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Anti cardiolipin antibody

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https://www.readbyqxmd.com/read/29908707/autoimmunity-and-b-cell-dyscrasia-in-acute-and-chronic-q-fever-a-review-of-the-literature
#1
REVIEW
Anne F M Jansen, Ruud P H Raijmakers, Stephan P Keijmel, Renate G van der Molen, Gerald M Vervoort, Jos W M van der Meer, Marcel van Deuren, Chantal P Bleeker-Rovers
Q fever infection can lead to chronic Q fever, a potentially lethal disease occurring in 1-5% of patients infected with Coxiella burnetii, characterized by the persistence of this intracellular bacterium. It usually presents as endocarditis, infected vascular aneurysms, or infected vascular prostheses. This systematic review of the literature discusses the various autoimmune syndromes and B-cell dyscrasias in acute and chronic Q fever patients, that may interfere with or impede recognition and diagnosis of Q fever...
June 13, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29901012/prognosis-in-pregnant-females-with-systemic-lupus-erythematosus
#2
Enling Liu, Yuxiu Zhou
Objectives: This study aims to analyze the relationship between pregnancy and lupus, and explore the risk factors that adversely affect maternal and infant outcomes. Patients and methods: The pregnancy outcomes in 112 pregnant females (mean age 24.3±2.8 years; range 20 to 35 years) with systemic lupus erythematosus (SLE) were retrospectively analyzed. Pregnancy outcomes before and after pregnancy were compared, and the associations with lupus nephritis, positive anti-Ro/SSA antibody, positive La/SSB antibody, complement 3 and complement 4, high blood pressure, positive anti- cardiolipin (aCL) antibody, Raynaud's phenomenon, and lupus recurrence were evaluated...
December 2017: Archives of Rheumatology
https://www.readbyqxmd.com/read/29883633/assessment-of-diagnostic-methods-for-the-detection-of-anticardiolipin-and-anti-%C3%AE-eta-2-glycoprotein-i-antibodies-in-patients-under-routine-evaluation-for-antiphospholipid-syndrome
#3
Thomas B Martins, Nahla Heikal, Jason Miller, Rohan Willis, Robert L Schmidt, Anne E Tebo
BACKGROUND: We assessed the performance characteristics and correlations of the traditional enzyme-linked immunosorbent assay (ELISA) and chemiluminescence immunoassay (CIA) for detecting IgG and IgM antibodies to cardiolipin (aCL) and beta2 glycoprotein (anti-β2 GPI) antibodies in patients under routine evaluation for APS. METHODS: Patients (n = 216) referred to ARUP Laboratories for lupus anticoagulant (LAC) and/or aCL or anti-β2 GPI IgG/IgM antibodies evaluation were assessed by ELISA and CIA methods...
June 5, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29881401/case-report-presenting-the-diagnostic-challenges-in-a-patient-with-recurrent-acquired-angioedema-antiphospholipid-antibodies-and-undetectable-c2-levels
#4
Arturo J Bonnin, Charles DeBrosse, Terri Moncrief, G Wendell Richmond
Background: Angioedema secondary to acquired C1 inhibitor deficiency (AAE) is a rare disease. It usually is associated with lymphoproliferative disorders. We present a case of AAE in a patient with antiphospholipid syndrome (APS), a non-Hodgkin lymphoproliferative disorder (NHL) with undetectable levels of C2, C4, and an undetectable CH50. The co-existence of AAE, APS, and NHL, with an undetectable C2 level, to the best of our knowledge, has never before reported together in the same patient...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/29846157/role-of-serum-autoantibodies-in-blood-brain-barrier-damages-in-neuropsychiatric-systemic-lupus-erythematosus
#5
Shunsei Hirohata, Yuko Sakuma, Yu Matsueda, Yoshiyuki Arinuma, Tamiko Yanagida
OBJECTIVES: The present study was carried out to elucidate the roles of serum autoantibodies in the development of blood-brain barrier (BBB) damages in neuropsychiatric systemic lupus erythematosus (NPSLE). METHODS: Paired serum and CSF samples were obtained from 101 SLE patients when they presented active neuropsychiatric manifestations (69 patients with diffuse psychiatric/neuropsychological syndromes [diffuse NPSLE] and 32 patients with neurologic syndromes or peripheral neuropathy [focal NPSLE])...
