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https://www.readbyqxmd.com/read/29127996/highlights-in-immune-response-microbiome-and-precision-medicine-in-allergic-disease-and-asthma
#1
EDITORIAL
Milena Sokolowska, Cezmi A Akdis
Several recent key findings in immunology of allergic diseases that have led to a need of reassessment of our current thinking are reviewed in this issue of the journal. Recently developed strong evidence on the role of hygiene hypothesis in protection from allergic disease and its immune mechanisms is reviewed by Ober et al. The authors pointed out immunologic mechanisms of lower prevalence of asthma and allergic sensitization observed among Amish children living on traditional farms with higher endotoxin levels as compared to Hutterite children living on industrialized farms...
October 2017: Current Opinion in Immunology
https://www.readbyqxmd.com/read/29122155/rituximab-hypersensitivity-evaluation-desensitization-and-potential-mechanisms
#2
Johnson T Wong, Aidan Long
BACKGROUND: Rituximab (Rituxan) hypersensitivity (RITS) can be severe and limits the ability to further administer the treatment. Understanding its pattern and desensitization may permit administration in difficult cases. OBJECTIVE: Analyze RITS patient characteristics, hypersensitivity pattern, and desensitization outcomes to optimize management. METHODS: Twenty-five patients with RITS were referred to the Allergy/Immunology Unit at Massachusetts General Hospital over 5 1/2 years...
November 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29122154/feeling-burned-out-half-of-us-are-the-urgent-need-to-address-provider-health-and-wellness-in-allergy-and-immunology
#3
EDITORIAL
Theresa Bingemann, David A Khan, Sharon Markovics, Andrew G Weinstein, Hemant P Sharma
No abstract text is available yet for this article.
November 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29119328/endoplasmic-reticulum-stress-and-allergic-diseases
#4
REVIEW
Jae Seok Jeong, So Ri Kim, Seong Ho Cho, Yong Chul Lee
PURPOSE OF REVIEW: In this review, we will integrate recent knowledge on endoplasmic reticulum (ER) stress and allergy, thereby highlighting the therapeutic potential of ER stress in the context of precision medicine for allergic diseases. RECENT FINDINGS: Emerging evidence suggests that allergic diseases are very heterogeneous having numerous endotypes. This leads to the new era of modern medicine, which assumes that a particular endotype-driven therapy, called precision medicine, would be more efficacious in a specific group of patients rather than in all patients...
November 8, 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/29118674/high-frequency-of-ige-sensitization-towards-kiwi-seed-storage-proteins-among-peanut-allergic-individuals-also-reporting-allergy-to-kiwi
#5
Jenny van Odijk, Sigrid Sjölander, Peter Brostedt, Magnus P Borres, Hillevi Englund
Background: IgE sensitization to storage proteins from nuts and seed is often related to severe allergic symptoms. There is a risk of immunological IgE cross-reactivity between storage proteins from different species. The potential clinical implication of such cross-reactivity is that allergens other than the known sensitizer can cause allergic symptoms. Previous studies have suggested that kiwi seed storage proteins may constitute hidden food allergens causing cross-reactive IgE-binding with peanut and other tree nut homologs, thereby mediating a potential risk of causing allergy symptoms among peanut ant tree nut allergic individuals...
2017: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/29108766/new-insight-into-cancer-immunotherapy
#6
REVIEW
M M Escribese, D Barber
A key point for maintenance of the immune system homeostasis is the balance between the capacity to recognize and fight exogenous molecules and the capacity to avoid auto reactivity. The disruption of this balance induces the progression of several immune diseases such as autoimmune diseases, allergies, infections or cancer. A promising therapeutic approach to treat these diseases is immunotherapy. In cancer, both active and passive immunotherapies have been tested with promising results, such as the blocking of immunological checkpoints like CTLA-4 and PD-1...
November 3, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/29108604/global-issues-in-allergy-and-immunology-parasitic-infections-and-allergy
#7
REVIEW
Alvaro A Cruz, Philip J Cooper, Camila A Figueiredo, Neuza M Alcantara-Neves, Laura C Rodrigues, Mauricio L Barreto
Allergic diseases are on the increase globally in parallel with a decrease in parasitic infection. The inverse association between parasitic infections and allergy at an ecological level suggests a causal association. Studies in human subjects have generated a large knowledge base on the complexity of the interrelationship between parasitic infection and allergy. There is evidence for causal links, but the data from animal models are the most compelling: despite the strong type 2 immune responses they induce, helminth infections can suppress allergy through regulatory pathways...
November 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29106324/safety-of-specific-immunotherapy-using-an-ultra-rush-induction-regimen-in-bee-and-wasp-allergy
#8
Andrzej Bożek, Krzysztof Kołodziejczyk
BACKGROUND: Specific allergen immunotherapy to Hymenoptera venom (VIT) is a basic treatment for patients allergic to Hymenoptera venom. The aim of the study was to evaluate the safety of an ultra-rush regimen compared with the rush and conventional protocols. MATERIALS AND METHODS: In 31 patients with an allergy to bee venom and 82 with an allergy to wasp venom, the allergic adverse reactions during VIT were monitored. Patients were selected based on the criteria established by EAACI (European Academy of Allergy and Clinical Immunology) recommendations...
