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https://www.readbyqxmd.com/read/28087364/aquaglyceroporins-are-the-entry-pathway-of-boric-acid-in-trypanosoma-brucei
#1
Sabrina Marsiccobetre, Alexis Rodríguez-Acosta, Florian Lang, Katherine Figarella, Néstor L Uzcátegui
The boron element possesses a range of different effects on living beings. It is essential to beneficial at low concentrations, but toxic at excessive concentrations. Recently, some boron-based compounds have been identified as promising molecules against Trypanosoma brucei, the causative agent of sleeping sickness. However, until now, the boron metabolism and its access route into the parasite remained elusive. The present study addressed the permeability of T. brucei aquaglyceroporins (TbAQPs) for boric acid, the main natural boron species...
January 10, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28079322/-incidence-of-non-work-related-sickness-absence-in-spain-by-economic-activity-of-the-company
#2
Fernando G Benavides, Elena Zaballa, Xavier Duran, Victòria Sanchez-Niubo, David Gimeno Ruiz de Porras
INTRODUCTION: The management of sickness absence due to non-work-related diseases in Spain has typically focused on the control of its duration. The goal of this study was to provide estimates for the incidence of sickness absence due to nonwork-related diseases by economic activity to help shift the focus of management of sickness absence towards prevention. METHODS: Retrospective study based on 646,337 workers and 133,812 episodes of sickness absence started in 2009, from the Working Continuous Life Sample...
January 2017: Archivos de Prevención de Riesgos Laborales
https://www.readbyqxmd.com/read/28077608/-holiday-sickness-reported-exploratory-outcome-of-over-500-united-kingdom-holidaymakers-with-travellers-diarrhoea
#3
Prof Aali J Sheen, M Saad B Zahid, Andrew Fagbemi, Catherine Fullwood, Kathryn Whitehead
AIMS: To ascertain any predictors of potential food poisoning pathogens and development of post-infective irritable bowel syndrome (IBS) in UK travellers. An analysis was undertaken on prospectively collected data on 527 patients reporting symptoms of suspected food poisoning between June 2012 and June 2015. MAIN OUTCOME MEASURES: Positive stool sample indicative of food poisoning pathogens and diagnosis of post-infective IBS. RESULTS: Data on 527 patients were examined...
January 2017: Journal of Travel Medicine
https://www.readbyqxmd.com/read/28077587/malaria-parasitemia-and-parasite-density-in-antiretroviral-treated-hiv-infected-adults-following-discontinuation-of-cotrimoxazole-prophylaxis
#4
Ronald K Ottichilo, Christina S Polyak, Bernard Guyah, Benson Singa, Josphat Nyataya, Krista Yuhas, Grace John-Stewart, John N Waitumbi
BACKGROUND:  Cotrimoxazole (CTX) discontinuation increases malaria incidence in human immunodeficiency virus (HIV)-infected individuals. Rates, quantity, and timing of parasitemia rebound following CTX remain undefined. METHODS:  Serial specimens from a trial of HIV-infected individuals receiving antiretroviral treatment (ART) randomized to continue (the CTX arm) or discontinue (the STOP-CTX arm) were examined for malaria parasites by quantitative reverse transcription polymerase chain reaction (PCR)...
January 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28077115/local-mandate-improves-equity-of-paid-sick-leave-coverage-seattle-s-experience
#5
Jennifer L Romich
BACKGROUND: Paid sick leave allows workers to take time off work for personal or family health needs, improving health and potentially limiting infectious diseases. The U.S. has no national sick leave mandate, and many American workers - particularly those at lower income levels - have no right to paid time off for their own or family members' health needs. This article reports on outcomes of a local mandate, the City of Seattle Paid Sick and Safe Time Ordinance, which requires certain employers to provide paid sick leave to eligible workers...
January 11, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28077111/cumulative-exposure-to-shift-work-and-sickness-absence-associations-in-a-five-year-historic-cohort
#6
Alwin van Drongelen, Cécile R L Boot, Hynek Hlobil, Allard J van der Beek, Tjabe Smid
BACKGROUND: Exposure to shift work has been associated with negative health consequences, although the association between shift work and sickness absence remains unclear. The aim of this study is to investigate associations between cumulative exposure to shift work and sickness absence among ground staff employees of an airline company. METHODS: This study used data from the MORE (Monitoring Occupational Health Risks in Employees) cohort, which is a 5-year historic cohort...