May 24, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29845583/anti-phospholipid-igg-antibodies-detected-by-line-immunoassay-differentiate-patients-with-anti-phospholipid-syndrome-and-other-autoimmune-diseases
#6
Cecilia Nalli, Valentina Somma, Laura Andreoli, Thomas Büttner, Peter Schierack, Michael Mahler, Dirk Roggenbuck, Angela Tincani
PURPOSE: Anti-phospholipid antibodies (aPL) analyzed by line immunoassay (LIA) can recognize beta2 -glycoprotein I (β2 GPI) domain 1 (D1) epitopes depending on β2 GPI binding to distinct phospholipids. The aPL LIA was compared with consensus ELISA to investigate whether both techniques can discriminate anti-phospholipid syndrome (APS) patients from aPL-positive, systemic autoimmune rheumatic diseases (SARD) patients without clinical symptoms of APS and controls. METHODS: Thirty-four APS patients (14 arterial/venous thrombosis, 16 pregnancy morbidity, and 4 both), 41 patients with SARD lacking clinical APS criteria but demonstrating positivity for anti-β2 GPI (aβ2 GPI) IgG, and 20 healthy subjects (HS) were tested for aPL to cardiolipin (aCL), phosphatidic acid, phosphatidylcholine, phosphatidylethanolamine, phosphatidylglycerol (aPG), phosphatidylinositol, phosphatidylserine, β2 GPI, prothrombin, and annexin V by LIA...
May 29, 2018: Auto- Immunity Highlights
https://www.readbyqxmd.com/read/29756580/subtypes-of-antiphospholipid-antibodies-in-neurologic-accidents-an-observational-study
#7
Maryam Sahebari, Maryam Rastin, Reza Boostani, Mohsen Forughipour, Kamila Hashemzadeh, Samira HaajSadeghi
OBJECTIVE: Until now, concomitant neurological manifestations and positive antiphospholipid antibodies (APA(s)) have been investigated in different manners. The most important conflicts in this field are whether those manifestations are directly related to APA(s) or not and treatment strategies. METHOD: In this study, adopting a different manner, we selected patients with a recently defined neurological problem (according to study protocol) and positive APA without any other risk factor, to compare types, amounts, and titer of APAs...
May 14, 2018: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/29701849/origin-of-nontreponemal-antibodies-during-treponema-pallidum-infection-evidence-from-a-rabbit-model
#8
Kun Gao, Xu Shen, Yong Lin, Xiao-Zhen Zhu, Li-Rong Lin, Man-Li Tong, Yao Xiao, Hui-Lin Zhang, Xian-Ming Liang, Jian-Jun Niu, Li-Li Liu, Tian-Ci Yang
The origin of nontreponemal antibodies during syphilis infection is hotly debated. Here, we analysed the immune response in rabbits immunized with various antigens. Inactivated treponemes elicited the production of low-titre nontreponemal antibodies in some rabbits. Cardiolipin combined with bovine serum albumin also induced anti-cardiolipin antibody production. These findings indicate that T. pallidum contained a cardiolipin antigen with weak immunogenicity. However, active T.pallidum induced higher nontreponemal antibody production with strong immunogenicity at an earlier time point, and the antibody titre was consecutive, suggesting the high nontreponemal antibody titre resulted from the combined effects of both the T...
April 25, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29697389/-rheological-properties-of-blood-serum-at-systemic-sclerosis
#9
A Zabara, S Selezneva, S Dubina, O Syniachenko
Systemic sclerosis (SSc) is accompanied by severe disorders of serum component of blood rheological properties (BRP), the study indicators of which performed as the monitoring of the therapeutic interventions effectiveness. BRP changes have not been established at different forms of SSc, the connection between physicochemical serum rheological properties and morphological signs of vascular skin lesions and extracardiac implications of the disease remains unknown. The purpose and objectives of the study - to evaluate the changes of BRP serum component with clinical and morphological variants of limited and diffuse form of SSc...
March 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29685012/evaluating-the-utility-of-autoantibodies-for-disease-activity-and-relapse-in-giant-cell-arteritis
#10
T Kuret, K Lakota, A Hočevar, B Burja, S Čučnik, S Sodin-Semrl
In patients with giant cell arteritis (GCA), autoantibodies against cytoskeletal elements, cardiolipin, neutrophil cytoplasmic antigens, ferritin, endothelial and smooth muscle cells have been reported, however no updated reviews are available evaluating their clinical utility. Methodology of detection is important, especially for quantitative assays, e.g. enzyme-linked immunoassays and multiplex beadbased immunoassays, while semiquantitative assays contribute valuable data on isoforms, epitope mapping and cellular localization...
