated Raman spectroscopy (FSRS). Here, we present the first successful implementation of SE-FSRS using a 1 MHz amplified femtosecond laser system. We compare SE-FSRS and FSRS spectra measured at 1 MHz and 100 kHz using both equal pump average powers and equal pump energies to demonstrate that higher repetition rates allow spectra with higher signal-to-noise ratios to be obtained at lower pulse energies, a significant advance in the implementation of SE-FSRS...
November 1, 2016: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/27788130/brain-connectivity-predicts-placebo-response-across-chronic-pain-clinical-trials
#3
Pascal Tétreault, Ali Mansour, Etienne Vachon-Presseau, Thomas J Schnitzer, A Vania Apkarian, Marwan N Baliki
Placebo response in the clinical trial setting is poorly understood and alleged to be driven by statistical confounds, and its biological underpinnings are questioned. Here we identified and validated that clinical placebo response is predictable from resting-state functional magnetic-resonance-imaging (fMRI) brain connectivity. This also led to discovering a brain region predicting active drug response and demonstrating the adverse effect of active drug interfering with placebo analgesia. Chronic knee osteoarthritis (OA) pain patients (n = 56) underwent pretreatment brain scans in two clinical trials...
October 2016: PLoS Biology
https://www.readbyqxmd.com/read/27725689/global-disruption-of-degree-rank-order-a-hallmark-of-chronic-pain
#4
Ali Mansour, Alex T Baria, Pascal Tetreault, Etienne Vachon-Presseau, Pei-Ching Chang, Lejian Huang, A Vania Apkarian, Marwan N Baliki
Chronic pain remains poorly understood; yet it is associated with the reorganization of the nervous system. Here, we demonstrate that a unitary global measure of functional connectivity, defined as the extent of degree rank order disruption, kD, identifies the chronic pain state. In contrast, local degree disruption differentiates between chronic pain conditions. We used resting-state functional MRI data to analyze the brain connectome at varying scales and densities. In three chronic pain conditions, we observe disrupted kD, in proportion to individuals' pain intensity, and associated with community membership disruption...
October 11, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27408791/multisite-multimodal-neuroimaging-of-chronic-urological-pelvic-pain-methodology-of-the-mapp-research-network
#5
Jeffry R Alger, Benjamin M Ellingson, Cody Ashe-McNalley, Davis C Woodworth, Jennifer S Labus, Melissa Farmer, Lejian Huang, A Vania Apkarian, Kevin A Johnson, Sean C Mackey, Timothy J Ness, Georg Deutsch, Richard E Harris, Daniel J Clauw, Gary H Glover, Todd B Parrish, Jan den Hollander, John W Kusek, Chris Mullins, Emeran A Mayer
The Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network is an ongoing multi-center collaborative research group established to conduct integrated studies in participants with urologic chronic pelvic pain syndrome (UCPPS). The goal of these investigations is to provide new insights into the etiology, natural history, clinical, demographic and behavioral characteristics, search for new and evaluate candidate biomarkers, systematically test for contributions of infectious agents to symptoms, and conduct animal studies to understand underlying mechanisms for UCPPS...
2016: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27300256/hovering-and-twirling-of-tethered-molecules-by-confinement-between-surfaces
#6
Laura Rios, Joonhee Lee, Nicholas Tallarida, V Ara Apkarian
Through STM images, we show that azobenzene-terminated alkanethiols hover and twirl when confined between the Ag tip and Au(111) substrate of an STM junction. In contrast with mechanisms of activation used to drive molecular rotors, twirling is induced by the effective elimination of lateral corrugation in the energy landscape when molecules hover by their van der Waals attraction to the approaching tip. While in the stationary state the benzenes of the head group lie flat with an inter-ring separation of 7...
July 7, 2016: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/27190016/corticolimbic-anatomical-characteristics-predetermine-risk-for-chronic-pain
#7
Etienne Vachon-Presseau, Pascal Tétreault, Bogdan Petre, Lejian Huang, Sara E Berger, Souraya Torbey, Alexis T Baria, Ali R Mansour, Javeria A Hashmi, James W Griffith, Erika Comasco, Thomas J Schnitzer, Marwan N Baliki, A Vania Apkarian
SEE TRACEY DOI101093/BRAIN/AWW147 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: Mechanisms of chronic pain remain poorly understood. We tracked brain properties in subacute back pain patients longitudinally for 3 years as they either recovered from or transitioned to chronic pain. Whole-brain comparisons indicated corticolimbic, but not pain-related circuitry, white matter connections predisposed patients to chronic pain. Intra-corticolimbic white matter connectivity analysis identified three segregated communities: dorsal medial prefrontal cortex-amygdala-accumbens, ventral medial prefrontal cortex-amygdala, and orbitofrontal cortex-amygdala-hippocampus...