January 11, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28076993/evaluation-of-clinical-and-serological-findings-for-diagnosis-of-cutaneous-anthrax-infection-after-an-outbreak
#7
Duygu Gulseren, Serap Süzük-Yıldız, Bekir Çelebi, Selçuk Kılıç
PURPOSE: Anthrax, caused by the bacterium Bacillus anthracis, is one of the oldest documented infectious diseases in both livestock and humans.We aimed to evaluate clinical findings and risk factors of patients with cutaneous anthrax infection and report anti-lethal factor (LF) IgG and anti-protective antigene (PA) IgG titers in the serologic diagnosis of disease. METHODS: In this study, serum samples of 18 cutaneous anthrax patients were collected and anti-LF IgG and anti-PA IgG titers were measured by enzyme-linked immunosorbent assay (ELISA)...
January 11, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28076589/time-volunteered-on-community-health-activities-by-brigadistas-in-nicaragua
#8
Meredith Adamo, Dixmer Rivera, Rashed Shah, Jeanne Koepsell, Leonel Martínez, Justo Pastor Ortiz, Carlos José Jarquín Navarrete, David R Marsh
Objective: To report on how brigadistas ("health brigadiers") in Nicaragua volunteer their time before the introduction of expanded responsibilities (beyond the scope of integrated community case management (iCCM)) for sick children 2-59 months old. Methods: Three complete teams of brigadistas (n = 12 brigadistas total) were selected from remote communities in the department of Matagalpa. Each respondent brigadista was interviewed privately regarding the frequency and duration (i...
November 2016: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28075314/sickness-absence-halved-in-trial-of-six-hour-day
#9
Erin Dean
Assistant nurses taking part in a trial of six-hour working days in Sweden reported higher rates of good health, calmness and alertness.
January 11, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28074819/percutaneous-tracheostomy
#10
REVIEW
Chitra Mehta, Yatin Mehta
Percutaneous dilatational tracheostomy (PDT) is a commonly performed procedure in critically sick patients. It can be safely performed bedside by intensivists.This has resulted in decline in the use of surgical tracheostomy in intensive care unit (ICU) except in few selected cases. Most common indication of tracheostomy in ICU is need for prolonged ventilation. About 10% of patients requiring at least 3 days of mechanical ventilator support get tracheostomised during ICU stay. The ideal timing of PDT remains undecided at present...
January 2017: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/28074475/what-makes-you-feel-sick-after-inflammation-predictors-of-acute-and-persisting-physical-sickness-symptoms-induced-by-experimental-endotoxemia
#11
Sven Benson, Harald Engler, Alexander Wegner, Laura Rebernik, Ingo Spreitzer, Manfred Schedlowski, Sigrid Elsenbruch
We aimed to identify statistical predictor variables of LPS-induced physical sickness symptoms during the acute and late inflammatory phases using multivariate regression analyses. Data from N=128 healthy volunteers who received i.v. LPS injection (0.4 or 0.8 ng/kg) or placebo were pooled for analyses. Physical sickness symptoms experienced during the acute (0-6h post-injection) and late (6-24h post-injection) phases were assessed with the validated General-Assessment-of-Side-Effects (GASE) questionnaire. LPS-treated subjects reported significantly more physical sickness symptoms...
January 11, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28073801/predictors-of-work-disability-after-start-of-anti-tnf-therapy-in-a-national-cohort-of-swedish-patients-with-rheumatoid-arthritis-does-early-anti-tnf-therapy-bring-patients-back-to-work
#12
T Olofsson, I F Petersson, J K Eriksson, M Englund, J A Nilsson, P Geborek, L T H Jacobsson, J Askling, M Neovius
OBJECTIVES: To examine predictors of work ability gain and loss after anti-tumour necrosis factor (TNF) start, respectively, in working-age patients with rheumatoid arthritis (RA) with a special focus on disease duration. METHODS: Patients with RA, aged 19-62 years, starting their first TNF inhibitor 2006-2009 with full work ability (0 sick leave/disability pension days during 3 months before bio-start; n=1048) or no work ability (90 days; n=753) were identified in the Swedish biologics register (Anti-Rheumatic Treatment In Sweden, ARTIS) and sick leave/disability pension days retrieved from the Social Insurance Agency...
January 10, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28073730/2014-anthrax-epidemic-in-koubia-prefecture-guinea-conakry
#13
M S Sow, M B Boushab, H Balde, A Camara, F B Sako, F A Traoré, M O S Diallo, M D Diallo, M Keita, A O Sylla, T M Tounkara, M Cissé
Anthrax disease is an anthropozoonosis caused by a Gram-positive bacterium, Bacillus anthracis. Our objective was to describe the epidemiological, clinical and therapeutic features of the 2014 epidemic in Koubia prefecture. This retrospective study examined all of the anthrax cases reported in Fafaya, Koubia Prefecture. In March and April 2014, there were 39 cases of human anthrax reported, for an incidence of 1.135%. The mean age was 20.9 (± 18.3) with a sex ratio of 2.54 (28/11) in favor of men. Seventy-six percent (23/39) were single...
