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Haiyan Xu, Fei Xu, Wenjie Zhu, Jianming Ying, Yan Wang
BACKGROUND: Platinum-based chemotherapy is the standard first-line treatment for patients with advanced pan-negative non-squamous (non-Sq) non-small cell lung cancer (NSCLC). However, it is unknown which chemotherapy regimen confers the greatest benefit in such patients. This study explored which chemotherapy regimens were advantageous in non-Sq NSCLC patients. METHODS: A retrospective study was conducted on 114 patients with advanced non-Sq NSCLC using platinum-based chemotherapy in a first-line setting between January 2013 and December 2015...
June 19, 2018: Thoracic Cancer
Kachorn Seresirikachorn, Wirach Chitsuthipakorn, Dichapong Kanjanawasee, Likhit Khattiyawittayakun, Kornkiat Snidvongs
BACKGROUND: A combination of H1 antihistamine (AH) with intranasal corticosteroid (INCS) is commonly prescribed to patients with allergic rhinitis (AR) who have an inadequate response to monotherapy. In this systematic review we aimed to determine the effects of AH combined with INCS (AH-INCS) for treating AR. METHODS: Literature searches were performed using Medline and Embase. Randomized, controlled trials that studied the effects of AH-INCS vs INCS monotherapy for treating patients with AR were included...
June 19, 2018: International Forum of Allergy & Rhinology
John Ym Lam, Frank Voyvodic, Melissa Jenkins, Steven Knox
INTRODUCTION: Pelvic MRI has an increasingly important role in the evaluation of non-malignant uterine pathology including uterine leiomyomas, adenomyosis and endometriosis. Normal physiological myometrial junctional zone transient contractions can also be identified on MRI and have the potential to act as pathology mimics. This study aims to evaluate both the incidence of visible physiological contractions in premenopausal female pelvic MRI and also to support the routine acquisition of a repeat T2 sagittal sequence to differentiate transient physiological contractions from true underlying pathology and therefore improve observer confidence...
June 19, 2018: Journal of Medical Imaging and Radiation Oncology
Mehrnoosh Sedighi, Afshin Nazari, Mahdieh Faghihi, Mahmoud Rafieian-Kopaei, Arash Karimi, Maryam Moghimian, Seyyed Ali Mozaffarpur, Marzieh Rashidipour, Mehrdad Namdari, Mostafa Cheraghi, Bahram Rasoulian
Cinnamomum zeylanicum (cinnamon) is a plant with potent antioxidant activity and has been used in traditional medicine for improvement of heart function. The effects of cinnamon bark ethanolic extract were investigated against ischemia-induced arrhythmias and heart injury in an in vivo rat model of regional heart ischemia. The extract was also standardized, and its antioxidant activity was evaluated. Adult male Sprague-Dawley rats were subjected to 30 min of ischemia by occlusion of the left anterior descending coronary artery followed by 5 days of reperfusion...
June 19, 2018: Phytotherapy Research: PTR
Abul-Fotouh Ahmed, Mahmoud Shaban, Abdullah Daoud, Nagah Mohamed, Ahmed Solyman, Ahmed Fahim
In this study, we evaluated the relationship between haemodialysis (HD) duration and erectile function status and gonadal hormones serum levels in adult men with end-stage renal disease (ESRD). A total of 118 men with ESRD on chronic HD were eligible for analysis. The erectile dysfunction (ED) was defined and graded according to the international index of erectile function (IIEF-5) score. The serum levels of follicle stimulating hormones (FSH), luteinising hormone (LH), testosterone (TST), prolactin (PRL) and estradiol (E2) were measured using the standard laboratory technique...
June 19, 2018: Andrologia
Hirosumi Tamura, Arisa Higa, Hirotaka Hoshi, Gen Hiyama, Nobuhiko Takahashi, Masae Ryufuku, Gaku Morisawa, Yuka Yanagisawa, Emi Ito, Jun-Ichi Imai, Yuu Dobashi, Kiyoaki Katahira, Shu Soeda, Takafumi Watanabe, Keiya Fujimori, Shinya Watanabe, Motoki Takagi
Patient-derived tumor xenograft models represent a promising preclinical cancer model that better replicates disease, compared with traditional cell culture; however, their use is low-throughput and costly. To overcome this limitation, patient-derived tumor organoids (PDOs) were established from human lung, ovarian and uterine tumor tissues, among others, to accurately and efficiently recapitulate the tissue architecture and function. PDOs were able to be cultured for >6 months, and formed cell clusters with similar morphologies to their source tumors...
June 18, 2018: Oncology Reports
Loreto Castellon, Daniel Jerez, Jaime Mayorga, Alejandra Gallego, Carlos Fuenzalida, German Laissle
: Mandibular reconstruction in pediatric patients is controversial. The scant pediatric experience and the infrequent occurrence of this type of pathology in children complicate therapeutic decisions. The literature contains different treatment protocols and describes the bone graft alternatives to be used. MATERIALS AND METHOD: This is a retrospective review of patients under the age of 15 who were subjected to resection and reconstruction. RESULTS: A total of 18 patients were included in the study: 8 women and 10 men...
