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development of large hips in women

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https://www.readbyqxmd.com/read/28651365/cathepsin-k-inhibitors-for-osteoporosis-biology-potential-clinical-utility-and-lessons-learned
#1
Matthew T Drake, Bart L Clarke, Merry Jo Oursler, Sundeep Khosla
Cathepsin K is a cysteine protease member of the cathepsin lysosomal protease family. While cathepsin K is highly expressed in osteoclasts, lower levels of cathepsin K are also found in a variety of other tissues. Secretion of cathepsin K from the osteoclast into the sealed osteoclast-bone cell interface results in efficient degradation of type I collagen. The absence of cathepsin K activity in humans results in pycnodysostosis, characterized by increased bone mineral density and fractures. Pharmacological cathepsin K inhibition leads to continuous increases in BMD for up to five years of treatment and improves bone strength at the spine and hip...
June 23, 2017: Endocrine Reviews
https://www.readbyqxmd.com/read/28528985/atrial-fibrillation-and-risk-of-hip-fracture-a-population-based-analysis-of-113-600-individuals
#2
Christopher X Wong, Siang Wei Gan, Sarah W Lee, Celine Gallagher, Ned J Kinnear, Dennis H Lau, Rajiv Mahajan, Kurt C Roberts-Thomson, Prashanthan Sanders
BACKGROUND: A number of cardiovascular diseases have been linked with bone health and an increased risk of osteoporotic fracture. Whether atrial fibrillation (AF) is associated with subsequent fracture risk is not known. METHODS: Administrative, clinical and hospitalisation information were linked over a 14-year period. From this longitudinal, population-based dataset of 113,600 individuals, time-dependent exposures using multivariate Cox proportional hazards regression models were employed to determine incidence rates and hazard ratios (HR) for hip fracture according to a history of AF...
May 5, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28492856/treatment-of-low-bone-density-or-osteoporosis-to-prevent-fractures-in-men-and-women-a-clinical-practice-guideline-update-from-the-american-college-of-physicians
#3
Amir Qaseem, Mary Ann Forciea, Robert M McLean, Thomas D Denberg
Description: This guideline updates the 2008 American College of Physicians (ACP) recommendations on treatment of low bone density and osteoporosis to prevent fractures in men and women. This guideline is endorsed by the American Academy of Family Physicians. Methods: The ACP Clinical Guidelines Committee based these recommendations on a systematic review of randomized controlled trials; systematic reviews; large observational studies (for adverse events); and case reports (for rare events) that were published between 2 January 2005 and 3 June 2011...
June 6, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28378985/aerobic-capacity-of-adults-with-intellectual-disabilities
#4
Krystyna Gawlik, Anna Zwierzchowska, Beata Manowska, Diana Celebańska
INTRODUCTION: Physical fitness is a resultant of the efficiency of adaptive mechanisms for physical effort. People with intellectual disabilities may exhibit limited adaptive capacities, not only regarding their mental development, but also physiological, social and emotional development. Dysfunctions of the central nervous system observed in individuals with intellectual disabilities cause difficulties in gaining movement experience as well as problems with coordination and kinesthetic sense...
December 31, 2016: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/28270503/age-at-first-birth-and-cardiovascular-risk-factors-in-the-1958-british-birth-cohort
#5
Rebecca E Lacey, Meena Kumari, Amanda Sacker, Anne McMunn
BACKGROUND: To assess relationships between age at first birth and cardiovascular risk factors in a large longitudinal study of men and women. By assessing associations for both genders, we were able to investigate biological versus social and behavioural explanations from early life through to adulthood. METHODS: Multiply-imputed data on more than 7600 men and women of a British birth cohort study (National Child Development Study, 1958 British birth cohort) were used...