November 6, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29105313/immunological-changes-induced-in-peach-allergy-patients-with-systemic-reactions-by-pru-p-3-sublingual-immunotherapy
#9
Francisca Palomares, Francisca Gomez, Gador Bogas, Campo Paloma, James Richard Perkins, A Diaz-Perales, Maria José Rodriguez, Ana Prieto, Domingo Barber, María José Torres, Cristobalina Mayorga
SCOPE: Sublingual immunotherapy using peach extract enriched in Pru p 3 (Pru p 3-enriched-SLIT) brings a new perspective to treating patients with allergy to lipid transfer proteins. We evaluated the immunological changes induced by Pru p 3-enriched-SLIT during one year. METHODS AND RESULTS: Three groups were included: peach allergic patients who received Pru p 3-enriched-SLIT, peach allergic untreated patients and controls. Peripheral blood mononuclear cells were obtained before treatment and different time-points...
November 3, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29103800/allergy-and-immunology-practice-parameters-and-guidelines-the-new-normal
#10
EDITORIAL
David M Lang, Jay M Portnoy
No abstract text is available yet for this article.
November 2, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29103799/american-college-of-allergy-asthma-immunology-position-paper-on-the-use-of-telemedicine-for-allergists
#11
Tania Elliott, Jennifer Shih, Chitra Dinakar, Jay Portnoy, Stanley Fineman
The integration of telecommunications and information systems in health care first began 4 decades ago with 500 patient consultations performed via interactive television. The use of telemedicine services and technology to deliver health care at a distance is increasing exponentially. Concomitant with this rapid expansion is the exciting ability to provide enhancements in quality and safety of care. Telemedicine enables increased access to care, improvement in health outcomes, reduction in medical costs, better resource use, expanded educational opportunities, and enhanced collaboration between patients and physicians...
November 2, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29093235/pollen-serum-specific-ige-sensitization-in-respiratory-allergic-patients-in-jakarta-indonesia
#12
Iris Rengganis, Agus Joko Susanto
BACKGROUND: pollens from trees or grasses in Indonesia have a perennial distribution due to the tropical climate. However, pollen allergy has not been well studied. This study aimed to evaluate the profile of pollen IgE sensitization in respiratory allergic patients in Jakarta. METHODS: this was a cross-sectional study in patients with a history of respiratory allergy in Jakarta, Indonesia between September and December 2016. Adult asthmatic patients aged 19-60 years were invited to undergo serum specific IgE testing at the Allergy and Immunology Clinic, Cipto Mangunkusumo Hospital, Jakarta...
July 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/29069535/emerging-roles-of-innate-lymphoid-cells-in-inflammatory-diseases-clinical-implications
#13
REVIEW
Inge Kortekaas Krohn, Medya Mara Shikhagaie, Korneliusz Golebski, Jochem H J Bernink, Christine Breynaert, Brecht Creyns, Zuzana Diamant, Wytske J Fokkens, Philippe Gevaert, Peter Hellings, Rudi W Hendriks, Ludger Klimek, Jenny Mjösberg, Hideaki Morita, Graham Ogg, Liam O'Mahony, Jürgen Schwarze, Sven F Seys, Mohamed H Shamji, Suzanne M Bal
Innate lymphoid cells (ILC) represent a group of lymphocytes that lack specific antigen receptors and are relatively rare as compared to adaptive lymphocytes. ILCs play important roles in allergic and non-allergic inflammatory diseases due to their location at barrier surfaces within the airways, gut and skin and they respond to cytokines produced by activated cells in their local environment. ILCs contribute to the immune response by the release of cytokines and other mediators, forming a link between innate and adaptive immunity...
October 25, 2017: Allergy
https://www.readbyqxmd.com/read/29068090/early-introduction-of-allergenic-foods-for-the-prevention-of-food-allergy-from-an-asian-perspective-an-apapari-consensus-statement
#14
REVIEW
E H Tham, L P Shek, H P Van Bever, P Vichyanond, M Ebisawa, G W K Wong, B W Lee
Emerging evidence for the early introduction of allergenic foods for the prevention of food allergies, such as peanut allergy in Western populations, has led to the recent publication of guidelines in the US and Europe recommending early peanut introduction for high-risk infants with severe eczema or egg allergy. Peanut allergy is, however, much less prevalent in Asia compared to the West. Varying patterns of food allergy are seen even within Asian countries - such as a predominance of wheat allergy in Japan and Thailand and shellfish allergy in Singapore and the Philippines...