June 18, 2018: Journal of Craniofacial Surgery
Luis D Medina, Linda Hirshberg, Michael J Taylor, Paul E Gilbert, Robert K Heaton
BACKGROUND/OBJECTIVE: Fibromyalgia (FM) is a chronic pain syndrome of unknown etiology that can include subjective cognitive symptoms and variable evidence of cognitive dysfunction. Rates of occurrence and severity of cognitive impairment remain unclear. Additionally, comparison of this group with other pain conditions has been limited. The current cross-sectional study sought to identify rates of clinically significant cognitive impairment in FM and rheumatoid arthritis (RA) using an automated clinical rating approach...
June 18, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
Animesh Jain, Josh Bricker, Michael D Kappleman, Jennifer L Dotson
The impact of obesity on pediatric Crohn's disease (CD) remains poorly characterized. We aimed to evaluate disease related outcomes in overweight and obese children with CD, compared to normal weight children. We conducted a retrospective cohort study of children with newly diagnosed CD enrolled in the ImproveCareNow (ICN) Network. Patients were stratified into normal weight, overweight and obese groups using standardized weight percentiles. A total of 898 children were included, with 87 children (10%) being overweight and 43 children (5%) being obese; baseline characteristics were similar between groups...
June 18, 2018: Journal of Pediatric Gastroenterology and Nutrition
Christian Schmidkonz, Michael Cordes, Michael Beck, Theresa Ida Goetz, Daniela Schmidt, Olaf Prante, Tobias Bäuerle, Alexander Cavallaro, Michael Uder, Bernd Wullich, Peter Goebell, Torsten Kuwert, Philipp Ritt
BACKGROUND: We investigated the role of Tc-MIP-1404 (Progenics Pharmaceuticals, Inc, New York, NY) SPECT/CT of PSMA expression in the assessment of treatment response in patients with metastatic prostate cancer. METHODS: We retrospectively analyzed Tc-MIP-1404 SPECT/CT scans from 28 patients with metastatic prostate cancer examined before initiation and after completion of therapy. Eight of these patients had been treated with androgen deprivation therapy, 10 with docetaxel, and another 10 with external beam radiotherapy...
June 19, 2018: Clinical Nuclear Medicine
Iván Mañero Vazquez, Oihane García-Senosiain, Trinidad Labanca, Esther Gómez Gil
BACKGROUND: In male-to-female genital sex reassignment surgery, the clitoris, its prepuce, and the labia minora remain among the most difficult structures to construct. We describe the authors' clitoroplasty and vulvoplasty technique. METHODS: All patients who underwent male-to-female sex reassignment surgery at a single center, between June 2012 and June 2016, were prospectively included. The standard pedicled island neurovascular flap of the glans penis was harvested in a letter M fashion with attached preputial skin...
June 19, 2018: Annals of Plastic Surgery
Liliana Bordeianou, Christy E Cauley, Ruchin Patel, Ronald Bleday, Sadiqa Mahmood, Kevin Kennedy, Khawaja F Ahmed, Deborah Yokoe, David Hooper, Marc Rubin
OBJECTIVE: Create and validate diverticulitis surgical site infection prediction scale. BACKGROUND: Surgical site infections cause significant morbidity after colorectal surgery. An infection prediction scale could target infection prevention bundles to high-risk patients. METHODS: Prospectively collected National Surgical Quality Improvement Program and electronic medical record data obtained on diverticulitis colectomy patients across a Healthcare Network-wide Colorectal Surgery Collaborative (5 hospitals)...
June 18, 2018: Annals of Surgery
Kamal Maheshwari, Sandeep Khanna, Gausan Ratna Bajracharya, Natalya Makarova, Quinton Riter, Syed Raza, Jacek B Cywinski, Maged Argalious, Andrea Kurz, Daniel I Sessler
BACKGROUND: Intraoperative hypotension is associated with postoperative mortality. Early detection of hypotension by continuous hemodynamic monitoring might prompt timely therapy, thereby reducing intraoperative hypotension. We tested the hypothesis that continuous noninvasive blood pressure monitoring reduces intraoperative hypotension. METHODS: Patients ≥45 years old with American Society of Anesthesiologists physical status III or IV having moderate-to-high-risk noncardiac surgery with general anesthesia were included...
June 14, 2018: Anesthesia and Analgesia
Congyu Liao, Kang Wang, Xiaozhi Cao, Yueping Li, Dengchang Wu, Huihui Ye, Qiuping Ding, Hongjian He, Jianhui Zhong
Purpose To improve diagnosis of hippocampal sclerosis (HS) in patients with mesial temporal lobe epilepsy (MTLE) by using MR fingerprinting and compare with visual assessment of T1- and T2-weighted MR images. Materials and Methods For this prospective study performed between April and November 2016, T1 and T2 maps were obtained and tissue segmentation performed in consecutive patients with drug-resistant MTLE with unilateral or bilateral HS. T1 and T2 maps were compared between 33 patients with MTLE (23 women and 10 men; mean age, 32...