July 2017: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/28076630/cutoffs-and-cardiovascular-risk-factors-associated-with-neck-circumference-among-community-dwelling-elderly-adults-a-cross-sectional-study
#6
Hélio José Coelho, Ricardo Aurélio Carvalho Sampaio, Ivan de Oliveira Gonçalvez, Samuel da Silva Aguiar, Rafael Palmeira, José Fernando de Oliveira, Ricardo Yukio Asano, Priscila Yukari Sewo Sampaio, Marco Carlos Uchida
CONTEXT AND OBJECTIVE: In elderly people, measurement of several anthropometric parameters may present complications. Although neck circumference measurements seem to avoid these issues, the cutoffs and cardiovascular risk factors associated with this parameter among elderly people remain unknown. This study was developed to identify the cutoff values and cardiovascular risk factors associated with neck circumference measurements among elderly people. DESIGN AND SETTING: Cross-sectional study conducted in two community centers for elderly people...
November 2016: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/27865615/association-between-the-dietary-inflammatory-index-waist-to-hip-ratio-and-metabolic-syndrome
#7
Alexis Sokol, Michael D Wirth, Marta Manczuk, Nitin Shivappa, Katarzyna Zatonska, Thomas G Hurley, James R Hébert
Inflammation due to poor diet may contribute to the development of metabolic syndrome (MetSyn). The Dietary Inflammatory Index (DII) was created to characterize diet on a scale from anti- to pro-inflammatory. Our hypothesis was that higher (i.e., more pro-inflammatory) DII scores are associated with an increased prevalence of MetSyn compared to those with lower (i.e., more anti-inflammatory) DII scores. Data from the Polish-Norwegian (PONS) Study were analyzed using logistic and linear regression procedures in SAS (version 9...
November 2016: Nutrition Research
https://www.readbyqxmd.com/read/27810307/standard-radiographs-are-not-sufficient-for-assessing-knee-mechanical-axis-in-patients-with-advanced-osteoarthritis
#8
Christopher D Stickley, Jennifer J Wages, Ronald K Hetzler, Samantha N Andrews, Cass K Nakasone
BACKGROUND: The use of standard radiographs, and measured tibiofemoral angle (TFA), to assess lower extremity alignment is commonly practiced despite limited knowledge of its relationship to the mechanical axis (MA), as measured on hip-to-ankle (HTA) radiographs. This study assessed the predictive accuracy of previously developed equations, developed gender-specific regression equations using predictors from standard radiographs, and the clinical effectiveness of these equations in a large sample of cases using HTA radiographs as a gold standard...
September 28, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/27754163/sy-11-3-hypertension-in-women-more-dangerous-than-in-men
#9
Suzanne Oparil
Heart disease, stroke, and kidney failure are leading causes of death worldwide, and hypertension is a significant risk factor for each. Hypertension is less common in women, compared to men, in those younger than 45 years of age. This trend is reversed in those 65 years and older. In the US between 2011-2014, the prevalence of hypertension in women and men by age group was 6% vs 8% (18-39 years), 30% vs 35% (40-59 years), and 67% vs 63% (60 years and over). Awareness, treatment, and control rates differ between genders with women being more aware of their diagnosis (85% vs 80%), more likely to take their medications (81% vs 71%) and more frequently having controlled hypertension (55% vs 49%)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27746495/epidemiology-of-knee-osteoarthritis-in-india-and-related-factors
#10
Chandra Prakash Pal, Pulkesh Singh, Sanjay Chaturvedi, Kaushal Kumar Pruthi, Ashok Vij
BACKGROUND: Among the chronic rheumatic diseases, hip and knee osteoarthritis (OA) is the most prevalent and is a leading cause of pain and disability in most countries worldwide. Its prevalence increases with age and generally affects women more frequently than men. OA is strongly associated with aging and heavy physical occupational activity, a required livelihood for many people living in rural communities in developing countries. Determining region-specific OA prevalence and risk factor profiles will provide important information for planning future cost effective preventive strategies and health care services...