July 2016: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/27088781/pharmacotherapy-for-pain-in-a-family-with-inherited-erythromelalgia-guided-by-genomic-analysis-and-functional-profiling
#8
Paul Geha, Yang Yang, Mark Estacion, Betsy R Schulman, Hajime Tokuno, A Vania Apkarian, Sulayman D Dib-Hajj, Stephen G Waxman
IMPORTANCE: There is a need for more effective pharmacotherapy for chronic pain, including pain in inherited erythromelalgia (IEM) in which gain-of-function mutations of sodium channel NaV1.7 make dorsal root ganglion (DRG) neurons hyperexcitable. OBJECTIVE: To determine whether pain in IEM can be attenuated via pharmacotherapy guided by genomic analysis and functional profiling. DESIGN, SETTING, AND PARTICIPANTS: Pain in 2 patients with IEM due to the NaV1...
June 1, 2016: JAMA Neurology
https://www.readbyqxmd.com/read/27052584/novel-method-for-functional-brain-imaging-in-awake-minimally-restrained-rats
#9
Pei-Ching Chang, Daniel Procissi, Qiyuan Bao, Maria Virginia Centeno, Alex Baria, A Vania Apkarian
Functional magnetic resonance imaging (fMRI) in rodents holds great promise for advancing our knowledge about human brain function. However, the use of anesthetics to immobilize rodents during fMRI experiments has restricted the type of questions that can be addressed using this technique. Here we describe an innovative procedure to train rats to be constrained without the need of any anesthesia during the whole procedure. We show that with 8-10 days of acclimation rats can be conscious and remain still during fMRI experiments under minimal stress...
July 1, 2016: Journal of Neurophysiology
https://www.readbyqxmd.com/read/27042763/abnormalities-in-diffusional-kurtosis-metrics-related-to-head-impact-exposure-in-a-season-of-high-school-varsity-football
#10
Elizabeth M Davenport, Kalyna Apkarian, Christopher T Whitlow, Jillian E Urban, Jens H Jensen, Eliza Szuch, Mark A Espeland, Youngkyoo Jung, Daryl A Rosenbaum, Gerard A Gioia, Alexander K Powers, Joel D Stitzel, Joseph A Maldjian
The purpose of this study was to determine whether the effects of cumulative head impacts during a season of high school football produce changes in diffusional kurtosis imaging (DKI) metrics in the absence of clinically diagnosed concussion. Subjects were recruited from a high school football team and were outfitted with the Head Impact Telemetry System (HITS) during all practices and games. Biomechanical head impact exposure metrics were calculated, including: total impacts, summed acceleration, and Risk Weighted Cumulative Exposure (RWE)...
December 1, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/26965423/the-emotional-brain-as-a-predictor-and-amplifier-of-chronic-pain
#11
REVIEW
E Vachon-Presseau, M V Centeno, W Ren, S E Berger, P Tétreault, M Ghantous, A Baria, M Farmer, M N Baliki, T J Schnitzer, A V Apkarian
Human neuroimaging studies and complementary animal experiments now identify the gross elements of the brain involved in the chronification of pain. We briefly review these advances in relation to somatic and orofacial persistent pain conditions. First, we emphasize the importance of reverse translational research for understanding chronic pain-that is, the power of deriving hypotheses directly from human brain imaging of clinical conditions that can be invasively and mechanistically studied in animal models...
June 2016: Journal of Dental Research
https://www.readbyqxmd.com/read/26851921/a-theoretical-simulation-of-the-resonant-raman-spectroscopy-of-the-h2o%C3%A2-cl2-and-h2o%C3%A2-br2-halogen-bonded-complexes
#12
Ricardo Franklin-Mergarejo, Jesús Rubayo-Soneira, Nadine Halberstadt, Kenneth C Janda, V Ara Apkarian
The resonant Raman spectra of the H2O⋯Cl2 and H2O⋯Br2 halogen-bonded complexes have been studied in the framework of a 2-dimensional model previously used in the simulation of their UV-visible absorption spectra using time-dependent techniques. In addition to the vibrational progression along the dihalogen mode, a progression is observed along the intermolecular mode and its combination with the intramolecular one. The relative intensity of the inter to intramolecular vibrational progressions is about 15% for H2O⋯Cl2 and 33% for H2O⋯Br2...
February 7, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/26797510/reply
#13
LETTER
Bogdan Petre, Alexis T Baria, A Vania Apkarian
No abstract text is available yet for this article.
February 2016: Pain
https://www.readbyqxmd.com/read/26691834/the-indirect-pathway-of-the-nucleus-accumbens-shell-amplifies-neuropathic-pain
#14
Wenjie Ren, Maria Virginia Centeno, Sara Berger, Ying Wu, Xiaodong Na, Xianguo Liu, Jyothisri Kondapalli, A Vania Apkarian, Marco Martina, D James Surmeier
We examined adaptations in nucleus accumbens (NAc) neurons in mouse and rat peripheral nerve injury models of neuropathic pain. Injury selectively increased excitability of NAc shell indirect pathway spiny projection neurons (iSPNs) and altered their synaptic connectivity. Moreover, injury-induced tactile allodynia was reversed by inhibiting and exacerbated by exciting iSPNs, indicating that they not only participated in the central representation of pain, but gated activity in ascending nociceptive pathways...