June 19, 2018: Radiology
Kevin A Eng, Aryan Abadeh, Carolina Ligocki, Yvonne K Lee, Rahim Moineddin, Thomasin Adams-Webber, Suzanne Schuh, Andrea S Doria
Purpose To evaluate the sensitivity, specificity, and diagnostic odds ratios of US, CT, and MRI as second-line imaging modalities after initial US for assessing acute appendicitis in children and adults. Materials and Methods A literature search was conducted in Medline and Embase to identify articles that used surgery or histopathologic examination alone or in combination with clinical follow-up or chart review to evaluate the diagnostic accuracy of second-line imaging modalities. The quality of articles was assessed by using the Quality Assessment of Diagnostic Accuracy Studies-2 and the Standards for Reporting of Diagnostic Accuracy tools...
June 19, 2018: Radiology
Kyoung Doo Song, Min Woo Lee, Hyunchul Rhim, Tae Wook Kang, Dong Ik Cha, Dong Hyun Sinn, Hyo Keun Lim
Purpose To evaluate the technical feasibility and therapeutic outcomes of percutaneous US/MRI fusion-guided radiofrequency ablation (RFA) of recurrent subcentimeter-sized hepatocellular carcinomas (HCCs). Materials and Methods For this retrospective study, between January 2012 and December 2014 a total of 194 planning US examinations were performed in 186 patients (159 men and 27 women; mean age, 61.1 years ± 10.0 [standard deviation]) for newly developed subcentimeter recurrent HCCs. These recurrent HCCs were defined as hypervascular nodules (>5...
June 19, 2018: Radiology
Gunnar Nordin
BACKGROUND: The accuracy and trueness of results from a laboratory test, such as the HbA1c test, should not be taken for granted but must be checked continuously. A tool for this is the participation in external quality assessment (EQA) for all laboratories performing the HbA1c-test. An additional possibility to detect changes in trueness is to monitor variations in patient cohort mean or median values that is not explained by changes in treatment or selection of patients. METHODS: Results reported to an EQA scheme for HbA1c during 20 years have been extracted from Equalis database...
June 1, 2018: Journal of Diabetes Science and Technology
Deborah Queiroz Freitas, Rocharles Cavalcante Fontenele, Eduarda Helena Leandro Nascimento, Taruska Ventorini Vasconcelos, Marcel Noujeim
AIM: To evaluate the influence of kilovoltage (kVp) and metal artefact reduction tool (MAR) on the magnitude of cone beam computed tomography (CBCT) artifacts. METHODS: A titanium and zirconia implants were inserted alternately in a posterior region of a mandible. CBCT exams were acquired with ProMax 3D (Planmeca Oy, Helsinki, Finland) and Picasso Trio machines (Vatech, Hwaseong, South Korea) using 70 kVp, 80 kVp and 90 kVp with and without MAR activation. The other exposure factors remained fixed at 5mA, FOV 80 × 50 mm and voxel 0...
June 19, 2018: Dento Maxillo Facial Radiology
Yoshitaka Honma, Takashi Terauchi, Ukihide Tateishi, Daisuke Kano, Kengo Nagashima, Hirokazu Shoji, Satoru Iwasa, Atsuo Takashima, Ken Kato, Tetsuya Hamaguchi, Narikazu Boku, Yasuhiro Shimada, Yasuhide Yamada
OBJECTIVE: Peritoneal metastasis (PM) is the most frequent form of metastasis in gastric cancer (GC). The sensitivity of detecting PM by preoperative imaging modalities is low. Utility of positron emission tomography (PET) with 18F-fluorodeoxiglucose (FDG) for GC is limited, because diffuse-type tumors are not FDG-avid. 18 F-fluorothymidine ([F-18]FLT) is a radiotracer that reflects cellular proliferation and the utility of [F-18]FLT-PET in GC has been reported. In this proof-of-concept study, we explored the ability of [F-18]FLT-PET/CT to detect PM of GC previously identified by other imaging modalities...
June 19, 2018: British Journal of Radiology
Giovanni D'Addio, Luigi Iuppariello, Paolo Bifulco, Bernardo Lanzillo, Nicola Pappone, Mario Cesarelli
OBJECTIVES: Smart fabrics and interactive textiles are a relatively new area of research, with many potential applications in the field of biomedical engineering. The ability of smart textiles to interact with the body provides a novel means to sense the wearer's physiology and respond to the needs of the wearer. Physiological signals, such as heart rate, breathing rates, and activity levels, are useful indicators of health status. These signals can be measured by means of textile-based sensors integrated into smart clothing which has the ability to keep a digital record of the patient's physiological responses since his or her last clinical visit, allowing doctors to make a more accurate diagnosis...
December 2017: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
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