September 2016: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/27650643/the-frax-based-lebanese-osteoporosis-treatment-guidelines-rationale-for-a-hybrid-model
#11
M Chakhtoura, W D Leslie, M McClung, A M Cheung, G El-Hajj Fuleihan
We describe our approach to develop FRAX-based osteoporosis treatment guidelines in Lebanon, a country with low-moderate fracture rates. A hybrid assessment algorithm that combines a fixed 10 % intervention threshold until age 70 years, and an age-dependent threshold thereafter, was deemed most suitable. INTRODUCTION: The FRAX risk calculator is used to guide intervention thresholds in several national osteoporosis guidelines. This study aimed to describe the approach in developing FRAX-based osteoporosis treatment guidelines in Lebanon, a country with relatively low fracture rates...
January 2017: Osteoporosis International
https://www.readbyqxmd.com/read/27643118/sy-11-3-hypertension-in-women-more-dangerous-than-in-men
#12
Suzanne Oparil
Heart disease, stroke, and kidney failure are leading causes of death worldwide, and hypertension is a significant risk factor for each. Hypertension is less common in women, compared to men, in those younger than 45 years of age. This trend is reversed in those 65 years and older. In the US between 2011-2014, the prevalence of hypertension in women and men by age group was 6% vs 8% (18-39 years), 30% vs 35% (40-59 years), and 67% vs 63% (60 years and over). Awareness, treatment, and control rates differ between genders with women being more aware of their diagnosis (85% vs 80%), more likely to take their medications (81% vs 71%) and more frequently having controlled hypertension (55% vs 49%)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27167420/-eleven-year-experience-with-total-ankle-arthroplasty
#13
S Popelka, A Sosna, P Vavřík, D Jahoda, V Barták, I Landor
UNLABELLED: PURPOSE OF THE STUDY Total joint replacement is one of the options in surgical treatment of advanced ankle arthritis. It allows the ankle to remain mobile but, unfortunately, it does not provide the same longevity as total knee or hip replacements. Therefore, decisions concerning the kind of treatment are very individual and depend on the clinical status and opinion of each patient. MATERIAL AND METHODS A total of 132 total ankle replacements were carried out in the period from 2004 to 2015...
2016: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
https://www.readbyqxmd.com/read/27150344/no-benefit-after-tha-performed-with-computer-assisted-cup-placement-10-year-results-of-a-randomized-controlled-study
#14
RANDOMIZED CONTROLLED TRIAL
Sebastien Parratte, Matthieu Ollivier, Alexandre Lunebourg, Xavier Flecher, Jean-Noel A Argenson
BACKGROUND: Computer-assisted surgery (CAS) for cup placement has been developed to improve the functional results and to reduce the dislocation rate and wear after total hip arthroplasty (THA). Previously published studies demonstrated radiographic benefits of CAS in terms of implant position, but whether these improvements result in clinically important differences that patients might perceive remains largely unknown. QUESTIONS/PURPOSES: We hypothesized that THA performed with CAS would improve 10-year patient-reported outcomes measured by validated scoring tools, reduce acetabular polyethylene wear as measured using a validated radiological method, and increase survivorship...
October 2016: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/26886646/prediction-of-large-joint-destruction-in-patients-with-rheumatoid-arthritis-using-18f-fdg-pet-ct-and-disease-activity-score
#15
Takahito Suto, Koichi Okamura, Yukio Yonemoto, Chisa Okura, Yoshito Tsushima, Kenji Takagishi
The assessments of joint damage in patients with rheumatoid arthritis (RA) are mainly restricted to small joints in the hands and feet. However, the development of arthritis in RA patients often involves the large joints, such as the shoulder, elbow, hip, knee, and ankle. Few studies have been reported regarding the degree of large joint destruction in RA patients. F-fluorodeoxyglucose positron emission tomography combined with computed tomography (FDG-PET/CT) visualizes the disease activity in large joints affected by RA...
February 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26876620/could-larger-diameter-of-4th-generation-ceramic-bearing-decrease-the-rate-of-dislocation-after-tha
#16
Young-Kyun Lee, Yong-Chan Ha, Woo-Lam Jo, Tae-Young Kim, Woon-Hwa Jung, Kyung-Hoi Koo
BACKGROUND: Fourth generation (Delta) ceramic bearing was developed to reduce dislocation after total hip arthroplasty (THA) by increasing the head diameter. We tested a hypothesis that 32/36 mm Delta ceramic bearing decreases the dislocation rate. We also evaluated ceramic-related complications and early outcome of this thin liner-on-large head ceramic bearing. METHODS: We performed a prospective study on patients who underwent THA with use of 32/36 mm Delta ceramic bearing...