February 2016: Nature Neuroscience
https://www.readbyqxmd.com/read/26460744/unique-microstructural-changes-in-the-brain-associated-with-urological-chronic-pelvic-pain-syndrome-ucpps-revealed-by-diffusion-tensor-mri-super-resolution-track-density-imaging-and-statistical-parameter-mapping-a-mapp-network-neuroimaging-study
#15
Davis Woodworth, Emeran Mayer, Kevin Leu, Cody Ashe-McNalley, Bruce D Naliboff, Jennifer S Labus, Kirsten Tillisch, Jason J Kutch, Melissa A Farmer, A Vania Apkarian, Kevin A Johnson, Sean C Mackey, Timothy J Ness, J Richard Landis, Georg Deutsch, Richard E Harris, Daniel J Clauw, Chris Mullins, Benjamin M Ellingson
Studies have suggested chronic pain syndromes are associated with neural reorganization in specific regions associated with perception, processing, and integration of pain. Urological chronic pelvic pain syndrome (UCPPS) represents a collection of pain syndromes characterized by pelvic pain, namely Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) and Interstitial Cystitis/Painful Bladder Syndrome (IC/PBS), that are both poorly understood in their pathophysiology, and treated ineffectively. We hypothesized patients with UCPPS may have microstructural differences in the brain compared with healthy control subjects (HCs), as well as patients with irritable bowel syndrome (IBS), a common gastrointestinal pain disorder...
2015: PloS One
https://www.readbyqxmd.com/read/26368493/supercontinuum-based-three-color-three-pulse-time-resolved-coherent-anti-stokes-raman-scattering
#16
Aram Zeytunyan, Kevin T Crampton, Ruben Zadoyan, Vartkess A Apkarian
We demonstrate the use of a photonic crystal fiber (PCF) as a compact three-color fs laser system operating at 76 MHz, limited only by the repetition rate of the pump laser. The system is suitable for background-free time-resolved four-wave mixing measurements, which arguably reach fundamental limits in signal detectivity. We give a detailed characterization of the near transform-limited multi-color pulses that are extracted from the PCF, and prove the system through time-resolved coherent anti-Stokes Raman scattering measurements in bipyridyl ethylene and styrene...
September 7, 2015: Optics Express
https://www.readbyqxmd.com/read/26348440/isomerization-of-one-molecule-observed-through-tip-enhanced-raman-spectroscopy
#17
Nicholas Tallarida, Laura Rios, Vartkess A Apkarian, Joonhee Lee
While exploring photoisomerization of azobenzyl thiols (ABT) adsorbed on Au(111), through joint scanning tunneling microscopy (STM) and tip-enhanced Raman scattering (TERS) studies, the reversible photoisomerization of one molecule is captured in TERS trajectories. The unique signature of single molecule isomerization is observed in the form of anticorrelated flip-flops between two distinct spectra with two discrete, on- and off-levels. The apparently heterogeneously photocatalyzed reaction is assigned to cis-trans isomerization of an outlier, which is chemisorbed on the silver tip of the STM...
October 14, 2015: Nano Letters
https://www.readbyqxmd.com/read/26313405/role-of-adult-hippocampal-neurogenesis-in-persistent-pain
#18
A Vania Apkarian, Amelia A Mutso, Maria V Centeno, Lixin Kan, Melody Wu, Marjorie Levinstein, Ghazal Banisadr, Kevin T Gobeske, Richard J Miller, Jelena Radulovic, René Hen, John A Kessler
The full role of adult hippocampal neurogenesis (AHN) remains to be determined, yet it is implicated in learning and emotional functions, and is disrupted in negative mood disorders. Recent evidence indicates that AHN is decreased in persistent pain consistent with the idea that chronic pain is a major stressor, associated with negative moods and abnormal memories. Yet, the role of AHN in development of persistent pain has remained unexplored. In this study, we test the influence of AHN in postinjury inflammatory and neuropathic persistent pain-like behaviors by manipulating neurogenesis: pharmacologically through intracerebroventricular infusion of the antimitotic AraC; ablation of AHN by x-irradiation; and using transgenic mice with increased or decreased AHN...
February 2016: Pain
https://www.readbyqxmd.com/read/26291217/raman-staircase-in-charge-transfer-sers-at-the-junction-of-fusing-nanospheres
#19
M Banik, V A Apkarian, T-H Park, M Galperin
We present a theoretical analysis of Raman intensities for a molecule that bridges a current carrying junction. Experimental data is used to estimate parameters for the theoretical model. The recently reported staircase of Raman intensities observed during the fusion of nanodumbbell is reproduced.
January 3, 2013: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/26247858/nociception-pain-negative-moods-and-behavior-selection
#20
REVIEW
Marwan N Baliki, A Vania Apkarian
Recent neuroimaging studies suggest that the brain adapts with pain, as well as imparts risk for developing chronic pain. Within this context, we revisit the concepts for nociception, acute and chronic pain, and negative moods relative to behavior selection. We redefine nociception as the mechanism protecting the organism from injury, while acute pain as failure of avoidant behavior, and a mesolimbic threshold process that gates the transformation of nociceptive activity to conscious pain. Adaptations in this threshold process are envisioned to be critical for development of chronic pain...
August 5, 2015: Neuron
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