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allergy immunology

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https://www.readbyqxmd.com/read/29791010/new-eaaci-definition-on-pollen-season-mirrors-symptom-load-for-grass-and-birch-pollen-induced-allergic-rhinitis
#1
Kostas Karatzas, Nikos Katsifarakis, Marina Riga, Barbora Werchan, Matthias Werchan, Uwe Berger, Oliver Pfaar, Karl-Christian Bergmann
BACKGROUND: The use of allergen immunotherapy (AIT) for allergic rhinitis and its clinical efficacy in clinical trials depends on the effective determination of pollen allergens exposure time-periods. We evaluate pollen data from Germany to examine the new definitions on pollen season and peak pollen period start and end as proposed by the European Academy of Allergy and Clinical Immunology (EAACI) in a recently published Position Paper. The aim was to demonstrate the ability of these definitions to mirror symptom loads for grass and birch pollen-induced allergic rhinitis based on real-life data...
May 23, 2018: Allergy
https://www.readbyqxmd.com/read/29783251/prevalence-of-risk-factors-of-allergic-diseases-among-children-aged-8-9-years-in-poltava-region-the-results-of-the-first-stage-of-the-research
#2
Tetyana O Kryuchko, Iryna A Holovanova, Olha Y Tkachenko, Mariya O Melnyk, Kateryna V Pocheniuk
OBJECTIVE: Introduction: According to the European Academy of Allergology and Clinical Immunology (EAACI, 2016), allergy is the most common chronic disease in Europe. The aim: The aim of the investigation is to study the spread of risk factors of allergic reactions in children who are 8-9 years old of Poltava region. PATIENTS AND METHODS: Materials and methods: The investigation included two stages: the 1st contained interviewing; the 2nd one - additional clinical and lab investigation of children, who require the further diagnosis specification...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29782070/evolving-patterns-in-the-diagnosis-and-management-of-allergy-mediated-disorders
#3
Khashayar Arianpour, Peter F Svider, Brian Yuhan, Zamaan Hooda, Jean Anderson Eloy, Adam J Folbe
BACKGROUND: This analysis explores the increasing heterogeneity of trends in allergy management under the premise that the practice of allergy has undergone significant changes in national economics, healthcare delivery, and treatment options from 2007 to 2016. METHODS: Centers for Medicare and Medicaid Services (CMS) data were obtained for: (1) temporal trends in allergy immunotherapy injection (Current Procedural Terminology [CPT] codes 95115, 95117) and testing (CPT 95004, 95024) from 2007 to 2016; (2) geographic trends; and (3) practitioners administering immunotherapy...
May 21, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29779967/a-comparison-of-the-united-states-and-international-perspective-on-chronic-urticaria-guidelines
#4
REVIEW
Torsten Zuberbier, Jonathan A Bernstein
Urticaria is a heterogeneous skin disorder that may be acute or chronic and is defined by the appearance of wheals, angioedema, or both. The European perspective is expressed in a recent international guideline and the American perspective has been based on the US Joint Task Force chronic urticaria practice parameter published in 2014. Both the international guideline (initiated by the European societies European Academy of Allergology and Clinical Immunology [EAACI]/Global Allergy and Asthma European Network [GA2 LEN]/European Dermatology Forum [EDF] in collaboration with the World Allergy Organization [WAO]) and the US (American Academy of Allergy, Asthma & Immunology/American College of Allergy, Asthma and Immunology) guideline have been developed to help direct primary care physicians and specialists in the management of their patients with urticaria...
May 18, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29778490/the-molecular-allergology-of-subtropical-grass-pollen
#5
Thina Kailaivasan, Janet M Davies
Grass pollens are amongst the most important aeroallergen sources world-wide triggering allergic rhinoconjunctivitis and asthma in sensitised patients. Much of what we know about the allergen components of grasses is informed by research on pollen of temperate (Pooideae) species that are abundant in the temperate climate zones. However, climate changes are altering the biogeographical distribution as well as timing and allergenicity of grass pollens. This provides an impetus for better understanding of the contribution of subtropical subfamilies of grasses to pollen allergy globally...
May 16, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29777733/food-allergy-guidance-in-the-united-states-military-a-work-group-report-from-the-aaaai-military-allergy-and-immunology-assembly-maia
#6
Kirk Waibel, Rachel Lee, Christopher Coop, Yun Mendoza, Kevin White
A diagnosis of food allergy adversely impacts one's ability to join or remain in the military. Inadequate knowledge or misconceptions of current military-specific standards regarding food allergy and how these apply to enlistment, induction, and retention in the United States military can potentially lead to inaccurate counseling as each military service has specific regulations which impact the evaluation and decision-making process. Recognizing this knowledge gap, the American Allergy, Asthma, and Immunology (AAAAI) Military Allergy and Immunology Assembly (MAIA) established a Work Group who reviewed and summarized all aspects of military instructions, policies, and regulations regarding IgE mediated food allergy...