March 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29565968/blood-coagulation-abnormalities-in-multibacillary-leprosy-patients
#11
Débora Santos da Silva, Lisandra Antonia Castro Teixeira, Daniela Gois Beghini, André Teixeira da Silva Ferreira, Márcia de Berredo Moreira Pinho, Patricia Sammarco Rosa, Marli Rambaldi Ribeiro, Monica Di Calafiori Freire, Mariana Andrea Hacker, José Augusto da Costa Nery, Maria Cristina Vidal Pessolani, Ana Maria Freire Tovar, Euzenir Nunes Sarno, Jonas Perales, Fernando Augusto Bozza, Danuza Esquenazi, Robson Queiroz Monteiro, Flavio Alves Lara
BACKGROUND: Leprosy is a chronic dermato-neurological disease caused by Mycobacterium leprae infection. In 2016, more than 200,000 new cases of leprosy were detected around the world, representing the most frequent cause of infectious irreversible deformities and disabilities. PRINCIPAL FINDINGS: In the present work, we demonstrate a consistent procoagulant profile on 40 reactional and non-reactional multibacillary leprosy patients. A retrospective analysis in search of signs of coagulation abnormalities among 638 leprosy patients identified 35 leprosy patients (5...
March 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29547897/performance-evaluation-and-clinical-associations-of-immunoassays-that-detect-antibodies-to-negatively-charged-phospholipids-other-than-cardiolipin
#12
Amaris Castanon, Grant Pierre, Rohan Willis, E Nigel Harris, Elizabeth Papalardo, Zurina Romay-Penabad, Alvaro Schleh, Praveen Jajoria, Monica Smikle, Karel DeCeulaer, Anne Tebo, Troy Jaskowski, Marta M Guerra, D Ware Branch, Jane E Salmon, Michelle Petri, Emilio B Gonzalez
Objectives: We evaluate the performance characteristics of antiphosphatidylserine (anti-PS), antiphosphatidylinositol (anti-PI), and antiphospholipid mixture (APhL) enzyme-linked immunosorbent assays (ELISAs) compared with anticardiolipin (aCL) and anti-β2 glycoprotein I (anti-β2GPI) in a large group of patients with antiphospholipid (aPL)-related diseases. Methods: Serum samples from 548 patients from the Hopkins and Jamaican systemic lupus erythematosus cohorts, the PROMISSE cohort, and the Antiphospholipid Standardization Laboratory were examined for immunoglobulin G (IgG)/immunoglobulin M (IgM) positivity in aCL, anti-β2GPI, anti-PS, anti-PI, and APhL ELISA assays...
March 29, 2018: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29532744/associations-between-maternal-clinical-features-and-fetal-outcomes-in-pregnancies-of-mothers-with-connective-tissue-diseases
#13
Ayako Ohyama, Hiroto Tsuboi, Hisashi Noma, Mayu Terasaki, Masaru Shimizu, Hirofumi Toko, Fumika Honda, Mizuki Yagishita, Hiroyuki Takahashi, Hiromitsu Asashima, Shinya Hagiwara, Yuya Kondo, Isao Matsumoto, Takayuki Sumida
OBJECTIVES: The purpose of this study is to clarify associations between maternal clinical features and adverse pregnancy outcomes (APOs) in mothers with connective tissue diseases (CTDs). METHODS: We retrospectively examined maternal clinical features including backgrounds, autoantibodies, CTD flare-ups, and therapies during pregnancies as well as fetal outcomes in 90 pregnancies (66 mothers) at our hospital from January 2006 to September 2016. RESULTS: Underlying CTDs were SLE (N = 41), MCTD (N = 10), RA (N = 15), SS (N = 10), and others (N = 14)...
April 5, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29524102/neurological-autoantibodies-in-drug-resistant-epilepsy-of-unknown-cause
#14
Mehmet Tecellioglu, Ozden Kamisli, Suat Kamisli, Fatma Ebru Yucel, Cemal Ozcan
BACKGROUND: Autoimmune epilepsy is a rarely diagnosed condition. Recognition of the underlying autoimmune condition is important, as these patients can be resistant to antiepileptic drugs. AIMS: To determine the autoimmune and oncological antibodies in adult drug-resistant epilepsy of unknown cause and identify the clinical, radiological, and EEG findings associated with these antibodies according to data in the literature. METHODS: Eighty-two patients with drug-resistant epilepsy of unknown cause were prospectively identified...
March 9, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29519741/hydralazine-associated-vasculitis-overlapping-features-of-drug-induced-lupus-and-vasculitis
#15
Bharat Kumar, Jennifer Strouse, Melissa Swee, Petar Lenert, Manish Suneja
INTRODUCTION: Hydralazine is an antihypertensive medication that has been associated with drug-induced lupus erythematosus (DIL) as well as ANCA-associated vasculitis (AAV). Although rare, early diagnosis is critical since drug cessation is the mainstay of therapy. This retrospective study aims to characterize the clinical, laboratory, and histopathologic features of this disease. METHODS: Once approval was obtained from the Institutional Review Board at the University of Iowa, all patients carrying a diagnosis of vasculitis (ICD9 code: 447...