May 2016: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/26788786/waist-to-hip-ratio-versus-body-mass-index-as-predictor-of-obesity-related-pregnancy-outcomes
#17
Mollie McDonnold, Lisa M Mele, Leslie Myatt, John C Hauth, Kenneth J Leveno, Uma M Reddy, Brian M Mercer
Objective In nonpregnant populations the waist-to-hip ratio (WHR) is a better predictor of obesity-related outcomes than body mass index (BMI). Our objective was to determine, in pregnancy, the relationship between these measures of obesity, and large-for-gestational age (LGA) and cesarean delivery (CD). Methods This is a secondary analysis of data from the Combined Antioxidant and Preeclampsia Prediction Study. Women with a WHR of ≥ 0.85 and 0.80 to 0.84 at 9 to 16 weeks gestation were compared with those with a WHR < 0...
May 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/26530649/pseudotumour-incidence-cobalt-levels-and-clinical-outcome-after-large-head-metal-on-metal-and-conventional-metal-on-polyethylene-total-hip-arthroplasty-mid-term-results-of-a-randomised-controlled-trial
#18
RANDOMIZED CONTROLLED TRIAL
H C van der Veen, I H F Reininga, W P Zijlstra, M F Boomsma, S K Bulstra, J J A M van Raay
We compared the incidence of pseudotumours after large head metal-on-metal (MoM) total hip arthroplasty (THA) with that after conventional metal-on-polyethylene (MoP) THA and assessed the predisposing factors to pseudotumour formation. From a previous randomised controlled trial which compared large head (38 mm to 60 mm) cementless MoM THA with conventional head (28 mm) cementless MoP THA, 93 patients (96 THAs: 41 MoM (21 males, 20 females, mean age of 64 years, standard deviation (sd) 4) and 55 MoP (25 males, 30 females, mean age of 65 years, sd 5) were recruited after a mean follow-up of 50 months (36 to 64)...
November 2015: Bone & Joint Journal
https://www.readbyqxmd.com/read/26389086/a-frax-experience-in-korea-fracture-risk-probabilities-with-a-country-specific-versus-a-surrogate-model
#19
Yong-Ki Min, Dong-Yun Lee, Youn-Soo Park, Young-Wan Moon, Seung-Jae Lim, Young-Kyun Lee, DooSeok Choi, Byung-Koo Yoon
BACKGROUND: Recently, a Korean fracture-risk assessment tool (FRAX) model has become available, but large prospective cohort studies, which are needed to validate the model, are still lacking, and there has been little effort to evaluate its usefulness. This study evaluated the clinical usefulness of the FRAX model, a FRAX developed by the World Health Organization, in Korea. METHODS: In 405 postmenopausal women and 139 men with a proximal femoral fracture, 10-year predicted fracture probabilities calculated by the Korean FRAX model (a country-specific model) were compared with the probabilities calculated with a FRAX model for Japan, which has a similar ethnic background (surrogate model)...
August 2015: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/26379953/an-epidemiological-study-of-risk-factors-of-thyroid-nodule-and-goiter-in-chinese-women
#20
Lei Zheng, Wenhua Yan, Yue Kong, Ping Liang, Yiming Mu
Thyroid nodule (TN) and goiter are two common disorders of the thyroid. Despite their benign nature, both conditions are associated with multiple pathologic conditions including thyroiditis, endocrine dysregulation, and autoimmune disease. In this study we conducted a large-scale epidemiological study in Chinese women to identify risk factors implicated in the pathogenesis of TN and goiter. We analyzed demographic data, medical history, menstrual status, smoking, alcohol consumption, body height, weight, waist circumference, and body mass index (BMI)...
2015: International Journal of Clinical and Experimental Medicine
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