May 16, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29775468/conflicts-of-interest-of-editors-of-medical-journals
#7
Waqas Haque, Abu Minhajuddin, Arjun Gupta, Deepak Agrawal
BACKGROUND: Almost all medical journals now require authors to publicly disclose conflicts of interests (COI). The same standard and scrutiny is rarely employed for the editors of the journals although COI may affect editorial decisions. METHODS: We conducted a retrospective observational study to determine the prevalence and magnitude of financial relationships among editors of 60 influential US medical journals (10 each for internal medicine and five subspecialties: cardiology, gastroenterology, neurology, dermatology and allergy & immunology)...
2018: PloS One
https://www.readbyqxmd.com/read/29762208/prevalence-of-atopic-dermatitis-and-pattern-of-drug-therapy-in-malaysian-children
#8
Yi-Yeong Goh, Fazlollah Keshavarzi, Yik Ling Chew
BACKGROUND: Atopic dermatitis (AD) is a chronic relapsing, noncontagious skin inflammation characterized by dry skin and itch. Mutation in filaggrin gene leads to defective skin barrier, allowing entry of allergen and eliciting immunological response. OBJECTIVES: The aims of this study were to investigate the prevalence of AD in Malaysian children and to understand the pattern of drug therapy. Such information could be useful to establish the relationship between ethnicity and family history of atopy and the development of associated signs and symptoms...
May 2018: Dermatitis
https://www.readbyqxmd.com/read/29761483/epithelial-barrier-dysfunctions-in-atopic-dermatitis-a-skin-gut-lung-model-linking-microbiome-alteration-and-immune-dysregulation
#9
REVIEW
T H Zhu, T R Zhu, K A Tran, R K Sivamani, V Y Shi
Atopic dermatitis is a systemic disorder characterized by abnormal barrier function across multiple organ sites. Initial disruption in the skin epidermal barrier permits allergen sensitization and colonization by pathogens. This induces TH 2 inflammatory response and a thymic stromal lymphopoietin mediated pathway that further promotes barrier breakdown at distant sites including the intestinal and respiratory tract. Clinically, atopic dermatitis can progress from skin disease to food allergy, allergic rhinitis, and later asthma, a phenomenon commonly known as the atopic march...
May 15, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29760877/an-eaaci-task-force-report-recognising-the-potential-of-the-primary-care-physician-in-the-diagnosis-and-management-of-drug-hypersensitivity
#10
REVIEW
I Doña, J C Caubet, K Brockow, M Doyle, E Moreno, I Terreehorst, M J Torres
Adverse drug reactions include drug hypersensitivity reactions (DHRs), which can be immunologically mediated (allergy) or non-immunologically mediated. The high number of DHRs that are unconfirmed and often self-reported is a frequent problem in daily clinical practice, with considerable impact on future prescription choices and patient health. It is important to distinguish between hypersensitivity and non-hypersensitivity reactions by adopting a structured diagnostic approach to confirm or discard the suspected drug, not only to avoid life-threatening reactions, but also to reduce the frequent over-diagnosis of DHRs...
2018: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29760613/latex-immunotherapy-evidence-of-effectiveness
#11
Eleonora Nucera, Simona Mezzacappa, Alessandro Buonomo, Michele Centrone, Angela Rizzi, Paolo Francesco Manicone, Giampiero Patriarca, Arianna Aruanno, Domenico Schiavino
Introduction: The only etiological and decisive therapy, able to influence the natural history of latex allergy is the specific desensitization. Aim: To verify the clinical efficacy and immunological changes determined by latex sublingual immunotherapy in allergic patients who underwent this treatment for at least 3 years. Material and methods: We enrolled 76 patients (16 males and 60 females, mean age 34 years old) with evidence of a natural rubber latex allergy...
April 2018: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29758487/maternal-allergy-as-an-isolated-risk-factor-for-early-onset-preeclampsia-an-epidemiological-study
#12
Anne Kvie Sande, Erik Andreas Torkildsen, Ragnar Kvie Sande, Nils-Halvdan Morken
Immunological mechanisms underlying the development of preeclampsia are well known, but no association to allergy has yet been demonstrated. The aim of this study was to assess the correlation between maternal pre-gestational allergy, and early-onset and late-onset preeclampsia, respectively. It was a retrospective cohort study including all women giving birth in the Norwegian cities of Stavanger (1996-2014) and Bergen (2009-2014). Pre-gestational asthma, allergy, other known risk factors for preeclampsia, maternal age and parity were obtained from the electronic medical record system...
June 2018: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29758291/dr-elliot-f-ellis-initiating-personalized-asthma-management-in-children
#13
Stanley J Szefler
Elliot F. Ellis is indeed a giant in the field of allergy and immunology. From his leadership role in developing a pediatric allergy and immunology fellowship at National Jewish Health and his seminal work in theophylline pharmacokinetics, he trained many excellent clinicians and researchers. He assumed the role of Chair of Pediatrics at the Children's Hospital of Buffalo in 1974 and transformed that training program in pediatrics to a top-rated program in the country along with his own training program in allergy and immunology...