November 1, 2016: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/28073181/participation-restrictions-in-ambulatory-als-patients-physical-and-psychological-factors
#14
Annerieke C van Groenestijn, Carin D Schröder, Esther T Kruitwagen-van Reenen, Leonard H van den Berg, Johanna M A Visser-Meily
INTRODUCTION: The aim of this study was to assess the prevalence of participation restrictions in ambulatory patients with amyotrophic lateral sclerosis (ALS) and to identify physical and psychological contributory factors. METHODS: In this cross-sectional study, self-reported participation restrictions of 72 ambulatory ALS patients were assessed using the social health status dimension (SIPSOC) of the Sickness Impact Profile (SIP-68). Associations between SIPSOC and physical functioning, psychological factors, and demographic factors were analyzed using hierarchical regression analyses...
January 10, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28072517/arthropod-innate-immune-systems-and-vector-borne-diseases
#15
Richard H G Baxter, Alicia Contet, Kathryn Krueger
Arthropods, especially ticks and mosquitoes, are the vectors for a number of parasitic and viral human diseases including malaria, sleeping sickness, Dengue and Zika. Yet arthropods show tremendous individual variation in their capacity to transmit disease. A key factor in this capacity is genetically encoded immune factors that counteract infection by the pathogen. Arthropod-specific pattern recognition receptors and protease cascades detect and respond to infection. Proteins such as antimicrobial peptides, thioester-containing proteins, and transglutaminases effect responses such as lysis, phagocytosis, melanization and agglutination...
January 10, 2017: Biochemistry
https://www.readbyqxmd.com/read/28069575/flawed-invisible-trial-underpins-us-morning-sickness-drug-researchers-say
#16
Owen Dyer
No abstract text is available yet for this article.
January 9, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28069461/is-acute-mountain-sickness-related-to-trait-anxiety-a-normobaric-chamber-study
#17
Martin Niedermeier, Robb Waanders, Verena Menz, Maria Wille, Martin Kopp, Martin Burtscher
INTRODUCTION: Some mountaineers are more prone to the occurrence of acute mountain sickness (AMS) than others. State anxiety during altitude exposure might be associated with AMS development. We hypothesized that trait anxiety might be higher in AMS cases compared to non-AMS cases. The aim of the present study was to study the relationship between AMS development and trait anxiety. METHODS: In an observational study design, AMS incidence during a 12-hour exposure to normobaric hypoxia (FiO2=12...
January 6, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28069020/work-outcome-in-persons-with-musculoskeletal-diseases-comparison-with-other-chronic-diseases-the-role-of-musculoskeletal-diseases-in-multimorbidity
#18
Antje van der Zee-Neuen, Polina Putrik, Sofia Ramiro, Andras Keszei, Rob de Bie, Astrid Chorus, Annelies Boonen
BACKGROUND: Chronic diseases and multimorbidity are increasingly common among persons in working age. This study explores the impact of type, number and combinations of chronic diseases with focus on the role of MSKD on (1) adverse work status (i.e. work disability (WD), economic unemployment (UE) or receiving a living allowance (LA)) and on (2) the occurrence of sick leave. METHODS: Subjects participating in a Dutch household survey, who were ≤65 years and could have paid work, provided data on socio-demographics and nine physician diagnosed chronic diseases...
January 10, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28068961/contradictory-individualized-self-blaming-a-cross-sectional-study-of-associations-between-expectations-to-managers-coworkers-one-self-and-risk-factors-for-musculoskeletal-disorders-among-construction-workers
#19
Jeppe Zielinski Nguyen Ajslev, Roger Persson, Lars Louis Andersen
BACKGROUND: Within work sociology, several studies have addressed construction workers' practices of masculinity, class, economy, safety risks and production. However, few studies have investigated room for agency in relation to bodily pain or musculoskeletal disorders and even fewer have made a quantitative approach. Accordingly, by means of a questionnaire, we examined the association between construction workers' room for agency and physical exertion, bodily and mental fatigue, and lower back pain...
January 10, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28068957/psychological-social-and-mechanical-work-exposures-and-disability-retirement-a-prospective-registry-study
#20
Jan S Emberland, Morten Birkeland Nielsen, Stein Knardahl
BACKGROUND: Relations between several occupational psychological and social factors and disability retirement remain largely unexplored. Knowledge of which specific aspects of the work environment that affect risk of disability is a prerequisite for the success of organizational interventions aiming to prevent premature work force exit. The objective of the present study was to determine contributions to registered disability retirement by a broad range of psychological and social work exposures while taking into account effects of mechanical exposure...
January 10, 2017: BMC Public Health
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