January 12, 2018: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29483518/cardiolipin-exposure-on-the-outer-mitochondrial-membrane-modulates-%C3%AE-synuclein
#16
Tammy Ryan, Vladimir V Bamm, Morgan G Stykel, Carla L Coackley, Kayla M Humphries, Rhiannon Jamieson-Williams, Rajesh Ambasudhan, Dick D Mosser, Stuart A Lipton, George Harauz, Scott D Ryan
Neuronal loss in Parkinson's disease (PD) is associated with aberrant mitochondrial function and impaired proteostasis. Identifying the mechanisms that link these pathologies is critical to furthering our understanding of PD pathogenesis. Using human pluripotent stem cells (hPSCs) that allow comparison of cells expressing mutant SNCA (encoding α-synuclein (α-syn)) with isogenic controls, or SNCA-transgenic mice, we show that SNCA-mutant neurons display fragmented mitochondria and accumulate α-syn deposits that cluster to mitochondrial membranes in response to exposure of cardiolipin on the mitochondrial surface...
February 26, 2018: Nature Communications
https://www.readbyqxmd.com/read/29455451/both-b-1a-and-b-1b-cells-exposed-to-mycobacterium-tuberculosis-lipids-differentiate-into-igm-antibody-secreting-cells
#17
Ciara Ordoñez, Hannah P Savage, Musharaf Tarajia, René Rivera, Cheyenne Weeks-Galindo, Dilcia Sambrano, Lee Riley, Patricia L Fernandez, Nicole Baumgarth, Amador Goodridge
Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. The cellular immune response to mycobacteria has been characterized extensively, but the antibody response remains underexplored. The present study aimed to examine whether host or bacterial phospholipids induce secretion of IgM, and specifically anti-phospholipid IgM, antibodies by B cells and to identify the responsible B-cell subset. Here we show that peritoneal B cells responded to lipid antigens by secreting IgM antibodies. Specifically, stimulation with M...
February 18, 2018: Immunology
https://www.readbyqxmd.com/read/29313959/cardiolipin-activates-antigen-presenting-cells-via-tlr2-pi3k-pkn1-akt-p38-nf-kb-signaling-to-prime-antigen-specific-na%C3%A3-ve-t-cells-in-mice
#18
Jung-Ah Cho, Tae-Joo Kim, Hye-Jung Moon, Young-Joo Kim, Hye-Kyung Yoon, Seung-Yong Seong
Mitochondrial defects and antimitochondrial cardiolipin (CL) antibodies are frequently detected in autoimmune disease patients. CL from dysregulated mitochondria activates various pattern recognition receptors, such as NLRP3. However, the mechanism by which mitochondrial CL activates APCs as a damage-associated molecular pattern to prime antigen-specific naïve T cells, which is crucial for T-cell-dependent anticardiolipin IgG antibody production in autoimmune diseases is unelucidated. Here, we show that CL increases the expression of costimulatory molecules in CD11c+ APCs both in vitro and in vivo...
January 4, 2018: European Journal of Immunology
https://www.readbyqxmd.com/read/29301476/the-cutaneous-manifestations-are-significantly-related-to-cerebrovascular-in-a-serbian-cohort-of-patients-with-hughes-syndrome
#19
L Stojanovich, A Djokovic, N Stanisavljevic, M Zdravkovic
Objectives To investigate a possible relationship between cerebrovascular, such as stroke and transient ischaemic attack, and various cutaneous manifestations (livedo reticularis, skin ulcerations, pseudovasculitis lesions, superficial cutaneous necrosis and digital gangrene) in antiphospholipid syndrome (APS). This report is based on a Serbian cohort of APS patients. Methods A total of 508 antiphospholipid syndrome APS patients were assessed: 360 with primary (PAPS) and 148 with APS associated with SLE (SAPS)...
April 2018: Lupus
https://www.readbyqxmd.com/read/29238798/association-between-hypercoagulable-conditions-and-calciphylaxis-in-patients-with-renal-disease-a-case-control-study
#20
Allison S Dobry, Lauren N Ko, Jessica St John, J Mark Sloan, Sagar Nigwekar, Daniela Kroshinsky
Importance: Calciphylaxis is a rare skin disease with high morbidity and mortality that frequently affects patients with renal disease. Hypercoagulable conditions are frequently observed in both patients with calciphylaxis and those with chronic kidney disease (CKD), complicating our understanding of which hypercoagulable conditions are specific to calciphylaxis. Objective: To identify hypercoagulable conditions that are risk factors for developing calciphylaxis while controlling for CKD...
February 1, 2018: JAMA Dermatology
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