May 11, 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29752554/secondary-hypogammaglobulinemia-after-rituximab-for-neuromyelitis-optica-a-case-report
#14
Lara Farhat, Jasmeen Dara, Susan Duberstein, Aliva De
A 17-year-old male with history of neuromyelitis optica and seizures presented to the pulmonology clinic for evaluation of recurrent pneumonias. He had received rituximab for the past 6 years. Over the past 2 years, he experienced four episodes of pneumonia. In between these episodes, he would improve briefly but continued to have daily cough that was productive with yellow phlegm. He also had recurrent rhinitis and sinusitis despite multiple antibiotic courses. Review of chest X-rays revealed localized right middle lobe and right lower lobe infiltrates...
May 11, 2018: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/29751365/the-interplay-between-risk-and-preventive-factors-explains-why-some-children-develop-allergies-to-certain-foods-and-others-show-tolerance
#15
REVIEW
Sami Remes, Petri Kulmala
AIM: A number of studies have clarified the tolerance mechanisms and risk factors for food allergies. Our aim was to explore food allergy symptoms by target organs, together with the risk factors and how to prevent food allergies and induce tolerance. METHODS: We carried out a thorough review of studies on paediatric food allergies published in the last decade. RESULTS: Food allergy symptoms may affect the skin, nasal and oral mucosa, conjunctivae, gastrointestinal tract, or, in severe cases, the respiratory tract and cardiovascular organs...
May 11, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29751152/the-use-of-telemedicine-for-penicillin-allergy-skin-testing
#16
Mary L Staicu, Anne Marie Holly, Kelly M Conn, Allison Ramsey
BACKGROUND: Penicillin skin testing (PST) is increasingly utilized as a tool to evaluate penicillin allergy in patients with a reported history. The limited availability of allergists, however, may be an impeding factor. OBJECTIVE: We sought to assess the clinical utility of telemedicine to facilitate PST. METHODS: Penicillin allergic inpatients receiving systemic antibiotics were prospectively identified between April and August 2017. Qualifying patients underwent PST performed by a trained Allergy/Immunology physician assistant (PA)...
May 8, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29732294/shellfish-crustacean-oral-allergy-syndrome-among-national-service-pre-enlistees-in-singapore
#17
Bernard Yu-Hor Thong, Shalini Arulanandam, Sze-Chin Tan, Teck-Choon Tan, Grace Yin-Lai Chan, Justina Wei-Lyn Tan, Mark Chong-Wei Yeow, Chwee-Ying Tang, Jinfeng Hou, Khai-Pang Leong
Background: All Singaporean males undergo medical screening prior to compulsory military service. A history of possible food allergy may require referral to a specialist Allergy clinic to ensure that special dietary needs can be taken into account during field training and deployment. Objective: To study the pattern of food allergy among pre-enlistees who were referred to a specialist allergy clinic to work up suspected food allergy. Methods: Retrospective study of all pre-enlistees registered in the Clinical Immunology/Allergy New Case Registry referred to the Allergy Clinic from 1 August 2015 to 31 May 2016 for suspected food allergy...
April 2018: Asia Pacific Allergy
https://www.readbyqxmd.com/read/29728509/functional-and-immunoreactive-levels-of-igg4-correlate-with-clinical-responses-during-the-maintenance-phase-of-house-dust-mite-immunotherapy
#18
Mulin Feng, Qiujuan Su, Xuxin Lai, Mo Xian, Xu Shi, Peter Adler Wurtzen, Rundong Qin, Xiaohui Zeng, Jing Li
Allergen-specific immunotherapy for house dust mite allergy is effective, but there are no validated biomarkers reflecting or predicting the clinical efficacy. We aimed to investigate the relationship between clinical outcomes and functional responses of allergen-specific IgG4 (sIgG4) and specific IgE (sIgE) during Dermatophagoides pteronyssinus s.c. allergen immunotherapy (SCIT) in allergic rhinitis and/or asthma patients. Combined symptom medication scores (SMS), D. pteronyssinus -sIgG4 levels, D. pteronyssinus -sIgE levels, and the serum inhibitory capacity against D...
May 4, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29727886/-food-allergy-theory-and-praxis
#19
Uta Jappe
Allergies manifest differently in every patient: Even when the same allergen source is the causing agent, means of sensitization and complexity of symptoms can vary strongly across patients. This often complicates the prevention, diagnostics and therapy of food allergies - or even makes them impossible. This article gives an overview of the underlying immunological principles of food-allergies, as well as of the current therapeutic and diagnostic approaches.
May 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29726281/exopolysaccharide-from-bifidobacterium-longum-subsp-longum-35624%C3%A2-modulates-murine-allergic-airway-responses
#20
E Schiavi, S Plattner, N Rodriguez-Perez, W Barcik, R Frei, R Ferstl, M Kurnik-Lucka, D Groeger, R Grant, J Roper, F Altmann, D van Sinderen, C A Akdis, L O'Mahony
Interactions between the host and the microbiota are thought to significantly influence immunological tolerance mechanisms at mucosal sites. We recently described that the loss of an exopolysaccharide (EPS) from Bifidobacterium longum 35624™ eliminated its protective effects in colitis and respiratory allergy murine models. Our goal was to investigate the immune response to purified EPS from B. longum 35624, determine if it has protective effects within the lung and identify the protective mechanisms. Isolated EPS from B...
May 4, 2018: Beneficial Microbes
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