October 25, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29067711/food-allergy-in-eaaci-journals-2016
#15
REVIEW
Ulrich Wahn, Paolo M Matricardi, Thomas Bieber, Jean Bousquet, Clive Grattan, Hans-Uwe Simon, Antonella Muraro, Ioana Agache
The European Academy of Allergy and Clinical Immunology (EAACI) owns three journals: Allergy, Pediatric Allergy and Immunology and Clinical and Translational Allergy. One of the major goals of EAACI is to understand and better manage food allergy, and to disseminate the knowledge of allergy to all stakeholders including the EAACI junior members (1). The European Symposium on Precision Medicine in Allergy and Airways Diseases at the European Union Parliament (October 14, 2015) stressed that the socioeconomic impact of food allergy (2)...
October 25, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29065408/low-dose-allergen-specific-immunotherapy-induces-tolerance-in-a-murine-model-of-shrimp-allergy
#16
Nicki Yat Hin Leung, Christine Yee Yan Wai, Shang An Shu, Christopher C Chang, Ka Hou Chu, Patrick S C Leung
BACKGROUND: The efficacy and safety of allergen-specific immunotherapy (AIT) are highly dose-dependent. METHODS: We investigated the dosage effects of AIT and the underlying mechanisms in a murine model of shrimp hypersensitivity. BALB/c mice were sensitized with recombinant shrimp allergen rMet e 1 and challenged orally with a high dose of rMet e 1 to elicit an allergic response. These sensitized mice were then treated with a low (0.01 mg), medium (0.05 mg), or high dosage (0...
2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29051540/genome-wide-association-study-identifies-the-serpinb-gene-cluster-as-a-susceptibility-locus-for-food-allergy
#17
Ingo Marenholz, Sarah Grosche, Birgit Kalb, Franz Rüschendorf, Katharina Blümchen, Rupert Schlags, Neda Harandi, Mareike Price, Gesine Hansen, Jürgen Seidenberg, Holger Röblitz, Songül Yürek, Sebastian Tschirner, Xiumei Hong, Xiaobin Wang, Georg Homuth, Carsten O Schmidt, Markus M Nöthen, Norbert Hübner, Bodo Niggemann, Kirsten Beyer, Young-Ae Lee
Genetic factors and mechanisms underlying food allergy are largely unknown. Due to heterogeneity of symptoms a reliable diagnosis is often difficult to make. Here, we report a genome-wide association study on food allergy diagnosed by oral food challenge in 497 cases and 2387 controls. We identify five loci at genome-wide significance, the clade B serpin (SERPINB) gene cluster at 18q21.3, the cytokine gene cluster at 5q31.1, the filaggrin gene, the C11orf30/LRRC32 locus, and the human leukocyte antigen (HLA) region...
October 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/29047174/pediatric-allergy-and-immunology-in-china
#18
REVIEW
Gary Wk Wong, Jing Li, Yi-Xiao Bao, Jiu-Yao Wang, Ting Fan Leung, Luan-Luan Li, Jie Shao, Xin-Yuan Huang, En-Mei Liu, Shen Kun-Ling, Chen Yu-Zhi
Over the past thirty years, China has enjoyed rapid economic development along with urbanization at a massive scale that the world has not experienced before. Such development has also been associated with a rapid rise in the prevalence of allergic disorders. Because of the large childhood population in the country, the burden of childhood allergic disorders has become one of the major challenges in the health care system. Among the Chinese centers participating in the International Study of Asthma and Allergies in Childhood clearly, the data showed a continuing rise in the prevalence of asthma, allergic rhinitis and atopic eczema...
October 19, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29046194/the-role-of-intravenous-access-during-oral-food-challenges-in-food-protein-induced-enterocolitis-syndrome
#19
Laura E Pena, Danielle Guffey, Charles G Minard, Sara Anvari, Carla M Davis
BACKGROUND: Food protein-induced enterocolitis syndrome (FPIES) is a non-immunoglobulin E mediated food hypersensitivity syndrome characterized by profuse vomiting and diarrhea, which leads to lethargy, dehydration, and hypotension. Given the potential severity of reactions, resolution of FPIES is confirmed via oral food challenge (OFC) during which intravenous (IV) access is recommended to facilitate IV fluids (IVF) and steroid therapy. Risk factors for IV treatment are not well characterized...
November 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/29045815/eosinophils-and-eosinophil-associated-diseases-an-update
#20
Jeremy A O'Sullivan, Bruce S Bochner
The goal of this series is to offer a survey of the latest literature for clinicians and scientists alike, providing a list of important recent advances relevant to the broad field of allergy and immunology. This particular assignment was to cover the topic of eosinophils. In an attempt to highlight major ideas, themes, trends and advances relevant to basic and clinical aspects of eosinophil biology, a search of papers published since 2015 in JACI and other high impact journals was performed. Manuscripts were then reviewed and organized, and then key findings were summarized...
October 15, 2017: Journal of Allergy and Clinical Immunology
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